Pegylated Liposomal Doxorubicin Hydrochloride With Atezolizumab and/or Bevacizumab in Treating Patients With Recurrent Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
Purpose
This randomized phase II/III trial studies how well pegylated liposomal doxorubicin hydrochloride with atezolizumab and/or bevacizumab work in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that has come back. Drugs used in chemotherapy, such as pegylated liposomal doxorubicin hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Immunotherapy with monoclonal antibodies, such as atezolizumab and bevacizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. It is not yet known which combination will work better in treating patients with ovarian, fallopian tube, or primary peritoneal cancer.
Conditions
- Fallopian Tube Clear Cell Adenocarcinoma
- Fallopian Tube Endometrioid Adenocarcinoma
- Fallopian Tube Undifferentiated Carcinoma
- High Grade Fallopian Tube Serous Adenocarcinoma
- High Grade Ovarian Serous Adenocarcinoma
- Ovarian Clear Cell Adenocarcinoma
- Ovarian Endometrioid Adenocarcinoma
- Ovarian Seromucinous Carcinoma
- Ovarian Undifferentiated Carcinoma
- Primary Peritoneal High Grade Serous Adenocarcinoma
- Recurrent Fallopian Tube Carcinoma
- Recurrent Ovarian Carcinoma
- Recurrent Primary Peritoneal Carcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients must have the psychological ability and general health that permits completion of the study requirements and required follow up
- Women of child-bearing potential (WOCBP) must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry, for the duration of study participation, and for 5 months (150 days) after the last dose of study agent; should a woman become pregnant or suspect she is pregnant while she is participating in this study, she should inform her treating physician immediately
- Submission of tumor tissue is required for all patients; investigators should check with their site pathology department regarding release of biospecimens before approaching patients about participation in the trial
- High grade ovarian cancer, including high grade serous; clear cell; endometrioid, grade 3; and others (adenocarcinoma, nitric oxide synthase [NOS]; mixed epithelial carcinoma; undifferentiated carcinoma); NOTE: low grade serous, mucinous and carcinosarcoma histologies are excluded; ovarian cancer = ovarian, fallopian tube or primary peritoneal cancer; required data element: submission of pathology report
- Recurrent, platinum resistant ovarian cancer (defined as progression within < 6 months from completion of platinum based therapy; the date should be calculated from the last administered dose of platinum therapy)
- 1-2 prior regimens (including primary therapy); hormonal therapies (e.g., tamoxifen, aromatase inhibitors) will not count toward the prior regimen limit
- Measurable disease (defined by RECIST v. 1.1) or evaluable disease (defined as solid and/or cystic abnormalities on radiographic imaging that do not meet RECIST 1.1 definitions for target lesions OR ascites and/or pleural effusion that has been pathologically demonstrated to be disease related in the setting of cancer antigen [CA]25 >= 2 x upper limit of normal [ULN])
- Performance status 0, 1 or 2
- Absolute neutrophil count (ANC) >= 1,500/mcl (within 14 days prior to registration)
- Platelets >= 100,000/mcl (within 14 days prior to registration)
- Hemoglobin (Hgb) >= 8 g/dl (within 14 days prior to registration)
- Creatinine =< 1.5 x institutional upper limit of normal (ULN) (within 14 days prior to registration)
- Urine protein creatinine (UPC) ratio must be < 1.0 gm (within 14 days prior to registration); if UPC ratio >= 1, collection of 24-hour urine measurement of urine protein is recommended (24-hour urine protein level must be < 1000 mg for patient enrollment); UPC ratio of spot urine is an estimation of the 24-hour urine protein excretion - a UPC ratio of 1 is roughly equivalent to a 24-hour urine protein of 1 gm
- Total bilirubin =< 1.5 x ULN (patients with known Gilbert disease who have serum bilirubin level =< 3 x ULN may be enrolled) (within 14 days prior to registration)
- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 x ULN (AST and/or ALT =< 5 x ULN for patients with liver involvement) (within 14 days prior to registration)
- International normalized ratio (INR) and activated partial thromboplastin time (aPTT) =< 1.5 x ULN (or on stable dose of therapeutic anticoagulation, such as low-molecular-weight heparin, warfarin or rivaroxaban)
- Thyroid-stimulating hormone (TSH) within normal limits (TSH < ULN allowed in euthyroid patients on thyroid replacement therapy)
- The patient or legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information
Exclusion Criteria
- Patients with prior allogeneic bone marrow transplantation or prior solid organ transplantation
- Patients who have had systemic anticancer therapy (e.g., chemotherapy, targeted therapy) within 3 weeks prior to entering the study
- Patients who have had hormonal therapy (e.g., tamoxifen, aromatase inhibitor) within 1 week prior to entering the study
- Patients with prior treatment with anti-programmed cell death (PD)-1, anti- programmed cell death ligand (PD-L)1 or anti-cytotoxic T-lymphocyte-associated protein (CTLA)-4 therapeutic antibody or other similar agents
- Patients with prior treatment with bevacizumab (or any other anti vascular therapy, e.g., cediranib) for platinum resistant recurrence; (Note: prior bevacizumab in initial therapy and/or platinum sensitive recurrent setting is allowed)
- Patients with prior treatment with PLD
- Prior radiotherapy to the abdomen or pelvis
- Patients who have not recovered from adverse events to < grade 1 (other than alopecia) due to agents administered more than 3 weeks earlier; however, the following therapies are allowed:
- Hormone replacement therapy or oral contraceptives
- Herbal therapy > 1 week prior to cycle 1, day 1 (herbal therapy intended as anticancer therapy must be discontinued at least 1 week prior to cycle 1, day 1)
- Palliative radiotherapy for bone metastases > 2 weeks prior to cycle 1, day 1
- Treatment with any other investigational agent within 4 weeks prior to cycle 1, day 1
- Treatment with systemic immunostimulatory agents (including, but not limited to, interferon [IFN]-alpha or interleukin [IL]-2) within 6 weeks prior to cycle 1, day 1
- Treatment with systemic immunosuppressive medications (including, but not limited to, prednisone, cyclophosphamide, azathioprine, methotrexate, thalidomide, and anti-tumor necrosis factor [anti-TNF] agents) within 2 weeks prior to cycle 1, day 1
- Patients who have received acute, low dose, systemic immunosuppressant medications (e.g., a one-time dose of dexamethasone for nausea or steroids as computed tomography [CT] scan contrast premedication) may be enrolled
- The use of inhaled corticosteroids and mineralocorticoids (e.g., fludrocortisone) for patients with orthostatic hypotension or adrenocortical insufficiency is allowed
- Patients taking bisphosphonate therapy for symptomatic hypercalcemia within the past 28 days; use of bisphosphonate therapy for other reasons (e.g., bone metastasis or osteoporosis) is allowed
- Patients with known primary central nervous system (CNS) malignancy or symptomatic CNS metastases are excluded, with the following exceptions:
- Patients with asymptomatic untreated CNS disease may be enrolled, provided all of the following criteria are met:
- Evaluable or measurable disease outside the CNS
- No metastases to brain stem, midbrain, pons, medulla, cerebellum, or within 10 mm of the optic apparatus (optic nerves and chiasm)
- No history of intracranial hemorrhage or spinal cord hemorrhage
- No ongoing requirement for dexamethasone for CNS disease; patients on a stable dose of anticonvulsants are permitted
- No neurosurgical resection or brain biopsy within 28 days prior to cycle 1, day 1
- Patients with asymptomatic treated CNS metastases may be enrolled, provided all the criteria listed above are met as well as the following:
- Radiographic demonstration of improvement upon the completion of CNS directed therapy and no evidence of interim progression between the completion of CNS directed therapy and the screening radiographic study
- No stereotactic radiation or whole-brain radiation within 28 days prior to cycle 1, day 1
- Screening CNS radiographic study >= 4 weeks from completion of radiotherapy and >= 2 weeks from discontinuation of corticosteroids
- Known hypersensitivity to Chinese hamster ovary cell products or other recombinant human antibodies
- History of severe allergic, anaphylactic, or other hypersensitivity reactions to chimeric or humanized antibodies or fusion proteins
- Patients requiring treatment with a receptor activator of nuclear factor kappa-B ligand (RANKL) inhibitor (e.g. denosumab) who cannot discontinue it before treatment with atezolizumab
- Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis; cirrhosis; fatty liver; and inherited liver disease
- Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HBsAg] test and a positive anti-HBc [antibody to hepatitis B core antigen] antibody test) are eligible
- Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV ribonucleic acid (RNA)
- History or risk of autoimmune disease, including but not limited to systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis associated with antiphospholipid syndrome, Wegener's granulomatosis, Sjogren's syndrome, Bell's palsy, Guillain-Barre syndrome, multiple sclerosis, autoimmune thyroid disease, vasculitis, or glomerulonephritis
- Patients with a history of autoimmune hypothyroidism on a stable dose of thyroid replacement hormone are eligible
- Patients with controlled type 1 diabetes mellitus on a stable insulin regimen, or type 2 diabetes mellitus are eligible
