Regional Radiotherapy in Biomarker Low-Risk Node Positive and T3N0 Breast Cancer

Purpose

The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.

Condition

  • Breast Cancer

Eligibility

Eligible Ages
Over 35 Years
Eligible Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patients must be women with newly diagnosed histologically proven invasive carcinoma of the breast with no evidence of metastases, staged as per site standard of care. - Patients must have been treated by BCS or mastectomy with clear margins of excision. Post-mastectomy positive margins for invasive disease and/or DCIS is not allowed. Multifocal disease (i.e. the presence of two or more foci or breast cancer within the same breast quadrant) and multicentric disease (i.e. the presence of two or more foci of breast cancer in different quadrants of the same breast) are allowed. - Patients with T3N0 disease are eligible. - Patients with disease limited to nodal micrometastases are eligible - Patients with nodal macrometastases (>2mm) treated by axillary dissection must have 1-3 positive axillary nodes (macrometastases, > 2 mm). - Patients treated by mastectomy and SLNB alone must have only 1-2 positive axillary nodes (macrometastases, > 2 mm). - Patients must be ER ≥ 1% and HER2 negative on local testing - Patients must have an Oncotype DX recurrence score ≤25 obtained from testing of breast tumour tissue from a core biopsy or from the surgical specimen. - Patient must consent to provision of, and investigator(s) must agree to submit to the CCTG Central Tumour Bank, a representative formalin fixed paraffin block of tumour tissue in order that the specific correlative marker assays described in the protocol may be conducted - Patient must consent to provision of samples of blood in order that the specific correlative marker assays described in the protocol may be conducted. - Patients must have had endocrine therapy initiated or planned for ≥ 5 years. Premenopausal women will receive ovarian ablation plus aromatase inhibitor therapy or tamoxifen if adjuvant chemotherapy was not administered. For all patients, endocrine therapy can be given concurrently or following RT. - Patients may or may not have had adjuvant chemotherapy. - RT must commence within 16 weeks of definitive surgery if the patient is not treated with chemotherapy. If adjuvant chemotherapy is given, RT must begin within 12 weeks after the last dose. (Note: adjuvant chemotherapy may be ongoing at the time of randomization). Definitive surgery is defined as the last breast cancer-related surgery. - Patient's ECOG performance status must be 0, 1 or 2. - Patient's age must be ≥ 35 years. - For the first 736 eligible English or French-speaking subjects who have agreed to optional questionnaire completion: Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life, health utilities and lost productivity questionnaires in either English or French (note: enrollment completed 2022Aug02) - Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements - Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up. - In accordance with CCTG policy, protocol treatment is to begin within 6 weeks of patient randomization. - Women of childbearing potential must have agreed to use an effective contraceptive method. A woman is considered to be of "childbearing potential" if she has had menses at any time in the preceding 12 consecutive months.

Exclusion Criteria

  • Patients with nodal disease limited to isolated tumour cells (pN0i+ < 0.2 mm). - Patients with pT3N1 and pT4 disease (Note: patients with T3N0 are eligible). - Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy. (Patients with synchronous or previous ipsilateral LCIS are eligible.) - Synchronous or previous contralateral invasive breast cancer. (Patients with contralateral DCIS are eligible unless previously treated with radiation.) - History of non-breast malignancies except adequately treated non-melanoma skin cancers, in situ cancers treated by local excision or other cancers curatively treated with no evidence of disease for ≥ 5 years. - Patients who are pregnant. - Patients that have had prior ipsilateral chestwall/thoracic radiation. - Patients treated with chemo or endocrine therapy administered in the neoadjuvant setting for breast cancer. Endocrine therapy exposure 12 weeks or less prior to surgery is permitted. - Patients with serious non-malignant disease (e.g. cardiovascular, scleroderma etc.) which would preclude RT. - Patients with any serious active or co-morbid medical conditions, laboratory abnormality, psychiatric illness, active or uncontrolled infections, or serious illnesses or medical conditions that would prevent the patient from participating or to be managed according to the protocol (according to investigator's decision).

