Purpose

This randomized phase III trial studies how well pembrolizumab works in treating patients with triple-negative breast cancer. Monoclonal antibodies, such as pembrolizumab, may interfere with the ability of tumor cells to grow and spread.

Conditions

Eligibility

Eligible Ages
Over 18 Years
Eligible Genders
All
Accepts Healthy Volunteers
No

Criteria


Inclusion Criteria:

- STEP 1 REGISTRATION

- Patients must have histologically confirmed estrogen receptor (ER)-, progesterone
receptor (PR)- and HER2-negative (triple-negative, TNBC) or ER, PR, and HER2 equivocal
status and must not have received and not be planning to receive adjuvant anti-HER2 or
endocrine therapies after completion of neoadjuvant chemotherapy; patients who are
HER2 positive by American Society of Clinical Oncology (ASCO) College of American
Pathologists (CAP) guidelines are ineligible; HER2 negative and HER2 equivocal cases
as per ASCO CAP guidelines that do not receive HER2-targeted therapy are eligible;
patients with weekly ER or PR positive disease, defined as ER and/or PR < 5% by
immunohistochemistry, are eligible if the treating physician considers the patient not
eligible for adjuvant endocrine therapy; residual disease must be >= 1 cm in greatest
dimension, and/or have positive lymph nodes (ypN+) observed on pathologic exam

- NOTE: Immunohistochemistry (IHC)-positive isolated tumor cells in the lymph node
(N0 [i+]) are not considered node-positive and these patients also must have >= 1
cm residual invasive cancer in the breast in order to be eligible

- Patients must not have metastatic disease (i.e., must be M0); patients must not have
locally recurrent disease

- It is preferred that axillary lymph node sampling is performed after completion of
neoadjuvant chemotherapy to allow more accurate assessment of pathologic response;
patients must have a complete axillary lymph node dissection after neoadjuvant
chemotherapy in the following situations (exceptions will be granted for patients
participating in the Alliance A11202 trial):

- Patients had documented pathologic involvement of the axillary nodes (fine needle
aspiration [FNA] or core biopsy) before neoadjuvant chemotherapy and had sentinel
node biopsy after neoadjuvant chemotherapy with positive sentinel node(s)

- Patient had documented pathologic involvement of the axillary nodes (FNA or core
biopsy) before neoadjuvant chemotherapy and had only 1 sentinel lymph node
removed after neoadjuvant chemotherapy

- NOTE: Patients who undergo sentinel node biopsy before starting neoadjuvant
treatment and do not undergo post neoadjuvant assessment of the axillary
nodes or who have negative axillary nodes on post neoadjuvant assessment
must have >= 1 cm residual invasive cancer in the breast after completion of
neoadjuvant chemotherapy

- Patients must have a minimum of five, available unstained slides from the residual
(post-neoadjuvant) invasive tumor in primary site or lymph node; (these will be
submitted to determine PD-L1 expression) the tumor tissue must be adequate for PD-L1
testing, which typically requires a minimum of 100 cancer cells per slide

- NOTE: Initial order for specimen kits should be placed at least two weeks prior
to registering the first patient at each site

- Patients must be offered the opportunity to participate in specimen banking

- Patients must have had neoadjuvant chemotherapy followed by surgery; the recommended
neoadjuvant treatment should include 16-24 weeks of a third generation chemotherapy
regimen as recommended by National Comprehensive Cancer Network (NCCN) guidelines for
triple negative breast cancer (examples include dose dense adriamycin-cytoxan [AC]
followed by dose-dense paclitaxel; weekly paclitaxel x 12 followed or preceded by
cyclophosphamide-adriamycin-fluorouracil [FAC], fluorouracil-epirubicin-cytoxan [FEC],
AC or dose dense AC; docetaxel either followed or preceded by FEC/FAC or AC;
carboplatin-containing neoadjuvant chemotherapy is also allowed); patients who cannot
complete all planned treatment cycles for any reason are considered high risk and
therefore are eligible for the study if they have residual disease; patients must have
resolution of adverse event(s) of the most recent prior chemotherapy to grade 1 or
less, except alopecia and =< grade 2 neuropathy which are allowed

- Patients may receive post-operative (adjuvant) chemotherapy for up to 24 weeks of
duration (e.g. 8 cycles of capecitabine as in the CREATE-X trial) after completion of
surgery at the discretion of the treating physician; patients must have resolution of
adverse event(s) of the most recent prior chemotherapy to grade 1 or less, except
alopecia and =< grade 2 neuropathy which are allowed; patients that have received
adjuvant chemotherapy must be registered to screening within 35 days after completing
treatment

- Patients must have completed their final breast surgery (rendering them free from
disease) with clear resection margins for invasive cancer and DCIS within the
following timelines:

- 90 days prior to screening registration for patients not receiving post-operative
(adjuvant) chemotherapy OR

- 270 days prior to screening registration for patients who have received
post-operative (adjuvant) chemotherapy Patients who receive postoperative
chemotherapy may receive radiation therapy before or after the chemotherapy; a
short course of reduced dose chemotherapy concomitant with radiation for
radiation sensitization is not considered to be adjuvant chemotherapy; positive
margins are allowed only if the surgical team of the patient deems further
resection impossible

- Patients for whom radiation therapy (RT) to the affected breast or chest wall and
regional nodal areas is clinically indicated as per NCCN treatment guidelines, should
receive RT after randomization when possible, and receive MK-3475 (pembrolizumab)
concurrent with RT, if randomized to the experimental arm; however, RT administered,
or initiated, prior to registration is also allowed; pembrolizumab may be added to
ongoing radiation, or started after its completion, if randomized to the experimental
arm, provided there are no > grade 2 radiation-related skin toxicities; patients who
have not yet started radiation must specify at the time of screening registration
whether or not they will receive RT and the extent of intended RT

- Patients must not have had prior immunotherapy with anti-PD-L1, anti-PD-1, anti-CTLA4
or similar drugs; patients must not be planning to receive any of the prohibited
therapies during the screening or treatment phases of the study

- Patients must not be planning to receive concomitantly other biologic therapy,
hormonal therapy, other chemotherapy, surgery or other anti-cancer therapy except
radiation therapy while receiving treatment on this protocol; however, patients
receiving extended adjuvant endocrine therapy for an earlier ER positive breast cancer
treated with curative intent and without recurrence for at least 5 years may continue
with their endocrine therapy

- Patients must have Zubrod performance status =< 2

- Patients must not have a history of (non-infectious) pneumonitis that required
steroids or evidence of active pneumonitis

- Patients must not have an active infection requiring systemic therapy

- Patients must not have active autoimmune disease that has required systemic treatment
in past 2 years (i.e., with use of disease modifying agents, corticosteroids or
immunosuppressive drugs); replacement therapy (e.g., thyroxine, insulin, or
physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency,
etc.) is not considered a form of systemic treatment

- Patients must not have received live vaccines within 30 days prior to registration;
examples of live vaccines include, but are not limited to, the following: measles,
mumps, rubella, chicken pox, shingles, yellow fever, rabies, Bacillus Calmette-Guerin
(BCG), and typhoid (oral) vaccine; seasonal influenza vaccines for injection are
generally killed virus vaccines and are allowed; however, intranasal influenza
vaccines (e.g., Flu-Mist) are live attenuated vaccines, and are not allowed

- Patients must not have known active hepatitis B virus (HBV) or hepatitis C virus (HCV)
infection prior to registration; patients who have completed curative therapy for HCV
are eligible; patients with known human immunodeficiency virus (HIV) infection are
eligible if they meet each of the following 3 criteria:

- CD4 counts >= 350 mm^3

- Serum HIV viral load of < 25,000 IU/ml and

- Treated on a stable antiretroviral regimen

- No other prior invasive malignancy is allowed except for the following: adequately
treated basal (or squamous cell) skin cancer, in situ breast or cervical cancer; stage
I or II invasive cancer treated with a curative intent without evidence of disease
recurrence for at least five years

- Patients must have complete history and physical examination within 28 days prior to
registration

- Patients must be informed of the investigational nature of this study and must sign
and give written informed consent for this protocol in accordance with institutional
and federal guidelines

- As a part of the Oncology Patient Enrollment Network (OPEN) registration process the
treating institution's identity is provided in order to ensure that the current
(within 365 days) date of institutional review board approval for this study has been
entered in the system

