Shorter Chemo-Immunotherapy Without Anthracycline Drugs for Early-Stage Triple Negative Breast Cancer

Purpose

This phase III trial compares the effects of shorter chemotherapy (chemo)-immunotherapy without anthracyclines to usual chemo-immunotherapy for the treatment of early-stage triple negative breast cancer. Paclitaxel is in a class of medications called anti-microtubule agents. It stops cancer cells from growing and dividing and may kill them. Carboplatin is in a class of medications known as platinum-containing compounds. It works in a way similar to the anticancer drug cisplatin, but may be better tolerated than cisplatin. Carboplatin works by killing, stopping or slowing the growth of cancer cells. Cyclophosphamide is in a class of medications called alkylating agents. It works by damaging the cell's deoxyribonucleic acid (DNA) and may kill cancer cells. It may also lower the body's immune response. Docetaxel is in a class of medications called taxanes. It stops cancer cells from growing and dividing and may kill them. Doxorubicin is an anthracycline chemotherapy drug that damages DNA and may kill cancer cells. Pembrolizumab may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Shorter treatment without anthracycline chemotherapy may work the same as the usual anthracycline chemotherapy treatment for early-stage triple negative breast cancer.

Conditions

  • Anatomic Stage I Breast Cancer AJCC v8
  • Anatomic Stage II Breast Cancer AJCC v8
  • Anatomic Stage IIIA Breast Cancer AJCC v8
  • Anatomic Stage IIIB Breast Cancer AJCC v8
  • Early Stage Triple-Negative Breast Carcinoma

Eligibility

Eligible Ages
Over 18 Years
Eligible Sex
All
Accepts Healthy Volunteers
No

Criteria

Inclusion Criteria:

- Participants must have histologically confirmed estrogen receptor (ER)-negative,
progesterone receptor (PR)-negative, and HER2-negative breast cancer (TNBC) defined
as ER < 5%, PR < 5%, and HER2 negative (per 2020 American Society of Clinical
Oncology [ASCO] College of American Pathologists [CAP] guidelines)

- NOTE: Participants with weakly ER or PR positive disease, defined as ER and/or
PR between 1-4% by immunohistochemistry, are eligible if adjuvant endocrine
therapy is not recommended/planned by the treating physician

- Participants must have American Joint Committee on Cancer (AJCC) 8 anatomic tumor
clinical stage either

- T2-T4, N0, M0 or

- T1-T3, N1-2, M0

- Note: All participants with clinically suspicious nodes must undergo core
needle biopsy or fine needle biopsy per standard clinical practice to
pathologically confirm nodal status

- Participants must have breast and axillary imaging with mammogram and/or ultrasound
and/or magnetic resonance imaging (MRI) within 49 days prior to randomization

- Note: Participants with bilateral invasive breast cancer are eligible if both
breast cancers are ER-negative, PR-negative, and HER2-negative provided they
meet the other eligibility criteria

- Participants must not have T4/N+, any N3, or inflammatory breast cancer

- Participants must not have metastatic disease (M1)

- Participants must not have received prior systemic therapy or radiation therapy with
curative intent for the current breast cancer

- Participants must not have had previous definitive ipsilateral breast surgery for
the current breast cancer

- Participants must not have current or anticipated use of other investigational
agents while participating in this study

- Participants must not have history of allergic reactions attributed to compounds of
similar chemical or biologic composition as study agents

- Participants must not have severe hypersensitivity (>= grade 3) to pembrolizumab or
any of its excipients

- Participants must not have received prior therapy with an anti-PD-1, anti-PD-L1, or
anti-PD-L2 agent or with an agent directed to another stimulatory or co-inhibitory
T-cell receptor (e.g. CTLA-4, OX-40, CD137)

- Participants must not be currently participating in or have participated in a study
of an investigational agent or used an investigational device within 28 days prior
to randomization

- Participants must be >= 18 years old

- Participants must have Zubrod performance status of 0-2

- Participants with evidence of peripheral neuropathy must have it at =< grade 1, by
Common Terminology Criteria for Adverse Events (CTCAE) version (v.) 5.0, within 28
days prior to randomization

- Participants must have a complete medical history and physical exam within 28 days
prior to randomization

- Hemoglobin >= 9.0 g/dL or >= 5.6 mol/L (within 28 days prior to randomization)

- (Criteria must be met without erythropoietin dependency and without packed red
blood cell transfusion within last 2 weeks)

- Leukocytes >= 3 x 10^3/uL (within 28 days prior to randomization)

- Absolute neutrophil count >= 1.5 x 10^3/uL (within 28 days prior to randomization)

- Platelets >= 100 x 10^3/uL (within 28 days prior to randomization)

- Total bilirubin =< 1.5 x institutional upper limit of normal (IULN), OR direct
bilirubin =< IULN for participants with total bilirubin > 1.5 x IULN (unless history
of Gilbert's disease. Participants with history of Gilbert's disease must have total
bilirubin =< 5 x institutional IULN) (within 28 days prior to randomization)

- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 3 x
institutional upper limit of normal (ULN) (within 28 days prior to randomization)

- Participants must have a serum creatinine =< the IULN OR calculated creatinine
clearance >= 50 mL/min/1.73m^2 using the following Cockcroft-Gault Formula. This
specimen must have been drawn and processed within 28 days prior to registration

- Participants must have adequate cardiac function. Participants must have left
ventricular ejection fraction >= 50% as assessed by either echocardiography (ECHO)
or multigated acquisition scan (MUGA) assessed within 28 days prior to registration.
Participants with known history or current symptoms of cardiac disease, or history
of treatment with cardiotoxic agents, must have a clinical risk assessment of
cardiac function using the New York Heart Association Functional Classification and
must be class 2B or better

- Participants with known human immunodeficiency virus (HIV)-infection must be on
effective anti-retroviral therapy at randomization and have undetectable viral load
test on the most recent test results obtained within 6 months prior to randomization

- Participants with evidence of chronic hepatitis B virus (HBV) infection must have
undetectable HBV viral load while on suppressive therapy on the most recent test
results obtained within 6 months prior to randomization, if indicated

- Note: No testing for Hepatitis B is required unless mandated by local health
authority

- Participants with a history of hepatitis C virus (HCV) infection must have been
treated and cured. Participants currently being treated for HCV infection must have
undetectable HCV viral load test on the most recent test results obtained within 6
months prior to randomization, if indicated

- Note: No testing for hepatitis C is required unless mandated by local health
authority

- Participants with history of diabetes must not have uncontrolled diabetes in the
opinion of the treating investigator

- Participants must not have uncontrolled hypertension in the opinion of the treating
investigator

- Participants must not have had a major surgery within 14 days prior to
randomization. Participants must have fully recovered from the effects of prior
major surgery in the opinion of the treating investigator

