E-Mindfulness Approaches for Living After Breast Cancer
Purpose
NRG-CC015 is a prospective, randomized phase III clinical trial to evaluate the efficacy of two distinct digital approaches for delivering a mindfulness-based intervention: a live, instructor-led version delivered over Zoom (MAPs LO), and an app-based, self-paced version (MAPs App). Participants will include younger breast cancer survivors (BCS) who were diagnosed with breast cancer at or before age 50 years, have completed their primary cancer treatment (i.e., surgery, radiation, and/or chemotherapy) at least 6 months earlier, and report elevated depressive symptoms.
Conditions
- Breast Cancer
- Depression
Eligibility
- Eligible Ages
- Between 18 Years and 50 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- The participant or a legally authorized representative must provide study-specific informed consent prior to pre-entry and, for participants treated in the U.S., authorization permitting release of personal health information. - The participant must have been greater than or equal to 18 or less than or equal to 50 years of age at the time of breast cancer diagnosis. - The participant must have a first-time diagnosis of non-metastatic breast cancer which is Stage 0, I, II, or III. - The participant must have a score of greater than or equal to 5 and less than or equal to 14 on the Patient Health Questionnaire-8 item (PHQ-8). - Participants must have completed all primary breast cancer treatments at least 6 months prior to and no more than 5 years prior to registration. Note: Primary treatments include surgery, radiation therapy, adjuvant chemotherapy, targeted therapies (e.g., PARP (poly-ADP ribose polymerase) inhibitors, CDK4/6 inhibitors, TDM-1, pertuzumab, or immunotherapy). (Participants may still be taking adjuvant therapy with trastuzumab or adjuvant endocrine therapy or completing minor reconstructive surgery.) - Participant must be able to understand, speak, read, and write in English or Spanish. - Participant must be willing to participate in a 6-week program to receive training in mindfulness. - Participant must be able to use a smartphone, tablet, or other digital device. - Sex assigned at birth must be female.
Exclusion Criteria
- Patient Health Questionnaire-8 item (PHQ-8) score of less than 5 or greater than 14 . - Any history or current evidence of recurrent or metastatic breast cancer. - Current or past history of another cancer. Participants with a history of only non-melanoma skin cancer or in situ cervical cancer without chemotherapy treatment would be eligible. - Currently pregnant or planning to become pregnant in the near future. - Participants who are enrolled in other cancer control or behavioral intervention trials that require frequent assessments or training activities.
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Prevention
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Mindfulness (MAPs) Live Online |
Participants assigned to MAPs Live Online (MAPs LO) will be asked to attend 2-hour group sessions once a week for 6 weeks conducted live online over Zoom. Both English and Spanish language participants will be randomized to Arm 1. Sessions will be conducted on an encrypted internet connection and recorded for quality assurance and intervention fidelity. Participants who do not have a home computer, smartphone, tablet, or internet to access the Zoom sessions will have a tablet and hotspot provided by the UCLA research team. Each session provides structured lessons and guided exercises in mindfulness as well as opportunities for reflection and group discussion. Exercises include breath, body, and sound meditations; eating and walking meditations; managing pain; working with difficult thoughts and emotions; and cultivating loving kindness. Home practice is a key component of MAPs, and participants will be instructed to practice mindfulness techniques daily, beginning with 5 minutes |
|
|
Experimental Mindfulness (MAPs) Digital App |
Participants assigned to this condition will be asked to access the MAPs App on their home computer, smartphone, or study supplied tablet over the 6-week intervention period. This will be provided by the UCLA research team. Only English language speakers will be assigned to Arm 2, as the app is currently available only in English at this time. Participants who do not have a home computer, smartphone, tablet, or internet to access the digital app will be provided with a tablet and hotspot by the UCLA research team. The MAPs App translates the content of the MAPs intervention into an app-based format, with lessons, exercises, and guided discussions from the six 2-hour sessions separated into shorter micro-sessions. The digital program is sequential with new content and exercises building on previous sessions. Lessons and other materials are gradually unlocked as participants progress through the program. Engagement with the MAPs App will be tracked to determine "dose" of the inte |