- STEP 2 REGISTRATION

- Patients must not be registered to step 2 until receiving confirmation from the
Southwest Oncology Group (SWOG) Statistical Center that the patient's tissue specimen
was adequate for PD-L1 testing; patients must be registered within 7 days of receiving
the e-mail notification confirming submission was evaluable for PD-L1 status

- Absolute neutrophil count (ANC) >= 1,500 microliter (mcL), obtained within 28 days
prior to step 2 registration

- Platelets >= 100,000/mcL, obtained within 28 days prior to step 2 registration

- Hemoglobin >= 9 g/dL, obtained within 28 days prior to step 2 registration

- A serum thyroid-stimulating hormone (TSH) must be obtained within 28 days prior to
step 2 registration to obtain a baseline value

- Total bilirubin =< 1.5 x institutional upper limit of normal (IULN) (except Gilbert's
syndrome, who must have a total bilirubin < 3.0 mg/dL), obtained within 28 days prior
to step 2 registration

- Serum glutamic-oxaloacetic transaminase (SGOT) (aspartate aminotransferase [AST]) or
serum glutamate pyruvate transaminase (SGPT) (alanine aminotransferase [ALT]) =< 2.5 x
IULN, obtained within 28 days prior to step 2 registration

- Alkaline phosphatase =< 2.5 x IULN, obtained within 28 days prior to step 2
registration

- Serum creatinine =< IULN OR measured or calculated creatinine clearance >= 60 mL/min,
obtained within 28 days prior to step 2 registration

- Women of childbearing potential must have a negative urine or serum pregnancy test
within 28 day prior to registration; women/men of reproductive potential must have
agreed to use an effective contraceptive method for the course of the study through
120 days after the last dose of study medication; should a woman become pregnant or
suspect she is pregnant while she or her partner is participating in this study, she
should inform her treating physician immediately; a woman is considered to be of
"reproductive potential" if she has had menses at any time in the preceding 12
consecutive months; in addition to routine contraceptive methods, "effective
contraception" also includes heterosexual celibacy and surgery intended to prevent
pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy,
bilateral oophorectomy, bilateral tubal ligation, or vasectomy; however, if at any
point a previously celibate patient chooses to become heterosexually active during the
time period for use of contraceptive measures outlined in the protocol, he/she is
responsible for beginning contraceptive measures; patients must not be pregnant or
nursing

- Site must verify that there is no known change in the step 1 eligibility since initial
registration

Study Design

Phase
Phase 3
Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel Assignment
Primary Purpose
Treatment
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Arm I (observation)
Patients receive no treatment but are monitored at standard clinical intervals during first year after randomization. Patients are examined every 12 weeks for 1 year, every 6 months for 4 years, and then annually for 5 years. Patients may undergo radiation therapy within 12 weeks of last breast cancer operation or after treatment.
  • Other: Laboratory Biomarker Analysis
    Correlative studies
  • Other: Patient Observation
    Undergo standard monitoring
    Other names:
    • Active Surveillance
    • deferred therapy
    • expectant management
    • observation
    • Watchful Waiting
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other names:
    • Cancer Radiotherapy
    • Irradiate
    • Irradiated
    • irradiation
    • Radiation
    • Radiotherapeutics
    • RADIOTHERAPY
    • RT
    • Therapy, Radiation
Experimental
Arm II (pembrolizumab)
Patients receive pembrolizumab IV over 30 minutes on days 1 and 22. Courses repeat every 42 days for 52 weeks in the absence of disease progression or unacceptable toxicity. Patients may undergo radiation therapy within 12 weeks of last breast cancer operation or after treatment.
  • Other: Laboratory Biomarker Analysis
    Correlative studies
  • Biological: Pembrolizumab
    Given IV
    Other names:
    • Keytruda
    • Lambrolizumab
    • MK-3475
    • SCH 900475
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Radiation: Radiation Therapy
    Undergo radiation therapy
    Other names:
    • Cancer Radiotherapy
    • Irradiate
    • Irradiated
    • irradiation
    • Radiation
    • Radiotherapeutics
    • RADIOTHERAPY
    • RT
    • Therapy, Radiation

Recruiting Locations

University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
Contact:
Site Public Contact
205-934-0220
tmyrick@uab.edu

Katmai Oncology Group
Anchorage, Alaska 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

University of Arizona Cancer Center-North Campus
Tucson, Arizona 85719
Contact:
Site Public Contact
800-327-2873

The University of Arizona Medical Center-University Campus
Tucson, Arizona 85724
Contact:
Site Public Contact
520-626-9008

Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas 72401
Contact:
Site Public Contact
870-936-7067
Dawn.Smith@BMHCC.org

University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Contact:
Site Public Contact
501-686-8274

Kaiser Permanente-Anaheim
Anaheim, California 92806
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

PCR Oncology
Arroyo Grande, California 93420
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Sutter Auburn Faith Hospital
Auburn, California 95602
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

AIS Cancer Center at San Joaquin Community Hospital
Bakersfield, California 93301
Contact:
Site Public Contact
661-323-4673

Kaiser Permanente-Baldwin Park
Baldwin Park, California 91706
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Bellflower
Bellflower, California 90706
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

City of Hope Corona
Corona, California 92879
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

City of Hope Comprehensive Cancer Center
Duarte, California 91010
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Epic Care-Dublin
Dublin, California 94568
Contact:
Site Public Contact
925-875-1677

Epic Care Partners in Cancer Care
Emeryville, California 94608
Contact:
Site Public Contact
510-629-6682

Kaiser Permanente-Fontana
Fontana, California 92335
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Saint Jude Medical Center
Fullerton, California 92835
Contact:
Site Public Contact
714-446-5642

Marin Cancer Care Inc
Greenbrae, California 94904
Contact:
Site Public Contact
415-925-5000
info@marinspecialtycare.com

Kaiser Permanente - Harbor City
Harbor City, California 90710
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Irvine
Irvine, California 92618
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Loma Linda University Medical Center
Loma Linda, California 92354
Contact:
Site Public Contact
909-558-3375

Kaiser Permanente Los Angeles Medical Center
Los Angeles, California 90027
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

USC / Norris Comprehensive Cancer Center
Los Angeles, California 90033
Contact:
Site Public Contact
323-865-0451

Kaiser Permanente-Cadillac
Los Angeles, California 90034
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Contra Costa Regional Medical Center
Martinez, California 94553-3156
Contact:
Site Public Contact
925-957-5400

Fremont - Rideout Cancer Center
Marysville, California 95901
Contact:
Site Public Contact
530-749-4400

City of Hope Mission Hills
Mission Hills, California 91345
Contact:
Site Public Contact
800-826-4673
becomingapatient@coh.org

Memorial Medical Center
Modesto, California 95355
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Community Hospital of Monterey Peninsula
Monterey, California 93940
Contact:
Site Public Contact
831-625-4753

Palo Alto Medical Foundation-Camino Division
Mountain View, California 94040
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Kaiser Permanente-Oakland
Oakland, California 94611
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Ontario
Ontario, California 91761
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Saint Joseph Hospital - Orange
Orange, California 92868
Contact:
Site Public Contact
714-734-6220

UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange, California 92868
Contact:
Site Public Contact
877-827-8839
ucstudy@uci.edu

Desert Regional Medical Center
Palm Springs, California 92262
Contact:
Site Public Contact
760-416-4730

Palo Alto Medical Foundation Health Care
Palo Alto, California 94301
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Stanford Cancer Institute Palo Alto
Palo Alto, California 94304
Contact:
Site Public Contact
650-498-7061
ccto-office@stanford.edu

Kaiser Permanente - Panorama City
Panorama City, California 91402
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Riverside
Riverside, California 92505
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente-Roseville
Roseville, California 95661
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Sutter Roseville Medical Center
Roseville, California 95661
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Kaiser Permanente Downtown Commons
Sacramento, California 95814
Contact:
Site Public Contact
877-642-4691
kpoct@kp.org

Sutter Medical Center Sacramento
Sacramento, California 95816
Contact:
Site Public Contact
916-454-6500
cancerinfo@sutterhealth.org

University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
Contact:
Site Public Contact
916-734-3089

Kaiser Permanente - Sacramento
Sacramento, California 95825
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-San Diego Zion
San Diego, California 92120
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

