Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer

Purpose

This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy [IGRT] and chemotherapy followed by immunotherapy with durvalumab or osimertinib) versus the usual treatment alone in treating patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be treated by surgery (inoperable). SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. IGRT is a type of radiation that uses a computer to create a picture of the tumor, to help guide the radiation beam during therapy, making it more accurate and causing less damage to healthy tissue. Usual chemotherapy used in this trial consists of combinations of the following drugs: cisplatin, carboplatin, paclitaxel, nab-paclitaxel, pemetrexed, and etoposide. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds. Cisplatin works by killing, stopping, or slowing the growth of tumor cells. Carboplatin works in a way similar to the anticancer drug cisplatin but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells as well. Paclitaxel is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of tumor cells. Nab-paclitaxel is an albumin-stabilized nanoparticle formulation of paclitaxel which may have fewer side effects and work better than other forms of paclitaxel. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help tumor cells multiply. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and deoxyribonucleic acid (DNA) repair and may kill tumor cells. Immunotherapy with durvalumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Osimertinib is in a class of medications called kinase inhibitors. It works by blocking the action of a protein called EGFR that signals cancer cells to multiply. This helps slow or stop the spread of tumor cells. Adding SBRT to the usual treatment of IGRT with chemotherapy and immunotherapy may be more effective at treating patients with locally-advanced non-small cell lung cancer than giving the usual treatment alone.

Conditions

  • Locally Advanced Lung Non-Small Cell Carcinoma
  • Stage IIB Lung Cancer AJCC v8
  • Stage III Lung Cancer AJCC v8

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Pathologically (histologically or cytologically) proven diagnosis of non-operable stage IIB or III, node positive (American Joint Committee on Cancer [AJCC] eighth edition) non-small cell lung cancer (NSCLC) with known PD-L1 status prior to registration - Patients must have an identified primary tumor and at least one nodal metastasis (peribronchial/hilar/intrapulmonary, mediastinal/subcarinal, supraclavicular/scalene) - Up to 4 cycles of systemic therapy received prior to registration for the current study cancer is allowable; any prior chemotherapy for a different cancer is also permissible - Patients who refuse surgery, in addition to those who are technically unresectable or medically inoperable, are eligible. - Patients with separate tumor nodules in the same lobe of the primary tumor are eligible - The patient must be deemed clinically appropriate for curative intent definitive combined modality therapy, based on the following staging assessments: - History/physical examination prior to registration; - Magnetic resonance imaging (MRI) scan of the brain (preferred) or CT scan of the brain (if available, contrast is preferred for all neuroimaging) prior to registration; - CT chest with IV contrast (if contrast is available and unless contraindicated, such as for abnormal kidney function) prior to registration. PET/CT may be used if the CT portion is of identical diagnostic quality as achieved in a stand-alone CT - No evidence of distant metastases based on FDG PET/CT scan obtained within 60 days of registration - Primary tumor =< 7 cm - Age >= 18 - Eastern Cooperative Oncology Group (ECOG) performance status 0-2 - Hematologic function (e.g. platelets, leukocytes, hemoglobin) amenable, at the discretion of the treating physician, to allow for treatment with chemotherapy and concurrent radiation therapy - Creatinine clearance >= 25 mL/min by the Cockcroft-Gault (C-G) equation - Subjects with non-malignant pleural effusion are eligible provided the effusion is not known or demonstrated to be an exudative effusion - If a pleural effusion is present, the following criteria must be met to exclude malignant involvement: - When pleural fluid is visible on both the CT scan and on a chest x-ray, a pleuracentesis is required to confirm that the pleural fluid is cytologically negative; - Effusions that are minimal (i.e., not visible on chest x-ray) that are too small to safely tap are eligible - Medical history consistent with the patient being amenable, at the discretion of the treating physician, to allow for treating with consolidation immunotherapy. Patients with known EGFR/ALK/other driver mutation at the time of registration are eligible, and these patients can be treated with consolidation systemic therapy at the discretion of the treating physician - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen - Negative pregnancy test =< 14 days prior to registration for participants of childbearing potential - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information

Exclusion Criteria

  • Prior radiotherapy to the study cancer (local recurrence). Prior radiotherapy for a different cancer/condition to the region of the study cancer that would result in overlap of radiation therapy fields that is determined by the treating physician to impede the treatment of the study malignancy - Patients without identifiable primary tumor and at least 1 pathologically enlarged lymph node are not eligible (T3-4N0 or T0N1-3 patients are not eligible). At least 1 radiographically-involved lymph node is required, but pathologic confirmation of involvement is not mandated - Centrally located primary tumor < 2 cm from involved nodal disease that would result in significant overlap of the primary SBRT and nodal radiation fields. This does not include proximity to involved segmental and subsegmental lymph nodes (levels 13 and 14) that would not result in overlap of dose to the proximal bronchial tree or esophagus. Centrally located is defined as within or touching the zone of the proximal bronchial tree, which is a volume 2 cm in all directions around the proximal bronchial tree (carina, right and left main bronchi, right and left upper lobe bronchi, intermedius bronchus, right middle lobe bronchus, lingular bronchus right and left lower lobe bronchi) - Participants who are pregnant or unwilling to discontinue nursing - Participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) unwilling to use highly effective contraceptives during therapy and for the Food and Drug Administration (FDA)-labeled contraception timeframe required after the final dose of the selected systemic therapy regimen, because the treatment in this study may be significantly teratogenic

