Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab
Purpose
The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observation will result in the same risk of cancer coming back as pembrolizumab after surgery in triple-negative breast cancer patients who achieve pathologic complete response after preoperative chemotherapy with pembrolizumab.
Conditions
- Anatomic Stage I Breast Cancer AJCC v8
- Anatomic Stage II Breast Cancer AJCC v8
- Anatomic Stage III Breast Cancer AJCC v8
- Early Stage Triple-Negative Breast Carcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Age >= 18 years - Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2 - Triple Negative Breast Cancer: - Patients with a history of stage T1cN1-2 or T2-4N0-2 breast cancer according to the primary tumor-regional lymph node anatomic staging criteria of the American Joint Committee on Cancer (AJCC), 8th edition as determined by the investigator in radiologic assessment, clinical assessment or both - Patients must have no residual invasive disease in the breast or lymph nodes after the completion of neoadjuvant therapy. Residual ductal carcinoma in situ (DCIS) is allowed. Isolated tumor cells are considered node-negative - Estrogen (ER) and progesterone (PR) =< 10%; HER2-negative by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines (immunohistochemistry [IHC] and fluorescence in situ hybridization [FISH]) - If invasive disease was present in both breasts, participation in the study is permitted as long as the eligibility criteria are met for both tumors/breasts - Patients must have received neoadjuvant chemotherapy in combination with pembrolizumab for a minimum of 6 cycles. All systemic chemotherapy and ICI therapy should have been completed preoperatively - An interval of no more than 12 weeks between the completion date of the final surgery and the date of randomization * Note: Adjuvant radiation can be given on study. If given, it is encouraged to be given concurrently with pembrolizumab, per investigator discretion. Treatment with adjuvant pembrolizumab is strongly discouraged prior to participation in this trial, but if administered (e.g., if patients are awaiting pathology results), pembrolizumab may be administered for up to 6 weeks post-surgery and must be completed prior to registration - Use of investigational anti-cancer agents must be discontinued at time of registration - Adequate excision: Surgical removal of all clinically evident disease in the breast and lymph nodes as follows: - Breast surgery: Total mastectomy or breast-conserving surgery with histologically negative margins, including no ink on tumor for DCIS, at the time of excision ** For patients who undergo breast-conserving surgery, the margins of the resected specimen must be histologically free of ductal carcinoma in-situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates DCIS at the line of resection, additional operative procedures may be performed to obtain clear margins. If DCIS is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. Patients with margins positive for classic lobular carcinoma in situ (LCIS) are eligible without additional resection - Lymph node surgery: - For a patient with clinically N0 disease, a sentinel lymph node biopsy should have been performed at time of surgical evaluation, and if pathologically node positive, the patient is no longer eligible. Isolated tumor cells are considered node-negative - For a patient with clinically N1 disease at diagnosis (with positive results from a fine-needle aspiration, core biopsy, or sentinel node biopsy performed prior to preoperative therapy) additional surgical evaluation of the axilla following preoperative therapy is required *** If they become cN0 (no palpable adenopathy), then a sentinel lymph node biopsy could have been performed at time of surgery (axillary dissection would also be permitted); if the sentinel lymph node biopsy is positive, the patient is no longer eligible - If sentinel node biopsy performed before preoperative therapy was negative, no additional surgical evaluation of the axilla is required after preoperative therapy. If sentinel node biopsy performed before preoperative therapy was positive, an ALND is required after preoperative therapy - If the only sentinel node identified by isotope scan is in the internal mammary chain, surgical evaluation of the axilla is still required - If sentinel node evaluation after preoperative therapy is negative, no further additional surgical evaluation of the axilla is required - Axillary dissection without sentinel node evaluation is permitted as the initial or sole axillary evaluation after preoperative therapy - If breast-conserving surgery was performed but patient will not be receiving breast radiation, the patient is not eligible - Not pregnant and not nursing, because this study involves an agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =< 7 days prior to randomization is required - Absolute neutrophil count (ANC) >= 1,000/mm^3 - Platelet Count >= 100,000/mm^3 - Estimated glomerular filtration rate (eGFR) >= 15 mL/min/1.73m^2 - Total Bilirubin =<1.5 x upper limit of normal (ULN) * Patients with Gilbert's disease with a total bilirubin =< 2.5 x ULN and direct bilirubin within normal limits are permitted - Aspartate aminotransferase (AST) serum aspartate aminotransferase [SGOT] / alanine aminotransferase (ALT) serum glutamic pyruvic transaminase [SGPT] =< 3 x institutional ULN - Patients must be willing to provide tumor tissue from the diagnostic core biopsy. If inadequate tumor tissue is available, patients are still eligible to participate in the trial - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial - Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial
Exclusion Criteria
- No stage IV (metastatic) breast cancer - No history of any prior (ipsi- or contralateral) invasive breast cancer. Prior DCIS is allowed - No evidence of recurrent disease following preoperative therapy and surgery - No known active liver disease, e.g. due to hepatitis B virus (HBV), hepatitis C virus (HCV), autoimmune hepatic disorders, or sclerosing cholangitis - No history of intolerance, including Grade 3 or 4 infusion reaction or hypersensitivity to pembrolizumab or murine proteins or any components of the product * Note: Prior immune-related adverse events (irAEs) are allowed if they resolved and the patient tolerated subsequent therapy without requiring chronic steroids for the irAE - No medical conditions that require chronic systemic steroids (>10 mg prednisone daily or equivalent) or any other form of immunosuppressive medications and has required such therapy in the last two years. Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic therapy - Patients who are unable or unwilling to comply with the requirements of the protocol per investigator assessment are not eligible
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Arm I (pembrolizumab) |
Patients receive pembrolizumab IV on study. Patients also undergo tumor biopsy on study, and collection of blood on study and during follow-up. |
|
|
Experimental Arm II (observation) |
Patients undergo observation on study. Patients also undergo tumor biopsy on study, and collection of blood on study and during follow-up. |
|
Recruiting Locations
CTCA at Western Regional Medical Center
Goodyear, Arizona 85338
Goodyear, Arizona 85338
Contact:
Site Public Contact
623-207-3000
Site Public Contact
623-207-3000
Kingman Regional Medical Center
Kingman, Arizona 86401
Kingman, Arizona 86401
Cancer Center at Saint Joseph's
Phoenix, Arizona 85004
Phoenix, Arizona 85004
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
Phoenix, Arizona 85054
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Highlands Oncology Group - Fayetteville
Fayetteville, Arkansas 72703
Fayetteville, Arkansas 72703
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Highlands Oncology Group - Rogers
Rogers, Arkansas 72758
Rogers, Arkansas 72758
Highlands Oncology Group
Springdale, Arkansas 72762
Springdale, Arkansas 72762
PCR Oncology
Arroyo Grande, California 93420
Arroyo Grande, California 93420
Tower Cancer Research Foundation
Beverly Hills, California 90211
Beverly Hills, California 90211
Marshall Cancer Center
Cameron Park, California 95682
Cameron Park, California 95682
Mercy Cancer Center - Carmichael
Carmichael, California 95608
Carmichael, California 95608