California Pacific Medical Center-Pacific Campus
San Francisco, California 94115
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Kaiser Permanente-San Francisco
San Francisco, California 94115
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Teresa-San Jose
San Jose, California 95119
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente San Leandro
San Leandro, California 94577
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Kaiser Permanente-San Marcos
San Marcos, California 92078
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Palo Alto Medical Foundation-Santa Cruz
Santa Cruz, California 95065
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Kaiser Permanente-South San Francisco
South San Francisco, California 94080
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Palo Alto Medical Foundation-Sunnyvale
Sunnyvale, California 94086
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee, California 96161
Contact:
Site Public Contact
530-582-6450

Kaiser Permanente-Vallejo
Vallejo, California 94589
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589
Contact:
Site Public Contact
415-209-2686
bernicl@sutterhealth.org

Kaiser Permanente-Walnut Creek
Walnut Creek, California 94596
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Presbyterian Intercommunity Hospital
Whittier, California 90602
Contact:
Site Public Contact
562-698-0811

Kaiser Permanente-Woodland Hills
Woodland Hills, California 91367
Contact:
Site Public Contact
800-398-3996
clinical.trials@kp.org

Rocky Mountain Cancer Centers-Aurora
Aurora, Colorado 80012
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

University of Colorado Hospital
Aurora, Colorado 80045
Contact:
Site Public Contact
720-848-0650

Rocky Mountain Cancer Centers-Boulder
Boulder, Colorado 80304
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
Contact:
Site Public Contact
719-365-2406

Memorial Hospital North
Colorado Springs, Colorado 80920
Contact:
Site Public Contact
719-364-6700

Kaiser Permanente-Franklin
Denver, Colorado 80205
Contact:
Site Public Contact
303-764-5056
josh.b.gordon@nsmtp.kp.org

National Jewish Health-Main Campus
Denver, Colorado 80206
Contact:
Site Public Contact
877-225-5654
glicht@co-cancerresearch.org

Comprehensive Cancer Care and Research Institute of Colorado LLC
Englewood, Colorado 80113
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Poudre Valley Hospital
Fort Collins, Colorado 80524
Contact:
Site Public Contact
970-297-6150

National Jewish Health-Western Hematology Oncology
Golden, Colorado 80401
Contact:
Site Public Contact
303-777-2663
glicht@co-cancerresearch.org

North Colorado Medical Center
Greeley, Colorado 80631
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
Contact:
Site Public Contact
303-764-5056
josh.b.gordon@nsmtp.kp.org

Rocky Mountain Cancer Centers-Littleton
Littleton, Colorado 80120
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124
Contact:
Site Public Contact
303-764-5056
josh.b.gordon@nsmtp.kp.org

Rocky Mountain Cancer Centers-Sky Ridge
Lone Tree, Colorado 80124
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Longmont United Hospital
Longmont, Colorado 80501
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

McKee Medical Center
Loveland, Colorado 80539
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Parker Adventist Hospital
Parker, Colorado 80138
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

National Jewish Health-Northern Hematology Oncology
Thornton, Colorado 80260
Contact:
Site Public Contact
303-777-2663
glicht@co-cancerresearch.org

SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
Contact:
Site Public Contact
303-777-2663
ccrp@co-cancerresearch.org

Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Greenwich Hospital
Greenwich, Connecticut 06830
Contact:
Site Public Contact
203-863-3698

Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Yale University
New Haven, Connecticut 06520
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut 06477
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital-Torrington Care Center
Torrington, Connecticut 06790
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital Care Center-Trumbull
Trumbull, Connecticut 06611
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Helen F Graham Cancer Center
Newark, Delaware 19713
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Contact:
Site Public Contact
302-623-4450
KDempsey@christianacare.org

Halifax Health Medical Center-Centers for Oncology
Daytona Beach, Florida 32114
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

University of Florida Health Science Center - Gainesville
Gainesville, Florida 32610
Contact:
Site Public Contact
352-273-8010
cancer-center@ufl.edu

Baptist MD Anderson Cancer Center
Jacksonville, Florida 32207
Contact:
Site Public Contact
904-202-7051

Mount Sinai Medical Center
Miami Beach, Florida 33140
Contact:
Site Public Contact
305-674-2625
yenrique@msmc.com

UF Cancer Center at Orlando Health
Orlando, Florida 32806
Contact:
Site Public Contact
321-841-7246
CancerClinicalTrials@orlandohealth.com

Sacred Heart Hospital
Pensacola, Florida 32504
Contact:
Site Public Contact
850-416-4611
eebrou@ascension.org

Cleveland Clinic-Weston
Weston, Florida 33331
Contact:
Site Public Contact
954-659-5705
CancerAnswer@ccf.org

Phoebe Putney Memorial Hospital
Albany, Georgia 31701
Contact:
Site Public Contact
229-312-0405
ga_cares@augusta.edu

Northside Hospital
Atlanta, Georgia 30342
Contact:
Site Public Contact
404-303-3355
ClinicalTrials@northside.com

Dekalb Medical Center
Decatur, Georgia 30033
Contact:
Site Public Contact
404-501-2738
clinicaltrialsoncology@dekalbmedical.org

Gwinnett Medical Center
Lawrenceville, Georgia 30046
Contact:
Site Public Contact
678-312-2666

Memorial Health University Medical Center
Savannah, Georgia 31404
Contact:
Site Public Contact
912-350-7887
clayter1@memorialhealth.com

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
Contact:
Site Public Contact
protocols@swog.org

South Georgia Medical Center/Pearlman Cancer Center
Valdosta, Georgia 31602
Contact:
Site Public Contact
229-259-4628
maryann.heddon@sgmc.org

Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Luke's Mountain States Tumor Institute
Boise, Idaho 83712
Contact:
Site Public Contact
protocols@swog.org

Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Kootenai Medical Center
Coeur d'Alene, Idaho 83814
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Mountain States Tumor Institute - Fruitland
Fruitland, Idaho 83619
Contact:
Site Public Contact
protocols@swog.org

Saint Luke's Mountain States Tumor Institute - Meridian
Meridian, Idaho 83642
Contact:
Site Public Contact
protocols@swog.org

Saint Alphonsus Medical Center-Nampa
Nampa, Idaho 83686
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Luke's Mountain States Tumor Institute - Nampa
Nampa, Idaho 83686
Contact:
Site Public Contact
protocols@swog.org

Kootenai Cancer Center
Post Falls, Idaho 83854
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kootenai Cancer Clinic
Sandpoint, Idaho 83864
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Luke's Mountain States Tumor Institute-Twin Falls
Twin Falls, Idaho 83301
Contact:
Site Public Contact
protocols@swog.org

Northwest Community Hospital
Arlington Heights, Illinois 60005
Contact:
Site Public Contact
847-618-4968

Rush - Copley Medical Center
Aurora, Illinois 60504
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Canton
Canton, Illinois 61520
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Carthage
Carthage, Illinois 62321
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Mount Sinai Hospital Medical Center
Chicago, Illinois 60608
Contact:
Site Public Contact
773-257-5960
suhi@sinai.org

Northwestern University
Chicago, Illinois 60611
Contact:
Site Public Contact
312-695-1301
cancer@northwestern.edu

Rush University Medical Center
Chicago, Illinois 60612
Contact:
Site Public Contact
312-942-5498
clinical_trials@rush.edu

University of Illinois
Chicago, Illinois 60612
Contact:
Site Public Contact
312-355-3046

University of Chicago Comprehensive Cancer Center
Chicago, Illinois 60637
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Weiss Memorial Hospital
Chicago, Illinois 60640
Contact:
Site Public Contact
773-564-5032

Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Contact:
Site Public Contact
217-876-4740
kcheek@dmhhs.org

Crossroads Cancer Center
Effingham, Illinois 62401
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Illinois CancerCare-Eureka
Eureka, Illinois 61530
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Contact:
Site Public Contact
630-315-1918
Claudine.Gamster@CadenceHealth.org

Joliet Oncology-Hematology Associates Limited
Joliet, Illinois 60435
Contact:
Site Public Contact
815-730-3098
maureenc@jolietoncology.com

Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Macomb
Macomb, Illinois 61455
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Loyola University Medical Center
Maywood, Illinois 60153
Contact:
Site Public Contact
708-226-4357

Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
Contact:
Site Public Contact
618-242-4600

Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Pekin
Pekin, Illinois 61554
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peoria
Peoria, Illinois 61615
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Peru
Peru, Illinois 61354
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

Illinois CancerCare-Princeton
Princeton, Illinois 61356
Contact:
Site Public Contact
309-243-3605
andersonj@illinoiscancercare.com

West Suburban Medical Center
River Forest, Illinois 60305
Contact:
Site Public Contact
708-763-2707

