Purpose

This randomized phase III trial studies standard or comprehensive radiation therapy in treating patients with early-stage breast cancer who have undergone surgery. Radiation therapy uses high-energy x rays to kill tumor cells. It is not yet known whether comprehensive radiation therapy is more effective than standard radiation therapy in treating patients with breast cancer

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • The patient must have signed and dated an Institutional Review Board (IRB)-approved consent form that conforms to federal and institutional guidelines
  • The patient must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Patient must have clinically T1-3, N1 breast cancer at the time of diagnosis (before neoadjuvant therapy); clinical axillary nodal involvement can be assessed by palpation, ultrasound, CT scan, magnetic resonance imaging (MRI), positron emission tomography (PET) scan, or PET/CT scan
  • Patient must have had pathologic confirmation of axillary nodal involvement at presentation (before neoadjuvant therapy) based on either a positive fine needle aspirate (FNA) (demonstrating malignant cells) or positive core needle biopsy (demonstrating invasive adenocarcinoma); the FNA or core needle biopsy can be performed either by palpation or by image guidance; documentation of axillary nodal positivity by sentinel node biopsy (before neoadjuvant therapy) is not permitted
  • Patients must have had estrogen receptor (ER) analysis performed on the primary breast tumor before neoadjuvant therapy according to current American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for hormone receptor testing; if negative for ER, assessment of progesterone receptor (PgR) must also be performed according to current ASCO/CAP guideline recommendations for hormone receptor testing (http://www.asco.org)
  • Patients must have had HER2 testing performed on the primary breast tumor before neoadjuvant chemotherapy according to the current ASCO/CAP guideline recommendations for human epidermal growth factor receptor 2 testing in Breast Cancer (http://www.asco.org); patients who have a primary tumor that is either HER2-positive or HER2-negative are eligible
  • Patient must have completed a minimum of 8 weeks of standard neoadjuvant chemotherapy consisting of an anthracycline and/or taxane-based regimen
  • For patients who receive adjuvant chemotherapy after surgery, a maximum of 12 weeks of intended chemotherapy may be administered but must be completed before randomization; (if treatment delays occur, chemotherapy must be completed within 14 weeks); the dose and schedule of the adjuvant chemotherapy are at the investigator's discretion; Note: It is preferred that all intended chemotherapy be administered in the neoadjuvant setting
  • Patients with HER2-positive tumors must have received neoadjuvant anti-HER2 therapy (either with all or with a portion of the neoadjuvant chemotherapy regimen), unless medically contraindicated
  • At the time of definitive surgery, all removed axillary nodes must be histologically free from cancer; acceptable procedures for assessment of axillary nodal status at the time of surgery include:
  • Axillary node dissection
  • Sentinel node biopsy alone or
  • Sentinel node biopsy followed by axillary node dissection
  • Note: Patients are eligible whether there is residual invasive carcinoma in the surgical breast specimen or whether there is evidence of pathologic complete response; patients who are found to be pathologically node-positive at the time of surgery, based on sentinel node biopsy alone, are candidates for A011202, a study developed by the Alliance in Oncology, an NCI Cooperative Group; if A011202 is open at the investigator's institution, patients should be approached about participating in the A011202 study
  • Patients with pathologic staging of ypN0(i+) or ypN0(mol+) are eligible (Note: Postneoadjuvant therapy is designated with a "yp" prefix.)
  • Patient who have undergone either a total mastectomy or a lumpectomy are eligible
  • For patients who undergo lumpectomy, the margins of the resected specimen or re-excision must be histologically free of invasive tumor and DCIS as determined by the local pathologist; additional operative procedures may be performed to obtain clear margins; if tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible; (patients with margins positive for lobular carcinoma in situ [LCIS] are eligible without additional resection)
  • For patients who undergo mastectomy, the margins must be histologically free of residual (microscopic or gross) tumor
  • The interval between the last surgery for breast cancer (including re-excision of margins) and randomization must be no more than 70 days; also, if adjuvant chemotherapy was administered, the interval between the last chemotherapy treatment and randomization must be no more than 70 days
  • The patient must have recovered from surgery with the incision completely healed and no signs of infection
  • If adjuvant chemotherapy was administered, chemotherapy-related toxicity that may interfere with delivery of radiation therapy should have resolved

Exclusion Criteria

  • Definitive clinical or radiologic evidence of metastatic disease
  • T4 tumors including inflammatory breast cancer
  • Documentation of axillary nodal positivity before neoadjuvant therapy by sentinel node biopsy alone
  • N2 or N3 disease detected clinically or by imaging
  • Patients with histologically positive axillary nodes post neoadjuvant therapy
  • Patients with microscopic positive margins after definitive surgery
  • Synchronous or previous contralateral invasive breast cancer or DCIS; (patients with synchronous and/or previous contralateral LCIS are eligible)
  • Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy; (patients with synchronous or previous ipsilateral LCIS are eligible)
  • History of non-breast malignancies (except for in situ cancers treated only by local excision and basal cell and squamous cell carcinomas of the skin) within 5 years prior to randomization
  • Any radiation therapy for the currently diagnosed breast cancer prior to randomization
  • Any continued use of sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy; patients are eligible if these medications are discontinued prior to randomization
  • Prior breast or thoracic radiation therapy (RT) for any condition
  • Active collagen vascular disease, specifically dermatomyositis with a creatinine phosphokinase (CPK) level above normal or with an active skin rash, systemic lupus erythematosus, or scleroderma
  • Pregnancy or lactation at the time of study entry; (Note: Pregnancy testing must be performed within 2 weeks prior to randomization according to institutional standards for women of childbearing potential)
  • Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up
  • Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Active Comparator
Group 1A Lumpectomy: no regional nodal XRT with WBI
Lumpectomy patients undergo whole breast radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.
  • Radiation: WBI
    Other names:
    • Whole Breast Irradiation (WBI)
No Intervention
Group 1B Mastectomy: No regional nodal or chestwall XRT
Mastectomy patients do not undergo radiation therapy.
Experimental
Group 2A lumpectomy: Regional nodal XRT with WBI
Lumpectomy patients undergo regional nodal radiation therapy with whole breast radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.
  • Radiation: regional nodal XRT
    Other names:
    • XRT: External radiotherapy
  • Radiation: WBI
    Other names:
    • Whole Breast Irradiation (WBI)
Experimental
Group 2B Mastectomy: Regional nodal XRT and chestwall XRT
Mastectomy patients undergo regional nodal radiation therapy using IMRT or 3D-CRT once daily 5 days a week for 5 weeks.
  • Radiation: regional nodal XRT
    Other names:
    • XRT: External radiotherapy
  • Radiation: chestwall XRT
    Other names:
    • XRT: External radiotherapy

Recruiting Locations

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
Contact:
Jennifer F. De Los Santos
800-828-8816

University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
Contact:
Weisi Yan
251-445-9870
pfrancisco@usouthal.edu

Providence Alaska Medical Center
Anchorage, Alaska 99508
Contact:
Benjamin B. Bridges
208-381-3376
mcdonagd@slhs.org

Arizona Breast Cancer Specialists-Gilbert
Gilbert, Arizona 85297
Contact:
Robert R. Kuske
480-922-4600

Arizona Center for Cancer Care-Peoria
Peoria, Arizona 85381
Contact:
Robert R. Kuske
480-922-4600

Arizona Breast Cancer Specialists-Phoenix
Phoenix, Arizona 85027
Contact:
Robert R. Kuske
480-922-4600

Arizona Breast Cancer Specialists-Scottsdale
Scottsdale, Arizona 85258
Contact:
Robert R. Kuske
480-922-4600

Arizona Center for Cancer Care-Surprise
Surprise, Arizona 85374
Contact:
Robert R. Kuske
480-922-4600

Arizona Oncology Associates-West Orange Grove
Tucson, Arizona 85704
Contact:
Vivek S. Kavadi
281-277-5200

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Contact:
V. S. Klimberg
501-686-8274

Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California 95603
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

Mills - Peninsula Hospitals
Burlingame, California 94010
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California 95682
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