- Patients with eczema, psoriasis, lichen simplex chronicus or vitiligo with dermatologic manifestations only (e.g., patients with psoriatic arthritis would be excluded) are permitted provided that they meet the following conditions:
- Patients with psoriasis must have a baseline ophthalmologic exam to rule out ocular manifestations
- Rash must cover less than 10% of body surface area (BSA)
- Disease is well controlled at baseline and only requiring low potency topical steroids (e.g., hydrocortisone 2.5%, hydrocortisone butyrate 0.1%, fluocinolone 0.01%, desonide 0.05%, alclometasone dipropionate 0.05%)
- No acute exacerbations of underlying condition within the last 12 months (not requiring psoralen plus ultraviolet A radiation [PUVA], methotrexate, retinoids, biologic agents, oral calcineurin inhibitors; high potency or oral steroids)
- History of idiopathic pulmonary fibrosis, pneumonitis (including drug induced), organizing pneumonia (i.e., bronchiolitis obliterans, cryptogenic organizing pneumonia, etc.), or evidence of active pneumonitis on screening chest computed tomography (CT) scan; history of radiation pneumonitis in the radiation field (fibrosis) is permitted
- Patients with active tuberculosis (TB) are excluded
- Severe infections within 4 weeks prior to cycle 1, day 1, including but not limited to hospitalization for complications of infection, bacteremia, or severe pneumonia
- Signs or symptoms of infection within 2 weeks prior to cycle 1, day 1
- Received oral or intravenous (IV) antibiotics within 2 weeks prior to cycle 1, day 1; patients receiving prophylactic antibiotics (e.g., for prevention of a urinary tract infection or chronic obstructive pulmonary disease) are eligible
- Major surgical procedure within 28 days prior to cycle 1, day 1 or anticipation of need for a major surgical procedure during the course of the study
- Administration of a live, attenuated vaccine within 4 weeks before cycle 1, day 1 or anticipation that such a live, attenuated vaccine will be required during the study and up to 5 months after the last dose of atezolizumab
- Influenza vaccination should be given during influenza season only (approximately October to March); patients must not receive live, attenuated influenza vaccine within 4 weeks prior to cycle 1, day 1 or at any time during the study
- Uncontrolled intercurrent illness including, but not limited to, ongoing or active infection, symptomatic congestive heart failure, unstable angina pectoris, cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements
- Patients positive for human immunodeficiency virus (HIV) are NOT excluded from this study, but HIV-positive patients must have:
- A stable regimen of highly active anti-retroviral therapy (HAART)
- No requirement for concurrent antibiotics or antifungal agents for the prevention of opportunistic infections
- A cluster of differentiation (CD)4 count above 250 cells/mcL and an undetectable HIV viral load on standard PCR-based tests
- Prior invasive malignancy (except non-melanomatous skin cancer) unless disease free for a minimum of 3 years, with the exception of those with a negligible risk of metastases or death, such as carcinoma in situ of the breast or cervix
- Severe, active co-morbidity defined as follows:
- Current (within 28 days of cycle 1, day 1) signs and/or symptoms of bowel obstruction
- Patients who require parental hydration and/or nutrition
- Patients who require drainage gastrostomy tube
- Evidence of bleeding diathesis or clinically significant coagulopathy
- Serious, non-healing or dehiscing wound, active ulcer or untreated bone fracture
- History of hemoptysis (>= 1/2 teaspoon of bright red blood per episode) within 1 month of study enrollment
- Significant cardiovascular or cerebrovascular disease including:
- Uncontrolled hypertension (systolic blood pressure [SBP] >= 150; diastolic blood pressure [DBP] >= 90)
- History of myocardial infarction within 6 months
- Unstable angina
- New York Heart Association functional classification II, III or IV
- Baseline ejection fraction =< 50% as assessed by echocardiogram or multi-gated acquisition (MUGA)
- Cerebral vascular accident (CVA) or transient ischemic attack (TIA) within 6 months
- Significant vascular disease (e.g., aortic aneurysm, requiring surgical repair or peripheral arterial thrombosis) within 6 months
- History of abdominal/pelvic or tracheoesophageal fistula or gastrointestinal perforation and/or abscess within 6 months prior to initiation of treatment
- Pregnant or lactating patients
Study Design
- Phase
- Phase 2/Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Arm I (PLD, atezolizumab) |
Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1 and atezolizumab IV over 30-60 minutes on days 1 and 15. |
|
|
Experimental Arm II (PLD, bevacizumab, atezolizumab) |
Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1, bevacizumab IV over 30-90 minutes on days 1 and 15, and atezolizumab IV over 30-60 minutes on days 1 and 15. |
|
|
Active Comparator Arm III (PLD, bevacizumab) |
Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1 and bevacizumab IV over 30-90 minutes on days 1 and 15. |
|
Recruiting Locations
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
Anchorage, Alaska 98508
Anchorage Radiation Therapy Center
Anchorage, Alaska 99504
Anchorage, Alaska 99504
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Alaska Women's Cancer Care
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Anchorage Oncology Centre
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Katmai Oncology Group
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Providence Alaska Medical Center
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Fairbanks Memorial Hospital
Fairbanks, Alaska 99701
Fairbanks, Alaska 99701
The University of Arizona Medical Center-University Campus
Tucson, Arizona 85724
Tucson, Arizona 85724
Contact:
Site Public Contact
520-626-9008
Site Public Contact
520-626-9008
CHI Saint Vincent Cancer Center Hot Springs
Hot Springs, Arkansas 71913
Hot Springs, Arkansas 71913
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Kaiser Permanente-Anaheim
Anaheim, California 92806
Anaheim, California 92806
Kaiser Permanente-Deer Valley Medical Center
Antioch, California 94531
Antioch, California 94531
PCR Oncology
Arroyo Grande, California 93420
Arroyo Grande, California 93420
Sutter Auburn Faith Hospital
Auburn, California 95602
Auburn, California 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn, California 95603
Auburn, California 95603
Kaiser Permanente-Baldwin Park
Baldwin Park, California 91706
Baldwin Park, California 91706
Kaiser Permanente-Bellflower
Bellflower, California 90706
Bellflower, California 90706
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
Berkeley, California 94704
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
Burbank, California 91505
Mills-Peninsula Medical Center
Burlingame, California 94010
Burlingame, California 94010
Sutter Cancer Centers Radiation Oncology Services-Cameron Park
Cameron Park, California 95682
Cameron Park, California 95682
Mercy San Juan Medical Center
Carmichael, California 95608
Carmichael, California 95608
Eden Hospital Medical Center
Castro Valley, California 94546
Castro Valley, California 94546
Sutter Davis Hospital
Davis, California 95616
Davis, California 95616
Mercy Cancer Center - Elk Grove
Elk Grove, California 95758
Elk Grove, California 95758
Kaiser Permanente-Fontana
Fontana, California 92335
Fontana, California 92335
Kaiser Permanente-Fremont
Fremont, California 94538
Fremont, California 94538
Palo Alto Medical Foundation-Fremont
Fremont, California 94538
Fremont, California 94538
Fresno Cancer Center
Fresno, California 93720
Fresno, California 93720
Kaiser Permanente-Fresno
Fresno, California 93720
Fresno, California 93720
Marin Cancer Care Inc
Greenbrae, California 94904
Greenbrae, California 94904
Marin General Hospital
Greenbrae, California 94904
Greenbrae, California 94904
Contact:
Site Public Contact
415-925-7325
Site Public Contact
415-925-7325
Kaiser Permanente - Harbor City
Harbor City, California 90710
Harbor City, California 90710
Kaiser Permanente-Irvine
Irvine, California 92618
Irvine, California 92618
Loma Linda University Medical Center
Loma Linda, California 92354
Loma Linda, California 92354
Contact:
Site Public Contact
909-558-3375
Site Public Contact
909-558-3375
Kaiser Permanente Los Angeles Medical Center
Los Angeles, California 90027
Los Angeles, California 90027
Kaiser Permanente-Cadillac
Los Angeles, California 90034
Los Angeles, California 90034
Memorial Medical Center
Modesto, California 95355
Modesto, California 95355
Kaiser Permanente-Modesto
Modesto, California 95356
Modesto, California 95356
Palo Alto Medical Foundation-Camino Division
Mountain View, California 94040
Mountain View, California 94040
Palo Alto Medical Foundation-Gynecologic Oncology
Mountain View, California 94040
Mountain View, California 94040
Sutter Cancer Research Consortium
Novato, California 94945
Novato, California 94945
Kaiser Permanente Oakland-Broadway
Oakland, California 94611
Oakland, California 94611
Kaiser Permanente-Oakland
Oakland, California 94611
Oakland, California 94611
Kaiser Permanente-Ontario
Ontario, California 91761
Ontario, California 91761
Palo Alto Medical Foundation Health Care
Palo Alto, California 94301
Palo Alto, California 94301
Kaiser Permanente - Panorama City
Panorama City, California 91402
Panorama City, California 91402
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California 95670
Rancho Cordova, California 95670
Kaiser Permanente-Redwood City
Redwood City, California 94063
Redwood City, California 94063
Kaiser Permanente-Richmond
Richmond, California 94801
Richmond, California 94801
Kaiser Permanente-Riverside
Riverside, California 92505
Riverside, California 92505
Mercy Cancer Center - Rocklin
Rocklin, California 95765