Southern Illinois University School of Medicine
Springfield, Illinois 62702
Contact:
Site Public Contact
217-545-7929

Springfield Clinic
Springfield, Illinois 62702
Contact:
Site Public Contact
800-444-7541

Cancer Care Specialists of Illinois-Swansea
Swansea, Illinois 62226
Contact:
Site Public Contact
217-876-4740
rhamrick@dmhhs.org

Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Contact:
Site Public Contact
630-315-1918
Claudine.Gamster@CadenceHealth.org

Rush-Copley Healthcare Center
Yorkville, Illinois 60560
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Deaconess Clinic Downtown
Evansville, Indiana 47713
Contact:
Site Public Contact
877-654-0311
Research@Deaconess.com

Parkview Regional Medical Center
Fort Wayne, Indiana 46845
Contact:
Site Public Contact
877-784-4673

Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

Sidney and Lois Eskenazi Hospital
Indianapolis, Indiana 46202
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

Community Cancer Center East
Indianapolis, Indiana 46219
Contact:
Site Public Contact
800-777-7775
lcheri@ecommunity.com

Community Cancer Center South
Indianapolis, Indiana 46227
Contact:
Site Public Contact
317-497-2823
lcheri@ecommunity.com

Community Cancer Center North
Indianapolis, Indiana 46256
Contact:
Site Public Contact
317-621-7104
lcheri@ecommunity.com

Springmill Medical Center
Indianapolis, Indiana 46290
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

Community Howard Regional Health
Kokomo, Indiana 46904
Contact:
Site Public Contact
765-453-8571
oncology@communityhoward.org

Chancellor Center for Oncology
Newburgh, Indiana 47630
Contact:
Site Public Contact
877-654-0311
Research@Deaconess.com

Memorial Hospital of South Bend
South Bend, Indiana 46601
Contact:
Site Public Contact
800-284-7370

Mary Greeley Medical Center
Ames, Iowa 50010
Contact:
Site Public Contact
515-956-4132

McFarland Clinic PC - Ames
Ames, Iowa 50010
Contact:
Site Public Contact
515-956-4132

University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf, Iowa 52722
Contact:
Site Public Contact
563-355-7733
kedaprile@rccqc.com

McFarland Clinic PC-Boone
Boone, Iowa 50036
Contact:
Site Public Contact
515-956-4132

Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa 52402
Contact:
Site Public Contact
319-297-2900
cetscheidt@pcofiowa.com

Mercy Hospital
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-365-4673

Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-363-2690

Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa 50325
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Genesis Medical Center - East Campus
Davenport, Iowa 52803
Contact:
Site Public Contact
563-421-1908
turnerk@genesishealth.com

Iowa Cancer Specialists
Davenport, Iowa 52804
Contact:
Site Public Contact
563-421-1908
turnerk@genesishealth.com

Iowa Methodist Medical Center
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-241-6727

Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-282-2921

Broadlawns Medical Center
Des Moines, Iowa 50314
Contact:
Site Public Contact
515-282-2200

Medical Oncology and Hematology Associates-Laurel
Des Moines, Iowa 50314
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

McFarland Clinic PC-Trinity Cancer Center
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-956-4132

Trinity Regional Medical Center
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-574-8302

University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Contact:
Site Public Contact
800-237-1225

McFarland Clinic PC-Jefferson
Jefferson, Iowa 50129
Contact:
Site Public Contact
515-956-4132

McFarland Clinic PC-Marshalltown
Marshalltown, Iowa 50158
Contact:
Site Public Contact
515-956-4132

Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Central Care Cancer Center - Garden City
Garden City, Kansas 67846
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

Hays Medical Center
Hays, Kansas 67601
Contact:
Site Public Contact
785-623-5774

University of Kansas Cancer Center
Kansas City, Kansas 66160
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Lawrence Memorial Hospital
Lawrence, Kansas 66044
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Kansas Institute of Medicine Cancer and Blood Center
Lenexa, Kansas 66219
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

Olathe Medical Center
Olathe, Kansas 66061
Contact:
Site Public Contact
913-791-3500
Jeni.wakefield@olathehealth.org

University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Via Christi Hospital-Pittsburg
Pittsburg, Kansas 66762
Contact:
Site Public Contact
620-235-7900

Salina Regional Health Center
Salina, Kansas 67401
Contact:
Site Public Contact
785-452-7038
kkavoura@srhc.com

Saint Francis Hospital and Medical Center - Topeka
Topeka, Kansas 66606
Contact:
Site Public Contact
785-295-8000

University of Kansas Hospital-Westwood Cancer Center
Westwood, Kansas 66205
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas 67208
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Cancer Center of Kansas - Wichita
Wichita, Kansas 67214
Contact:
Site Public Contact
316-268-5374
Keisha.humphries@ascension.org

Flaget Memorial Hospital
Bardstown, Kentucky 40004
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Baptist Health Corbin
Corbin, Kentucky 40701
Contact:
Site Public Contact
859-523-1934

Baptist Health Lexington
Lexington, Kentucky 40503
Contact:
Site Public Contact
859-260-6425

Saint Joseph London
London, Kentucky 40741
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana 70805
Contact:
Site Public Contact
225-215-1353
clinicalresearch@marybird.com

Hematology/Oncology Clinic LLP
Baton Rouge, Louisiana 70809
Contact:
Site Public Contact
225-767-0822

Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana 70809
Contact:
Site Public Contact
225-215-1353
clinicalresearch@marybird.com

Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809
Contact:
Site Public Contact
225-215-1353
clinicalresearch@marybird.com

Ochsner Health Center-Summa
Baton Rouge, Louisiana 70809
Contact:
Site Public Contact
225-761-5346
Camille.Beck@Ochsner.org

Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge, Louisiana 70809
Contact:
Site Public Contact
225-757-0343
clinicalresearch@marybird.com

Medical Center of Baton Rouge
Baton Rouge, Louisiana 70816
Contact:
Site Public Contact
225-761-5346
Camille.Beck@Ochsner.org

Woman's Hospital
Baton Rouge, Louisiana 70817
Contact:
Site Public Contact
protocols@swog.org

Northshore Oncology Associates-Covington
Covington, Louisiana 70433
Contact:
Site Public Contact
225-215-1353
clinicalresearch@marybird.com

Oncology Center of The South Incorporated
Houma, Louisiana 70360
Contact:
Site Public Contact
225-215-1353
clinicalresearch@marybird.com

Ochsner Medical Center Kenner
Kenner, Louisiana 70065
Contact:
Site Public Contact
504-464-8314
cris.molina@ochsner.org

East Jefferson General Hospital
Metairie, Louisiana 70006
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
Contact:
Site Public Contact
504-703-8712
Gregory.Johnstone@ochsner.org

Harold Alfond Center for Cancer Care
Augusta, Maine 04330
Contact:
Site Public Contact
207-626-4855

Waldo County General Hospital
Belfast, Maine 04915
Contact:
Site Public Contact
207-338-2500

MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford, Maine 04005
Contact:
Site Public Contact
LLemire@mmc.org

Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Contact:
Site Public Contact
800-987-3005

Stephens Memorial Hospital
Norway, Maine 04268
Contact:
Site Public Contact
207-396-8670
OncClinicalResearch@mmc.org

Penobscot Bay Medical Center
Rockport, Maine 04856
Contact:
Site Public Contact
207-921-8969

MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, Maine 04073
Contact:
Site Public Contact
LLemire@mmc.org

Maine Medical Partners - South Portland
South Portland, Maine 04106
Contact:
Site Public Contact
207-396-8670
ClinicalResearch@mmc.org

York Hospital
York, Maine 03909
Contact:
Site Public Contact
207-351-3777

Anne Arundel Medical Center
Annapolis, Maryland 21401
Contact:
Site Public Contact
443-481-1320
kbodenhorn@aahs.org

University of Maryland/Greenebaum Cancer Center
Baltimore, Maryland 21201
Contact:
Site Public Contact
800-888-8823

Greater Baltimore Medical Center
Baltimore, Maryland 21204
Contact:
Site Public Contact
443-849-3706

Saint Agnes Hospital
Baltimore, Maryland 21229
Contact:
Site Public Contact
410-368-2910

Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore, Maryland 21287
Contact:
Site Public Contact
410-955-8804
jhcccro@jhmi.edu

UM Upper Chesapeake Medical Center
Bel Air, Maryland 21014
Contact:
Site Public Contact
443-643-3010

Peninsula Regional Medical Center
Salisbury, Maryland 21801
Contact:
Site Public Contact
866-922-6237

