Two Studies for Patients With Unfavorable Intermediate Risk Prostate Cancer Testing Less Intense Treatment for Patients With a Low Gene Risk Score and Testing a More Intense Treatment for Patients With a Higher Gene Risk Score, The Guidance Trial

Purpose

This phase III trial uses the Decipher risk score to guide therapy selection. Decipher score is based on the activity of 22 genes in prostate tumor and may predict how likely it is for recurrent prostate cancer to spread (metastasize) to other parts of the body. Decipher score in this study is used for patient selection and the two variations of treatment to be studied: intensification for higher Decipher score or de-intensification for low Decipher score. Patients with higher Decipher risk score will be assigned to the part of the study that compares the use of 6 months of the usual treatment (hormone therapy and radiation treatment) to the use of darolutamide plus the usual treatment (intensification). The purpose of this section of the study is to determine whether the additional drug can reduce the chance of cancer coming back and spreading in patients with higher Decipher score. The addition of darolutamide to the usual treatment may better control the cancer and prevent it from spreading. Alternatively, patients with low Decipher risk score will be assigned to the part of the study that compares the use of radiation treatment alone (de-intensification) to the usual approach (6 months of hormone therapy plus radiation). The purpose of this part of the study is to determine if radiation treatment alone is as effective compared to the usual treatment without affecting the chance of tumor coming back in patients with low Decipher score prostate cancer. Radiation therapy uses high energy to kill tumor cells and reduce the tumor size. Hormone therapy drugs such as darolutamide suppress or block the production or action of male hormones that play role in prostate cancer development. Effect of radiation treatment alone in patients with low Decipher score prostate cancer could be the same as the usual approach in stabilizing prostate cancer and preventing it from spreading, while avoiding the side effects associated with hormonal therapy.

Condition

  • Prostate Adenocarcinoma

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
Male
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Pathologically (histologically or cytologically) proven diagnosis of adenocarcinoma of the prostate within 270 days prior to registration - Unfavorable intermediate risk prostate cancer, defined as having ALL the following bulleted criteria: - Has at least one intermediate risk factor (IRF): - PSA 10-20 ng/mL - Clinical stage T2b-c (digital rectal examination [DRE] and/or imaging) by American Joint Committee on Cancer (AJCC) 8th edition - Gleason score 7 (Gleason 3+4 or 4+3 [ International Society of Urological Pathology (ISUP) Grade Group 2-3]) - Has ONE or more of the following 'unfavorable' intermediate-risk designators: - > 1 immature reticulocyte fraction (IRF) - Gleason 4+3=7 (ISUP Grade Group 3) - >= 50% of biopsy cores positive - Biopsies may include 'sextant' sampling of right/left regions of the prostate, often labeled base, mid-gland and apex. All such 'sextant' biopsy cores should be counted. Men may also undergo 'targeted' sampling of prostate lesions (guided by MRI, ultrasound or other approaches). A targeted lesion that is biopsied more than once and demonstrates cancer (regardless of number of targeted cores involved) should count as a single additional positive core sampled and positive. In cases of uncertainty, count the biopsy sampling as sextant core(s) - Absence of high-risk features - Appropriate stage for study entry based on the following diagnostic workup: - History/physical examination within 120 days prior to registration; - Negative bone imaging (M0) within 120 days prior to registration; Note: Tc-99m bone scan or sodium fluoride (NaF) positron emission tomography (PET) are allowed. Equivocal bone scan findings are allowed if plain films X-ray, computed tomography (CT) or magnetic resonance imaging (MRI) are negative for metastasis at the concerned site(s). While a negative fluciclovine, choline, or prostate specific membrane antigen (PSMA) PET may be counted as acceptable substitute for bone imaging, any suspicious findings must be confirmed and correlated with conventional imaging (Tc-99m bone scan, NaF PET, CT, X-ray, or MRI) to determine eligibility based on the latter modalities (e.g. M0 based on conventional imaging modalities) - Clinically negative lymph nodes (N0) as established by conventional imaging (pelvic +/- abdominal CT or MR), within 120 days prior to registration. Patients with lymph nodes equivocal or questionable by imaging are eligible if the nodes are =< 1.0 cm in short axis and/or if biopsy is negative. Note: While a negative fluciclovine, choline, or prostate specific membrane antigen (PSMA) PET may be counted as acceptable substitute for pelvic imaging, any suspicious findings must be confirmed by conventional imaging (CT, MRI or biopsy). If the findings do not meet pathological criteria based on the latter modalities (e.g. node =< 10 mm in short axis, negative biopsy), the patient will still be eligible - Age >= 18 - Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 120 days prior to registration - Non-castrate testosterone level (> 50 ng/dL) within 120 days prior to registration - Absolute neutrophil >= 1,000 cells/mm^3 (within 120 days prior to registration) - Hemoglobin >= 8.0 g/dL, independent of transfusion and/or growth factors (within 120 days prior to registration) - Platelet count >= 100,000 cells/mm^3 independent of transfusion and/or growth factors (within 120 days prior to registration) - Creatinine clearance (CrCl) >= 30 mL/min estimated by Cockcroft-Gault equation (within 120 days prior to registration) - For African American patients specifically whose renal function is not considered adequate by the formula above, an alternative formula that takes race into account (Chronic Kidney Disease Epidemiology Collaboration CKD-EPI formula) should be used for calculating the related estimated glomerular filtration rate (GFR) with a correction factor for African American race creatinine clearance for trial eligibility, where GFR >= 30 mL/min/1.73m^2 will be considered adequate - Total bilirubin: 1.5 =< institutional upper limit of normal (ULN) (within 120 days prior to registration) (Note: In subjects with Gilbert's syndrome, if total bilirubin is > 1.5 x ULN, measure direct and indirect bilirubin. If direct bilirubin is less than or equal to 1.5 x ULN, subject is eligible) - Aspartate aminotransferase (AST)(serum glutamic-oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT)(serum glutamate pyruvate transaminase [SGPT]): =< 2.5 x institutional ULN (within 120 days prior to registration) - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial; Note: HIV testing is not required for eligibility for this protocol - For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated. - Note: Known positive test for hepatitis B virus surface antigen (HBV sAg) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy. Patients who are immune to hepatitis B (anti-Hepatitis B surface antibody positive) are eligible (e.g. patients immunized against hepatitis B) - For patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load - Note: Known positive test for hepatitis C virus ribonucleic acid (HCV RNA) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