Rocklin, California 95765
Rohnert Park Cancer Center
Rohnert Park, California 94928
Rohnert Park, California 94928
Kaiser Permanente-Roseville
Roseville, California 95661
Roseville, California 95661
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville, California 95661
Roseville, California 95661
Sutter Roseville Medical Center
Roseville, California 95661
Roseville, California 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California 95678
Roseville, California 95678
Kaiser Permanente Downtown Commons
Sacramento, California 95814
Sacramento, California 95814
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Mercy Cancer Center - Sacramento
Sacramento, California 95816
Sacramento, California 95816
Sutter Medical Center Sacramento
Sacramento, California 95816
Sacramento, California 95816
Kaiser Permanente-South Sacramento
Sacramento, California 95823
Sacramento, California 95823
South Sacramento Cancer Center
Sacramento, California 95823
Sacramento, California 95823
Kaiser Permanente - Sacramento
Sacramento, California 95825
Sacramento, California 95825
Kaiser Permanente-San Diego Mission
San Diego, California 92108
San Diego, California 92108
Kaiser Permanente-San Diego Zion
San Diego, California 92120
San Diego, California 92120
California Pacific Medical Center-Pacific Campus
San Francisco, California 94115
San Francisco, California 94115
Kaiser Permanente-San Francisco
San Francisco, California 94115
San Francisco, California 94115
UCSF Medical Center-Mission Bay
San Francisco, California 94158
San Francisco, California 94158
Contact:
Site Public Contact
877-827-3222
Site Public Contact
877-827-3222
Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
San Jose, California 95119
Kaiser Permanente San Leandro
San Leandro, California 94577
San Leandro, California 94577
Kaiser Permanente-San Marcos
San Marcos, California 92078
San Marcos, California 92078
Kaiser Permanente-San Rafael
San Rafael, California 94903
San Rafael, California 94903
Kaiser San Rafael-Gallinas
San Rafael, California 94903
San Rafael, California 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
Santa Clara, California 95051
Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California 95065
Santa Cruz, California 95065
Kaiser Permanente-Santa Rosa
Santa Rosa, California 95403
Santa Rosa, California 95403
Sutter Pacific Medical Foundation
Santa Rosa, California 95403
Santa Rosa, California 95403
Kaiser Permanente Cancer Treatment Center
South San Francisco, California 94080
South San Francisco, California 94080
Kaiser Permanente-South San Francisco
South San Francisco, California 94080
South San Francisco, California 94080
Kaiser Permanente-Stockton
Stockton, California 95210
Stockton, California 95210
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California 94086
Sunnyvale, California 94086
Sutter Cancer Centers Radiation Oncology Services-Vacaville
Vacaville, California 95687
Vacaville, California 95687
Kaiser Permanente Medical Center-Vacaville
Vacaville, California 95688
Vacaville, California 95688
Kaiser Permanente-Vallejo
Vallejo, California 94589
Vallejo, California 94589
Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589
Vallejo, California 94589
Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
Walnut Creek, California 94596
Kaiser Permanente-Woodland Hills
Woodland Hills, California 91367
Woodland Hills, California 91367
Woodland Memorial Hospital
Woodland, California 95695
Woodland, California 95695
Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
Aurora, Colorado 80012
University of Colorado Hospital
Aurora, Colorado 80045
Aurora, Colorado 80045
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
Boulder Community Hospital
Boulder, Colorado 80301
Boulder, Colorado 80301
Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
Boulder, Colorado 80304
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Colorado Springs, Colorado 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado 80907
Colorado Springs, Colorado 80907
Denver Health Medical Center
Denver, Colorado 80204
Denver, Colorado 80204
Kaiser Permanente-Franklin
Denver, Colorado 80205
Denver, Colorado 80205
National Jewish Health-Main Campus
Denver, Colorado 80206
Denver, Colorado 80206
The Women's Imaging Center
Denver, Colorado 80209
Denver, Colorado 80209
Porter Adventist Hospital
Denver, Colorado 80210
Denver, Colorado 80210
Colorado Blood Cancer Institute
Denver, Colorado 80218
Denver, Colorado 80218
Presbyterian - Saint Lukes Medical Center - Health One
Denver, Colorado 80218
Denver, Colorado 80218
Rocky Mountain Cancer Centers-Midtown
Denver, Colorado 80218
Denver, Colorado 80218
SCL Health Saint Joseph Hospital
Denver, Colorado 80218
Denver, Colorado 80218
Rocky Mountain Cancer Centers-Rose
Denver, Colorado 80220
Denver, Colorado 80220
Western Surgical Care
Denver, Colorado 80220
Denver, Colorado 80220
Mercy Medical Center
Durango, Colorado 81301
Durango, Colorado 81301
Southwest Oncology PC
Durango, Colorado 81301
Durango, Colorado 81301
Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood, Colorado 80113
Englewood, Colorado 80113
Swedish Medical Center
Englewood, Colorado 80113
Englewood, Colorado 80113
Poudre Valley Hospital
Fort Collins, Colorado 80524
Fort Collins, Colorado 80524
Contact:
Site Public Contact
970-297-6150
Site Public Contact
970-297-6150
Mountain Blue Cancer Care Center
Golden, Colorado 80401
Golden, Colorado 80401
National Jewish Health-Western Hematology Oncology
Golden, Colorado 80401
Golden, Colorado 80401
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado 81501
Grand Junction, Colorado 81501
North Colorado Medical Center
Greeley, Colorado 80631
Greeley, Colorado 80631
Good Samaritan Medical Center
Lafayette, Colorado 80026
Lafayette, Colorado 80026
Contact:
Site Public Contact
303-673-1622
Site Public Contact
303-673-1622
Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
Lafayette, Colorado 80026
Rocky Mountain Cancer Centers-Lakewood
Lakewood, Colorado 80228
Lakewood, Colorado 80228
Saint Anthony Hospital
Lakewood, Colorado 80228
Lakewood, Colorado 80228
Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
Littleton, Colorado 80120
Littleton Adventist Hospital
Littleton, Colorado 80122
Littleton, Colorado 80122
Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124
Lone Tree, Colorado 80124
Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
Lone Tree, Colorado 80124
Longmont United Hospital
Longmont, Colorado 80501
Longmont, Colorado 80501
Rocky Mountain Cancer Centers-Longmont
Longmont, Colorado 80501
Longmont, Colorado 80501
McKee Medical Center
Loveland, Colorado 80539
Loveland, Colorado 80539
Parker Adventist Hospital
Parker, Colorado 80138
Parker, Colorado 80138
Rocky Mountain Cancer Centers-Parker
Parker, Colorado 80138
Parker, Colorado 80138
Rocky Mountain Cancer Centers - Pueblo
Pueblo, Colorado 81008
Pueblo, Colorado 81008
National Jewish Health-Northern Hematology Oncology
Thornton, Colorado 80260
Thornton, Colorado 80260
Rocky Mountain Cancer Centers-Thornton
Thornton, Colorado 80260
Thornton, Colorado 80260
SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
Wheat Ridge, Colorado 80033
Beebe Medical Center
Lewes, Delaware 19958
Lewes, Delaware 19958
Delaware Clinical and Laboratory Physicians PA
Newark, Delaware 19713
Newark, Delaware 19713
Helen F Graham Cancer Center
Newark, Delaware 19713
Newark, Delaware 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Newark, Delaware 19713
Regional Hematology and Oncology PA
Newark, Delaware 19713
Newark, Delaware 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
Newark, Delaware 19718
Beebe Health Campus
Rehoboth Beach, Delaware 19971
Rehoboth Beach, Delaware 19971
Nanticoke Memorial Hospital
Seaford, Delaware 19973
Seaford, Delaware 19973
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware 19801
Wilmington, Delaware 19801
Kaiser Permanente-Capitol Hill Medical Center
Washington, District of Columbia 20002
Washington, District of Columbia 20002
Contact:
Site Public Contact
301-548-5743
Site Public Contact
301-548-5743
Emory University Hospital Midtown
Atlanta, Georgia 30308
Atlanta, Georgia 30308
Contact:
Site Public Contact
888-946-7447
Site Public Contact
888-946-7447
Emory University Hospital/Winship Cancer Institute
Atlanta, Georgia 30322
Atlanta, Georgia 30322
Contact:
Site Public Contact
404-778-1868
Site Public Contact
404-778-1868
Emory Saint Joseph's Hospital
Atlanta, Georgia 30342
Atlanta, Georgia 30342
Northside Hospital
Atlanta, Georgia 30342
Atlanta, Georgia 30342
Augusta University Medical Center
Augusta, Georgia 30912
Augusta, Georgia 30912
Northside Hospital-Forsyth
Cumming, Georgia 30041
Cumming, Georgia 30041
Dekalb Medical Center
Decatur, Georgia 30033
Decatur, Georgia 30033
Northeast Georgia Medical Center-Gainesville
Gainesville, Georgia 30501
Gainesville, Georgia 30501
Memorial Health University Medical Center
Savannah, Georgia 31404
Savannah, Georgia 31404
Summit Cancer Care-Memorial
Savannah, Georgia 31404
Savannah, Georgia 31404
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
Savannah, Georgia 31405
Summit Cancer Care-Candler
Savannah, Georgia 31405
Savannah, Georgia 31405
Kaiser Permanente Moanalua Medical Center
Honolulu, Hawaii 96819
Honolulu, Hawaii 96819
Saint Luke's Mountain States Tumor Institute
Boise, Idaho 83712
Boise, Idaho 83712
Kootenai Medical Center
Coeur d'Alene, Idaho 83814
Coeur d'Alene, Idaho 83814
Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho 83619
Fruitland, Idaho 83619
Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, Idaho 83642
Meridian, Idaho 83642
Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, Idaho 83686
Nampa, Idaho 83686
Kootenai Cancer Center
Post Falls, Idaho 83854
Post Falls, Idaho 83854
Kootenai Cancer Clinic
Sandpoint, Idaho 83864
Sandpoint, Idaho 83864
Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, Idaho 83301
Twin Falls, Idaho 83301
