Two Studies for Patients With High Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a High Gene Risk Score, The PREDICT-RT Trial

Purpose

This phase III trial compares less intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in treating patients with high risk prostate cancer and low gene risk score. This trial also compares more intense hormone therapy and radiation therapy to usual hormone therapy and radiation therapy in patients with high risk prostate cancer and high gene risk score. Apalutamide may help fight prostate cancer by blocking the use of androgen by the tumor cells. Radiation therapy uses high energy rays to kill tumor cells and shrink tumors. Giving a shorter hormone therapy treatment may work the same at controlling prostate cancer compared to the usual 24 month hormone therapy treatment in patients with low gene risk score. Adding apalutamide to the usual treatment may increase the length of time without prostate cancer spreading as compared to the usual treatment in patients with high gene risk score.

Conditions

  • Prostate Adenocarcinoma
  • Stage III Prostate Cancer AJCC v8
  • Stage IVA Prostate Cancer AJCC v8

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
Male
Accepts Healthy Volunteers
No

Inclusion Criteria

  • PRIOR TO STEP 1 REGISTRATION - Pathologically proven diagnosis of adenocarcinoma of prostate cancer within 180 days prior to registration - High-risk disease defined as having at least one or more of the following: - PSA > 20 ng/mL prior to starting ADT - Note: Patients receiving a 5-alpha reductase inhibitor (ex. finasteride) at the time of enrollment are eligible. The baseline PSA value should be doubled for PSAs taken while on 5-alpha reductase inhibitors and the medication should be discontinued prior to randomization but a washout period is not required - cT3a-T4 by digital exam or imaging (American Joint Committee on Cancer [AJCC] 8th edition [Ed.]) - Gleason score of 8-10 - Node positive by conventional imaging with a short axis of at least 1.0 cm - Appropriate stage for study entry based on the following diagnostic workup: - History/physical examination within 120 days prior to registration; - Bone imaging within 120 days prior to registration; - Note: To be eligible, patient must have no definitive evidence of bone metastases (M0) on bone scan or sodium fluoride (NaF) PET within 120 days prior to registration (negative NaF PET/CT or negative Axumin or choline PET or negative fluciclovine, choline or prostate-specific membrane antigen (PSMA) PET within 120 days prior to registration is an acceptable substitute if they have been performed). Patients who have bone metastases established only fluciclovine, choline, or PSMA PET but not definitive on bone scan or NaF PET will still be eligible - CT or MRI of the pelvis within 120 days prior to registration (negative fluciclovine, choline, or PSMA PET within 120 days prior to registration is an acceptable substitute). As with bone staging, nodal staging for trial purposes will be based off of conventional imaging findings only - Patients with confirmed N1 metastases on conventional imaging (CT/MRI) as defined by >= 10 mm on short axis are eligible but will be automatically assigned to the intensification study. Patients who are positive by fluciclovine, choline, or PSMA PET (i.e. N1), but whose nodes do not meet traditional size criteria for positivity (i.e. they measure >= 10 mm on either the CT or MRI portion of the PET or on a dedicated CT or MRI) will not be considered N1 for the trial and will not automatically be assigned to the intensification study - Age >= 18 - Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 120 days prior to registration - Hemoglobin >= 9.0 g/dL, independent of transfusion and/or growth factors (within 120 days prior to registration) - Platelet count >= 100 x 10^3/uL independent of transfusion and/or growth factors (within 120 days prior to registration) - Creatinine clearance (CrCl) >= 30 mL/min estimated by Cockcroft-Gault equation (within 120 days prior to registration) - For Black patients whose renal function is not considered adequate by Cockcroft-Gault formula, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) may be used for calculating creatinine clearance for trial eligibility - Either a CrCl >= 30 ml/min or calculated glomerular filtration rate (GFR) >= 30 will make a patient eligible - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (within 120 days prior to registration) - Note: In subjects with Gilbert's syndrome, if total bilirubin is > 1.5 x ULN, measure direct and indirect bilirubin and if direct bilirubin is =< 1.5 x ULN, subject is eligible - Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT]) or alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x institutional ULN (within 120 days prior to registration) - Serum albumin >= 3.0 g/dL (within 120 days prior to registration) - The patient must agree to use a condom (even men with vasectomies) and another effective method of birth control if he is having sex with a woman of childbearing potential or agree to use a condom if he is having sex with a woman who is pregnant while on study drug and for 3 months following the last dose of study drug - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial and have a CD4 count >= 200 cells/microliter within 60 days prior to registration. Note: HIV testing is not required for eligibility for this protocol. Of note, for patients with HIV in the intensification trial randomized to apalutamide, highly active antiretroviral therapy (HAART) may need to be adjusted to medications that do not interact with apalutamide - For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable after or on suppressive therapy within 60 days prior to registration, if indicated. Note: HBV viral testing is not required for eligibility for this protocol - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial. Note: Any patient with a cancer (other than keratinocyte carcinoma or carcinoma in situ or low-grade non-muscle invasive bladder cancer) who has been disease-free for less than 3 years must contact the principal investigator - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry - PRIOR TO STEP 2 RANDOMIZATION - Confirmation of Decipher score - Patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load within 60 days prior. Note: Apalutamide may interfere with HCV drugs. Patients on HCV medications should alert their infectious diseases physician if they get randomized to apalutamide due to the possibility that apalutamide can affect the bioavailability of some HCV medications. HCV viral testing is not required for eligibility for this protocol - For patients entering the Intensification Cohort ONLY: Patients must discontinue or substitute concomitant medications known to lower the seizure threshold at least 30 days prior to Step 2 randomization

Exclusion Criteria

  • PRIOR TO STEP 1 REGISTRATION: - Definitive radiologic evidence of metastatic disease outside of the pelvic nodes (M1a, M1b or M1c) on conventional imaging (i.e. bone scan, CT scan, MRI) - Prior systemic chemotherapy within =< 3 years prior to registration; note that prior chemotherapy for a different cancer is allowed (completed > 3 years prior to registration - Prior radical prostatectomy - Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields - Current use of 5-alpha reductase inhibitor. NOTE: If the alpha reductase inhibitor is stopped prior to randomization the patient is eligible - History of any of the following: - Seizure disorder - Current severe or unstable angina - New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.) - History of any condition that in the opinion of the investigator, would preclude participation in this study - Evidence of any of the following at registration: - Active uncontrolled infection requiring IV antibiotics - Baseline severe hepatic impairment (Child Pugh Class C) - Inability to swallow oral pills - Any current condition that in the opinion of the investigator, would preclude participation in this study - Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both luteinizing hormone-releasing hormone [LHRH] agonist and oral anti-androgen) is =< 60 days prior to registration; Please note: baseline PSA must be obtained prior to the start of any ADT - PRIOR TO STEP 2 RANDOMIZATION: - Evidence of known gastrointestinal disorder affecting absorption of oral medications at registration - For patients entering the Intensification Cohort ONLY: Presence of uncontrolled hypertension (persistent systolic blood pressure [BP] >= 160 mmHg or diastolic BP >= 100 mmHg). Subjects with a history of hypertension are allowed, provided that BP is controlled to within these limits by anti-hypertensive treatment