|
|
Active Comparator Meditation Only Control Group |
The participants assigned to this condition will be provided with access to guided audio mindfulness meditations developed by the UCLA MARC (Mindfulness Awareness Research Center) and available on an app. Both English and Spanish speakers will be assigned to Arm 3, and the meditations will be available in both languages. Participants who do not have a home computer, smartphone, tablet, or internet to access the meditations will be provided with a tablet and hotspot by the UCLA research team. Use of the meditations will be tracked to determine "dose" of the intervention received. All three study groups will have access to the UCLA MARC mindfulness meditation app throughout the study duration out to 6 months of follow-up. |
|
Recruiting Locations
Mayo Clinic Hospital in Arizona
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Chico, California 95926
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Honolulu, Hawaii 96819
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Chicago, Illinois 60611
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Carle at The Riverfront
Danville, Illinois 61832
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Decatur, Illinois 62526
Decatur, Illinois 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
DeKalb, Illinois 60115
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Dixon, Illinois 61021
Dixon, Illinois 61021
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Eureka, Illinois 61530
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Galesburg, Illinois 61401
Galesburg, Illinois 61401
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Geneva, Illinois 60134
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Glenview, Illinois 60026
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Grayslake, Illinois 60030
Grayslake, Illinois 60030
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Kewanee, Illinois 61443
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Lake Forest, Illinois 60045
Lake Forest, Illinois 60045
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Lisle, Illinois 60532
Lisle, Illinois 60532
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Macomb, Illinois 61455
Macomb, Illinois 61455
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Mattoon, Illinois 61938
Mattoon, Illinois 61938
Loyola University Medical Center
Maywood, Illinois 60153
Maywood, Illinois 60153
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SSM Health Good Samaritan
Mount Vernon, Illinois 62864
Mount Vernon, Illinois 62864
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Normal, Illinois 61761
Normal, Illinois 61761
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
Northwestern Medicine Oak Brook
Oak Brook, Illinois 60523
Oak Brook, Illinois 60523
Rush MD Anderson Cancer Center at Rush Oak Park
Oak Park, Illinois 60304
Oak Park, Illinois 60304
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Orland Park, Illinois 60462
Orland Park, Illinois 60462
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Ottawa, Illinois 61350
Ottawa, Illinois 61350
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Pekin, Illinois 61554
Pekin, Illinois 61554
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Peoria, Illinois 61615
Peoria, Illinois 61615
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Peru, Illinois 61354
Peru, Illinois 61354
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Princeton, Illinois 61356
Princeton, Illinois 61356
OSF Saint Anthony Medical Center
Rockford, Illinois 61108
Rockford, Illinois 61108
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Springfield, Illinois 62702
Springfield, Illinois 62702
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Springfield, Illinois 62702
Springfield, Illinois 62702
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Urbana, Illinois 61801
Urbana, Illinois 61801
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Washington, Illinois 61571
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Goshen, Indiana 46526
Goshen, Indiana 46526
Memorial Hospital of South Bend
South Bend, Indiana 46601
South Bend, Indiana 46601
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UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa 50023