Rush - Copley Medical Center
Aurora, Illinois 60504
Aurora, Illinois 60504
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Bloomington, Illinois 61704
Illinois CancerCare-Canton
Canton, Illinois 61520
Canton, Illinois 61520
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
Carbondale, Illinois 62902
SIH Cancer Institute
Carterville, Illinois 62918
Carterville, Illinois 62918
Illinois CancerCare-Carthage
Carthage, Illinois 62321
Carthage, Illinois 62321
Centralia Oncology Clinic
Centralia, Illinois 62801
Centralia, Illinois 62801
Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
Chicago, Illinois 60612
Contact:
Site Public Contact
312-864-5204
Site Public Contact
312-864-5204
Rush University Medical Center
Chicago, Illinois 60612
Chicago, Illinois 60612
University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
Chicago, Illinois 60637
Carle on Vermilion
Danville, Illinois 61832
Danville, Illinois 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Decatur, Illinois 62526
Decatur Memorial Hospital
Decatur, Illinois 62526
Decatur, Illinois 62526
Carle Physician Group-Effingham
Effingham, Illinois 62401
Effingham, Illinois 62401
Crossroads Cancer Center
Effingham, Illinois 62401
Effingham, Illinois 62401
Illinois CancerCare-Eureka
Eureka, Illinois 61530
Eureka, Illinois 61530
NorthShore University HealthSystem-Evanston Hospital
Evanston, Illinois 60201
Evanston, Illinois 60201
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Contact:
Site Public Contact
309-344-2831
Site Public Contact
309-344-2831
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Geneva, Illinois 60134
NorthShore University HealthSystem-Glenbrook Hospital
Glenview, Illinois 60026
Glenview, Illinois 60026
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
NorthShore University HealthSystem-Highland Park Hospital
Highland Park, Illinois 60035
Highland Park, Illinois 60035
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Sudarshan K Sharma MD Limited-Gynecologic Oncology
Hinsdale, Illinois 60521
Hinsdale, Illinois 60521
Contact:
Site Public Contact
630-856-6757
Site Public Contact
630-856-6757
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Kewanee, Illinois 61443
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
Lake Forest, Illinois 60045
Illinois CancerCare-Macomb
Macomb, Illinois 61455
Macomb, Illinois 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Mattoon, Illinois 61938
Loyola University Medical Center
Maywood, Illinois 60153
Maywood, Illinois 60153
Contact:
Site Public Contact
708-226-4357
Site Public Contact
708-226-4357
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois 60160
Melrose Park, Illinois 60160
Contact:
Site Public Contact
708-450-4554
Site Public Contact
708-450-4554
Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
Mount Vernon, Illinois 62864
Contact:
Site Public Contact
618-242-4600
Site Public Contact
618-242-4600
UC Comprehensive Cancer Center at Silver Cross
New Lenox, Illinois 60451
New Lenox, Illinois 60451
University of Chicago Medicine-Orland Park
Orland Park, Illinois 60462
Orland Park, Illinois 60462
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Ottawa, Illinois 61350
Illinois CancerCare-Pekin
Pekin, Illinois 61554
Pekin, Illinois 61554
Illinois CancerCare-Peoria
Peoria, Illinois 61615
Peoria, Illinois 61615
Methodist Medical Center of Illinois
Peoria, Illinois 61636
Peoria, Illinois 61636
Illinois CancerCare-Peru
Peru, Illinois 61354
Peru, Illinois 61354
Valley Radiation Oncology
Peru, Illinois 61354
Peru, Illinois 61354
Contact:
Site Public Contact
815-664-4141
Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton, Illinois 61356
Princeton, Illinois 61356
North Shore Medical Center
Skokie, Illinois 60076
Skokie, Illinois 60076
Southern Illinois University School of Medicine
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Memorial Medical Center
Springfield, Illinois 62781
Springfield, Illinois 62781
Contact:
Site Public Contact
217-788-3528
Site Public Contact
217-788-3528
Cancer Care Specialists of Illinois-Swansea
Swansea, Illinois 62226
Swansea, Illinois 62226
Southwest Illinois Health Services LLP
Swansea, Illinois 62226
Swansea, Illinois 62226
Carle Cancer Center
Urbana, Illinois 61801
Urbana, Illinois 61801
The Carle Foundation Hospital
Urbana, Illinois 61801
Urbana, Illinois 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Warrenville, Illinois 60555
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
Yorkville, Illinois 60560
Parkview Hospital Randallia
Fort Wayne, Indiana 46805
Fort Wayne, Indiana 46805
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
Saint Vincent Hospital and Health Care Center
Indianapolis, Indiana 46260
Indianapolis, Indiana 46260
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa 50325
Clive, Iowa 50325
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Clive, Iowa 50325
Alegent Health Mercy Hospital
Council Bluffs, Iowa 51503
Council Bluffs, Iowa 51503
Greater Regional Medical Center
Creston, Iowa 50801
Creston, Iowa 50801
Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa 50314
Des Moines, Iowa 50314
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Des Moines, Iowa 50314
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Iowa City, Iowa 52242
Contact:
Site Public Contact
800-237-1225
Site Public Contact
800-237-1225
Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
West Des Moines, Iowa 50266
Coffeyville Regional Medical Center
Coffeyville, Kansas 67337
Coffeyville, Kansas 67337
Contact:
Site Public Contact
620-252-1606
Site Public Contact
620-252-1606
Hays Medical Center
Hays, Kansas 67601
Hays, Kansas 67601
Contact:
Site Public Contact
785-623-5774
Site Public Contact
785-623-5774
University of Kansas Cancer Center
Kansas City, Kansas 66160
Kansas City, Kansas 66160
Olathe Medical Center
Olathe, Kansas 66061
Olathe, Kansas 66061
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Overland Park, Kansas 66210
University of Kansas Hospital-Indian Creek Campus
Overland Park, Kansas 66211
Overland Park, Kansas 66211
Via Christi Hospital-Pittsburg
Pittsburg, Kansas 66762
Pittsburg, Kansas 66762
Contact:
Site Public Contact
620-235-7900
Site Public Contact
620-235-7900
Salina Regional Health Center
Salina, Kansas 67401
Salina, Kansas 67401
Saint Francis Hospital and Medical Center - Topeka
Topeka, Kansas 66606
Topeka, Kansas 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
Westwood, Kansas 66205
Flaget Memorial Hospital
Bardstown, Kentucky 40004
Bardstown, Kentucky 40004
Baptist Health Corbin
Corbin, Kentucky 40701
Corbin, Kentucky 40701
Contact:
Site Public Contact
859-523-1934
Site Public Contact
859-523-1934
Commonwealth Cancer Center-Corbin
Corbin, Kentucky 40701
Corbin, Kentucky 40701
Saint Elizabeth Medical Center South
Edgewood, Kentucky 41017
Edgewood, Kentucky 41017
Baptist Health Lexington
Lexington, Kentucky 40503
Lexington, Kentucky 40503
Contact:
Site Public Contact
859-260-6425
Site Public Contact
859-260-6425
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky 40504
Lexington, Kentucky 40504
Saint Joseph Hospital East
Lexington, Kentucky 40509
Lexington, Kentucky 40509
Saint Joseph London
London, Kentucky 40741
London, Kentucky 40741
Jewish Hospital
Louisville, Kentucky 40202
Louisville, Kentucky 40202
Norton Hospital Pavilion and Medical Campus
Louisville, Kentucky 40202
Louisville, Kentucky 40202
Contact:
Site Public Contact
502-629-2500
Site Public Contact
502-629-2500
Baptist Health Louisville
Louisville, Kentucky 40207
Louisville, Kentucky 40207
Norton Suburban Hospital and Medical Campus
Louisville, Kentucky 40207
Louisville, Kentucky 40207
Contact:
Site Public Contact
502-629-3465
Site Public Contact
502-629-3465
Saints Mary and Elizabeth Hospital
Louisville, Kentucky 40215
Louisville, Kentucky 40215
Norton Brownsboro Hospital and Medical Campus
Louisville, Kentucky 40241
Louisville, Kentucky 40241
Jewish Hospital Medical Center Northeast
Louisville, Kentucky 40245
Louisville, Kentucky 40245
Baptist Health Madisonville/Merle Mahr Cancer Center
Madisonville, Kentucky 42431
Madisonville, Kentucky 42431
Contact:
Site Public Contact
800-733-2312
Site Public Contact
800-733-2312
Baptist Health Paducah
Paducah, Kentucky 42003
Paducah, Kentucky 42003
Contact:
Site Public Contact
270-575-2928
Site Public Contact
270-575-2928
Jewish Hospital Medical Center South
Shepherdsville, Kentucky 40165
Shepherdsville, Kentucky 40165
Baton Rouge General Medical Center
Baton Rouge, Louisiana 70806
Baton Rouge, Louisiana 70806
Contact:
Site Public Contact
225-381-6451
Site Public Contact
225-381-6451
Hematology/Oncology Clinic LLP
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Contact:
Site Public Contact
225-767-0822
Site Public Contact
225-767-0822
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Women's Cancer Care-Covington
Covington, Louisiana 70433
Covington, Louisiana 70433
Tulane University Health Sciences Center
New Orleans, Louisiana 70112
New Orleans, Louisiana 70112
Contact:
Site Public Contact
504-988-6121
Site Public Contact
504-988-6121
Ochsner Baptist Medical Center
New Orleans, Louisiana 70115
New Orleans, Louisiana 70115
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
New Orleans, Louisiana 70121
Eastern Maine Medical Center
Bangor, Maine 04401
Bangor, Maine 04401
Contact:
Site Public Contact
207-973-4274
Site Public Contact
207-973-4274
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Brewer, Maine 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
Maine Medical Center- Scarborough Campus
Scarborough, Maine 04074
Scarborough, Maine 04074
Greater Baltimore Medical Center
Baltimore, Maryland 21204
Baltimore, Maryland 21204
Contact:
Site Public Contact
443-849-3706
Site Public Contact
443-849-3706
Kaiser Permanente-Woodlawn Medical Center
Baltimore, Maryland 21244
Baltimore, Maryland 21244
Contact:
Site Public Contact
301-816-7218
Site Public Contact