Exclusion Criteria

  • Previous radical surgery (prostatectomy) or any form of curative-intent ablation whether focal or whole-gland (e.g., cryosurgery, high intensity focused ultrasound [HIFU], laser thermal ablation, etc.) for prostate cancer - Definitive clinical or radiologic evidence of metastatic disease (M1) - Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years. History of or current diagnosis of hematologic malignancy is not allowed - Prior radiotherapy to the prostate/pelvis region that would result in overlap of radiation therapy fields - Previous bilateral orchiectomy - Previous hormonal therapy, such as luteinizing hormone-releasing hormone (LHRH) agonists (e.g., leuprolide, goserelin, buserelin, triptorelin) or LHRH antagonist (e.g. degarelix), anti-androgens (e.g., flutamide, bicalutamide, cyproterone acetate). ADT started prior to study registration is not allowed - Prior use of 5-alpha-reductase inhibitors is allowed, however, it must be stopped prior to enrollment on the study with at least a 30 day washout period before baseline study PSA measure and registration - Active testosterone replacement therapy; any replacement therapy must be stopped at least 30 days prior to registration - Severe, active co-morbidity defined as follows: - Current severe or unstable angina; - New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification) - History of any condition that in the opinion of the investigator, would preclude participation in this study - Inability to swallow oral pills - High risk features, which includes any of the following: - Gleason 8-10 [ISUP Grade Group 4-5] - PSA > 20 - cT3-4 by digital exam OR gross extra-prostatic extension on imaging [indeterminate MRI evidence will not count and the patient will be eligible]

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm I (RT) 		Patients undergo radiation therapy (RT) using a recognized regimen (2-3 days a week or 5 days a week for 2-11 weeks) in the absence of disease progression or unacceptable toxicity.
  • Radiation: Radiation Therapy
    Undergo RT
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
Experimental
Arm II (RT, ADT) 		Patients undergo RT as Arm I. Patients also receive androgen deprivation therapy (ADT) consisting of leuprolide, goserelin, buserelin, histrelin, triptorelin, degarelix, or relugolix at the discretion of the treating physician, for 6 months in the absence of disease progression or unacceptable toxicity. Patients may also receive bicalutamide or flutamide for 0, 30 or 180 days.
  • Drug: Bicalutamide
    Drug
    Other names:
    • Casodex
    • Cassotide
    • Cosudex
    • ICI 176,334
    • ICI 176334
    • Utamide
  • Drug: Buserelin
    Drug
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Drug: Degarelix
    Drug
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Flutamide
    Drug
    Other names:
    • 4'-Nitro-3'-trifluoromethylisobutyranilide
    • Apimid
    • Cebatrol
    • Chimax
    • Cytomid
    • Drogenil
    • Euflex
    • Eulexine
    • Flucinom
    • Flucinome
    • Flugerel
    • Fluken
    • Flulem
    • FLUT
    • Fluta-Gry
    • Flutabene
    • Flutacan
    • Flutamex
    • Flutamin
    • Flutan
    • Flutaplex
    • Fugerel
    • Grisetin
    • Niftolide
    • Oncosal
    • Profamid
    • Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
    • Prostacur
    • Prostadirex
    • Prostica
    • Prostogenat
    • Sch 13521
    • Tafenil
    • Tecnoflut
    • Testotard
  • Drug: Goserelin
    Drug
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Drug
  • Drug: Leuprolide
    Drug
    Other names:
    • Leuprorelin
  • Radiation: Radiation Therapy
    Undergo RT
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Drug
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Drug
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline
Experimental
Arm III (RT, ADT) 		Patients receive treatment as in Arm II.
  • Drug: Bicalutamide
    Drug
    Other names:
    • Casodex
    • Cassotide
    • Cosudex
    • ICI 176,334
    • ICI 176334
    • Utamide
  • Drug: Buserelin
    Drug
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Drug: Degarelix
    Drug
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Flutamide
    Drug
    Other names:
    • 4'-Nitro-3'-trifluoromethylisobutyranilide
    • Apimid
    • Cebatrol
    • Chimax
    • Cytomid
    • Drogenil
    • Euflex
    • Eulexine
    • Flucinom
    • Flucinome
    • Flugerel
    • Fluken
    • Flulem
    • FLUT
    • Fluta-Gry
    • Flutabene
    • Flutacan
    • Flutamex
    • Flutamin
    • Flutan
    • Flutaplex
    • Fugerel
    • Grisetin
    • Niftolide
    • Oncosal
    • Profamid
    • Propanamide, 2-Methyl-N-(4-nitro-3-(trifluoromethyl)phenyl)-
    • Prostacur
    • Prostadirex
    • Prostica
    • Prostogenat
    • Sch 13521
    • Tafenil
    • Tecnoflut
    • Testotard
  • Drug: Goserelin
    Drug
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Drug
  • Drug: Leuprolide
    Drug
    Other names:
    • Leuprorelin
  • Radiation: Radiation Therapy
    Undergo RT
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Drug
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Drug
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline
Experimental
Arm IV (RT, ADT, darolutamide) 		Patients receive RT and ADT as in Arm II. Patients also receive darolutamide PO BID on days 1-90. Treatment repeats every 90 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity.
  • Drug: Buserelin
    Drug
    Other names:
    • 6-[O-(1,1-Dimethylethyl)-D-serine]-9-(N-ethyl-L-prolinamide)-10-deglycinamide-luteinizing Hormone-releasing Factor (Pig)
    • BSRL
    • Busereline
    • Etilamide
    • HOE 766
    • HOE-766
    • HOE766
    • ICI 123215
    • ICI-123215
    • ICI123215
    • S74 6766
    • S74-6766
    • S746766
    • Tiloryth
  • Drug: Darolutamide
    Given PO
    Other names:
    • Antiandrogen ODM-201
    • BAY 1841788
    • BAY-1841788
    • BAY1841788
    • Nubeqa
    • ODM 201
    • ODM-201
    • ODM201
  • Drug: Degarelix
    Drug
    Other names:
    • ASP 3550
    • ASP-3550
    • ASP3550
    • FE 200486
    • FE-200486
    • FE200486
    • Firmagon
  • Drug: Goserelin
    Drug
    Other names:
    • ICI-118630
  • Drug: Histrelin
    Drug
  • Drug: Leuprolide
    Drug
    Other names:
    • Leuprorelin
  • Radiation: Radiation Therapy
    Undergo RT
    Other names:
    • Cancer Radiotherapy
    • Energy Type
    • ENERGY_TYPE
    • Irradiate
    • Irradiated
    • Irradiation
    • Radiation
    • Radiation Therapy, NOS
    • Radiotherapeutics
    • Radiotherapy
    • RT
    • Therapy, Radiation
  • Drug: Relugolix
    Drug
    Other names:
    • N-(4-(1-((2,6-Difluorophenyl)methyl)-5-((dimethylamino)methyl)-1,2,3,4-tetrahydro-3-(6-methoxy-3-pyridazinyl)-2,4-dioxothieno(2,3-d)pyrimidin-6-yl)phenyl)-N'-methoxyurea
    • Orgovyx
    • Relumina
    • TAK 385
    • TAK-385
    • TAK385
  • Drug: Triptorelin
    Drug
    Other names:
    • 6-D-Tryptophan-LH-RH
    • 6-D-Tryptophanluteinizing Hormone-releasing Factor
    • AY 25650
    • AY-25650
    • AY25650
    • CL 118532
    • CL-118,532
    • CL-118532
    • CL118532
    • Detryptoreline

Recruiting Locations

University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764 35233
Contact:
Site Public Contact
205-934-0220
tmyrick@uab.edu

Arizona Center for Cancer Care - Gilbert
Gilbert 5295903, Arizona 5551752 85297
Contact:
Site Public Contact
480-278-8261
penny.labriola@arizonaccc.com