- Participants must not have severe or active infections within 14 days prior to
Randomization, including but not limited to hospitalization for infection,
bacteremia, or severe pneumonia

- Participants must not have a diagnosis of immunodeficiency and be receiving chronic
systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent)
or any other form of immunosuppressive therapy within 7 days prior to randomization

- Participants must not have active autoimmune disease that has required systemic
treatment in 2 years prior to randomization (i.e., with use of disease modifying
agents, corticosteroids or immunosuppressive drugs). Replacement therapy (e.g.,
thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or
pituitary insufficiency) is not considered a form of systemic treatment

- Participants must not have a history of (non-infectious) pneumonitis that required
steroids, or has current (non-infectious) pneumonitis

- Participants must not have received a live vaccine within 30 days prior to
randomization. Examples of live vaccines include, but are not limited to, the
following: measles, mumps, rubella, varicella/zoster (chicken pox), yellow fever,
rabies, Bacillus Calmette-Guerin (BCG), and typhoid vaccine. Seasonal influenza
vaccines for injection are generally killed virus vaccines and are allowed; however,
intranasal influenza vaccines (e.g., FluMist [registered trademark]) are live
attenuated vaccines and are not allowed

- Participants must not have a prior or concurrent malignancy whose natural history or
treatment (in the opinion of the treating physician) has the potential to interfere
with the safety or efficacy assessment of the treatment regimen

- Participants must not be pregnant or nursing. Individuals who are of reproductive
potential must have agreed to use an effective contraceptive method with details
provided as a part of the consent process. A person who has had menses at any time
in the preceding 12 consecutive months or who has semen likely to contain sperm is
considered to be of "reproductive potential." In addition to routine contraceptive
methods, "effective contraception" also includes refraining from sexual activity
that might result in pregnancy and surgery intended to prevent pregnancy (or with a
side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy,
bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in
the semen

- Participants must have one (1) physical 4-5-micron single hematoxylin and eosin
(H&E) slide from the archival pretreatment diagnostic biopsy available for
submission

- Participants must be offered the opportunity to participate in specimen banking.
With participant consent, specimens must be collected and submitted via the
Southwest Oncology Group (SWOG) Specimen Tracking System

- Participants who can complete questionnaires in English, Spanish, or French must be
offered the opportunity to participate in the Patient-Reported Outcome study

- NOTE: As a part of the Oncology Patient Enrollment Network (OPEN) registration
process the treating institution's identity is provided in order to ensure that the
current (within 365 days) date of institutional review board approval for this study
has been entered in the system

- Participants must be informed of the investigational nature of this study and
must sign and give informed consent in accordance with institutional and
federal guidelines

- For participants with impaired decision-making capabilities, legally authorized
representatives may sign and give informed consent on behalf of study
participants in accordance with applicable federal, local, and Central
Institutional Review Board (CIRB) regulations

- As part of the registration process the treating institution's identity is provided
in order to ensure that the current (within 365 days) date of institutional review
board approval for this study has been entered in the system

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Arm I (usual chemo-immunotherapy)
Patients receive paclitaxel IV, carboplatin IV, and pembrolizumab IV on study. Patients then receive doxorubicin IV, cyclophosphamide IV, and pembrolizumab IV on study. Patients then undergo surgery. Patients may receive pembrolizumab after surgery. Patients may optionally undergo collection of blood samples throughout the trial.
  • Procedure: Biospecimen Collection
    Undergo collection of blood samples
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Drug: Carboplatin
    Given IV
    Other names:
    • Blastocarb
    • Carboplat
    • Carboplatin Hexal
    • Carboplatino
    • Carboplatinum
    • Carbosin
    • Carbosol
    • Carbotec
    • CBDCA
    • Displata
    • Ercar
    • JM-8
    • Nealorin
    • Novoplatinum
    • Paraplatin
    • Paraplatin AQ
    • Paraplatine
    • Platinwas
    • Ribocarbo
  • Drug: Cyclophosphamide
    Given IV
    Other names:
    • (-)-Cyclophosphamide
    • 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate
    • Carloxan
    • Ciclofosfamida
    • Ciclofosfamide
    • Cicloxal
    • Clafen
    • Claphene
    • CP monohydrate
    • CTX
    • CYCLO-cell
    • Cycloblastin
    • Cycloblastine
    • Cyclophospham
    • Cyclophosphamid monohydrate
    • Cyclophosphamide Monohydrate
    • Cyclophosphamidum
    • Cyclophosphan
    • Cyclophosphane
    • Cyclophosphanum
    • Cyclostin
    • Cyclostine
    • Cytophosphan
    • Cytophosphane
    • Cytoxan
    • Fosfaseron
    • Genoxal
    • Genuxal
    • Ledoxina
    • Mitoxan
    • Neosar
    • Revimmune
    • Syklofosfamid
    • WR- 138719
  • Drug: Doxorubicin
    Given IV
    Other names:
    • Adriablastin
    • Hydroxydaunomycin
    • Hydroxyl Daunorubicin
    • Hydroxyldaunorubicin
  • Drug: Paclitaxel
    Given IV
    Other names:
    • Anzatax
    • Asotax
    • Bristaxol
    • Praxel
    • Taxol
    • Taxol Konzentrat
  • Biological: Pembrolizumab
    Given IV
    Other names:
    • Keytruda
    • Lambrolizumab
    • MK-3475
    • SCH 900475
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Procedure: Surgical Procedure
    Undergo surgery
    Other names:
    • Operation
    • Surgery
    • Surgery Type
    • Surgery, NOS
    • Surgical
    • Surgical Intervention
    • Surgical Interventions
    • Surgical Procedures
    • Type of Surgery
Experimental
Arm II (shorter chemo-immunotherapy)
Patients receive docetaxel IV, carboplatin IV, and pembrolizumab IV on study. Patients then undergo surgery. Patients may receive pembrolizumab after surgery. Patients may optionally undergo collection of blood samples throughout the trial.
  • Procedure: Biospecimen Collection
    Undergo collection of blood samples
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Drug: Carboplatin
    Given IV
    Other names:
    • Blastocarb
    • Carboplat
    • Carboplatin Hexal
    • Carboplatino
    • Carboplatinum
    • Carbosin
    • Carbosol
    • Carbotec
    • CBDCA
    • Displata
    • Ercar
    • JM-8
    • Nealorin
    • Novoplatinum
    • Paraplatin
    • Paraplatin AQ
    • Paraplatine
    • Platinwas
    • Ribocarbo
  • Drug: Docetaxel
    Given IV
    Other names:
    • Docecad
    • RP56976
    • Taxotere
    • Taxotere Injection Concentrate
  • Biological: Pembrolizumab
    Given IV
    Other names:
    • Keytruda
    • Lambrolizumab
    • MK-3475
    • SCH 900475
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Procedure: Surgical Procedure
    Undergo surgery
    Other names:
    • Operation
    • Surgery
    • Surgery Type
    • Surgery, NOS
    • Surgical
    • Surgical Intervention
    • Surgical Interventions
    • Surgical Procedures
    • Type of Surgery