301-816-7218
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
Baltimore, Maryland 21287
The Memorial Hospital at Easton
Easton, Maryland 21601
Easton, Maryland 21601
Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg, Maryland 20879
Gaithersburg, Maryland 20879
Contact:
Site Public Contact
301-816-7218
Site Public Contact
301-816-7218
Kaiser Permanente - Kensington Medical Center
Kensington, Maryland 20895
Kensington, Maryland 20895
Contact:
Site Public Contact
301-816-7218
Site Public Contact
301-816-7218
Kaiser Permanente - Largo Medical Center
Largo, Maryland 20774
Largo, Maryland 20774
Contact:
Site Public Contact
301-816-7446
Site Public Contact
301-816-7446
Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
Burlington, Massachusetts 01805
Contact:
Site Public Contact
781-744-8027
Site Public Contact
781-744-8027
Baystate Medical Center
Springfield, Massachusetts 01199
Springfield, Massachusetts 01199
Winchester Hospital
Winchester, Massachusetts 01890
Winchester, Massachusetts 01890
Bronson Battle Creek
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
Henry Ford Cancer Institute¿Downriver
Brownstown, Michigan 48183
Brownstown, Michigan 48183
Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
Clinton Township, Michigan 48038
Contact:
Site Public Contact
313-916-1784
Site Public Contact
313-916-1784
Henry Ford Medical Center-Fairlane
Dearborn, Michigan 48126
Dearborn, Michigan 48126
Contact:
Site Public Contact
888-734-5322
Site Public Contact
888-734-5322
Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
Detroit, Michigan 48201
Henry Ford Hospital
Detroit, Michigan 48202
Detroit, Michigan 48202
Contact:
Site Public Contact
313-916-1784
Site Public Contact
313-916-1784
Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
Farmington Hills, Michigan 48334
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Mercy Health Saint Mary's
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Allegiance Health
Jackson, Michigan 49201
Jackson, Michigan 49201
Contact:
Site Public Contact
517-788-4800
Site Public Contact
517-788-4800
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
West Michigan Cancer Center
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
Borgess Medical Center
Kalamazoo, Michigan 49048
Kalamazoo, Michigan 49048
Mercy Health Mercy Campus
Muskegon, Michigan 49444
Muskegon, Michigan 49444
Lakeland Hospital Niles
Niles, Michigan 49120
Niles, Michigan 49120
Henry Ford Medical Center-Columbus
Novi, Michigan 48377
Novi, Michigan 48377
Contact:
Site Public Contact
888-734-5322
Site Public Contact
888-734-5322
Huron Medical Center PC
Port Huron, Michigan 48060
Port Huron, Michigan 48060
Spectrum Health Reed City Hospital
Reed City, Michigan 49677
Reed City, Michigan 49677
Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
West Bloomfield, Michigan 48322
Contact:
Site Public Contact
888-734-5322
Site Public Contact
888-734-5322
Metro Health Hospital
Wyoming, Michigan 49519
Wyoming, Michigan 49519
Sanford Clinic North-Bemidgi
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
Contact:
Site Public Contact
218-333-5000
Site Public Contact
218-333-5000
Fairview Ridges Hospital
Burnsville, Minnesota 55337
Burnsville, Minnesota 55337
Mercy Hospital
Coon Rapids, Minnesota 55433
Coon Rapids, Minnesota 55433
Fairview-Southdale Hospital
Edina, Minnesota 55435
Edina, Minnesota 55435
Unity Hospital
Fridley, Minnesota 55432
Fridley, Minnesota 55432
Fairview Maple Grove Medical Center
Maple Grove, Minnesota 55369
Maple Grove, Minnesota 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
Maplewood, Minnesota 55109
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
Maplewood, Minnesota 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
Minneapolis, Minnesota 55407
Hennepin County Medical Center
Minneapolis, Minnesota 55415
Minneapolis, Minnesota 55415
Health Partners Inc
Minneapolis, Minnesota 55454
Minneapolis, Minnesota 55454
Monticello Cancer Center
Monticello, Minnesota 55362
Monticello, Minnesota 55362
New Ulm Medical Center
New Ulm, Minnesota 56073
New Ulm, Minnesota 56073
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
Robbinsdale, Minnesota 55422
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
Saint Louis Park, Minnesota 55416
Regions Hospital
Saint Paul, Minnesota 55101
Saint Paul, Minnesota 55101
United Hospital
Saint Paul, Minnesota 55102
Saint Paul, Minnesota 55102
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
Shakopee, Minnesota 55379
Lakeview Hospital
Stillwater, Minnesota 55082
Stillwater, Minnesota 55082
Ridgeview Medical Center
Waconia, Minnesota 55387
Waconia, Minnesota 55387
Rice Memorial Hospital
Willmar, Minnesota 56201
Willmar, Minnesota 56201
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
Woodbury, Minnesota 55125
Sanford Cancer Center Worthington
Worthington, Minnesota 56187
Worthington, Minnesota 56187
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
Wyoming, Minnesota 55092
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri 63011
Ballwin, Missouri 63011
Contact:
Site Public Contact
314-251-7058
Site Public Contact
314-251-7058
Parkland Health Center-Bonne Terre
Bonne Terre, Missouri 63628
Bonne Terre, Missouri 63628
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Cox Cancer Center Branson
Branson, Missouri 65616
Branson, Missouri 65616
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
Southeast Cancer Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
Contact:
Site Public Contact
573-651-5550
Site Public Contact
573-651-5550
Capital Region Southwest Campus
Jefferson City, Missouri 65109
Jefferson City, Missouri 65109
Freeman Health System
Joplin, Missouri 64804
Joplin, Missouri 64804
Mercy Hospital Joplin
Joplin, Missouri 64804
Joplin, Missouri 64804
Truman Medical Center
Kansas City, Missouri 64108
Kansas City, Missouri 64108
Contact:
Site Public Contact
816-404-4375
Site Public Contact
816-404-4375
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri 65401
Rolla, Missouri 65401
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
Rolla, Missouri 65401
Heartland Regional Medical Center
Saint Joseph, Missouri 64507
Saint Joseph, Missouri 64507
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
Saint Louis, Missouri 63109
Contact:
Site Public Contact
314-353-1870
Site Public Contact
314-353-1870
Washington University School of Medicine
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
Saint Louis, Missouri 63141
Contact:
Site Public Contact
314-251-6770
Site Public Contact
314-251-6770
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
Sainte Genevieve, Missouri 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield, Missouri 65804
Springfield, Missouri 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield, Missouri 65807
Springfield, Missouri 65807
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
Sullivan, Missouri 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Missouri Baptist Outpatient Center-Sunset Hills
Sunset Hills, Missouri 63127
Sunset Hills, Missouri 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Washington
Washington, Missouri 63090
Washington, Missouri 63090
Contact:
Site Public Contact
636-390-1600
Site Public Contact
636-390-1600
Community Hospital of Anaconda
Anaconda, Montana 59711
Anaconda, Montana 59711
Billings Clinic Cancer Center
Billings, Montana 59101
Billings, Montana 59101
Saint Vincent Healthcare
Billings, Montana 59101
Billings, Montana 59101
Saint Vincent Frontier Cancer Center
Billings, Montana 59102
Billings, Montana 59102
Contact:
Site Public Contact
800-648-6274
Site Public Contact
800-648-6274
Bozeman Deaconess Hospital
Bozeman, Montana 59715
Bozeman, Montana 59715
Saint James Community Hospital and Cancer Treatment Center
Butte, Montana 59701
Butte, Montana 59701
Contact:
Site Public Contact
406-723-2621
Site Public Contact
406-723-2621
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
Great Falls, Montana 59405
Great Falls Clinic
Great Falls, Montana 59405
Great Falls, Montana 59405
Saint Peter's Community Hospital
Helena, Montana 59601
Helena, Montana 59601
Kalispell Regional Medical Center
Kalispell, Montana 59901
Kalispell, Montana 59901
Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
Missoula, Montana 59802
Community Medical Hospital
Missoula, Montana 59804
Missoula, Montana 59804
CHI Health Saint Francis
Grand Island, Nebraska 68803
Grand Island, Nebraska 68803
Heartland Hematology and Oncology
Kearney, Nebraska 68845
Kearney, Nebraska 68845
CHI Health Good Samaritan
Kearney, Nebraska 68847
Kearney, Nebraska 68847
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska 68510
Lincoln, Nebraska 68510
Nebraska Methodist Hospital
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Contact:
Site Public Contact
402-354-5144
Site Public Contact
402-354-5144
Alegent Health Immanuel Medical Center
Omaha, Nebraska 68122
Omaha, Nebraska 68122
Hematology and Oncology Consultants PC
Omaha, Nebraska 68122
Omaha, Nebraska 68122
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska 68124
Omaha, Nebraska 68124
Alegent Health Lakeside Hospital
Omaha, Nebraska 68130
Omaha, Nebraska 68130
Creighton University Medical Center
Omaha, Nebraska 68131
Omaha, Nebraska 68131
Midlands Community Hospital
Papillion, Nebraska 68046
Papillion, Nebraska 68046
Carson Tahoe Regional Medical Center
Carson City, Nevada 89703
Carson City, Nevada 89703
Cancer and Blood Specialists-Henderson
Henderson, Nevada 89052
Henderson, Nevada 89052
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada 89052
Henderson, Nevada 89052
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
Henderson, Nevada 89052
Las Vegas Cancer Center-Henderson
Henderson, Nevada 89052
Henderson, Nevada 89052
Nevada Cancer Specialists-Saint Rose
Henderson, Nevada 89052
Henderson, Nevada 89052
21st Century Oncology-Henderson
Henderson, Nevada 89074
Henderson, Nevada 89074
