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Transformative Research in Diabetic Nephropathy
University of Pennsylvania
Diabetic Nephropathies
Diabetic Glomerulosclerosis
This is a prospective, observational, cohort study of patients with a clinical diagnosis
of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to
collect, process, and study kidney tissue and to harvest blood, urine and genetic
materials to elucidate molecular pathways and... expand
This is a prospective, observational, cohort study of patients with a clinical diagnosis of diabetes who are undergoing clinically indicated kidney biopsy. The intent is to collect, process, and study kidney tissue and to harvest blood, urine and genetic materials to elucidate molecular pathways and link them to biomarkers that characterize those patients have a rapid decline in kidney function (> 5 mL/min/1.73m2/year) from those with lesser degrees of kidney function change over the period of observation. High through-put genomic analysis associated with genetic and biomarker testing will serve to identify key potential therapeutic targets for DKD by comparing patients with rapid and slow progression patterns. Each participating clinical site will search for, consent, harvest the biopsy sample, and enroll the participants as required for the TRIDENT protocol. Type: Observational Start Date: Dec 2016 |
HEALEY ALS Platform Trial - Regimen D Pridopidine
Merit E. Cudkowicz, MD
Amyotrophic Lateral Sclerosis
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial
evaluating the safety and efficacy of investigational products for the treatment of ALS.
Regimen D will evaluate the safety and efficacy of a single study drug, pridopidine, in
participants with ALS. expand
The HEALEY ALS Platform Trial is a perpetual multi-center, multi-regimen clinical trial evaluating the safety and efficacy of investigational products for the treatment of ALS. Regimen D will evaluate the safety and efficacy of a single study drug, pridopidine, in participants with ALS. Type: Interventional Start Date: Dec 2020 |
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