Purpose

This randomized phase II trial studies how well dabrafenib and trametinib work in treating patients with stage III-IV melanoma that cannot be removed by surgery and contains a B-Raf proto-oncogene, serine/threonine kinase (BRAF) mutation. Dabrafenib and trametinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Criteria


Inclusion Criteria:

- Patients must have histologically or cytologically confirmed stage IV or unresectable
stage III BRAF V600E or BRAF V600K mutant melanoma

- Patients must have BRAF V600E or BRAF V600K mutation identified by a Clinical
Laboratory Improvement Amendments (CLIA)-certified laboratory; acceptable analytic
techniques include but are not restricted to DNA sequencing, pyrosequencing,
polymerase chain reaction (PCR), melting point assays, and immunohistochemistry

- Contrast-enhanced computed tomography (CT) scans of the neck, chest, abdomen and
pelvis are required; a whole body positron emission tomography (PET)/CT scan with
diagnostic quality images and intravenous iodinated contrast may be used in lieu of a
contrast enhanced CT of the neck, chest, abdomen and pelvis; contrast may be omitted
if the treating investigator believes that exposure to contrast poses an excessive
risk to the patient; patients must have measurable disease per Response Evaluation
Criteria in Solid Tumors (RECIST) 1.1; all measurable lesions must be assessed within
28 days prior to registration; tests to assess non-measurable disease must be
performed within 42 days prior to registration; all disease must be assessed and
documented on the Baseline Tumor Assessment Form (RECIST 1.1)

- Patients must not have received a prior BRAF or mitogen-activated protein kinase
kinase (MEK) inhibitor

- Patients with a history of brain metastases are eligible if the patient is
asymptomatic with no residual neurological dysfunction and has not received
enzyme-reducing anti-epileptic drugs or corticosteroids for at least 7 days prior to
registration.

- Patients must not have received any anti-cancer drug within 28 days prior to
registration, and must not have received any nitrosoureas or mitomycin C within 42
days prior to registration

- Patients must not have received any major surgery or immunotherapy within 28 days
prior to registration

- Patients must not have any unresolved toxicity greater than National Cancer Institute
(NCI)-CTCAE version (v) 4.0 grade 1 from previous anti-cancer therapy except alopecia
within 7 days prior to registration

- Absolute neutrophil count (ANC) >= 1,200/ul (obtained within 28 days prior to
registration)

- Platelets >= 100,000/ul (obtained within 28 days prior to registration)

- Hemoglobin >= 9 g/dL (obtained within 28 days prior to registration)

- Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (or =< 2.5 x upper
limit of normal [ULN] with Gilbert's syndrome) (obtained within 28 days prior to
registration)

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 2.5 x IULN (or
< 5 x IULN for patients with known liver metastases) (obtained within 28 days prior to
registration)

- Serum albumin >= 2.5 g/dL (obtained within 28 days prior to registration)

- Serum creatinine =< 1.5 x mg/dL OR measured or calculated creatinine clearance >= 50
mL/min; creatinine measurements must be obtained within 28 days prior to registration

- Patients must have lactate dehydrogenase (LDH) obtained within 28 days prior to
registration in order to obtain baseline stratification information

- Patients must have a left ventricular ejection fraction (LVEF) >= institutional lower
limit of normal (ILLN) by echocardiogram (ECHO) or multi gated acquisition scan (MUGA)
within 28 days prior to registration

- Patients must have corrected QT (QTc) =< 480 msec by electrocardiogram (ECG)
(corrected using the Bazett's formula) within 28 days prior to registration

- Patients with known history or current evidence of retinal vein occlusion (RVO) or
central serous retinopathy (CSR) are not eligible:

- History of RVO or CSR, or predisposing factors to RVO or CSR (e.g. uncontrolled
glaucoma or ocular hypertension, uncontrolled systemic disease such as
hypertension, diabetes mellitus, or history of hyperviscosity or
hypercoagulability syndromes)

- Visible retinal pathology as assessed by ophthalmic exam that is considered a
risk factor for RVO or CSR such as:

- Evidence of new optic disc cupping

- Evidence of new visual field defects

- Intraocular pressure > 21 mmHg

- NOTE: ophthalmic exam is required for all patients; exam must be obtained within
28 days prior to registration

- Patients must be able to take oral medications; patients must not have any impairment
of gastrointestinal function or gastrointestinal disease that may significantly alter
the absorption of protocol treatment (e.g. ulcerative disease, uncontrolled nausea,
vomiting, diarrhea, malabsorption syndrome or small bowel resection)

- Patients receiving anticoagulation treatment are allowed to participate with
international normalized ratio (INR) established within the therapeutic range

- Patients must not have a history of pneumonitis or interstitial lung disease

- Patients must not have any grade II/III/IV cardiac disease as defined by the New York
Heart Association criteria (i.e., patients with cardiac disease resulting in marked
limitation of physical activity or resulting in inability to carry on any physical
activity without discomfort), unstable angina pectoris, myocardial infarction within 6
months, or serious uncontrolled cardiac arrhythmia; abnormal cardiac valve morphology
(>= grade 2) documented by echocardiogram (subjects with grade 1 abnormalities [i.e.,
mild regurgitation/stenosis]) can be entered on study; patients with a history of
atrial fibrillation must have atrial fibrillation controlled for at least 30 days
prior to registration

- Patients with known hepatitis B or hepatitis C are not eligible, regardless of
concomitant antiretroviral therapy or current viral load

- Patients with known human immunodeficiency virus (HIV) may be eligible providing they
meet the following additional criteria:

- Cluster of differentiation (CD)4 cells >= 500/uL

- Serum HIV viral load of < 25,000 IU/ml

- No current antiretroviral therapy

- Tests must be obtained within 28 days prior to registration; patients who
are HIV positive (+) and do not meet all of these criteria are not eligible
for this study (HIV/hepatitis testing are not required for patients without
known infection)

- Pre-study history and physical must be obtained with 28 days prior to registration

- Patients must have dermatology exam obtained within 28 days prior to registration to
obtain baseline measurement; exam to be performed by treating physician or designated
dermatologist

- Patients must have Zubrod performance status of 0, 1 or 2

- No other prior malignancy is allowed except for the following: adequately treated
basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
stage I or II cancer from which the patient is currently in complete remission, or any
other cancer from which the patient has been disease free for three years; exception:
patients with known history of colon cancer, cancer of the pancreas, or any cancer
known to harbor an activating RAS mutation are ineligible regardless of stage or time
since diagnosis