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
Henderson, Nevada 89074
Desert West Surgery
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
Nevada Cancer Specialists?Oakey
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
University Medical Center of Southern Nevada
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
Hope Cancer Care of Nevada
Las Vegas, Nevada 89103
Las Vegas, Nevada 89103
Cancer and Blood Specialists-Shadow
Las Vegas, Nevada 89106
Las Vegas, Nevada 89106
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
Las Vegas, Nevada 89106
21st Century Oncology
Las Vegas, Nevada 89109
Las Vegas, Nevada 89109
HealthCare Partners Medical Group Oncology/Hematology-Maryland Parkway
Las Vegas, Nevada 89109
Las Vegas, Nevada 89109
HealthCare Partners Medical Group Oncology/Hematology-San Martin
Las Vegas, Nevada 89113
Las Vegas, Nevada 89113
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada 89119
Las Vegas, Nevada 89119
Cancer Therapy and Integrative Medicine
Las Vegas, Nevada 89121
Las Vegas, Nevada 89121
21st Century Oncology-Vegas Tenaya
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Ann M Wierman MD LTD
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Cancer and Blood Specialists-Tenaya
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
HealthCare Partners Medical Group Oncology/Hematology-Tenaya
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Nevada Cancer Specialists-Tenaya
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
Las Vegas, Nevada 89144
Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
Las Vegas, Nevada 89144
Las Vegas Cancer Center-Medical Center
Las Vegas, Nevada 89148-2405
Las Vegas, Nevada 89148-2405
21st Century Oncology-Fort Apache
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
Nevada Cancer Specialists-Fort Apache
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
HealthCare Partners Medical Group Oncology/Hematology-Centennial Hills
Las Vegas, Nevada 89149
Las Vegas, Nevada 89149
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada 89169
Las Vegas, Nevada 89169
University Cancer Center
Las Vegas, Nevada 89169
Las Vegas, Nevada 89169
Women's Cancer Center of Nevada
Las Vegas, Nevada 89169
Las Vegas, Nevada 89169
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada 89048
Pahrump, Nevada 89048
Renown Regional Medical Center
Reno, Nevada 89502
Reno, Nevada 89502
Saint Mary's Regional Medical Center
Reno, Nevada 89503
Reno, Nevada 89503
Radiation Oncology Associates
Reno, Nevada 89509
Reno, Nevada 89509
Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire 03756
Lebanon, New Hampshire 03756
Norris Cotton Cancer Center-Nashua
Nashua, New Hampshire 03063
Nashua, New Hampshire 03063
Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey 07920
Basking Ridge, New Jersey 07920
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Hackensack University Medical Center
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
Contact:
Site Public Contact
201-996-2879
Site Public Contact
201-996-2879
Memorial Sloan Kettering Monmouth
Middletown, New Jersey 07748
Middletown, New Jersey 07748
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
University of New Mexico Cancer Center
Albuquerque, New Mexico 87102
Albuquerque, New Mexico 87102
Southwest Gynecologic Oncology Associates Inc
Albuquerque, New Mexico 87106
Albuquerque, New Mexico 87106
Women's Cancer Care Associates LLC
Albany, New York 12208
Albany, New York 12208
Roswell Park Cancer Institute
Buffalo, New York 14263
Buffalo, New York 14263
Memorial Sloan Kettering Commack
Commack, New York 11725
Commack, New York 11725
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Memorial Sloan Kettering Westchester
Harrison, New York 10604
Harrison, New York 10604
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Mount Sinai Chelsea
New York, New York 10011
New York, New York 10011
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
New York, New York 10016
Mount Sinai Hospital
New York, New York 10029
New York, New York 10029
Memorial Sloan Kettering Cancer Center
New York, New York 10065
New York, New York 10065
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
University of Rochester
Rochester, New York 14642
Rochester, New York 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
Memorial Sloan Kettering Rockville Centre
Rockville Centre, New York 11570
Rockville Centre, New York 11570
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
State University of New York Upstate Medical University
Syracuse, New York 13210
Syracuse, New York 13210
Contact:
Site Public Contact
315-464-5476
Site Public Contact
315-464-5476
SUNY Upstate Medical Center-Community Campus
Syracuse, New York 13215
Syracuse, New York 13215
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
Chapel Hill, North Carolina 27599
Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
Charlotte, North Carolina 28203
Contact:
Site Public Contact
704-355-2884
Site Public Contact
704-355-2884
Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328
Clinton, North Carolina 28328
Carolinas HealthCare System NorthEast
Concord, North Carolina 28025
Concord, North Carolina 28025
Contact:
Site Public Contact
704-403-1520
Site Public Contact
704-403-1520
Duke University Medical Center
Durham, North Carolina 27710
Durham, North Carolina 27710
Contact:
Site Public Contact
888-275-3853
Site Public Contact
888-275-3853
Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534
Goldsboro, North Carolina 27534
Wayne Memorial Hospital
Goldsboro, North Carolina 27534
Goldsboro, North Carolina 27534
Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
Hendersonville, North Carolina 28791
Onslow Memorial Hospital
Jacksonville, North Carolina 28546
Jacksonville, North Carolina 28546
Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546
Jacksonville, North Carolina 28546
Duke Raleigh Hospital
Raleigh, North Carolina 27609
Raleigh, North Carolina 27609
Contact:
Site Public Contact
919-862-5400
Site Public Contact
919-862-5400
New Hanover Regional Medical Center/Zimmer Cancer Center
Wilmington, North Carolina 28401
Wilmington, North Carolina 28401
Contact:
Site Public Contact
910-342-3000
Site Public Contact
910-342-3000
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
Sanford South University Medical Center
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Contact:
Site Public Contact
701-234-6161
Site Public Contact
701-234-6161
Roger Maris Cancer Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Contact:
Site Public Contact
701-234-6161
Site Public Contact
701-234-6161
Sanford Broadway Medical Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Contact:
Site Public Contact
800-437-4010
Site Public Contact
800-437-4010
UHHS-Chagrin Highlands Medical Center
Beachwood, Ohio 44122
Beachwood, Ohio 44122
Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
Beavercreek, Ohio 45431
Strecker Cancer Center-Belpre
Belpre, Ohio 45714
Belpre, Ohio 45714
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
Centerville, Ohio 45459
Miami Valley Hospital South
Centerville, Ohio 45459
Centerville, Ohio 45459
Geauga Hospital
Chardon, Ohio 44024
Chardon, Ohio 44024
Adena Regional Medical Center
Chillicothe, Ohio 45601
Chillicothe, Ohio 45601
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
Cincinnati, Ohio 45220
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio 45236
Cincinnati, Ohio 45236
Bethesda North Hospital
Cincinnati, Ohio 45242
Cincinnati, Ohio 45242
TriHealth Cancer Institute-Westside
Cincinnati, Ohio 45247
Cincinnati, Ohio 45247
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio 45255
Cincinnati, Ohio 45255
Case Western Reserve University
Cleveland, Ohio 44106
Cleveland, Ohio 44106
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
Cleveland, Ohio 44111
Cleveland Clinic Foundation
Cleveland, Ohio 44195
Cleveland, Ohio 44195
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Columbus, Ohio 43210
Mount Carmel East Hospital
Columbus, Ohio 43213
Columbus, Ohio 43213
Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
Columbus, Ohio 43214
Riverside Methodist Hospital
Columbus, Ohio 43214
Columbus, Ohio 43214
Grant Medical Center
Columbus, Ohio 43215
Columbus, Ohio 43215
The Mark H Zangmeister Center
Columbus, Ohio 43219
Columbus, Ohio 43219
Mount Carmel Health Center West
Columbus, Ohio 43222
Columbus, Ohio 43222
Doctors Hospital
Columbus, Ohio 43228
Columbus, Ohio 43228
Good Samaritan Hospital - Dayton
Dayton, Ohio 45406
Dayton, Ohio 45406
Miami Valley Hospital
Dayton, Ohio 45409
Dayton, Ohio 45409
Dayton Physicians LLC-Samaritan North
Dayton, Ohio 45415
Dayton, Ohio 45415
Samaritan North Health Center
Dayton, Ohio 45415
Dayton, Ohio 45415
Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
Delaware, Ohio 43015
Delaware Radiation Oncology
Delaware, Ohio 43015
Delaware, Ohio 43015
Grady Memorial Hospital
Delaware, Ohio 43015
Delaware, Ohio 43015
Mercy Cancer Center-Elyria
Elyria, Ohio 44035
Elyria, Ohio 44035
Armes Family Cancer Center
Findlay, Ohio 45840
Findlay, Ohio 45840
Blanchard Valley Hospital
Findlay, Ohio 45840
Findlay, Ohio 45840
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio 45005-1066
Franklin, Ohio 45005-1066
Dayton Physicians LLC-Atrium
Franklin, Ohio 45005
Franklin, Ohio 45005
Dayton Physicians LLC-Wayne
Greenville, Ohio 45331
Greenville, Ohio 45331
Greater Dayton Cancer Center
Kettering, Ohio 45409
Kettering, Ohio 45409
First Dayton Cancer Care
Kettering, Ohio 45420
Kettering, Ohio 45420
Kettering Medical Center
Kettering, Ohio 45429
Kettering, Ohio 45429
Fairfield Medical Center
Lancaster, Ohio 43130
Lancaster, Ohio 43130
OhioHealth Mansfield Hospital
Mansfield, Ohio 44903
Mansfield, Ohio 44903
Marietta Memorial Hospital
Marietta, Ohio 45750
Marietta, Ohio 45750
OhioHealth Marion General Hospital
Marion, Ohio 43302
Marion, Ohio 43302
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
Mayfield Heights, Ohio 44124