Recruiting Locations

Anchorage Associates in Radiation Medicine
Anchorage 5879400, Alaska 5879092 98508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Anchorage Radiation Therapy Center
Anchorage 5879400, Alaska 5879092 99504
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Breast Care and Surgery LLC
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Oncology and Hematology LLC
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Women's Cancer Care
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Anchorage Oncology Centre
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Katmai Oncology Group
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Cancer Center at Saint Joseph's
Phoenix 5308655, Arizona 5551752 85004
Contact:
Site Public Contact
602-406-0777
Research-cancerinstitute@dignityhealth.org

Mercy Hospital Fort Smith
Fort Smith 4111410, Arkansas 4099753 72903
Contact:
Site Public Contact
800-378-9373

NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Contact:
Site Public Contact
870-936-7066
Emily.Carvell@bmhcc.org

CARTI Cancer Center
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-906-4199
Research@CARTI.com

Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande 5324802, California 5332921 93420
Contact:
Site Public Contact
805-219-4673
ResearchInstituteInquiries@CommonSpirit.org

Sutter Auburn Faith Hospital
Auburn 5325223, California 5332921 95602
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn 5325223, California 5332921 95603
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Alta Bates Summit Medical Center-Herrick Campus
Berkeley 5327684, California 5332921 94704
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Tower Cancer Research Foundation
Beverly Hills 5328041, California 5332921 90211
Contact:
Site Public Contact
towercancerresearch@toweroncology.com

Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank 5331835, California 5332921 91505
Contact:
Site Public Contact
818-847-4793
Najee.Boucher@providence.org

Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park 5333282, California 5332921 95682
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Mercy Cancer Center �� Carmichael
Carmichael 5334336, California 5332921 95608
Contact:
Site Public Contact
protocols@swog.org

Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Contact:
Site Public Contact
916-556-3301
OncologyResearch@DignityHealth.org

Eden Hospital Medical Center
Castro Valley 5334928, California 5332921 94546
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Sutter Davis Hospital
Davis 5341704, California 5332921 95616
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Contact:
Site Public Contact
916-556-3301
OncologyResearch@DignityHealth.org

Palo Alto Medical Foundation-Fremont
Fremont 5350734, California 5332921 94538
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965

Memorial Medical Center
Modesto 5373900, California 5332921 95355
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Palo Alto Medical Foundation-Camino Division
Mountain View 5375480, California 5332921 94040
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View 5375480, California 5332921 94040
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Providence Queen of The Valley
Napa 5376095, California 5332921 94558
Contact:
Site Public Contact
707-521-3830

Sutter Cancer Research Consortium
Novato 5378044, California 5332921 94945
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Desert Regional Medical Center
Palm Springs 5380668, California 5332921 92262
Contact:
Site Public Contact
760-416-4730

Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Contact:
Site Public Contact
916-556-3301
OncologyResearch@DignityHealth.org

Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Sutter Roseville Medical Center
Roseville 5388881, California 5332921 95661
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Contact:
Site Public Contact
916-556-3301
OncologyResearch@DignityHealth.org

Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

California Pacific Medical Center-Pacific Campus
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo 5392323, California 5332921 93401
Contact:
Site Public Contact
805-219-4673
ResearchInstituteInquiries@CommonSpirit.org

Mills Health Center
San Mateo 5392423, California 5332921 94401
Contact:
Site Public Contact
protocols@swog.org

Palo Alto Medical Foundation-Santa Cruz
Santa Cruz 5393052, California 5332921 95065
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Mission Hope Medical Oncology - Santa Maria
Santa Maria 5393180, California 5332921 93444
Contact:
Site Public Contact
805-219-4673
ResearchInstituteInquiries@CommonSpirit.org

Providence Medical Foundation - Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
707-521-3830

Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
415-209-2683
hempell@sutterhealth.org

Providence Santa Rosa Memorial Hospital
Santa Rosa 5393287, California 5332921 95405
Contact:
Site Public Contact
707-521-3830

Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Cedars-Sinai Cancer - Tarzana
Tarzana 5401143, California 5332921 91356
Contact:
Site Public Contact
818-981-3818

Torrance Memorial Physician Network - Cancer Care
Torrance 5403022, California 5332921 90505
Contact:
Site Public Contact
310-750-3300
courtney.steeneken@tmphysicians.com

Sutter Solano Medical Center/Cancer Center
Vallejo 5405380, California 5332921 94589
Contact:
Site Public Contact
Melanie.Cook@sutterhealth.org

Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Contact:
Site Public Contact
916-556-3301
OncologyResearch@DignityHealth.org

Penrose-Saint Francis Healthcare
Colorado Springs 5417598, Colorado 5417618 80907
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618 80907
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Saint Francis Cancer Center
Colorado Springs 5417598, Colorado 5417618 80923
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

National Jewish Health-Main Campus
Denver 5419384, Colorado 5417618 80206
Contact:
Site Public Contact
877-225-5654
glicht@co-cancerresearch.org

Porter Adventist Hospital
Denver 5419384, Colorado 5417618 80210
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

SCL Health Saint Joseph Hospital
Denver 5419384, Colorado 5417618 80218
Contact:
Site Public Contact
303-318-3413
alan.franklin@sclhealth.org

Mercy Medical Center
Durango 5420241, Colorado 5417618 81301
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Southwest Oncology PC
Durango 5420241, Colorado 5417618 81301
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

National Jewish Health-Western Hematology Oncology
Golden 5423294, Colorado 5417618 80401
Contact:
Site Public Contact
303-777-2663
glicht@co-cancerresearch.org

SCL Health Cancer Centers of Colorado - Lutheran Medical Center
Golden 5423294, Colorado 5417618 80401
Contact:
Site Public Contact
303-813-5225
Alan.miller@sclhealth.org

Saint Anthony Hospital
Lakewood 5427946, Colorado 5417618 80228
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Littleton Adventist Hospital
Littleton 5429032, Colorado 5417618 80122
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Longmont United Hospital
Longmont 5579276, Colorado 5417618 80501
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Parker Adventist Hospital
Parker 5434006, Colorado 5417618 80138
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

Saint Mary Corwin Medical Center
Pueblo 5435464, Colorado 5417618 81004
Contact:
Site Public Contact
719-776-6550
ResearchTracking@Centura.Org