Eden Hospital Medical Center
Castro Valley, California 94546
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

City of Hope Comprehensive Cancer Center
Duarte, California 91010
Contact:
Lily L. Lai
800-826-4673
becomingapatient@coh.org

Epic Care-Dublin
Dublin, California 94568
Contact:
James H. Feusner
510-450-7600

Epic Care Partners in Cancer Care
Emeryville, California 94608
Contact:
James H. Feusner
510-450-7600

California Cancer Center - North Fresno
Fresno, California 93720
Contact:
Uma G. Swamy
559-447-4050

UC San Diego Moores Cancer Center
La Jolla, California 92093
Contact:
Anne Marie D. Wallace
858-822-5354
cancercto@ucsd.edu

City of Hope Antelope Valley
Lancaster, California 93534
Contact:
Lily L. Lai
800-826-4673
becomingapatient@coh.org

Loma Linda University Medical Center
Loma Linda, California 92354
Contact:
Sharon S. Lum
909-558-3375

Los Angeles County-USC Medical Center
Los Angeles, California 90033
Contact:
Naomi R. Schechter
323-865-0451

USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
Contact:
Naomi R. Schechter
323-865-0451

Cedars-Sinai Medical Center
Los Angeles, California 90048
Contact:
Christiane M. Burnison
310-423-8965

Hoag Memorial Hospital
Newport Beach, California 92663
Contact:
Peter V. Chen
949-722-6237
HoagCancerCenter@hoag.org

Alta Bates Summit Medical Center - Summit Campus
Oakland, California 94609
Contact:
James H. Feusner
510-450-7600

Kaiser Permanente Oakland-Broadway
Oakland, California 94611
Contact:
Louis Fehrenbacher
626-564-3455

Saint Joseph Hospital - Orange
Orange, California 92868
Contact:
David A. Margileth
714-734-6220

UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
Contact:
Parima Daroui
877-827-8839
ucstudy@uci.edu

Desert Regional Medical Center
Palm Springs, California 92262
Contact:
Amir Lavaf
760-416-4730

Huntington Memorial Hospital
Pasadena, California 91105
Contact:
Ruth C. Williamson
626-535-2420

Pomona Valley Hospital Medical Center
Pomona, California 91767
Contact:
Yallapragada S. Rao
909-865-9555

Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California 95670
Contact:
Louis Fehrenbacher
626-564-3455

Rohnert Park Cancer Center
Rohnert Park, California 94928
Contact:
Louis Fehrenbacher
626-564-3455

Kaiser Permanente-Roseville
Roseville, California 95661
Contact:
Louis Fehrenbacher
626-564-3455

Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California 95661
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

Sutter Roseville Medical Center
Roseville, California 95661
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California 95678
Contact:
Louis Fehrenbacher
626-564-3455

Sutter General Hospital
Sacramento, California 95816
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
Contact:
Jyoti S. Mayadev
916-734-3089

Saint Helena Hospital
Saint Helena, California 94574
Contact:
Gregory B. Smith
707-967-3698

Naval Medical Center -San Diego
San Diego, California 92134
Contact:
Harvey B. Wilds
619-532-8712

Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
Contact:
Louis Fehrenbacher
626-564-3455

City of Hope South Pasadena
South Pasadena, California 91030
Contact:
Lily L. Lai
800-826-4673
becomingapatient@coh.org

Kaiser Permanente Cancer Treatment Center
South San Francisco, California 94080
Contact:
Louis Fehrenbacher
626-564-3455

Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
Contact:
Jyoti S. Mayadev
916-734-3089

Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville, California 95687
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589
Contact:
Stacy D. D'Andre
415-209-2686
bernicl@sutterhealth.org

Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
Contact:
Keren Sturtz
303-777-2663
ccrp@co-cancerresearch.org

University of Colorado Cancer Center - Anschutz Cancer Pavilion
Aurora, Colorado 80045
Contact:
Rachel A. Rabinovitch
720-848-0650

Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
Contact:
Keren Sturtz
303-777-2663
ccrp@co-cancerresearch.org

Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Contact:
Mehmet S. Copur
800-998-2119

Memorial Hospital Colorado Springs
Colorado Springs, Colorado 80909
Contact:
Rachel A. Rabinovitch
720-848-0650

Porter Adventist Hospital
Denver, Colorado 80210
Contact:
Mehmet S. Copur
800-998-2119

The Shaw Regional Cancer Center
Edwards, Colorado 81632
Contact:
Patricia H. Hardenbergh
970-569-7429

Poudre Valley Hospital
Fort Collins, Colorado 80524
Contact:
Rachel A. Rabinovitch
720-848-0650

Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
Contact:
Keren Sturtz
303-777-2663
ccrp@co-cancerresearch.org

Saint Mary Corwin Medical Center
Pueblo, Colorado 81004
Contact:
Mehmet S. Copur
800-998-2119

Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado 80260
Contact:
Mehmet S. Copur
800-998-2119

SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
Contact:
Keren Sturtz
303-777-2663
ccrp@co-cancerresearch.org

Hartford Hospital
Hartford, Connecticut 06102
Contact:
Helaine F. Bertsch
860-545-5363

Middlesex Hospital
Middletown, Connecticut 06457
Contact:
Susanna Hong
860-358-2058

The Hospital of Central Connecticut
New Britain, Connecticut 06050
Contact:
Neal B. Goldberg
860-224-5660

MedStar Georgetown University Hospital
Washington, District of Columbia 20007
Contact:
Edward C. McCarron
443-777-7364

MedStar Washington Hospital Center
Washington, District of Columbia 20010
Contact:
Edward C. McCarron
443-777-7364

Sibley Memorial Hospital
Washington, District of Columbia 20016
Contact:
Jean L. Wright
202-243-2373

Florida Hospital Cancer Institute Altamonte
Altamonte Springs, Florida 32701
Contact:
Carlos A. Alemany
407-303-2090
FH.Cancer.Research@flhosp.org

John Fitzgerald Kennedy Medical Center
Atlantis, Florida 33462
Contact:
Beth-Ann Lesnikoski
561-964-2662

Morton Plant Hospital
Clearwater, Florida 33756
Contact:
Peter W. Blumencranz
727-461-8519

UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
Contact:
Cristiane Takita
305-243-2647

Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida 33021
Contact:
Srinath Sundararaman
954-265-2234

Jackson Memorial Hospital-Holtz Children's Hospital
Miami, Florida 33136
Contact:
Cristiane Takita
305-243-2647

University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
Contact:
Cristiane Takita
305-243-2647

Florida Hospital Orlando
Orlando, Florida 32803
Contact:
Carlos A. Alemany
407-303-2090
FH.Cancer.Research@flhosp.org

UF Cancer Center at Orlando Health
Orlando, Florida 32806
Contact:
Tomas Dvorak
321-841-7246
CancerClinicalTrials@orlandohealth.com

Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida 33607
Contact:
Robert C. Gabordi
800-882-4123

Moffitt Cancer Center
Tampa, Florida 33612
Contact:
Roberto Diaz
800-456-7121
canceranswers@moffitt.org

Grady Health System
Atlanta, Georgia 30303
Contact:
Mylin A. Torres
404-778-1868

Emory University Hospital Midtown
Atlanta, Georgia 30308
Contact:
Mylin A. Torres
404-778-1868

Piedmont Hospital
Atlanta, Georgia 30309
Contact:
Adam W. Nowlan
404-425-7943
ORS@piedmont.org

Emory University/Winship Cancer Institute
Atlanta, Georgia 30322
Contact:
Mylin A. Torres
404-778-1868

Saint Joseph's Hospital of Atlanta
Atlanta, Georgia 30342
Contact:
Mylin A. Torres
404-778-1868

Tanner Medical Center/Carrollton
Carrollton, Georgia 30117
Contact:
James R. Bland
770-836-9824

Dekalb Medical Center
Decatur, Georgia 30033
Contact:
Sharad A. Ghamande
706-721-1663
cancer@augusta.edu