Lake University Ireland Cancer Center
Mentor, Ohio 44060
Mentor, Ohio 44060
Southwest General Health Center Ireland Cancer Center
Middleburg Heights, Ohio 44130
Middleburg Heights, Ohio 44130
Licking Memorial Hospital
Newark, Ohio 43055
Newark, Ohio 43055
Newark Radiation Oncology
Newark, Ohio 43055
Newark, Ohio 43055
Southern Ohio Medical Center
Portsmouth, Ohio 45662
Portsmouth, Ohio 45662
Ireland Cancer Center at Firelands Regional Medical Center
Sandusky, Ohio 44870
Sandusky, Ohio 44870
Springfield Regional Cancer Center
Springfield, Ohio 45504
Springfield, Ohio 45504
Springfield Regional Medical Center
Springfield, Ohio 45505
Springfield, Ohio 45505
ProMedica Flower Hospital
Sylvania, Ohio 43560
Sylvania, Ohio 43560
Contact:
Site Public Contact
419-824-1842
Site Public Contact
419-824-1842
The Toledo Hospital/Toledo Children's Hospital
Toledo, Ohio 43606
Toledo, Ohio 43606
Contact:
Site Public Contact
419-824-1842
Site Public Contact
419-824-1842
Dayton Physicians LLC-Upper Valley
Troy, Ohio 45373
Troy, Ohio 45373
Upper Valley Medical Center
Troy, Ohio 45373
Troy, Ohio 45373
University Hospitals Sharon Health Center
Wadsworth, Ohio 44281
Wadsworth, Ohio 44281
Saint Ann's Hospital
Westerville, Ohio 43081
Westerville, Ohio 43081
UH Seidman Cancer Center at Saint John Medical Center
Westlake, Ohio 44145
Westlake, Ohio 44145
UHHS-Westlake Medical Center
Westlake, Ohio 44145
Westlake, Ohio 44145
Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701
Zanesville, Ohio 43701
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
Oklahoma City, Oklahoma 73120
Contact:
Site Public Contact
405-752-3402
Site Public Contact
405-752-3402
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
Tulsa, Oklahoma 74146
Contact:
Site Public Contact
918-505-3200
Site Public Contact
918-505-3200
Saint Charles Health System
Bend, Oregon 97701
Bend, Oregon 97701
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Providence Oncology and Hematology Care Southeast
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Bay Area Hospital
Coos Bay, Oregon 97420
Coos Bay, Oregon 97420
Legacy Mount Hood Medical Center
Gresham, Oregon 97030
Gresham, Oregon 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Providence Newberg Medical Center
Newberg, Oregon 97132
Newberg, Oregon 97132
Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
Portland, Oregon 97210
Providence Portland Medical Center
Portland, Oregon 97213
Portland, Oregon 97213
Providence Saint Vincent Medical Center
Portland, Oregon 97225
Portland, Oregon 97225
Legacy Meridian Park Hospital
Tualatin, Oregon 97062
Tualatin, Oregon 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania 18015
Bethlehem, Pennsylvania 18015
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010
Bryn Mawr, Pennsylvania 19010
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
Chadds Ford, Pennsylvania 19317
Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
Jefferson Hills, Pennsylvania 15025
Lancaster General Hospital
Lancaster, Pennsylvania 17604
Lancaster, Pennsylvania 17604
Contact:
Site Public Contact
717-544-5511
Site Public Contact
717-544-5511
Riddle Memorial Hospital
Media, Pennsylvania 19063
Media, Pennsylvania 19063
Forbes Hospital
Monroeville, Pennsylvania 15146
Monroeville, Pennsylvania 15146
Paoli Memorial Hospital
Paoli, Pennsylvania 19301
Paoli, Pennsylvania 19301
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
Contact:
Site Public Contact
215-955-6084
Site Public Contact
215-955-6084
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
Pittsburgh, Pennsylvania 15212
Contact:
Site Public Contact
877-284-2000
Site Public Contact
877-284-2000
West Penn Hospital
Pittsburgh, Pennsylvania 15224
Pittsburgh, Pennsylvania 15224
Contact:
Site Public Contact
412-578-5000
Site Public Contact
412-578-5000
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
Reading Hospital
West Reading, Pennsylvania 19611
West Reading, Pennsylvania 19611
Contact:
Site Public Contact
610-988-9323
Site Public Contact
610-988-9323
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
Wexford, Pennsylvania 15090
Abington Memorial Hospital-Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
Willow Grove, Pennsylvania 19090
Lankenau Medical Center
Wynnewood, Pennsylvania 19096
Wynnewood, Pennsylvania 19096
Women and Infants Hospital
Providence, Rhode Island 02905
Providence, Rhode Island 02905
Contact:
Site Public Contact
401-274-1122
Site Public Contact
401-274-1122
AnMed Health Cancer Center
Anderson, South Carolina 29621
Anderson, South Carolina 29621
Saint Francis Hospital
Greenville, South Carolina 29601
Greenville, South Carolina 29601
Saint Francis Cancer Center
Greenville, South Carolina 29607
Greenville, South Carolina 29607
Rapid City Regional Hospital
Rapid City, South Dakota 57701
Rapid City, South Dakota 57701
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Sioux Falls, South Dakota 57104
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Avera Cancer Institute
Sioux Falls, South Dakota 57105
Sioux Falls, South Dakota 57105
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Sioux Falls, South Dakota 57117-5134
Wellmont Bristol Regional Medical Center
Bristol, Tennessee 37620
Bristol, Tennessee 37620
Memorial Hospital
Chattanooga, Tennessee 37404
Chattanooga, Tennessee 37404
Vanderbilt-Ingram Cancer Center Cool Springs
Franklin, Tennessee 37067
Franklin, Tennessee 37067
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Pulmonary Medicine Center of Chattanooga-Hixson
Hixson, Tennessee 37343
Hixson, Tennessee 37343
Wellmont Medical Associates Oncology and Hematology-Johnson City
Johnson City, Tennessee 37604
Johnson City, Tennessee 37604
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee 37660
Kingsport, Tennessee 37660
Wellmont Medical Associates Oncology and Hematology-Kingsport
Kingsport, Tennessee 37660
Kingsport, Tennessee 37660
Thompson Cancer Survival Center
Knoxville, Tennessee 37916
Knoxville, Tennessee 37916
Contact:
Site Public Contact
865-331-1812
Site Public Contact
865-331-1812
Thompson Cancer Survival Center - West
Knoxville, Tennessee 37932
Knoxville, Tennessee 37932
Contact:
Site Public Contact
865-331-1812
Site Public Contact
865-331-1812
Vanderbilt Breast Center at One Hundred Oaks
Nashville, Tennessee 37204
Nashville, Tennessee 37204
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
Nashville, Tennessee 37232
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Memorial GYN Plus
Ooltewah, Tennessee 37363
Ooltewah, Tennessee 37363
Saint Joseph Regional Cancer Center
Bryan, Texas 77802
Bryan, Texas 77802
Parkland Memorial Hospital
Dallas, Texas 75235
Dallas, Texas 75235
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
Dallas, Texas 75390
UT Southwestern/Simmons Cancer Center-Fort Worth
Fort Worth, Texas 76104
Fort Worth, Texas 76104
Inova Fairfax Hospital-Woodburn Infusion Clinic
Annandale, Virginia 22003
Annandale, Virginia 22003
Wellmont Medical Associates-Bristol
Bristol, Virginia 24201
Bristol, Virginia 24201
Kaiser Permanente-Burke Medical Center
Burke, Virginia 22015
Burke, Virginia 22015
University of Virginia Cancer Center
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
Inova Fairfax Hospital
Falls Church, Virginia 22042
Falls Church, Virginia 22042
Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia 22102
McLean, Virginia 22102
Contact:
Site Public Contact
240-632-4284
Site Public Contact
240-632-4284
Southwest VA Regional Cancer Center
Norton, Virginia 24273
Norton, Virginia 24273
Virginia Gynecologic Oncology
Richmond, Virginia 23229
Richmond, Virginia 23229
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
Richmond, Virginia 23298
Carilion Clinic Gynecological Oncology
Roanoke, Virginia 24016
Roanoke, Virginia 24016
Contact:
Site Public Contact
540-985-8510
Site Public Contact
540-985-8510
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
Aberdeen, Washington 98520
MultiCare Auburn Medical Center
Auburn, Washington 98001
Auburn, Washington 98001
Virginia Mason Bainbridge Island Medical Center
Bainbridge Island, Washington 98110
Bainbridge Island, Washington 98110
Overlake Hospital Medical Center
Bellevue, Washington 98004
Bellevue, Washington 98004
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
Bellingham, Washington 98225
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington 98310
Bremerton, Washington 98310
Harrison Medical Center
Bremerton, Washington 98310
Bremerton, Washington 98310
Highline Medical Center-Main Campus
Burien, Washington 98166
Burien, Washington 98166
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
Centralia, Washington 98531
Swedish Medical Center-Edmonds
Edmonds, Washington 98026
Edmonds, Washington 98026
Saint Elizabeth Hospital
Enumclaw, Washington 98022
Enumclaw, Washington 98022
Providence Regional Cancer Partnership
Everett, Washington 98201
Everett, Washington 98201
Virginia Mason Federal Way Medical Center
Federal Way, Washington 98002
Federal Way, Washington 98002
Saint Francis Hospital
Federal Way, Washington 98003
Federal Way, Washington 98003
Tacoma/Valley Radiation Oncology Centers-Gig Harbor
Gig Harbor, Washington 98332
Gig Harbor, Washington 98332
MultiCare Gig Harbor Medical Park
Gig Harbor, Washington 98335
Gig Harbor, Washington 98335
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
Issaquah, Washington 98029
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
Kennewick, Washington 99336
Northwest Cancer Clinic
Kennewick, Washington 99336
Kennewick, Washington 99336
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
Lacey, Washington 98503
Saint Clare Hospital
Lakewood, Washington 98499
Lakewood, Washington 98499
PeaceHealth Saint John Medical Center
Longview, Washington 98632
Longview, Washington 98632
Virginia Mason Lynnwood Medical Center
Lynnwood, Washington 98036
Lynnwood, Washington 98036
Jefferson Healthcare
Port Townsend, Washington 98368
