Evaluation of Dosing Procedures of Chemotherapy Treatment (Carboplatin) With the Contrast Agent Iohexol

Purpose

This trial studies how well iohexol works in helping doctors calculate the dose of carboplatin given to patients with cancer. Drugs used in chemotherapy, such as carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Understanding how to best calculate the dose of carboplatin given to patients with cancer may help doctors learn how to improve the use of carboplatin in the future.

Condition

  • Malignant Solid Neoplasm

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
Male
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Patients must have the psychological ability and general health that permits completion of the study requirements and required follow up - For men who are sexually active, the need for use of medically acceptable contraception will be dictated by the primary treatment plan/protocol - Study accrual was closed to women on 08/18/2021 and accrual is now only open to males in order to meet accrual goals and study objectives. (11-AUG-2021) - Male sex - Any patients who will receive treatment with intravenous carboplatin (any AUC, any cycle) on a National Cancer Institute (NCI)-sponsored National Clinical Trial Network (NCTN)-, Experimental Therapeutics Clinical Trials Network (ETCTN)-, trial, local trial, or through standard of care - Age >= 18 - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry

Exclusion Criteria

  • Treated at an institute where creatinine is not measured with an IDMS calibrated assay - History of allergic reactions to computed tomography (CT) contrast, iodine or shellfish, or history of anaphylactic reaction to any food item - Recent (last 6 months) episode of acute kidney injury, have sickle cell disease, or have current indwelling nephrostomy tubes - Edema beyond trace edema, because this will impact iohexol equilibration and distribution - Ascites (including pleural effusion) beyond trace ascites, because this will impact iohexol equilibration and distribution - Whole- or part-limb amputees, because this will impact iohexol equilibration and distribution - Inability to maintain a constant dose and schedule of anti-inflammatory agents, diuretics, angiotensin II receptor blockers (ARB) and angiotensin converting enzyme inhibitors (ACEi) for one week prior to study visit, as this impacts renal function. If the patient is on a nonsteroidal anti-inflammatory drug (NSAID), diuretic, ARB or ACEi, they are eligible as long as these agents are taken on a set schedule for 7 or more days prior to study (and not on an "as needed" basis as that can cause fluctuations in renal function) - Inadequate venous access to obtain pharmacokinetic (PK) specimens - Multinodular goiter, Graves' disease or autoimmune thyroiditis, per iohexol package insert (hypothyroidism is allowed)

Study Design

Phase
Phase 1
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Treatment (iohexol, standard care carboplatin, blood samples) 		Patients receive iohexol IV over 30-60 seconds. Patients then receive standard of care carboplatin IV. Patients also undergo collection of 7-8 blood samples for analysis.
  • Procedure: Biospecimen Collection
    Undergo collection of blood samples
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Drug: Carboplatin
    Given IV
    Other names:
    • Blastocarb
    • Carboplat
    • Carboplatin Hexal
    • Carboplatino
    • Carboplatinum
    • Carbosin
    • Carbosol
    • Carbotec
    • CBDCA
    • Displata
    • Ercar
    • JM-8
    • JM8
    • Nealorin
    • Novoplatinum
    • Paraplatin
    • Paraplatin AQ
    • Paraplatine
    • Platinwas
    • Ribocarbo
  • Drug: Iohexol
    Given IV
    Other names:
    • Omnipaque

Recruiting Locations

University of Arizona Cancer Center-Orange Grove Campus
Tucson 5318313, Arizona 5551752 85704
Contact:
Site Public Contact
520-694-8900

Mercy Hospital Fort Smith
Fort Smith 4111410, Arkansas 4099753 72903
Contact:
Site Public Contact
800-378-9373

CARTI Cancer Center
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-906-4199
Research@CARTI.com

University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274

UC San Diego Health System - Encinitas
Encinitas 5346646, California 5332921 92024
Contact:
Site Public Contact
760-536-7700

UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
Contact:
Site Public Contact
858-822-5354
cancercto@ucsd.edu