Ankeny, Iowa 50023
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Bettendorf, Iowa 52722
Bettendorf, Iowa 52722
Saint Anthony Regional Hospital
Carroll, Iowa 51401
Carroll, Iowa 51401
Saint Luke's Hospital
Cedar Rapids, Iowa 52402
Cedar Rapids, Iowa 52402
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
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319-363-2690
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319-363-2690
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Clive, Iowa 50325
Clive, Iowa 50325
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Des Moines, Iowa 50309
Des Moines, Iowa 50309
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Des Moines, Iowa 50309
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Des Moines, Iowa 50314
Des Moines, Iowa 50314
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Des Moines, Iowa 50314
Des Moines, Iowa 50314
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Iowa City, Iowa 52242
Iowa City, Iowa 52242
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800-237-1225
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800-237-1225
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Pella, Iowa 50219
Pella, Iowa 50219
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Waukee, Iowa 50263
Waukee, Iowa 50263
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Cotton O'Neil Cancer Center / Stormont Vail Health
Topeka, Kansas 66606
Topeka, Kansas 66606
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785-270-4939
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Flaget Memorial Hospital
Bardstown, Kentucky 40004
Bardstown, Kentucky 40004
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Lexington, Kentucky 40509
Lexington, Kentucky 40509
University Medical Center New Orleans
New Orleans, Louisiana 70112
New Orleans, Louisiana 70112
Maryland Proton Treatment Center
Baltimore, Maryland 21201
Baltimore, Maryland 21201
University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
Baltimore, Maryland 21201
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800-888-8823
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800-888-8823
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Baltimore, Maryland 21237
Baltimore, Maryland 21237
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443-777-7364
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443-777-7364
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Baltimore, Maryland 21239
Baltimore, Maryland 21239
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Bel Air, Maryland 21014
Bel Air, Maryland 21014
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443-643-3010
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Bel Air, Maryland 21015
Bel Air, Maryland 21015
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Clinton, Maryland 20735
Clinton, Maryland 20735
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301-877-4673
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301-877-4673
Central Maryland Radiation Oncology in Howard County
Columbia, Maryland 21044
Columbia, Maryland 21044
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443-546-1300
University of Maryland Shore Medical Center at Easton
Easton, Maryland 21601
Easton, Maryland 21601
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Glen Burnie, Maryland 21061
Glen Burnie, Maryland 21061
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410-553-8100
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Largo, Maryland 20774
Largo, Maryland 20774
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Olney, Maryland 20832
Olney, Maryland 20832
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Towson, Maryland 21204
Towson, Maryland 21204
Beverly Hospital
Beverly, Massachusetts 01915
Beverly, Massachusetts 01915
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978-922-3000
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978-922-3000
Tufts Medical Center
Boston, Massachusetts 02111
Boston, Massachusetts 02111
Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
Burlington, Massachusetts 01805
Addison Gilbert Hospital
Gloucester, Massachusetts 01930
Gloucester, Massachusetts 01930
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978-283-4000
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978-283-4000
Lowell General Hospital
Lowell, Massachusetts 01854
Lowell, Massachusetts 01854
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Peabody, Massachusetts 01960
Peabody, Massachusetts 01960
Tufts Medical Center Cancer Center Stoneham
Stoneham, Massachusetts 02180
Stoneham, Massachusetts 02180
MyMichigan Medical Center Gratiot
