Purpose

The purpose of this trial is to assess the efficacy of E7777 in participants with recurrent or persistent Cutaneous T-Cell Lymphoma (CTCL) in Stage I - III participants as assessed by objective response rate (ORR). A lead-in dose-finding part was used to determine dose level 9 microgram per kilogram (mcg/kg) E7777 that is being used to test efficacy and safety.

Condition

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Inclusion Criteria

Participants must meet all of the following criteria to be included in the study:

1. Age greater than or equal to 18 years.

2. Histopathologic diagnosis of CTCL (mycosis fungoides [MF] or Sezary Syndrome [SS]), confirmed by skin biopsy, or lymph node, or blood assessment, of current disease.

3. CD25 assay-positive tumor, defined as detectable CD25 on greater than or equal to 20% of total lymphoid infiltrate in biopsied lesions by immunohistochemistry.

4. CTCL disease stage at study entry as follows, according to ISCL/EORTC (Olsen 2011).

- Lead-In Part: Stage IA - IV, except participants with CNS involvement.

- Main Study: Stage I - III

5. History of prior therapies for CTCL: must have had prior therapy, any number of prior therapies allowed.

Topical treatments (except topical chemotherapy) and steroids are not considered as prior therapies.

6. A minimum washout period of 4 weeks after previous CTCL therapy is recommended before the first dose of E7777.

Participants must have recovered from any adverse effects from any previous CTCL therapy to Common Terminology Criteria for Adverse Events (CTCAE) Grade <2 before starting study drug. A shorter washout may be allowed if participant is experiencing progressive disease despite ongoing treatment.

7. Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 in the Lead-In Part and performance status of 0 or 1 in the Main Study.

8. Life expectancy greater than or equal to 3 months in the Lead-In Part and greater than or equal to 12 months in the Main Study.

9. Adequate bone marrow reserves as evidenced by:

- platelets greater than or equal to 100,000/mm^3 (100 x 10^9/L)

- clinically stable hemoglobin greater than or equal to 9 gram per deciliter (g/dL) (90 g/L) and hematocrit greater than or equal to 27% without transfusion support

10. Normal hepatic function as evidenced by:

- bilirubin <= 1.5* upper limit if normal (ULN) and alkaline phosphatase <=3.0*ULN

- aspartate aminotransferase (AST) and alanine aminotransferase (ALT) <= 3.0*ULN

- albumin >= 3.0 g/dL (30 g/L)

11. Adequate renal function as evidenced by serum creatinine less than or equal to 1.8 mg/dL (158 umol/L) or calculated creatinine clearance greater than or equal to 50 mL/min (per the Cockcroft-Gault formula) with less than 2+ protein or 24- hour urine creatinine clearance greater than or equal to 50 mL/minute with 24- hour urine protein less than 1gram.

12. Provide written informed consent prior to any study-specific screening procedures.

13. Females may not be lactating or pregnant at Screening or Baseline

14. All females will be considered to be of childbearing potential unless they are postmenopausal or have been sterilized surgically

15. Male participants must have had a successful vasectomy (confirmed azoospermia) or they and their female partner must meet the criteria above

Exclusion Criteria

Participants who meet any of the following criteria will be excluded from the study:

1. Prior denileukin diftitox therapy

2. Use of topical steroids within 14 days of Day 1 of initial therapy is not allowed.Topical steroids or systemic low dose steroids of less than or equal to 10 milligram per day (mg/day) prednisone are allowed in participants with erythroderma who have been on corticosteroids for a prolonged period of time and where discontinuation may lead to rebound flare in disease. The concomitant steroid medication is allowed as long as the type of steroid, route of administration, and steroid dose remain the same as what the participant had been receiving for a prolonged period of time.

3. Active malignancy (except for CTCL, definitively treated basal or squamous cell carcinoma of the skin, and carcinoma in-situ of the cervix) within the past 24 months.

4. Serious intercurrent illness

5. Significant cardiac disease requiring ongoing treatment, including congestive heart failure (CHF), severe coronary artery disease (CAD), cardiomyopathy, uncontrolled cardiac arrhythmia, unstable angina pectoris, or myocardial infarction (MI)

6. Significant pulmonary symptoms or disease

7. History of uncontrolled seizure disorder or active central nervous system disease

8. Major surgery within 2 weeks of study enrollment

9. Significant or uncontrolled infections requiring systemic anti-infective therapy

10. Known human immunodeficiency virus (HIV) infection; known active hepatitis B or hepatitis C infection

11. Females who are pregnant (positive urine test) or breastfeeding

12. Any history of a medical condition or a concomitant medical condition that, in the opinion of the investigator, would compromise the participant's ability to safely complete the study.

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
N/A
Intervention Model
Single Group Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
E7777
  • Drug: E7777 9 mcg/kg
    administered by intravenous (i.v.) infusion over 60 minutes (+/-10 minutes) on 5 consecutive days during every cycle of 21 days

Recruiting Locations

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205

City of Hope Medical Center National Medical Center
Duarte, California 91010

University of South Florida College of Medicine
Tampa, Florida 33612

Rush University Medical Center
Chicago, Illinois 60612

Columbia University Medical Center
New York, New York 10032

University of PittsburghMedical Center Presbyterian Shadyside
Pittsburgh, Pennsylvania 15213

The University of TX MD Anderson Cancer Center
Houston, Texas 77030

More Details

NCT ID
NCT01871727
Status
Recruiting
Sponsor
Eisai Inc.

Study Contact

Eisai Medical Information
1-888-274-2378
esi_oncmedinfo@eisai.com

Detailed Description

This is a multicenter, open-label, single-arm study of E7777 in participants with recurrent or persistent CTCL. The study consists of an initial Lead-in part (to select recommended dose of E7777 for Main part), followed by the Main part (to test efficacy). Lead in part is complete and main study is ongoing. Participants will move through three phases while on study: Pretreatment Phase, Treatment Phase, and Extension Phase and a Follow-up Period.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.