University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089

UC San Diego Medical Center - Hillcrest
San Diego 5391811, California 5332921 92103
Contact:
Site Public Contact
rhabbaba@health.ucsd.edu

UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
720-848-0650

Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150

Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah 4221552, Georgia 4197000 31405
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Saint Alphonsus Cancer Care Center-Boise
Boise 5586437, Idaho 5596512 83706
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell 5587698, Idaho 5596512 83605
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512 83814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Idaho Urologic Institute-Meridian
Meridian 5600685, Idaho 5596512 83642
Contact:
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734-712-3671
stephanie.couch@stjoeshealth.org

Saint Alphonsus Cancer Care Center-Nampa
Nampa 5601933, Idaho 5596512 83687
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406-969-6060
mccinfo@mtcancer.org

Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512 83854
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406-969-6060
mccinfo@mtcancer.org

Kootenai Clinic Cancer Services - Sandpoint
Sandpoint 5606401, Idaho 5596512 83864
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406-969-6060
mccinfo@mtcancer.org

OSF Saint Anthony's Health Center
Alton 4232679, Illinois 4896861 62002
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618-463-5623

Saint Mary's Hospital
Centralia 4235587, Illinois 4896861 62801
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412-339-5294
Roster@nrgoncology.org

Northwestern University
Chicago 4887398, Illinois 4896861 60611
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312-695-1301
cancer@northwestern.edu

Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
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800-446-5532
Research@Carle.com

Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
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800-446-5532
Research@carle.com

NorthShore University HealthSystem-Evanston Hospital
Evanston 4891382, Illinois 4896861 60201
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847-570-2109

NorthShore University HealthSystem-Glenbrook Hospital
Glenview 4893886, Illinois 4896861 60026
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847-570-2109

NorthShore University HealthSystem-Highland Park Hospital
Highland Park 4895876, Illinois 4896861 60035
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847-570-2109

Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
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800-446-5532
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SSM Health Good Samaritan
Mount Vernon 4245152, Illinois 4896861 62864
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618-899-1894
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Carle BroMenn Medical Center
Normal 4903780, Illinois 4896861 61761
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800-446-5532
Research@Carle.com

Carle Cancer Institute Normal
Normal 4903780, Illinois 4896861 61761
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800-446-5532
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Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
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800-446-5532
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The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861 61801
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800-446-5532
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Reid Health
Richmond 4263681, Indiana 4921868 47374
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937-528-2900
clinical.trials@daytonncorp.org

UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
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515-241-3305

Saint Anthony Regional Hospital
Carroll 4850478, Iowa 4862182 51401
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515-689-7658
sbenson@iora.org

UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
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515-241-3305

Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
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515-241-6727

UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
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515-241-3305

Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182 50314
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515-282-2200

UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
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515-241-3305

Iowa Lutheran Hospital
Des Moines 4853828, Iowa 4862182 50316
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515-241-8704

Trinity Regional Medical Center
Fort Dodge 4857486, Iowa 4862182 50501
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515-574-8302

UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
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515-241-3305

Methodist West Hospital
West Des Moines 4881346, Iowa 4862182 50266-7700
Contact:
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515-343-1000

Central Care Cancer Center - Garden City
Garden City 5445439, Kansas 4273857 67846
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

Central Care Cancer Center - Great Bend
Great Bend 4272340, Kansas 4273857 67530
Contact:
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913-948-5588
aroland@kccop.org

Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885 21287
Contact:
Site Public Contact
410-955-8804
jhcccro@jhmi.edu

Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885 20889-5600
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301-319-2100

Baystate Medical Center
Springfield 4951788, Massachusetts 6254926 01199
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413-794-3565
tamara.wrenn@baystatehealth.org

Saint Louis Cancer and Breast Institute-Ballwin
Ballwin 4375663, Missouri 4398678 63011
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314-251-7058

Central Care Cancer Center - Bolivar
Bolivar 4377835, Missouri 4398678 65613
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913-948-5588
aroland@kccop.org

Cox Cancer Center Branson
Branson 4378219, Missouri 4398678 65616
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417-269-4520