Mercy San Juan Medical Center
Carmichael, California 95608
Carmichael, California 95608
Kaiser Permanente Dublin
Dublin, California 94568
Dublin, California 94568
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Mercy Cancer Center - Elk Grove
Elk Grove, California 95758
Elk Grove, California 95758
Kaiser Permanente-Fremont
Fremont, California 94538
Fremont, California 94538
Kaiser Permanente-Fresno
Fresno, California 93720
Fresno, California 93720
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine, California 92612
Irvine, California 92612
Cedars Sinai Medical Center
Los Angeles, California 90048
Los Angeles, California 90048
Contact:
Site Public Contact
310-423-8965
Site Public Contact
310-423-8965
Fremont - Rideout Cancer Center
Marysville, California 95901
Marysville, California 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Kaiser Permanente-Modesto
Modesto, California 95356
Modesto, California 95356
Kaiser Permanente-Oakland
Oakland, California 94611
Oakland, California 94611
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
Orange, California 92868
Desert Regional Medical Center
Palm Springs, California 92262
Palm Springs, California 92262
Contact:
Site Public Contact
760-416-4730
Site Public Contact
760-416-4730
Stanford Cancer Institute Palo Alto
Palo Alto, California 94304
Palo Alto, California 94304
Huntington Memorial Hospital
Pasadena, California 91105
Pasadena, California 91105
Contact:
Site Public Contact
626-535-2420
Site Public Contact
626-535-2420
Mercy Cancer Center - Rocklin
Rocklin, California 95765
Rocklin, California 95765
Kaiser Permanente-Roseville
Roseville, California 95661
Roseville, California 95661
Kaiser Permanente Downtown Commons
Sacramento, California 95814
Sacramento, California 95814
Mercy Cancer Center - Sacramento
Sacramento, California 95816
Sacramento, California 95816
Kaiser Permanente-South Sacramento
Sacramento, California 95823
Sacramento, California 95823
Salinas Valley Memorial
Salinas, California 93901
Salinas, California 93901
Kaiser Permanente-San Francisco
San Francisco, California 94115
San Francisco, California 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
San Jose, California 95119
Stanford Cancer Center South Bay
San Jose, California 95124
San Jose, California 95124
Kaiser Permanente San Leandro
San Leandro, California 94577
San Leandro, California 94577
Kaiser San Rafael-Gallinas
San Rafael, California 94903
San Rafael, California 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
Santa Clara, California 95051
Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
Santa Rosa, California 95403
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
South San Francisco, California 94080
Cedars-Sinai Cancer - Tarzana
Tarzana, California 91356
Tarzana, California 91356
Contact:
Site Public Contact
818-981-3818
Site Public Contact
818-981-3818
Torrance Memorial Physician Network - Cancer Care
Torrance, California 90505
Torrance, California 90505
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
Truckee, California 96161
Contact:
Site Public Contact
530-582-6450
Site Public Contact
530-582-6450
Kaiser Permanente-Vallejo
Vallejo, California 94589
Vallejo, California 94589
Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
Walnut Creek, California 94596
Woodland Memorial Hospital
Woodland, California 95695
Woodland, California 95695
UCHealth University of Colorado Hospital
Aurora, Colorado 80045
Aurora, Colorado 80045
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
Colorado Springs, Colorado 80909
Contact:
Site Public Contact
719-365-2406
Site Public Contact
719-365-2406
Memorial Hospital North
Colorado Springs, Colorado 80920
Colorado Springs, Colorado 80920
Contact:
Site Public Contact
719-364-6700
Site Public Contact
719-364-6700
Kaiser Permanente-Franklin
Denver, Colorado 80205
Denver, Colorado 80205
UCHealth - Cherry Creek
Denver, Colorado 80206
Denver, Colorado 80206
UCHealth Highlands Ranch Hospital
Highlands Ranch, Colorado 80129
Highlands Ranch, Colorado 80129
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
Lafayette, Colorado 80026
Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124
Lone Tree, Colorado 80124
UCHealth Lone Tree Health Center
Lone Tree, Colorado 80124
Lone Tree, Colorado 80124
Hartford HealthCare - Saint Vincent's Medical Center
Bridgeport, Connecticut 06606
Bridgeport, Connecticut 06606
Contact:
Site Public Contact
860-972-4700
Site Public Contact
860-972-4700
Danbury Hospital
Danbury, Connecticut 06810
Danbury, Connecticut 06810
Contact:
Site Public Contact
203-739-8074
Site Public Contact
203-739-8074
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
Derby, Connecticut 06418
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
Fairfield, Connecticut 06824
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
Glastonbury, Connecticut 06033
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
Greenwich, Connecticut 06830
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut 06437
Guilford, Connecticut 06437
Hartford Hospital
Hartford, Connecticut 06102
Hartford, Connecticut 06102
Contact:
Site Public Contact
860-545-5363
Site Public Contact
860-545-5363
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
Hartford, Connecticut 06105
Midstate Medical Center
Meriden, Connecticut 06451
Meriden, Connecticut 06451
Contact:
Site Public Contact
866-662-5678
Site Public Contact
866-662-5678
The Hospital of Central Connecticut
New Britain, Connecticut 06050
New Britain, Connecticut 06050
Contact:
Site Public Contact
860-224-5660
Site Public Contact
860-224-5660
Yale University
New Haven, Connecticut 06520
New Haven, Connecticut 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
North Haven, Connecticut 06473
Norwalk Hospital
Norwalk, Connecticut 06856
Norwalk, Connecticut 06856
Smilow Cancer Hospital Care Center at Long Ridge
Stamford, Connecticut 06902
Stamford, Connecticut 06902
Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
Torrington, Connecticut 06790
Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
Trumbull, Connecticut 06611
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
Waterbury, Connecticut 06708
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut 06385
Waterford, Connecticut 06385
Beebe South Coastal Health Campus
Millville, Delaware 19967
Millville, Delaware 19967
Helen F Graham Cancer Center
Newark, Delaware 19713
Newark, Delaware 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Newark, Delaware 19713
Beebe Health Campus
Rehoboth Beach, Delaware 19971
Rehoboth Beach, Delaware 19971
MedStar Georgetown University Hospital
Washington, District of Columbia 20007
Washington, District of Columbia 20007
Contact:
Site Public Contact
202-444-2223
Site Public Contact
202-444-2223
MedStar Washington Hospital Center
Washington, District of Columbia 20010
Washington, District of Columbia 20010
Contact:
Site Public Contact
202-877-8839
Site Public Contact
202-877-8839
Morton Plant Hospital
Clearwater, Florida 33756
Clearwater, Florida 33756
Contact:
Site Public Contact
855-314-8646
Site Public Contact
855-314-8646
Broward Health Medical Center
Fort Lauderdale, Florida 33316
Fort Lauderdale, Florida 33316
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
Jacksonville, Florida 32224-9980
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Orlando Health Cancer Institute
Orlando, Florida 32806
Orlando, Florida 32806
Memorial Hospital West
Pembroke Pines, Florida 33028
Pembroke Pines, Florida 33028
Contact:
Site Public Contact
954-265-4325
Site Public Contact
954-265-4325
Mease Countryside Hospital
Safety Harbor, Florida 34695
Safety Harbor, Florida 34695
Tallahassee Memorial HealthCare
Tallahassee, Florida 32308
Tallahassee, Florida 32308
Contact:
Site Public Contact
850-431-0673
Site Public Contact
850-431-0673
Tampa General Hospital
Tampa, Florida 33606
Tampa, Florida 33606
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida 33607
Tampa, Florida 33607
Phoebe Putney Memorial Hospital
Albany, Georgia 31701
Albany, Georgia 31701
Grady Health System
Atlanta, Georgia 30303
Atlanta, Georgia 30303
Contact:
Site Public Contact
404-489-9164
Site Public Contact
404-489-9164
Emory University Hospital Midtown
Atlanta, Georgia 30308
Atlanta, Georgia 30308
Contact:
Site Public Contact
888-946-7447
Site Public Contact
888-946-7447
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
Atlanta, Georgia 30322