- Patients must not be pregnant or nursing; women/men of reproductive potential must
have agreed to use an effective contraceptive method; a woman is considered to be of
"reproductive potential" if she has had menses at any time in the preceding 12
consecutive months; in addition to routine contraceptive methods, "effective
contraception" also includes heterosexual celibacy and surgery intended to prevent
pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy,
bilateral oophorectomy or bilateral tubal ligation; however, if at any point a
previously celibate patient chooses to become heterosexually active during the time
period for use of contraceptive measures outlined in the protocol, he/she is
responsible for beginning contraceptive measures; hormonal contraception is not
allowed

- Patients must be offered the opportunity to participate in specimen banking

- Patients with cutaneous or superficial lesions that do not require imaging guidance
for biopsy must be willing to undergo biopsies for tissue submission and blood draws
for translational medicine

- Patients or their legally authorized representative must be informed of the
investigational nature of this study and must sign and give written informed consent
in accordance with institutional and federal guidelines

- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the
treating institution's identity is provided in order to ensure that the current
(within 365 days) date of institutional review board approval for this study has been
entered in the system

- STEP 2: RANDOMIZATION

- After completing one cycle of therapy, patients will be registered for randomization
between intermittent and continuous dosing, provided that they were eligible for the
initial step 1 registration and satisfy the following criteria

- Patients must not have unequivocal disease progression (by RECIST v1.1) during the
first cycle; patients must have disease assessed using the same method as baseline
within +/- 5 days of the day 56 scheduled assessment (between days 51-55 of cycle 1,
or days 1-5 of cycle 2); all disease must be assessed and documented on the follow-up
tumor assessment form (RECIST 1.1)

- Patients must be registered to step 2: randomization within +/- 5 days of starting
cycle 2; patients MUST NOT be registered prior to the day 56 disease assessment

Study Design

Phase
Phase 2
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm I (continuous dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-56. Courses repeat every 56 days in the absence of disease progression or unacceptable toxicity.
  • Drug: Dabrafenib
    Given PO
    Other names:
    • BRAF Inhibitor GSK2118436
    • GSK-2118436A
    • GSK2118436
  • Other: Laboratory Biomarker Analysis
    Correlative studies
  • Drug: Trametinib
    Given PO
    Other names:
    • GSK1120212
    • JTP-74057
    • MEK Inhibitor GSK1120212
    • Mekinist
Experimental
Arm II (intermittent dosing)
Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56. Courses repeat every 56 days in the absence of disease progression or unacceptable toxicity.
  • Drug: Dabrafenib
    Given PO
    Other names:
    • BRAF Inhibitor GSK2118436
    • GSK-2118436A
    • GSK2118436
  • Other: Laboratory Biomarker Analysis
    Correlative studies
  • Drug: Trametinib
    Given PO
    Other names:
    • GSK1120212
    • JTP-74057
    • MEK Inhibitor GSK1120212
    • Mekinist

Recruiting Locations

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
Contact:
Site Public Contact
205-934-0220
tmyrick@uab.edu

Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Women's Cancer Care
Anchorage, Alaska 99508
Contact:
Site Public Contact
protocols@swog.org

Anchorage Oncology Centre
Anchorage, Alaska 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Katmai Oncology Group
Anchorage, Alaska 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Providence Alaska Medical Center
Anchorage, Alaska 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719
Contact:
Site Public Contact
800-327-2873

The University of Arizona Medical Center-University Campus
Tucson, Arizona 85724
Contact:
Site Public Contact
520-626-9008

Yuma Cancer Center
Yuma, Arizona 85364
Contact:
Site Public Contact
928-336-3366

CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas 71913
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Fowler Family Center for Cancer Care
Jonesboro, Arkansas 72401
Contact:
Site Public Contact
870-936-7067
Dawn.Smith@BMHCC.org

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Contact:
Site Public Contact
501-686-8274

Veteran's Administration Medical Center
Little Rock, Arkansas 72205
Contact:
Site Public Contact
protocols@swog.org

Kaiser Permanente-Anaheim
Anaheim, California 92806
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Deer Valley Medical Center
Antioch, California 94531
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

PCR Oncology
Arroyo Grande, California 93420
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Kaiser Permanente-Baldwin Park
Baldwin Park, California 91706
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Bellflower
Bellflower, California 90706
Contact:
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800-398-3996
clinical.trials@kp.org

Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
Contact:
Site Public Contact
818-847-4793
Madonna.Johnson@providence.org

Epic Care-Dublin
Dublin, California 94568
Contact:
Site Public Contact
925-875-1677

Bay Area Breast Surgeons Inc
Emeryville, California 94608
Contact:
Site Public Contact
510-835-9900

Epic Care Partners in Cancer Care
Emeryville, California 94608
Contact:
Site Public Contact
510-629-6682

Kaiser Permanente-Fontana
Fontana, California 92335
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Fremont
Fremont, California 94538
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Fresno
Fresno, California 93720
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877-642-4691
Kpoct@kp.org

Kaiser Permanente - Harbor City
Harbor City, California 90710
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800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Irvine
Irvine, California 92618
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800-398-3996
clinical.trials@kp.org

Kaiser Permanente Los Angeles Medical Center
Los Angeles, California 90027
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800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Cadillac
Los Angeles, California 90034
Contact:
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800-398-3996
clinical.trials@kp.org

UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California 90095
Contact:
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888-798-0719

Contra Costa Regional Medical Center
Martinez, California 94553-3156
Contact:
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925-957-5400

Kaiser Permanente-Modesto
Modesto, California 95356
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877-642-4691
Kpoct@kp.org

Alta Bates Summit Medical Center - Summit Campus
Oakland, California 94609
Contact:
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510-204-1414

Bay Area Tumor Institute
Oakland, California 94609
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510-465-2242
lradke@bati.org

Kaiser Permanente Oakland-Broadway
Oakland, California 94611
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877-642-4691
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Kaiser Permanente-Oakland
Oakland, California 94611
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877-642-4691
Kpoct@kp.org

Kaiser Permanente - Panorama City
Panorama City, California 91402
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800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California 95670
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877-642-4691
Kpoct@kp.org

Eisenhower Medical Center
Rancho Mirage, California 92270
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760-834-3798

Kaiser Permanente-Redwood City
Redwood City, California 94063
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Richmond
Richmond, California 94801
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Riverside
Riverside, California 92505
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800-398-3996
clinical.trials@kp.org

Rohnert Park Cancer Center
Rohnert Park, California 94928
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Roseville
Roseville, California 95661
Contact:
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877-642-4691
Kpoct@kp.org

The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California 95678
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente Downtown Commons
Sacramento, California 95814
Contact:
Site Public Contact
877-642-4691

Kaiser Permanente-South Sacramento
Sacramento, California 95823
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877-642-4691
Kpoct@kp.org