Mercy Cancer Center - Cape Girardeau
Cape Girardeau 4379966, Missouri 4398678 63703
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888-446-3729

Freeman Health System
Joplin 4392768, Missouri 4398678 64804
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417-347-4030
LJCrockett@freemanhealth.com

Mercy Hospital Joplin
Joplin 4392768, Missouri 4398678 64804
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417-556-3074
esmeralda.carrillo@mercy.net

Lake Regional Hospital
Osage Beach 4402040, Missouri 4398678 65065
Contact:
Site Public Contact
573-302-2768
clinicaltrials@lakeregional.com

Mercy Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-6379

Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-7504
research@phelpshealth.org

Heartland Regional Medical Center
Saint Joseph 4407010, Missouri 4398678 64506
Contact:
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816-271-7937
Trisha.England2@mymlc.com

Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Contact:
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417-269-4520

CoxHealth South Hospital
Springfield 4409896, Missouri 4398678 65807
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417-269-4520

Saint Louis Cancer and Breast Institute-South City
St Louis 4407066, Missouri 4398678 63109
Contact:
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314-353-1870

Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
Contact:
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314-525-6042
Danielle.Werle@mercy.net

Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
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314-251-7066

Mercy Hospital Washington
Washington 4413621, Missouri 4398678 63090
Contact:
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636-390-1600

Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009 59711
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Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
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Site Public Contact
800-996-2663
research@billingsclinic.org

Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
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Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Great Falls Clinic
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Hi-Line Sletten Cancer Center
Havre 5656497, Montana 5667009 59501
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Logan Health Medical Center
Kalispell 5660340, Montana 5667009 59901
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406-969-6060
mccinfo@mtcancer.org

Community Medical Center
Missoula 5666639, Montana 5667009 59804
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406-969-6060
mccinfo@mtcancer.org

Women's Cancer Center of Nevada
Las Vegas 5506956, Nevada 5509151 89106
Contact:
Site Public Contact
702-851-4672

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@dartmouth.edu

Memorial Sloan Kettering Basking Ridge
Basking Ridge 5095409, New Jersey 5101760 07920
Contact:
Site Public Contact
212-639-7592

Jefferson Cherry Hill Hospital
Cherry Hill 4501198, New Jersey 5101760 08002
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
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Site Public Contact
212-639-7592

Memorial Sloan Kettering Bergen
Montvale 5101361, New Jersey 5101760 07645
Contact:
Site Public Contact
212-639-7592

Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356

Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Contact:
Site Public Contact
908-685-2481
Siby.Varughese@rwjbh.org

Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Contact:
Site Public Contact
800-767-9355
askroswell@roswellpark.org

Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
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Site Public Contact
212-639-7592

The Cancer Institute at Saint Francis Hospital
East Hills 5115904, New York 5128638 11548
Contact:
Site Public Contact
516-325-7514
Stephanie.Solito@chsli.org

Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592

Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592

Highland Hospital
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Memorial Sloan Kettering Nassau
Uniondale 5141927, New York 5128638 11553
Contact:
Site Public Contact
212-639-7592

Good Samaritan University Hospital
West Islip 5143866, New York 5128638 11795
Contact:
Site Public Contact
516-326-7514

Indu and Raj Soin Medical Center
Beavercreek 4506008, Ohio 5165418 45431
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC-Miami Valley South
Centerville 4508204, Ohio 5165418 45459
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Cincinnati Cancer Center-UC Medical Center
Cincinnati 4508722, Ohio 5165418 45219
Contact:
Site Public Contact
513-584-7698
cancer@uchealth.com

Oncology Hematology Care Inc-Kenwood
Cincinnati 4508722, Ohio 5165418 45236
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physician LLC - Englewood
Dayton 4509884, Ohio 5165418 45415
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Armes Family Cancer Center
Findlay 5153924, Ohio 5165418 45840
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Blanchard Valley Hospital
Findlay 5153924, Ohio 5165418 45840
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Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Orion Cancer Care
Findlay 5153924, Ohio 5165418 45840
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
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Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC-Atrium
Franklin 4512203, Ohio 5165418 45005
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC-Wayne
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515