National Jewish Health-Northern Hematology Oncology
Thornton 5441492, Colorado 5417618 80260
Contact:
Site Public Contact
303-777-2663
glicht@co-cancerresearch.org

SCL Health Lutheran Medical Center
Wheat Ridge 5443948, Colorado 5417618 80033
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Beebe South Coastal Health Campus
Frankford 4142601, Delaware 4142224 19945
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Beebe Medical Center
Lewes 4143354, Delaware 4142224 19958
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Delaware Clinical and Laboratory Physicians PA
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
mhayden@christianacare.org

Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224 19718
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Contact:
Site Public Contact
302-291-6730
research@beebehealthcare.org

Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224 19801
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

The Watson Clinic
Lakeland 4161438, Florida 4155751 33805
Contact:
Site Public Contact
863-680-7780

Lewis Hall Singletary Oncology Center
Thomasville 4226348, Georgia 4197000 31792
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Saint Alphonsus Cancer Care Center-Boise
Boise 5586437, Idaho 5596512 83706
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell 5587698, Idaho 5596512 83605
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Kootenai Health - Coeur d'Alene
Coeur d'Alene 5589173, Idaho 5596512 83814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Walter Knox Memorial Hospital
Emmett 5592562, Idaho 5596512 83617
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Idaho Urologic Institute-Meridian
Meridian 5600685, Idaho 5596512 83642
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83686
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Alphonsus Cancer Care Center-Nampa
Nampa 5601933, Idaho 5596512 83687
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kootenai Clinic Cancer Services - Post Falls
Post Falls 5604353, Idaho 5596512 83854
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kootenai Cancer Clinic
Sandpoint 5606401, Idaho 5596512 83864
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Anthony's Health
Alton 4232679, Illinois 4896861 62002
Contact:
Site Public Contact
618-463-5623

Rush - Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Memorial Hospital of Carbondale
Carbondale 4235193, Illinois 4896861 62902
Contact:
Site Public Contact
618-457-5200
clinical.research@sih.net

SIH Cancer Institute
Carterville 4235311, Illinois 4896861 62918
Contact:
Site Public Contact
618-985-3333
clinical.research@sih.net

Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Saint Mary's Hospital
Centralia 4235587, Illinois 4896861 62801
Contact:
Site Public Contact
protocols@swog.org

Northwestern University
Chicago 4887398, Illinois 4896861 60611
Contact:
Site Public Contact
312-695-1301
cancer@northwestern.edu

Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800

Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Western Illinois Cancer Treatment Center
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-344-2831

Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861 60045
Contact:
Site Public Contact
cancertrials@northwestern.edu

Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Good Samaritan Regional Health Center
Mount Vernon 4245152, Illinois 4896861 62864
Contact:
Site Public Contact
618-242-4600

Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
Contact:
Site Public Contact
217-876-4762
morganthaler.jodi@mhsil.com

Northwestern Medicine Orland Park
Orland Park 4904937, Illinois 4896861 60462
Contact:
Site Public Contact
nctnprogram_rhlccc@northwestern.edu

Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Valley Radiation Oncology
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
815-664-4141

Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

SwedishAmerican Regional Cancer Center/ACT
Rockford 4907959, Illinois 4896861 61114
Contact:
Site Public Contact
779-696-9378
lkline@uwhealth.org

Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929

Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541

Memorial Medical Center
Springfield 4250542, Illinois 4896861 62781
Contact:
Site Public Contact
217-528-7541
pallante.beth@mhsil.com

Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Rush-Copley Healthcare Center
Yorkville 4917298, Illinois 4896861 60560
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Reid Health
Richmond 4263681, Indiana 4921868 47374
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673

Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690

Medical Oncology and Hematology Associates-West Des Moines
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305

Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-358-6613
cancerresearch@mercydesmoines.org

Alegent Health Mercy Hospital
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
402-717-1510
ResearchInstituteInquiries@CommonSpirit.org

Greater Regional Medical Center
Creston 4853078, Iowa 4862182 50801
Contact:
Site Public Contact
515-358-6613
cancerresearch@mercydesmoines.org

Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-358-6613
cancerresearch@mercydesmoines.org

Mission Cancer and Blood - Laurel
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305

Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182 50266
Contact:
Site Public Contact
515-358-6613
cancerresearch@mercydesmoines.org

Cancer Center of Kansas - Chanute
Chanute 4269392, Kansas 4273857 66720
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - Dodge City
Dodge City 5445298, Kansas 4273857 67801
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - El Dorado
El Dorado 4270863, Kansas 4273857 67042
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Central Care Cancer Center - Garden City
Garden City 5445439, Kansas 4273857 67846
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

Central Care Cancer Center - Great Bend
Great Bend 4272340, Kansas 4273857 67530
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

HaysMed University of Kansas Health System
Hays 4272782, Kansas 4273857 67601
Contact:
Site Public Contact
785-623-5774

Cancer Center of Kansas-Independence
Independence 4273359, Kansas 4273857 67301
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas-Kingman
Kingman 4273978, Kansas 4273857 67068
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Lawrence Memorial Hospital
Lawrence 4274277, Kansas 4273857 66044
Contact:
Site Public Contact
785-505-2800
Stephanie.Norris@LMH.ORG

Cancer Center of Kansas-Liberal
Liberal 5445820, Kansas 4273857 67905
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas-Manhattan
Manhattan 4274994, Kansas 4273857 66502
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - McPherson
McPherson 4275261, Kansas 4273857 67460
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - Newton
Newton 4276248, Kansas 4273857 67114
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Olathe Health Cancer Center
Olathe 4276614, Kansas 4273857 66061
Contact:
Site Public Contact
913-355-8000
Jeni.wakefield@olathehealth.org

Cancer Center of Kansas - Parsons
Parsons 4277011, Kansas 4273857 67357
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - Pratt
Pratt 4277752, Kansas 4273857 67124
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - Salina
Salina 4278890, Kansas 4273857 67401
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Contact:
Site Public Contact
785-452-7038
mleepers@srhc.com

University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000

Cancer Center of Kansas - Wellington
Wellington 4281386, Kansas 4273857 67152
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita 4281730, Kansas 4273857 67208
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - Wichita
Wichita 4281730, Kansas 4273857 67214
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Cancer Center of Kansas - Winfield
Winfield 4281897, Kansas 4273857 67156
Contact:
Site Public Contact
316-291-4774
research@viachristi.org

Flaget Memorial Hospital
Bardstown 4283133, Kentucky 6254925 40004
Contact:
Site Public Contact
859-629-7169
ResearchInstituteInquiries@CommonSpirit.org

Commonwealth Cancer Center-Corbin
Corbin 4288656, Kentucky 6254925 40701
Contact:
Site Public Contact
859-629-7169
ResearchInstituteInquiries@CommonSpirit.org