Memorial University Medical Center
Savannah, Georgia 31404
Contact:
Harvey C. Lebos
912-354-6187

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
Contact:
John A. Pablo
912-819-5704

The Cancer Center of Hawaii-Leeward
'Ewa Beach, Hawaii 96706
Contact:
Kenneth N. Sumida
808-524-6115

Queen's Medical Center
Honolulu, Hawaii 96813
Contact:
Kenneth N. Sumida
808-524-6115

The Cancer Center of Hawaii-Liliha
Honolulu, Hawaii 96817
Contact:
Kenneth N. Sumida
808-524-6115

Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Contact:
Samir Narayan
734-712-4673

Kootenai Cancer Center
Post Falls, Idaho 83854
Contact:
Benjamin T. Marchello
800-648-6274

Mount Sinai Hospital Medical Center
Chicago, Illinois 60608
Contact:
Pam G. Khosla
773-257-5960
suhi@sinai.org

Northwestern University
Chicago, Illinois 60611
Contact:
Eric D. Donnelly
312-695-1301
cancer@northwestern.edu

John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
Contact:
Thomas E. Lad
312-864-6000

University of Illinois
Chicago, Illinois 60612
Contact:
Kent F. Hoskins
312-355-3046

University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
Contact:
Steven J. Chmura
773-834-7424

Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
Contact:
Santosh V. Yajnik
773-296-5360

Decatur Memorial Hospital
Decatur, Illinois 62526
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

AMITA Health Alexian Brothers Medical Center
Elk Grove Village, Illinois 60007
Contact:
Kevin P. McKian
847-952-7164
fredianc@alexian.net

Elmhurst Memorial Hospital
Elmhurst, Illinois 60126
Contact:
Vasudha Lingareddy
630-646-6075

NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
Contact:
Elaine L. Wade
847-570-2109

NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
Contact:
Elaine L. Wade
847-570-2109

Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
Contact:
Elke Aippersbach
800-323-8622

NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
Contact:
Elaine L. Wade
847-570-2109

Presence Saint Mary's Hospital
Kankakee, Illinois 60901
Contact:
Sylvia V. Velinova Falls
815-937-8780

Condell Memorial Hospital
Libertyville, Illinois 60048
Contact:
Dean J. Conterato
630-929-6129
advocateresearch@advocatehealth.com

Loyola University Medical Center
Maywood, Illinois 60153
Contact:
Tarita O. Thomas
708-226-4357

Edward Hospital/Cancer Center
Naperville, Illinois 60540
Contact:
Vasudha Lingareddy
630-646-6075

UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
Contact:
Steven J. Chmura
773-834-7424

Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
Contact:
Paul D. Crossan
800-323-8622
paul.crossan@advocatehealth.com

Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
Contact:
Jacob D. Bitran
847-384-3621

Illinois CancerCare-Peoria
Peoria, Illinois 61615
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria, Illinois 61615
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

OSF Saint Francis Medical Center
Peoria, Illinois 61637
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois 60585
Contact:
Vasudha Lingareddy
630-646-6075

SwedishAmerican Regional Cancer Center/ACT
Rockford, Illinois 61114
Contact:
Harvey E. Einhorn
779-696-9400
cancercare@swedishamerican.org

Memorial Medical Center
Springfield, Illinois 62781
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

Carle Cancer Center
Urbana, Illinois 61801
Contact:
Sinisa Stanic
800-446-5532

Saint Vincent Anderson Regional Hospital/Cancer Center
Anderson, Indiana 46016
Contact:
Alexander M. Yeh
765-646-8358

Parkview Hospital Randallia
Fort Wayne, Indiana 46805
Contact:
Brian K. Chang
260-373-8888
parkviewresearch@parkview.com

Goshen Center for Cancer Care
Goshen, Indiana 46526
Contact:
Laura L. Morris
574-364-2973
cccois@goshenhealth.com

Community Cancer Center East
Indianapolis, Indiana 46219
Contact:
Shih J. Wei
317-497-2823
lcheri@ecommunity.com

Community Cancer Center South
Indianapolis, Indiana 46227
Contact:
Shih J. Wei
317-497-2823
lcheri@ecommunity.com

Franciscan Health Indianapolis
Indianapolis, Indiana 46237
Contact:
Subhash C. Sharma
317-528-7060

Community Cancer Center North
Indianapolis, Indiana 46256
Contact:
Shih J. Wei
317-497-2823
lcheri@ecommunity.com

Saint Vincent Hospital and Health Care Center
Indianapolis, Indiana 46260
Contact:
Alexander M. Yeh
765-646-8358

Memorial Hospital of South Bend
South Bend, Indiana 46601
Contact:
Thomas J. Reid
800-284-7370

Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Contact:
Mehmet S. Copur
800-998-2119

Iowa Methodist Medical Center
Des Moines, Iowa 50309
Contact:
Robert J. Behrens
515-282-2921

Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Contact:
Mehmet S. Copur
800-998-2119

University of Kansas Cancer Center
Kansas City, Kansas 66160
Contact:
Melissa P. Mitchell
913-945-7552
ctnursenav@kumc.edu

University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Contact:
Melissa P. Mitchell
913-945-7552
ctnursenav@kumc.edu

Via Christi Regional Medical Center
Wichita, Kansas 67214
Contact:
Shaker R. Dakhil
316-268-5374

Wesley Medical Center
Wichita, Kansas 67214
Contact:
Shaker R. Dakhil
316-268-5374

Saint Elizabeth Medical Center South
Edgewood, Kentucky 41017
Contact:
Lauren E. Castellini
859-301-5473
darla.hehman@stelizabeth.com

Saint Elizabeth Fort Thomas
Fort Thomas, Kentucky 41075
Contact:
Lauren E. Castellini
859-301-5473
darla.hehman@stelizabeth.com

Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky 40202
Contact:
Mark S. Cornett
502-629-2500

The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky 40202
Contact:
Anthony E. Dragun
866-530-5516

Baptist Health Louisville
Louisville, Kentucky 40207
Contact:
James B. Eckman
859-260-6425

Norton Suburban Hospital and Medical Campus
Louisville, Kentucky 40207
Contact:
Mark S. Cornett
502-629-2500

Owensboro Health Mitchell Memorial Cancer Center
Owensboro, Kentucky 42303
Contact:
Samuel R. Faught
270-688-3691
shawns@omhs.org

Baton Rouge General Medical Center
Baton Rouge, Louisiana 70806
Contact:
Bridgette M. Collins-Burow
504-988-6121

Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809
Contact:
David S. Hanson
225-215-1353
clinicalresearch@marybird.com

Woman's Hospital
Baton Rouge, Louisiana 70817
Contact:
M. G. Fort
225-231-5296
Ericka.Seidemann@womans.org

Mary Bird Cancer Center/Saint Tammany Parish
Covington, Louisiana 70433
Contact:
David S. Hanson
225-215-1353
clinicalresearch@marybird.com

Mary Bird Perkins Cancer Center/Terrebonne General Medical Center
Houma, Louisiana 70360
Contact:
David S. Hanson
225-215-1353
clinicalresearch@marybird.com

Ochsner Medical Center Kenner
Kenner, Louisiana 70065
Contact:
Mini J. Elnaggar
888-562-4763

Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
Contact:
Mini J. Elnaggar
888-562-4763

Eastern Maine Medical Center
Bangor, Maine 04401
Contact:
Thomas H. Openshaw
800-987-3005

Maine Medical Center- Scarborough Campus
Scarborough, Maine 04074
Contact:
Matthew D. Cheney
207-885-7565

Anne Arundel Medical Center
Annapolis, Maryland 21401
Contact:
Mary E. Young
443-481-1320
kbodenhorn@aahs.org

University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
Contact:
Steven J. Feigenberg
800-888-8823

Greater Baltimore Medical Center
Baltimore, Maryland 21204
Contact:
Geoffrey A. Neuner
443-849-3706

MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland 21237
Contact:
Edward C. McCarron
443-777-7364

Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
Contact:
Jean L. Wright
202-243-2373