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Arm I (image guided RT, chemotherapy, immunotherapy) 		Patients undergo conventional IGRT and receive usual care chemotherapy consisting of paclitaxel IV followed by carboplatin IV Q7D during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT during follow-up.
  • Drug: Carboplatin
    Given IV
    Other names:
    • Blastocarb
    • Carboplat
    • Carboplatin Hexal
    • Carboplatino
    • Carboplatinum
    • Carbosin
    • Carbosol
    • Carbotec
    • CBDCA
    • Displata
    • Ercar
    • JM-8
    • JM8
    • Nealorin
    • Novoplatinum
    • Paraplatin
    • Paraplatin AQ
    • Paraplatine
    • Platinwas
    • Ribocarbo
  • Drug: Cisplatin
    Given IV
    Other names:
    • Abiplatin
    • Blastolem
    • Briplatin
    • CDDP
    • Cis-diammine-dichloroplatinum
    • Cis-diamminedichloridoplatinum
    • Cis-diamminedichloro Platinum (II)
    • Cis-diamminedichloroplatinum
    • Cis-dichloroammine Platinum (II)
    • Cis-platinous Diamine Dichloride
    • Cis-platinum
    • Cis-platinum II
    • Cis-platinum II Diamine Dichloride
    • Cismaplat
    • Cisplatina
    • Cisplatinum
    • Cisplatyl
    • Citoplatino
    • Citosin
    • Cysplatyna
    • DDP
    • Lederplatin
    • Metaplatin
    • Neoplatin
    • Peyrone's Chloride
    • Peyrone's Salt
    • Placis
    • Plastistil
    • Platamine
    • Platiblastin
    • Platiblastin-S
    • Platinex
    • Platinol
    • Platinol- AQ
    • Platinol-AQ
    • Platinol-AQ VHA Plus
    • Platinoxan
    • Platinum
    • Platinum Diamminodichloride
    • Platiran
    • Platistin
    • Platosin
  • Procedure: Computed Tomography
    Undergo CT and/or PET/CT
    Other names:
    • CAT
    • CAT Scan
    • Computed Axial Tomography
    • Computerized Axial Tomography
    • Computerized axial tomography (procedure)
    • Computerized Tomography
    • Computerized Tomography (CT) scan
    • CT
    • CT Scan
    • tomography
  • Biological: Durvalumab
    Given IV
    Other names:
    • Imfinzi
    • Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer
    • MEDI 4736
    • MEDI-4736
    • MEDI4736
  • Drug: Etoposide
    Given IV
    Other names:
    • Demethyl Epipodophyllotoxin Ethylidine Glucoside
    • EPEG
    • Lastet
    • Toposar
    • Vepesid
    • VP 16
    • VP 16-213
    • VP 16213
    • VP-16
    • VP-16-213
    • VP-16213
    • VP16
    • VP16213
  • Radiation: Image Guided Radiation Therapy
    Undergo IGRT
    Other names:
    • IGRT
    • Image Guided Radiotherapy
    • image-guided radiation therapy
    • Image-Guided Radiotherapy
  • Drug: Nab-paclitaxel
    Given IV
    Other names:
    • ABI 007
    • ABI-007
    • ABI007
    • Abraxane
    • Albumin-bound Paclitaxel
    • Albumin-Stabilized Nanoparticle Paclitaxel
    • Nanoparticle Albumin-bound Paclitaxel
    • Nanoparticle Paclitaxel
    • Naveruclif
    • Paclitaxel Albumin
    • paclitaxel albumin-stabilized nanoparticle formulation
    • Paclitaxel Nanoparticle Albumin-bound
    • Paclitaxel Protein-Bound
    • Protein-bound Paclitaxel
  • Drug: Paclitaxel
    Given IV
    Other names:
    • Anzatax
    • Asotax
    • Bristaxol
    • Praxel
    • Taxol
    • Taxol Konzentrat
  • Drug: Pemetrexed
    Given IV
    Other names:
    • MTA
    • Multitargeted Antifolate
    • Pemfexy
  • Procedure: Positron Emission Tomography
    Undergo PET/CT
    Other names:
    • Medical Imaging, Positron Emission Tomography
    • PET
    • PET Scan
    • Positron emission tomography (procedure)
    • Positron Emission Tomography Scan
    • Positron-Emission Tomography
    • PT
  • Other: Questionnaire Administration
    Ancillary studies
Experimental
Arm II (SBRT, image guided RT, chemotherapy, immunotherapy) 		Patients undergo SBRT and conventional IGRT and receive standard-of-care chemotherapy consisting of paclitaxel IV followed by carboplatin IV Q7D during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT during follow-up.
  • Drug: Carboplatin
    Given IV
    Other names:
    • Blastocarb
    • Carboplat
    • Carboplatin Hexal
    • Carboplatino
    • Carboplatinum
    • Carbosin
    • Carbosol
    • Carbotec
    • CBDCA
    • Displata
    • Ercar
    • JM-8
    • JM8
    • Nealorin
    • Novoplatinum
    • Paraplatin
    • Paraplatin AQ
    • Paraplatine
    • Platinwas
    • Ribocarbo
  • Drug: Cisplatin
    Given IV
    Other names:
    • Abiplatin
    • Blastolem
    • Briplatin
    • CDDP
    • Cis-diammine-dichloroplatinum
    • Cis-diamminedichloridoplatinum
    • Cis-diamminedichloro Platinum (II)
    • Cis-diamminedichloroplatinum
    • Cis-dichloroammine Platinum (II)
    • Cis-platinous Diamine Dichloride
    • Cis-platinum
    • Cis-platinum II
    • Cis-platinum II Diamine Dichloride
    • Cismaplat
    • Cisplatina
    • Cisplatinum
    • Cisplatyl
    • Citoplatino
    • Citosin
    • Cysplatyna
    • DDP
    • Lederplatin
    • Metaplatin
    • Neoplatin
    • Peyrone's Chloride
    • Peyrone's Salt
    • Placis
    • Plastistil
    • Platamine
    • Platiblastin
    • Platiblastin-S
    • Platinex
    • Platinol
    • Platinol- AQ
    • Platinol-AQ
    • Platinol-AQ VHA Plus
    • Platinoxan
    • Platinum
    • Platinum Diamminodichloride
    • Platiran
    • Platistin
    • Platosin
  • Procedure: Computed Tomography
    Undergo CT and/or PET/CT
    Other names:
    • CAT
    • CAT Scan
    • Computed Axial Tomography
    • Computerized Axial Tomography
    • Computerized axial tomography (procedure)
    • Computerized Tomography
    • Computerized Tomography (CT) scan
    • CT
    • CT Scan
    • tomography
  • Biological: Durvalumab
    Given IV
    Other names:
    • Imfinzi
    • Immunoglobulin G1, Anti-(Human Protein B7-H1) (Human Monoclonal MEDI4736 Heavy Chain), Disulfide with Human Monoclonal MEDI4736 Kappa-chain, Dimer
    • MEDI 4736
    • MEDI-4736
    • MEDI4736
  • Drug: Etoposide
    Given IV
    Other names:
    • Demethyl Epipodophyllotoxin Ethylidine Glucoside
    • EPEG
    • Lastet
    • Toposar
    • Vepesid
    • VP 16
    • VP 16-213
    • VP 16213
    • VP-16
    • VP-16-213
    • VP-16213
    • VP16
    • VP16213
  • Radiation: Image Guided Radiation Therapy
    Undergo IGRT
    Other names:
    • IGRT
    • Image Guided Radiotherapy
    • image-guided radiation therapy
    • Image-Guided Radiotherapy
  • Drug: Nab-paclitaxel
    Given IV
    Other names:
    • ABI 007
    • ABI-007
    • ABI007
    • Abraxane
    • Albumin-bound Paclitaxel
    • Albumin-Stabilized Nanoparticle Paclitaxel
    • Nanoparticle Albumin-bound Paclitaxel
    • Nanoparticle Paclitaxel
    • Naveruclif
    • Paclitaxel Albumin
    • paclitaxel albumin-stabilized nanoparticle formulation
    • Paclitaxel Nanoparticle Albumin-bound
    • Paclitaxel Protein-Bound
    • Protein-bound Paclitaxel
  • Drug: Paclitaxel
    Given IV
    Other names:
    • Anzatax
    • Asotax
    • Bristaxol
    • Praxel
    • Taxol
    • Taxol Konzentrat
  • Drug: Pemetrexed
    Given IV
    Other names:
    • MTA
    • Multitargeted Antifolate
    • Pemfexy
  • Procedure: Positron Emission Tomography
    Undergo PET/CT
    Other names:
    • Medical Imaging, Positron Emission Tomography
    • PET
    • PET Scan
    • Positron emission tomography (procedure)
    • Positron Emission Tomography Scan
    • Positron-Emission Tomography
    • PT
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Stereotactic Body Radiation Therapy
    Undergo SBRT
    Other names:
    • SABR
    • SBRT
    • Stereotactic Ablative Body Radiation Therapy