Saint Joseph Hospital
Lexington 4297983, Kentucky 6254925 40504
Contact:
Site Public Contact
protocols@swog.org

Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925 40504
Contact:
Site Public Contact
859-629-7169
ResearchInstituteInquiries@CommonSpirit.org

Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925 40509
Contact:
Site Public Contact
859-629-7169
ResearchInstituteInquiries@CommonSpirit.org

Saint Joseph London
London 4298960, Kentucky 6254925 40741
Contact:
Site Public Contact
859-629-7169
ResearchInstituteInquiries@CommonSpirit.org

Saint Joseph Mount Sterling
Mount Sterling 4301683, Kentucky 6254925 40353
Contact:
Site Public Contact
protocols@swog.org

Louisiana State University Health Science Center
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Christiana Care - Union Hospital
Elkton 4354234, Maryland 4361885 21921
Contact:
Site Public Contact
410-620-3710
sstewart@uhcc.com

Beverly Hospital
Beverly 4930505, Massachusetts 6254926 01915
Contact:
Site Public Contact
978-922-3000

Lahey Hospital and Medical Center
Burlington 4931737, Massachusetts 6254926 01805
Contact:
Site Public Contact
781-744-3421
lhmc-cancer-clinical-trials@lahey.org

Addison Gilbert Hospital
Gloucester 4937829, Massachusetts 6254926 01930
Contact:
Site Public Contact
978-283-4000

Lahey Medical Center-Peabody
Peabody 4946863, Massachusetts 6254926 01960
Contact:
Site Public Contact
781-744-3421
lhmc-cancer-clinical-trials@lahey.org

Winchester Hospital
Winchester 4955884, Massachusetts 6254926 01890
Contact:
Site Public Contact
protocols@swog.org

Hickman Cancer Center
Adrian 4983811, Michigan 5001836 49221
Contact:
Site Public Contact
517-265-0116

Saint Joseph Mercy Hospital
Ann Arbor 4984247, Michigan 5001836 48106
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Saint Joseph Mercy Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Saint Joseph Mercy Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Caro Cancer Center
Caro 4988059, Michigan 5001836 48723
Contact:
Site Public Contact
989-907-8411
lori.srebinski@ascension.org

Saint Joseph Mercy Chelsea
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Hematology Oncology Consultants-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Newland Medical Associates-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Beaumont Hospital - Dearborn
Dearborn 4990510, Michigan 5001836 48124
Contact:
Site Public Contact
248-551-7695

Ascension Saint John Hospital
Detroit 4990729, Michigan 5001836 48236
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan 5001836 48054
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Beaumont Hospital - Farmington Hills
Farmington Hills 4992523, Michigan 5001836 48336
Contact:
Site Public Contact
248-551-7695

Genesee Cancer and Blood Disease Treatment Center
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

Genesee Hematology Oncology PC
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

Hurley Medical Center
Flint 4992982, Michigan 5001836 48503
Contact:
Site Public Contact
810-762-8038
wstrong@ghci.org

Academic Hematology Oncology Specialists
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Sparrow Hospital
Lansing 4998830, Michigan 5001836 48912
Contact:
Site Public Contact
517-364-9400

Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb 5000473, Michigan 5001836 48044
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Saint Mary's Oncology/Hematology Associates of Marlette
Marlette 5000938, Michigan 5001836 48453
Contact:
Site Public Contact
989-907-8411
lori.srebinski@ascension.org

Toledo Clinic Cancer Centers-Monroe
Monroe 5002344, Michigan 5001836 48162
Contact:
Site Public Contact
800-444-3561

21st Century Oncology-Pontiac
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Hope Cancer Center
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Newland Medical Associates-Pontiac
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Saint Joseph Mercy Oakland
Pontiac 5006166, Michigan 5001836 48341
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Oakland Colon Rectal Associates
Royal Oak 5007804, Michigan 5001836 48067
Contact:
Site Public Contact
248-551-7695

Cancer Care Associates PC
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Comprehensive Medical Center PLLC
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Hematology Oncology Consultants PC
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Oakland Medical Group
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

William Beaumont Hospital-Royal Oak
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Ascension Saint Mary's Hospital
Saginaw 5007989, Michigan 5001836 48601
Contact:
Site Public Contact
989-907-8411
lori.srebinski@ascension.org

Oncology Hematology Associates of Saginaw Valley PC
Saginaw 5007989, Michigan 5001836 48604
Contact:
Site Public Contact
989-907-8411
lori.srebinski@ascension.org

Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights 5011148, Michigan 5001836 48312
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Premier Hematology Oncology Care
Sterling Heights 5011148, Michigan 5001836 48312
Contact:
Site Public Contact
248-551-7695

Ascension Saint Joseph Hospital
Tawas City 5011900, Michigan 5001836 48764
Contact:
Site Public Contact
989-907-8411
lori.srebinski@ascension.org

Michigan Institute of Urology-Town Center
Troy 5012639, Michigan 5001836 48084
Contact:
Site Public Contact
248-551-7695

William Beaumont Hospital - Troy
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695

Hematology Oncology Consultants PC-Troy
Troy 5012639, Michigan 5001836 48098
Contact:
Site Public Contact
248-551-7695

Advanced Breast Care Center PLLC
Warren 5014051, Michigan 5001836 48088
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren 5014051, Michigan 5001836 48093
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Macomb Hematology Oncology PC
Warren 5014051, Michigan 5001836 48093
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Michigan Breast Specialists-Warren
Warren 5014051, Michigan 5001836 48093
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Saint John Macomb-Oakland Hospital
Warren 5014051, Michigan 5001836 48093
Contact:
Site Public Contact
313-343-3166
karen.forman@ascension.org

Saint Mary's Oncology/Hematology Associates of West Branch
West Branch 5014413, Michigan 5001836 48661
Contact:
Site Public Contact
989-907-8411
lori.srebinski@ascension.org

Huron Gastroenterology PC
Ypsilanti 5015688, Michigan 5001836 48106
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Contact:
Site Public Contact
734-712-7251
MCRCwebsitecontactform@stjoeshealth.org

Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Contact:
Site Public Contact
218-333-5000
OncologyClinicalTrialsFargo@sanfordhealth.org

Minnesota Oncology - Burnsville
Burnsville 5019767, Minnesota 5037779 55337
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Cambridge Medical Center
Cambridge 5020068, Minnesota 5037779 55008
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779 55369
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779 55109
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Health Partners Inc
Minneapolis 5037649, Minnesota 5037779 55454
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Monticello Cancer Center
Monticello 5038045, Minnesota 5037779 55362
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

New Ulm Medical Center
New Ulm 5039173, Minnesota 5037779 56073
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Northland Medical Center
Princeton 5042360, Minnesota 5037779 55371
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779 55422
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