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Arm I (de-intensification study) 		Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 24 months in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.
  • Drug: Bicalutamide
    Given bicalutamide
    Other names:
    • Casodex
    • Cassotide
    • Cosudex
    • ICI 176,334
    • ICI 176334
    • Utamide
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Procedure: Bone Scan
    Undergo bone scan
    Other names:
    • Bone Scintigraphy
  • Drug: Buserelin
    Given buserelin
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Procedure: Computed Tomography
    Undergo CT scan
    Other names:
    • CAT
    • CAT Scan
    • Computed Axial Tomography
    • Computerized Axial Tomography
    • Computerized axial tomography (procedure)
    • Computerized Tomography
    • Computerized Tomography (CT) scan
    • CT
    • CT Scan
    • tomography
  • Drug: Degarelix
    Given degarelix
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Flutamide
    Given flutamide
    Other names:
    • 4'-Nitro-3'-trifluoromethylisobutyranilide
    • Apimid
    • Cebatrol
    • Chimax
    • Cytomid
    • Drogenil
    • Euflex
    • Eulexine
    • Flucinom
    • Flucinome
    • Flugerel
    • Fluken
    • Flulem
    • FLUT
    • Fluta-Gry
    • Flutabene
    • Flutacan
    • Flutamex
    • Flutamin
    • Flutan
    • Flutaplex
    • Fugerel
    • Grisetin
    • Niftolide
    • Oncosal
    • Profamid
    • Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
    • Prostacur
    • Prostadirex
    • Prostica
    • Prostogenat
    • Sch 13521
    • Tafenil
    • Tecnoflut
    • Testotard
  • Drug: Goserelin
    Given goserelin
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Given histrelin
  • Drug: Leuprolide
    Given leuprolide
    Other names:
    • Leuprorelin
  • Procedure: Magnetic Resonance Elastography
    Undergo MRI
    Other names:
    • MRE
  • Procedure: Positron Emission Tomography
    Undergo PET scan
    Other names:
    • Medical Imaging, Positron Emission Tomography
    • PET
    • PET Scan
    • Positron emission tomography (procedure)
    • Positron Emission Tomography Scan
    • Positron-Emission Tomography
    • PT
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Given relugolix
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Given triptorelin
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline
Experimental
Arm II (de-intensification study) 		Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 12 months in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.
  • Drug: Bicalutamide
    Given bicalutamide
    Other names:
    • Casodex
    • Cassotide
    • Cosudex
    • ICI 176,334
    • ICI 176334
    • Utamide
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Procedure: Bone Scan
    Undergo bone scan
    Other names:
    • Bone Scintigraphy
  • Drug: Buserelin
    Given buserelin
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Procedure: Computed Tomography
    Undergo CT scan
    Other names:
    • CAT
    • CAT Scan
    • Computed Axial Tomography
    • Computerized Axial Tomography
    • Computerized axial tomography (procedure)
    • Computerized Tomography
    • Computerized Tomography (CT) scan
    • CT
    • CT Scan
    • tomography
  • Drug: Degarelix
    Given degarelix
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Flutamide
    Given flutamide
    Other names:
    • 4'-Nitro-3'-trifluoromethylisobutyranilide
    • Apimid
    • Cebatrol
    • Chimax
    • Cytomid
    • Drogenil
    • Euflex
    • Eulexine
    • Flucinom
    • Flucinome
    • Flugerel
    • Fluken
    • Flulem
    • FLUT
    • Fluta-Gry
    • Flutabene
    • Flutacan
    • Flutamex
    • Flutamin
    • Flutan
    • Flutaplex
    • Fugerel
    • Grisetin
    • Niftolide
    • Oncosal
    • Profamid
    • Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
    • Prostacur
    • Prostadirex
    • Prostica
    • Prostogenat
    • Sch 13521
    • Tafenil
    • Tecnoflut
    • Testotard
  • Drug: Goserelin
    Given goserelin
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Given histrelin
  • Drug: Leuprolide
    Given leuprolide
    Other names:
    • Leuprorelin
  • Procedure: Magnetic Resonance Elastography
    Undergo MRI
    Other names:
    • MRE
  • Procedure: Positron Emission Tomography
    Undergo PET scan
    Other names:
    • Medical Imaging, Positron Emission Tomography
    • PET
    • PET Scan
    • Positron emission tomography (procedure)
    • Positron Emission Tomography Scan
    • Positron-Emission Tomography
    • PT
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Given relugolix
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Given triptorelin
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline
Active Comparator
Arm III (intensification study) 		Patients undergo RT over 2-11 weeks and receive ADT as in Arm I. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.
  • Drug: Bicalutamide
    Given bicalutamide
    Other names:
    • Casodex
    • Cassotide
    • Cosudex
    • ICI 176,334
    • ICI 176334
    • Utamide
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Procedure: Bone Scan
    Undergo bone scan
    Other names:
    • Bone Scintigraphy
  • Drug: Buserelin
    Given buserelin
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Procedure: Computed Tomography
    Undergo CT scan
    Other names:
    • CAT
    • CAT Scan
    • Computed Axial Tomography
    • Computerized Axial Tomography
    • Computerized axial tomography (procedure)
    • Computerized Tomography
    • Computerized Tomography (CT) scan
    • CT
    • CT Scan
    • tomography
  • Drug: Degarelix
    Given degarelix
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Flutamide
    Given flutamide
    Other names:
    • 4'-Nitro-3'-trifluoromethylisobutyranilide
    • Apimid
    • Cebatrol
    • Chimax
    • Cytomid
    • Drogenil
    • Euflex
    • Eulexine
    • Flucinom
    • Flucinome
    • Flugerel
    • Fluken
    • Flulem
    • FLUT
    • Fluta-Gry
    • Flutabene
    • Flutacan
    • Flutamex
    • Flutamin
    • Flutan
    • Flutaplex
    • Fugerel
    • Grisetin
    • Niftolide
    • Oncosal
    • Profamid
    • Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
    • Prostacur
    • Prostadirex
    • Prostica
    • Prostogenat
    • Sch 13521
    • Tafenil
    • Tecnoflut
    • Testotard
  • Drug: Goserelin
    Given goserelin
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Given histrelin
  • Drug: Leuprolide
    Given leuprolide
    Other names:
    • Leuprorelin
  • Procedure: Magnetic Resonance Elastography
    Undergo MRI
    Other names:
    • MRE
  • Procedure: Positron Emission Tomography
    Undergo PET scan
    Other names:
    • Medical Imaging, Positron Emission Tomography
    • PET
    • PET Scan
    • Positron emission tomography (procedure)
    • Positron Emission Tomography Scan
    • Positron-Emission Tomography
    • PT
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Given relugolix
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Given triptorelin
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline
Experimental
Arm IV (intensification study) 		Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix) for 24 months in the absence of disease progression or unacceptable toxicity. Patients also receive apalutamide PO QD. Treatment repeats every 90 days for up to 8 cycles (24 months) in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, PET scan, CT scan, and MRI at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.
  • Drug: Apalutamide
    Given PO
    Other names:
    • ARN 509
    • ARN-509
    • ARN509
    • Erleada
    • JNJ 56021927
    • JNJ-56021927
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Procedure: Bone Scan
    Undergo bone scan
    Other names:
    • Bone Scintigraphy
  • Drug: Buserelin
    Given buserelin
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Procedure: Computed Tomography
    Undergo CT scan
    Other names:
    • CAT
    • CAT Scan
    • Computed Axial Tomography
    • Computerized Axial Tomography
    • Computerized axial tomography (procedure)
    • Computerized Tomography
    • Computerized Tomography (CT) scan
    • CT
    • CT Scan
    • tomography
  • Drug: Degarelix
    Given degarelix
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Goserelin
    Given goserelin
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Given histrelin
  • Drug: Leuprolide
    Given leuprolide
    Other names:
    • Leuprorelin
  • Procedure: Magnetic Resonance Elastography
    Undergo MRI
    Other names:
    • MRE
  • Procedure: Positron Emission Tomography
    Undergo PET scan
    Other names:
    • Medical Imaging, Positron Emission Tomography
    • PET
    • PET Scan
    • Positron emission tomography (procedure)
    • Positron Emission Tomography Scan
    • Positron-Emission Tomography
    • PT
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Given relugolix
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Given triptorelin
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline

Recruiting Locations

Fairbanks Memorial Hospital
Fairbanks 5861897, Alaska 5879092 99701
Contact:
Site Public Contact
907-458-3043
Veronica.Stevenson@foundationhealth.org

