UAMS - Translational Research Institute

Condition

• Multiple Myeloma

Eligibility

Eligible Ages

Over 18 Years

Eligible Sex

All

Accepts Healthy Volunteers

No

Criteria

Inclusion:

- Documented diagnosis of multiple myeloma (MM) as defined by the criteria below:

1. MM diagnosis according to the international myeloma working group (IMWG)
diagnostic criteria

2. Measurable disease at screening as assessed by central laboratory

- Received at least 3 prior lines of antimyeloma therapy including a proteasome
inhibitor (PI), an immunomodulatory drug (IMiD), and an anti-cluster of
differentiation (CD)38 antibody

- Documented evidence of progressive disease (PD) or failure to achieve a response to
the last line of therapy based on investigator's determination of response by IMWG
criteria

- Toxicity related to previous anticancer therapy must have resolved to Grade 1 or
better

- Have an eastern cooperative oncology group (ECOG) performance status of 0 to 2 at
screening and immediately before the start of study treatment administration

Exclusion:

- Active hepatitis of infectious origin

- Known active or prior central nervous system (CNS) involvement or exhibits clinical
signs of meningeal involvement of MM

- Suspected or known allergies, hypersensitivity, or intolerance to the excipients of
JNJ-79635322 and Teclistamab

- Major surgery, (example, requiring general anesthesia) within 2 weeks before first
dose, or will not have fully recovered from surgery, or has surgery planned during
the time the participant is expected to participate in the study

- Received or plans to receive any live, attenuated vaccine within 4 weeks before the
first dose of study treatment, or during study treatment

Study Contact