Contact:
Site Public Contact
404-778-1868
Site Public Contact
404-778-1868
Emory Saint Joseph's Hospital
Atlanta, Georgia 30342
Atlanta, Georgia 30342
Contact:
Site Public Contact
404-851-7115
Site Public Contact
404-851-7115
Northside Hospital
Atlanta, Georgia 30342
Atlanta, Georgia 30342
Augusta Oncology Associates PC-D'Antignac
Augusta, Georgia 30901
Augusta, Georgia 30901
Contact:
Site Public Contact
706-821-2944
Site Public Contact
706-821-2944
Augusta Oncology Associates PC-Wheeler
Augusta, Georgia 30909
Augusta, Georgia 30909
Contact:
Site Public Contact
706-736-1830
Site Public Contact
706-736-1830
Northside Hospital - Duluth
Duluth, Georgia 30096
Duluth, Georgia 30096
Northside Hospital - Gwinnett
Lawrenceville, Georgia 30046
Lawrenceville, Georgia 30046
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
Savannah, Georgia 31405
Hawaii Cancer Care - Westridge
'Aiea, Hawaii 96701
'Aiea, Hawaii 96701
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
Queen's Cancer Cenrer - POB I
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-532-0315
Site Public Contact
808-532-0315
Queen's Medical Center
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-545-8548
Site Public Contact
808-545-8548
Straub Clinic and Hospital
Honolulu, Hawaii 96813
Honolulu, Hawaii 96813
Contact:
Site Public Contact
808-522-4333
Site Public Contact
808-522-4333
Queen's Cancer Center - Kuakini
Honolulu, Hawaii 96817
Honolulu, Hawaii 96817
Contact:
Site Public Contact
808-531-8521
Site Public Contact
808-531-8521
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819
Honolulu, Hawaii 96819
Kapiolani Medical Center for Women and Children
Honolulu, Hawaii 96826
Honolulu, Hawaii 96826
Contact:
Site Public Contact
808-983-6090
Site Public Contact
808-983-6090
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Boise, Idaho 83706
Saint Luke's Cancer Institute - Boise
Boise, Idaho 83712
Boise, Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
Caldwell, Idaho 83605
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho 83814
Coeur d'Alene, Idaho 83814
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho 83619
Fruitland, Idaho 83619
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho 83642
Meridian, Idaho 83642
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho 83686
Nampa, Idaho 83686
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
Nampa, Idaho 83687
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho 83854
Post Falls, Idaho 83854
Kootenai Clinic Cancer Services - Sandpoint
Sandpoint, Idaho 83864
Sandpoint, Idaho 83864
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho 83301
Twin Falls, Idaho 83301
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
Barrington, Illinois 60010
Contact:
Site Public Contact
847-842-4847
Site Public Contact
847-842-4847
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Bloomington, Illinois 61704
Illinois CancerCare-Canton
Canton, Illinois 61520
Canton, Illinois 61520
SIH Cancer Institute
Carterville, Illinois 62918
Carterville, Illinois 62918
Illinois CancerCare-Carthage
Carthage, Illinois 62321
Carthage, Illinois 62321
Centralia Oncology Clinic
Centralia, Illinois 62801
Centralia, Illinois 62801
Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
University of Illinois
Chicago, Illinois 60612
Chicago, Illinois 60612
Contact:
Site Public Contact
312-355-3046
Site Public Contact
312-355-3046
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
Chicago, Illinois 60637
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
Chicago, Illinois 60657
Contact:
Site Public Contact
773-296-5360
Site Public Contact
773-296-5360
AMG Crystal Lake - Oncology
Crystal Lake, Illinois 60014
Crystal Lake, Illinois 60014
Carle at The Riverfront
Danville, Illinois 61832
Danville, Illinois 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Decatur, Illinois 62526
Decatur Memorial Hospital
Decatur, Illinois 62526
Decatur, Illinois 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
DeKalb, Illinois 60115
Illinois CancerCare-Dixon
Dixon, Illinois 61021
Dixon, Illinois 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
Downers Grove, Illinois 60515
Crossroads Cancer Center
Effingham, Illinois 62401
Effingham, Illinois 62401
Advocate Sherman Hospital
Elgin, Illinois 60123
Elgin, Illinois 60123
Contact:
Site Public Contact
847-429-2907
Site Public Contact
847-429-2907
Illinois CancerCare-Eureka
Eureka, Illinois 61530
Eureka, Illinois 61530
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
Evanston, Illinois 60201
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Geneva, Illinois 60134
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
Glenview, Illinois 60026
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois 60026
Glenview, Illinois 60026
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois 60030
Grayslake, Illinois 60030
Contact:
Site Public Contact
312-695-1102
Site Public Contact
312-695-1102
Ingalls Memorial Hospital
Harvey, Illinois 60426
Harvey, Illinois 60426
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
Hazel Crest, Illinois 60429
Contact:
Site Public Contact
708-799-9995
Site Public Contact
708-799-9995
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
Highland Park, Illinois 60035
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Kewanee, Illinois 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
Lake Forest, Illinois 60045
AMG Libertyville - Oncology
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Condell Memorial Hospital
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Illinois CancerCare-Macomb
Macomb, Illinois 61455
Macomb, Illinois 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Mattoon, Illinois 61938
Trinity Medical Center
Moline, Illinois 61265
Moline, Illinois 61265
Contact:
Site Public Contact
309-779-2000
Site Public Contact
309-779-2000
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
New Lenox, Illinois 60451
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
Oak Lawn, Illinois 60453-2699
Contact:
Site Public Contact
800-323-8622
Site Public Contact
800-323-8622
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
Orland Park, Illinois 60462
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
Orland Park, Illinois 60462
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Ottawa, Illinois 61350
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
Park Ridge, Illinois 60068
Contact:
Site Public Contact
847-384-3621
Site Public Contact
847-384-3621
Illinois CancerCare-Pekin
Pekin, Illinois 61554
Pekin, Illinois 61554
Illinois CancerCare-Peoria
Peoria, Illinois 61615
Peoria, Illinois 61615
Illinois CancerCare-Peru
Peru, Illinois 61354
Peru, Illinois 61354
Illinois CancerCare-Princeton
Princeton, Illinois 61356
Princeton, Illinois 61356
OSF Saint Anthony Medical Center
Rockford, Illinois 61108
Rockford, Illinois 61108
Contact:
Site Public Contact
815-227-2633
Site Public Contact
815-227-2633
UW Health Carbone Cancer Center Rockford
Rockford, Illinois 61114
Rockford, Illinois 61114
Southern Illinois University School of Medicine
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Memorial Medical Center
Springfield, Illinois 62781
Springfield, Illinois 62781
Carle Cancer Center
Urbana, Illinois 61801
Urbana, Illinois 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Warrenville, Illinois 60555
Illinois CancerCare - Washington
Washington, Illinois 61571
Washington, Illinois 61571
IU Health West Hospital
Avon, Indiana 46123
Avon, Indiana 46123
IU Health North Hospital
Carmel, Indiana 46032
Carmel, Indiana 46032
Northwest Cancer Center - Main Campus
Crown Point, Indiana 46307
Crown Point, Indiana 46307
Contact:
Site Public Contact
219-310-2550
Site Public Contact
219-310-2550
Northwest Oncology LLC
Dyer, Indiana 46311
Dyer, Indiana 46311
Contact:
Site Public Contact
219-924-8178
Site Public Contact
219-924-8178
Northwest Cancer Center - Hobart
Hobart, Indiana 46342
Hobart, Indiana 46342
Contact:
Site Public Contact
219-947-1795
Site Public Contact
219-947-1795
Saint Mary Medical Center
Hobart, Indiana 46342
Hobart, Indiana 46342
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
Saint Catherine Hospital
Indianapolis, Indiana 46312
Indianapolis, Indiana 46312
The Community Hospital
Munster, Indiana 46321
Munster, Indiana 46321
Contact:
Site Public Contact
219-836-3349
Site Public Contact
219-836-3349
Women's Diagnostic Center - Munster