Central Maryland Radiation Oncology in Howard County
Columbia, Maryland 21044
Contact:
Steven J. Feigenberg
800-888-8823

Tate Cancer Center
Glen Burnie, Maryland 21061
Contact:
Steven J. Feigenberg
800-888-8823

Boston Medical Center
Boston, Massachusetts 02118
Contact:
Ariel E. Hirsch
617-638-8265

Dana-Farber Cancer Institute
Boston, Massachusetts 02215
Contact:
Faina Nakhlis
617-983-7000

Saint Anne's Hospital
Fall River, Massachusetts 02721
Contact:
John L. Yang
508-674-5600

Lowell General Hospital
Lowell, Massachusetts 01854
Contact:
Matthew S. Katz
978-788-7084
ghincks@lowellgeneral.org

Baystate Medical Center
Springfield, Massachusetts 01199
Contact:
Seth A. Kaufman
413-794-9338

Henry Ford Cancer Institute┬┐Downriver
Brownstown, Michigan 48183
Contact:
Thomas J. Doyle
313-916-1784

21st Century Oncology-Clarkston
Clarkston, Michigan 48346
Contact:
Frank A. Vicini
888-326-9729

Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
Contact:
Thomas J. Doyle
313-916-1784

Beaumont Hospital-Dearborn
Dearborn, Michigan 48124
Contact:
Samir Narayan
734-712-4673

Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
Contact:
Jordan M. Maier
313-576-9363

Henry Ford Hospital
Detroit, Michigan 48202
Contact:
Thomas J. Doyle
313-916-1784

Saint John Hospital and Medical Center
Detroit, Michigan 48236
Contact:
Samir Narayan
734-712-4673

Hurley Medical Center
Flint, Michigan 48502
Contact:
Samir Narayan
734-712-4673

Genesys Hurley Cancer Institute
Flint, Michigan 48503
Contact:
Samir Narayan
734-712-4673

McLaren Cancer Institute-Flint
Flint, Michigan 48532
Contact:
Jordan M. Maier
313-576-9363

Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
Contact:
Kathleen J. Yost
616-391-1230
crcwm-regulatory@crcwm.org

Sparrow Hospital
Lansing, Michigan 48912
Contact:
Samir Narayan
734-712-4673

McLaren Cancer Institute-Lapeer Region
Lapeer, Michigan 48446
Contact:
Jordan M. Maier
313-576-9363

McLaren Cancer Institute-Macomb
Mount Clemens, Michigan 48043
Contact:
Jordan M. Maier
313-576-9363

McLaren Cancer Institute-Central Michigan
Mount Pleasant, Michigan 48858
Contact:
Jordan M. Maier
313-576-9363

Mercy Health Mercy Campus
Muskegon, Michigan 49444
Contact:
Kathleen J. Yost
616-391-1230
crcwm-regulatory@crcwm.org

Assarian Cancer Center
Novi, Michigan 48374-1236
Contact:
Cynthia M. Vakhariya
248-849-5337
jaswinder.grewal@stjohn.org

McLaren Cancer Institute-Owosso
Owosso, Michigan 48867
Contact:
Jordan M. Maier
313-576-9363

McLaren Cancer Institute-Northern Michigan
Petoskey, Michigan 49770
Contact:
Jordan M. Maier
313-576-9363

Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
Contact:
Samir Narayan
734-712-4673

William Beaumont Hospital-Royal Oak
Royal Oak, Michigan 48073
Contact:
Nayana S. Dekhne
248-551-7695

Providence Hospital-Southfield Cancer Center
Southfield, Michigan 48075
Contact:
Cynthia M. Vakhariya
248-849-5337
jaswinder.grewal@stjohn.org

21st Century Oncology-Troy
Troy, Michigan 48098
Contact:
Frank A. Vicini
888-326-9729

William Beaumont Hospital - Troy
Troy, Michigan 48098
Contact:
Nayana S. Dekhne
248-551-7695

Saint John Macomb-Oakland Hospital
Warren, Michigan 48093
Contact:
Samir Narayan
734-712-4673

Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
Contact:
Thomas J. Doyle
313-916-1784

Metro Health Hospital
Wyoming, Michigan 49519
Contact:
Kathleen J. Yost
616-391-1230
crcwm-regulatory@crcwm.org

Mayo Clinic Health System in Albert Lea
Albert Lea, Minnesota 56007
Contact:
Robert W. Mutter
855-776-0015

Fairview Ridges Hospital
Burnsville, Minnesota 55337
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

Unity Hospital
Fridley, Minnesota 55432
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

Mayo Clinic Health Systems-Mankato
Mankato, Minnesota 56001
Contact:
Robert W. Mutter
855-776-0015

Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

Mayo Clinic Radiation Therapy-Northfield
Northfield, Minnesota 55057
Contact:
Robert W. Mutter
855-776-0015

Mayo Clinic
Rochester, Minnesota 55905
Contact:
Robert W. Mutter
855-776-0015

Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
Contact:
Donald J. Jurgens
877-229-4907
coborncancercenter@centracare.com

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

Regions Hospital
Saint Paul, Minnesota 55101
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

United Hospital
Saint Paul, Minnesota 55102
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

Ridgeview Medical Center
Waconia, Minnesota 55387
Contact:
Patrick J. Flynn
952-993-1517
mmcorc@parknicollet.com

University of Mississippi Medical Center
Jackson, Mississippi 39216
Contact:
Srinivasan Vijayakumar
601-815-6700

Baptist Memorial Hospital-Desoto
Southhaven, Mississippi 38671
Contact:
Lindi H. VanderWalde
901-226-3077

Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

Saint Luke's Hospital
Chesterfield, Missouri 63017
Contact:
Donald F. Busiek
314-205-6936

University of Missouri - Ellis Fischel
Columbia, Missouri 65212
Contact:
Gregory B. Biedermann
573-882-7440

Barnes-Jewish West County Hospital
Creve Coeur, Missouri 63141
Contact:
Maria A. Thomas
800-600-3606
info@siteman.wustl.edu

Saint Luke's Hospital of Kansas City
Kansas City, Missouri 64111
Contact:
Rakesh Gaur
913-948-5588
aroland@kccop.org

The University of Kansas Cancer Center-South
Kansas City, Missouri 64131
Contact:
Melissa P. Mitchell
913-945-7552
ctnursenav@kumc.edu

Research Medical Center
Kansas City, Missouri 64132
Contact:
Rakesh Gaur
913-948-5588
aroland@kccop.org

The University of Kansas Cancer Center-North
Kansas City, Missouri 64154
Contact:
Melissa P. Mitchell
913-945-7552
ctnursenav@kumc.edu

The University of Kansas Cancer Center-Lee's Summit
Lee's Summit, Missouri 64064
Contact:
Melissa P. Mitchell
913-945-7552
ctnursenav@kumc.edu

Saint Luke's East - Lee's Summit
Lee's Summit, Missouri 64086
Contact:
Rakesh Gaur
913-948-5588
aroland@kccop.org

Washington University School of Medicine
Saint Louis, Missouri 63110
Contact:
Maria A. Thomas
800-600-3606
info@siteman.wustl.edu

Saint Anthony's Medical Center
Saint Louis, Missouri 63128
Contact:
Minxiang (Michael) Gu
888-823-5923
ctsucontact@westat.com

Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Contact:
James L. Wade
217-876-4740
kcheek@dmhhs.org

Siteman Cancer Center - Saint Peters
Saint Peters, Missouri 63376
Contact:
Maria A. Thomas
800-600-3606
info@siteman.wustl.edu

Billings Clinic Cancer Center
Billings, Montana 59101
Contact:
Benjamin T. Marchello
800-648-6274

Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
Contact:
Benjamin T. Marchello
800-648-6274

Kalispell Regional Medical Center
Kalispell, Montana 59901
Contact:
Benjamin T. Marchello
800-648-6274

CHI Health Saint Francis
Grand Island, Nebraska 68803
Contact:
Mehmet S. Copur
800-998-2119

Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska 68124
Contact:
Mehmet S. Copur
800-998-2119

