Active Surveillance, Bleomycin, Etoposide, Carboplatin or Cisplatin in Treating Pediatric and Adult Patients With Germ Cell Tumors
Purpose
This phase III trial studies how well active surveillance help doctors to monitor subjects with low risk germ cell tumors for recurrence after their tumor is removed. When the germ cell tumor has spread outside of the organ in which it developed, it is considered metastatic. Chemotherapy drugs, such as bleomycin, carboplatin, etoposide, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. The trial studies whether carboplatin or cisplatin is the preferred chemotherapy to use in treating metastatic standard risk germ cell tumors.
Conditions
- Childhood Extracranial Germ Cell Tumor
- Extragonadal Embryonal Carcinoma
- Germ Cell Tumor
- Malignant Germ Cell Tumor
- Malignant Ovarian Teratoma
- Stage I Ovarian Choriocarcinoma
- Stage I Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage I Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage I Testicular Choriocarcinoma AJCC v6 and v7
- Stage I Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage I Testicular Seminoma AJCC v6 and v7
- Stage I Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage II Ovarian Choriocarcinoma
- Stage II Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage II Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage II Testicular Choriocarcinoma AJCC v6 and v7
- Stage II Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage II Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage III Ovarian Choriocarcinoma
- Stage III Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage III Ovarian Yolk Sac Tumor AJCC v6 and v7
- Stage III Testicular Choriocarcinoma AJCC v6 and v7
- Stage III Testicular Embryonal Carcinoma AJCC v6 and v7
- Stage III Testicular Yolk Sac Tumor AJCC v6 and v7
- Stage IV Ovarian Choriocarcinoma
- Stage IV Ovarian Embryonal Carcinoma AJCC v6 and v7
- Stage IV Ovarian Yolk Sac Tumor AJCC v6 and v7
- Testicular Mixed Choriocarcinoma and Embryonal Carcinoma
- Testicular Mixed Choriocarcinoma and Teratoma
- Testicular Mixed Choriocarcinoma and Yolk Sac Tumor
Eligibility
- Eligible Ages
- All ages
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- There is no age limit for the low risk stratum (stage I ovarian immature teratoma and stage I non-seminoma or seminoma malignant GCT [all sites]) - Standard risk 1: Patients must be < 11 years of age at enrollment - Standard risk 2: Patients must be >= 11 and < 25 years of age at enrollment - Patients enrolling on one of the low risk arms must be newly diagnosed with a stage I germ cell tumor; for the standard risk arms, patients must be newly diagnosed with malignant germ cell tumor (stage II or higher). - Histologic confirmation of a primary extracranial germ cell tumor in any of the categories outlined below is required of all patients at enrollment , with the following exceptions: - Among patients were initially diagnosed with completely resected non-seminoma malignant GCT and later recur during observation post surgery, a diagnostic biopsy is not required for enrollment if elevated tumor markers rise to > 5 x upper limit of normal (ULN) on at least 2 measurements taken at least 1 week apart. The pathology report of initial surgery should be provided - Patients may be enrolled without histologic or cytologic confirmation in the rare case where there are exceptionally raised tumor markers (alpha fetoprotein [AFP- ≥ 500 ng/mL or HCG ≥ 500 IU/L) and radiologic features consistent with GCT. In addition, the treating clinician must deem that the patient's tumor is not suitable for upfront resection and that a biopsy is not in the patient's best interest; or that there is a need to start therapy urgently - Low risk immature teratoma (IT); site: ovarian; stage: any; grade: any; histology: pure immature teratoma, mixed immature and mature teratoma, (may contain microscopic foci of yolk sac tumor [< 3 mm], but no other pathological evidence of MGCT); tumor markers: alpha-FP =< 1,000 ng/mL, beta-HCG institutional normal; all ages - Low risk stage I non-seminoma MGCT; site: ovarian, testicular, or extragonadal; stage: COG stage I, FIGO stage IA and IB, American Joint Committee on Cancer (AJCC) testicular stage IA, IB and IS; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma (pure or mixed); all ages - Low risk stage I seminoma-MGCT; site: testicular; stage: COG stage I; AJCC testicular stage IA IB, and IS; histology: must contain only seminoma; may contain immature/mature teratoma; may NOT contain yolk sac tumor, embryonal carcinoma, or choriocarcinoma; all ages - Standard risk 1 (SR1); site: ovarian, testicular, or extragonadal; stage: COG stage