Munster, Indiana 46321
Munster, Indiana 46321
Baptist Health Floyd
New Albany, Indiana 47150
New Albany, Indiana 47150
Northwest Cancer Center - Valparaiso
Valparaiso, Indiana 46383
Valparaiso, Indiana 46383
Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa 52402
Cedar Rapids, Iowa 52402
Contact:
Site Public Contact
319-297-2900
Site Public Contact
319-297-2900
Mercy Hospital
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
Heartland Oncology and Hematology LLP
Council Bluffs, Iowa 51503
Council Bluffs, Iowa 51503
Contact:
Site Public Contact
712-322-4136
Site Public Contact
712-322-4136
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa 51503
Council Bluffs, Iowa 51503
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Iowa City, Iowa 52242
Contact:
Site Public Contact
800-237-1225
Site Public Contact
800-237-1225
Cancer Center of Kansas - Chanute
Chanute, Kansas 66720
Chanute, Kansas 66720
Cancer Center of Kansas - Dodge City
Dodge City, Kansas 67801
Dodge City, Kansas 67801
Cancer Center of Kansas - El Dorado
El Dorado, Kansas 67042
El Dorado, Kansas 67042
HaysMed
Hays, Kansas 67601
Hays, Kansas 67601
Contact:
Site Public Contact
785-623-5774
Site Public Contact
785-623-5774
Cancer Center of Kansas-Independence
Independence, Kansas 67301
Independence, Kansas 67301
University of Kansas Cancer Center
Kansas City, Kansas 66160
Kansas City, Kansas 66160
Cancer Center of Kansas-Kingman
Kingman, Kansas 67068
Kingman, Kansas 67068
Lawrence Memorial Hospital
Lawrence, Kansas 66044
Lawrence, Kansas 66044
Cancer Center of Kansas-Liberal
Liberal, Kansas 67905
Liberal, Kansas 67905
Cancer Center of Kansas - McPherson
McPherson, Kansas 67460
McPherson, Kansas 67460
Cancer Center of Kansas - Newton
Newton, Kansas 67114
Newton, Kansas 67114
Olathe Health Cancer Center
Olathe, Kansas 66061
Olathe, Kansas 66061
Menorah Medical Center
Overland Park, Kansas 66209
Overland Park, Kansas 66209
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Overland Park, Kansas 66210
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas 66211
Overland Park, Kansas 66211
Cancer Center of Kansas - Parsons
Parsons, Kansas 67357
Parsons, Kansas 67357
Cancer Center of Kansas - Pratt
Pratt, Kansas 67124
Pratt, Kansas 67124
Cancer Center of Kansas - Salina
Salina, Kansas 67401
Salina, Kansas 67401
Salina Regional Health Center
Salina, Kansas 67401
Salina, Kansas 67401
University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606
Topeka, Kansas 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
Cancer Center of Kansas - Wellington
Wellington, Kansas 67152
Wellington, Kansas 67152
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
Westwood, Kansas 66205
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas 67208
Wichita, Kansas 67208
Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214
Wichita, Kansas 67214
Cancer Center of Kansas - Wichita
Wichita, Kansas 67214
Wichita, Kansas 67214
Cancer Center of Kansas - Winfield
Winfield, Kansas 67156
Winfield, Kansas 67156
Baptist Health Corbin
Corbin, Kentucky 40701
Corbin, Kentucky 40701
Contact:
Site Public Contact
859-523-1934
Site Public Contact
859-523-1934
Baptist Health Hardin
Elizabethtown, Kentucky 42701
Elizabethtown, Kentucky 42701
Contact:
Site Public Contact
270-706-5470
Site Public Contact
270-706-5470
Baptist Health Lexington
Lexington, Kentucky 40503
Lexington, Kentucky 40503
Contact:
Site Public Contact
859-260-6425
Site Public Contact
859-260-6425
Baptist Health Hamburg
Lexington, Kentucky 40509
Lexington, Kentucky 40509
Contact:
Site Public Contact
866-213-3025
Site Public Contact
866-213-3025
University of Kentucky/Markey Cancer Center
Lexington, Kentucky 40536
Lexington, Kentucky 40536
Contact:
Site Public Contact
859-257-3379
Site Public Contact
859-257-3379
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky 40202
Louisville, Kentucky 40202
Contact:
Site Public Contact
502-562-3429
Site Public Contact
502-562-3429
Baptist Health Louisville
Louisville, Kentucky 40207
Louisville, Kentucky 40207
UofL Health Medical Center Northeast
Louisville, Kentucky 40245
Louisville, Kentucky 40245
Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Medical Center of Baton Rouge
Baton Rouge, Louisiana 70816
Baton Rouge, Louisiana 70816
Louisiana Hematology Oncology Associates
Baton Rouge, Louisiana 70817
Baton Rouge, Louisiana 70817
Ochsner High Grove
Baton Rouge, Louisiana 70836
Baton Rouge, Louisiana 70836
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington, Louisiana 70433
Covington, Louisiana 70433
Terrebonne General Medical Center
Houma, Louisiana 70360
Houma, Louisiana 70360
University Medical Center New Orleans
New Orleans, Louisiana 70112
New Orleans, Louisiana 70112
CHRISTUS Highland Medical Center
Shreveport, Louisiana 71105
Shreveport, Louisiana 71105
Luminis Health Anne Arundel Medical Center
Annapolis, Maryland 21401
Annapolis, Maryland 21401
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
Baltimore, Maryland 21201
Contact:
Site Public Contact
800-888-8823
Site Public Contact
800-888-8823
Sinai Hospital of Baltimore
Baltimore, Maryland 21215
Baltimore, Maryland 21215
Walter Reed National Military Medical Center
Bethesda, Maryland 20889-5600
Bethesda, Maryland 20889-5600
Contact:
Site Public Contact
301-319-2100
Site Public Contact
301-319-2100
FMH James M Stockman Cancer Institute
Frederick, Maryland 21702
Frederick, Maryland 21702
Contact:
Site Public Contact
301-668-7043
Site Public Contact
301-668-7043
William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster, Maryland 21157
Westminster, Maryland 21157
Contact:
Site Public Contact
410-871-6400
Site Public Contact
410-871-6400
Tufts Medical Center
Boston, Massachusetts 02111
Boston, Massachusetts 02111
Boston Medical Center
Boston, Massachusetts 02118
Boston, Massachusetts 02118
Contact:
Site Public Contact
617-638-8265
Site Public Contact
617-638-8265
Beth Israel Deaconess Medical Center
Boston, Massachusetts 02215
Boston, Massachusetts 02215
Contact:
Site Public Contact
617-667-9925
Site Public Contact
617-667-9925
Dana-Farber Cancer Institute
Boston, Massachusetts 02215
Boston, Massachusetts 02215
Contact:
Site Public Contact
877-442-3324
Site Public Contact
877-442-3324
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
Ann Arbor, Michigan 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
Contact:
Site Public Contact
800-865-1125
Site Public Contact
800-865-1125
Bronson Battle Creek
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Trinity Health Medical Center - Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan 48188
Canton, Michigan 48188
Trinity Health Medical Center - Canton
Canton, Michigan 48188
Canton, Michigan 48188
Chelsea Hospital
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
Clinton Township, Michigan 48038
Henry Ford Hospital
Detroit, Michigan 48202
Detroit, Michigan 48202
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan 48503
Flint, Michigan 48503
Genesee Hematology Oncology PC
Flint, Michigan 48503
Flint, Michigan 48503
Genesys Hurley Cancer Institute
Flint, Michigan 48503
Flint, Michigan 48503
Hurley Medical Center
Flint, Michigan 48503
Flint, Michigan 48503
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
West Michigan Cancer Center
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
Ascension Borgess Cancer Center
Kalamazoo, Michigan 49009
Kalamazoo, Michigan 49009
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
Livonia, Michigan 48154
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan 48044
Macomb, Michigan 48044
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
Muskegon, Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan 49120
Niles, Michigan 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan 49444
Norton Shores, Michigan 49444
Henry Ford Health Providence Novi Hospital
Novi, Michigan 48374
Novi, Michigan 48374
Henry Ford Medical Center-Columbus
Novi, Michigan 48377
Novi, Michigan 48377
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Corewell Health Reed City Hospital
Reed City, Michigan 49677
Reed City, Michigan 49677
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
Saginaw, Michigan 48601
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
Saginaw, Michigan 48604
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Henry Ford Health Providence Southfield Hospital
Southfield, Michigan 48075
Southfield, Michigan 48075