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
No Regional Radiotherapy 		A. Whole Breast Irradiation (WBI) following BCS or; B. No Radiotherapy (RT) following mastectomy
  • Radiation: Radiation
    Radiotherapy given
  • Other: No Radiation
    No radiotherapy given
Active Comparator
Regional Radiotherapy 		A. WBI plus RT to the regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following BCS or; B. RT to the chestwall and regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following mastectomy
  • Radiation: Radiation
    Radiotherapy given
  • Other: No Radiation
    No radiotherapy given

Recruiting Locations

Fairbanks Memorial Hospital
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University of Arizona Cancer Center-Orange Grove Campus
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University of Arizona Cancer Center-North Campus
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Kaiser Permanente-Anaheim
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City of Hope Corona
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City of Hope Comprehensive Cancer Center
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Desert Regional Medical Center
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Saint Anthony's Hospital Cancer Care Center
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Saint Joseph's Hospital/Children's Hospital-Tampa
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Moffitt Cancer Center
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Cleveland Clinic-Weston
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Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
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Kootenai Health - Coeur d'Alene
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Northwestern University
Chicago 4887398, Illinois 4896861 60611
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Rush University Medical Center
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Swedish Covenant Hospital
Chicago 4887398, Illinois 4896861 60625
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University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
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Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
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Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
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Northwestern Medicine Cancer Center Kishwaukee
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Crossroads Cancer Center
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NorthShore University HealthSystem-Evanston Hospital
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Ingalls Memorial Hospital
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Northwestern Medicine Lake Forest Hospital
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Loyola University Medical Center
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UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861 60451
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University of Chicago Medicine-Orland Park
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Advocate Lutheran General Hospital
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OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861 61637
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UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861 61114
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Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
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Carle Cancer Center
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Community Cancer Center East
Indianapolis 4259418, Indiana 4921868 46219
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Community Cancer Center South
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Community Cancer Center North
Indianapolis 4259418, Indiana 4921868 46256
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IU Health Ball Memorial Hospital
Muncie 4924006, Indiana 4921868 47303
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Saint Luke's Hospital
Cedar Rapids 4850751, Iowa 4862182 52402
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Greater Regional Medical Center
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Iowa Methodist Medical Center
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University of Kansas Cancer Center
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Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
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Saint Elizabeth Healthcare Edgewood
Edgewood 4290873, Kentucky 6254925 41017
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Saint Elizabeth Healthcare Fort Thomas
Fort Thomas 4292071, Kentucky 6254925 41075
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Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925 40504
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The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925 40202
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UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925 40245
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MaineHealth Coastal Cancer Treatment Center
Bath 4957570, Maine 4971068 04530
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Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
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MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
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MaineHealth Cancer Care Center of York County
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Scarborough 4977882, Maine 4971068 04074
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Luminis Health Anne Arundel Medical Center
Annapolis 4347242, Maryland 4361885 21401
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443-481-1320
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University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
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Greater Baltimore Medical Center
Baltimore 4347778, Maryland 4361885 21204
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Saint Agnes Hospital
Baltimore 4347778, Maryland 4361885 21229
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410-368-2910

MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore 4347778, Maryland 4361885 21237
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MedStar Good Samaritan Hospital
Baltimore 4347778, Maryland 4361885 21239
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Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885 21287
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Suburban Hospital
Bethesda 4348599, Maryland 4361885 20814
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Easton 4353962, Maryland 4361885 21601
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410-822-1000
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UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885 21061
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UM Saint Joseph Medical Center
Towson 4371582, Maryland 4361885 21204
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Lowell General Hospital
Lowell 4942618, Massachusetts 6254926 01854
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978-788-7084
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Baystate Medical Center
Springfield 4951788, Massachusetts 6254926 01199
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413-794-3565
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University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
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800-865-1125
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McLaren Cancer Institute-Bay City
Bay City 4985180, Michigan 5001836 48706
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313-576-9790
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McLaren Cancer Institute-Clarkston
Clarkston 4988997, Michigan 5001836 48346
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Corewell Health Dearborn Hospital
Dearborn 4990510, Michigan 5001836 48124
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248-551-7695

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Farmington Hills 4992523, Michigan 5001836 48336
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Flint 4992982, Michigan 5001836 48532
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Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
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616-391-1230
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Grand Rapids 4994358, Michigan 5001836 49503
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616-391-1230
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West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
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Karmanos Cancer Institute at McLaren Greater Lansing
Lansing 4998830, Michigan 5001836 48910
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Mount Clemens 5002656, Michigan 5001836 48043
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Mount Pleasant 5002714, Michigan 5001836 48858
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ctoadmin@karmanos.org

Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836 49444
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Henry Ford Health Providence Novi Hospital
Novi 5004062, Michigan 5001836 48374
Contact:
Site Public Contact
248-849-5332
kfife3@hfhs.org

McLaren Cancer Institute-Northern Michigan
Petoskey 5005484, Michigan 5001836 49770
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

McLaren-Port Huron
Port Huron 5006233, Michigan 5001836 48060
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Henry Ford Health Providence Southfield Hospital
Southfield 5010636, Michigan 5001836 48075
Contact:
Site Public Contact
248-849-5332
kfife3@hfhs.org

Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695

University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Contact:
Site Public Contact
218-333-5000
OncologyClinicalTrialsFargo@sanfordhealth.org

Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia 4381982, Missouri 4398678 65212
Contact:
Site Public Contact
573-882-7440

University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Hi-Line Sletten Cancer Center
Havre 5656497, Montana 5667009 59501
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Community Medical Center
Missoula 5666639, Montana 5667009 59804
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Alegent Health Bergan Mercy Medical Center
Omaha 5074472, Nebraska 5073708 68124
Contact:
Site Public Contact
720-874-1881
ResearchInstituteInquiries@CommonSpirit.org

Radiation Oncology Centers of Nevada Central
Las Vegas 5506956, Nevada 5509151 89106
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Radiation Oncology Centers of Nevada Southeast
Las Vegas 5506956, Nevada 5509151 89119
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

New Hampshire Oncology Hematology PA-Concord
Concord 5084868, New Hampshire 5090174 03301
Contact:
Site Public Contact
603-224-2556

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@dartmouth.edu

Solinsky Center for Cancer Care
Manchester 5089178, New Hampshire 5090174 03103
Contact:
Site Public Contact
800-339-6484

Memorial Sloan Kettering Basking Ridge
Basking Ridge 5095409, New Jersey 5101760 07920
Contact:
Site Public Contact
212-639-7592

Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
Contact:
Site Public Contact
212-639-7592

Memorial Sloan Kettering Bergen
Montvale 5101361, New Jersey 5101760 07645
Contact:
Site Public Contact
212-639-7592

Saint Peter's University Hospital
New Brunswick 5101717, New Jersey 5101760 08901
Contact:
Site Public Contact
732-745-8600
kcovert@saintpetersuh.com

University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Contact:
Site Public Contact
505-925-0348
HSC-ClinicalTrialInfo@salud.unm.edu

Lovelace Radiation Oncology
Albuquerque 5454711, New Mexico 5481136 87109
Contact:
Site Public Contact
505-272-0530
AYost@nmcca.org

Memorial Medical Center-Las Cruces
Las Cruces 5475352, New Mexico 5481136 88011
Contact:
Site Public Contact
575-556-6545
Deborah.Brown@LPNT.net

Maimonides Medical Center
Brooklyn 5110302, New York 5128638 11219
Contact:
Site Public Contact
718-765-2500

Sands Cancer Center
Canandaigua 5111405, New York 5128638 14424
Contact:
Site Public Contact
585-396-6161

Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
Contact:
Site Public Contact
212-639-7592

Mary Imogene Bassett Hospital
Cooperstown 5113664, New York 5128638 13326
Contact:
Site Public Contact
877-547-1750
CancerClinicalTrials@bassett.org

Noyes Memorial Hospital/Myers Cancer Center
Dansville 5114492, New York 5128638 14437
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592

NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638 11501
Contact:
Site Public Contact
212-263-4432
cancertrials@nyulangone.org

Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638 10016
Contact:
Site Public Contact
CancerTrials@nyulangone.org

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
Contact:
Site Public Contact
212-342-5162
cancerclinicaltrials@cumc.columbia.edu

Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592

Nyack Hospital
Nyack 5129433, New York 5128638 10960
Contact:
Site Public Contact
845-348-8507

Wilmot Cancer Institute Radiation Oncology at Greece
Rochester 5134086, New York 5128638 14606
Contact:
Site Public Contact
585-758-7877

Highland Hospital
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113

Rochester General Hospital
Rochester 5134086, New York 5128638 14621
Contact:
Site Public Contact
585-922-3536
tia.derosa@rochestergeneral.org