II-IV, FIGO stage IC-IV, (International Germ Cell Consensus Classification [IGCCC] criteria DO NOT apply); histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) < 11 - Standard risk 2 (SR2) - Site: ovarian; stage: COG stage II, III, and III-X, FIGO stage IC, II and III; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma; age (years) >= 11 and < 25 - Site: testicular; stage: COG stage II-IV, AJCC stage II, III, IGCCC good risk; histology: must contain at least one of the following: yolk sac tumor, embryonal carcinoma, or choriocarcinoma: must be IGCCC good risk; post op: alpha-FP < 1,000 ng/mL, beta-HCG < 5,000 IU/mL and lactate dehydrogenase (LDH) < 3.0 x normal; age (years) >= 11 and < 25 - Notes: - IGCCC criteria only apply to SR2 patients with a testicular primary tumor - Use post-op tumor marker levels to determine IGCCC risk group - Pure seminoma patients are not eligible for the standard risk arms of the study - For the low risk stage I non-seminoma MGCT and the standard risk arms, components of yolk sac tumor, embryonal carcinoma, or choriocarcinoma can be mixed with other forms of GCT, such as seminoma or mature or immature teratoma; if yolk sac tumor is the only malignant component present, then it must be deemed by the pathologist to be greater than a "microscopic component" of yolk sac tumor - Patients must have a performance status corresponding to Eastern Cooperative Oncology Group (ECOG) scores of 0, 1, 2 or 3; use Karnofsky for patients > 16 years of age and Lansky for patients =< 16 years of age - Organ function requirements apply ONLY to patients who will receive chemotherapy (SR1 and SR2 patients) - Adequate renal function defined as: - Creatinine clearance or radioisotope glomerular filtration rate (GFR) >= 70 mL/min/1.73 m^2 (within 7 days prior to enrollment) OR - A serum creatinine based on age/sex as follows (within 7 days prior to enrollment): (mg/dL) - 1 month to < 6 months male: 0.4 female: 0.4 - 6 months to < 1 year male: 0.5 female: 0.5 - 1 to < 2 years male: 0.6 female: 0.6 - 2 to < 6 years male: 0.8 female: 0.8 - 6 to < 10 years male: 1 female: 1 - 10 to < 13 years male: 1.2 female: 1.2 - 13 to < 16 years: male: 1.5 female: 1.4 - >= 16 years male: 1.7 female: 1.4 - Total bilirubin =< 2 x upper limit of normal (ULN) for age (within 7 days prior to enrollment) - Unless due to Gilbert's disease, malignant involvement of liver or vanishing bile duct syndrome - Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) < 3 x upper limit of normal (ULN) (within 7 days prior to enrollment) - Unless due to Gilbert's disease, malignant involvement of liver or vanishing bile duct syndrome - Peripheral absolute neutrophil count (ANC) >= 750/mm^3 (within 7 days prior to enrollment) AND - Platelet count >= 75,000/mm^3 (within 7 days prior to enrollment) - Patients enrolling on the standard risk arms must be medically fit to receive protocol treatment and with no contraindications to protocol treatment - Eligibility criteria to participate in the pilot study of the AYA-Hears instrument (patient reported outcomes [PROs] of ototoxicity) Note: participants in group 1 will not receive AGCT1531 protocol-directed therapy; all other AYA-HEARS patients must be enrolled on the AGCT1531 SR2 arm in order to participate - >= 11 and < 25 years old at enrollment - Able to fluently speak and read English - Has received prior cisplatin- or carboplatin-based chemotherapy regimen for malignancy including diagnoses other than germ cell tumor - Followed for cancer or survivorship care at one of the following institutions: - Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center - Dana Farber/Harvard Cancer Center - Hospital for Sick Children - Children's Hospital of Eastern Ontario - Oregon Health and Science University - Seattle Children's Hospital - Yale University
Exclusion Criteria
- Patients with any diagnoses not listed including: - Stage I testicular cancer patients who have undergone primary RPLND (retroperitoneal lymph node dissection) - Pure ovarian or extragonadal dysgerminoma/seminoma - Pure mature teratoma - Pure immature teratoma with alpha-fetoprotein (AFP) >= 1000 ng/mL - "Poor risk" GCT (age >= 11 years old and COG stage IV ovarian, COG stage II- IV extragonadal, or IGCCC intermediate or poor risk testicular), or - Primary central nervous system (CNS) germ cell tumor - Germ cell tumor with somatic malignant transformation - Spermatocytic seminoma - Patients must have had no prior systemic therapy for the current cancer diagnosis - Patients must have had no prior radiation therapy with the exception of CNS irradiation of brain metastases; (this exception only applies to SR1 patients; any patients over age 11 with