Arizona Center for Cancer Care-Peoria
Peoria 5308480, Arizona 5551752 85381
Contact:
Site Public Contact
623-773-2873

Arizona Center for Cancer Care - Phoenix
Phoenix 5308655, Arizona 5551752 85027
Contact:
Site Public Contact
480-278-8261
penny.labriola@arizonaccc.com

Arizona Center for Cancer Care-Surprise
Surprise 5316428, Arizona 5551752 85374
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274

Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn 5325223, California 5332921 95603
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

AIS Cancer Center at San Joaquin Community Hospital
Bakersfield 5325738, California 5332921 93301
Contact:
Site Public Contact
661-323-4673

Tower Cancer Research Foundation
Beverly Hills 5328041, California 5332921 90211
Contact:
Site Public Contact
towercancerresearch@toweroncology.com

Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park 5333282, California 5332921 95682
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

City of Hope Corona
Corona 5339631, California 5332921 92882
Contact:
Site Public Contact
626-256-4673
becomingapatient@coh.org

City of Hope Comprehensive Cancer Center
Duarte 5344147, California 5332921 91010
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691

UC San Diego Health System - Encinitas
Encinitas 5346646, California 5332921 92024
Contact:
Site Public Contact
760-536-7700

Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Washington Hospital
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
510-745-6433

Kaiser Permanente-Fresno
Fresno 5350937, California 5332921 93720
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Marin General Hospital
Greenbrae 5354013, California 5332921 94904
Contact:
Site Public Contact
415-925-7325

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921 92612
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

City of Hope at Irvine Lennar
Irvine 5359777, California 5332921 92618
Contact:
Site Public Contact
877-467-3411

UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
Contact:
Site Public Contact
858-822-5354
cancercto@ucsd.edu

City of Hope Antelope Valley
Lancaster 5364940, California 5332921 93534
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Los Angeles General Medical Center
Los Angeles 5368361, California 5332921 90033
Contact:
Site Public Contact
323-865-0451
uscnorrisinfo@med.usc.edu

USC / Norris Comprehensive Cancer Center
Los Angeles 5368361, California 5332921 90033
Contact:
Site Public Contact
323-865-0451

Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965

Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400

Memorial Medical Center
Modesto 5373900, California 5332921 95355
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Providence Queen of The Valley
Napa 5376095, California 5332921 94558
Contact:
Site Public Contact
707-521-3830

Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Saint Joseph Hospital - Orange
Orange 5379513, California 5332921 92868
Contact:
Site Public Contact
714-734-6220

UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921 92868
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Contact:
Site Public Contact
877-642-4691
kpoct@kp.org

Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089

Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

California Protons Cancer Therapy Center
San Diego 5391811, California 5332921 92121
Contact:
Site Public Contact
858-299-5982

Sharp Memorial Hospital
San Diego 5391811, California 5332921 92123
Contact:
Site Public Contact
858-939-5062
cathy.wood@sharp.com

Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921 94158
Contact:
Site Public Contact
877-827-3222
cancertrials@ucsf.edu

Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Ridley-Tree Cancer Center
Santa Barbara 5392952, California 5332921 93105
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

City of Hope South Pasadena
South Pasadena 5397717, California 5332921 91030
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Cedars-Sinai Cancer - Tarzana
Tarzana 5401143, California 5332921 91356
Contact:
Site Public Contact
818-981-3818

City of Hope South Bay
Torrance 5403022, California 5332921 90503
Contact:
Site Public Contact
877-467-3411

Torrance Memorial Physician Network - Cancer Care
Torrance 5403022, California 5332921 90505
Contact:
Site Public Contact
310-750-3300
courtney.steeneken@tmphysicians.com

Torrance Memorial Medical Center
Torrance 5403022, California 5332921 90509
Contact:
Site Public Contact
310-517-4665

Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee 5403676, California 5332921 96161
Contact:
Site Public Contact
530-582-6450

City of Hope Upland
Upland 5404915, California 5332921 91786
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Sutter Solano Medical Center/Cancer Center
Vallejo 5405380, California 5332921 94589
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

BASS Medical Group - Lennon
Walnut Creek 5406990, California 5332921 94598
Contact:
Site Public Contact
307-760-7636
brenna.lindsey@bassmedicalgroup.com

UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
720-848-0650

Rocky Mountain Cancer Centers-Boulder
Boulder 5574991, Colorado 5417618 80304
Contact:
Site Public Contact
303-777-2663
info@westernstatesncorp.org

UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
Contact:
Site Public Contact
719-365-2406

Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
Contact:
Site Public Contact
719-364-6700

Shaw Cancer Center
Edwards 5420885, Colorado 5417618 81632
Contact:
Site Public Contact
970-569-7429

Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150

Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Banner North Colorado Medical Center
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
970-810-3046
BMDACCResearchCOMailbox@bannerhealth.com

UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UCHealth Highlands Ranch Hospital
Highlands Ranch 5425043, Colorado 5417618 80129
Contact:
Site Public Contact
720-848-0650

Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083

Banner McKee Medical Center
Loveland 5579368, Colorado 5417618 80539
Contact:
Site Public Contact
970-810-3046
BMDACCResearchCOMailbox@bannerhealth.com

Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport 5282804, Connecticut 4831725 06606
Contact:
Site Public Contact
860-972-4700

Smilow Cancer Hospital Care Center at Greenwich
Greenwich 4835395, Connecticut 4831725 06830
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center - Guilford
Guilford 4835512, Connecticut 4831725 06437
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Hartford Hospital
Hartford 4835797, Connecticut 4831725 06102
Contact:
Site Public Contact
860-545-5363

Midstate Medical Center
Meriden 4838524, Connecticut 4831725 06451
Contact:
Site Public Contact
866-662-5678

The Hospital of Central Connecticut
New Britain 4839292, Connecticut 4831725 06050
Contact:
Site Public Contact
860-224-5660

Yale University
New Haven 4839366, Connecticut 4831725 06520
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Norwalk Hospital
Norwalk 4839822, Connecticut 4831725 06856
Contact:
Site Public Contact
203-852-2996
jennifer.long@norwalkhealth.org

Smilow Cancer Hospital Care Center-Trumbull
Trumbull 4844459, Connecticut 4831725 06611
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center - Waterford
Waterford 8480031, Connecticut 4831725 06385
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Beebe South Coastal Health Campus
Millville 4143696, Delaware 4142224 19967
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

George Washington University Medical Center
Washington D.C. 4140963, District of Columbia 4138106 20037
Contact:
Site Public Contact
202-741-2210

Bay Pines VA Healthcare System
Bay Pines 4146855, Florida 4155751 33744
Contact:
Site Public Contact
727-398-6661
vhabayresearch@va.gov

Boca Raton Regional Hospital
Boca Raton 4148411, Florida 4155751 33486
Contact:
Site Public Contact
561-955-4800

University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751 32610
Contact:
Site Public Contact
352-273-8010
cancer-center@ufl.edu

Jupiter Medical Center
Jupiter 4160610, Florida 4155751 33458
Contact:
Site Public Contact
561-745-5768

Cleveland Clinic-Weston
Weston 4178003, Florida 4155751 33331
Contact:
Site Public Contact
954-659-5705
CancerAnswer@ccf.org