Pluta Cancer Center
Rochester 5134086, New York 5128638 14623
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215

State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476

Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Memorial Sloan Kettering Nassau
Uniondale 5141927, New York 5128638 11553
Contact:
Site Public Contact
212-639-7592

Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

Mission Hospital
Asheville 4453066, North Carolina 4482348 28801
Contact:
Site Public Contact
828-213-7055
NCDV.ResearchRegulatory@HCAHealthcare.com

UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Contact:
Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu

Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853

Margaret R Pardee Memorial Hospital
Hendersonville 4470592, North Carolina 4482348 28791
Contact:
Site Public Contact
828-696-4716
pardeecancerresearch@unchealth.unc.edu

Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Altru Cancer Center
Grand Forks 5059429, North Dakota 5690763 58201
Contact:
Site Public Contact
701-780-6520

Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

UH Seidman Cancer Center at UH Avon Health Center
Avon 5146277, Ohio 5165418 44011
Contact:
Site Public Contact
800-641-2422

UHHS-Chagrin Highlands Medical Center
Beachwood 5146711, Ohio 5165418 44122
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Cleveland Clinic Mercy Hospital
Canton 5149222, Ohio 5165418 44708
Contact:
Site Public Contact
888-293-4673

Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Contact:
Site Public Contact
330-363-7274
ClinicalReserachDept@aultman.com

Geauga Hospital
Chardon 5149818, Ohio 5165418 44024
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418 44109
Contact:
Site Public Contact
216-778-7559
ababal@metrohealth.org

Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

The Mark H Zangmeister Center
Columbus 4509177, Ohio 5165418 43219
Contact:
Site Public Contact
614-488-2745
Jeffh@columbusccop.org

Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Mount Carmel Grove City Hospital
Grove City 4513409, Ohio 5165418 43123
Contact:
Site Public Contact
614-488-2745
Jeffh@columbusccop.org

OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor 5162645, Ohio 5165418 44060
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

UH Seidman Cancer Center at Southwest General Hospital
Middleburg Heights 5162851, Ohio 5165418 44130
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

University Hospitals Parma Medical Center
Parma 5166177, Ohio 5165418 44129
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Mercy Health - Perrysburg Hospital
Perrysburg 5166516, Ohio 5165418 43551
Contact:
Site Public Contact
614-488-2745
Jeffh@columbusccop.org

University Hospitals Portage Medical Center
Ravenna 5167737, Ohio 5165418 44266
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

UH Seidman Cancer Center at Firelands Regional Medical Center
Sandusky 5170691, Ohio 5165418 44870
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
Contact:
Site Public Contact
419-824-1842
PCIOncResearch@promedica.org

University Hospitals Sharon Health Center
Wadsworth 5175496, Ohio 5165418 44281
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Saint Ann's Hospital
Westerville 5176472, Ohio 5165418 43081
Contact:
Site Public Contact
614-488-2745
Jeffh@columbusccop.org

UH Seidman Cancer Center at Saint John Medical Center
Westlake 5176517, Ohio 5165418 44145
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

UHHS-Westlake Medical Center
Westlake 5176517, Ohio 5165418 44145
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
Contact:
Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org

Bryn Mawr Hospital
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Carlisle Regional Cancer Center
Carlisle 5183234, Pennsylvania 6254927 17015
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Chambersburg Hospital
Chambersburg 4557109, Pennsylvania 6254927 17201
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Ephrata Cancer Center
Ephrata 5188815, Pennsylvania 6254927 17522
Contact:
Site Public Contact
717-721-4840

UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927 16505
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Saint Vincent Hospital
Erie 5188843, Pennsylvania 6254927 16544
Contact:
Site Public Contact
814-452-5000

UPMC Cancer Center at UPMC Horizon
Farrell 5189377, Pennsylvania 6254927 16121
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Adams Cancer Center
Gettysburg 4558183, Pennsylvania 6254927 17325
Contact:
Site Public Contact
877-441-7957

UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg 5192029, Pennsylvania 6254927 15601
Contact:
Site Public Contact
724-838-1900

UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg 5192726, Pennsylvania 6254927 17109
Contact:
Site Public Contact
717-724-6765
klitchfield@PINNACLEHEALTH.org

Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Contact:
Site Public Contact
717-531-3779
CTO@hmc.psu.edu