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
Tawas City, Michigan 48764
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
West Bloomfield, Michigan 48322
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
West Branch, Michigan 48661
University of Michigan Health - West
Wyoming, Michigan 49519
Wyoming, Michigan 49519
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
Ypsilanti, Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
Ypsilanti, Michigan 48197
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota 56401
Brainerd, Minnesota 56401
Minnesota Oncology - Burnsville
Burnsville, Minnesota 55337
Burnsville, Minnesota 55337
Mercy Hospital
Coon Rapids, Minnesota 55433
Coon Rapids, Minnesota 55433
Essentia Health - Deer River Clinic
Deer River, Minnesota 56636
Deer River, Minnesota 56636
Essentia Health Cancer Center
Duluth, Minnesota 55805
Duluth, Minnesota 55805
Fairview Southdale Hospital
Edina, Minnesota 55435
Edina, Minnesota 55435
Essentia Health Hibbing Clinic
Hibbing, Minnesota 55746
Hibbing, Minnesota 55746
Contact:
Site Public Contact
218-786-3308
Site Public Contact
218-786-3308
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
Maplewood, Minnesota 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
Minneapolis, Minnesota 55407
Hennepin County Medical Center
Minneapolis, Minnesota 55415
Minneapolis, Minnesota 55415
University of Minnesota/Masonic Cancer Center
Minneapolis, Minnesota 55455
Minneapolis, Minnesota 55455
Contact:
Site Public Contact
612-624-2620
Site Public Contact
612-624-2620
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
Robbinsdale, Minnesota 55422
Mayo Clinic in Rochester
Rochester, Minnesota 55905
Rochester, Minnesota 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
Saint Cloud, Minnesota 56303
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
Saint Louis Park, Minnesota 55416
Regions Hospital
Saint Paul, Minnesota 55101
Saint Paul, Minnesota 55101
United Hospital
Saint Paul, Minnesota 55102
Saint Paul, Minnesota 55102
Essentia Health Sandstone
Sandstone, Minnesota 55072
Sandstone, Minnesota 55072
Essentia Health Virginia Clinic
Virginia, Minnesota 55792
Virginia, Minnesota 55792
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi 39705
Columbus, Mississippi 39705
Baptist Cancer Center-Grenada
Grenada, Mississippi 38901
Grenada, Mississippi 38901
University of Mississippi Medical Center
Jackson, Mississippi 39216
Jackson, Mississippi 39216
Contact:
Site Public Contact
601-815-6700
Site Public Contact
601-815-6700
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652
New Albany, Mississippi 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655
Oxford, Mississippi 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
Southhaven, Mississippi 38671
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
MU Health - University Hospital/Ellis Fischel Cancer Center
Columbia, Missouri 65212
Columbia, Missouri 65212
Contact:
Site Public Contact
573-882-7440
Site Public Contact
573-882-7440
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
Creve Coeur, Missouri 63141
Parkland Health Center - Farmington
Farmington, Missouri 63640
Farmington, Missouri 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Centerpoint Medical Center LLC
Independence, Missouri 64057
Independence, Missouri 64057
University Health Truman Medical Center
Kansas City, Missouri 64108
Kansas City, Missouri 64108
Contact:
Site Public Contact
816-404-4375
Site Public Contact
816-404-4375
Saint Luke's Hospital of Kansas City
Kansas City, Missouri 64111
Kansas City, Missouri 64111
Research Medical Center
Kansas City, Missouri 64132
Kansas City, Missouri 64132
University of Kansas Cancer Center - North
Kansas City, Missouri 64154
Kansas City, Missouri 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit, Missouri 64064
Lee's Summit, Missouri 64064
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri 64086
Lee's Summit, Missouri 64086
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City, Missouri 64116
North Kansas City, Missouri 64116
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
Saint Joseph, Missouri 64506
Washington University School of Medicine
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
Siteman Cancer Center-South County
Saint Louis, Missouri 63129
Saint Louis, Missouri 63129
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Siteman Cancer Center at Christian Hospital
Saint Louis, Missouri 63136
Saint Louis, Missouri 63136
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
Saint Louis, Missouri 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri 63376
Saint Peters, Missouri 63376
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
Sainte Genevieve, Missouri 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield, Missouri 65804
Springfield, Missouri 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield, Missouri 65807
Springfield, Missouri 65807
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
Sullivan, Missouri 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
Sunset Hills, Missouri 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Community Hospital of Anaconda
Anaconda, Montana 59711
Anaconda, Montana 59711
Billings Clinic Cancer Center
Billings, Montana 59101
Billings, Montana 59101
Bozeman Health Deaconess Hospital
Bozeman, Montana 59715
Bozeman, Montana 59715
Benefis Sletten Cancer Institute
Great Falls, Montana 59405
Great Falls, Montana 59405
Kalispell Regional Medical Center
Kalispell, Montana 59901
Kalispell, Montana 59901
Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
Missoula, Montana 59802
Community Medical Center
Missoula, Montana 59804
Missoula, Montana 59804
Nebraska Medicine-Bellevue
Bellevue, Nebraska 68123
Bellevue, Nebraska 68123
Mary Lanning Memorial Hospital
Hastings, Nebraska 68901
Hastings, Nebraska 68901
Contact:
Site Public Contact
402-460-5899
Site Public Contact
402-460-5899
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Contact:
Site Public Contact
402-334-4773
Site Public Contact
402-334-4773
Nebraska Methodist Hospital
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Contact:
Site Public Contact
402-354-5144
Site Public Contact
402-354-5144
Oncology Associates PC
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Nebraska Medicine-Village Pointe
Omaha, Nebraska 68118
Omaha, Nebraska 68118
Contact:
Site Public Contact
402-559-5600
Site Public Contact
402-559-5600
University of Nebraska Medical Center
Omaha, Nebraska 68198
Omaha, Nebraska 68198
OptumCare Cancer Care at Seven Hills
Henderson, Nevada 89052
Henderson, Nevada 89052
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
Renown Regional Medical Center
Reno, Nevada 89502
Reno, Nevada 89502
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire 03301
Concord, New Hampshire 03301
Contact:
Site Public Contact
603-224-2556
Site Public Contact
603-224-2556
Solinsky Center for Cancer Care
Manchester, New Hampshire 03103
Manchester, New Hampshire 03103
Contact:
Site Public Contact
800-339-6484
Site Public Contact
800-339-6484
Englewood Hospital and Medical Center
Englewood, New Jersey 07631
Englewood, New Jersey 07631
Contact:
Site Public Contact
201-894-3456
Site Public Contact
201-894-3456
Hackensack University Medical Center
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
Contact:
Site Public Contact
551-996-2897
Site Public Contact
551-996-2897
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey 08690
Hamilton, New Jersey 08690
Contact:
Site Public Contact
609-631-6946
Site Public Contact
609-631-6946
Jersey City Medical Center
Jersey City, New Jersey 07302
Jersey City, New Jersey 07302
Monmouth Medical Center Southern Campus
Lakewood, New Jersey 08701
Lakewood, New Jersey 08701
Saint Barnabas Medical Center
Livingston, New Jersey 07039
Livingston, New Jersey 07039
Monmouth Medical Center
Long Branch, New Jersey 07740
Long Branch, New Jersey 07740
Morristown Medical Center
Morristown, New Jersey 07960
Morristown, New Jersey 07960
Contact:
Site Public Contact
973-971-5900
Site Public Contact
973-971-5900
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08903
New Brunswick, New Jersey 08903
Contact:
Site Public Contact
732-235-7356
Site Public Contact
732-235-7356
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey 07652
Paramus, New Jersey 07652
Valley Health System Ridgewood Campus
Ridgewood, New Jersey 07450
Ridgewood, New Jersey 07450