Grady Health System
Atlanta 4180439, Georgia 4197000 30303
Contact:
Site Public Contact
404-778-1868

Emory Proton Therapy Center
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
404-251-2854
allyson.anderson@emory.edu

Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
888-946-7447

Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000 30322
Contact:
Site Public Contact
404-778-1868

Emory Saint Joseph's Hospital
Atlanta 4180439, Georgia 4197000 30342
Contact:
Site Public Contact
404-851-7115

Emory Decatur Hospital
Decatur 4191124, Georgia 4197000 30033
Contact:
Site Public Contact
440-778-1868
clinicaltrialsoncology@dekalbmedical.org

Northeast Georgia Medical Center-Gainesville
Gainesville 4196586, Georgia 4197000 30501
Contact:
Site Public Contact
770-219-8800
cancerpatient.navigator@nghs.com

Emory Johns Creek Hospital
Johns Creek 6331909, Georgia 4197000 30097
Contact:
Site Public Contact
404-778-5714
m.lisa.hwang@emory.edu

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah 4221552, Georgia 4197000 31405
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-524-6115
i.webster@hawaiicancercare.com

Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-532-0315

Queen's Medical Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-545-8548

Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-522-4333

Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-531-8521

The Cancer Center of Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-6881

Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-539-2273
info@hawaiicancercare.com

Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-486-6000

The Queen's Medical Center - West Oahu
‘Ewa Beach 5855051, Hawaii 5855797 96706
Contact:
Site Public Contact
rohta@queens.org

Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Alton Memorial Hospital
Alton 4232679, Illinois 4896861 62002
Contact:
Site Public Contact
618-463-7323

Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847

Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern University
Chicago 4887398, Illinois 4896861 60611
Contact:
Site Public Contact
312-695-1301
cancer@northwestern.edu

Rush University Medical Center
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-942-5498
clinical_trials@rush.edu

University of Illinois
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046

Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360

AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocate.com

Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Contact:
Site Public Contact
630-275-1270
Barbara.barhamand@advocatehealth.com

Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907

Elmhurst Memorial Hospital
Elmhurst 4891010, Illinois 4896861 60126
Contact:
Site Public Contact
630-758-5460
Jrohde@emhc.org

Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Northwestern Medicine Glenview Outpatient Center
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
312-695-1102

Northwestern Medicine Grayslake Outpatient Center
Grayslake 4894465, Illinois 4896861 60030
Contact:
Site Public Contact
312-695-1102

Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995

Edward Hines Jr VA Hospital
Hines 4896005, Illinois 4896861 60141
Contact:
Site Public Contact
708-202-8387

Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861 60045
Contact:
Site Public Contact
cancertrials@northwestern.edu

AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Loyola University Medical Center
Maywood 4901514, Illinois 4896861 60153
Contact:
Site Public Contact
708-226-4357

Edward Hospital/Cancer Center
Naperville 4903279, Illinois 4896861 60540
Contact:
Site Public Contact
630-646-6075

HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Oak Brook
Oak Brook 4904277, Illinois 4896861 60523
Contact:
Site Public Contact
nctnprogram_rhlccc@northwestern.edu

Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622

Northwestern Medicine Orland Park
Orland Park 4904937, Illinois 4896861 60462
Contact:
Site Public Contact
nctnprogram_rhlccc@northwestern.edu

Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Advocate High Tech Medical Park
Palos Heights 4905259, Illinois 4896861 60463
Contact:
Site Public Contact
ncorp@aah.org

Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621

Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861 61637
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861 61114
Contact:
Site Public Contact
779-696-9378
lkline@uwhealth.org

Memorial Hospital East
Shiloh 4249910, Illinois 4896861 62269
Contact:
Site Public Contact
314-747-9912
dschwab@wustl.edu

Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Contact:
Site Public Contact
217-528-7541
pallante.beth@mhsil.com

Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Saint Luke's Hospital
Cedar Rapids 4850751, Iowa 4862182 52402
Contact:
Site Public Contact
319-368-5514
Rachel.varner@unitypoint.org

Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673

Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727

University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Contact:
Site Public Contact
913-588-1569
OlatheCCResearch@kumc.edu

University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Hospital-Indian Creek Campus
Overland Park 4276873, Kansas 4273857 66211
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Contact:
Site Public Contact
785-452-7038
mleepers@srhc.com

Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-270-4939

University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000

University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925 40504
Contact:
Site Public Contact
720-874-1881
ResearchInstituteInquiries@CommonSpirit.org

Mary Bird Perkins Cancer Center - Metairie
Metairie 4333177, Louisiana 4331987 70002
Contact:
Site Public Contact
504-584-6990

East Jefferson General Hospital
Metairie 4333177, Louisiana 4331987 70006
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

LSU Healthcare Network / Metairie Multi-Specialty Clinic
Metairie 4333177, Louisiana 4331987 70006
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Penobscot Bay Medical Center
Rockport 4976817, Maine 4971068 04856
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Luminis Health Anne Arundel Medical Center
Annapolis 4347242, Maryland 4361885 21401
Contact:
Site Public Contact
443-481-1320
research@luminishealth.org

Maryland Proton Treatment Center
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
410-369-5226
info@mdproton.com

University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823

UM Upper Chesapeake Medical Center
Bel Air 4348240, Maryland 4361885 21014
Contact:
Site Public Contact
443-643-3010

UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885 21061
Contact:
Site Public Contact
410-553-8100

UM Capital Region Medical Center
Largo 4360345, Maryland 4361885 20774
Contact:
Site Public Contact
301-755-4397
Sarah.Larson@umm.edu

TidalHealth Richard A Henson Cancer Institute
Ocean Pines 4364326, Maryland 4361885 21811
Contact:
Site Public Contact
410-543-7067
carol.messick@peninsula.org

TidalHealth Peninsula Regional
Salisbury 4368711, Maryland 4361885 21801
Contact:
Site Public Contact
410-543-7032
monika.naegeli@peninsula.org

Beverly Hospital
Beverly 4930505, Massachusetts 6254926 01915
Contact:
Site Public Contact
978-922-3000

Lahey Hospital and Medical Center
Burlington 4931737, Massachusetts 6254926 01805
Contact:
Site Public Contact
781-744-3421
lhmc-cancer-clinical-trials@lahey.org

Addison Gilbert Hospital
Gloucester 4937829, Massachusetts 6254926 01930
Contact:
Site Public Contact
978-283-4000

Lahey Medical Center-Peabody
Peabody 4946863, Massachusetts 6254926 01960
Contact:
Site Public Contact
781-744-3421
lhmc-cancer-clinical-trials@lahey.org

Veteran's Administration Medical Center - Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48105
Contact:
Site Public Contact
800-361-8387

Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
Contact:
Site Public Contact
800-865-1125
slusserb@med.umich.edu

McLaren Cancer Institute-Bay City
Bay City 4985180, Michigan 5001836 48706
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 5001836 48183
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health Medical Center - Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

McLaren Cancer Institute-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Michigan Healthcare Professionals Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

Henry Ford Macomb Hospital-Clinton Township
Clinton Township 4989133, Michigan 5001836 48038
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836 48201
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Henry Ford Hospital
Detroit 4990729, Michigan 5001836 48202
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Michigan Healthcare Professionals Farmington
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