Port Townsend, Washington 98368
Contact:
Site Public Contact
360-344-3091
Site Public Contact
360-344-3091
Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington 98370
Poulsbo, Washington 98370
Peninsula Cancer Center
Poulsbo, Washington 98370
Poulsbo, Washington 98370
MultiCare Good Samaritan Hospital
Puyallup, Washington 98372
Puyallup, Washington 98372
Tacoma/Valley Radiation Oncology Centers-Puyallup
Puyallup, Washington 98372
Puyallup, Washington 98372
Valley Medical Center
Renton, Washington 98055
Renton, Washington 98055
Virginia Mason Medical Center
Seattle, Washington 98101
Seattle, Washington 98101
Pacific Gynecology Specialists
Seattle, Washington 98104
Seattle, Washington 98104
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
Seattle, Washington 98107
Kaiser Permanente Washington
Seattle, Washington 98112
Seattle, Washington 98112
Swedish Medical Center-First Hill
Seattle, Washington 98122-4307
Seattle, Washington 98122-4307
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
Seattle, Washington 98122-5711
Providence Regional Cancer System-Shelton
Shelton, Washington 98584
Shelton, Washington 98584
Rockwood Clinic Cancer Treatment Center-Valley
Spokane Valley, Washington 99216
Spokane Valley, Washington 99216
Rockwood Cancer Treatment Center-DHEC-Downtown
Spokane, Washington 99204
Spokane, Washington 99204
Rockwood North Cancer Treatment Center
Spokane, Washington 99218
Spokane, Washington 99218
Tacoma/Valley Radiation Oncology Centers-Jackson Hall
Tacoma, Washington 97405
Tacoma, Washington 97405
Franciscan Research Center-Northwest Medical Plaza
Tacoma, Washington 98405
Tacoma, Washington 98405
MultiCare Tacoma General Hospital
Tacoma, Washington 98405
Tacoma, Washington 98405
Northwest Medical Specialties PLLC
Tacoma, Washington 98405
Tacoma, Washington 98405
Tacoma/Valley Radiation Oncology Centers-Saint Joe's
Tacoma, Washington 98405
Tacoma, Washington 98405
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
Vancouver, Washington 98664
Legacy Salmon Creek Hospital
Vancouver, Washington 98686
Vancouver, Washington 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
Walla Walla, Washington 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington 98902
Yakima, Washington 98902
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
Yelm, Washington 98597
United Hospital Center
Bridgeport, West Virginia 26330
Bridgeport, West Virginia 26330
West Virginia University Charleston Division
Charleston, West Virginia 25304
Charleston, West Virginia 25304
Contact:
Site Public Contact
304-388-9944
Site Public Contact
304-388-9944
WVUH-Berkely Medical Center
Martinsburg, West Virginia 25401
Martinsburg, West Virginia 25401
Monongalia Hospital
Morgantown, West Virginia 26505
Morgantown, West Virginia 26505
Contact:
Site Public Contact
304-598-6560
Site Public Contact
304-598-6560
West Virginia University Healthcare
Morgantown, West Virginia 26506
Morgantown, West Virginia 26506
Camden Clark Medical Center
Parkersburg, West Virginia 26101
Parkersburg, West Virginia 26101
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
Burlington, Wisconsin 53105
Aurora Health Center-Fond du Lac
Fond Du Lac, Wisconsin 54937
Fond Du Lac, Wisconsin 54937
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
Germantown, Wisconsin 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Grafton, Wisconsin 53024
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Green Bay, Wisconsin 54311
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Kenosha, Wisconsin 53142
University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
Madison, Wisconsin 53792
Contact:
Site Public Contact
800-622-8922
Site Public Contact
800-622-8922
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
Marinette, Wisconsin 54143
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
Milwaukee, Wisconsin 53209
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Milwaukee, Wisconsin 53215
Froedtert and the Medical College of Wisconsin
Milwaukee, Wisconsin 53226
Milwaukee, Wisconsin 53226
Contact:
Site Public Contact
414-805-4380
Site Public Contact
414-805-4380
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Milwaukee, Wisconsin 53233
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
New Richmond, Wisconsin 54017
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
Racine, Wisconsin 53406
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Aurora Medical Center in Summit
Summit, Wisconsin 53066
Summit, Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Two Rivers, Wisconsin 54241
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
Wauwatosa, Wisconsin 53226
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
West Allis, Wisconsin 53227
Cheyenne Regional Medical Center-West
Cheyenne, Wyoming 82001
Cheyenne, Wyoming 82001
Billings Clinic-Cody
Cody, Wyoming 82414
Cody, Wyoming 82414
Welch Cancer Center
Sheridan, Wyoming 82801
Sheridan, Wyoming 82801
Advance Oncology Center
Aguadilla, Puerto Rico 00603
Aguadilla, Puerto Rico 00603
Contact:
Site Public Contact
787-997-2222
Site Public Contact
787-997-2222
Doctor's Cancer Center-Arecibo
Arecibo, Puerto Rico 00614
Arecibo, Puerto Rico 00614
Cancer Center-Metro Medical Center Bayamon
Bayamon, Puerto Rico 00959-5060
Bayamon, Puerto Rico 00959-5060
Contact:
Site Public Contact
787-395-7085
Site Public Contact
787-395-7085
Hematologia Oncologia San Pablo
Bayamon, Puerto Rico 00961
Bayamon, Puerto Rico 00961
Contact:
Site Public Contact
787-269-4670
Site Public Contact
787-269-4670
HIMA San Pablo Oncologic Hospital
Caguas, Puerto Rico 00726
Caguas, Puerto Rico 00726
Contact:
Site Public Contact
787-653-3434
Site Public Contact
787-653-3434
Doctors Cancer Center
Manati, Puerto Rico 00674
Manati, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397
Site Public Contact
787-621-4397
Instituto Oncologia Moderna Ponce
Ponce, Puerto Rico 00716
Ponce, Puerto Rico 00716
Contact:
Site Public Contact
787-848-0606
Site Public Contact
787-848-0606
San Juan Community Oncology Group
San Juan, Puerto Rico 00917
San Juan, Puerto Rico 00917
Contact:
Site Public Contact
787-274-3387
Site Public Contact
787-274-3387
Primary Care Physician Group
San Juan, Puerto Rico 00920
San Juan, Puerto Rico 00920
Contact:
Site Public Contact
787-792-9833
Site Public Contact
787-792-9833
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
San Juan City Hospital
San Juan, Puerto Rico 00936
San Juan, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296
Site Public Contact
787-763-1296
Centro de Hematologia y Oncologia del Sur
Santa Isabel, Puerto Rico 00757
Santa Isabel, Puerto Rico 00757
Contact:
Site Public Contact
787-845-0805
Site Public Contact
787-845-0805
More Details
- NCT ID
- NCT02839707
- Status
- Recruiting
- Sponsor
- National Cancer Institute (NCI)
Detailed Description
PRIMARY OBJECTIVES:
I. Estimate the probability of a dose limiting toxicity (DLT) following cycle 1 of experimental regimens (pegylated liposomal doxorubicin hydrochloride [pegylated liposomal doxorubicin] [PLD] and atezolizumab and PLD/bevacizumab and atezolizumab). (Safety lead-in) II. Estimate and compare the hazard of first progression or death (progression free survival [PFS]) of each experimental regimen relative to the reference regimen, PLD and bevacizumab. (Phase II study) III. Estimate and compare the hazard of death and the hazard of first progression or death (PFS) of each experimental regimen relative to the reference regimen. (Phase III)
SECONDARY OBJECTIVES:
I. Estimate and compare the probabilities of response rate (objective response rate [ORR], either partial or complete response) defined by Response Evaluation Criteria in Solid Tumors (RECIST) version (v)1.1 criteria on each study regimen. (Phase II study) II. Estimate the frequency and severity of adverse events as classified and graded with Common Terminology Criteria for Adverse Events (CTCAE) in those patients who initiate their randomly assigned study treatment. (Phase II study) III. Estimate and compare ORR in each treatment group. (Phase III study) IV. Estimate the frequency and severity of adverse events in those patients who initiate their randomly assigned study treatment. (Phase III study) V. Estimate and compare mean patient reported outcome scores (PROs) as measured by National Comprehensive Cancer Network (NCCN)-Functional Assessment of Cancer Therapy (FACT) ovarian symptom index (NFOSI)-18 disease-related symptoms (DRS). (Phase III study) VI. Estimate and compare the treatment groups on the basis of the PROs: treatment side effects (TSE), function/well-being (FWB), fatigue (Functional Assessment of Chronic Illness Therapy [FACIT]-fatigue [F] subscale) and abdominal discomfort (FACT/Gynecologic Oncology Group [GOG]-abdominal discomfort [AD] subscale). (Phase III study)
TRANSLATIONAL SCIENCE OBJECTIVES:
I. To determine whether biomarker levels in pre-treatment tissue, and pre- or on-treatment peripheral blood, and stool specimens are associated with ORR, PFS and/or overall survival (OS).
II. To determine whether changes in quantitative biomarker parameters after the first 6 and 12 weeks of therapy predict ORR, PFS and/or OS.
OUTLINE: Patients will be randomized to 1 of 3 arms.
ARM I: Patients receive pegylated liposomal doxorubicin hydrochloride intravenously (IV) over 60 minutes on day 1 and atezolizumab IV over 30-60 minutes on days 1 and 15.
ARM II: Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1, bevacizumab IV over 30-90 minutes on days 1 and 15, and atezolizumab IV over 30-60 minutes on days 1 and 15.
ARM III: Patients receive pegylated liposomal doxorubicin hydrochloride IV over 60 minutes on day 1 and bevacizumab IV over 30-90 minutes on days 1 and 15.
In all arms, courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.
After completion of study treatment, patients are followed up every 3 months for up to 2 years, then every 6 months for up to 3 years.