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey 08080
Sewell, New Jersey 08080
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey 08876
Somerville, New Jersey 08876
Overlook Hospital
Summit, New Jersey 07902
Summit, New Jersey 07902
Contact:
Site Public Contact
908-522-2043
Site Public Contact
908-522-2043
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
Albuquerque, New Mexico 87106
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico 87124
Rio Rancho, New Mexico 87124
Northwell Health Imbert Cancer Center
Bay Shore, New York 11706
Bay Shore, New York 11706
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
Montefiore Medical Center-Einstein Campus
Bronx, New York 10461
Bronx, New York 10461
Maimonides Medical Center
Brooklyn, New York 11219
Brooklyn, New York 11219
Contact:
Site Public Contact
718-765-2500
Site Public Contact
718-765-2500
NYU Langone Hospital - Brooklyn
Brooklyn, New York 11220
Brooklyn, New York 11220
Roswell Park Cancer Institute
Buffalo, New York 14263
Buffalo, New York 14263
Hematology Oncology Associates of CNY at Camillus
Camillus, New York 13031
Camillus, New York 13031
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York 13057
East Syracuse, New York 13057
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
Northwell Health Cancer Institute at Huntington
Greenlawn, New York 11740
Greenlawn, New York 11740
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
Lake Success, New York 11042
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
NYU Langone Hospital - Long Island
Mineola, New York 11501
Mineola, New York 11501
Northern Westchester Hospital
Mount Kisco, New York 10549
Mount Kisco, New York 10549
Mount Sinai Chelsea
New York, New York 10011
New York, New York 10011
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
New York, New York 10016
Lenox Hill Hospital
New York, New York 10021
New York, New York 10021
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
Mount Sinai Hospital
New York, New York 10029
New York, New York 10029
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
New York, New York 10032
Manhattan Eye Ear and Throat Hospital
New York, New York 10065
New York, New York 10065
Contact:
Site Public Contact
212-434-4460
Site Public Contact
212-434-4460
Vassar Brothers Medical Center
Poughkeepsie, New York 12601
Poughkeepsie, New York 12601
Contact:
Site Public Contact
845-483-6483
Site Public Contact
845-483-6483
Pluta Cancer Center
Rochester, New York 14623
Rochester, New York 14623
University of Rochester
Rochester, New York 14642
Rochester, New York 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
Phelps Memorial Hospital Center
Sleepy Hollow, New York 10591
Sleepy Hollow, New York 10591
Contact:
Site Public Contact
914-366-1600
Site Public Contact
914-366-1600
Staten Island University Hospital
Staten Island, New York 10305
Staten Island, New York 10305
Contact:
Site Public Contact
718-226-8888
Site Public Contact
718-226-8888
Stony Brook University Medical Center
Stony Brook, New York 11794
Stony Brook, New York 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
Cone Health Cancer Center at Asheboro
Asheboro, North Carolina 27203
Asheboro, North Carolina 27203
Contact:
Site Public Contact
336-832-0836
Site Public Contact
336-832-0836
Randolph Health Cancer Center
Asheboro, North Carolina 27203
Asheboro, North Carolina 27203
Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina 27215
Burlington, North Carolina 27215
Rex Hematology Oncology Associates-Cary
Cary, North Carolina 27518
Cary, North Carolina 27518
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
Chapel Hill, North Carolina 27599
Novant Health Presbyterian Medical Center
Charlotte, North Carolina 28204
Charlotte, North Carolina 28204
Rex Hematology Oncology Associates-Garner
Garner, North Carolina 27529
Garner, North Carolina 27529
Cone Health Cancer Center
Greensboro, North Carolina 27403
Greensboro, North Carolina 27403
Cone Health Cancer Center at Drawbridge Parkway
Greensboro, North Carolina 27410
Greensboro, North Carolina 27410
East Carolina University
Greenville, North Carolina 27834
Greenville, North Carolina 27834
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
Hendersonville, North Carolina 28791
Novant Health Cancer Institute - Huntersville
Huntersville, North Carolina 28078
Huntersville, North Carolina 28078
Novant Health Presbyterian Medical Center Huntersville
Huntersville, North Carolina 28078
Huntersville, North Carolina 28078
Novant Health Cancer Institute - Kernersville
Kernersville, North Carolina 27284
Kernersville, North Carolina 27284
Novant Health Cancer Institute - Matthews
Matthews, North Carolina 28105
Matthews, North Carolina 28105
Novant Health Cancer Institute - Mooresville
Mooresville, North Carolina 28117
Mooresville, North Carolina 28117
Novant Health Cancer Institute - Mount Airy
Mount Airy, North Carolina 27030
Mount Airy, North Carolina 27030
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina 28374
Pinehurst, North Carolina 28374
UNC Rex Healthcare
Raleigh, North Carolina 27607
Raleigh, North Carolina 27607
UNC Rex Cancer Center of Wakefield
Raleigh, North Carolina 27614
Raleigh, North Carolina 27614
Annie Penn Memorial Hospital
Reidsville, North Carolina 27320
Reidsville, North Carolina 27320
Novant Health Cancer Institute - Rowan
Salisbury, North Carolina 28144
Salisbury, North Carolina 28144
Rowan Regional Medical Center
Salisbury, North Carolina 28144
Salisbury, North Carolina 28144
Novant Health Cancer Institute - Thomasville
Thomasville, North Carolina 27360
Thomasville, North Carolina 27360
Marion L Shepard Cancer Center - ECU Health Beaufort Hospital
Washington, North Carolina 27889
Washington, North Carolina 27889
Novant Health Forsyth Medical Center
Winston-Salem, North Carolina 27103
Winston-Salem, North Carolina 27103
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Sanford Broadway Medical Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Summa Health System - Akron Campus
Akron, Ohio 44304
Akron, Ohio 44304
Summa Health System - Barberton Campus
Barberton, Ohio 44203
Barberton, Ohio 44203
Strecker Cancer Center-Belpre
Belpre, Ohio 45714
Belpre, Ohio 45714
Miami Valley Hospital South
Centerville, Ohio 45459
Centerville, Ohio 45459
Adena Regional Medical Center
Chillicothe, Ohio 45601
Chillicothe, Ohio 45601
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
Cincinnati, Ohio 45219
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
Cincinnati, Ohio 45220
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Columbus, Ohio 43210
Mount Carmel East Hospital
Columbus, Ohio 43213
Columbus, Ohio 43213
The Mark H Zangmeister Center
Columbus, Ohio 43219
Columbus, Ohio 43219
Premier Blood and Cancer Center
Dayton, Ohio 45409
Dayton, Ohio 45409
Contact:
Site Public Contact
937-276-8320
Site Public Contact
937-276-8320
Dayton Physician LLC - Englewood
Dayton, Ohio 45415
Dayton, Ohio 45415
Miami Valley Hospital North
Dayton, Ohio 45415
Dayton, Ohio 45415
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
Franklin, Ohio 45005-1066
Miami Valley Cancer Care and Infusion
Greenville, Ohio 45331
Greenville, Ohio 45331
Contact:
Site Public Contact
937-569-7515
Site Public Contact
937-569-7515
Mount Carmel Grove City Hospital
Grove City, Ohio 43123
Grove City, Ohio 43123
Kettering Medical Center
Kettering, Ohio 45429
Kettering, Ohio 45429
Fairfield Medical Center
Lancaster, Ohio 43130
Lancaster, Ohio 43130
Memorial Hospital
Marysville, Ohio 43040
Marysville, Ohio 43040
Summa Health Medina Medical Center
Medina, Ohio 44256
Medina, Ohio 44256
Licking Memorial Hospital
Newark, Ohio 43055
Newark, Ohio 43055
Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio 43551
Perrysburg, Ohio 43551
Southern Ohio Medical Center
Portsmouth, Ohio 45662
Portsmouth, Ohio 45662
Springfield Regional Cancer Center
Springfield, Ohio 45504
Springfield, Ohio 45504
ProMedica Flower Hospital
Sylvania, Ohio 43560
Sylvania, Ohio 43560
Mercy Health - Saint Anne Hospital
Toledo, Ohio 43623
Toledo, Ohio 43623
Upper Valley Medical Center
Troy, Ohio 45373
Troy, Ohio 45373
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
West Chester, Ohio 45069
Saint Ann's Hospital
Westerville, Ohio 43081
Westerville, Ohio 43081
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701
Zanesville, Ohio 43701
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
Oklahoma City, Oklahoma 73120
Contact:
Site Public Contact