Alegent Health Lakeside Hospital
Omaha, Nebraska 68130
Contact:
Mehmet S. Copur
800-998-2119

University of Nebraska Medical Center
Omaha, Nebraska 68198
Contact:
Andrew O. Wahl
402-559-6941
unmcrsa@unmc.edu

Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
Contact:
John A. Ellerton
702-384-0013

Renown Regional Medical Center
Reno, Nevada 89502
Contact:
Michael C. Hardacre
775-982-4400

Concord Hospital
Concord, New Hampshire 03301
Contact:
Su K. Metcalfe
800-441-1138

Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire 03756
Contact:
Alan C. Hartford
800-639-6918
cancer.research.nurse@dartmouth.edu

Elliot Hospital
Manchester, New Hampshire 03103
Contact:
Brian R. Knab
603-663-1800

Memorial Sloan Kettering Cancer Center at Basking Ridge
Basking Ridge, New Jersey 07920
Contact:
Beryl McCormick
212-639-7202

Ocean Medical Center
Brick, New Jersey 08724
Contact:
Douglas A. Miller
732-206-8384

Cooper Hospital University Medical Center
Camden, New Jersey 08103
Contact:
Ashish B. Patel
856-325-6757

Englewood Hospital and Medical Center
Englewood, New Jersey 07631
Contact:
David M. Dubin
201-894-3456

Saint Barnabas Medical Center
Livingston, New Jersey 07039
Contact:
Alison Grann
973-322-2470

Virtua Memorial
Mount Holly, New Jersey 08060
Contact:
Lemuel S. Ariaratnam
609-914-6762

Jersey Shore Medical Center
Neptune, New Jersey 07753
Contact:
Douglas A. Miller
732-206-8384

Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick, New Jersey 08903
Contact:
Bruce G. Haffty
732-235-8675

The Valley Hospital-Luckow Pavilion
Paramus, New Jersey 07652
Contact:
Laura A. Klein
201-634-5792

Capital Health Medical Center-Hopewell
Pennington, New Jersey 08534
Contact:
Shirnett K. Williamson
800-255-3440

Riverview Medical Center/Booker Cancer Center
Red Bank, New Jersey 07701
Contact:
Douglas A. Miller
732-206-8384

Valley Hospital
Ridgewood, New Jersey 07450
Contact:
Laura A. Klein
201-634-5792

Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey 08876
Contact:
Joel K. Braver
908-685-2481

Sparta Cancer Treatment Center
Sparta, New Jersey 07871
Contact:
Pramila R. Anne
215-955-6084

MD Anderson Cancer Center at Cooper-Voorhees
Voorhees, New Jersey 08043
Contact:
Ashish B. Patel
856-325-6757

Virtua Voorhees
Voorhees, New Jersey 08043
Contact:
Lemuel S. Ariaratnam
609-914-6762

Valley Health System-Hematology/Oncology
Westwood, New Jersey 07675
Contact:
Laura A. Klein
201-634-5792

University of New Mexico Cancer Center
Albuquerque, New Mexico 87102
Contact:
Benny J. Liem
505-925-0366
LByatt@nmcca.org

Lovelace Radiation Oncology
Albuquerque, New Mexico 87109
Contact:
Benny J. Liem
505-925-0366
LByatt@nmcca.org

New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico 87109
Contact:
Benny J. Liem
505-925-0366
LByatt@nmcca.org

Memorial Medical Center - Las Cruces
Las Cruces, New Mexico 88011
Contact:
Benny J. Liem
505-925-0366
LByatt@nmcca.org

Christus Saint Vincent Regional Cancer Center
Santa Fe, New Mexico 87505
Contact:
Benny J. Liem
505-925-0366
LByatt@nmcca.org

Montefiore Medical Center - Moses Campus
Bronx, New York 10467-2490
Contact:
Jana L. Fox
718-904-2730
aecc@aecom.yu.edu

Maimonides Medical Center
Brooklyn, New York 11219
Contact:
David M. Berlach
718-765-2500

Putnam Hospital Center
Carmel, New York 10512
Contact:
Gregory J. Zanieski
845-483-6483

Memorial Sloan Kettering Commack
Commack, New York 11725
Contact:
Beryl McCormick
212-639-7202

Mary Imogene Bassett Hospital
Cooperstown, New York 13326
Contact:
Joy E. Anderson
607-547-3073
diana.crean@bassett.org

Vassar Brothers Fishkill Radiation Oncology Center
Fishkill, New York 12524
Contact:
Gregory J. Zanieski
845-483-6483

Memorial Sloan Kettering Westchester
Harrison, New York 10604
Contact:
Beryl McCormick
212-639-7202

Ulster Radiation Oncology Center
Kingston, New York 12401
Contact:
Gregory J. Zanieski
845-483-6483

Columbia University/Herbert Irving Cancer Center
New York, New York 10032
Contact:
Eileen P. Connolly
212-305-8615

Memorial Sloan-Kettering Cancer Center
New York, New York 10065
Contact:
Beryl McCormick
212-639-7202

Vassar Brothers Medical Center
Poughkeepsie, New York 12601
Contact:
Gregory J. Zanieski
845-483-6483

Rochester General Hospital
Rochester, New York 14621
Contact:
Sheema Chawla
585-922-3536
tia.derosa@rochestergeneral.org

Pluta Cancer Center
Rochester, New York 14623
Contact:
Yuhchyau Chen
585-275-5830

Memorial Sloan Kettering Rockville Centre
Rockville Centre, New York 11570
Contact:
Beryl McCormick
212-639-7202

State University of New York Upstate Medical University
Syracuse, New York 13210
Contact:
Anna Shapiro
315-464-5476

Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
Contact:
Hadley J. Sharp
800-804-9376

Novant Health Presbyterian Medical Center
Charlotte, North Carolina 28204
Contact:
Nasfat Shehadeh
704-384-5369

Carolinas Medical Center/Levine Cancer Institute-Pineville
Charlotte, North Carolina 28210
Contact:
Hadley J. Sharp
704-355-2884

Carolinas Medical Center/Levine Cancer Institute-University
Charlotte, North Carolina 28262
Contact:
Hadley J. Sharp
704-355-2884

Carolinas HealthCare System NorthEast
Concord, North Carolina 28025
Contact:
Hadley J. Sharp
800-804-9376

Duke University Medical Center
Durham, North Carolina 27710
Contact:
Rachel C. Blitzblau
888-275-3853

CaroMont Regional Medical Center
Gastonia, North Carolina 28054
Contact:
Charles J. Meakin
704-834-2932

Cone Health Cancer Center
Greensboro, North Carolina 27403
Contact:
Vinay K. Gudena
336-832-0821

East Carolina University
Greenville, North Carolina 27858
Contact:
Eleanor E. Harris
252-744-2391

Matthews Radiation Oncology Center
Matthews, North Carolina 28105
Contact:
Nasfat Shehadeh
704-384-5369

Carolinas HealthCare System Union
Monroe, North Carolina 28112
Contact:
Hadley J. Sharp
800-804-9376

South Atlantic Radiation Oncology
Supply, North Carolina 28462
Contact:
Michael A. Papagikos
910-251-1839

Coastal Carolina Radiation Oncology
Wilmington, North Carolina 28401
Contact:
Michael A. Papagikos
910-251-1839

Summa Akron City Hospital/Cooper Cancer Center
Akron, Ohio 44304
Contact:
Desiree E. Doncals
330-375-6101

Akron General Medical Center
Akron, Ohio 44307
Contact:
Andrew H. Fenton
330-344-6348

Summa Barberton Hospital
Barberton, Ohio 44203
Contact:
Desiree E. Doncals
330-375-6101

UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio 44122
Contact:
Robert R. Shenk
800-641-2422

Aultman Health Foundation
Canton, Ohio 44710
Contact:
Shruti Trehan
330-363-6891

Geaugra Hospital
Chardon, Ohio 44024
Contact:
Robert R. Shenk
800-641-2422

University of Cincinnati/Barrett Cancer Center
Cincinnati, Ohio 45219
Contact:
Kevin P. Redmond
513-558-4553
uchealthnews@uc.edu

Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
Contact:
Mehmet S. Copur
800-998-2119

Bethesda North Hospital
Cincinnati, Ohio 45242
Contact:
Mehmet S. Copur
800-998-2119

Case Western Reserve University
Cleveland, Ohio 44106
Contact:
Robert R. Shenk
800-641-2422

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
Contact:
Rahul D. Tendulkar
866-223-8100

Cleveland Clinic Foundation
Cleveland, Ohio 44195
Contact:
Rahul D. Tendulkar
866-223-8100

Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Contact:
Julia R. White
800-293-5066
Jamesline@osumc.edu

The Mark H Zangmeister Center
Columbus, Ohio 43219
Contact:
Timothy D. Moore
614-488-2745
sheree@columbusccop.org

Mount Carmel Health Center West
Columbus, Ohio 43222
Contact:
Timothy D. Moore
614-488-2745
sheree@columbusccop.org

Delaware Radiation Oncology
Delaware, Ohio 43015
Contact:
Timothy D. Moore
614-488-2745
sheree@columbusccop.org

Cleveland Clinic Cancer Center Independence
Independence, Ohio 44131
Contact:
Rahul D. Tendulkar
866-223-8100

Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
Contact:
Rahul D. Tendulkar
866-223-8100

Summa Health Center at Lake Medina
Medina, Ohio 44256
Contact:
Desiree E. Doncals
330-375-6101

Lake University Ireland Cancer Center
Mentor, Ohio 44060
Contact:
Robert R. Shenk
800-641-2422

Southwest General Health Center Ireland Cancer Center
Middleburg Heights, Ohio 44130
Contact:
Robert R. Shenk
800-641-2422

University Hospitals Parma Medical Center
Parma, Ohio 44129
Contact:
Robert R. Shenk
800-641-2422

North Coast Cancer Care
Sandusky, Ohio 44870
Contact:
Rahul D. Tendulkar
866-223-8100

Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136
Contact:
Rahul D. Tendulkar
866-223-8100

University Pointe
West Chester, Ohio 45069
Contact:
Kevin P. Redmond
513-558-4553
uchealthnews@uc.edu

UHHS-Westlake Medical Center
Westlake, Ohio 44145
Contact:
Robert R. Shenk
800-641-2422

Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
Contact:
Rahul D. Tendulkar
866-223-8100

Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
Contact:
Terence S. Herman
405-271-8777
ou-clinical-trials@ouhsc.edu

University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Contact:
Terence S. Herman
405-271-8777
ou-clinical-trials@ouhsc.edu

Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
Contact:
Terence S. Herman
405-271-8777
ou-clinical-trials@ouhsc.edu

Willamette Valley Cancer Center
Eugene, Oregon 97401
Contact:
Vivek S. Kavadi
281-277-5200

Compass Oncology Rose Quarter
Portland, Oregon 97227
Contact:
Vivek S. Kavadi
281-277-5200

Kaiser Permanente Northwest
Portland, Oregon 97227
Contact:
Sandeep H. Mashru
503-335-2400

Mid-Columbia Medical Center/Celilo Cancer Center
The Dalles, Oregon 97058
Contact:
Keith J. Stelzer
541-296-7585

Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
Contact:
Samir Narayan
734-712-4673

UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania 15009
Contact:
Sushil Beriwal
412-647-2811

Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania 18015
Contact:
Nimisha Deb
610-954-3582
infolink@slhn.org

Northeast Radiation Oncology Center
Dunmore, Pennsylvania 18512
Contact:
Pramila R. Anne
215-955-6084

Ephrata Cancer Center
Ephrata, Pennsylvania 17522
Contact:
L. Eamonn Boyle
877-441-7957

The Regional Cancer Center
Erie, Pennsylvania 16505
Contact:
Andrew T. Figura
814-838-0448
mhaynes@trcc.org

Fox Chase Cancer Center Buckingham
Furlong, Pennsylvania 18925
Contact:
Bizhan Micaily
215-728-2983

Adams Cancer Center
Gettysburg, Pennsylvania 17325
Contact:
L. Eamonn Boyle
877-441-7957

UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
Contact:
Sushil Beriwal
412-647-2811

PinnacleHealth Cancer Center-Community Campus
Harrisburg, Pennsylvania 17109
Contact:
Joella E. Wilson-Dagar
717-724-6765
klitchfield@PINNACLEHEALTH.org

Penn State Milton S Hershey Medical Center
Hershey, Pennsylvania 17033-0850
Contact:
Jennifer C. Rosenberg
717-531-3779
CTO@hmc.psu.edu

Holy Redeemer Hospital and Medical Center
Meadowbrook, Pennsylvania 19046
Contact:
Sheena K. Jain
215-938-3551

Intercommunity Cancer Center
Monroeville, Pennsylvania 15146
Contact:
Thomas B. Julian
877-284-2000

UPMC-Coraopolis/Heritage Valley Radiation Oncology
Moon, Pennsylvania 15108
Contact:
Sushil Beriwal
412-647-2811

Allegheny Valley Hospital
Natrona Heights, Pennsylvania 15065
Contact:
Thomas B. Julian
877-284-2000

University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania 19104
Contact:
Gary M. Freedman
215-728-4790

Pennsylvania Hospital
Philadelphia, Pennsylvania 19107
Contact:
Gary M. Freedman
215-728-4790

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Contact:
Pramila R. Anne
215-955-6084

Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Contact:
Bizhan Micaily
215-728-2983

Temple University Hospital
Philadelphia, Pennsylvania 19140
Contact:
Bizhan Micaily
215-728-2983

Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
Contact:
Thomas B. Julian
877-284-2000

UPMC-Magee Womens Hospital
Pittsburgh, Pennsylvania 15213
Contact:
Sushil Beriwal
412-647-2811

UPMC-Saint Margaret
Pittsburgh, Pennsylvania 15215
Contact:
Sushil Beriwal
412-647-2811

UPMC-Shadyside Hospital
Pittsburgh, Pennsylvania 15232
Contact:
Sushil Beriwal
412-647-2811

Reading Hospital
West Reading, Pennsylvania 19611
Contact:
Terrence P. Cescon
610-988-9323

Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
Contact:
Thomas B. Julian
877-284-2000

WellSpan Health-York Hospital
York, Pennsylvania 17403
Contact:
L. Eamonn Boyle
877-441-7957

Rhode Island Hospital
Providence, Rhode Island 02903
Contact:
Kara L. Leonard
401-444-1488

Radiation Oncology Associates Incorporated
Providence, Rhode Island 02904
Contact:
Kara L. Leonard
401-444-1488

Women and Infants Hospital
Providence, Rhode Island 02905
Contact:
William M. Sikov
401-274-1122

Kent County Hospital
Warwick, Rhode Island 02886
Contact:
Naveed A. Rana
401-737-7010

Roper Hospital
Charleston, South Carolina 29401
Contact:
Steven A. Akman
843-720-8386
elizabeth.strojny@roperstfrancis.com

Bon Secours Saint Francis Hospital
Charleston, South Carolina 29414
Contact:
Steven A. Akman
843-720-8386
elizabeth.strojny@roperstfrancis.com

Medical University of South Carolina
Charleston, South Carolina 29425
Contact:
Jennifer L. Harper
843-792-9321

Georgetown Hospital System
Georgetown, South Carolina 29440
Contact:
Jennifer L. Harper
843-792-9321

Greenville Health System Cancer Institute-Faris
Greenville, South Carolina 29605
Contact:
David L. Grisell
864-241-6251

Saint Francis Cancer Center
Greenville, South Carolina 29607
Contact:
Robert D. Siegel
864-255-1713

Greenville Health System Cancer Institute-Eastside
Greenville, South Carolina 29615
Contact:
David L. Grisell
864-241-6251

Greenville Health System Cancer Institute-Greer
Greer, South Carolina 29650
Contact:
David L. Grisell
864-241-6251

Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
Contact:
Steven W. Corso
800-486-5941