Arizona Center for Cancer Care - Gilbert
Gilbert 5295903, Arizona 5551752 85297
Contact:
Site Public Contact
480-278-8261
penny.labriola@arizonaccc.com

Arizona Center for Cancer Care-Peoria
Peoria 5308480, Arizona 5551752 85381
Contact:
Site Public Contact
623-773-2873

Arizona Center for Cancer Care - Phoenix
Phoenix 5308655, Arizona 5551752 85027
Contact:
Site Public Contact
480-278-8261
penny.labriola@arizonaccc.com

University of Arizona Cancer Center-North Campus
Tucson 5318313, Arizona 5551752 85719
Contact:
Site Public Contact
UACC-IIT@uacc.arizona.edu

University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274

Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn 5325223, California 5332921 95603
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

AIS Cancer Center at San Joaquin Community Hospital
Bakersfield 5325738, California 5332921 93301
Contact:
Site Public Contact
661-323-4673

Alta Bates Summit Medical Center-Herrick Campus
Berkeley 5327684, California 5332921 94704
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park 5333282, California 5332921 95682
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

City of Hope Corona
Corona 5339631, California 5332921 92882
Contact:
Site Public Contact
626-256-4673
becomingapatient@coh.org

City of Hope Comprehensive Cancer Center
Duarte 5344147, California 5332921 91010
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691

UC San Diego Health System - Encinitas
Encinitas 5346646, California 5332921 92024
Contact:
Site Public Contact
760-536-7700

Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Palo Alto Medical Foundation-Fremont
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Washington Hospital
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
510-745-6433

Kaiser Permanente-Fresno
Fresno 5350937, California 5332921 93720
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Marin General Hospital
Greenbrae 5354013, California 5332921 94904
Contact:
Site Public Contact
415-925-7325

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921 92612
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

City of Hope at Irvine Lennar
Irvine 5359777, California 5332921 92618
Contact:
Site Public Contact
877-467-3411

UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
Contact:
Site Public Contact
858-822-5354
cancercto@ucsd.edu

City of Hope Antelope Valley
Lancaster 5364940, California 5332921 93534
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965

Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400

Memorial Medical Center
Modesto 5373900, California 5332921 95355
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Providence Queen of The Valley
Napa 5376095, California 5332921 94558
Contact:
Site Public Contact
707-521-3830

Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Saint Joseph Hospital - Orange
Orange 5379513, California 5332921 92868
Contact:
Site Public Contact
714-734-6220

UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921 92868
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Stanford Cancer Institute Palo Alto
Palo Alto 5380748, California 5332921 94304
Contact:
Site Public Contact
650-498-7061
ccto-office@stanford.edu

Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Contact:
Site Public Contact
877-642-4691
kpoct@kp.org

Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089

Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

California Protons Cancer Therapy Center
San Diego 5391811, California 5332921 92121
Contact:
Site Public Contact
858-299-5982

Sharp Memorial Hospital
San Diego 5391811, California 5332921 92123
Contact:
Site Public Contact
858-939-5062
cathy.wood@sharp.com

Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921 94158
Contact:
Site Public Contact
877-827-3222
cancertrials@ucsf.edu

Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Stanford Cancer Center South Bay
San Jose 5392171, California 5332921 95124
Contact:
Site Public Contact
650-498-7061
ccto-office@stanford.edu

Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

UCSF Cancer Center - San Mateo
San Mateo 5392423, California 5332921 94402
Contact:
Site Public Contact
877-827-3222
cancertrials@ucsf.edu

Ridley-Tree Cancer Center
Santa Barbara 5392952, California 5332921 93105
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

City of Hope South Pasadena
South Pasadena 5397717, California 5332921 91030
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Cedars-Sinai Cancer - Tarzana
Tarzana 5401143, California 5332921 91356
Contact:
Site Public Contact
818-981-3818

City of Hope South Bay
Torrance 5403022, California 5332921 90503
Contact:
Site Public Contact
877-467-3411

Torrance Memorial Physician Network - Cancer Care
Torrance 5403022, California 5332921 90505
Contact:
Site Public Contact
310-750-3300
courtney.steeneken@tmphysicians.com

Torrance Memorial Medical Center
Torrance 5403022, California 5332921 90509
Contact:
Site Public Contact
310-517-4665

Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee 5403676, California 5332921 96161
Contact:
Site Public Contact
530-582-6450

City of Hope Upland
Upland 5404915, California 5332921 91786
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

BASS Medical Group - Lennon
Walnut Creek 5406990, California 5332921 94598
Contact:
Site Public Contact
307-760-7636
brenna.lindsey@bassmedicalgroup.com

John Muir Medical Center-Walnut Creek
Walnut Creek 5406990, California 5332921 94598
Contact:
Site Public Contact
925-941-4246
clinicalresearch@johnmuirhealth.com

UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
720-848-0650

Rocky Mountain Cancer Centers-Boulder
Boulder 5574991, Colorado 5417618 80304
Contact:
Site Public Contact
303-777-2663
info@westernstatesncorp.org

UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
Contact:
Site Public Contact
719-365-2406

Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
Contact:
Site Public Contact
719-364-6700

Shaw Cancer Center
Edwards 5420885, Colorado 5417618 81632
Contact:
Site Public Contact
970-569-7429

Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150

Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Saint Mary's Hospital and Regional Medical Center
Grand Junction 5423573, Colorado 5417618 81501
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Banner North Colorado Medical Center
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
970-810-3046
BMDACCResearchCOMailbox@bannerhealth.com

UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UCHealth Highlands Ranch Hospital
Highlands Ranch 5425043, Colorado 5417618 80129
Contact:
Site Public Contact
720-848-0650

Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083

Banner McKee Medical Center
Loveland 5579368, Colorado 5417618 80539
Contact:
Site Public Contact
970-810-3046
BMDACCResearchCOMailbox@bannerhealth.com

Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport 5282804, Connecticut 4831725 06606
Contact:
Site Public Contact
860-972-4700

Smilow Cancer Hospital-Derby Care Center
Derby 4832745, Connecticut 4831725 06418
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center-Fairfield
Fairfield 4834157, Connecticut 4831725 06824
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center at Greenwich
Greenwich 4835395, Connecticut 4831725 06830
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center - Guilford
Guilford 4835512, Connecticut 4831725 06437
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Hartford Hospital
Hartford 4835797, Connecticut 4831725 06102
Contact:
Site Public Contact
860-545-5363

Smilow Cancer Hospital Care Center at Saint Francis
Hartford 4835797, Connecticut 4831725 06105
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Midstate Medical Center
Meriden 4838524, Connecticut 4831725 06451
Contact:
Site Public Contact
866-662-5678

The Hospital of Central Connecticut
New Britain 4839292, Connecticut 4831725 06050
Contact:
Site Public Contact
860-224-5660

Yale University
New Haven 4839366, Connecticut 4831725 06520
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Yale-New Haven Hospital North Haven Medical Center
North Haven 4839704, Connecticut 4831725 06473
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital-Orange Care Center
Orange 4840104, Connecticut 4831725 06477
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center at Long Ridge
Stamford 4843564, Connecticut 4831725 06902
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Stamford Hospital/Bennett Cancer Center
Stamford 4843564, Connecticut 4831725 06904
Contact:
Site Public Contact
203-323-8944

Smilow Cancer Hospital Care Center-Trumbull
Trumbull 4844459, Connecticut 4831725 06611
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center - Waterford
Waterford 8480031, Connecticut 4831725 06385
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Bayhealth Hospital Kent Campus
Dover 4142290, Delaware 4142224 19901
Contact:
Site Public Contact
302-674-4401
clinical_trials@bayhealth.org

Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Mount Sinai Comprehensive Cancer Center at Aventura
Aventura 4146429, Florida 4155751 33180
Contact:
Site Public Contact
305-674-2625
yenrique@msmc.com