South Sacramento Cancer Center
Sacramento, California 95823
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente - Sacramento
Sacramento, California 95825
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-San Diego Mission
San Diego, California 92108
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-San Diego Zion
San Diego, California 92120
Contact:
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800-398-3996
clinical.trials@kp.org

Kaiser Permanente-San Francisco
San Francisco, California 94115
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

UCSF Medical Center-Mount Zion
San Francisco, California 94115
Contact:
Site Public Contact
877-827-3222

Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente San Leandro
San Leandro, California 94577
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-San Marcos
San Marcos, California 92078
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-San Rafael
San Rafael, California 94903
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser San Rafael-Gallinas
San Rafael, California 94903
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
Contact:
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877-642-4691
Kpoct@kp.org

Kaiser Permanente Cancer Treatment Center
South San Francisco, California 94080
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-South San Francisco
South San Francisco, California 94080
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Stockton
Stockton, California 95210
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente Medical Center-Vacaville
Vacaville, California 95688
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Vallejo
Vallejo, California 94589
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Epic Care Cyberknife Center
Walnut Creek, California 94597
Contact:
Site Public Contact
510-465-8016
somega@bati.org

Kaiser Permanente-Woodland Hills
Woodland Hills, California 91367
Contact:
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800-398-3996
clinical.trials@kp.org

Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

University of Colorado Hospital
Aurora, Colorado 80045
Contact:
Site Public Contact
720-848-0650

Boulder Community Hospital
Boulder, Colorado 80301
Contact:
Site Public Contact
303-777-2663
jbloomfield@co-cancerresearch.org

Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado 80907
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Denver Health Medical Center
Denver, Colorado 80204
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Kaiser Permanente-Franklin
Denver, Colorado 80205
Contact:
Site Public Contact
303-764-5056
josh.b.gordon@nsmtp.kp.org

The Women's Imaging Center
Denver, Colorado 80209
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Porter Adventist Hospital
Denver, Colorado 80210
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Colorado Blood Cancer Institute
Denver, Colorado 80218
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado 80218
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Rocky Mountain Cancer Centers-Midtown
Denver, Colorado 80218
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

SCL Health Saint Joseph Hospital
Denver, Colorado 80218
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Rocky Mountain Cancer Centers-Rose
Denver, Colorado 80220
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Mercy Medical Center
Durango, Colorado 81301
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Southwest Oncology PC
Durango, Colorado 81301
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood, Colorado 80113
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Swedish Medical Center
Englewood, Colorado 80113
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Poudre Valley Hospital
Fort Collins, Colorado 80524
Contact:
Site Public Contact
970-297-6150

Mountain Blue Cancer Care Center
Golden, Colorado 80401
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

National Jewish Health-Western Hematology Oncology
Golden, Colorado 80401
Contact:
Site Public Contact
303-777-2663
glicht@co-cancerresearch.org

Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado 81501
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

North Colorado Medical Center
Greeley, Colorado 80631
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Good Samaritan Medical Center
Lafayette, Colorado 80026
Contact:
Site Public Contact
303-673-1622

Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
Contact:
Site Public Contact
303-764-5056
josh.b.gordon@nsmtp.kp.org

Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado 80228
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Saint Anthony Hospital
Lakewood, Colorado 80228
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Littleton Adventist Hospital
Littleton, Colorado 80122
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124
Contact:
Site Public Contact
303-764-5056
josh.b.gordon@nsmtp.kp.org

Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Longmont United Hospital
Longmont, Colorado 80501
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado 80501
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

McKee Medical Center
Loveland, Colorado 80539
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Parker Adventist Hospital
Parker, Colorado 80138
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Rocky Mountain Cancer Centers-Parker
Parker, Colorado 80138
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Rocky Mountain Cancer Centers - Pueblo
Pueblo, Colorado 81008
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado 80260
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Beebe Medical Center
Lewes, Delaware 19958
Contact:
Site Public Contact
302-645-3770
Dmiskin@Beebehealthcare.org

Delaware Clinical and Laboratory Physicians PA
Newark, Delaware 19713
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Helen F Graham Cancer Center
Newark, Delaware 19713
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Regional Hematology and Oncology PA
Newark, Delaware 19713
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Beebe Health Campus
Rehoboth Beach, Delaware 19971
Contact:
Site Public Contact
302-645-3100
Dmiskin@Beebehealthcare.org

Nanticoke Memorial Hospital
Seaford, Delaware 19973
Contact:
Site Public Contact
302-645-3100
Dmiskin@Beebehealthcare.org

Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware 19801
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Florida Hospital Cancer Institute Altamonte
Altamonte Springs, Florida 32701
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Mount Sinai Comprehensive Cancer Center at Aventura
Aventura, Florida 33180
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Holy Cross Hospital
Fort Lauderdale, Florida 33308
Contact:
Site Public Contact
954-267-7750

Florida Hospital Kissimmee
Kissimmee, Florida 34744
Contact:
Site Public Contact
407-303-5999

Mount Sinai Medical Center
Miami Beach, Florida 33140
Contact:
Site Public Contact
305-674-2625
info@msccop.com

Florida Hospital Orlando
Orlando, Florida 32803
Contact:
Site Public Contact
407-303-2090
FH.Cancer.Research@flhosp.org

Florida Urology Associates-Orlando
Orlando, Florida 32803
Contact:
Site Public Contact
407-897-3499

UF Cancer Center at Orlando Health
Orlando, Florida 32806
Contact:
Site Public Contact
321-841-7246
CancerClinicalTrials@orlandohealth.com

Florida Hospital East Orlando
Orlando, Florida 32822
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Florida Hospital Cancer Institute Winter Park
Winter Park, Florida 32792
Contact:
Site Public Contact
407-646-7777

Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
Contact:
Site Public Contact
404-778-1868

Memorial Health University Medical Center
Savannah, Georgia 31404
Contact:
Site Public Contact
912-350-7887
clayter1@memorialhealth.com

Summit Cancer Care-Memorial
Savannah, Georgia 31404
Contact:
Site Public Contact
912-350-7887
clayter1@memorialhealth.com

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
Contact:
Site Public Contact
protocols@swog.org

Summit Cancer Care-Candler
Savannah, Georgia 31405
Contact:
Site Public Contact
protocols@swog.org

Hawaii Oncology Inc-Pali Momi
'Aiea, Hawaii 96701
Contact:
Site Public Contact
808-487-7447

Pali Momi Medical Center
'Aiea, Hawaii 96701
Contact:
Site Public Contact
808-486-6000

The Cancer Center of Hawaii-Pali Momi
'Aiea, Hawaii 96701
Contact:
Site Public Contact
808-678-9000

Hawaii Cancer Care Inc-POB II
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-524-6115