Alma, Michigan 48801
Alma, Michigan 48801
MyMichigan Medical Center Alpena
Alpena, Michigan 49707
Alpena, Michigan 49707
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
Ann Arbor, Michigan 48106
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 48183
Brownstown, Michigan 48183
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
Clinton Township, Michigan 48038
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Dearborn, Michigan 48126
Dearborn, Michigan 48126
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Detroit, Michigan 48202
Detroit, Michigan 48202
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Gladwin, Michigan 48624
Gladwin, Michigan 48624
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Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Allegiance Health
Jackson, Michigan 49201
Jackson, Michigan 49201
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Lansing, Michigan 48912
Lansing, Michigan 48912
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Midland, Michigan 48670
Midland, Michigan 48670
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Mount Pleasant, Michigan 48858
Mount Pleasant, Michigan 48858
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Novi, Michigan 48374
Novi, Michigan 48374
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Novi, Michigan 48377
Novi, Michigan 48377
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Pontiac, Michigan 48341
Pontiac, Michigan 48341
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Reed City, Michigan 49677
Reed City, Michigan 49677
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Saginaw, Michigan 48601
Saginaw, Michigan 48601
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Southfield, Michigan 48075
Southfield, Michigan 48075
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Tawas City, Michigan 48764
Tawas City, Michigan 48764
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
West Bloomfield, Michigan 48322
Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota 56401
Brainerd, Minnesota 56401
Essentia Health Cancer Center
Duluth, Minnesota 55805
Duluth, Minnesota 55805
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota 56001
Mankato, Minnesota 56001
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855-776-0015
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855-776-0015
Mayo Clinic in Rochester
Rochester, Minnesota 55905
Rochester, Minnesota 55905
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855-776-0015
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855-776-0015
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi 39705
Columbus, Mississippi 39705
Baptist Cancer Center-Grenada
Grenada, Mississippi 38901
Grenada, Mississippi 38901
Mississippi Baptist Medical Center
Jackson, Mississippi 39202
Jackson, Mississippi 39202
Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652
New Albany, Mississippi 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655
Oxford, Mississippi 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
Southhaven, Mississippi 38671
Lake Regional Hospital
Osage Beach, Missouri 65065
Osage Beach, Missouri 65065
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
Saint Joseph, Missouri 64506
Mercy Hospital Springfield
Springfield, Missouri 65804
Springfield, Missouri 65804
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417-269-4520
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417-269-4520
Mercy Hospital South
St Louis, Missouri 63128
St Louis, Missouri 63128
Missouri Baptist Medical Center
St Louis, Missouri 63131
St Louis, Missouri 63131
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314-996-5569
Site Public Contact
314-996-5569
CHI Health Good Samaritan
Kearney, Nebraska 68847
Kearney, Nebraska 68847
Summit Medical Group
Berkeley Heights, New Jersey 07922
Berkeley Heights, New Jersey 07922
Ocean University Medical Center
Brick, New Jersey 08724
Brick, New Jersey 08724
Contact:
Site Public Contact
201-880-3669
Site Public Contact
201-880-3669
AtlantiCare Health Park-Cape May Court House
Cape May Court House, New Jersey 08210
Cape May Court House, New Jersey 08210
Contact:
Site Public Contact
609-677-7735
Site Public Contact
609-677-7735
AtlantiCare Surgery Center
Egg Harbor, New Jersey 08234
Egg Harbor, New Jersey 08234
Contact:
Site Public Contact
609-748-7200
Site Public Contact
609-748-7200
Hunterdon Medical Center
Flemington, New Jersey 08822
Flemington, New Jersey 08822
Contact:
Site Public Contact
908-237-2330
Site Public Contact
908-237-2330
Summit Health - Florham Park Campus
Florham Park, New Jersey 07932
Florham Park, New Jersey 07932
Bayshore Community Hospital