UM Saint Joseph Medical Center
Towson, Maryland 21204
Contact:
Site Public Contact
410-337-4569
patriciajohnson@catholichealth.net

Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
Contact:
Site Public Contact
781-744-8027

Lowell General Hospital
Lowell, Massachusetts 01854
Contact:
Site Public Contact
978-788-7084
ghincks@lowellgeneral.org

Baystate Medical Center
Springfield, Massachusetts 01199
Contact:
Site Public Contact
413-794-3565
tamara.wrenn@baystatehealth.org

Winchester Hospital
Winchester, Massachusetts 01890
Contact:
Site Public Contact
protocols@swog.org

Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
Contact:
Site Public Contact
800-865-1125

Bronson Battle Creek
Battle Creek, Michigan 49017
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

IHA Hematology Oncology Consultants-Brighton
Brighton, Michigan 48114
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Joseph Mercy Brighton
Brighton, Michigan 48114
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 48183
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

IHA Hematology Oncology Consultants-Canton
Canton, Michigan 48188
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Joseph Mercy Canton
Canton, Michigan 48188
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

IHA Hematology Oncology Consultants-Chelsea
Chelsea, Michigan 48118
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Joseph Mercy Chelsea
Chelsea, Michigan 48118
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Henry Ford Macomb Hospital-Clinton Township
Clinton Township, Michigan 48038
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Henry Ford Medical Center-Fairlane
Dearborn, Michigan 48126
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Wayne State University/Karmanos Cancer Institute
Detroit, Michigan 48201
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Henry Ford Hospital
Detroit, Michigan 48202
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Ascension Saint John Hospital
Detroit, Michigan 48236
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan 48054
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Michigan State University Clinical Center
East Lansing, Michigan 48824-7016
Contact:
Site Public Contact
517-975-9547

Weisberg Cancer Treatment Center
Farmington Hills, Michigan 48334
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Beaumont Hospital - Farmington Hills
Farmington Hills, Michigan 48336
Contact:
Site Public Contact
248-551-7695

Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan 48503
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Genesee Hematology Oncology PC
Flint, Michigan 48503
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Genesys Hurley Cancer Institute
Flint, Michigan 48503
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Hurley Medical Center
Flint, Michigan 48503
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Mercy Health Saint Mary's
Grand Rapids, Michigan 49503
Contact:
Site Public Contact
protocols@swog.org

Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Academic Hematology Oncology Specialists
Grosse Pointe Woods, Michigan 48236
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan 48236
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

West Michigan Cancer Center
Kalamazoo, Michigan 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Sparrow Hospital
Lansing, Michigan 48912
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Mary Mercy Hospital
Livonia, Michigan 48154
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan 48044
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Mid-Michigan Medical Center - Midland
Midland, Michigan 48670
Contact:
Site Public Contact
989-839-1678
oncresearch@midmichigan.org

Mercy Health Mercy Campus
Muskegon, Michigan 49444
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Henry Ford Medical Center-Columbus
Novi, Michigan 48377
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Spectrum Health Reed City Hospital
Reed City, Michigan 49677
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Great Lakes Cancer Management Specialists-Rochester Hills
Rochester Hills, Michigan 48309
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

William Beaumont Hospital-Royal Oak
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695

Ascension Saint Mary's Hospital
Saginaw, Michigan 48601
Contact:
Site Public Contact
protocols@swog.org

Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Ascension Providence Hospitals - Southfield
Southfield, Michigan 48075
Contact:
Site Public Contact
248-849-5337
jaswinder.grewal@stjohn.org

Munson Medical Center
Traverse City, Michigan 49684
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

William Beaumont Hospital - Troy
Troy, Michigan 48085
Contact:
Site Public Contact
248-551-7695

Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan 48093
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Henry Ford West Bloomfield Hospital
West Bloomfield, Michigan 48322
Contact:
Site Public Contact
313-916-3721
CTOResearch@hfhs.org

Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
Contact:
Site Public Contact
989-343-2487

Metro Health Hospital
Wyoming, Michigan 49519
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

IHA Hematology Oncology Consultants-Ann Arbor
Ypsilanti, Michigan 48197
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
Contact:
Site Public Contact
218-333-5000
OncologyClinicalTrialsFargo@sanfordhealth.org

Essentia Health Saint Joseph's Medical Center
Brainerd, Minnesota 56401
Contact:
Site Public Contact
protocols@swog.org

Fairview Ridges Hospital
Burnsville, Minnesota 55337
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Mercy Hospital
Coon Rapids, Minnesota 55433
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Essentia Health Cancer Center
Duluth, Minnesota 55805
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Fairview-Southdale Hospital
Edina, Minnesota 55435
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Maple Grove Medical Center
Maple Grove, Minnesota 55369
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
Contact:
Site Public Contact
877-229-4907
coborncancercenter@centracare.com

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Regions Hospital
Saint Paul, Minnesota 55101
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

United Hospital
Saint Paul, Minnesota 55102
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Ridgeview Medical Center
Waconia, Minnesota 55387
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus, Mississippi 39705
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Cancer Center-Grenada
Grenada, Mississippi 38901
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Union County
New Albany, Mississippi 38652
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Baptist Memorial Hospital and Cancer Center-Oxford
Oxford, Mississippi 38655
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Singing River Hospital
Pascagoula, Mississippi 39581
Contact:
Site Public Contact
228-809-5292

Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Central Care Cancer Center - Bolivar
Bolivar, Missouri 65613
Contact:
Site Public Contact
800-328-6010
aroland@kccop.org

Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Contact:
Site Public Contact
573-334-2230
sfmc@sfmc.net

Capital Region Southwest Campus
Jefferson City, Missouri 65109
Contact:
Site Public Contact
573-632-4814
swooden@mail.crmc.org

Truman Medical Center
Kansas City, Missouri 64108
Contact:
Site Public Contact
816-404-4375

Research Medical Center
Kansas City, Missouri 64132
Contact:
Site Public Contact
913-948-5588
aroland@kccop.org

The University of Kansas Cancer Center-North
Kansas City, Missouri 64154
Contact:
Site Public Contact
913-945-7552
ctnursenav@kumc.edu

Heartland Regional Medical Center
Saint Joseph, Missouri 64507
Contact:
Site Public Contact
816-271-7937
linda.schumacher@mymlc.com

Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569

Community Hospital of Anaconda
Anaconda, Montana 59711
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Bozeman Deaconess Hospital
Bozeman, Montana 59715
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Kalispell Regional Medical Center
Kalispell, Montana 59901
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Community Medical Hospital
Missoula, Montana 59804
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

CHI Health Saint Francis
Grand Island, Nebraska 68803
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Nebraska Methodist Hospital
Omaha, Nebraska 68114
Contact:
Site Public Contact
402-354-5144

Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska 68124
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

University of Nebraska Medical Center
Omaha, Nebraska 68198
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Renown Regional Medical Center
Reno, Nevada 89502
Contact:
Site Public Contact
702-384-0013
research@sncrf.org

Saint Mary's Regional Medical Center
Reno, Nevada 89503
Contact:
Site Public Contact
protocols@swog.org

New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire 03301
Contact:
Site Public Contact
603-224-2556

New Hampshire Oncology Hematology PA-Hooksett
Hooksett, New Hampshire 03106
Contact:
Site Public Contact
800-339-6484

Dartmouth Hitchcock Medical Center
Lebanon, New Hampshire 03756
Contact:
Site Public Contact
800-639-6918
cancer.research.nurse@dartmouth.edu

Norris Cotton Cancer Center-Manchester
Manchester, New Hampshire 03102
Contact:
Site Public Contact
603-629-1828

Norris Cotton Cancer Center-Nashua
Nashua, New Hampshire 03063
Contact:
Site Public Contact
603-577-4282
Laura.A.Menken@hitchcock.org

Hackensack University Medical Center
Hackensack, New Jersey 07601
Contact:
Site Public Contact
201-996-2879

The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey 08690
Contact:
Site Public Contact
609-631-6946

Saint Barnabas Medical Center
Livingston, New Jersey 07039
Contact:
Site Public Contact
973-322-2934
joanne.loeb@rwjbh.org

Monmouth Medical Center
Long Branch, New Jersey 07740
Contact:
Site Public Contact
732-923-7689

Virtua Memorial
Mount Holly, New Jersey 08060
Contact:
Site Public Contact
609-914-6762

Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08903
Contact:
Site Public Contact
732-235-8675