McLaren Cancer Institute-Flint
Flint 4992982, Michigan 5001836 48532
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Karmanos Cancer Institute at McLaren Greater Lansing
Lansing 4998830, Michigan 5001836 48910
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Contact:
Site Public Contact
517-364-3712
harsha.trivedi@umhsparrow.org

McLaren Cancer Institute-Lapeer Region
Lapeer 4998842, Michigan 5001836 48446
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Michigan Healthcare Professionals Macomb
Macomb 5000473, Michigan 5001836 48044
Contact:
Site Public Contact
rudi.ross@profoundresearch.io

Michigan Healthcare Professionals Madison Heights
Madison Heights 5000500, Michigan 5001836 48071
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

McLaren Cancer Institute-Macomb
Mount Clemens 5002656, Michigan 5001836 48043
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

McLaren Cancer Institute-Central Michigan
Mount Pleasant 5002714, Michigan 5001836 48858
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836 49120
Contact:
Site Public Contact
616-391-1230

Henry Ford Medical Center-Columbus
Novi 5004062, Michigan 5001836 48377
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

McLaren Cancer Institute-Northern Michigan
Petoskey 5005484, Michigan 5001836 49770
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

McLaren-Port Huron
Port Huron 5006233, Michigan 5001836 48060
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

MyMichigan Medical Center Saginaw
Saginaw 5007989, Michigan 5001836 48601
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph 5008327, Michigan 5001836 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

MyMichigan Medical Center Tawas
Tawas City 5011900, Michigan 5001836 48764
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695

Michigan Healthcare Professionals Troy
Troy 5012639, Michigan 5001836 48098
Contact:
Site Public Contact
rudi.ross@profoundresearch.io

Henry Ford West Bloomfield Hospital
West Bloomfield 7259621, Michigan 5001836 48322
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Saint Luke's Hospital of Duluth
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-249-7825
kdean@slhduluth.com

Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Lakeview Hospital
Stillwater 5048814, Minnesota 5037779 55082
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678 63376
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia 4381982, Missouri 4398678 65212
Contact:
Site Public Contact
573-882-7440

Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678 63141
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569

University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-7504
research@phelpshealth.org

Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520

SSM Health Saint Louis University Hospital
St Louis 4407066, Missouri 4398678 63104
Contact:
Site Public Contact
314-977-4440

Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678 63129
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569

Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678 63136
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569

BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Saint James Community Hospital and Cancer Treatment Center
Butte 5642934, Montana 5667009 59701
Contact:
Site Public Contact
406-723-2621

Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Nebraska Medicine-Bellevue
Bellevue 5063805, Nebraska 5073708 68123
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

Nebraska Medicine-Village Pointe
Omaha 5074472, Nebraska 5073708 68118
Contact:
Site Public Contact
402-559-5600

University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@dartmouth.edu

Memorial Sloan Kettering Basking Ridge
Basking Ridge 5095409, New Jersey 5101760 07920
Contact:
Site Public Contact
212-639-7592

Clara Maass Medical Center
Belleville 5095549, New Jersey 5101760 07109
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760 08103
Contact:
Site Public Contact
856-325-6757

AtlantiCare Surgery Center
Egg Harbor 8766331, New Jersey 5101760 08234
Contact:
Site Public Contact
609-748-7200

Trinitas Hospital and Comprehensive Cancer Center - Williamson Street Campus
Elizabeth 5097598, New Jersey 5101760 07207
Contact:
Site Public Contact
908-994-8000

Englewood Hospital and Medical Center
Englewood 5097672, New Jersey 5101760 07631
Contact:
Site Public Contact
201-894-3456

The Cancer Institute of New Jersey Hamilton
Hamilton 5098765, New Jersey 5101760 08690
Contact:
Site Public Contact
609-631-6946

Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760 07302
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Contact:
Site Public Contact
973-322-2934
joanne.loeb@rwjbh.org

Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
Contact:
Site Public Contact
212-639-7592

Memorial Sloan Kettering Bergen
Montvale 5101361, New Jersey 5101760 07645
Contact:
Site Public Contact
212-639-7592

Cooper CyberKnife Center
Mount Laurel 4503136, New Jersey 5101760 08054
Contact:
Site Public Contact
855-632-2667
research-cancer@cooperhealth.edu

Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356

Rutgers New Jersey Medical School
Newark 5101798, New Jersey 5101760 07101
Contact:
Site Public Contact
732-235-7356

Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760 07112
Contact:
Site Public Contact
973-926-7230
Christine.Kosmides@rwjbh.org

The Valley Hospital - Luckow Pavilion
Paramus 5102387, New Jersey 5101760 07652
Contact:
Site Public Contact
201-634-5792
clinicaltrialsresearch@valleyhealth.com

Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Contact:
Site Public Contact
908-685-2481
Siby.Varughese@rwjbh.org

Community Medical Center
Toms River 4504476, New Jersey 5101760 08755
Contact:
Site Public Contact
732-557-8294
Lennette.Gonzales@rwjbh.org

MD Anderson Cancer Center at Cooper-Voorhees
Voorhees Township 5105860, New Jersey 5101760 08043
Contact:
Site Public Contact
856-325-6757

Lovelace Medical Center-Saint Joseph Square
Albuquerque 5454711, New Mexico 5481136 87102
Contact:
Site Public Contact
505-272-0530
ZPollock@salud.unm.edu

University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Contact:
Site Public Contact
505-925-0348
HSC-ClinicalTrialInfo@salud.unm.edu

Lovelace Radiation Oncology
Albuquerque 5454711, New Mexico 5481136 87109
Contact:
Site Public Contact
505-272-0530
AYost@nmcca.org

Presbyterian Kaseman Hospital
Albuquerque 5454711, New Mexico 5481136 87110
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Northwell Health Imbert Cancer Center
Bay Shore 5108169, New York 5128638 11706
Contact:
Site Public Contact
516-734-8896

New York-Presbyterian/Brooklyn Methodist Hospital
Brooklyn 5110302, New York 5128638 11215
Contact:
Site Public Contact
718-780-3677
Adg9003@nyp.org

Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Contact:
Site Public Contact
800-767-9355
askroswell@roswellpark.org

Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
Contact:
Site Public Contact
212-639-7592

Mary Imogene Bassett Hospital
Cooperstown 5113664, New York 5128638 13326
Contact:
Site Public Contact
877-547-1750
CancerClinicalTrials@bassett.org

Noyes Memorial Hospital/Myers Cancer Center
Dansville 5114492, New York 5128638 14437
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

The New York Hospital Medical Center of Queens
Flushing 5117472, New York 5128638 11355
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Northwell Health Physicians Partners Radiation Medicine at Queens
Forest Hills 5117575, New York 5128638 11375
Contact:
Site Public Contact
718-520-6620

Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700

Northwell Health Cancer Institute at Huntington
Greenlawn 5119377, New York 5128638 11740
Contact:
Site Public Contact
516-734-8896

Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592

Northwell Health/Center for Advanced Medicine
Lake Success 5123853, New York 5128638 11042
Contact:
Site Public Contact
516-734-8896