Holmdel, New Jersey 07733
Holmdel, New Jersey 07733
Southern Ocean County Medical Center
Manahawkin, New Jersey 08050
Manahawkin, New Jersey 08050
Contact:
Site Public Contact
609-978-3429
Site Public Contact
609-978-3429
Jersey Shore Medical Center
Neptune City, New Jersey 07753
Neptune City, New Jersey 07753
Contact:
Site Public Contact
732-776-4240
Site Public Contact
732-776-4240
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey 07652
Paramus, New Jersey 07652
Riverview Medical Center/Booker Cancer Center
Red Bank, New Jersey 07701
Red Bank, New Jersey 07701
Contact:
Site Public Contact
732-530-2382
Site Public Contact
732-530-2382
Valley Health System Ridgewood Campus
Ridgewood, New Jersey 07450
Ridgewood, New Jersey 07450
Glens Falls Hospital
Glens Falls, New York 12801
Glens Falls, New York 12801
Contact:
Site Public Contact
518-926-6700
Site Public Contact
518-926-6700
Garnet Health Medical Center
Middletown, New York 10940
Middletown, New York 10940
Mount Sinai Union Square
New York, New York 10003
New York, New York 10003
Mount Sinai Chelsea
New York, New York 10011
New York, New York 10011
Mount Sinai Hospital
New York, New York 10029
New York, New York 10029
Montefiore Medical Center-Einstein Campus
The Bronx, New York 10461
The Bronx, New York 10461
Cone Health MedCenter Asheboro
Asheboro, North Carolina 27205
Asheboro, North Carolina 27205
Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina 27215
Burlington, North Carolina 27215
Cone Health Cancer Center
Greensboro, North Carolina 27403
Greensboro, North Carolina 27403
Cone Health Cancer Center at Drawbridge Parkway
Greensboro, North Carolina 27410
Greensboro, North Carolina 27410
Annie Penn Memorial Hospital
Reidsville, North Carolina 27320
Reidsville, North Carolina 27320
Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Sanford Broadway Medical Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
Beavercreek, Ohio 45431
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
Cincinnati, Ohio 45219
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Columbus, Ohio 43210
Mount Carmel East Hospital
Columbus, Ohio 43213
Columbus, Ohio 43213
Armes Family Cancer Center
Findlay, Ohio 45840
Findlay, Ohio 45840
Blanchard Valley Hospital
Findlay, Ohio 45840
Findlay, Ohio 45840
Mount Carmel Grove City Hospital
Grove City, Ohio 43123
Grove City, Ohio 43123
Kettering Medical Center
Kettering, Ohio 45429
Kettering, Ohio 45429
Saint Rita's Medical Center
Lima, Ohio 45801
Lima, Ohio 45801
Memorial Hospital
Marysville, Ohio 43040
Marysville, Ohio 43040
Licking Memorial Hospital
Newark, Ohio 43055
Newark, Ohio 43055
Mercy Health - Perrysburg Hospital
Perrysburg, Ohio 43551
Perrysburg, Ohio 43551
Mercy Health - Saint Anne Hospital
Toledo, Ohio 43623
Toledo, Ohio 43623
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
West Chester, Ohio 45069
Saint Ann's Hospital
Westerville, Ohio 43081
Westerville, Ohio 43081
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio 44501
Youngstown, Ohio 44501
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Saint Charles Health System
Bend, Oregon 97701
Bend, Oregon 97701
Kaiser Permanente Northwest
Portland, Oregon 97227
Portland, Oregon 97227
Saint Charles Health System-Redmond
Redmond, Oregon 97756
Redmond, Oregon 97756
Contact:
Site Public Contact
541-706-2909
Site Public Contact
541-706-2909
Carlisle Regional Cancer Center
Carlisle, Pennsylvania 17015
Carlisle, Pennsylvania 17015
WellSpan Medical Oncology and Hematology
Chambersburg, Pennsylvania 17201
Chambersburg, Pennsylvania 17201
Contact:
Site Public Contact
717-217-6020
Site Public Contact
717-217-6020
Geisinger Medical Center
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
Geisinger Cancer Center Dickson City
Dickson City, Pennsylvania 18519
Dickson City, Pennsylvania 18519
Ephrata Cancer Center
Ephrata, Pennsylvania 17522
Ephrata, Pennsylvania 17522
Contact:
Site Public Contact
717-721-4840
Site Public Contact
717-721-4840
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505
Erie, Pennsylvania 16505
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania 16121
Farrell, Pennsylvania 16121
Adams Cancer Center
Gettysburg, Pennsylvania 17325
Gettysburg, Pennsylvania 17325
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
Greensburg, Pennsylvania 15601
Contact:
Site Public Contact
724-838-1900
Site Public Contact
724-838-1900
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109
Harrisburg, Pennsylvania 17109
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania 18201
Hazleton, Pennsylvania 18201
Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033-0850
Hershey, Pennsylvania 17033-0850