IRMC Cancer Center
Indiana 5194868, Pennsylvania 6254927 15701
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown 5195561, Pennsylvania 6254927 15901
Contact:
Site Public Contact
814-534-4724

Lancaster General Ann B Barshinger Cancer Institute
Lancaster 5197079, Pennsylvania 6254927 17601
Contact:
Site Public Contact
717-544-0511
nctn@pennmedicine.upenn.edu

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Riddle Memorial Hospital
Media 4559575, Pennsylvania 6254927 19063
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-858-7746

UPMC Cancer Center - Monroeville
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Paoli Memorial Hospital
Paoli 5205037, Pennsylvania 6254927 19301
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Jefferson Torresdale Hospital
Philadelphia 4560349, Pennsylvania 6254927 19114
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000

UPMC-Magee Womens Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15213
Contact:
Site Public Contact
412-647-2811

UPMC-Saint Margaret
Pittsburgh 5206379, Pennsylvania 6254927 15215
Contact:
Site Public Contact
412-784-4900

West Penn Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15224
Contact:
Site Public Contact
412-578-5000

UPMC-Shadyside Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-621-2334

UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454

UPMC-Saint Clair Hospital Cancer Center
Pittsburgh 5206379, Pennsylvania 6254927 15243
Contact:
Site Public Contact
412-502-3920

UPMC Washington Hospital Radiation Oncology
Washington 5218069, Pennsylvania 6254927 15301
Contact:
Site Public Contact
724-223-3788
cancer@washingtonhospital.org

Reading Hospital
West Reading 5218867, Pennsylvania 6254927 19611
Contact:
Site Public Contact
610-988-9323

Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
Contact:
Site Public Contact
Dawnmarie.DeFazio@ahn.org

Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Lankenau Medical Center
Wynnewood 5220230, Pennsylvania 6254927 19096
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

WellSpan Health-York Cancer Center
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957

UPMC Memorial
York 4562407, Pennsylvania 6254927 17408
Contact:
Site Public Contact
717-724-6760

Women and Infants Hospital
Providence 5224151, Rhode Island 5224323 02905
Contact:
Site Public Contact
401-274-1122

Kent Hospital
Warwick 5225507, Rhode Island 5224323 02886
Contact:
Site Public Contact
401-737-7010

Saint Joseph's/Candler - Bluffton Campus
Bluffton 4571722, South Carolina 4597040 29910
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Contact:
Site Public Contact
843-792-9321
hcc-clinical-trials@musc.edu

Saint Francis Cancer Center
Greenville 4580543, South Carolina 4597040 29607
Contact:
Site Public Contact
864-603-6234
Heather_Rich@bshsi.org

Self Regional Healthcare
Greenwood 4580569, South Carolina 4597040 29646
Contact:
Site Public Contact
864-725-4771
nmcgaha@selfregional.org

Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island 4581832, South Carolina 4597040 29926
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Beaufort Memorial/New River Cancer Center
Okatie 4589956, South Carolina 4597040 29909
Contact:
Site Public Contact
843-273-7980

Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Lexington Medical Center
West Columbia 4600541, South Carolina 4597040 29169
Contact:
Site Public Contact
803-935-8300
research@lexhealth.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Houston Methodist San Jacinto Hospital
Baytown 4672731, Texas 4736286 77521
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

MD Anderson in The Woodlands
Conroe 4682991, Texas 4736286 77384
Contact:
Site Public Contact
866-632-6789
askmdanderson@mdanderson.org

Parkland Memorial Hospital
Dallas 4684888, Texas 4736286 75235
Contact:
Site Public Contact
214-590-5582
canceranswerline@UTSouthwestern.edu

UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286 75390
Contact:
Site Public Contact
214-648-7097
canceranswerline@UTSouthwestern.edu

University of Texas Medical Branch
Galveston 4692883, Texas 4736286 77555-0565
Contact:
Site Public Contact
409-772-1950
clinical.research@utmb.edu

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-798-1354
burton@bcm.edu

Ben Taub General Hospital
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-873-2000

Houston Methodist Hospital
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-790-2700

M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Methodist Willowbrook Hospital
Houston 4699066, Texas 4736286 77070
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

MD Anderson West Houston
Houston 4699066, Texas 4736286 77079
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Houston Methodist West Hospital
Houston 4699066, Texas 4736286 77094
Contact:
Site Public Contact
832-522-2873