distant metastases to brain [stage IV disease] would be considered poor risk and therefore not eligible for this trial) - Patients with significant, pre-existing co-morbid respiratory disease that contraindicate the use of bleomycin are ineligible for the standard risk arms of the trial - Female patients who are pregnant since fetal toxicities and teratogenic effects have been noted for several of the study drugs; a pregnancy test is required for female patients of childbearing potential; (this criteria applies ONLY to patients who will receive chemotherapy [SR1 and SR2 patients]) - Lactating females who plan to breastfeed their infants; (this criteria applies ONLY to patients who will receive chemotherapy [SR1 and SR2 patients]) - Sexually active patients of reproductive potential who have not agreed to use an effective contraceptive method for the duration of their study participation; (this criteria applies ONLY to patients who will receive chemotherapy [SR1 and SR2 patients])
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Arm I (bleomycin, carboplatin, etoposide) |
Patients receive bleomycin IV over 10 minutes and carboplatin IV over 1 hour on day 1. Patients also receive etoposide IV over 1-2 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. |
|
|
Experimental Arm II (bleomycin, etoposide, cisplatin) |
Patients receive bleomycin IV over 10 minutes on day 1. Patients also receive etoposide IV over 1-2 hours and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. |
|
|
Experimental Arm III (bleomycin, etoposide, carboplatin) |
Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. |
|
|
Experimental Arm IV (bleomycin, etoposide, cisplatin) |
Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. |
|
|
Experimental Low-Risk (observation) |
Patients with low-risk stage I grade 2, 3 ovarian immature teratoma or stage I non-seminoma or seminoma MGCTs undergo observation and can transfer to standard risk arm when eligibility criteria are met. Patients with stage I seminoma testicular MGCT undergo observation, and those with residual/recurrent disease are treated at the discretion of their physician. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. |
|
Recruiting Locations
Children's Hospital of Alabama
Birmingham 4049979, Alabama 4829764 35233
Birmingham 4049979, Alabama 4829764 35233
USA Health Strada Patient Care Center
Mobile 4076598, Alabama 4829764 36604
Mobile 4076598, Alabama 4829764 36604
Contact:
Site Public Contact
800-388-8721
Site Public Contact
800-388-8721
Anchorage Associates in Radiation Medicine
Anchorage 5879400, Alaska 5879092 98508
Anchorage 5879400, Alaska 5879092 98508
Alaska Breast Care and Surgery LLC
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Alaska Oncology and Hematology LLC
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Alaska Women's Cancer Care
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Katmai Oncology Group
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Kingman Regional Medical Center
Kingman 5301067, Arizona 5551752 86401
Kingman 5301067, Arizona 5551752 86401
Banner Children's at Desert
Mesa 5304391, Arizona 5551752 85202
Mesa 5304391, Arizona 5551752 85202
Contact:
Site Public Contact
480-412-3100
Site Public Contact
480-412-3100
Phoenix Childrens Hospital
Phoenix 5308655, Arizona 5551752 85016
Phoenix 5308655, Arizona 5551752 85016
Contact:
Site Public Contact
602-546-0920
Site Public Contact
602-546-0920
Arkansas Children's Hospital
Little Rock 4119403, Arkansas 4099753 72202-3591
Little Rock 4119403, Arkansas 4099753 72202-3591
Contact:
Site Public Contact
501-364-7373
Site Public Contact
501-364-7373
CARTI Cancer Center
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
Kaiser Permanente-Anaheim
Anaheim 5323810, California 5332921 92806
Anaheim 5323810, California 5332921 92806
PCR Oncology
Arroyo Grande 5324802, California 5332921 93420
Arroyo Grande 5324802, California 5332921 93420
Kaiser Permanente-Bellflower
Bellflower 5327422, California 5332921 90706
Bellflower 5327422, California 5332921 90706
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank 5331835, California 5332921 91505
Burbank 5331835, California 5332921 91505
Kaiser Permanente Downey Medical Center
Downey 5343858, California 5332921 90242
Downey 5343858, California 5332921 90242
Contact:
Site Public Contact
626-564-3455
Site Public Contact
626-564-3455
Kaiser Permanente-Fontana
Fontana 5349755, California 5332921 92335
Fontana 5349755, California 5332921 92335
UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
La Jolla 5363943, California 5332921 92093
Loma Linda University Medical Center
Loma Linda 5367696, California 5332921 92354
Loma Linda 5367696, California 5332921 92354