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, Pennsylvania 15901
Johnstown, Pennsylvania 15901
Contact:
Site Public Contact
814-534-4724
Site Public Contact
814-534-4724
Lancaster General Ann B Barshinger Cancer Institute
Lancaster, Pennsylvania 17601
Lancaster, Pennsylvania 17601
Sechler Family Cancer Center
Lebanon, Pennsylvania 17042
Lebanon, Pennsylvania 17042
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
Lewisburg, Pennsylvania 17837
Redeemer Health
Meadowbrook, Pennsylvania 19046
Meadowbrook, Pennsylvania 19046
Contact:
Site Public Contact
215-938-3555
Site Public Contact
215-938-3555
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050
Mechanicsburg, Pennsylvania 17050
UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant, Pennsylvania 15666
Mount Pleasant, Pennsylvania 15666
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania 15642
N. Huntingdon, Pennsylvania 15642
UPMC Hillman Cancer Center - New Castle
New Castle, Pennsylvania 16105
New Castle, Pennsylvania 16105
UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania 15213
Pittsburgh, Pennsylvania 15213
Contact:
Site Public Contact
412-647-2811
Site Public Contact
412-647-2811
UPMC-Saint Margaret
Pittsburgh, Pennsylvania 15215
Pittsburgh, Pennsylvania 15215
Contact:
Site Public Contact
412-784-4900
Site Public Contact
412-784-4900
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania 15232
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-621-2334
Site Public Contact
412-621-2334
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania 17901
Pottsville, Pennsylvania 17901
Chester County Hospital
West Chester, Pennsylvania 19380
West Chester, Pennsylvania 19380
Reading Hospital
West Reading, Pennsylvania 19611
West Reading, Pennsylvania 19611
Contact:
Site Public Contact
610-988-9323
Site Public Contact
610-988-9323
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
Wilkes-Barre, Pennsylvania 18711
WellSpan Health-York Cancer Center
York, Pennsylvania 17403
York, Pennsylvania 17403
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
UPMC Memorial
York, Pennsylvania 17408
York, Pennsylvania 17408
Contact:
Site Public Contact
717-724-6760
Site Public Contact
717-724-6760
Women and Infants Hospital
Providence, Rhode Island 02905
Providence, Rhode Island 02905
Contact:
Site Public Contact
401-274-1122
Site Public Contact
401-274-1122
Beaufort Memorial Hospital
Beaufort, South Carolina 29902
Beaufort, South Carolina 29902
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina 29316
Boiling Springs, South Carolina 29316
Medical University of South Carolina
Charleston, South Carolina 29425
Charleston, South Carolina 29425
Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
Easley, South Carolina 29640
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina 29440
Georgetown, South Carolina 29440
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
Greenville, South Carolina 29615
Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
Greer, South Carolina 29650
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
Seneca, South Carolina 29672
Rapid City Regional Hospital
Rapid City, South Dakota 57701
Rapid City, South Dakota 57701
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Sioux Falls, South Dakota 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Sioux Falls, South Dakota 57117-5134
University of Tennessee - Knoxville
Knoxville, Tennessee 37920
Knoxville, Tennessee 37920
Contact:
Site Public Contact
865-544-9773
Site Public Contact
865-544-9773
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Memphis, Tennessee 38120
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee 37204
Nashville, Tennessee 37204
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106
Amarillo, Texas 79106
Inova Alexandria Hospital
Alexandria, Virginia 22304
Alexandria, Virginia 22304
Inova Schar Cancer Institute
Fairfax, Virginia 22031
Fairfax, Virginia 22031
Inova Fair Oaks Hospital
Fairfax, Virginia 22033
Fairfax, Virginia 22033
Inova Fairfax Hospital
Falls Church, Virginia 22042
Falls Church, Virginia 22042
Inova Loudoun Hospital
Leesburg, Virginia 20176
Leesburg, Virginia 20176
Centra Alan B Pearson Regional Cancer Center
Lynchburg, Virginia 24501
Lynchburg, Virginia 24501
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
Mechanicsville, Virginia 23116
Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
Midlothian, Virginia 23114
Bon Secours Richmond Community Hospital
Richmond, Virginia 23223
Richmond, Virginia 23223
Bon Secours Saint Mary's Hospital
Richmond, Virginia 23226
Richmond, Virginia 23226
Virginia Cancer Institute
Richmond, Virginia 23229