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
Contact:
Site Public Contact
212-342-5162
cancerclinicaltrials@cumc.columbia.edu

Manhattan Eye Ear and Throat Hospital
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-434-4460

Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592

Lenox Hill Hospital
New York 5128581, New York 5128638 10075
Contact:
Site Public Contact
516-734-8896

Queens Cancer Center
Rego Park 5133640, New York 5128638 11374
Contact:
Site Public Contact
718-312-3446

Highland Hospital
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Phelps Memorial Hospital Center
Sleepy Hollow 5138371, New York 5128638 10591
Contact:
Site Public Contact
914-366-1600

Staten Island University Hospital
Staten Island 5139568, New York 5128638 10305
Contact:
Site Public Contact
718-226-8888

Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215

State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476

Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Memorial Sloan Kettering Nassau
Uniondale 5141927, New York 5128638 11553
Contact:
Site Public Contact
212-639-7592

Westchester Medical Center
Valhalla 5142090, New York 5128638 10595
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

Duke Cancer Center Cary
Cary 4459467, North Carolina 4482348 27518
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Contact:
Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu

Durham VA Medical Center
Durham 4464368, North Carolina 4482348 27705
Contact:
Site Public Contact
919-286-0411
VHADURcancertrials@va.gov

Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853

UNC Rex Healthcare
Raleigh 4487042, North Carolina 4482348 27607
Contact:
Site Public Contact
919-784-2500
CancCtrOncologyClinicalResearch@unchealth.unc.edu

Duke Cancer Center Raleigh
Raleigh 4487042, North Carolina 4482348 27609
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

UNC Rex Cancer Center of Wakefield
Raleigh 4487042, North Carolina 4482348 27614
Contact:
Site Public Contact
919-784-2500
CancCtrOncologyClinicalResearch@unchealth.unc.edu

Novant Cancer Institute Radiation Oncology - Supply
Supply 4830472, North Carolina 4482348 28462
Contact:
Site Public Contact
910-754-4716

Novant Health Cancer Institute Radiation Oncology - Wilmington
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-251-1839

Novant Health New Hanover Regional Medical Center
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-342-3000

Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-234-6161
OncologyClinicalTrialsFargo@sanfordhealth.org

Altru Cancer Center
Grand Forks 5059429, North Dakota 5690763 58201
Contact:
Site Public Contact
701-780-6520

Summa Health System - Akron Campus
Akron 5145476, Ohio 5165418 44304
Contact:
Site Public Contact
330-375-4221
cancerresearch@summahealth.org

Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

UH Seidman Cancer Center at UH Avon Health Center
Avon 5146277, Ohio 5165418 44011
Contact:
Site Public Contact
800-641-2422

Summa Health System - Barberton Campus
Barberton 5146491, Ohio 5165418 44203
Contact:
Site Public Contact
330-375-4221
cancerresearch@summahealth.org

UHHS-Chagrin Highlands Medical Center
Beachwood 5146711, Ohio 5165418 44122
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Contact:
Site Public Contact
330-363-7274
ClinicalReserachDept@aultman.com

Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418 45601
Contact:
Site Public Contact
877-779-7585
Jeffh@columbusccop.org

Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418 44109
Contact:
Site Public Contact
216-778-7559
ababal@metrohealth.org

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland 5150529, Ohio 5165418 44111
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418 44195
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Cleveland Clinic Cancer Center Mansfield
Mansfield 5161723, Ohio 5165418 44906
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Hillcrest Hospital Cancer Center
Mayfield Heights 5162188, Ohio 5165418 44124
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

Summa Health Medina Medical Center
Medina 5162512, Ohio 5165418 44256
Contact:
Site Public Contact
330-375-4221
cancerresearch@summahealth.org

UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor 5162645, Ohio 5165418 44060
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

University Hospitals Parma Medical Center
Parma 5166177, Ohio 5165418 44129
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

University Hospitals Portage Medical Center
Ravenna 5167737, Ohio 5165418 44266
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

North Coast Cancer Care
Sandusky 5170691, Ohio 5165418 44870
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

Cleveland Clinic Cancer Center Strongsville
Strongsville 5173237, Ohio 5165418 44136
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
Contact:
Site Public Contact
419-824-1842
PCIOncResearch@promedica.org

South Pointe Hospital
Warrensville Heights 5175726, Ohio 5165418 44122
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

Cleveland Clinic Wooster Family Health and Surgery Center
Wooster 5177358, Ohio 5165418 44691
Contact:
Site Public Contact
866-223-8100
TaussigResearch@ccf.org

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
Contact:
Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org

Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150

Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Oregon Health and Science University
Portland 5746545, Oregon 5744337 97239
Contact:
Site Public Contact
503-494-1080
trials@ohsu.edu

Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742

Saint Luke's Cancer Center - Allentown
Allentown 5178127, Pennsylvania 6254927 18104
Contact:
Site Public Contact
610-776-4714

UPMC Altoona
Altoona 5178195, Pennsylvania 6254927 16601
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC-Heritage Valley Health System Beaver
Beaver 5179446, Pennsylvania 6254927 15009
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Saint Luke's University Hospital-Bethlehem Campus
Bethlehem 5180225, Pennsylvania 6254927 18015
Contact:
Site Public Contact
484-503-4151

Carlisle Regional Cancer Center
Carlisle 5183234, Pennsylvania 6254927 17015
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Chambersburg Hospital
Chambersburg 4557109, Pennsylvania 6254927 17201
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Saint Luke's Hospital-Anderson Campus
Easton 5188140, Pennsylvania 6254927 18045
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Ephrata Cancer Center
Ephrata 5188815, Pennsylvania 6254927 17522
Contact:
Site Public Contact
717-721-4840

UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927 16505
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Saint Vincent Hospital
Erie 5188843, Pennsylvania 6254927 16544
Contact:
Site Public Contact
814-452-5000

UPMC Cancer Center at UPMC Horizon
Farrell 5189377, Pennsylvania 6254927 16121
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Adams Cancer Center
Gettysburg 4558183, Pennsylvania 6254927 17325
Contact:
Site Public Contact
877-441-7957

UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg 5192029, Pennsylvania 6254927 15601
Contact:
Site Public Contact
724-838-1900

UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg 5192726, Pennsylvania 6254927 17109
Contact:
Site Public Contact
717-724-6765
klitchfield@PINNACLEHEALTH.org

Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Contact:
Site Public Contact
717-531-3779
CTO@hmc.psu.edu

IRMC Cancer Center
Indiana 5194868, Pennsylvania 6254927 15701
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown 5195561, Pennsylvania 6254927 15901
Contact:
Site Public Contact
814-534-4724

Sechler Family Cancer Center
Lebanon 5197517, Pennsylvania 6254927 17042
Contact:
Site Public Contact
717-741-8303
doxenberg@wellspan.org

Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927 17837
Contact:
Site Public Contact
570-374-8555
HemonCCTrials@geisinger.edu

Yolanda G Barco Oncology Institute
Meadville 5200644, Pennsylvania 6254927 16335
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-858-7746

UPMC Cancer Center - Monroeville
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Hillman Cancer Center - Monroeville
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

UPMC Hillman Cancer Center in Coraopolis
Moon Township 5201821, Pennsylvania 6254927 15108
Contact:
Site Public Contact
412-389-5208
haneydl@upmc.edu