United Hospital
Saint Paul 5045360, Minnesota 5037779 55102
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779 55379
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Lakeview Hospital
Stillwater 5048814, Minnesota 5037779 55082
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Sanford Thief River Falls Medical Center
Thief River Falls 5049970, Minnesota 5037779 56701
Contact:
Site Public Contact
605-312-3320

Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779 55387
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779 56201
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Minnesota Oncology Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779 55125
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Sanford Cancer Center Worthington
Worthington 5053460, Minnesota 5037779 56187
Contact:
Site Public Contact
605-312-3320

Fairview Lakes Medical Center
Wyoming 5053526, Minnesota 5037779 55092
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus 4422442, Mississippi 4436296 39705
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Cancer Center-Grenada
Grenada 4428539, Mississippi 4436296 38901
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296 39216
Contact:
Site Public Contact
601-815-6700

Baptist Memorial Hospital and Cancer Center-Union County
New Albany 4438121, Mississippi 4436296 38652
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Oxford
Oxford 4440076, Mississippi 4436296 38655
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Saint Louis Cancer and Breast Institute-Ballwin
Ballwin 4375663, Missouri 4398678 63011
Contact:
Site Public Contact
314-251-7058

Central Care Cancer Center - Bolivar
Bolivar 4377835, Missouri 4398678 65613
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

Cox Cancer Center Branson
Branson 4378219, Missouri 4398678 65616
Contact:
Site Public Contact
417-269-4520

Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Southeast Cancer Center
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-651-5550

Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569

Capital Region Southwest Campus
Jefferson City 4392388, Missouri 4398678 65109
Contact:
Site Public Contact
573-632-4814
swooden@mail.crmc.org

Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Contact:
Site Public Contact
417-347-4030
LJCrockett@freemanhealth.com

Mercy Hospital Joplin
Joplin 4392768, Missouri 4398678 64804
Contact:
Site Public Contact
417-556-3074
esmeralda.carrillo@mercy.net

Truman Medical Centers
Kansas City 4393217, Missouri 4398678 64108
Contact:
Site Public Contact
816-404-4375

Lake Regional Hospital
Osage Beach 4402040, Missouri 4398678 65065
Contact:
Site Public Contact
573-302-2768
clinicaltrials@lakeregional.com

Delbert Day Cancer Institute at PCRMC
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-7504
research@phelpshealth.org

Mercy Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-6379

Heartland Regional Medical Center
Saint Joseph 4407010, Missouri 4398678 64506
Contact:
Site Public Contact
816-271-7937
linda.schumacher@mymlc.com

Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520

CoxHealth South Hospital
Springfield 4409896, Missouri 4398678 65807
Contact:
Site Public Contact
417-269-4520

Saint Louis Cancer and Breast Institute-South City
St Louis 4407066, Missouri 4398678 63109
Contact:
Site Public Contact
314-353-1870

Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
Contact:
Site Public Contact
314-525-6042
Danielle.Werle@mercy.net

Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066

Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569

Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569

Mercy Hospital Washington
Washington 4413621, Missouri 4398678 63090
Contact:
Site Public Contact
636-390-1600

Community Hospital of Anaconda
Anaconda 5637146, Montana 5667009 59711
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Bozeman Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Benefis Healthcare- Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Great Falls Clinic
Great Falls 5655240, Montana 5667009 59405
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kalispell Regional Medical Center
Kalispell 5660340, Montana 5667009 59901
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Patrick Hospital - Community Hospital
Missoula 5666639, Montana 5667009 59802
Contact:
Site Public Contact
406-327-3118
amy.hanneman@providence.org

Community Medical Hospital
Missoula 5666639, Montana 5667009 59804
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

CHI Health Good Samaritan
Kearney 5071348, Nebraska 5073708 68847
Contact:
Site Public Contact
308-865-7963
ResearchInstituteInquiries@CommonSpirit.org

Saint Elizabeth Regional Medical Center
Lincoln 5072006, Nebraska 5073708 68510
Contact:
Site Public Contact
855-313-2409
ResearchInstituteInquiries@CommonSpirit.org

Alegent Health Immanuel Medical Center
Omaha 5074472, Nebraska 5073708 68122
Contact:
Site Public Contact
402-717-1510
ResearchInstituteInquiries@CommonSpirit.org

Alegent Health Bergan Mercy Medical Center
Omaha 5074472, Nebraska 5073708 68124
Contact:
Site Public Contact
402-717-1510
ResearchInstituteInquiries@CommonSpirit.org

Alegent Health Lakeside Hospital
Omaha 5074472, Nebraska 5073708 68130
Contact:
Site Public Contact
402-717-1510
ResearchInstituteInquiries@CommonSpirit.org

Creighton University Medical Center
Omaha 5074472, Nebraska 5073708 68131
Contact:
Site Public Contact
402-717-1510
ResearchInstituteInquiries@CommonSpirit.org

Midlands Community Hospital
Papillion 5074792, Nebraska 5073708 68046
Contact:
Site Public Contact
402-717-1510
ResearchInstituteInquiries@CommonSpirit.org

Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700

Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215

South Nassau Cancer Center
Valley Stream 5142109, New York 5128638 11580
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

AdventHealth Infusion Center Asheville
Asheville 4453066, North Carolina 4482348 28803
Contact:
Site Public Contact
828-650-8037
AMBER.WHEELER@AdventHealth.com

AdventHealth Infusion Center Haywood
Clyde 4461150, North Carolina 4482348 28721
Contact:
Site Public Contact
828-650-8037
AMBER.WHEELER@AdventHealth.com

Margaret R Pardee Memorial Hospital
Hendersonville 4470592, North Carolina 4482348 28791
Contact:
Site Public Contact
828-696-4716
pardeecancerresearch@unchealth.unc.edu

AdventHealth Hendersonville
Hendersonville 4470592, North Carolina 4482348 28792
Contact:
Site Public Contact
828-650-8037
AMBER.WHEELER@AdventHealth.com

FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst 4485272, North Carolina 4482348 28374
Contact:
Site Public Contact
910-715-3500
jcwilliams@firsthealth.org

AdventHealth Infusion Center Weaverville
Weaverville 4497912, North Carolina 4482348 28787
Contact:
Site Public Contact
828-650-8037
AMBER.WHEELER@AdventHealth.com

Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford South University Medical Center
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
701-234-6161

Southpointe-Sanford Medical Center Fargo
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
605-312-3320

Sanford Medical Center Fargo
Fargo 5059163, North Dakota 5690763 58104
Contact:
Site Public Contact
800-437-4010

Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Contact:
Site Public Contact
701-234-6161
OncologyClinicalTrialsFargo@sanfordhealth.org