Richmond, Virginia 23229
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
Richmond, Virginia 23235
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
Richmond, Virginia 23298
Carilion Roanoke Memorial Hospital
Roanoke, Virginia 24033
Roanoke, Virginia 24033
Contact:
Site Public Contact
540-981-7377
Site Public Contact
540-981-7377
VCU Community Memorial Health Center
South Hill, Virginia 23970
South Hill, Virginia 23970
Saint Joseph Medical Center Hematology and Oncology - Silverdale
Silverdale, Washington 98383
Silverdale, Washington 98383
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Antigo, Wisconsin 54409
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
Appleton, Wisconsin 54911
ThedaCare Cancer Care - Berlin
Berlin, Wisconsin 54923
Berlin, Wisconsin 54923
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Green Bay, Wisconsin 54303
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Aspirus Medford Hospital
Medford, Wisconsin 54451
Medford, Wisconsin 54451
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
Mukwonago, Wisconsin 53149
ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin 54956
Neenah, Wisconsin 54956
ThedaCare Cancer Care - New London
New London, Wisconsin 54961
New London, Wisconsin 54961
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Oconomowoc, Wisconsin 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
Oconto Falls, Wisconsin 54154
ThedaCare Cancer Care - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander, Wisconsin 54501
Rhinelander, Wisconsin 54501
ThedaCare Cancer Care - Shawano
Shawano, Wisconsin 54166
Shawano, Wisconsin 54166
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Aspirus Cancer Care - Stevens Point
Stevens Point, Wisconsin 54481
Stevens Point, Wisconsin 54481
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
Sturgeon Bay, Wisconsin 54235-1495
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Waukesha, Wisconsin 53188
ThedaCare Cancer Care - Waupaca
Waupaca, Wisconsin 54981
Waupaca, Wisconsin 54981
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Wausau, Wisconsin 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids, Wisconsin 54494
Wisconsin Rapids, Wisconsin 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
Memorial Hospital of Sweetwater County
Rock Springs, Wyoming 82901
Rock Springs, Wyoming 82901
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
PROncology
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
More Details
- NCT ID
- NCT06748222
- Status
- Recruiting
- Sponsor
- NRG Oncology
Detailed Description
The goal of this trial is to determine if a digital mindfulness meditation-based intervention program can improve the mental health and well-being among younger breast cancer survivors with elevated symptoms of depression. Mindfulness meditation programs provided in person have been shown to be helpful for younger breast cancer survivors. This study will compare different digital approaches for mindfulness training to see which is the most effective. This study will also explore mediators and moderators of intervention effects, which is key for efficiently targeting psychological resources in the oncology setting and may be particularly relevant for deciding between digital intervention approaches for individual patients. Research on moderators of in-person mindfulness-based interventions (MBIs) in cancer populations suggests that patients with worse psychological functioning at study entry tend to benefit more from these interventions, with mixed effects for other predictors. It is unclear whether more distressed patients will show similar benefits in digital interventions that lack in-person check-ins and monitoring by instructors. Thus, investigators will assess baseline distress along with key demographic characteristics and social determinants of health (e.g., race, ethnicity, education, rurality) as potential moderators. With respect to mediators, emotion regulation strategies including rumination and self-kindness have been shown to mediate effects of in-person MBIs on stress and depression in cancer populations, consistent with the broader theoretical and empirical literature on mindfulness. Determining whether these factors predict and explain effects of digital MBIs, and whether these effects differ by delivery mode, is necessary for achieving optimal outcomes of these interventions. Further, investigators will collect information on the cost-effectiveness of these programs, which is critical for payors to make coverage decisions, healthcare providers and employers to make adoption decisions, and patients to make participation decisions.