405-752-3402
Site Public Contact
405-752-3402
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Three Rivers Community Hospital
Grants Pass, Oregon 97527
Grants Pass, Oregon 97527
Contact:
Site Public Contact
541-472-7000
Site Public Contact
541-472-7000
Legacy Mount Hood Medical Center
Gresham, Oregon 97030
Gresham, Oregon 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Asante Rogue Regional Medical Center
Medford, Oregon 97504
Medford, Oregon 97504
Providence Newberg Medical Center
Newberg, Oregon 97132
Newberg, Oregon 97132
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
Ontario, Oregon 97914
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
Oregon City, Oregon 97045
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
Portland, Oregon 97210
Providence Portland Medical Center
Portland, Oregon 97213
Portland, Oregon 97213
Providence Saint Vincent Medical Center
Portland, Oregon 97225
Portland, Oregon 97225
Kaiser Permanente Northwest
Portland, Oregon 97227
Portland, Oregon 97227
Legacy Meridian Park Hospital
Tualatin, Oregon 97062
Tualatin, Oregon 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
Allentown, Pennsylvania 18103
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017
Bethlehem, Pennsylvania 18017
Geisinger Medical Center
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
East Stroudsburg, Pennsylvania 18301
Saint Vincent Hospital
Erie, Pennsylvania 16544
Erie, Pennsylvania 16544
Contact:
Site Public Contact
814-452-5000
Site Public Contact
814-452-5000
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033-0850
Hershey, Pennsylvania 17033-0850
Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
Jefferson Hills, Pennsylvania 15025
Forbes Hospital
Monroeville, Pennsylvania 15146
Monroeville, Pennsylvania 15146
Contact:
Site Public Contact
412-858-7746
Site Public Contact
412-858-7746
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania 19114
Philadelphia, Pennsylvania 19114
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
Pittsburgh, Pennsylvania 15212
Contact:
Site Public Contact
877-284-2000
Site Public Contact
877-284-2000
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania 18840
Sayre, Pennsylvania 18840
Contact:
Site Public Contact
800-836-0388
Site Public Contact
800-836-0388
Community Medical Center
Scranton, Pennsylvania 18510
Scranton, Pennsylvania 18510
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
Wexford, Pennsylvania 15090
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
Wilkes-Barre, Pennsylvania 18711
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
Willow Grove, Pennsylvania 19090
Rhode Island Hospital
Providence, Rhode Island 02903
Providence, Rhode Island 02903
Contact:
Site Public Contact
401-444-1488
Site Public Contact
401-444-1488
Women and Infants Hospital
Providence, Rhode Island 02905
Providence, Rhode Island 02905
Contact:
Site Public Contact
401-274-1122
Site Public Contact
401-274-1122
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island 02891
Westerly, Rhode Island 02891
Saint Joseph's/Candler - Bluffton Campus
Bluffton, South Carolina 29910
Bluffton, South Carolina 29910
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina 29316
Boiling Springs, South Carolina 29316
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
Easley, South Carolina 29640
McLeod Regional Medical Center
Florence, South Carolina 29506
Florence, South Carolina 29506
Saint Francis Hospital
Greenville, South Carolina 29601
Greenville, South Carolina 29601
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Saint Francis Cancer Center
Greenville, South Carolina 29607
Greenville, South Carolina 29607
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
Greenville, South Carolina 29615
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
Greer, South Carolina 29650
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina 29926-3827
Hilton Head Island, South Carolina 29926-3827
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
Seneca, South Carolina 29672
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Avera Cancer Institute-Aberdeen
Aberdeen, South Dakota 57401
Aberdeen, South Dakota 57401
Avera Cancer Institute at Pierre
Pierre, South Dakota 57501
Pierre, South Dakota 57501
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Sioux Falls, South Dakota 57104
Avera Cancer Institute
Sioux Falls, South Dakota 57105
Sioux Falls, South Dakota 57105
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Sioux Falls, South Dakota 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
Collierville, Tennessee 38017
University of Tennessee - Knoxville
Knoxville, Tennessee 37920
Knoxville, Tennessee 37920
Contact:
Site Public Contact
865-544-9773
Site Public Contact
865-544-9773
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Memphis, Tennessee 38120
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee 37204
Nashville, Tennessee 37204
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
Nashville, Tennessee 37232
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Houston Methodist San Jacinto Hospital
Baytown, Texas 77521
Baytown, Texas 77521
MD Anderson in The Woodlands
Conroe, Texas 77384
Conroe, Texas 77384
Parkland Memorial Hospital
Dallas, Texas 75235
Dallas, Texas 75235
UT Southwestern Simmons Cancer Center - RedBird
Dallas, Texas 75237
Dallas, Texas 75237
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
Dallas, Texas 75390
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
Fort Worth, Texas 76104
Lyndon Baines Johnson General Hospital
Houston, Texas 77026-1967
Houston, Texas 77026-1967
Contact:
Site Public Contact
713-566-5000
Site Public Contact
713-566-5000
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas 77030
Houston, Texas 77030
Ben Taub General Hospital
Houston, Texas 77030
Houston, Texas 77030
Contact:
Site Public Contact
713-873-2000
Site Public Contact
713-873-2000
Houston Methodist Hospital
Houston, Texas 77030
Houston, Texas 77030
Contact:
Site Public Contact
713-790-2700
Site Public Contact
713-790-2700
M D Anderson Cancer Center
Houston, Texas 77030
Houston, Texas 77030
Methodist Willowbrook Hospital
Houston, Texas 77070
Houston, Texas 77070
MD Anderson West Houston
Houston, Texas 77079
Houston, Texas 77079
Houston Methodist West Hospital
Houston, Texas 77094
Houston, Texas 77094
Contact:
Site Public Contact
832-522-2873
Site Public Contact
832-522-2873
MD Anderson League City
League City, Texas 77573
League City, Texas 77573
Houston Methodist Saint John Hospital
Nassau Bay, Texas 77058
Nassau Bay, Texas 77058
UT Southwestern Clinical Center at Richardson/Plano
Richardson, Texas 75080
Richardson, Texas 75080
MD Anderson in Sugar Land
Sugar Land, Texas 77478
Sugar Land, Texas 77478
Houston Methodist Sugar Land Hospital
Sugar Land, Texas 77479
Sugar Land, Texas 77479
Contact:
Site Public Contact
281-242-2873
Site Public Contact
281-242-2873
Houston Methodist The Woodlands Hospital
The Woodlands, Texas 77385
The Woodlands, Texas 77385
University of Vermont Medical Center
Burlington, Vermont 05401
Burlington, Vermont 05401
Inova Schar Cancer Institute
Fairfax, Virginia 22031
Fairfax, Virginia 22031
Inova Fair Oaks Hospital
Fairfax, Virginia 22033
Fairfax, Virginia 22033
Inova Fairfax Hospital
Falls Church, Virginia 22042
Falls Church, Virginia 22042
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia 22939
Fishersville, Virginia 22939
Contact:
Site Public Contact
540-332-5960
Site Public Contact
540-332-5960
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
Mechanicsville, Virginia 23116
Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
Midlothian, Virginia 23114
Bon Secours Saint Mary's Hospital
Richmond, Virginia 23226
Richmond, Virginia 23226
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
Richmond, Virginia 23235
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
Richmond, Virginia 23298
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
Edmonds, Washington 98026
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
Issaquah, Washington 98029
Valley Medical Center
Renton, Washington 98055
Renton, Washington 98055
Fred Hutchinson Cancer Center
Seattle, Washington 98109
Seattle, Washington 98109
Contact:
Site Public Contact
800-804-8824
Site Public Contact
800-804-8824
Swedish Medical Center-First Hill
Seattle, Washington 98122
Seattle, Washington 98122
University of Washington Medical Center - Montlake