Allegheny Valley Hospital
Natrona Heights 5202903, Pennsylvania 6254927 15065
Contact:
Site Public Contact
Dawnmarie.DeFazio@ahn.org

Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Jefferson Torresdale Hospital
Philadelphia 4560349, Pennsylvania 6254927 19114
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Einstein Medical Center Philadelphia
Philadelphia 4560349, Pennsylvania 6254927 19141
Contact:
Site Public Contact
215-456-3880

Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000

UPMC-Saint Margaret
Pittsburgh 5206379, Pennsylvania 6254927 15215
Contact:
Site Public Contact
412-784-4900

West Penn Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15224
Contact:
Site Public Contact
412-578-5000

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073

UPMC-Shadyside Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-621-2334

UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454

UPMC-Saint Clair Hospital Cancer Center
Pittsburgh 5206379, Pennsylvania 6254927 15243
Contact:
Site Public Contact
412-502-3920

Geisinger Cancer Services-Pottsville
Pottsville 5207080, Pennsylvania 6254927 17901
Contact:
Site Public Contact
800-275-6401
HemonCCTrials@geisinger.edu

Saint Luke's Hospital - Upper Bucks Campus
Quakertown 5207381, Pennsylvania 6254927 18951
Contact:
Site Public Contact
610-776-4714

UPMC Cancer Center at UPMC Northwest
Seneca 5211432, Pennsylvania 6254927 16346
Contact:
Site Public Contact
814-676-7900

Saint Luke's Hospital - Monroe Campus
Stroudsburg 5214543, Pennsylvania 6254927 18360
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

UPMC Cancer Center-Washington
Washington 5218069, Pennsylvania 6254927 15301
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UPMC Washington Hospital Radiation Oncology
Washington 5218069, Pennsylvania 6254927 15301
Contact:
Site Public Contact
724-223-3788
cancer@washingtonhospital.org

Reading Hospital
West Reading 5218867, Pennsylvania 6254927 19611
Contact:
Site Public Contact
610-988-9323

Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
Contact:
Site Public Contact
Dawnmarie.DeFazio@ahn.org

Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Divine Providence Hospital
Williamsport 5219585, Pennsylvania 6254927 17754
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

WellSpan Health-York Cancer Center
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957

UPMC Memorial
York 4562407, Pennsylvania 6254927 17408
Contact:
Site Public Contact
717-724-6760

Saint Joseph's/Candler - Bluffton Campus
Bluffton 4571722, South Carolina 4597040 29910
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Contact:
Site Public Contact
843-792-9321
hcc-clinical-trials@musc.edu

Saint Francis Hospital
Greenville 4580543, South Carolina 4597040 29601
Contact:
Site Public Contact
864-603-6234
Heather_Rich@bshsi.org

Saint Francis Cancer Center
Greenville 4580543, South Carolina 4597040 29607
Contact:
Site Public Contact
864-603-6234
Heather_Rich@bshsi.org

Self Regional Healthcare
Greenwood 4580569, South Carolina 4597040 29646
Contact:
Site Public Contact
864-725-4771
nmcgaha@selfregional.org

Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island 4581832, South Carolina 4597040 29926
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Contact:
Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

The Children's Hospital at TriStar Centennial
Nashville 4644585, Tennessee 4662168 37203
Contact:
Site Public Contact
615-342-1919

Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168 37232
Contact:
Site Public Contact
800-811-8480

MD Anderson in The Woodlands
Conroe 4682991, Texas 4736286 77384
Contact:
Site Public Contact
866-632-6789
askmdanderson@mdanderson.org

Parkland Memorial Hospital
Dallas 4684888, Texas 4736286 75235
Contact:
Site Public Contact
214-590-5582
canceranswerline@UTSouthwestern.edu

UT Southwestern Simmons Cancer Center - RedBird
Dallas 4684888, Texas 4736286 75237
Contact:
Site Public Contact
214-648-7097
canceranswerline@utsouthwestern.edu

UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286 75390
Contact:
Site Public Contact
214-648-7097
canceranswerline@UTSouthwestern.edu

Brooke Army Medical Center
Fort Sam Houston 7267736, Texas 4736286 78234
Contact:
Site Public Contact
210-916-4837

UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth 4691930, Texas 4736286 76104
Contact:
Site Public Contact
214-648-7097
canceranswerline@UTSouthwestern.edu

M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

MD Anderson West Houston
Houston 4699066, Texas 4736286 77079
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

MD Anderson League City
League City 4705692, Texas 4736286 77573
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

UT Southwestern Clinical Center at Richardson/Plano
Richardson 4722625, Texas 4736286 75080
Contact:
Site Public Contact
972-669-7044
Suzanne.cole@utsouthwestern.edu

University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286 78229
Contact:
Site Public Contact
210-450-3800
phoresearchoffice@uthscsa.edu

MD Anderson in Sugar Land
Sugar Land 4734825, Texas 4736286 77478
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork 5844096, Utah 5549030 84003
Contact:
Site Public Contact
801-855-4100
officeofresearch@imail.org

Sandra L Maxwell Cancer Center
Cedar City 5536630, Utah 5549030 84720
Contact:
Site Public Contact
435-868-5680
officeofresearch@imail.org

Farmington Health Center
Farmington 5774662, Utah 5549030 84025
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Logan Regional Hospital
Logan 5777544, Utah 5549030 84321
Contact:
Site Public Contact
435-716-6400
officeofresearch@imail.org

Intermountain Medical Center
Murray 5778755, Utah 5549030 84107
Contact:
Site Public Contact
801-507-3950
officeofresearch@imail.org

McKay-Dee Hospital Center
Ogden 5779206, Utah 5549030 84403
Contact:
Site Public Contact
801-387-7426
officeofresearch@imail.org

Utah Valley Regional Medical Center
Provo 5780026, Utah 5549030 84604
Contact:
Site Public Contact
801-357-7965
officeofresearch@imail.org

Riverton Hospital
Riverton 5780557, Utah 5549030 84065
Contact:
Site Public Contact
801-507-3950
officeofresearch@imail.org

University of Utah Sugarhouse Health Center
Salt Lake City 5780993, Utah 5549030 84106
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

LDS Hospital
Salt Lake City 5780993, Utah 5549030 84143
Contact:
Site Public Contact
801-408-1347
officeofresearch@imail.org

Saint George Regional Medical Center
St. George 5546220, Utah 5549030 84770
Contact:
Site Public Contact
833-321-3332
officeofresearch@imail.org

Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners 5233780, Vermont 5242283 05602
Contact:
Site Public Contact
802-225-5400

University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Contact:
Site Public Contact
802-656-4101
rpo@uvm.edu

Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@hitchcock.org

University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928 22908
Contact:
Site Public Contact
434-243-6303
uvacancertrials@hscmail.mcc.virginia.edu

Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Inova Fair Oaks Hospital
Fairfax 4758023, Virginia 6254928 22033
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Bon Secours Saint Francis Medical Center
Midlothian 4772943, Virginia 6254928 23114
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Cancer Institute at Reynolds Crossing
Richmond 4781708, Virginia 6254928 23230
Contact:
Site Public Contact
804-893-8978
Anne_caramella@bshsi.org

VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928 23298
Contact:
Site Public Contact
804-628-6430
CTOclinops@vcu.edu

Virginia Mason Medical Center
Seattle 5809844, Washington 5815135 98101
Contact:
Site Public Contact
206-287-6275
cancerresearch@virginiamason.org

Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Contact:
Site Public Contact
oncologyresearch@lhs.org

Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150

Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Contact:
Site Public Contact
509-897-5993
Cheryl.Dodd@providence.org

Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Contact:
Site Public Contact
715-623-9869
Juli.Alford@aspirus.org

ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468 54911
Contact:
Site Public Contact
920-364-3604
ResearchDept@thedacare.org

Ascension Saint Elizabeth Hospital
Appleton 5244080, Wisconsin 5279468 54915
Contact:
Site Public Contact
AWRI.inquiry@ascension.org

Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468 54806
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield 5246835, Wisconsin 5279468 53045
Contact:
Site Public Contact
AWRI.Inquiry@Ascension.org

Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Ascension Calumet Hospital
Chilton 5248469, Wisconsin 5279468 53014
Contact:
Site Public Contact
AWRI.inquiry@ascension.org

Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Ascension Saint Francis - Reiman Cancer Center
Franklin 5253710, Wisconsin 5279468 53132
Contact:
Site Public Contact
AWRI.Inquiry@Ascension.org

Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Bellin Memorial Hospital
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-435-8326

Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-433-8889
WI_research_admin@hshs.org

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100

Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon 5262649, Wisconsin 5279468 53097
Contact:
Site Public Contact
AWRI.Inquiry@Ascension.org

Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53211
Contact:
Site Public Contact
AWRI.Inquiry@Ascension.org

Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666

Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Zablocki Veterans Administration Medical Center
Milwaukee 5263045, Wisconsin 5279468 53295
Contact:
Site Public Contact
888-469-6614

Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Contact:
Site Public Contact
research.institute@phci.org

Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505

ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878

Ascension Mercy Hospital
Oshkosh 5265838, Wisconsin 5279468 54904
Contact:
Site Public Contact
AWRI.inquiry@ascension.org

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Ascension All Saints Hospital
Racine 5268249, Wisconsin 5279468 53405
Contact:
Site Public Contact
AWRI.Inquiry@Ascension.org

Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
Contact:
Site Public Contact
715-847-2353
Beth.Knetter@aspirus.org

Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
Contact:
Site Public Contact
715-847-2353
Beth.Knetter@aspirus.org

Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Contact:
Site Public Contact
262-928-5539
Chanda.miller@phci.org

Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866

Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa 5278159, Wisconsin 5279468 53226
Contact:
Site Public Contact
AWRI.Inquiry@Ascension.org

Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505

Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718

More Details

NCT ID
NCT05050084
Status
Recruiting
Sponsor
NRG Oncology

Detailed Description

PRIMARY OBJECTIVES: I. To determine whether men with National Comprehensive Cancer Network (NCCN) unfavorable intermediate risk (UIR) prostate cancer and lower Decipher genomic risk (Decipher score < 0.40) treated with radiation therapy (RT) alone instead of 6 months androgen deprivation therapy (ADT) + RT experience non-inferior rate of distant metastasis. (De-intensification study) II. To determine whether men with NCCN UIR prostate cancer who are in the higher genomic risk (Decipher score >= 0.40) will have a superior metastasis-free survival through treatment intensification with darolutamide added to the standard of RT plus 6 months ADT. (Intensification study) SECONDARY OBJECTIVES: I. To compare overall survival (OS) between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. II. To compare time to prostate specific antigen (PSA) failure between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. III. To compare metastasis free survival (MFS) based on conventional imaging between the standard of care (RT plus 6 months of ADT) and de-intensification intervention (RT alone). IV. To compare MFS based on either conventional and/or molecular imaging between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. V. To compare cumulative incidence of locoregional failure based upon conventional imaging and/ or biopsy between standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months ADT plus darolutamide) interventions. VI. To compare cumulative incidence of distant metastasis based upon conventional imaging between standard of care (RT plus 6 months of ADT) and intensification intervention (RT plus 6 months ADT plus darolutamide). VII. To compare cumulative incidence of distant metastasis based upon either conventional and/or molecular imaging between standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. VIII. To compare prostate cancer-specific mortality between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. IX. To compare sexual and hormonal related quality of life, as measured by the Expanded Prostate Cancer Index Composite-26 (EPIC), between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. X. To compare fatigue, as measured by the Patient Reported Outcomes Measurement Information System (PROMIS)-Fatigue instrument, between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. XI. To compare cognition, as measured by the Functional Assessment of Chronic Illness Therapy-Cognitive (FACT-Cog) perceived cognitive abilities subscale, between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. EXPLORATORY OBJECTIVES: I. To compare changes in cardio-metabolic markers, including body mass index, lipids, blood glucose, complete blood count (CBC), comprehensive metabolic panel (CMP), and hemoglobin (Hgb) A1c, between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. II. To compare PSA failure-free survival with non-castrate testosterone and no additional therapies between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. III. To compare cumulative incidence of locoregional failure based upon either conventional and/or molecular imaging between standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. IV. To compare castrate-resistant prostate cancer (CRPC) between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. V. To compare bowel and urinary function related quality of life, as measured by the Expanded Prostate Cancer Index Composite-26 (EPIC), between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. VI. To compare time to testosterone recovery (defined as a T > 200ng/dL) between the standard of care (RT plus 6 months of ADT) and intensification (RT plus 6 months of ADT plus darolutamide) interventions. VII. To compare health utilities, as measured by the European Quality of Life Five Dimension Five Level Scale (EQ-5D-5L), between the standard of care (RT plus 6 months of ADT) and either the de-intensification (RT alone) or intensification (RT plus 6 months of ADT plus darolutamide) interventions. VIII. To develop and assess a machine learning/artificial intelligence algorithm for radiotherapy planning and/or quality assurance. IX. To perform future translational correlative studies using biological data, Decipher results, and clinical outcomes. OUTLINE: DE-INTENSIFICATION STUDY: Patients with Decipher score < 0.40 are randomized to 1 of 2 arms. ARM I: Patients undergo radiation therapy (RT) using a recognized regimen (2-3 days a week or 5 days a week for 2-11 weeks) in the absence of disease progression or unacceptable toxicity. ARM II: Patients undergo RT as Arm I. Patients also receive androgen deprivation therapy (ADT) consisting of leuprolide, goserelin, buserelin, histrelin, triptorelin, degarelix, or relugolix at the discretion of the treating physician, for 6 months in the absence of disease progression or unacceptable toxicity. Patients may also receive bicalutamide or flutamide for 0, 30 or 180 days. INTENSIFICATION STUDY: Patients with Decipher score >= 0.40 are randomized to 1 of 2 arms. ARM III: Patients receive treatment as in Arm II. ARM IV: Patients receive RT and ADT as in Arm II. Patients also receive darolutamide orally (PO) twice daily (BID). Treatment repeats every 90 days for up to 2 cycles in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 3, 6, 12, 24, 36, 48 and 60 months.