Recruiting Locations

University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764 35233
Contact:
Site Public Contact
205-934-0220
tmyrick@uab.edu

The Kirklin Clinic at Acton Road
Birmingham 4049979, Alabama 4829764 35243
Contact:
Site Public Contact
205-934-0220
tmyrick@uab.edu

Kingman Regional Medical Center
Kingman 5301067, Arizona 5551752 86401
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Cancer Center at Saint Joseph's
Phoenix 5308655, Arizona 5551752 85004
Contact:
Site Public Contact
720-874-1881
ResearchInstituteInquiries@CommonSpirit.org

Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752 85719
Contact:
Site Public Contact
UACC-IIT@uacc.arizona.edu

University of Arizona Cancer Center-North Campus
Tucson 5318313, Arizona 5551752 85719
Contact:
Site Public Contact
UACC-IIT@uacc.arizona.edu

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Contact:
Site Public Contact
870-936-7066
Emily.Carvell@bmhcc.org

University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274

AIS Cancer Center at San Joaquin Community Hospital
Bakersfield 5325738, California 5332921 93301
Contact:
Site Public Contact
661-323-4673

Mills-Peninsula Medical Center
Burlingame 5331920, California 5332921 94010
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Palo Alto Medical Foundation-Fremont
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Los Angeles General Medical Center
Los Angeles 5368361, California 5332921 90033
Contact:
Site Public Contact
323-865-0451
uscnorrisinfo@med.usc.edu

USC / Norris Comprehensive Cancer Center
Los Angeles 5368361, California 5332921 90033
Contact:
Site Public Contact
323-865-0451

Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400

Memorial Medical Center
Modesto 5373900, California 5332921 95355
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Palo Alto Medical Foundation-Camino Division
Mountain View 5375480, California 5332921 94040
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Sutter Roseville Medical Center
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