Hawaii Oncology Inc-POB I
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-532-0315

Island Urology
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-536-2306
virginia@cc.hawaii.edu

Queen's Medical Center
Honolulu, Hawaii 96813
Contact:
Site Public Contact
protocols@swog.org

Straub Clinic and Hospital
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-522-4333

University of Hawaii Cancer Center
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-586-2979

Hawaii Cancer Care Inc-Liliha
Honolulu, Hawaii 96817
Contact:
Site Public Contact
808-536-4888

Hawaii Oncology Inc-Kuakini
Honolulu, Hawaii 96817
Contact:
Site Public Contact
808-531-8521

Kuakini Medical Center
Honolulu, Hawaii 96817
Contact:
Site Public Contact
808-547-9816

The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii 96817
Contact:
Site Public Contact
808-547-6881

Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819
Contact:
Site Public Contact
808-432-5195
shelley.a.clark@kp.org

Kapiolani Medical Center for Women and Children
Honolulu, Hawaii 96826
Contact:
Site Public Contact
808-983-6090

Tripler Army Medical Center
Honolulu, Hawaii 96859
Contact:
Site Public Contact
808-433-6336

Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue, Hawaii 96766
Contact:
Site Public Contact
808-535-7960

Saint Luke's Mountain States Tumor Institute
Boise, Idaho 83712
Contact:
Site Public Contact
protocols@swog.org

Kootenai Medical Center
Coeur d'Alene, Idaho 83814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho 83619
Contact:
Site Public Contact
protocols@swog.org

Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, Idaho 83642
Contact:
Site Public Contact
protocols@swog.org

Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, Idaho 83686
Contact:
Site Public Contact
protocols@swog.org

Kootenai Cancer Center
Post Falls, Idaho 83854
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kootenai Cancer Clinic
Sandpoint, Idaho 83864
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, Idaho 83301
Contact:
Site Public Contact
protocols@swog.org

Rush - Copley Medical Center
Aurora, Illinois 60504
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton, Illinois 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Memorial Hospital of Carbondale
Carbondale, Illinois 62902
Contact:
Site Public Contact
618-457-5200
clinical.research@sih.net

SIH Cancer Institute
Carterville, Illinois 62918
Contact:
Site Public Contact
618-985-3333
clinical.research@sih.net

Illinois CancerCare-Carthage
Carthage, Illinois 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Centralia Oncology Clinic
Centralia, Illinois 62801
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Carle on Vermilion
Danville, Illinois 61832
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Decatur Memorial Hospital
Decatur, Illinois 62526
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Carle Physician Group-Effingham
Effingham, Illinois 62401
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Crossroads Cancer Center
Effingham, Illinois 62401
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Illinois CancerCare-Eureka
Eureka, Illinois 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
Contact:
Site Public Contact
847-570-2109

Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
Contact:
Site Public Contact
309-344-2831

Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Contact:
Site Public Contact
630-315-1918
Claudine.Gamster@CadenceHealth.org

NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
Contact:
Site Public Contact
847-570-2109

NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
Contact:
Site Public Contact
847-570-2109

Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Macomb
Macomb, Illinois 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Loyola University Medical Center
Maywood, Illinois 60153
Contact:
Site Public Contact
708-226-4357

Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
Contact:
Site Public Contact
618-242-4600

Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Pekin
Pekin, Illinois 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Radiation Oncology at Pekin Cancer Treatment Center
Pekin, Illinois 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria, Illinois 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Methodist Medical Center of Illinois
Peoria, Illinois 61636
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Medical Center
Peoria, Illinois 61637
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru, Illinois 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Valley Radiation Oncology
Peru, Illinois 61354
Contact:
Site Public Contact
815-664-4141

Illinois CancerCare-Princeton
Princeton, Illinois 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois 61114
Contact:
Site Public Contact
779-696-9400
cancercare@swedishamerican.org

North Shore Medical Center
Skokie, Illinois 60076
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Southern Illinois University School of Medicine
Springfield, Illinois 62702
Contact:
Site Public Contact
217-545-7929

Springfield Clinic
Springfield, Illinois 62702
Contact:
Site Public Contact
800-444-7541

Memorial Medical Center
Springfield, Illinois 62781
Contact:
Site Public Contact
217-788-3528

Cancer Care Specialists of Illinois-Swansea
Swansea, Illinois 62226
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Southwest Illinois Health Services LLP
Swansea, Illinois 62226
Contact:
Site Public Contact
618-236-1000
lynns@thecancercenter.com

Carle Cancer Center
Urbana, Illinois 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

The Carle Foundation Hospital
Urbana, Illinois 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Contact:
Site Public Contact
630-315-1918
Claudine.Gamster@CadenceHealth.org

Rush-Copley Healthcare Center
Yorkville, Illinois 60560
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Deaconess Clinic Downtown
Evansville, Indiana 47713
Contact:
Site Public Contact
877-654-0311
Research@Deaconess.com

Memorial Regional Cancer Center Day Road
Mishawaka, Indiana 46545
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Chancellor Center for Oncology
Newburgh, Indiana 47630
Contact:
Site Public Contact
877-654-0311
Research@Deaconess.com

Reid Health
Richmond, Indiana 47374
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Memorial Hospital of South Bend
South Bend, Indiana 46601
Contact:
Site Public Contact
800-284-7370

Mary Greeley Medical Center
Ames, Iowa 50010
Contact:
Site Public Contact
515-956-4132

McFarland Clinic PC - Ames
Ames, Iowa 50010
Contact:
Site Public Contact
515-956-4132

McFarland Clinic PC-Boone
Boone, Iowa 50036
Contact:
Site Public Contact
515-956-4132

Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa 50325
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Alegent Health Mercy Hospital
Council Bluffs, Iowa 51503
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Greater Regional Medical Center
Creston, Iowa 50801
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Genesis Medical Center - East Campus
Davenport, Iowa 52803
Contact:
Site Public Contact
800-446-6088
werners@genesishealth.com

Iowa Methodist Medical Center
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-241-6727

Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-282-2921

Broadlawns Medical Center
Des Moines, Iowa 50314
Contact:
Site Public Contact
515-282-2200

Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa 50314
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Iowa Lutheran Hospital
Des Moines, Iowa 50316
Contact:
Site Public Contact
515-241-8704

McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-956-4132

Trinity Regional Medical Center
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-574-8302

McFarland Clinic PC-Jefferson
Jefferson, Iowa 50129
Contact:
Site Public Contact
515-956-4132

McFarland Clinic PC-Marshalltown
Marshalltown, Iowa 50158
Contact:
Site Public Contact
515-956-4132

Siouxland Regional Cancer Center
Sioux City, Iowa 51101
Contact:
Site Public Contact
712-252-0088