The Radiation Oncology Center-Hilton Head/Bluffton
Hilton Head Island, South Carolina 29926
Contact:
John A. Pablo
912-819-5704

Greenville Health System Cancer Institute-Seneca
Seneca, South Carolina 29672
Contact:
David L. Grisell
864-241-6251

Spartanburg Medical Center
Spartanburg, South Carolina 29303
Contact:
Steven W. Corso
800-486-5941

Greenville Health System Cancer Institute-Spartanburg
Spartanburg, South Carolina 29307
Contact:
David L. Grisell
864-241-6251

Lexington Medical Center
West Columbia, South Carolina 29169
Contact:
Steven A. Madden
803-936-8050

The West Clinic - Wolf River
Germantown, Tennessee 38138
Contact:
Noam A. VanderWalde
901-516-2579

Thompson Cancer Survival Center
Knoxville, Tennessee 37916
Contact:
Grant M. Clark
865-331-1812

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Contact:
Lindi H. VanderWalde
901-226-3077

Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
Contact:
Anuradha B. Chakravarthy
800-811-8480

Texas Cancer Center
Abilene, Texas 79606
Contact:
Vivek S. Kavadi
281-277-5200

The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106
Contact:
Daniel Arsenault
806-212-1985
gcravey@harringtoncc.org

Texas Oncology-Arlington South
Arlington, Texas 76014
Contact:
Vivek S. Kavadi
281-277-5200

Texas Oncology-Austin Midtown
Austin, Texas 78705
Contact:
Vivek S. Kavadi
281-277-5200

Texas Oncology - Central Austin Cancer Center
Austin, Texas 78731
Contact:
Vivek S. Kavadi
281-277-5200

Texas Oncology - South Austin Cancer Center
Austin, Texas 78745
Contact:
Vivek S. Kavadi
281-277-5200

Texas Oncology Bedford
Bedford, Texas 76022
Contact:
Vivek S. Kavadi
281-277-5200

Parkland Memorial Hospital
Dallas, Texas 75235
Contact:
Ann M. Leitch
214-648-7097

UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
Contact:
Ann M. Leitch
214-648-7097

Texas Oncology-Flower Mound
Flower Mound, Texas 75028
Contact:
Vivek S. Kavadi
281-277-5200

Memorial Hermann Memorial City Medical Center
Houston, Texas 77024
Contact:
Vivek S. Kavadi
281-277-5200

M D Anderson Cancer Center
Houston, Texas 77030
Contact:
Simona F. Shaitelman
713-792-3245

The Methodist Hospital System
Houston, Texas 77030
Contact:
Angel A. Rodriguez
713-790-2700

MD Anderson Regional Care Center-Katy
Houston, Texas 77094
Contact:
Simona F. Shaitelman
713-792-3245

Doctor's Hospital of Laredo
Laredo, Texas 78041
Contact:
Gary W. Unzeitig
888-823-5923
ctsucontact@westat.com

Covenant Medical Center-Lakeside
Lubbock, Texas 79410
Contact:
Ibrahim A. Shalaby
806-725-8000
jaccresearch@covhs.org

University Medical Center
Lubbock, Texas 79415
Contact:
Rakhshanda L. Rahman
806-354-5411

MD Anderson Regional Care Center-Bay Area
Nassau Bay, Texas 77058
Contact:
Simona F. Shaitelman
713-792-3245

Texas Oncology-Plano West
Plano, Texas 75093
Contact:
Vivek S. Kavadi
281-277-5200

Scott and White Healthcare Round Rock
Round Rock, Texas 78665
Contact:
Lucas Wong
254-724-5407

Texas Oncology - Round Rock Cancer Center
Round Rock, Texas 78681
Contact:
Vivek S. Kavadi
281-277-5200

University of Texas Health Science Center at San Antonio
San Antonio, Texas 78229
Contact:
Richard L. Crownover
210-450-3800
CTO@uthscsa.edu

Texas Cancer Center-Sherman
Sherman, Texas 75090
Contact:
Vivek S. Kavadi
281-277-5200

MD Anderson Regional Care Center-Sugar Land
Sugar Land, Texas 77478
Contact:
Simona F. Shaitelman
713-792-3245

Texas Oncology Cancer Center Sugar Land
Sugar Land, Texas 77479
Contact:
Vivek S. Kavadi
281-277-5200

Scott and White Memorial Hospital
Temple, Texas 76508
Contact:
Lucas Wong
254-724-5407

MD Anderson Regional Care Center-The Woodlands
The Woodlands, Texas 77384
Contact:
Simona F. Shaitelman
713-792-3245

Deke Slayton Cancer Center
Webster, Texas 77598
Contact:
Vivek S. Kavadi
281-277-5200

Intermountain Medical Center
Murray, Utah 84107
Contact:
Vilija N. Avizonis
801-507-3950

Utah Valley Regional Medical Center
Provo, Utah 84604
Contact:
Vilija N. Avizonis
801-507-3950

Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
Contact:
Matthew M. Poppe
801-581-4477
clinical.trials@hci.utah.edu

South Jordan Health Center
South Jordan, Utah 84009
Contact:
Matthew M. Poppe
801-581-4477
clinical.trials@hci.utah.edu

Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont 05819
Contact:
Alan C. Hartford
800-639-6918
cancer.research.nurse@dartmouth.edu

Inova Alexandria Hospital
Alexandria, Virginia 22304
Contact:
Jane Grayson
703-776-2580
Stephanie.VanBebber@inova.org

University of Virginia Cancer Center
Charlottesville, Virginia 22908
Contact:
Shayna L. Showalter
434-243-6322
JME3D@hscmail.mcc.virginia.edu

Inova Fairfax Hospital
Falls Church, Virginia 22042
Contact:
Ashish K. Chawla
703-208-6650
Stephanie.VanBebber@inova.org

Augusta Health Cancer Center
Fishersville, Virginia 22939
Contact:
Robert M. Kyler
540-245-7106

Mary Washington Hospital
Fredericksburg, Virginia 22401
Contact:
Harry D. Bear
804-628-1939

Sentara Cancer Institute at Sentara CarePlex Hospital
Hampton, Virginia 23666
Contact:
Mark E. Shaves
757-388-2406

Sentara Norfolk General Hospital
Norfolk, Virginia 23507
Contact:
Mark E. Shaves
757-388-2406

Naval Medical Center - Portsmouth
Portsmouth, Virginia 23708-2197
Contact:
Andrew S. Camarata
757-953-5939

Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
Contact:
Harry D. Bear
804-628-1939

Oncology and Hematology Associates of Southwest Virginia
Roanoke, Virginia 24014
Contact:
Vivek S. Kavadi
281-277-5200

Sentara Virginia Beach General Hospital
Virginia Beach, Virginia 23454
Contact:
Mark E. Shaves
757-388-2406

MultiCare Auburn Medical Center
Auburn, Washington 98001
Contact:
John A. Keech
253-403-2394

Overlake Hospital Medical Center
Bellevue, Washington 98004
Contact:
John A. Keech
253-403-2394

Harrison Medical Center
Bremerton, Washington 98310
Contact:
Mehmet S. Copur
800-998-2119

Virginia Mason Federal Way Medical Center
Federal Way, Washington 98002
Contact:
John A. Keech
253-403-2394

Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Gig Harbor, Washington 98332
Contact:
John A. Keech
253-403-2394

MultiCare Gig Harbor Medical Park
Gig Harbor, Washington 98335
Contact:
John A. Keech
253-403-2394

Tri-Cities Cancer Center
Kennewick, Washington 99336
Contact:
Janice N. Kim
800-804-8824

Skagit Valley Hospital Regional Cancer Care Center
Mount Vernon, Washington 98273
Contact:
Janice N. Kim
800-804-8824

MultiCare Good Samaritan Hospital
Puyallup, Washington 98372
Contact:
John A. Keech
253-403-2394

Tacoma/Valley Radiation Oncology Centers-Puyallup
Puyallup, Washington 98372
Contact:
John A. Keech
253-403-2394