California Pacific Medical Center-Pacific Campus
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Mills Health Center
San Mateo 5392423, California 5332921 94401
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
415-209-2683
clinicalresearch@sutterhealth.org

Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

Sutter Solano Medical Center/Cancer Center
Vallejo 5405380, California 5332921 94589
Contact:
Site Public Contact
clinicalresearch@sutterhealth.org

UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
720-848-0650

Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618 80907
Contact:
Site Public Contact
720-874-1881
ResearchInstituteInquiries@CommonSpirit.org

UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
Contact:
Site Public Contact
719-365-2406

Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
Contact:
Site Public Contact
719-364-6700

UCHealth - Cherry Creek
Denver 5419384, Colorado 5417618 80206
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150

Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

UCHealth Highlands Ranch Hospital
Highlands Ranch 5425043, Colorado 5417618 80129
Contact:
Site Public Contact
720-848-0650

UCHealth Lone Tree Health Center
Lone Tree 5429208, Colorado 5417618 80124
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083

Beebe Medical Center
Lewes 4143354, Delaware 4142224 19958
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Beebe South Coastal Health Campus
Millville 4143696, Delaware 4142224 19967
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224 19718
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224 19801
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Morton Plant Hospital
Clearwater 4151316, Florida 4155751 33756
Contact:
Site Public Contact
855-314-8646

Halifax Health Medical Center-Centers for Oncology
Daytona Beach 4152872, Florida 4155751 32114
Contact:
Site Public Contact
386-254-4211

Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751 32224-9980
Contact:
Site Public Contact
855-776-0015

Jupiter Medical Center
Jupiter 4160610, Florida 4155751 33458
Contact:
Site Public Contact
561-745-5768

Orlando Health Cancer Institute
Orlando 4167147, Florida 4155751 32806
Contact:
Site Public Contact
321-841-7246
CancerClinicalTrials@orlandohealth.com

Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751 33607
Contact:
Site Public Contact
813-357-0849
jennifer.manns@baycare.org

Winter Haven Hospital
Winter Haven 4178552, Florida 4155751 33881
Contact:
Site Public Contact
803-293-1121
Research.CTO@baycare.org

Grady Health System
Atlanta 4180439, Georgia 4197000 30303
Contact:
Site Public Contact
404-778-1868

Emory Proton Therapy Center
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
404-251-2854
allyson.anderson@emory.edu

Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
888-946-7447

Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000 30322
Contact:
Site Public Contact
404-778-1868

Emory Saint Joseph's Hospital
Atlanta 4180439, Georgia 4197000 30342
Contact:
Site Public Contact
404-851-7115

Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Contact:
Site Public Contact
706-721-2388
ga_cares@augusta.edu

WellStar Cobb Hospital
Austell 4180564, Georgia 4197000 30106
Contact:
Site Public Contact
470-793-4071
research@wellstar.org

Hamilton Medical Center - Peeples Cancer Institute
Dalton 4190581, Georgia 4197000 30720
Contact:
Site Public Contact
706-226-8950
crogers@hhcs.org

Wellstar Kennestone Hospital
Marietta 4207783, Georgia 4197000 30060
Contact:
Site Public Contact
470-793-4071
research@wellstar.org

CTCA at Southeastern Regional Medical Center
Newnan 4212684, Georgia 4197000 30265
Contact:
Site Public Contact
770-400-6629

Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-524-6115
i.webster@hawaiicancercare.com

Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-532-0315

Queen's Medical Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-545-8548

Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-522-4333

University of Hawaii Cancer Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-586-2979

Kuakini Medical Center
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-9816

Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-531-8521

The Cancer Center of Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-6881

Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-539-2273
info@hawaiicancercare.com

Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-486-6000

Rush-Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Contact:
Site Public Contact
630-978-6212
RCMC_Cancer_Research@rush.edu

Advocate Outpatient Center - Aurora
Aurora 4883817, Illinois 4896861 60506
Contact:
Site Public Contact
ncorp@aah.org

Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847

OSF Saint Joseph Medical Center
Bloomington 4885164, Illinois 4896861 61701
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern University
Chicago 4887398, Illinois 4896861 60611
Contact:
Site Public Contact
312-695-1301
cancer@northwestern.edu

Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360

AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocate.com

Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Contact:
Site Public Contact
630-275-1270
Barbara.barhamand@advocatehealth.com

Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907

Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995

Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622

Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Advocate High Tech Medical Park
Palos Heights 4905259, Illinois 4896861 60463
Contact:
Site Public Contact
ncorp@aah.org

Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621

Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria 4905687, Illinois 4896861 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861 61637
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861 61114
Contact:
Site Public Contact
779-696-9378
lkline@uwhealth.org

Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929

Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541

Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Contact:
Site Public Contact
217-528-7541
pallante.beth@mhsil.com

Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Midwestern Regional Medical Center
Zion 4917358, Illinois 4896861 60099
Contact:
Site Public Contact
844-793-0745

Northwest Cancer Center - Main Campus
Crown Point 4919451, Indiana 4921868 46307
Contact:
Site Public Contact
219-310-2550

Northwest Oncology LLC
Dyer 4919820, Indiana 4921868 46311
Contact:
Site Public Contact
219-924-8178

Northwest Cancer Center - Hobart
Hobart 4921476, Indiana 4921868 46342
Contact:
Site Public Contact
219-947-1795

Saint Mary Medical Center
Hobart 4921476, Indiana 4921868 46342
Contact:
Site Public Contact
219-836-6875
CancerResearch@COMHS.org