Newark Beth Israel Medical Center
Newark, New Jersey 07112
Contact:
Site Public Contact
973-926-7230

MD Anderson Cancer Center at Cooper-Voorhees
Voorhees, New Jersey 08043
Contact:
Site Public Contact
856-325-6757

Lovelace Medical Center-Saint Joseph Square
Albuquerque, New Mexico 87102
Contact:
Site Public Contact
505-272-0530
AYost@nmcca.org

University of New Mexico Cancer Center
Albuquerque, New Mexico 87102
Contact:
Site Public Contact
505-925-0366
LByatt@nmcca.org

New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico 87109
Contact:
Site Public Contact
505-272-0530
CLee@nmcca.org

Presbyterian Kaseman Hospital
Albuquerque, New Mexico 87110
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Memorial Medical Center - Las Cruces
Las Cruces, New Mexico 88011
Contact:
Site Public Contact
575-556-6545
Kim.Hoffman@lpnt.net

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho, New Mexico 87124
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Christus Saint Vincent Regional Cancer Center
Santa Fe, New Mexico 87505
Contact:
Site Public Contact
505-913-8933
Olivia.Sloan@nmcancercare.com

Montefiore Medical Center-Einstein Campus
Bronx, New York 10461
Contact:
Site Public Contact
718-379-6866
aaraiza@montefiore.org

Montefiore Medical Center-Weiler Hospital
Bronx, New York 10461
Contact:
Site Public Contact
718-379-6866
aaraiza@montefiore.org

Montefiore Medical Center - Moses Campus
Bronx, New York 10467
Contact:
Site Public Contact
718-379-6866
aaraiza@montefiore.org

Roswell Park Cancer Institute
Buffalo, New York 14263
Contact:
Site Public Contact
800-767-9355
askroswell@roswellpark.org

Arnot Ogden Medical Center/Falck Cancer Center
Elmira, New York 14905
Contact:
Site Public Contact
607-271-7000

NYU Winthrop Hospital
Mineola, New York 11501
Contact:
Site Public Contact
866-946-8476

Mount Sinai Union Square
New York, New York 10003
Contact:
Site Public Contact
212-844-6286
CCTO@mssm.edu

Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
Contact:
Site Public Contact
212-263-4434
prmc.coordinator@nyumc.org

Mount Sinai West
New York, New York 10019
Contact:
Site Public Contact
212-523-4000
CCTO@mssm.edu

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York 10032
Contact:
Site Public Contact
212-305-6361
nr2616@cumc.columbia.edu

NYP/Weill Cornell Medical Center
New York, New York 10065
Contact:
Site Public Contact
212-746-1848

University of Rochester
Rochester, New York 14642
Contact:
Site Public Contact
585-275-5830

Staten Island University Hospital
Staten Island, New York 10305
Contact:
Site Public Contact
718-226-8888

Stony Brook University Medical Center
Stony Brook, New York 11794
Contact:
Site Public Contact
800-862-2215

State University of New York Upstate Medical University
Syracuse, New York 13210
Contact:
Site Public Contact
315-464-5476

Dickstein Cancer Treatment Center
White Plains, New York 10601
Contact:
Site Public Contact
914-849-7582
mcortese@wphospital.org

Atrium Health Stanly/LCI-Albemarle
Albemarle, North Carolina 28002
Contact:
Site Public Contact
800-804-9376

Randolph Hospital
Asheboro, North Carolina 27203
Contact:
Site Public Contact
336-832-0836
vivian.sheidler@conehealth.com

Mission Hospital Inc-Memorial Campus
Asheville, North Carolina 28801
Contact:
Site Public Contact
828-213-4150
leslie.verner@msj.org

Hope Women's Cancer Centers-Asheville
Asheville, North Carolina 28816
Contact:
Site Public Contact
protocols@swog.org

Cone Health Cancer Center at Alamance Regional
Burlington, North Carolina 27215
Contact:
Site Public Contact
336-538-7725
kaye.shoffner@conehealth.com

UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
Contact:
Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu

Carolinas Medical Center/Levine Cancer Institute
Charlotte, North Carolina 28203
Contact:
Site Public Contact
800-804-9376

Levine Cancer Institute-Tryon
Charlotte, North Carolina 28203
Contact:
Site Public Contact
800-804-9376

Novant Health Presbyterian Medical Center
Charlotte, North Carolina 28204
Contact:
Site Public Contact
704-384-5369
nnechiporchik@novanthealth.org

Oncology Specialists of Charlotte
Charlotte, North Carolina 28207
Contact:
Site Public Contact
704-384-8920
nnechiporchik@novanthealth.org

Atrium Health Pineville/LCI-Pineville
Charlotte, North Carolina 28210
Contact:
Site Public Contact
800-804-9376

Southeastern Medical Oncology Center-Clinton
Clinton, North Carolina 28328
Contact:
Site Public Contact
919-587-9077
ecooke@cancersmoc.com

Atrium Health Cabarrus/LCI-Concord
Concord, North Carolina 28025
Contact:
Site Public Contact
704-403-1520

Southeastern Medical Oncology Center-Goldsboro
Goldsboro, North Carolina 27534
Contact:
Site Public Contact
919-587-9077
ecooke@cancersmoc.com

Cone Health Cancer Center
Greensboro, North Carolina 27403
Contact:
Site Public Contact
336-832-0821
vivian.sheidler@conehealth.com

Margaret R Pardee Memorial Hospital
Hendersonville, North Carolina 28791
Contact:
Site Public Contact
828-696-4716
karen.morris@unchealth.unc.edu

Lake Norman Hematology Oncology Specialists-Huntersville
Huntersville, North Carolina 28078
Contact:
Site Public Contact
704-384-8920
nnechiporchik@novanthealth.org

Southeastern Medical Oncology Center-Jacksonville
Jacksonville, North Carolina 28546
Contact:
Site Public Contact
910-353-0824
ecooke@cancersmoc.com

Novant Health Oncology Specialists-Kernersville
Kernersville, North Carolina 27284
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Novant Health Cancer Specialists-Matthews
Matthews, North Carolina 28105
Contact:
Site Public Contact
704-384-8920
nnechiporchik@novanthealth.org

Lake Norman Hematology Oncology Specialists-Mooresville
Mooresville, North Carolina 28117
Contact:
Site Public Contact
704-384-8920
nnechiporchik@novanthealth.org

Novant Health Oncology Specialists-Mount Airy
Mount Airy, North Carolina 27030
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina 28374
Contact:
Site Public Contact
910-715-3500
jcwilliams@firsthealth.org

Novant Health Oncology Specialists-Statesville
Statesville, North Carolina 28625
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Novant Health Oncology Specialists-Davidson County
Thomasville, North Carolina 27360
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Novant Health Oncology Specialists-Wilkesboro
Wilkesboro, North Carolina 28659
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Novant Health Forsyth Medical Center
Winston-Salem, North Carolina 27103
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Novant Health Oncology Specialists
Winston-Salem, North Carolina 27103
Contact:
Site Public Contact
336-718-8335
asmarrs@novanthealth.org

Wake Forest University Health Sciences
Winston-Salem, North Carolina 27157
Contact:
Site Public Contact
336-713-6771

Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Essentia Health Cancer Center-South University Clinic
Fargo, North Dakota 58103
Contact:
Site Public Contact
218-786-3308
CancerTrials@EssentiaHealth.org

Sanford Broadway Medical Center
Fargo, North Dakota 58122
Contact:
Site Public Contact
701-323-5760
OncologyClinicalTrialsFargo@sanfordhealth.org

Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
Contact:
Site Public Contact
701-234-6161
OncologyClinicalTrialsFargo@sanfordhealth.org

Strecker Cancer Center-Belpre
Belpre, Ohio 45714
Contact:
Site Public Contact
800-523-3977
sheree@columbusccop.org

Mercy Medical Center
Canton, Ohio 44708
Contact:
Site Public Contact
888-293-4673

Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Adena Regional Medical Center
Chillicothe, Ohio 45601
Contact:
Site Public Contact
877-779-7585
sheree@columbusccop.org

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Cleveland Clinic Foundation
Cleveland, Ohio 44195
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Contact:
Site Public Contact
800-293-5066
Jamesline@osumc.edu

Columbus Oncology and Hematology Associates Inc
Columbus, Ohio 43214
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Grant Medical Center
Columbus, Ohio 43215
Contact:
Site Public Contact
614-566-4475
sheree@columbusccop.org