Indu and Raj Soin Medical Center
Beavercreek 4506008, Ohio 5165418 45431
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Saint Elizabeth Boardman Hospital
Boardman 5147784, Ohio 5165418 44512
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC-Miami Valley South
Centerville 4508204, Ohio 5165418 45459
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
Contact:
Site Public Contact
513-853-1300
ResearchInstituteInquiries@CommonSpirit.org

Oncology Hematology Care Inc-Kenwood
Cincinnati 4508722, Ohio 5165418 45236
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Bethesda North Hospital
Cincinnati 4508722, Ohio 5165418 45242
Contact:
Site Public Contact
513-853-1300
ResearchInstituteInquiries@CommonSpirit.org

TriHealth Cancer Institute-Westside
Cincinnati 4508722, Ohio 5165418 45247
Contact:
Site Public Contact
513-853-1300
ResearchInstituteInquiries@CommonSpirit.org

TriHealth Cancer Institute-Anderson
Cincinnati 4508722, Ohio 5165418 45255
Contact:
Site Public Contact
513-853-1300
ResearchInstituteInquiries@CommonSpirit.org

Dayton Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320

Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physician LLC-Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Armes Family Cancer Center
Findlay 5153924, Ohio 5165418 45840
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Blanchard Valley Hospital
Findlay 5153924, Ohio 5165418 45840
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Orion Cancer Care
Findlay 5153924, Ohio 5165418 45840
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC-Atrium
Franklin 4512203, Ohio 5165418 45005
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Dayton Physicians LLC-Wayne
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Wayne Hospital
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Greater Dayton Cancer Center
Kettering 4515843, Ohio 5165418 45409
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Kettering Medical Center
Kettering 4515843, Ohio 5165418 45429
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Toledo Clinic Cancer Centers-Maumee
Maumee 5162137, Ohio 5165418 43537
Contact:
Site Public Contact
pshoup@toledoclinic.com

Toledo Clinic Cancer Centers-Toledo
Toledo 5174035, Ohio 5165418 43623
Contact:
Site Public Contact
800-444-3561

Dayton Physicians LLC - Troy
Troy 5174358, Ohio 5165418 45373
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Saint Joseph Warren Hospital
Warren 5175865, Ohio 5165418 44484
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

Saint Elizabeth Youngstown Hospital
Youngstown 5177568, Ohio 5165418 44501
Contact:
Site Public Contact
937-528-2900
clinical.trials@daytonncorp.org

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Mercy Hospital Oklahoma City
Oklahoma City 4544349, Oklahoma 4544379 73120
Contact:
Site Public Contact
405-752-3402

Saint Alphonsus Medical Center-Baker City
Baker City 5712169, Oregon 5744337 97814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
Contact:
Site Public Contact
541-706-2909
nosall@stcharleshealthcare.org

Clackamas Radiation Oncology Center
Clackamas 5719308, Oregon 5744337 97015
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Cancer Institute Clackamas Clinic
Clackamas 5719308, Oregon 5744337 97015
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Bay Area Hospital
Coos Bay 5720495, Oregon 5744337 97420
Contact:
Site Public Contact
541-269-8392
cherie.cox@bayareahospital.org

Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150

Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Saint Alphonsus Medical Center-Ontario
Ontario 5744166, Oregon 5744337 97914
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Saint Charles Health System-Redmond
Redmond 5747882, Oregon 5744337 97756
Contact:
Site Public Contact
541-706-2909

Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742

Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927 18103
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927 18017
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Bryn Mawr Hospital
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Main Line Health Center-Collegeville
Collegeville 5184966, Pennsylvania 6254927 19426
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Pocono Medical Center
East Stroudsburg 5188075, Pennsylvania 6254927 18301
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Main Line Health Center-Exton
Exton 5189022, Pennsylvania 6254927 19341
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Lehigh Valley Hospital-Hazleton
Hazleton 5193011, Pennsylvania 6254927 18201
Contact:
Site Public Contact
610-402-9543
Morgan_M.Horton@lvhn.org

Riddle Memorial Hospital
Media 4559575, Pennsylvania 6254927 19063
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Bryn Mawr Health Center
Newtown Square 4560006, Pennsylvania 6254927 19073
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Paoli Memorial Hospital
Paoli 5205037, Pennsylvania 6254927 19301
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Lankenau Medical Center
Wynnewood 5220230, Pennsylvania 6254927 19096
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Women and Infants Hospital
Providence 5224151, Rhode Island 5224323 02905
Contact:
Site Public Contact
401-274-1122

Prisma Health Cancer Institute - Spartanburg
Boiling Springs 4571805, South Carolina 4597040 29316
Contact:
Site Public Contact
864-241-6251

Prisma Health Cancer Institute - Easley
Easley 4577263, South Carolina 4597040 29640
Contact:
Site Public Contact
864-522-2066
Kim.Williams3@prismahealth.org

Prisma Health Cancer Institute - Butternut
Greenville 4580543, South Carolina 4597040 29605
Contact:
Site Public Contact
864-241-6251

Prisma Health Cancer Institute - Faris
Greenville 4580543, South Carolina 4597040 29605
Contact:
Site Public Contact
864-241-6251

Prisma Health Cancer Institute - Eastside
Greenville 4580543, South Carolina 4597040 29615
Contact:
Site Public Contact
864-241-6251

Prisma Health Cancer Institute - Greer
Greer 4580599, South Carolina 4597040 29650
Contact:
Site Public Contact
864-241-6251

Prisma Health Cancer Institute - Seneca
Seneca 4595346, South Carolina 4597040 29672
Contact:
Site Public Contact
864-241-6251

Lexington Medical Center
West Columbia 4600541, South Carolina 4597040 29169
Contact:
Site Public Contact
803-791-2105
LMCIRB@lexhealth.org

Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Contact:
Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Bon Secours Memorial Regional Medical Center
Mechanicsville 4772566, Virginia 6254928 23116
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Westchester Emergency Center
Midlothian 4772943, Virginia 6254928 23113
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Saint Francis Medical Center
Midlothian 4772943, Virginia 6254928 23114
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Richmond Community Hospital
Richmond 4781708, Virginia 6254928 23223
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Saint Mary's Hospital
Richmond 4781708, Virginia 6254928 23226
Contact:
Site Public Contact
804-893-8978
anne_carmellat@bshsi.org

Bon Secours Cancer Institute at Reynolds Crossing
Richmond 4781708, Virginia 6254928 23230
Contact:
Site Public Contact
804-893-8978
Anne_caramella@bshsi.org

Providence Regional Cancer System-Aberdeen
Aberdeen 5785243, Washington 5815135 98520
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

PeaceHealth Saint Joseph Medical Center
Bellingham 5786899, Washington 5815135 98225
Contact:
Site Public Contact
360-788-8223