The Community Hospital
Munster 4924014, Indiana 4921868 46321
Contact:
Site Public Contact
219-836-3349

Women's Diagnostic Center - Munster
Munster 4924014, Indiana 4921868 46321
Contact:
Site Public Contact
219-934-8869
mnicholson@comhs.org

Northwest Cancer Center - Valparaiso
Valparaiso 4927537, Indiana 4921868 46383
Contact:
Site Public Contact
219-836-6875
CancerResearch@COMHS.org

Mary Greeley Medical Center
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-956-4132

McFarland Clinic - Ames
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-239-4734
ksoder@mcfarlandclinic.com

UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305

Saint Luke's Hospital
Cedar Rapids 4850751, Iowa 4862182 52402
Contact:
Site Public Contact
319-368-5514
Rachel.varner@unitypoint.org

UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305

Heartland Oncology and Hematology LLP
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
712-322-4136

Methodist Jennie Edmundson Hospital
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
402-354-7939
kathryn.bartz@nmhs.org

Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727

UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305

UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305

UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305

University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Contact:
Site Public Contact
913-588-1569
OlatheCCResearch@kumc.edu

University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Contact:
Site Public Contact
785-452-7038
mleepers@srhc.com

University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000

University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379

Louisiana State University Health Science Center
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Cancer Care Center of York County
Sanford 4977762, Maine 4971068 04073
Contact:
Site Public Contact
207-459-1600

MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Greater Baltimore Medical Center
Baltimore 4347778, Maryland 4361885 21204
Contact:
Site Public Contact
443-849-3706

Sinai Hospital of Baltimore
Baltimore 4347778, Maryland 4361885 21215
Contact:
Site Public Contact
410-601-9083

TidalHealth Richard A Henson Cancer Institute
Ocean Pines 4364326, Maryland 4361885 21811
Contact:
Site Public Contact
410-543-7067
carol.messick@peninsula.org

TidalHealth Peninsula Regional
Salisbury 4368711, Maryland 4361885 21801
Contact:
Site Public Contact
410-543-7032
monika.naegeli@peninsula.org

William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster 4373238, Maryland 4361885 21157
Contact:
Site Public Contact
410-871-6400

UMass Memorial Medical Center - University Campus
Worcester 4956184, Massachusetts 6254926 01655
Contact:
Site Public Contact
508-856-3216
cancer.research@umassmed.edu

Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

McLaren Cancer Institute-Bay City
Bay City 4985180, Michigan 5001836 48706
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

McLaren Cancer Institute-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Michigan Healthcare Professionals Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836 48201
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Michigan Healthcare Professionals Farmington
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health Farmington Hills Hospital
Farmington Hills 4992523, Michigan 5001836 48336
Contact:
Site Public Contact
248-551-7695

McLaren Cancer Institute-Flint
Flint 4992982, Michigan 5001836 48532
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Beacon Kalamazoo
Kalamazoo 4997787, Michigan 5001836 49048
Contact:
Site Public Contact
574-647-7370

Karmanos Cancer Institute at McLaren Greater Lansing
Lansing 4998830, Michigan 5001836 48910
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Contact:
Site Public Contact
517-364-3712
harsha.trivedi@umhsparrow.org

McLaren Cancer Institute-Lapeer Region
Lapeer 4998842, Michigan 5001836 48446
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Michigan Healthcare Professionals Macomb
Macomb 5000473, Michigan 5001836 48044
Contact:
Site Public Contact
rudi.ross@profoundresearch.io

Michigan Healthcare Professionals Madison Heights
Madison Heights 5000500, Michigan 5001836 48071
Contact:
Site Public Contact
941-833-5700
rudi.ross@profoundresearch.io

McLaren Cancer Institute-Macomb
Mount Clemens 5002656, Michigan 5001836 48043
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

McLaren Cancer Institute-Northern Michigan
Petoskey 5005484, Michigan 5001836 49770
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Michigan Healthcare Professionals Pontiac
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
248-858-6215
Emily.Crofts@trinity-health.org

Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

McLaren-Port Huron
Port Huron 5006233, Michigan 5001836 48060
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695

Michigan Healthcare Professionals Troy
Troy 5012639, Michigan 5001836 48098
Contact:
Site Public Contact
rudi.ross@profoundresearch.io

Henry Ford Health Warren Hospital
Warren 5014051, Michigan 5001836 48093
Contact:
Site Public Contact
313-343-3166
kforman1@hfhs.org

University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Contact:
Site Public Contact
218-333-5000
OncologyClinicalTrialsFargo@sanfordhealth.org

Essentia Health Saint Joseph's Medical Center
Brainerd 5019116, Minnesota 5037779 56401
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779 56636
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health Saint Mary's Medical Center
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779 55746
Contact:
Site Public Contact
218-786-3308

Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015

Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud 5044407, Minnesota 5037779 56303
Contact:
Site Public Contact
877-229-4907
coborncancercenter@centracare.com

Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779 55072
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779 55792
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569

Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Contact:
Site Public Contact
417-347-4030
LJCrockett@freemanhealth.com

University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520

Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
Contact:
Site Public Contact
314-525-6042
Danielle.Werle@mercy.net

Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066

Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569

BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-334-4773

Nebraska Methodist Hospital
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-354-5144

Renown Regional Medical Center
Reno 5511077, Nevada 5509151 89502
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@dartmouth.edu

Memorial Sloan Kettering Basking Ridge
Basking Ridge 5095409, New Jersey 5101760 07920
Contact:
Site Public Contact
212-639-7592

Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760 08103
Contact:
Site Public Contact
856-325-6757

The Cancer Institute of New Jersey Hamilton
Hamilton 5098765, New Jersey 5101760 08690
Contact:
Site Public Contact
609-631-6946

Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760 07302
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Monmouth Medical Center Southern Campus
Lakewood 5100280, New Jersey 5101760 08701
Contact:
Site Public Contact
732-923-6564
mary.danish@rwjbh.org

Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Contact:
Site Public Contact
973-322-2934
joanne.loeb@rwjbh.org

Monmouth Medical Center
Long Branch 5100619, New Jersey 5101760 07740
Contact:
Site Public Contact
732-923-6564
mary.danish@rwjbh.org

Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
Contact:
Site Public Contact
212-639-7592

Memorial Sloan Kettering Bergen
Montvale 5101361, New Jersey 5101760 07645
Contact:
Site Public Contact
212-639-7592

Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356

Rutgers New Jersey Medical School
Newark 5101798, New Jersey 5101760 07101
Contact:
Site Public Contact
732-235-7356

Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Contact:
Site Public Contact
908-685-2481
Siby.Varughese@rwjbh.org

Community Medical Center
Toms River 4504476, New Jersey 5101760 08755
Contact:
Site Public Contact
732-557-8294
Lennette.Gonzales@rwjbh.org

University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Contact:
Site Public Contact
505-925-0348
HSC-ClinicalTrialInfo@salud.unm.edu

Presbyterian Kaseman Hospital
Albuquerque 5454711, New Mexico 5481136 87110
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Memorial Medical Center-Las Cruces
Las Cruces 5475352, New Mexico 5481136 88011
Contact:
Site Public Contact
575-556-6545
Deborah.Brown@LPNT.net

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Wilmot Cancer Center at Batavia
Batavia 5108093, New York 5128638 14020
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

Sands Cancer Center
Canandaigua 5111405, New York 5128638 14424
Contact:
Site Public Contact
585-396-6161

Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
Contact:
Site Public Contact
212-639-7592

Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700

Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592

New York Proton Center
New York 5128581, New York 5128638 10035
Contact:
Site Public Contact
646-968-9031
ichoi@nyproton.com

Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592

Wilmot Cancer Institute Radiation Oncology at Greece
Rochester 5134086, New York 5128638 14606
Contact:
Site Public Contact
585-758-7877

Highland Hospital
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215

State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476

Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Montefiore Medical Center-Weiler Hospital
The Bronx 5110266, New York 5128638 10461
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
Contact:
Site Public Contact
718-379-6866
eskwak@montefiore.org

Memorial Sloan Kettering Nassau
Uniondale 5141927, New York 5128638 11553
Contact:
Site Public Contact
212-639-7592

Westchester Medical Center
Valhalla 5142090, New York 5128638 10595
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Contact:
Site Public Contact
WCICTOresearch@urmc.rochester.edu

Atrium Health Stanly/LCI-Albemarle
Albemarle 4452303, North Carolina 4482348 28002
Contact:
Site Public Contact
800-804-9376

Duke Cancer Center Cary
Cary 4459467, North Carolina 4482348 27518
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Contact:
Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu

Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348 28203
Contact:
Site Public Contact
800-804-9376

Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348 28204
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Atrium Health Pineville/LCI-Pineville
Charlotte 4460243, North Carolina 4482348 28210
Contact:
Site Public Contact
980-442-2000

Atrium Health University City/LCI-University
Charlotte 4460243, North Carolina 4482348 28262
Contact:
Site Public Contact
800-804-9376

Wake Forest University at Clemmons
Clemmons 4461015, North Carolina 4482348 27012
Contact:
Site Public Contact
888-716-9259

Atrium Health Cabarrus/LCI-Concord
Concord 4461574, North Carolina 4482348 28025
Contact:
Site Public Contact
800-804-9376

Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853

Levine Cancer Institute - Rutherford
Forest City 4466720, North Carolina 4482348 28043
Contact:
Site Public Contact
800-804-9376

CaroMont Regional Medical Center
Gastonia 4467732, North Carolina 4482348 28054
Contact:
Site Public Contact
704-834-2810
tammy.cozad@caromonthealth.org

Novant Health Breast Surgery - Greensboro
Greensboro 4469146, North Carolina 4482348 27403
Contact:
Site Public Contact
336-718-8335
pjordan@novanthealth.org

Novant Health Cancer Institute - Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Novant Health Presbyterian Medical Center Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Novant Health Cancer Institute - Kernersville
Kernersville 4474221, North Carolina 4482348 27284
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Levine Cancer Institute - Union West
Matthews 4478334, North Carolina 4482348 28104
Contact:
Site Public Contact
980-442-0600

Matthews Radiation Oncology Center
Matthews 4478334, North Carolina 4482348 28105
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Novant Health Cancer Institute - Matthews
Matthews 4478334, North Carolina 4482348 28105
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Atrium Health Union/LCI-Union
Monroe 4479946, North Carolina 4482348 28112
Contact:
Site Public Contact
980-442-2000

Novant Health Cancer Institute - Mooresville
Mooresville 4480125, North Carolina 4482348 28117
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Novant Health Cancer Institute - Mount Airy
Mount Airy 4480378, North Carolina 4482348 27030
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Novant Health Cancer Institute - Wilkesboro
North Wilkesboro 4482577, North Carolina 4482348 28659
Contact:
Site Public Contact
336-718-8335
pjordan@novanthealth.org