MD Anderson League City
League City 4705692, Texas 4736286 77573
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Houston Methodist Saint John Hospital
Nassau Bay 4713813, Texas 4736286 77058
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

MD Anderson in Sugar Land
Sugar Land 4734825, Texas 4736286 77478
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Houston Methodist Sugar Land Hospital
Sugar Land 4734825, Texas 4736286 77479
Contact:
Site Public Contact
281-242-2873

Houston Methodist The Woodlands Hospital
The Woodlands 4736476, Texas 4736286 77385
Contact:
Site Public Contact
713-790-2700
hmthewoodlands@houstonmethodist.org

American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork 5844096, Utah 5549030 84003
Contact:
Site Public Contact
801-855-4100
officeofresearch@imail.org

Sandra L Maxwell Cancer Center
Cedar City 5536630, Utah 5549030 84720
Contact:
Site Public Contact
435-868-5680
officeofresearch@imail.org

Farmington Health Center
Farmington 5774662, Utah 5549030 84025
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Logan Regional Hospital
Logan 5777544, Utah 5549030 84321
Contact:
Site Public Contact
435-716-6400
officeofresearch@imail.org

Intermountain Medical Center
Murray 5778755, Utah 5549030 84107
Contact:
Site Public Contact
801-507-3950
officeofresearch@imail.org

McKay-Dee Hospital Center
Ogden 5779206, Utah 5549030 84403
Contact:
Site Public Contact
801-387-7426
officeofresearch@imail.org

Utah Valley Regional Medical Center
Provo 5780026, Utah 5549030 84604
Contact:
Site Public Contact
801-357-7965
officeofresearch@imail.org

Riverton Hospital
Riverton 5780557, Utah 5549030 84065
Contact:
Site Public Contact
801-507-3950
officeofresearch@imail.org

University of Utah Sugarhouse Health Center
Salt Lake City 5780993, Utah 5549030 84106
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

LDS Hospital
Salt Lake City 5780993, Utah 5549030 84143
Contact:
Site Public Contact
801-408-1347
officeofresearch@imail.org

South Jordan Health Center
South Jordan 5781770, Utah 5549030 84009
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Saint George Regional Medical Center
St. George 5546220, Utah 5549030 84770
Contact:
Site Public Contact
833-321-3332
officeofresearch@imail.org

Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners 5233780, Vermont 5242283 05602
Contact:
Site Public Contact
802-225-5400

University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Contact:
Site Public Contact
802-656-4101
rpo@uvm.edu

Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@hitchcock.org

University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928 22908
Contact:
Site Public Contact
434-243-6303
uvacancertrials@hscmail.mcc.virginia.edu

CJW Medical Center - Johnston-Willis Campus
Richmond 4781708, Virginia 6254928 23235
Contact:
Site Public Contact
804-330-2199

Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135 98122
Contact:
Site Public Contact
206-215-2343
PCRC-NCORP@Swedish.org

West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Contact:
Site Public Contact
715-623-9869
Juli.Alford@aspirus.org

Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Bellin Memorial Hospital
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-435-8326

Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-433-8889
WI_research_admin@hshs.org

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468 54601
Contact:
Site Public Contact
608-775-2385
cancerctr@gundersenhealth.org

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100

Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666

Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Contact:
Site Public Contact
research.institute@phci.org

Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468 54017
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505

ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
Contact:
Site Public Contact
715-847-2353
Beth.Knetter@aspirus.org

Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

HSHS Saint Nicholas Hospital
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
920-433-8889
ewd_research_admin@hshs.org

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
Contact:
Site Public Contact
715-847-2353
Beth.Knetter@aspirus.org

Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866

Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505

Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718

More Details

NCT ID
NCT03488693
Status
Recruiting
Sponsor
Canadian Cancer Trials Group

Study Contact

Wendy Parulekar
613-533-6430
wparulekar@ctg.queensu.ca

Detailed Description

Women with node positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. Many women will also receive radiotherapy to the whole breast/chest area and the surrounding lymph glands (called regional radiotherapy). No one really knows whether patients with low risk breast cancer need to receive regional radiotherapy. Some women may be getting regional radiotherapy who do not need it. These women may be exposed to the side effects of their treatment without benefit.