Methodist West Hospital
West Des Moines, Iowa 50266-7700
Contact:
Site Public Contact
515-343-1000

Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Cancer Center of Kansas - Chanute
Chanute, Kansas 66720
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Coffeyville Regional Medical Center
Coffeyville, Kansas 67337
Contact:
Site Public Contact
620-252-1606

Cancer Center of Kansas - Dodge City
Dodge City, Kansas 67801
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas - El Dorado
El Dorado, Kansas 67042
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas - Fort Scott
Fort Scott, Kansas 66701
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Hays Medical Center
Hays, Kansas 67601
Contact:
Site Public Contact
785-623-5774

Cancer Center of Kansas-Independence
Independence, Kansas 67301
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

University of Kansas Cancer Center-West
Kansas City, Kansas 66112
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

University of Kansas Cancer Center
Kansas City, Kansas 66160
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Cancer Center of Kansas-Kingman
Kingman, Kansas 67068
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Lawrence Memorial Hospital
Lawrence, Kansas 66044
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas-Liberal
Liberal, Kansas 67905
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas-Manhattan
Manhattan, Kansas 66502
Contact:
Site Public Contact
316-268-5784
Keisha.humphries@ascension.org

Cancer Center of Kansas - McPherson
McPherson, Kansas 67460
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas - Newton
Newton, Kansas 67114
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Olathe Medical Center
Olathe, Kansas 66061
Contact:
Site Public Contact
913-791-3500
Jeni.wakefield@olathehealth.org

Menorah Medical Center
Overland Park, Kansas 66209
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Cancer Center of Kansas - Parsons
Parsons, Kansas 67357
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Via Christi Hospital-Pittsburg
Pittsburg, Kansas 66762
Contact:
Site Public Contact
620-235-7900

Cancer Center of Kansas - Pratt
Pratt, Kansas 67124
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas - Salina
Salina, Kansas 67401
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Salina Regional Health Center
Salina, Kansas 67401
Contact:
Site Public Contact
785-452-7038
kkavoura@srhc.com

Saint Francis Hospital and Medical Center - Topeka
Topeka, Kansas 66606
Contact:
Site Public Contact
785-295-8000

Cancer Center of Kansas - Wellington
Wellington, Kansas 67152
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Associates In Womens Health
Wichita, Kansas 67208
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas 67208
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas - Wichita
Wichita, Kansas 67214
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Via Christi Regional Medical Center
Wichita, Kansas 67214
Contact:
Site Public Contact
800-362-0070
Keisha.humphries@ascension.org

Cancer Center of Kansas - Winfield
Winfield, Kansas 67156
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Flaget Memorial Hospital
Bardstown, Kentucky 40004
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Commonwealth Cancer Center-Corbin
Corbin, Kentucky 40701
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky 40504
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Saint Joseph Hospital East
Lexington, Kentucky 40509
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Saint Joseph London
London, Kentucky 40741
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Jewish Hospital
Louisville, Kentucky 40202
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky 40202
Contact:
Site Public Contact
502-562-3429

Saints Mary and Elizabeth Hospital
Louisville, Kentucky 40215
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Jewish Hospital Medical Center Northeast
Louisville, Kentucky 40245
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Jewish Hospital Medical Center South
Shepherdsville, Kentucky 40165
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Harold Alfond Center for Cancer Care
Augusta, Maine 04330
Contact:
Site Public Contact
207-626-4855

Eastern Maine Medical Center
Bangor, Maine 04401
Contact:
Site Public Contact
207-973-4274

Waldo County General Hospital
Belfast, Maine 04915
Contact:
Site Public Contact
207-338-2500

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford, Maine 04005
Contact:
Site Public Contact
LLemire@mmc.org

Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Contact:
Site Public Contact
800-987-3005

Penobscot Bay Medical Center
Rockport, Maine 04856
Contact:
Site Public Contact
207-921-8969

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, Maine 04073
Contact:
Site Public Contact
LLemire@mmc.org

Greater Baltimore Medical Center
Baltimore, Maryland 21204
Contact:
Site Public Contact
443-849-3706

Boston Medical Center
Boston, Massachusetts 02118
Contact:
Site Public Contact
617-638-8265

Hickman Cancer Center
Adrian, Michigan 49221
Contact:
Site Public Contact
517-265-0116

University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
Contact:
Site Public Contact
800-865-1125

Bronson Battle Creek
Battle Creek, Michigan 49017
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Mercy Health Saint Mary's
Grand Rapids, Michigan 49503
Contact:
Site Public Contact
protocols@swog.org

Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

West Michigan Cancer Center
Kalamazoo, Michigan 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Borgess Medical Center
Kalamazoo, Michigan 49048
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Toledo Clinic Cancer Centers-Monroe
Monroe, Michigan 48162
Contact:
Site Public Contact
800-444-3561

Mercy Health Mercy Campus
Muskegon, Michigan 49444
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Lakeland Hospital Niles
Niles, Michigan 49120
Contact:
Site Public Contact
protocols@swog.org

Huron Medical Center PC
Port Huron, Michigan 48060
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Spectrum Health Reed City Hospital
Reed City, Michigan 49677
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Munson Medical Center
Traverse City, Michigan 49684
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Metro Health Hospital
Wyoming, Michigan 49519
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Fairview Ridges Hospital
Burnsville, Minnesota 55337
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Mercy Hospital
Coon Rapids, Minnesota 55433
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview-Southdale Hospital
Edina, Minnesota 55435
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Unity Hospital
Fridley, Minnesota 55432
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Maple Grove Medical Center
Maple Grove, Minnesota 55369
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Hennepin County Medical Center
Minneapolis, Minnesota 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Health Partners Inc
Minneapolis, Minnesota 55454
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Monticello Cancer Center
Monticello, Minnesota 55362
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

New Ulm Medical Center
New Ulm, Minnesota 56073
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Regions Hospital
Saint Paul, Minnesota 55101
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

United Hospital
Saint Paul, Minnesota 55102
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Lakeview Hospital
Stillwater, Minnesota 55082
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Ridgeview Medical Center
Waconia, Minnesota 55387
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Rice Memorial Hospital
Willmar, Minnesota 56201
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Lakes Medical Center
Wyoming, Minnesota 55092
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Singing River Hospital
Pascagoula, Mississippi 39581
Contact:
Site Public Contact
228-809-5292

Parkland Health Center-Bonne Terre
Bonne Terre, Missouri 63628
Contact:
Site Public Contact
314-996-5569

Cox Cancer Center Branson
Branson, Missouri 65616
Contact:
Site Public Contact
417-269-4520

Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Southeast Cancer Center
Cape Girardeau, Missouri 63703
Contact:
Site Public Contact
573-651-5550

University of Missouri - Ellis Fischel
Columbia, Missouri 65212
Contact:
Site Public Contact
573-882-7440

Centerpoint Medical Center LLC
Independence, Missouri 64057
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

Capital Region Southwest Campus
Jefferson City, Missouri 65109
Contact:
Site Public Contact
573-632-4814
swooden@mail.crmc.org

Freeman Health System
Joplin, Missouri 64804
Contact:
Site Public Contact
417-347-4030
LJCrockett@freemanhealth.com

Mercy Hospital Joplin
Joplin, Missouri 64804
Contact:
Site Public Contact
417-556-3074
esmeralda.carrillo@mercy.net

Truman Medical Center
Kansas City, Missouri 64108
Contact:
Site Public Contact
816-404-4375

The University of Kansas Cancer Center-South
Kansas City, Missouri 64131
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Research Medical Center
Kansas City, Missouri 64132
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

The University of Kansas Cancer Center-North
Kansas City, Missouri 64154
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

The University of Kansas Cancer Center-Lee's Summit
Lee's Summit, Missouri 64064
Contact:
Site Public Contact
protocols@swog.org

Delbert Day Cancer Institute at PCRMC
Rolla, Missouri 65401
Contact:
Site Public Contact
573-458-7504
jrichards@research.pcrmc.com

Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
Contact:
Site Public Contact
573-458-7504
jrichards@research.pcrmc.com

Heartland Regional Medical Center
Saint Joseph, Missouri 64507
Contact:
Site Public Contact
816-271-7937
linda.schumacher@mymlc.com

Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
Contact:
Site Public Contact
314-353-1870

Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
Contact:
Site Public Contact
314-251-6770

Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Springfield
Springfield, Missouri 65804
Contact:
Site Public Contact
417-269-4520

CoxHealth South Hospital
Springfield, Missouri 65807
Contact:
Site Public Contact
417-269-4520

Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
Contact:
Site Public Contact
314-996-5569

Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri 63127
Contact:
Site Public Contact
314-996-5569

Community Hospital of Anaconda
Anaconda, Montana 59711
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Billings Clinic Cancer Center
Billings, Montana 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Saint Vincent Healthcare
Billings, Montana 59101
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Vincent Frontier Cancer Center
Billings, Montana 59102
Contact:
Site Public Contact
800-648-6274

Bozeman Deaconess Hospital
Bozeman, Montana 59715
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint James Community Hospital and Cancer Treatment Center
Butte, Montana 59701
Contact:
Site Public Contact
406-723-2621

Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Great Falls Clinic
Great Falls, Montana 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Peter's Community Hospital
Helena, Montana 59601
Contact:
Site Public Contact
protocols@swog.org

Kalispell Regional Medical Center
Kalispell, Montana 59901
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
Contact:
Site Public Contact
406-327-3118
amy.hanneman@providence.org

Community Medical Hospital
Missoula, Montana 59804
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

CHI Health Saint Francis
Grand Island, Nebraska 68803
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Heartland Hematology and Oncology
Kearney, Nebraska 68845
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

CHI Health Good Samaritan
Kearney, Nebraska 68847
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Saint Elizabeth Regional Medical Center
Lincoln, Nebraska 68510
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Alegent Health Immanuel Medical Center
Omaha, Nebraska 68122
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Hematology and Oncology Consultants PC
Omaha, Nebraska 68122
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska 68124
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Alegent Health Lakeside Hospital
Omaha, Nebraska 68130
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Creighton University Medical Center
Omaha, Nebraska 68131
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Midlands Community Hospital
Papillion, Nebraska 68046
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Carson Tahoe Regional Medical Center
Carson City, Nevada 89703
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Cancer and Blood Specialists-Henderson
Henderson, Nevada 89052
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada 89052
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Las Vegas Cancer Center-Henderson
Henderson, Nevada 89052
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Nevada Cancer Specialists-Saint Rose
Henderson, Nevada 89052
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

21st Century Oncology-Henderson
Henderson, Nevada 89074
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Desert West Surgery
Las Vegas, Nevada 89102
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Nevada Cancer Specialists?Oakey
Las Vegas, Nevada 89102
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

University Medical Center of Southern Nevada
Las Vegas, Nevada 89102
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Cancer and Blood Specialists-Shadow
Las Vegas, Nevada 89106
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

21st Century Oncology
Las Vegas, Nevada 89109
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, Nevada 89109
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, Nevada 89113
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada 89119
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Cancer Therapy and Integrative Medicine
Las Vegas, Nevada 89121
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

21st Century Oncology-Vegas Tenaya
Las Vegas, Nevada 89128
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Ann M Wierman MD LTD
Las Vegas, Nevada 89128
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Cancer and Blood Specialists-Tenaya
Las Vegas, Nevada 89128
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada 89128
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, Nevada 89128
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Nevada Cancer Specialists-Tenaya
Las Vegas, Nevada 89128
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada 89148-2405
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

21st Century Oncology-Fort Apache
Las Vegas, Nevada 89148
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Nevada Cancer Specialists-Fort Apache
Las Vegas, Nevada 89148
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, Nevada 89149
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada 89169
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

University Cancer Center
Las Vegas, Nevada 89169
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada 89048
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Renown Regional Medical Center
Reno, Nevada 89502
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Saint Mary's Regional Medical Center
Reno, Nevada 89503
Contact:
Site Public Contact
protocols@swog.org

Radiation Oncology Associates
Reno, Nevada 89509
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Hackensack University Medical Center
Hackensack, New Jersey 07601
Contact:
Site Public Contact
201-996-2879

Morristown Medical Center
Morristown, New Jersey 07960
Contact:
Site Public Contact
973-971-5900

Overlook Hospital
Summit, New Jersey 07902
Contact:
Site Public Contact
908-522-2043

University of Rochester
Rochester, New York 14642
Contact:
Site Public Contact
585-275-5830

Cancer Care of Western North Carolina
Asheville, North Carolina 28801
Contact:
Site Public Contact
800-506-2550
leslie.verner@msj.org

Mission Hospital Inc-Memorial Campus
Asheville, North Carolina 28801
Contact:
Site Public Contact
828-213-4150
leslie.verner@msj.org

Asheville Hematology-Oncology Associates
Asheville, North Carolina 28803
Contact:
Site Public Contact
828-681-2917
daniel.figueroa@ahss.org

Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328
Contact:
Site Public Contact
919-587-9077
ecooke@cancersmoc.com

Haywood Infusion Center
Clyde, North Carolina 28721
Contact:
Site Public Contact
protocols@swog.org

Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534
Contact:
Site Public Contact
919-587-9077
ecooke@cancersmoc.com

Wayne Memorial Hospital
Goldsboro, North Carolina 27534
Contact:
Site Public Contact
919-731-6687
ecooke@cancersmoc.com

Hendersonville Hematology and Oncology at Pardee
Hendersonville, North Carolina 28791
Contact:
James E. Radford
828-696-4716

Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
Contact:
Site Public Contact
828-696-4716
karen.morris@unchealth.unc.edu

Park Ridge Health
Hendersonville, North Carolina 28792
Contact:
Site Public Contact
828-681-2917
Daniel.Figueroa@ahss.org

Onslow Memorial Hospital
Jacksonville, North Carolina 28546
Contact:
Site Public Contact
910-353-0824
ecooke@cancersmoc.com

Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546
Contact:
Site Public Contact
910-353-0824
ecooke@cancersmoc.com

Vidant Oncology-Kinston
Kinston, North Carolina 28501
Contact:
Site Public Contact
252-559-2201
Carla.Zimmerman@vidanthealth.com

Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Strecker Cancer Center-Belpre
Belpre, Ohio 45714
Contact:
Site Public Contact
800-523-3977
sheree@columbusccop.org

Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Miami Valley Hospital South
Centerville, Ohio 45459
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Adena Regional Medical Center
Chillicothe, Ohio 45601
Contact:
Site Public Contact
877-779-7585
sheree@columbusccop.org

Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio 45236
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Bethesda North Hospital
Cincinnati, Ohio 45242
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

TriHealth Cancer Institute-Westside
Cincinnati, Ohio 45247
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

TriHealth Cancer Institute-Anderson
Cincinnati, Ohio 45255
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Riverside Methodist Hospital
Columbus, Ohio 43214
Contact:
Site Public Contact
614-566-4475
sheree@columbusccop.org

Grant Medical Center
Columbus, Ohio 43215
Contact:
Site Public Contact
614-566-4475
sheree@columbusccop.org

The Mark H Zangmeister Center
Columbus, Ohio 43219
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Mount Carmel Health Center West
Columbus, Ohio 43222
Contact:
Site Public Contact
614-234-5433
sheree@columbusccop.org

Doctors Hospital
Columbus, Ohio 43228
Contact:
Site Public Contact
614-566-3275
sheree@columbusccop.org

Good Samaritan Hospital - Dayton
Dayton, Ohio 45406
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Miami Valley Hospital
Dayton, Ohio 45409
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Dayton Physicians LLC-Samaritan North
Dayton, Ohio 45415
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Samaritan North Health Center
Dayton, Ohio 45415
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
Contact:
Site Public Contact
740-615-0227
sheree@columbusccop.org

Delaware Radiation Oncology
Delaware, Ohio 43015
Contact:
Site Public Contact
protocols@swog.org

Grady Memorial Hospital
Delaware, Ohio 43015
Contact:
Site Public Contact
740-615-2403
sheree@columbusccop.org

Armes Family Cancer Center
Findlay, Ohio 45840
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Blanchard Valley Hospital
Findlay, Ohio 45840
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Orion Cancer Care
Findlay, Ohio 45840
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Dayton Physicians LLC-Atrium
Franklin, Ohio 45005
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Dayton Physicians LLC-Wayne
Greenville, Ohio 45331
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Wayne Hospital
Greenville, Ohio 45331
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Greater Dayton Cancer Center
Kettering, Ohio 45409
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

First Dayton Cancer Care
Kettering, Ohio 45420
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Kettering Medical Center
Kettering, Ohio 45429
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Fairfield Medical Center
Lancaster, Ohio 43130
Contact:
Site Public Contact
740-687-8863
sheree@columbusccop.org

Marietta Memorial Hospital
Marietta, Ohio 45750
Contact:
Site Public Contact
800-523-3977
sheree@columbusccop.org

Licking Memorial Hospital
Newark, Ohio 43055
Contact:
Site Public Contact
740-348-4000
sheree@columbusccop.org

Newark Radiation Oncology
Newark, Ohio 43055
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio 43551
Contact:
Site Public Contact
419-479-5605
pshoup@toledoclinic.com

Southern Ohio Medical Center
Portsmouth, Ohio 45662
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Springfield Regional Cancer Center
Springfield, Ohio 45504
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Springfield Regional Medical Center
Springfield, Ohio 45505
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Mercy Saint Anne Hospital
Toledo, Ohio 43623
Contact:
Site Public Contact
419-407-1160

Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
Contact:
Site Public Contact
800-444-3561

Dayton Physicians LLC-Upper Valley
Troy, Ohio 45373
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Upper Valley Medical Center
Troy, Ohio 45373
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Saint Ann's Hospital
Westerville, Ohio 43081
Contact:
Site Public Contact
protocols@swog.org

Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701
Contact:
Site Public Contact
740-454-5232
sheree@columbusccop.org

Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
Contact:
Site Public Contact
877-231-4440

University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Integris Southwest Medical Center
Oklahoma City, Oklahoma 73109
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
Contact:
Site Public Contact
405-752-3402

Integris Cancer Institute of Oklahoma
Oklahoma City, Oklahoma 73142
Contact:
Site Public Contact
405-773-6613

Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
Contact:
Site Public Contact
918-505-3200

Saint Charles Health System
Bend, Oregon 97701
Contact:
Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org

Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Oncology and Hematology Care Southeast
Clackamas, Oregon 97015
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Bay Area Hospital
Coos Bay, Oregon 97420
Contact:
Site Public Contact
541-269-8392
cherie.cox@bayareahospital.org

Providence Newberg Medical Center
Newberg, Oregon 97132
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Portland Medical Center
Portland, Oregon 97213
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Portland, Oregon 97225
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Kaiser Permanente Northwest
Portland, Oregon 97227
Contact:
Site Public Contact
503-335-2400
information@kpchr.org

Saint Charles Health System-Redmond
Redmond, Oregon 97756
Contact:
Site Public Contact
541-706-2909

Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Geisinger Medical Center
Danville, Pennsylvania 17822
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania 18201
Contact:
Site Public Contact
570-459-2901
HemonCCTrials@geisinger.edu

Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
Contact:
Site Public Contact
570-374-8555
HemonCCTrials@geisinger.edu

Lewistown Hospital
Lewistown, Pennsylvania 17044
Contact:
Site Public Contact
717-242-7703
HemonCCTrials@geisinger.edu

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-647-8073

Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania 17901
Contact:
Site Public Contact
800-275-6401
HemonCCTrials@geisinger.edu

Community Medical Center
Scranton, Pennsylvania 18510
Contact:
Site Public Contact
570-703-4768
HemonCCTrials@geisinger.edu