The Mark H Zangmeister Center
Columbus, Ohio 43219
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Doctors Hospital
Columbus, Ohio 43228
Contact:
Site Public Contact
614-566-3275
sheree@columbusccop.org

Delaware Health Center-Grady Cancer Center
Delaware, Ohio 43015
Contact:
Site Public Contact
740-615-0227
sheree@columbusccop.org

Dayton Physicians LLC-Atrium
Franklin, Ohio 45005
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Marietta Memorial Hospital
Marietta, Ohio 45750
Contact:
Site Public Contact
800-523-3977
sheree@columbusccop.org

OhioHealth Marion General Hospital
Marion, Ohio 43302
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Licking Memorial Hospital
Newark, Ohio 43055
Contact:
Site Public Contact
740-348-4000
sheree@columbusccop.org

Mercy Health Perrysburg Cancer Center
Perrysburg, Ohio 43551
Contact:
Site Public Contact
419-479-5605
pshoup@toledoclinic.com

Southern Ohio Medical Center
Portsmouth, Ohio 45662
Contact:
Site Public Contact
614-488-2118
sheree@columbusccop.org

North Coast Cancer Care
Sandusky, Ohio 44870
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Springfield Regional Medical Center
Springfield, Ohio 45505
Contact:
Site Public Contact
937-775-1350
som_dcop@wright.edu

Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

ProMedica Flower Hospital
Sylvania, Ohio 43560
Contact:
Site Public Contact
419-824-1842

Mercy Saint Anne Hospital
Toledo, Ohio 43623
Contact:
Site Public Contact
419-407-1160

Toledo Clinic Cancer Centers-Toledo
Toledo, Ohio 43623
Contact:
Site Public Contact
800-444-3561

South Pointe Hospital
Warrensville Heights, Ohio 44122
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
Contact:
Site Public Contact
866-223-8100
CancerAnswer@ccf.org

Genesis Healthcare System Cancer Care Center
Zanesville, Ohio 43701
Contact:
Site Public Contact
740-454-5232
sheree@columbusccop.org

Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
Contact:
Site Public Contact
877-231-4440

University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa, Oklahoma 74146
Contact:
Site Public Contact
918-505-3200

Good Samaritan Hospital
Corvallis, Oregon 97330
Contact:
Site Public Contact
541-768-4352
stmock@samhealth.org

Legacy Mount Hood Medical Center
Gresham, Oregon 97030
Contact:
Site Public Contact
503-413-2150

Saint Alphonsus Medical Center-Ontario
Ontario, Oregon 97914
Contact:
Site Public Contact
734-712-3671
stephanie.couch@stjoeshealth.org

Legacy Good Samaritan Hospital and Medical Center
Portland, Oregon 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Providence Portland Medical Center
Portland, Oregon 97213
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Portland, Oregon 97225
Contact:
Site Public Contact
503-215-2614
CanRsrchStudies@providence.org

Kaiser Permanente Northwest
Portland, Oregon 97227
Contact:
Site Public Contact
503-335-2400
information@kpchr.org

Oregon Health and Science University
Portland, Oregon 97239
Contact:
Site Public Contact
503-494-1080
trials@ohsu.edu

Legacy Meridian Park Hospital
Tualatin, Oregon 97062
Contact:
Site Public Contact
503-413-1742

Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Saint Vincent Hospital
Erie, Pennsylvania 16544
Contact:
Site Public Contact
814-452-5000

UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109
Contact:
Site Public Contact
717-724-6765
klitchfield@PINNACLEHEALTH.org

Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

Riddle Memorial Hospital
Media, Pennsylvania 19063
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Forbes Hospital
Monroeville, Pennsylvania 15146
Contact:
Site Public Contact
412-858-7746

Paoli Memorial Hospital
Paoli, Pennsylvania 19301
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Contact:
Site Public Contact
215-955-6084

Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
Contact:
Site Public Contact
877-284-2000

West Penn Hospital
Pittsburgh, Pennsylvania 15224
Contact:
Site Public Contact
412-578-5000

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-647-8073

Chester County Hospital
West Chester, Pennsylvania 19380
Contact:
Site Public Contact
610-431-5297

Reading Hospital
West Reading, Pennsylvania 19611
Contact:
Site Public Contact
610-988-9323

Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

Abington Memorial Hospital-Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
Contact:
Site Public Contact
215-481-2402

Lankenau Medical Center
Wynnewood, Pennsylvania 19096
Contact:
Site Public Contact
484-476-2649
turzoe@mlhs.org

AnMed Health Cancer Center
Anderson, South Carolina 29621
Contact:
Site Public Contact
864-512-4651
rhonda.ballew@anmedhealth.org

Medical University of South Carolina
Charleston, South Carolina 29425
Contact:
Site Public Contact
843-792-9321
hcc-clinical-trials@musc.edu

Greenville Health System Cancer Institute-Easley
Easley, South Carolina 29640
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

McLeod Regional Medical Center
Florence, South Carolina 29506
Contact:
Site Public Contact
843-777-6387
jcapotosti@mcleodhealth.org

Saint Francis Hospital
Greenville, South Carolina 29601
Contact:
Site Public Contact
864-603-6213
meissa_beckman@bshsi.org

Greenville Health System Cancer Institute-Butternut
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

Greenville Health System Cancer Institute-Faris
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

Saint Francis Cancer Center
Greenville, South Carolina 29607
Contact:
Site Public Contact
864-603-6213
meissa_beckman@bshsi.org

Greenville Health System Cancer Institute-Eastside
Greenville, South Carolina 29615
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

Self Regional Healthcare
Greenwood, South Carolina 29646
Contact:
Site Public Contact
864-725-4771
nmcgaha@selfregional.org

Greenville Health System Cancer Institute-Greer
Greer, South Carolina 29650
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

Gibbs Cancer Center-Pelham
Greer, South Carolina 29651
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

South Carolina Cancer Specialists PC
Hilton Head Island, South Carolina 29926-3827
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Levine Cancer Institute-Rock Hill
Rock Hill, South Carolina 29732
Contact:
Site Public Contact
800-804-9376

Greenville Health System Cancer Institute-Seneca
Seneca, South Carolina 29672
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

Spartanburg Medical Center
Spartanburg, South Carolina 29303
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Greenville Health System Cancer Institute-Spartanburg
Spartanburg, South Carolina 29307
Contact:
Site Public Contact
864-241-6251
kwilliams8@ghs.org

MGC Hematology Oncology-Union
Union, South Carolina 29379
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Lexington Medical Center
West Columbia, South Carolina 29169
Contact:
Site Public Contact
803-936-8050

Rapid City Regional Hospital
Rapid City, South Dakota 57701
Contact:
Site Public Contact
605-716-3982
research@rcrh.org

Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Contact:
Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org

Avera Cancer Institute
Sioux Falls, South Dakota 57105
Contact:
Site Public Contact
888-634-7268
oncregulatory@avera.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

Baptist Memorial Hospital and Cancer Center-Collierville
Collierville, Tennessee 38017
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Regional Cancer Center at Indian Path Community Hospital
Kingsport, Tennessee 37660
Contact:
Site Public Contact
423-578-8538
Justin.reynolds@balladhealth.org

Thompson Cancer Survival Center
Knoxville, Tennessee 37916
Contact:
Site Public Contact
865-331-1812

Thompson Cancer Survival Center - West
Knoxville, Tennessee 37932
Contact:
Site Public Contact
865-331-1812

Thompson Oncology Group-Lenoir City
Lenoir City, Tennessee 37772
Contact:
Site Public Contact
865-331-1812

Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Contact:
Site Public Contact
901-226-1366
BCCclintrials@bmhcc.org

Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
Contact:
Site Public Contact
800-811-8480

Thompson Oncology Group-Oak Ridge
Oak Ridge, Tennessee 37830
Contact:
Site Public Contact
865-331-1812

The Don and Sybil Harrington Cancer Center
Amarillo, Texas 79106
Contact:
Site Public Contact
806-212-1985
gcravey@harringtoncc.org

Dell Seton Medical Center at The University of Texas
Austin, Texas 78701
Contact:
Site Public Contact
512-324-7991

Austin Cancer Centers-Central Austin
Austin, Texas 78702
Contact:
Site Public Contact
lsansalone@austincancercenters.com

Austin Cancer Centers-Central Park
Austin, Texas 78705
Contact:
Site Public Contact
512-354-6391
lsansalone@austincancercenters.com

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas 77030
Contact:
Site Public Contact
713-798-1354
burton@bcm.edu