Duke Cancer Center Raleigh
Raleigh 4487042, North Carolina 4482348 27609
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

Novant Health Cancer Institute - Rowan
Salisbury 4489985, North Carolina 4482348 28144
Contact:
Site Public Contact
980-201-6360
kashah@novanthealth.org

Rowan Regional Medical Center
Salisbury 4489985, North Carolina 4482348 28144
Contact:
Site Public Contact
704-210-5000
nnechiporchik@novanthealth.org

Atrium Health Cleveland/LCI-Cleveland
Shelby 4491180, North Carolina 4482348 28150
Contact:
Site Public Contact
800-804-9376

Novant Health Cancer Institute - Statesville
Statesville 4493316, North Carolina 4482348 28625
Contact:
Site Public Contact
336-718-8335
pjordan@novanthealth.org

Wake Forest Baptist Health - Hematology Oncology - Statesville
Statesville 4493316, North Carolina 4482348 28677
Contact:
Site Public Contact
704-872-3630

Novant Cancer Institute Radiation Oncology - Supply
Supply 4830472, North Carolina 4482348 28462
Contact:
Site Public Contact
910-754-4716

Novant Health Cancer Institute - Thomasville
Thomasville 4494942, North Carolina 4482348 27360
Contact:
Site Public Contact
336-718-8335
pjordan@novanthealth.org

Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro 4499138, North Carolina 4482348 28659
Contact:
Site Public Contact
888-716-9253

Novant Health Cancer Institute Radiation Oncology - Wilmington
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-251-1839

Novant Health New Hanover Regional Medical Center
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-342-3000

Novant Health Forsyth Medical Center
Winston-Salem 4499612, North Carolina 4482348 27103
Contact:
Site Public Contact
336-718-8335
pjordan@novanthealth.org

Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348 27157
Contact:
Site Public Contact
336-713-6771

Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-234-6161
OncologyClinicalTrialsFargo@sanfordhealth.org

Altru Cancer Center
Grand Forks 5059429, North Dakota 5690763 58201
Contact:
Site Public Contact
701-780-6520

Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

UH Seidman Cancer Center at UH Avon Health Center
Avon 5146277, Ohio 5165418 44011
Contact:
Site Public Contact
800-641-2422

UHHS-Chagrin Highlands Medical Center
Beachwood 5146711, Ohio 5165418 44122
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Cleveland Clinic Mercy Hospital
Canton 5149222, Ohio 5165418 44708
Contact:
Site Public Contact
888-293-4673

Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Contact:
Site Public Contact
330-363-7274
ClinicalReserachDept@aultman.com

Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320

Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Grady Memorial Hospital
Delaware 5151891, Ohio 5165418 43015
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515

OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
Contact:
Site Public Contact
614-788-3860
Jennifer.Sexton@ohiohealth.com

UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor 5162645, Ohio 5165418 44060
Contact:
Site Public Contact
800-641-2422
CTUReferral@UHhospitals.org

Mercy Health - Perrysburg Hospital
Perrysburg 5166516, Ohio 5165418 43551
Contact:
Site Public Contact
614-488-2745
Jeffh@columbusccop.org

Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150

Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742

Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Chambersburg Hospital
Chambersburg 4557109, Pennsylvania 6254927 17201
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Ephrata Cancer Center
Ephrata 5188815, Pennsylvania 6254927 17522
Contact:
Site Public Contact
717-721-4840

Adams Cancer Center
Gettysburg 4558183, Pennsylvania 6254927 17325
Contact:
Site Public Contact
877-441-7957

Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Contact:
Site Public Contact
717-531-3779
CTO@hmc.psu.edu

Lancaster General Ann B Barshinger Cancer Institute
Lancaster 5197079, Pennsylvania 6254927 17601
Contact:
Site Public Contact
717-544-0511
nctn@pennmedicine.upenn.edu

Sechler Family Cancer Center
Lebanon 5197517, Pennsylvania 6254927 17042
Contact:
Site Public Contact
717-741-8303
doxenberg@wellspan.org

Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927 17837
Contact:
Site Public Contact
570-374-8555
HemonCCTrials@geisinger.edu

University of Pennsylvania/Abramson Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19104
Contact:
Site Public Contact
855-216-0098
PennCancerTrials@careboxhealth.com

Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19111
Contact:
Site Public Contact
215-728-4790

Temple University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19140
Contact:
Site Public Contact
215-728-2983

Reading Hospital
West Reading 5218867, Pennsylvania 6254927 19611
Contact:
Site Public Contact
610-988-9323

Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Contact:
Site Public Contact
570-271-5251
HemonCCTrials@geisinger.edu

Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Contact:
Site Public Contact
215-600-9151
ONCTrialNow@jefferson.edu

Lankenau Medical Center
Wynnewood 5220230, Pennsylvania 6254927 19096
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

WellSpan Health-York Cancer Center
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957

WellSpan Health-York Hospital
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957

Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040 29341
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Lancaster Radiation Therapy Center
Lancaster 4584556, South Carolina 4597040 29720
Contact:
Site Public Contact
800-804-9376

Rock Hill Radiation Therapy Center
Rock Hill 4593142, South Carolina 4597040 29730
Contact:
Site Public Contact
800-804-9376

Levine Cancer Institute-Rock Hill
Rock Hill 4593142, South Carolina 4597040 29732
Contact:
Site Public Contact
800-804-9376

Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040 29379
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Lexington Medical Center
West Columbia 4600541, South Carolina 4597040 29169
Contact:
Site Public Contact
803-935-8300
research@lexhealth.org

Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Contact:
Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

MD Anderson in The Woodlands
Conroe 4682991, Texas 4736286 77384
Contact:
Site Public Contact
866-632-6789
askmdanderson@mdanderson.org

M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

MD Anderson West Houston
Houston 4699066, Texas 4736286 77079
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

MD Anderson League City
League City 4705692, Texas 4736286 77573
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

MD Anderson in Sugar Land
Sugar Land 4734825, Texas 4736286 77478
Contact:
Site Public Contact
877-632-6789
askmdanderson@mdanderson.org

Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners 5233780, Vermont 5242283 05602
Contact:
Site Public Contact
802-225-5400

University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Contact:
Site Public Contact
802-656-4101
rpo@uvm.edu

University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283 05405
Contact:
Site Public Contact
802-656-8990
rpo@uvm.edu

Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@hitchcock.org

Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Contact:
Site Public Contact
oncologyresearch@lhs.org

Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150

Edwards Comprehensive Cancer Center
Huntington 4809537, West Virginia 4826850 25701
Contact:
Site Public Contact
304-399-6566
Christina.Cole@chhi.org

West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Contact:
Site Public Contact
715-623-9869
Juli.Alford@aspirus.org

Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468 54806
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468 54806
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-433-8889
WI_research_admin@hshs.org

Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Essentia Health-Hayward Clinic
Hayward 5255882, Wisconsin 5279468 54843
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

William S Middleton VA Medical Center
Madison 5261457, Wisconsin 5279468 53705
Contact:
Site Public Contact
608-256-1901

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100

Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666

Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Zablocki Veterans Administration Medical Center
Milwaukee 5263045, Wisconsin 5279468 53295
Contact:
Site Public Contact
888-469-6614

Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Contact:
Site Public Contact
research.institute@phci.org

Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505

ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
Contact:
Site Public Contact
715-847-2353
Beth.Knetter@aspirus.org

Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Essentia Health-Spooner Clinic
Spooner 5274034, Wisconsin 5279468 54801
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
Contact:
Site Public Contact
715-847-2353
Beth.Knetter@aspirus.org

Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Contact:
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800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
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Site Public Contact
920-433-8889
wi_research_admin@hshs.org

Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
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Site Public Contact
414-302-2304
ncorp@aurora.org

Essentia Health Saint Mary's Hospital - Superior
Superior 5275191, Wisconsin 5279468 54880
Contact:
Site Public Contact
701-364-6272

UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Contact:
Site Public Contact
262-928-5539
Chanda.miller@phci.org

Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866

Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
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Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
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Site Public Contact
414-302-2304
ncorp@aurora.org

Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505

Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
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Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718

More Details

NCT ID
NCT05624996
Status
Recruiting
Sponsor
NRG Oncology

Detailed Description

PRIMARY OBJECTIVES: I. To compare the overall survival in patients with stage II-IIIC inoperable node-positive non-small cell lung cancer (NSCLC) after image guided, motion-managed conventional radiotherapy to the primary tumor and nodal metastases (Arm 1) or after image guided, motion-managed stereotactic body radiation therapy (SBRT) to the primary tumor followed by conventionally fractionated radiotherapy to nodal metastases (Arm 2) both given with concurrent platinum-based chemotherapy. II. To compare progression-free survival between the experimental arm (Arm 2) and control arm (Arm 1). SECONDARY OBJECTIVES: I. To compare objective response rate (as defined by Response Evaluation Criteria in Solid Tumors [RECIST] version [v] 1.1) between the experimental arm and control arm. II. To compare the rate of local control between the experimental arm and control arm. III. To compare patterns of failure (primary, locoregional, or distant) between the experimental arm and control arm. IV. To compare changes in pulmonary function (forced expiratory volume in 1 second [FEV1] and diffusion capacity of the lung for carbon monoxide [DLCO] assessed at randomization and at 6- and 12- months following completion of radiation therapy) between the experimental arm and control arm. V. To compare changes in quality of life and patient-reported outcomes assessed from pre-treatment to 3 months following radiation therapy of each treatment arm. VI. To determine acute and late toxicity profiles of each treatment arm as measured by the Common Terminology Criteria for Adverse Events (CTCAE) v5. EXPLORATORY OBJECTIVES: I. To characterize and compare longitudinal quality of life and patient-reported outcomes of each treatment arm. II. To collect biospecimens at baseline, after SBRT (for Arm 2 patients), during last 2 weeks of chemoradiation, and after first dose of consolidation therapy, to allow for future analyses. III. To collect 4-dimensional (4D) computed tomography (CT) planning scans and radiation dose to calculate regional lung ventilation and explore pre-treatment 4D-CT based ventilation to predict pulmonary toxicity. IV. To characterize clinical outcomes, toxicities and changes in pulmonary function and quality of life among patients receiving proton and photon radiotherapy. V. To develop and characterize a machine learning/artificial intelligence algorithm for radiotherapy planning and/or quality assurance. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo conventional IGRT and receive usual care chemotherapy consisting of paclitaxel intravenously (IV) followed by carboplatin IV weekly (Q7D) during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or positron emission tomography (PET)/CT during follow-up. ARM II: Patients undergo SBRT and conventional IGRT and receive standard-of-care chemotherapy consisting of paclitaxel IV followed by carboplatin IV Q7D during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT during follow-up. Patients are followed up every 3 months for 1 year, every 6 months during years 2 and 3, and then yearly after that for the duration of the study.