Boca Raton Regional Hospital
Boca Raton 4148411, Florida 4155751 33486
Contact:
Site Public Contact
561-955-4800

University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751 32610
Contact:
Site Public Contact
352-273-8010
cancer-center@ufl.edu

Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751 32224-9980
Contact:
Site Public Contact
855-776-0015

Miami Cancer Institute
Miami 4164138, Florida 4155751 33176
Contact:
Site Public Contact
786-596-2000

Mount Sinai Medical Center
Miami Beach 4164143, Florida 4155751 33140
Contact:
Site Public Contact
305-674-2625
yenrique@msmc.com

Miami Cancer Institute at Plantation
Plantation 4168782, Florida 4155751 33324
Contact:
Site Public Contact
954-837-1490

Tampa General Hospital
Tampa 4174757, Florida 4155751 33606
Contact:
Site Public Contact
813-844-7829
syapchanyk@tgh.org

Grady Health System
Atlanta 4180439, Georgia 4197000 30303
Contact:
Site Public Contact
404-778-1868

Emory Proton Therapy Center
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
404-251-2854
allyson.anderson@emory.edu

Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
888-946-7447

Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000 30322
Contact:
Site Public Contact
404-778-1868

Emory Saint Joseph's Hospital
Atlanta 4180439, Georgia 4197000 30342
Contact:
Site Public Contact
404-851-7115

Emory Decatur Hospital
Decatur 4191124, Georgia 4197000 30033
Contact:
Site Public Contact
440-778-1868
clinicaltrialsoncology@dekalbmedical.org

Emory Johns Creek Hospital
Johns Creek 6331909, Georgia 4197000 30097
Contact:
Site Public Contact
404-778-5714
m.lisa.hwang@emory.edu

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah 4221552, Georgia 4197000 31405
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-524-6115
i.webster@hawaiicancercare.com

Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-532-0315

Queen's Medical Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-545-8548

Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-522-4333

University of Hawaii Cancer Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-586-2979

Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-531-8521

The Cancer Center of Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-6881

Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-539-2273
info@hawaiicancercare.com

Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-486-6000

The Cancer Center of Hawaii-Pali Momi
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-678-9000

The Queen's Medical Center - West Oahu
‘Ewa Beach 5855051, Hawaii 5855797 96706
Contact:
Site Public Contact
rohta@queens.org

Alton Memorial Hospital
Alton 4232679, Illinois 4896861 62002
Contact:
Site Public Contact
618-463-7323

Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847

Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern University
Chicago 4887398, Illinois 4896861 60611
Contact:
Site Public Contact
312-695-1301
cancer@northwestern.edu

Rush University Medical Center
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-942-5498
clinical_trials@rush.edu

University of Illinois
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046

University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360

AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocate.com

Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Contact:
Site Public Contact
630-275-1270
Barbara.barhamand@advocatehealth.com

Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907

Elmhurst Memorial Hospital
Elmhurst 4891010, Illinois 4896861 60126
Contact:
Site Public Contact
630-758-5460
Jrohde@emhc.org

Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Northwestern Medicine Glenview Outpatient Center
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
312-695-1102

Northwestern Medicine Grayslake Outpatient Center
Grayslake 4894465, Illinois 4896861 60030
Contact:
Site Public Contact
312-695-1102

Ingalls Memorial Hospital
Harvey 4895298, Illinois 4896861 60426
Contact:
Site Public Contact
708-915-4673
clinicaltrials@ingalls.org

Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995

Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861 60045
Contact:
Site Public Contact
cancertrials@northwestern.edu

AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Loyola University Medical Center
Maywood 4901514, Illinois 4896861 60153
Contact:
Site Public Contact
708-226-4357

Edward Hospital/Cancer Center
Naperville 4903279, Illinois 4896861 60540
Contact:
Site Public Contact
630-646-6075

UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861 60451
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Oak Brook
Oak Brook 4904277, Illinois 4896861 60523
Contact:
Site Public Contact
nctnprogram_rhlccc@northwestern.edu

Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622

Northwestern Medicine Orland Park
Orland Park 4904937, Illinois 4896861 60462
Contact:
Site Public Contact
nctnprogram_rhlccc@northwestern.edu

University of Chicago Medicine-Orland Park
Orland Park 4904937, Illinois 4896861 60462
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Advocate High Tech Medical Park
Palos Heights 4905259, Illinois 4896861 60463
Contact:
Site Public Contact
ncorp@aah.org

Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621

Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861 61637
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Edward Hospital/Cancer Center?Plainfield
Plainfield 4906125, Illinois 4896861 60585
Contact:
Site Public Contact
630-646-6075
Cancerresearch@edward.org

Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Memorial Hospital East
Shiloh 4249910, Illinois 4896861 62269
Contact:
Site Public Contact
314-747-9912
dschwab@wustl.edu

Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Contact:
Site Public Contact
217-528-7541
pallante.beth@mhsil.com

Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

IU Health West Hospital
Avon 4254021, Indiana 4921868 46123
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

IU Health North Hospital
Carmel 4255466, Indiana 4921868 46032
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

UChicago Medicine Northwest Indiana
Crown Point 4919451, Indiana 4921868 46307
Contact:
Site Public Contact
855-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis 4259418, Indiana 4921868 46202
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

IU Health Methodist Hospital
Indianapolis 4259418, Indiana 4921868 46202
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305

Saint Luke's Hospital
Cedar Rapids 4850751, Iowa 4862182 52402
Contact:
Site Public Contact
319-368-5514
Rachel.varner@unitypoint.org

Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673

Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690

Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727

UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305

Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-282-2200

University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Contact:
Site Public Contact
913-588-1569
OlatheCCResearch@kumc.edu

University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Contact:
Site Public Contact
785-452-7038
mleepers@srhc.com

University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000

University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Wesley Medical Center
Wichita 4281730, Kansas 4273857 67214
Contact:
Site Public Contact
316-962-7802
WesleyResearch@wesleymc.com

Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925 40509
Contact:
Site Public Contact
720-874-1881
ResearchInstituteInquiries@CommonSpirit.org

The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925 40202
Contact:
Site Public Contact
502-562-3429

UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925 40245
Contact:
Site Public Contact
502-852-2755
ctoinfo@louisville.edu

Mary Bird Perkins Cancer Center
Baton Rouge 4315588, Louisiana 4331987 70809
Contact:
Site Public Contact
225-215-1353
clinicalresearch@marybird.com

Mary Bird Perkins Cancer Center - Metairie
Metairie 4333177, Louisiana 4331987 70002
Contact:
Site Public Contact
504-584-6990

MaineHealth Coastal Cancer Treatment Center
Bath 4957570, Maine 4971068 04530
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Penobscot Bay Medical Center
Rockport 4976817, Maine 4971068 04856
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Cancer Care Center of York County
Sanford 4977762, Maine 4971068 04073
Contact:
Site Public Contact
207-459-1600

MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Luminis Health Anne Arundel Medical Center
Annapolis 4347242, Maryland 4361885 21401
Contact:
Site Public Contact
443-481-1320
research@luminishealth.org

Maryland Proton Treatment Center
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
410-369-5226
info@mdproton.com

University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823

Veterans Administration Medical Center-Baltimore
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-463-6295

Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885 21287
Contact:
Site Public Contact
410-955-8804
jhcccro@jhmi.edu

UM Upper Chesapeake Medical Center
Bel Air 4348240, Maryland 4361885 21014
Contact:
Site Public Contact
443-643-3010

Suburban Hospital
Bethesda 4348599, Maryland 4361885 20814
Contact:
Site Public Contact
301-896-2719
bsquill1@jhmi.edu

University of Maryland Shore Medical Center at Easton
Easton 4353962, Maryland 4361885 21601
Contact:
Site Public Contact
410-822-1000
Christina.weisenborn@umm.edu

UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885 21061
Contact:
Site Public Contact
410-553-8100