Ben Taub General Hospital
Houston, Texas 77030
Contact:
Site Public Contact
713-873-2000

M D Anderson Cancer Center
Houston, Texas 77030
Contact:
Site Public Contact
877-312-3961

The Methodist Hospital System
Houston, Texas 77030
Contact:
Site Public Contact
713-790-2700

Houston Methodist Sugar Land Hospital
Sugar Land, Texas 77479
Contact:
Site Public Contact
281-242-2873

Farmington Health Center
Farmington, Utah 84025
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

South Jordan Health Center
South Jordan, Utah 84009
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Norris Cotton Cancer Center-North
Saint Johnsbury, Vermont 05819
Contact:
Site Public Contact
802-473-4100

Wellmont Medical Associates-Bristol
Bristol, Virginia 24201
Contact:
Site Public Contact
423-578-8538
justin.reynolds@wellmont.org

IMG Hematology Oncology 8501
Fairfax, Virginia 22031
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Centra Lynchburg Hematology-Oncology Clinic Inc
Lynchburg, Virginia 24501
Contact:
Site Public Contact
434-200-5925
Kevin.Patel@centrahealth.com

Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
Contact:
Site Public Contact
804-893-8611
Melissa_Godsey@bshsi.org

Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
Contact:
Site Public Contact
804-893-8611
Melissa_Godsey@bshsi.org

Peninsula Cancer Institute-Newport News
Newport News, Virginia 23601
Contact:
Site Public Contact
757-534-5565
oramae.jackson@rivhs.com

Southwest VA Regional Cancer Center
Norton, Virginia 24273
Contact:
Site Public Contact
423-578-8538
justin.reynolds@wellmont.org

Bon Secours Saint Mary's Hospital
Richmond, Virginia 23226
Contact:
Site Public Contact
protocols@swog.org

Virginia Cancer Institute
Richmond, Virginia 23230
Contact:
Site Public Contact
804-287-3000
david.trent@comcast.net

Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
Contact:
Site Public Contact
mwellons@vcu.edu

Peninsula Cancer Institute-Cancer Specialists of Tidewater
Virginia Beach, Virginia 23454
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Shenandoah Oncology PC
Winchester, Virginia 22601
Contact:
Site Public Contact
540-662-1108
William.Houck@usoncology.com

Swedish Medical Center-Edmonds
Edmonds, Washington 98026
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Seattle Cancer Care Alliance at EvergreenHealth
Kirkland, Washington 98034
Contact:
Site Public Contact
425-899-6000

Jefferson Healthcare
Port Townsend, Washington 98368
Contact:
Site Public Contact
360-344-3091

Harrison HealthPartners Hematology and Oncology-Poulsbo
Poulsbo, Washington 98370
Contact:
Site Public Contact
308-398-6518
clinicaltrials@sfmc-gi.org

Seattle Cancer Care Alliance
Seattle, Washington 98109
Contact:
Site Public Contact
800-804-8824

Swedish Medical Center-First Hill
Seattle, Washington 98122-4307
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Seattle Cancer Care Alliance at Northwest Hospital
Seattle, Washington 98133
Contact:
Site Public Contact
206-606-5800

Legacy Salmon Creek Hospital
Vancouver, Washington 98686
Contact:
Site Public Contact
503-413-2150

Edwards Comprehensive Cancer Center
Huntington, West Virginia 25701
Contact:
Site Public Contact
304-399-6617

Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Contact:
Site Public Contact
715-623-9869
Juli.Alford@aspirus.org

Wheaton Franciscan Healthcare-Elmbrook Memorial Hospital
Brookfield, Wisconsin 53045
Contact:
Site Public Contact
262-687-5010
Michelle.czechowicz@ascension.org

Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Health Center-Fond du Lac
Fond Du Lac, Wisconsin 54937
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Wheaton Franciscan Healthcare-Saint Francis/Reiman Cancer Center
Franklin, Wisconsin 53132
Contact:
Site Public Contact
262-687-5010
Michelle.czechowicz@ascension.org

Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Contact:
Site Public Contact
920-433-8889
Christy.Gilchrist@hshs.org

Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Contact:
Site Public Contact
protocols@swog.org

Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

UW Cancer Center Johnson Creek
Johnson Creek, Wisconsin 53038
Contact:
Site Public Contact
920-699-3500
lynda.persico@uwmf.wisc.edu

Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
Contact:
Site Public Contact
608-775-2385
cancerctr@gundersenhealth.org

University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
Contact:
Site Public Contact
800-622-8922

Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Saint Vincent Hospital Cancer Center at Marinette
Marinette, Wisconsin 54143
Contact:
Site Public Contact
920-433-8889
Christy.Gilchrist@hshs.org

Columbia Saint Mary's Hospital - Ozaukee
Mequon, Wisconsin 53097
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Columbia Saint Mary's Water Tower Medical Commons
Milwaukee, Wisconsin 53211
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Contact:
Site Public Contact
888-823-5923
ctsucontact@westat.com

Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
Contact:
Site Public Contact
research.institute@phci.org

Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Contact:
Site Public Contact
262-928-7878

Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
Contact:
Site Public Contact
920-433-8889
Christy.Gilchrist@hshs.org

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Wheaton Franciscan Cancer Care - All Saints
Racine, Wisconsin 53405
Contact:
Site Public Contact
262-687-5010
Michelle.czechowicz@ascension.org

Aurora Cancer Care-Racine
Racine, Wisconsin 53406
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
Contact:
Site Public Contact
920-433-8889
Christy.Gilchrist@hshs.org

Aurora Medical Center in Summit
Summit, Wisconsin 53066
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
Contact:
Site Public Contact
262-928-7632

UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Contact:
Site Public Contact
262-928-5539
Chanda.miller@phci.org

Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Contact:
Site Public Contact
877-405-6866

Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Wheaton Franciscan Healthcare-Saint Joseph/Wauwatosa Campus
Wauwatosa, Wisconsin 53226
Contact:
Site Public Contact
262-687-5010
Michelle.czechowicz@ascension.org

Aurora West Allis Medical Center
West Allis, Wisconsin 53227
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aspirus UW Cancer Center
Wisconsin Rapids, Wisconsin 54494
Contact:
Site Public Contact
715-422-7718

Cancer Center-Metro Medical Center Bayamon
Bayamon, Puerto Rico 00959-5060
Contact:
Site Public Contact
787-395-7085

Doctors Cancer Center
Manati, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397

San Juan Community Oncology Group
San Juan, Puerto Rico 00917
Contact:
Site Public Contact
787-274-3387

San Juan City Hospital
San Juan, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296

More Details

NCT ID
NCT02954874
Status
Recruiting
Sponsor
National Cancer Institute (NCI)

Detailed Description

PRIMARY OBJECTIVES:

I. To compare invasive disease-free survival (IDFS) of patients with triple-negative breast cancer (TNBC) who have either >= 1 cm residual invasive breast cancer and/or positive lymph nodes (> ypN+) after neoadjuvant chemotherapy randomized to receive 1 year of MK-3475 (pembrolizumab) adjuvant therapy compared to no MK-3475 (pembrolizumab), in both the entire study population and also in the PD-L1 positive subset.

SECONDARY OBJECTIVES:

I. To compare the effects of MK-3475 (pembrolizumab) on overall survival (OS) and distant recurrence-free survival (DRFS) between the two randomized arms for the PD-L1 positive patients and then all patients.

II. To assess the toxicity and tolerability of MK-3475 (pembrolizumab) in this patient population with or without radiation therapy.

TERTIARY OBJECTIVES:

I. To examine the association between biomarkers of inflammation and quality of life and patient reported outcomes between the two groups during and at the end of therapy.

II. To examine the long-term and late effects of treatment on patient-reported outcomes.

III. To collect tissue and whole blood for processing and banking in anticipation of future correlative studies in this patient population.

OUTLINE: Patients are randomized to 1 of 2 arms.

ARM I (OBSERVATION): Patients receive no treatment but are monitored at standard clinical intervals during first year after randomization. Patients are examined every 12 weeks for 1 year, and every 6 months for 4 years, then annually for 5 years.

ARM II (PEMROLIZUMAB): Patients receive pembrolizumab intravenously (IV) over 30 minutes on days 1 and 22. Courses repeat every 42 days for 52 weeks in the absence of disease progression or unacceptable toxicity.

All patients may undergo radiation therapy within 12 weeks of last breast cancer operation or after treatment.

After completion of study treatment, patients are followed up to 10 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.