Wayne Hospital
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Greater Dayton Cancer Center
Kettering 4515843, Ohio 5165418 45409
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Kettering Medical Center
Kettering 4515843, Ohio 5165418 45429
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Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC - Troy
Troy 5174358, Ohio 5165418 45373
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Cincinnati Cancer Center-West Chester
West Chester 4520522, Ohio 5165418 45069
Contact:
Site Public Contact
513-584-7698
cancer@uchealth.com

Saint Elizabeth Youngstown Hospital
Youngstown 5177568, Ohio 5165418 44501
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Mercy Hospital Oklahoma City
Oklahoma City 4544349, Oklahoma 4544379 73120
Contact:
Site Public Contact
405-752-3402

Saint Alphonsus Cancer Care Center-Baker City
Baker City 5712169, Oregon 5744337 97814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Alphonsus Cancer Care Center-Ontario
Ontario 5744166, Oregon 5744337 97914
Contact:
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406-969-6060
mccinfo@mtcancer.org

Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073

Women and Infants Hospital
Providence 5224151, Rhode Island 5224323 02905
Contact:
Site Public Contact
401-274-1122

Vanderbilt-Ingram Cancer Center at Franklin
Franklin 4623560, Tennessee 4662168 37067
Contact:
Site Public Contact
800-811-8480

Vanderbilt-Ingram Cancer Center Cool Springs
Franklin 4623560, Tennessee 4662168 37067
Contact:
Site Public Contact
800-811-8480

Vanderbilt Breast Center at One Hundred Oaks
Nashville 4644585, Tennessee 4662168 37204
Contact:
Site Public Contact
800-811-8480

Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168 37232
Contact:
Site Public Contact
800-811-8480

University of Utah Sugarhouse Health Center
Salt Lake City 5780993, Utah 5549030 84106
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666

Billings Clinic-Cody
Cody 5821593, Wyoming 5843591 82414
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Cancer Center-Metro Medical Center Bayamon
Bayamón 4562831, Puerto Rico 00959-5060
Contact:
Site Public Contact
787-395-7085

Puerto Rico Hematology Oncology Group
Bayamón 4562831, Puerto Rico 00961
Contact:
Site Public Contact
787-780-2865

Doctors Cancer Center
Manatí 4566137, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397

San Juan Community Oncology Group
San Juan 4568127, Puerto Rico 00917
Contact:
Site Public Contact
787-274-3387

Centro Comprensivo de Cancer de UPR
San Juan 4568127, Puerto Rico 00927
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

PROncology
San Juan 4568127, Puerto Rico 00927
Contact:
Site Public Contact
787-919-7919
info@PRoncology.com

San Juan City Hospital
San Juan 4568127, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296

More Details

NCT ID
NCT03997370
Status
Recruiting
Sponsor
NRG Oncology

Detailed Description

PRIMARY OBJECTIVES: I. Evaluate the success of targeting a carboplatin area under the curve (AUC) with our current approach to dosing carboplatin. II. Assess the performance of Cockcroft-Gault (CG), four-variable Modification of Diet in Renal Disease (MDRD-4), and Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) based on isotope dilution mass spectrometry (IDMS) calibrated serum creatinine in predicting measured glomerular filtration rate (mGFR) in patients with cancer. III. Define the relationship of mGFR and carboplatin clearance in patients with cancer. SECONDARY OBJECTIVES: I. Evaluate the divergence of estimated (e)GFR from mGFR based on patient demographic and other characteristics, thus identifying those most likely to benefit from determination of mGFR over use of eGFR. II. Determine the success rate of achieving the target carboplatin AUC in patients in whom the carboplatin dose is capped. III. Evaluate the relationship between carboplatin exposure and toxicity. IV. Assess the ability of markers other than creatinine in pre-treatment serum to better estimate kidney function in patients with cancer. OUTLINE: Patients receive iohexol intravenously (IV) over 30-60 seconds. Patients then receive standard of care carboplatin IV. Patients also undergo collection of 7-8 blood samples for analysis. After completion of study, patients are followed up for 3-4 weeks.