UM Capital Region Medical Center
Largo 4360345, Maryland 4361885 20774
Contact:
Site Public Contact
301-755-4397
Sarah.Larson@umm.edu

Massachusetts General Hospital Cancer Center
Boston 4930956, Massachusetts 6254926 02114
Contact:
Site Public Contact
877-726-5130

Boston Medical Center
Boston 4930956, Massachusetts 6254926 02118
Contact:
Site Public Contact
617-638-8265

Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926 02215
Contact:
Site Public Contact
877-442-3324

Cape Cod Hospital
Hyannis 4940190, Massachusetts 6254926 02601
Contact:
Site Public Contact
508-862-5799

Dana-Farber/Brigham and Women's Cancer Center at Milford Regional
Milford 4943958, Massachusetts 6254926 01757
Contact:
Site Public Contact
877-332-4294

Dana-Farber/Brigham and Women's Cancer Center at South Shore
South Weymouth 4951568, Massachusetts 6254926 02190
Contact:
Site Public Contact
781-624-5000

Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
Contact:
Site Public Contact
800-865-1125
slusserb@med.umich.edu

McLaren Cancer Institute-Bay City
Bay City 4985180, Michigan 5001836 48706
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

University of Michigan - Brighton Center for Specialty Care
Brighton 4986994, Michigan 5001836 48116
Contact:
Site Public Contact
800-865-1125

Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 5001836 48183
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health Medical Center - Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

McLaren Cancer Institute-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Michigan Healthcare Professionals Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

Henry Ford Macomb Hospital-Clinton Township
Clinton Township 4989133, Michigan 5001836 48038
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Corewell Health Dearborn Hospital
Dearborn 4990510, Michigan 5001836 48124
Contact:
Site Public Contact
248-551-7695

Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836 48201
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Henry Ford Hospital
Detroit 4990729, Michigan 5001836 48202
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Michigan Healthcare Professionals Farmington
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

McLaren Cancer Institute-Flint
Flint 4992982, Michigan 5001836 48532
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Karmanos Cancer Institute at McLaren Greater Lansing
Lansing 4998830, Michigan 5001836 48910
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Contact:
Site Public Contact
517-364-3712
harsha.trivedi@umhsparrow.org

McLaren Cancer Institute-Lapeer Region
Lapeer 4998842, Michigan 5001836 48446
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Michigan Healthcare Professionals Macomb
Macomb 5000473, Michigan 5001836 48044
Contact:
Site Public Contact
rudi.ross@profoundresearch.io

Michigan Healthcare Professionals Madison Heights
Madison Heights 5000500, Michigan 5001836 48071
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

McLaren Cancer Institute-Macomb
Mount Clemens 5002656, Michigan 5001836 48043
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

McLaren Cancer Institute-Central Michigan
Mount Pleasant 5002714, Michigan 5001836 48858
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836 49120
Contact:
Site Public Contact
616-391-1230

Henry Ford Medical Center-Columbus
Novi 5004062, Michigan 5001836 48377
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

McLaren-Port Huron
Port Huron 5006233, Michigan 5001836 48060
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

MyMichigan Medical Center Saginaw
Saginaw 5007989, Michigan 5001836 48601
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph 5008327, Michigan 5001836 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695

Michigan Healthcare Professionals Troy
Troy 5012639, Michigan 5001836 48098
Contact:
Site Public Contact
rudi.ross@profoundresearch.io

Henry Ford West Bloomfield Hospital
West Bloomfield 7259621, Michigan 5001836 48322
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Mayo Clinic Health System in Albert Lea
Albert Lea 5016024, Minnesota 5037779 56007
Contact:
Site Public Contact
855-776-0015

Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Monticello Cancer Center
Monticello 5038045, Minnesota 5037779 55362
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296 39216
Contact:
Site Public Contact
601-815-6700

Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678 63376
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia 4381982, Missouri 4398678 65212
Contact:
Site Public Contact
573-882-7440

Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678 63141
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569

Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Contact:
Site Public Contact
417-347-4030
LJCrockett@freemanhealth.com

University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-7504
research@phelpshealth.org

Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520

Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678 63129
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569

Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678 63136
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066

Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569

BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Nebraska Medicine-Bellevue
Bellevue 5063805, Nebraska 5073708 68123
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

Nebraska Medicine-Village Pointe
Omaha 5074472, Nebraska 5073708 68118
Contact:
Site Public Contact
402-559-5600

University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

New Hampshire Oncology Hematology PA-Concord
Concord 5084868, New Hampshire 5090174 03301
Contact:
Site Public Contact
603-224-2556

Exeter Hospital
Exeter 5085966, New Hampshire 5090174 03833
Contact:
Site Public Contact
800-439-3837

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@dartmouth.edu

Solinsky Center for Cancer Care
Manchester 5089178, New Hampshire 5090174 03103
Contact:
Site Public Contact
800-339-6484

Clara Maass Medical Center
Belleville 5095549, New Jersey 5101760 07109
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760 08103
Contact:
Site Public Contact
856-325-6757

AtlantiCare Surgery Center
Egg Harbor 8766331, New Jersey 5101760 08234
Contact:
Site Public Contact
609-748-7200

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Elizabeth 5097598, New Jersey 5101760 07207
Contact:
Site Public Contact
908-994-8000

Englewood Hospital and Medical Center
Englewood 5097672, New Jersey 5101760 07631
Contact:
Site Public Contact
201-894-3456

The Cancer Institute of New Jersey Hamilton
Hamilton 5098765, New Jersey 5101760 08690
Contact:
Site Public Contact
609-631-6946

Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760 07302
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Contact:
Site Public Contact
973-322-2934
joanne.loeb@rwjbh.org

Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356

Rutgers New Jersey Medical School
Newark 5101798, New Jersey 5101760 07101
Contact:
Site Public Contact
732-235-7356

Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760 07112
Contact:
Site Public Contact
973-926-7230
Christine.Kosmides@rwjbh.org

The Valley Hospital - Luckow Pavilion
Paramus 5102387, New Jersey 5101760 07652
Contact:
Site Public Contact
201-634-5792
clinicaltrialsresearch@valleyhealth.com

Valley Health System Ridgewood Campus
Ridgewood 5103269, New Jersey 5101760 07450
Contact:
Site Public Contact
201-634-5792
clinicaltrialsresearch@valleyhealth.com

Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Contact:
Site Public Contact
908-685-2481
Siby.Varughese@rwjbh.org

Community Medical Center
Toms River 4504476, New Jersey 5101760 08755
Contact:
Site Public Contact
732-557-8294
Lennette.Gonzales@rwjbh.org

MD Anderson Cancer Center at Cooper-Voorhees
Voorhees Township 5105860, New Jersey 5101760 08043
Contact:
Site Public Contact
856-325-6757

Lovelace Medical Center-Saint Joseph Square
Albuquerque 5454711, New Mexico 5481136 87102
Contact:
Site Public Contact
505-272-0530
ZPollock@salud.unm.edu

University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Contact:
Site Public Contact
505-925-0348
HSC-ClinicalTrialInfo@salud.unm.edu

Presbyterian Kaseman Hospital
Albuquerque 5454711, New Mexico 5481136 87110
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Northwell Health Imbert Cancer Center
Bay Shore 5108169, New York 5128638 11706
Contact:
Site Public Contact
516-734-8896

New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn 5110302, New York 5128638 11215
Contact:
Site Public Contact
718-780-3677
Adg9003@nyp.org

Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Contact:
Site Public Contact
800-767-9355
askroswell@roswellpark.org

Mary Imogene Bassett Hospital
Cooperstown 5113664, New York 5128638 13326
Contact:
Site Public Contact
877-547-1750
CancerClinicalTrials@bassett.org

Noyes Memorial Hospital/Myers Cancer Center
Dansville 5114492, New York 5128638 14437
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

The New York Hospital Medical Center of Queens
Flushing 5117472, New York 5128638 11355
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Northwell Health Physicians Partners Radiation Medicine at Queens
Forest Hills 5117575, New York 5128638 11375
Contact:
Site Public Contact
718-520-6620

Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700

Northwell Health Cancer Institute at Huntington
Greenlawn 5119377, New York 5128638 11740
Contact:
Site Public Contact
516-734-8896

Northwell Health/Center for Advanced Medicine
Lake Success 5123853, New York 5128638 11042
Contact:
Site Public Contact
516-734-8896

Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638 10016
Contact:
Site Public Contact
CancerTrials@nyulangone.org

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
Contact:
Site Public Contact
212-342-5162
cancerclinicaltrials@cumc.columbia.edu

Manhattan Eye Ear and Throat Hospital
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-434-4460

NYP/Weill Cornell Medical Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-746-1848

Lenox Hill Hospital
New York 5128581, New York 5128638 10075
Contact:
Site Public Contact
516-734-8896

Queens Cancer Center
Rego Park 5133640, New York 5128638 11374
Contact:
Site Public Contact
718-312-3446

Highland Hospital
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Phelps Memorial Hospital Center
Sleepy Hollow 5138371, New York 5128638 10591
Contact:
Site Public Contact
914-366-1600

Staten Island University Hospital
Staten Island 5139568, New York 5128638 10305
Contact:
Site Public Contact
718-226-8888

Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215

State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476

Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Westchester Medical Center
Valhalla 5142090, New York 5128638 10595
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

Duke Cancer Center Cary
Cary 4459467, North Carolina 4482348 27518
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348 28203
Contact:
Site Public Contact
800-804-9376

Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348 28204
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Atrium Health Pineville/LCI-Pineville
Charlotte 4460243, North Carolina 4482348 28210
Contact:
Site Public Contact
980-442-2000

Atrium Health University City/LCI-University
Charlotte 4460243, North Carolina 4482348 28262
Contact:
Site Public Contact
800-804-9376

Levine Cancer Institute-Ballantyne
Charlotte 4460243, North Carolina 4482348 28277
Contact:
Site Public Contact
800-804-9376

Atrium Health Cabarrus/LCI-Concord
Concord 4461574, North Carolina 4482348 28025
Contact:
Site Public Contact
800-804-9376

Durham VA Medical Center
Durham 4464368, North Carolina 4482348 27705
Contact:
Site Public Contact
919-286-0411
VHADURcancertrials@va.gov

Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853

Novant Health Cancer Institute - Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Novant Health Presbyterian Medical Center Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Matthews Radiation Oncology Center
Matthews 4478334, North Carolina 4482348 28105
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Novant Health Cancer Institute - Matthews
Matthews 4478334, North Carolina 4482348 28105
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Atrium Health Union/LCI-Union
Monroe 4479946, North Carolina 4482348 28112
Contact:
Site Public Contact
980-442-2000

Novant Health Cancer Institute - Mooresville
Mooresville 4480125, North Carolina 4482348 28117
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

UNC Rex Healthcare
Raleigh 4487042, North Carolina 4482348 27607
Contact:
Site Public Contact
919-784-2500
CancCtrOncologyClinicalResearch@unchealth.unc.edu

Duke Cancer Center Raleigh
Raleigh 4487042, North Carolina 4482348 27609
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

UNC Rex Cancer Center of Wakefield
Raleigh 4487042, North Carolina 4482348 27614
Contact:
Site Public Contact
919-784-2500
CancCtrOncologyClinicalResearch@unchealth.unc.edu

Novant Cancer Institute Radiation Oncology - Supply
Supply 4830472, North Carolina 4482348 28462
Contact:
Site Public Contact
910-754-4716

Novant Health Cancer Institute Radiation Oncology - Wilmington
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-251-1839

Novant Health New Hanover Regional Medical Center
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-342-3000

Novant Health Forsyth Medical Center
Winston-Salem 4499612, North Carolina 4482348 27103
Contact:
Site Public Contact
336-718-8335
pjordan@novanthealth.org

Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348 27157
Contact:
Site Public Contact
336-713-6771

Altru Cancer Center
Grand Forks 5059429, North Dakota 5690763 58201
Contact:
Site Public Contact
701-780-6520

Summa Health System - Akron Campus
Akron 5145476, Ohio 5165418 44304
Contact:
Site Public Contact
330-375-4221
cancerresearch@summahealth.org

Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Summa Health System - Barberton Campus
Barberton 5146491, Ohio 5165418 44203
Contact:
Site Public Contact
330-375-4221
cancerresearch@summahealth.org

Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Contact:
Site Public Contact
330-363-7274
ClinicalReserachDept@aultman.com

Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418 45601
Contact:
Site Public Contact
877-779-7585
Jeffh@columbusccop.org

The Christ Hospital
Cincinnati 4508722, Ohio 5165418 45219
Contact:
Site Public Contact
513-585-0844

Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Summa Health Medina Medical Center
Medina 5162512, Ohio 5165418 44256
Contact:
Site Public Contact
330-375-4221
cancerresearch@summahealth.org

ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
Contact:
Site Public Contact
419-824-1842
PCIOncResearch@promedica.org

Cancer Centers of Southwest Oklahoma Research
Lawton 4540737, Oklahoma 4544379 73505
Contact:
Site Public Contact
877-231-4440

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
Contact:
Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org

Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150

Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742

Saint Luke's Cancer Center - Allentown
Allentown 5178127, Pennsylvania 6254927 18104
Contact:
Site Public Contact
610-776-4714

UPMC Altoona
Altoona 5178195, Pennsylvania 6254927 16601
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC-Heritage Valley Health System Beaver
Beaver 5179446, Pennsylvania 6254927 15009
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Saint Luke's University Hospital-Bethlehem Campus
Bethlehem 5180225, Pennsylvania 6254927 18015
Contact:
Site Public Contact
484-503-4151

Carlisle Regional Cancer Center
Carlisle 5183234, Pennsylvania 6254927 17015
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Chambersburg Hospital
Chambersburg 4557109, Pennsylvania 6254927 17201
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Saint Luke's Hospital-Anderson Campus
Easton 5188140, Pennsylvania 6254927 18045
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Ephrata Cancer Center
Ephrata 5188815, Pennsylvania 6254927 17522
Contact:
Site Public Contact
717-721-4840

UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927 16505
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Saint Vincent Hospital
Erie 5188843, Pennsylvania 6254927 16544
Contact:
Site Public Contact
814-452-5000

UPMC Cancer Center at UPMC Horizon
Farrell 5189377, Pennsylvania 6254927 16121
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Adams Cancer Center
Gettysburg 4558183, Pennsylvania 6254927 17325
Contact:
Site Public Contact
877-441-7957

UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg 5192029, Pennsylvania 6254927 15601
Contact:
Site Public Contact
724-838-1900

UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg 5192726, Pennsylvania 6254927 17109
Contact:
Site Public Contact
717-724-6765
klitchfield@PINNACLEHEALTH.org

Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Contact:
Site Public Contact
717-531-3779
CTO@hmc.psu.edu

IRMC Cancer Center
Indiana 5194868, Pennsylvania 6254927 15701
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown 5195561, Pennsylvania 6254927 15901
Contact:
Site Public Contact
814-534-4724

Sechler Family Cancer Center
Lebanon 5197517, Pennsylvania 6254927 17042
Contact:
Site Public Contact
717-741-8303
doxenberg@wellspan.org

Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927 17837
Contact:
Site Public Contact
570-374-8555
HemonCCTrials@geisinger.edu

UPMC Cancer Center at UPMC McKeesport
McKeesport 5200499, Pennsylvania 6254927 15132
Contact:
Site Public Contact
412-647-8073

Yolanda G Barco Oncology Institute
Meadville 5200644, Pennsylvania 6254927 16335
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-858-7746

UPMC Cancer Center - Monroeville
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Hillman Cancer Center in Coraopolis
Moon Township 5201821, Pennsylvania 6254927 15108
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Temple University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19140
Contact:
Site Public Contact
215-728-2983

Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000

UPMC-Magee Womens Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15213
Contact:
Site Public Contact
412-647-2811

UPMC-Saint Margaret
Pittsburgh 5206379, Pennsylvania 6254927 15215
Contact:
Site Public Contact
412-784-4900

West Penn Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15224
Contact:
Site Public Contact
412-578-5000

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073

UPMC-Shadyside Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-621-2334

UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454

UPMC-Saint Clair Hospital Cancer Center
Pittsburgh 5206379, Pennsylvania 6254927 15243
Contact:
Site Public Contact
412-502-3920

Geisinger Cancer Services-Pottsville
Pottsville 5207080, Pennsylvania 6254927 17901
Contact:
Site Public Contact
800-275-6401
HemonCCTrials@geisinger.edu

Saint Luke's Hospital - Upper Bucks Campus
Quakertown 5207381, Pennsylvania 6254927 18951
Contact:
Site Public Contact
610-776-4714

UPMC Cancer Center at UPMC Northwest
Seneca 5211432, Pennsylvania 6254927 16346
Contact:
Site Public Contact
814-676-7900

Saint Luke's Hospital - Monroe Campus
Stroudsburg 5214543, Pennsylvania 6254927 18360
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

UPMC Cancer Center-Uniontown
Uniontown 4561859, Pennsylvania 6254927 15401
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Uniontown Hospital Radiation Oncology
Uniontown 4561859, Pennsylvania 6254927 15401
Contact:
Site Public Contact
724-437-2503

UPMC Cancer Center-Washington
Washington 5218069, Pennsylvania 6254927 15301
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Washington Hospital Radiation Oncology
Washington 5218069, Pennsylvania 6254927 15301
Contact:
Site Public Contact
724-223-3788
cancer@washingtonhospital.org

Reading Hospital
West Reading 5218867, Pennsylvania 6254927 19611
Contact:
Site Public Contact
610-988-9323

Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
Contact:
Site Public Contact
Dawnmarie.DeFazio@ahn.org

Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Divine Providence Hospital
Williamsport 5219585, Pennsylvania 6254927 17754
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

WellSpan Health-York Cancer Center
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957

UPMC Memorial
York 4562407, Pennsylvania 6254927 17408
Contact:
Site Public Contact
717-724-6760

Rhode Island Hospital
Providence 5224151, Rhode Island 5224323 02903
Contact:
Site Public Contact
401-444-1488

Smilow Cancer Hospital Care Center - Westerly
Westerly 5225631, Rhode Island 5224323 02891
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Saint Joseph's/Candler - Bluffton Campus
Bluffton 4571722, South Carolina 4597040 29910
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Saint Francis Hospital
Greenville 4580543, South Carolina 4597040 29601
Contact:
Site Public Contact
864-603-6234
Heather_Rich@bshsi.org

Saint Francis Cancer Center
Greenville 4580543, South Carolina 4597040 29607
Contact:
Site Public Contact
864-603-6234
Heather_Rich@bshsi.org

Self Regional Healthcare
Greenwood 4580569, South Carolina 4597040 29646
Contact:
Site Public Contact
864-725-4771
nmcgaha@selfregional.org

Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island 4581832, South Carolina 4597040 29926
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Beaufort Memorial/New River Cancer Center
Okatie 4589956, South Carolina 4597040 29909
Contact:
Site Public Contact
843-273-7980

Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Houston Methodist San Jacinto Hospital
Baytown 4672731, Texas 4736286 77521
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

MD Anderson in The Woodlands
Conroe 4682991, Texas 4736286 77384
Contact:
Site Public Contact
866-632-6789
askmdanderson@mdanderson.org

Houston Methodist Hospital
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-790-2700

M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Methodist Willowbrook Hospital
Houston 4699066, Texas 4736286 77070
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

MD Anderson West Houston
Houston 4699066, Texas 4736286 77079
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Houston Methodist West Hospital
Houston 4699066, Texas 4736286 77094
Contact:
Site Public Contact
832-522-2873

MD Anderson League City
League City 4705692, Texas 4736286 77573
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Houston Methodist Saint John Hospital
Nassau Bay 4713813, Texas 4736286 77058
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

MD Anderson in Sugar Land
Sugar Land 4734825, Texas 4736286 77478
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Houston Methodist Sugar Land Hospital
Sugar Land 4734825, Texas 4736286 77479
Contact:
Site Public Contact
281-242-2873

Houston Methodist The Woodlands Hospital
The Woodlands 4736476, Texas 4736286 77385
Contact:
Site Public Contact
713-790-2700
hmthewoodlands@houstonmethodist.org

American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork 5844096, Utah 5549030 84003
Contact:
Site Public Contact
801-855-4100
officeofresearch@imail.org

Farmington Health Center
Farmington 5774662, Utah 5549030 84025
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Logan Regional Hospital
Logan 5777544, Utah 5549030 84321
Contact:
Site Public Contact
435-716-6400
officeofresearch@imail.org

Intermountain Medical Center
Murray 5778755, Utah 5549030 84107
Contact:
Site Public Contact
801-507-3950
officeofresearch@imail.org

McKay-Dee Hospital Center
Ogden 5779206, Utah 5549030 84403
Contact:
Site Public Contact
801-387-7426
officeofresearch@imail.org

Utah Valley Regional Medical Center
Provo 5780026, Utah 5549030 84604
Contact:
Site Public Contact
801-357-7965
officeofresearch@imail.org

Riverton Hospital
Riverton 5780557, Utah 5549030 84065
Contact:
Site Public Contact
801-507-3950
officeofresearch@imail.org

University of Utah Sugarhouse Health Center
Salt Lake City 5780993, Utah 5549030 84106
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Utah Cancer Specialists-Salt Lake City
Salt Lake City 5780993, Utah 5549030 84106
Contact:
Site Public Contact
801-933-6070
officeofresearch@imail.org

Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

LDS Hospital
Salt Lake City 5780993, Utah 5549030 84143
Contact:
Site Public Contact
801-408-1347
officeofresearch@imail.org

Saint George Regional Medical Center
St. George 5546220, Utah 5549030 84770
Contact:
Site Public Contact
833-321-3332
officeofresearch@imail.org

Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners 5233780, Vermont 5242283 05602
Contact:
Site Public Contact
802-225-5400

University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Contact:
Site Public Contact
802-656-4101
rpo@uvm.edu

Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@hitchcock.org

Inova Alexandria Hospital
Alexandria 4744091, Virginia 6254928 22304
Contact:
Site Public Contact
703-776-2580
Stephanie.VanBebber@inova.org

Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Inova Fair Oaks Hospital
Fairfax 4758023, Virginia 6254928 22033
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Bon Secours Saint Francis Medical Center
Midlothian 4772943, Virginia 6254928 23114
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Cancer Institute at Reynolds Crossing
Richmond 4781708, Virginia 6254928 23230
Contact:
Site Public Contact
804-893-8978
Anne_caramella@bshsi.org

Virginia Commonwealth University/Massey Cancer Center
Richmond 4781708, Virginia 6254928 23298
Contact:
Site Public Contact
CTOclinops@vcu.edu

Virginia Mason Medical Center
Seattle 5809844, Washington 5815135 98101
Contact:
Site Public Contact
206-287-6275
cancerresearch@virginiamason.org

Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Contact:
Site Public Contact
oncologyresearch@lhs.org

Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150

Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Contact:
Site Public Contact
509-897-5993
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West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
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304-293-7374
cancertrialsinfo@hsc.wvu.edu

Wheeling Hospital/Schiffler Cancer Center
Wheeling 5280854, West Virginia 4826850 26003
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304-243-6442

Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
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715-623-9869
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ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468 54911
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920-364-3604
ResearchDept@thedacare.org

Ascension Saint Elizabeth Hospital
Appleton 5244080, Wisconsin 5279468 54915
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AWRI.inquiry@ascension.org

Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468 54806
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218-786-3308
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Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield 5246835, Wisconsin 5279468 53045
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Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
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414-302-2304
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Ascension Calumet Hospital
Chilton 5248469, Wisconsin 5279468 53014
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Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
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800-782-8581
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Ascension Saint Francis - Reiman Cancer Center
Franklin 5253710, Wisconsin 5279468 53132
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Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
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414-302-2304
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Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
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414-302-2304
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Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
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920-433-8889
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Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
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920-433-8889
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Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
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414-302-2304
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University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
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800-622-8922
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Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
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Mayo Clinic Health System-Franciscan Healthcare
La Crosse 5258957, Wisconsin 5279468 54601
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855-776-0015

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
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800-622-8922
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University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
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Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
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Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
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Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
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262-257-5100

Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon 5262649, Wisconsin 5279468 53097
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Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
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Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53211
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Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
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Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
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414-805-3666

Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
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Zablocki Veterans Administration Medical Center
Milwaukee 5263045, Wisconsin 5279468 53295
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888-469-6614

Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
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Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
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414-805-0505

Ascension Mercy Hospital
Oshkosh 5265838, Wisconsin 5279468 54904
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AWRI.inquiry@ascension.org

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
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414-302-2304
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Ascension All Saints Hospital
Racine 5268249, Wisconsin 5279468 53405
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Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
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Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
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715-847-2353
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Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
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Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
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Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
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Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
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715-847-2353
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Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
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800-782-8581
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Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
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920-433-8889
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Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
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414-302-2304
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Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
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414-302-2304
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Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
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877-405-6866

Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa 5278159, Wisconsin 5279468 53226
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AWRI.Inquiry@Ascension.org

Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
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414-302-2304
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Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
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414-302-2304
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Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
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414-805-0505

Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
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800-782-8581
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Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
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715-422-7718

More Details

NCT ID
NCT04513717
Status
Recruiting
Sponsor
NRG Oncology

Detailed Description

PRIMARY OBJECTIVES: I. To determine whether men with National Comprehensive Cancer Network (NCCN) high risk prostate cancer who are in the lower 2/3 of Decipher genomic risk (=< 0.85) can be treated with 12 months androgen deprivation therapy (ADT) plus radiation therapy (RT) instead of 24 months ADT+RT and experience non-inferior metastasis-free survival. (De-intensification study) II. To determine whether men with NCCN high risk prostate cancer who are in the upper 1/3 of Decipher genomic risk (> 0.85) or have node-positive disease by conventional imaging (magnetic resonance imaging [MRI] or computed tomography [CT] scan) will have a superior metastasis-free survival (MFS) through treatment intensification with apalutamide added to the standard of RT plus 24 month ADT. (Intensification study) SECONDARY OBJECTIVES: I. To compare overall survival (OS) between the standard of care (RT plus 24 months of ADT) and either the de-intensification (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) II. To compare time to prostate specific antigen (PSA) failure or start of salvage treatment between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) III. To compare PSA failure-free survival with non-castrate testosterone and no additional therapies between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) IV. To compare MFS judged based on either standard or molecular imaging between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) V. To compare prostate cancer-specific mortality between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) VI. To compare testosterone levels at the time of PSA failure and metastases between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) VII. To compare time to testosterone recovery (defined as a T > 200) between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) VIII. To compare adverse events, both clinician-reported using Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0 and patient-reported using Patient Reported Outcome (PRO)-CTCAE items, between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) EXPLORATORY OBJECTIVES: I. To compare changes in cardio-metabolic markers, including body mass index, and waist circumference, between the standard of care (RT plus 24 months of ADT) and either the de-intensification arm (RT plus 12 months of ADT) or intensification arm (RT plus 24 months of ADT plus apalutamide). (De-intensification and intensification studies) II. To develop a machine learning/artificial intelligence algorithm for radiotherapy quality assurance. (De-intensification and Intensification studies) III. To perform future translational correlative studies using biological and imaging data. (De-intensification and intensification studies) IV. Impact of position emission tomography (PET) use, measured by the proportion of times each type of imaging was used, in high-risk prostate cancer. (De-intensification and intensification studies) PATIENT-REPORTED OUTCOMES OBJECTIVES: PRIMARY OBJECTIVES: I. To compare sexual and hormonal function related quality of life, as measured by the Expanded Prostate Cancer Index Composite-26 (EPIC), between the standard of care (RT plus 24 months of ADT) and the de-intensification arm (RT plus 12 months of ADT). (De-Intensification Study) II. To compare fatigue, as measured by the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue instrument, between the standard of care (RT plus 24 months of ADT) and the intensification arm (RT plus 24 months of ADT plus apalutamide). (Intensification Study) SECONDARY OBJECTIVES: I. To compare depression, as measured by the PROMIS-depression, between the standard of care (RT plus 24 months of ADT) and the de-intensification arm (RT plus 12 months of ADT). (De-Intensification Study) II. To compare depression, as measured by the PROMIS-depression, between the standard of care (RT plus 24 months of ADT) and the intensification arm (RT plus 24 months of ADT plus apalutamide). (Intensification Study) EXPLORATORY OBJECTIVES: I. To compare cognition, as measured by the Functional Assessment of Chronic Illness Therapy-Cognitive (FACT-Cog) perceived cognitive abilities subscale, between the standard of care (RT plus 24 months of ADT) and the de-intensification arm (RT plus 12 months of ADT). (De-Intensification Study) II. To compare bowel and urinary function related quality of life, as measured by the Expanded Prostate Cancer Index Composite-26 (EPIC), between the standard of care (RT plus 24 months of ADT) and the de-intensification arm (RT plus 12 months of ADT). (De-Intensification Study) III. To compare fatigue, as measured by the PROMIS-Fatigue instrument, between the standard of care (RT plus 24 months of ADT) and the de-intensification arm (RT plus 12 months of ADT). (De-Intensification Study) IV. To compare sexual and hormonal function related quality of life, as measured by the Expanded Prostate Cancer Index Composite-26 (EPIC), between the standard of care (RT plus 24 months of ADT) and the intensification arm (RT plus 24 months of ADT plus apalutamide). (Intensification Study) V. To compare bowel and urinary function related quality of life, as measured by the Expanded Prostate Cancer Index Composite-26 (EPIC), between the standard of care (RT plus 24 months of ADT) and the intensification arm (RT plus 24 months of ADT plus apalutamide). (Intensification Study) VI. To compare cognition, as measured by the Functional Assessment of Chronic Illness Therapy-Cognitive (FACT-Cog) perceived cognitive abilities subscale, between the standard of care (RT plus 24 months of ADT) and the intensification arm (RT plus 24 months of ADT plus apalutamide). (Intensification Study) OUTLINE: Patients are randomized to 1 of 4 arms. DE-INTENSIFICATION STUDY (DECIPHER SCORE =< 0.85): ARM I: Patients undergo radiation therapy (RT) over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 24 months in the absence of disease progression or unacceptable toxicity. ARM II: Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 12 months in the absence of disease progression or unacceptable toxicity. INTENSIFICATION STUDY (DECIPHER SCORE > 0.85 OR NODE POSITIVE): ARM III: Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix and bicalutamide or flutamide) for 24 months in the absence of disease progression or unacceptable toxicity. ARM IV: Patients undergo RT over 2-11 weeks and receive ADT (consisting of either leuprolide, goserelin, triptorelin, degarelix, buserelin, histrelin, or relugolix) for 24 months in the absence of disease progression or unacceptable toxicity. Patients also receive apalutamide orally (PO) once daily (QD). Treatment repeats every 90 days for up to 8 cycles (24 months) in the absence of disease progression or unacceptable toxicity. Patients undergo bone scan, positron emission tomography (PET) scan, computed tomography (CT) scan, and magnetic resonance imaging (MRI) at screening and as clinically indicated and may optionally undergo blood sample collection throughout the study.