Harrison Medical Center
Bremerton 5788054, Washington 5815135 98310
Contact:
Site Public Contact
253-426-6882
ResearchInstituteInquiries@CommonSpirit.org

Providence Regional Cancer System-Centralia
Centralia 5789683, Washington 5815135 98531
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

Swedish Cancer Institute-Edmonds
Edmonds 5793427, Washington 5815135 98026
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Providence Regional Cancer Partnership
Everett 5793933, Washington 5815135 98201
Contact:
Site Public Contact
425-261-3529
marilyn.birchman@providence.org

Swedish Cancer Institute-Issaquah
Issaquah 5798487, Washington 5815135 98029
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Kadlec Clinic Hematology and Oncology
Kennewick 5799610, Washington 5815135 99336
Contact:
Site Public Contact
509-783-4637
research@kadlecmed.org

Providence Regional Cancer System-Lacey
Lacey 5800112, Washington 5815135 98503
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

PeaceHealth Saint John Medical Center
Longview 5801617, Washington 5815135 98632
Contact:
Site Public Contact
360-514-2016
kmakin-bond@peacehealth.org

Swedish Medical Center-Ballard Campus
Seattle 5809844, Washington 5815135 98107
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Swedish Medical Center-Cherry Hill
Seattle 5809844, Washington 5815135 98122-5711
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135 98122
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

PeaceHealth United General Medical Center
Sedro-Woolley 5809902, Washington 5815135 98284
Contact:
Site Public Contact
360-788-8238
lkey@peacehealth.org

Providence Regional Cancer System-Shelton
Shelton 5810176, Washington 5815135 98584
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

PeaceHealth Southwest Medical Center
Vancouver 5814616, Washington 5815135 98664
Contact:
Site Public Contact
360-514-3940
kmakin-bond@peacehealth.org

Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Contact:
Site Public Contact
oncologyresearch@lhs.org

Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150

Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Contact:
Site Public Contact
509-897-5993
Cheryl.Dodd@providence.org

Providence Regional Cancer System-Yelm
Yelm 5816656, Washington 5815135 98597
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Marshfield Clinic-Minocqua Center
Minocqua 5263156, Wisconsin 5279468 54548
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468 54017
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Billings Clinic-Cody
Cody 5821593, Wyoming 5843591 82414
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Welch Cancer Center
Sheridan 5838198, Wyoming 5843591 82801
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Cancer Center-Metro Medical Center Bayamon
Bayamón 4562831, Puerto Rico 00959-5060
Contact:
Site Public Contact
787-395-7085

Doctors Cancer Center
Manatí 4566137, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397

San Juan Community Oncology Group
San Juan 4568127, Puerto Rico 00917
Contact:
Site Public Contact
787-274-3387

Centro Comprensivo de Cancer de UPR
San Juan 4568127, Puerto Rico 00927
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

PROncology
San Juan 4568127, Puerto Rico 00927
Contact:
Site Public Contact
787-919-7919
info@PRoncology.com

San Juan City Hospital
San Juan 4568127, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296

More Details

NCT ID
NCT05929768
Status
Recruiting
Sponsor
SWOG Cancer Research Network

Study Contact

Alicia Aranda
210-614-8808
aaranda@swog.org

Detailed Description

PRIMARY OBJECTIVE: I. To assess whether participants with early stage triple negative breast cancer (TNBC) randomized to receive anthracycline-free, taxane-platinum neoadjuvant chemotherapy with pembrolizumab have non-inferior breast cancer event-free survival (BC-EFS) compared to participants randomized to taxane-platinum-anthracycline neoadjuvant chemotherapy with pembrolizumab. SECONDARY OBJECTIVES: I. To compare pathological complete response (pCR) and residual cancer burden (RCB) rates by randomized arm. II. To compare pCR and RCB rates between randomized arms by tumor infiltrating lymphocytes (TIL) status. III. To compare BC-EFS between randomized arms in the TIL-enriched and non-TIL enriched subgroups. IV. To compare distant relapse-free survival and overall survival by randomized arm. V. To compare invasive breast cancer-free survival after surgery between randomized arms in pCR and residual disease groups. VI. To compare the safety and tolerability by randomized arm among those that initiate therapy. TRANSLATIONAL MEDICINE OBJECTIVE: I. To evaluate concordance and accuracy of an automated stromal TIL (sTIL) algorithm versus (vs.) central pathologist assessed sTILs quantification. PATIENT REPORTED OUTCOME (PRO) OBJECTIVES: I. To compare patient-reported fatigue at 3 weeks after the last neoadjuvant systemic therapy (NAST) dose and, separately, at 18 months after randomization, using the Patient Reported Outcomes Measurement Information System (PROMIS) Fatigue-7a in participants undergoing NAST with taxane-platinum-anthracycline chemo-immunotherapy vs taxane-platinum chemo-immunotherapy. (Quality of Life, Primary) II. To compare physical function experienced by participants undergoing neoadjuvant systemic chemotherapy (NAST) with taxane-platinum-anthracycline chemo-immunotherapy vs taxane-platinum chemo-immunotherapy, within 3-5 weeks post last neoadjuvant systemic therapy dose using the PROMIS-29 Profile physical function subscale score. (Quality of Life, Secondary) III. To compare physical function experienced by participants undergoing NAST taxane-platinum-anthracycline chemo-immunotherapy vs taxane-platinum chemo-immunotherapy at 18 months post registration using the PROMIS-29 Profile physical function subscale score. (Quality of Life, Secondary) IV. To compare other PROMIS-29 Profile subscale scores (sleep disturbance, depression, anxiety, social, pain interference, and pain sensitivity) and GP5 question response by arm within 3-5 weeks post last neoadjuvant systemic therapy dose and at 18 months post registration. (Quality of Life, Exploratory) V. To compare the GP-5 item scores by arm within 3-5 weeks post last neoadjuvant systemic therapy dose and at 18 months post registration. (Quality of Life, Exploratory) VI. To compare select patient-reported outcomes using the Common Terminology Criteria for Adverse Events (PRO-CTCAE) by arm. (Patient-Reported Symptoms of Treatment) BANKING OBJECTIVE: I. To bank physical specimens and digital slides for future correlative studies. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive paclitaxel intravenously (IV), carboplatin IV, and pembrolizumab IV on study. Patients then receive doxorubicin IV, cyclophosphamide IV, and pembrolizumab IV on study. Patients then undergo surgery. Patients may receive pembrolizumab after surgery. Patients may optionally undergo collection of blood samples throughout the trial. ARM II: Patients receive docetaxel IV, carboplatin IV, and pembrolizumab IV on study. Patients then undergo surgery. Patients may receive pembrolizumab after surgery. Patients may optionally undergo collection of blood samples throughout the trial. Patients are followed up every 6 months for the first 2 years and then annually until 5 years from registration.