Virginia Mason Medical Center
Seattle, Washington 98101
Contact:
John A. Keech
253-403-2394

Fred Hutchinson Cancer Research Center
Seattle, Washington 98109
Contact:
Janice N. Kim
800-804-8824

Seattle Cancer Care Alliance
Seattle, Washington 98109
Contact:
Janice N. Kim
800-804-8824

University of Washington Medical Center
Seattle, Washington 98195
Contact:
Janice N. Kim
800-804-8824

Cancer Care Northwest - Spokane South
Spokane, Washington 99202
Contact:
Janice N. Kim
800-804-8824

Spokane Valley Cancer Center-Mayfair
Spokane, Washington 99208
Contact:
Janice N. Kim
800-804-8824

MultiCare Tacoma General Hospital
Tacoma, Washington 98405
Contact:
John A. Keech
253-403-2394

Northwest Medical Specialties PLLC
Tacoma, Washington 98405
Contact:
Mehmet S. Copur
800-998-2119

Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Tacoma, Washington 98405
Contact:
John A. Keech
253-403-2394

Compass Oncology Vancouver
Vancouver, Washington 98684
Contact:
Vivek S. Kavadi
281-277-5200

West Virginia University Healthcare
Morgantown, West Virginia 26506
Contact:
Hannah W. Hazard
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Contact:
Hamied R. Rezazadeh
877-405-6866

Fox Valley Surgical Associates Limited
Appleton, Wisconsin 54911
Contact:
Editha (Edie) A. Krueger
920-380-1500

Radiology Associates of Appleton/ThedaCare Regional Medical Center
Appleton, Wisconsin 54911
Contact:
Editha (Edie) A. Krueger
920-380-1500

ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
Contact:
Editha (Edie) A. Krueger
920-380-1500

Sacred Heart Hospital
Eau Claire, Wisconsin 54701
Contact:
Jessica A. Wernberg
715-389-4457

Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Contact:
Ellen L. Ziaja
800-252-2990

Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Contact:
Matthew L. Ryan
920-433-8889

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Contact:
Matthew L. Ryan
920-433-8889

Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Contact:
Ellen L. Ziaja
800-252-2990

UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin 53038
Contact:
Bethany M. Anderson
877-405-6866

Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Contact:
Ellen L. Ziaja
800-252-2990

Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
Contact:
Kurt Oettel
608-775-2385
cancerctr@gundersenhealth.org

Mayo Clinic Health System-Franciscan Healthcare
La Crosse, Wisconsin 54601
Contact:
Robert W. Mutter
855-776-0015

University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
Contact:
Bethany M. Anderson
877-405-6866

Marshfield Clinic
Marshfield, Wisconsin 54449
Contact:
Jessica A. Wernberg
715-389-4457

Saint Joseph's Hospital
Marshfield, Wisconsin 54449
Contact:
Jessica A. Wernberg
715-389-4457

Community Memorial Hospital
Menomonee Falls, Wisconsin 53051
Contact:
Adam D. Currey
414-805-4380

Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Contact:
Ellen L. Ziaja
800-252-2990

Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin 53226
Contact:
Adam D. Currey
414-805-4380

Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Contact:
Ellen L. Ziaja
800-252-2990

Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin 54548
Contact:
Jessica A. Wernberg
715-389-4457

Surgical Associates of Neenah SC
Neenah, Wisconsin 54956
Contact:
Editha (Edie) A. Krueger
920-380-1500

ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Contact:
Wingate F. Clapper
262-928-7632
Chanda.miller@phci.org

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Contact:
Ellen L. Ziaja
800-252-2990

Wheaton Franciscan Cancer Care - All Saints
Racine, Wisconsin 53405
Contact:
James H. Taylor
262-785-2273

Marshfield Clinic-Rice Lake Center
Rice Lake, Wisconsin 54868
Contact:
Jessica A. Wernberg
715-389-4457

Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin 54482
Contact:
Jessica A. Wernberg
715-389-4457

Aurora Medical Center in Summit
Summit, Wisconsin 53066
Contact:
Ellen L. Ziaja
800-252-2990

Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Contact:
Ellen L. Ziaja
800-252-2990

ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
Contact:
Wingate F. Clapper
262-928-7632
Chanda.miller@phci.org

UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Contact:
Wingate F. Clapper
262-928-7632
Chanda.miller@phci.org

Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Contact:
Hamied R. Rezazadeh
877-405-6866

Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
Contact:
Ellen L. Ziaja
800-252-2990

Aurora West Allis Medical Center
West Allis, Wisconsin 53227
Contact:
Ellen L. Ziaja
800-252-2990

The Alyce and Elmore Kraemer Cancer Care Center
West Bend, Wisconsin 53095
Contact:
Adam D. Currey
414-805-4380

Diagnostic and Treatment Center
Weston, Wisconsin 54476
Contact:
Jessica A. Wernberg
715-389-4457

More Details

NCT ID
NCT01872975
Status
Recruiting
Sponsor
NSABP Foundation Inc

Detailed Description

PRIMARY OBJECTIVES:

To evaluate whether the addition of chest wall + regional nodal radiation therapy (XRT) after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for invasive breast cancer recurrence-free interval (IBC-RFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

SECONDARY OBJECTIVES:

I. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly prolong overall survival (OS) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

II. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rates of events for local-regional recurrence-free interval (LRRFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

III. To evaluate whether the addition of chest wall + regional nodal XRT after mastectomy or breast + regional nodal XRT after breast conserving surgery will significantly reduce the rate of events for distant recurrence-free interval (DRFI) in patients who present with histologically positive axillary nodes but convert to histologically negative axillary nodes following neoadjuvant chemotherapy.

IV. To compare the rates of disease-free survival (DFS)-ductal carcinoma in situ (DCIS) by treatment arm.

V. To compare the rates of second primary cancer (SPC) by treatment arm.

VI. To compare the effect of adding XRT on the cosmetic outcomes in mastectomy patients who have had reconstruction.

VII. To compare the effect of adding XRT on quality of life including arm problems, lymphedema, pain, and fatigue.

VIII. To evaluate the toxicity associated with each of the radiation therapy regimens.

IX. To determine whether computed tomography (CT)-based conformal methods (intensity-modulated radiation therapy [IMRT] and 3-dimensional conformal radiation therapy [3DCRT]) for chestwall + regional nodal XRT post mastectomy and regional nodal XRT with breast XRT following breast conserving surgery are feasible in a multi-institutional setting and whether dose-volume analyses can be established to assess treatment adequacy and to develop normal tissue complication probabilities (NTCP) for the likelihood of toxicity.

X. To compare the effect of XRT in patients receiving mastectomy and in patients receiving lumpectomy.

XI. To examine the role of proliferation measures as a prognosticator for patients with residual disease after neoadjuvant chemotherapy.

XII. To develop predictors of the degree of reduction in local regional recurrence (LRR).

OUTLINE: Patients are randomized to 1 of 2 treatment arms.

ARM 1: Patients are assigned to 1 of 2 treatment groups.

GROUP 1A: Lumpectomy patients undergo whole breast radiation therapy using IMRT or 3DCRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.

GROUP 1B: Mastectomy patients do not undergo radiation therapy.

ARM 2: Patients are assigned to 1 of 2 treatment groups.

GROUP 2A: Lumpectomy patients undergo regional nodal radiation therapy with whole breast radiation therapy using IMRT or 3DCRT once daily 5 days a week for 5 weeks followed by a radiation therapy boost to the lumpectomy cavity once daily 5 days a week for 1-1/2 weeks.

GROUP 2B: Mastectomy patients undergo regional nodal radiation therapy and chestwall XRT using IMRT or 3DCRT once daily 5 days a week for 5 weeks.

All patients also receive systemic therapy as planned (hormonal therapy for patients with hormone-receptor positive breast cancer and trastuzumab or other anti-human epidermal growth factor receptor 2 [HER2] therapy for patients with breast cancer that is HER2-positive).

After completion of study treatment, patients are followed up at 6, 12, 18, and 24 months and then yearly for 8 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.