Geisinger Medical Oncology-Selinsgrove
Selinsgrove, Pennsylvania 17870
Contact:
Site Public Contact
570-374-8555
HemonCCTrials@geisinger.edu

Geisinger Medical Group
State College, Pennsylvania 16801
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Reading Hospital
West Reading, Pennsylvania 19611
Contact:
Site Public Contact
610-988-9323

Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

UPMC Susquehanna
Williamsport, Pennsylvania 17701
Contact:
Site Public Contact
800-598-4282

AnMed Health Cancer Center
Anderson, South Carolina 29621
Contact:
Site Public Contact
864-512-4651
rhonda.ballew@anmedhealth.org

Gibbs Cancer Center-Gaffney
Gaffney, South Carolina 29341
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Saint Francis Hospital
Greenville, South Carolina 29601
Contact:
Site Public Contact
864-603-6213
meissa_beckman@bshsi.org

Saint Francis Cancer Center
Greenville, South Carolina 29607
Contact:
Site Public Contact
864-603-6213
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Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
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864-560-6104
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Spartanburg Medical Center
Spartanburg, South Carolina 29303
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MGC Hematology Oncology-Union
Union, South Carolina 29379
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Rapid City Regional Hospital
Rapid City, South Dakota 57701
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605-716-3982
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Wellmont Bristol Regional Medical Center
Bristol, Tennessee 37620
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Memorial Hospital
Chattanooga, Tennessee 37404
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Pulmonary Medicine Center of Chattanooga-Hixson
Hixson, Tennessee 37343
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Wellmont Medical Associates Oncology and Hematology-Johnson City
Johnson City, Tennessee 37604
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Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee 37660
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Wellmont Medical Associates Oncology and Hematology-Kingsport
Kingsport, Tennessee 37660
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Memorial GYN Plus
Ooltewah, Tennessee 37363
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Saint Joseph Regional Cancer Center
Bryan, Texas 77802
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Farmington Health Center
Farmington, Utah 84025
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888-424-2100
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Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
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South Jordan Health Center
South Jordan, Utah 84009
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Wellmont Medical Associates-Bristol
Bristol, Virginia 24201
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Southwest VA Regional Cancer Center
Norton, Virginia 24273
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Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
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360-412-8958
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PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
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Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington 98310
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Harrison Medical Center
Bremerton, Washington 98310
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Highline Medical Center-Main Campus
Burien, Washington 98166
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Providence Regional Cancer System-Centralia
Centralia, Washington 98531
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Swedish Medical Center-Edmonds
Edmonds, Washington 98026
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Saint Elizabeth Hospital
Enumclaw, Washington 98022
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Providence Regional Cancer Partnership
Everett, Washington 98201
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Saint Francis Hospital
Federal Way, Washington 98003
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Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
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Lacey, Washington 98503
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Saint Clare Hospital
Lakewood, Washington 98499
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Longview, Washington 98632
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Poulsbo, Washington 98370
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Pacific Gynecology Specialists
Seattle, Washington 98104
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Seattle, Washington 98107
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Seattle, Washington 98112
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Swedish Medical Center-First Hill
Seattle, Washington 98122-4307
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PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
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Providence Regional Cancer System-Shelton
Shelton, Washington 98584
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Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington 98405
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Northwest Medical Specialties PLLC
Tacoma, Washington 98405
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PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
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Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
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509-897-5993
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Providence Regional Cancer System-Yelm
Yelm, Washington 98597
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Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
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414-302-2304
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Aurora Health Center-Fond du Lac
Fond Du Lac, Wisconsin 54937
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414-302-2304
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Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
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414-302-2304
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Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
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Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
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UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin 53038
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920-699-3500
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Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
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Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
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608-775-2385
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University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
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800-622-8922

Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
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414-302-2304
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Vince Lombardi Cancer Clinic-Marinette
Marinette, Wisconsin 54143
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Thomas J. Saphner
414-649-5717

Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
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414-302-2304
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Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
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888-823-5923
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Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin 53226
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414-805-4380

Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
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414-302-2304
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ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
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888-823-5923
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Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
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952-993-1517
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ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
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262-928-7878

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
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414-302-2304
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Aurora Cancer Care-Racine
Racine, Wisconsin 53406
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414-302-2304
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Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
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414-302-2304
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Aurora Medical Center in Summit
Summit, Wisconsin 53066
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414-302-2304
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Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
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414-302-2304
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ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
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262-928-7632

UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
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262-928-5539
Chanda.miller@phci.org

Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
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414-302-2304
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Aurora West Allis Medical Center
West Allis, Wisconsin 53227
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414-302-2304
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Cheyenne Regional Medical Center-West
Cheyenne, Wyoming 82001
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303-777-2663
ccrp@co-cancerresearch.org

Billings Clinic-Cody
Cody, Wyoming 82414
Contact:
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800-996-2663
research@billingsclinic.org

Welch Cancer Center
Sheridan, Wyoming 82801
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

More Details

NCT ID
NCT02196181
Status
Recruiting
Sponsor
National Cancer Institute (NCI)

Detailed Description

PRIMARY OBJECTIVES:

I. To compare progression-free survival with intermittent dosing and continuous dosing of dabrafenib and trametinib among patients with metastatic BRAF V600E/K mutant melanoma.

SECONDARY OBJECTIVES:

I. To estimate the frequency and severity of toxicities of the two dosing schedules.

II. To compare the frequency and severity of fever >= grade 1 per Common Terminology Criteria for Adverse Events (CTCAE) 4.0 of the two dosing schedules.

III. To compare the response rate (complete and partial response, confirmed and unconfirmed), overall survival, and survival after progression between the two dosing schedules on step 2.

TERTIARY OBJECTIVES:

I. To evaluate whether acquired molecular events leading to reactivation of the MAPK pathway are more common among patients on the continuous dosing arm than on the intermittent dosing arm using circulating tumor deoxyribonucleic acid (DNA) (ctDNA).

II. To assess the prognostic association between baseline biomarkers and early molecular events with progression free survival (PFS).

III. To explore the potential interaction between treatment arm and baseline biomarkers/early molecular events with PFS.

IV. To bank tissue and whole blood in anticipation of future studies to evaluate molecular events associated with clinical benefit and disease progression in patients treated with continuous versus intermittent dabrafenib and trametinib.

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM I (CONTINUOUS DOSING): Patients receive dabrafenib orally (PO) twice daily (BID) and trametinib PO once daily (QD) on days 1-56. Courses repeat every 56 days in the absence of disease progression or unacceptable toxicity.

ARM II (INTERMITTENT DOSING): Patients receive dabrafenib PO BID and trametinib PO QD on days 1-7 and 29-56. Courses repeat every 56 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up every 6 months for 3 years and then yearly for 2 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.