Seattle, Washington 98195
Seattle, Washington 98195
Contact:
Site Public Contact
800-804-8824
Site Public Contact
800-804-8824
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver, Washington 98684
Vancouver, Washington 98684
Legacy Salmon Creek Hospital
Vancouver, Washington 98686
Vancouver, Washington 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington 98902
Yakima, Washington 98902
Edwards Comprehensive Cancer Center
Huntington, West Virginia 25701
Huntington, West Virginia 25701
Camden Clark Medical Center
Parkersburg, West Virginia 26101
Parkersburg, West Virginia 26101
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Antigo, Wisconsin 54409
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
Appleton, Wisconsin 54911
Duluth Clinic Ashland
Ashland, Wisconsin 54806
Ashland, Wisconsin 54806
ThedaCare Cancer Care - Berlin
Berlin, Wisconsin 54923
Berlin, Wisconsin 54923
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
Burlington, Wisconsin 53105
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
Germantown, Wisconsin 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Grafton, Wisconsin 53024
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Green Bay, Wisconsin 54303
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Green Bay, Wisconsin 54311
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin 53548
Janesville, Wisconsin 53548
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek, Wisconsin 53038
Johnson Creek, Wisconsin 53038
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Kenosha, Wisconsin 53142
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin 53792
Madison, Wisconsin 53792
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
Marinette, Wisconsin 54143
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
Marshfield, Wisconsin 54449
Aspirus Medford Hospital
Medford, Wisconsin 54451
Medford, Wisconsin 54451
Froedtert Menomonee Falls Hospital
Menomonee Falls, Wisconsin 53051
Menomonee Falls, Wisconsin 53051
Contact:
Site Public Contact
262-257-5100
Site Public Contact
262-257-5100
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
Milwaukee, Wisconsin 53209
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Milwaukee, Wisconsin 53215
Medical College of Wisconsin
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
Contact:
Site Public Contact
414-805-3666
Site Public Contact
414-805-3666
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Milwaukee, Wisconsin 53233
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin 54548
Minocqua, Wisconsin 54548
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
Mukwonago, Wisconsin 53149
ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin 54956
Neenah, Wisconsin 54956
ThedaCare Cancer Care - New London
New London, Wisconsin 54961
New London, Wisconsin 54961
Drexel Town Square Health Center
Oak Creek, Wisconsin 53154
Oak Creek, Wisconsin 53154
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Oconomowoc, Wisconsin 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
Oconto Falls, Wisconsin 54154
ThedaCare Cancer Care - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
Racine, Wisconsin 53406
Ascension Saint Mary's Hospital
Rhinelander, Wisconsin 54501
Rhinelander, Wisconsin 54501
ThedaCare Cancer Care - Shawano
Shawano, Wisconsin 54166
Shawano, Wisconsin 54166
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Ascension Saint Michael's Hospital
Stevens Point, Wisconsin 54481
Stevens Point, Wisconsin 54481
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
Stevens Point, Wisconsin 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
Sturgeon Bay, Wisconsin 54235-1495
Aurora Medical Center in Summit
Summit, Wisconsin 53066
Summit, Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Two Rivers, Wisconsin 54241
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Waukesha, Wisconsin 53188
ThedaCare Cancer Care - Waupaca
Waupaca, Wisconsin 54981
Waupaca, Wisconsin 54981
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Wausau, Wisconsin 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
Wauwatosa, Wisconsin 53226
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
West Allis, Wisconsin 53227
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend, Wisconsin 53095
West Bend, Wisconsin 53095
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
Marshfield Medical Center - Weston
Weston, Wisconsin 54476
Weston, Wisconsin 54476
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494
Wisconsin Rapids, Wisconsin 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
Doctors Cancer Center
Manati, Puerto Rico 00674
Manati, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397
Site Public Contact
787-621-4397
PROncology
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
San Juan City Hospital
San Juan, Puerto Rico 00936
San Juan, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296
Site Public Contact
787-763-1296
More Details
- NCT ID
- NCT05812807
- Status
- Recruiting
- Sponsor
- Alliance for Clinical Trials in Oncology
Detailed Description
PRIMARY OBJECTIVES: I. To evaluate whether observation results in a non-inferior recurrence-free survival (RFS) compared to adjuvant pembrolizumab in early-stage triple-negative breast cancer (TNBC) patients who achieve a pathologic complete response (pCR) after neoadjuvant chemotherapy with pembrolizumab. II. To compare quality of life (QOL) at approximately 27 weeks as assessed by the Functional Assessment of Cancer Therapy-Breast (FACT-B) Trial Outcome Index between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) III. To assess the social value of de-escalation of adjuvant breast cancer immunotherapy at approximately 27 weeks and, by modeling, over a lifetime. (Value of Care) SECONDARY OBJECTIVES: I. To evaluate whether observation compared to adjuvant pembrolizumab impacts the following: Ia. RFS by stage at presentation and by receipt of prior anthracycline therapy; Ib. Adverse event rate: difference in Grade 3 or higher adverse event rates overall and Grade 3 or higher immune-related adverse events (irAEs) rates; Ic. Overall Survival (OS); Id. Locoregional recurrence (LRR both isolated LRR as first events and LRR events simultaneous with DM); Ie. RFS, LRR, OS, adverse events, and QOL by age (=< 45, 46-65, and > 65), race, and ethnicity; If. Adverse events related to receipt of radiotherapy. II. To assess the value of de-escalation of breast cancer immunotherapy from the payer perspective at approximately 27 weeks and, by modelling, over a lifetime. (Value of Care) III. To compare patient out-of-pocket costs at approximately 27 weeks between patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) IV. To compare financial toxicity at approximately 27 weeks between patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) V. To compare work/productivity impairment at approximately 27 weeks between patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) EXPLORATORY OBJECTIVES: I. To describe trajectories of QOL over time among patients randomized to adjuvant pembrolizumab versus (vs.) observation. (Quality of Life) II. To compare various QOL domains after approximately 27 weeks as assessed by the 5 subscales of the FACT-B Index between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) III. To compare self-reported symptomatic adverse events at approximately 27 weeks assessed by the patient reported outcome Common Terminology Criteria for Adverse Events (PRO-CTCAE) between patients randomized to adjuvant pembrolizumab versus observation. (Quality of Life) IV. To describe trajectories of financial toxicity and work/productivity impairment over time from baseline to approximately 27 weeks among patients randomized to adjuvant pembrolizumab versus observation. (Value of Care) V. To develop and assess a measure of value from the patient perspective at approximately 27 weeks. (Value of Care) OUTLINE: Patients are randomized to 1 of 2 arms after completing neoadjuvant chemotherapy in combination with pembrolizumab, followed by definitive breast surgery. ARM I (PEMBROLIZUMAB): Patients receive pembrolizumab intravenously (IV) on study. Patients also undergo tumor biopsy on study, and collection of blood on study and during follow-up. ARM II (OBSERVATION): Patients undergo observation on study. Patients also undergo tumor biopsy on study, and collection of blood on study and during follow-up.