Contact:
Site Public Contact
909-558-4050
Site Public Contact
909-558-4050
Miller Children's and Women's Hospital Long Beach
Long Beach 5367929, California 5332921 90806
Long Beach 5367929, California 5332921 90806
Contact:
Site Public Contact
562-933-5600
Site Public Contact
562-933-5600
Children's Hospital Los Angeles
Los Angeles 5368361, California 5332921 90027
Los Angeles 5368361, California 5332921 90027
Contact:
Site Public Contact
323-361-4110
Site Public Contact
323-361-4110
Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921 90027
Los Angeles 5368361, California 5332921 90027
Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965
Site Public Contact
310-423-8965
Mattel Children's Hospital UCLA
Los Angeles 5368361, California 5332921 90095
Los Angeles 5368361, California 5332921 90095
Contact:
Site Public Contact
310-825-6708
Site Public Contact
310-825-6708
Valley Children's Hospital
Madera 5369568, California 5332921 93636
Madera 5369568, California 5332921 93636
Providence Queen of The Valley
Napa 5376095, California 5332921 94558
Napa 5376095, California 5332921 94558
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
UCSF Benioff Children's Hospital Oakland
Oakland 5378538, California 5332921 94609
Oakland 5378538, California 5332921 94609
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Children's Hospital of Orange County
Orange 5379513, California 5332921 92868
Orange 5379513, California 5332921 92868
Lucile Packard Children's Hospital Stanford University
Palo Alto 5380748, California 5332921 94304
Palo Alto 5380748, California 5332921 94304
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089
Site Public Contact
916-734-3089
Kaiser Permanente-San Diego Mission
San Diego 5391811, California 5332921 92108
San Diego 5391811, California 5332921 92108
Rady Children's Hospital - San Diego
San Diego 5391811, California 5332921 92123
San Diego 5391811, California 5332921 92123
Contact:
Site Public Contact
858-966-5934
Site Public Contact
858-966-5934
Naval Medical Center -San Diego
San Diego 5391811, California 5332921 92134
San Diego 5391811, California 5332921 92134
Contact:
Site Public Contact
619-532-8712
Site Public Contact
619-532-8712
UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921 94158
San Francisco 5391959, California 5332921 94158
Providence Medical Foundation - Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
Providence Santa Rosa Memorial Hospital
Santa Rosa 5393287, California 5332921 95405
Santa Rosa 5393287, California 5332921 95405
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
Children's Hospital Colorado
Aurora 5412347, Colorado 5417618 80045
Aurora 5412347, Colorado 5417618 80045
Rocky Mountain Hospital for Children-Presbyterian Saint Luke's Medical Center
Denver 5419384, Colorado 5417618 80218
Denver 5419384, Colorado 5417618 80218
Connecticut Children's Medical Center
Hartford 4835797, Connecticut 4831725 06106
Hartford 4835797, Connecticut 4831725 06106
Contact:
Site Public Contact
860-545-9981
Site Public Contact
860-545-9981
Yale University
New Haven 4839366, Connecticut 4831725 06520
New Haven 4839366, Connecticut 4831725 06520
Alfred I duPont Hospital for Children
Wilmington 4145381, Delaware 4142224 19803
Wilmington 4145381, Delaware 4142224 19803
Children's National Medical Center
Washington D.C. 4140963, District of Columbia 4138106 20010
Washington D.C. 4140963, District of Columbia 4138106 20010
Broward Health Medical Center
Fort Lauderdale 4155966, Florida 4155751 33316
Fort Lauderdale 4155966, Florida 4155751 33316
Golisano Children's Hospital of Southwest Florida
Fort Myers 4155995, Florida 4155751 33908
Fort Myers 4155995, Florida 4155751 33908
University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751 32610
Gainesville 4156404, Florida 4155751 32610
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood 4158928, Florida 4155751 33021
Hollywood 4158928, Florida 4155751 33021
Nemours Children's Clinic-Jacksonville
Jacksonville 4160021, Florida 4155751 32207
Jacksonville 4160021, Florida 4155751 32207
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751 33136
Miami 4164138, Florida 4155751 33136
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
Nicklaus Children's Hospital
Miami 4164138, Florida 4155751 33155
Miami 4164138, Florida 4155751 33155
Contact:
Site Public Contact
888-624-2778
Site Public Contact
888-624-2778
Miami Cancer Institute
Miami 4164138, Florida 4155751 33176
Miami 4164138, Florida 4155751 33176
Contact:
Site Public Contact
786-596-2000
Site Public Contact
786-596-2000
AdventHealth Orlando
Orlando 4167147, Florida 4155751 32803
Orlando 4167147, Florida 4155751 32803
Arnold Palmer Hospital for Children
Orlando 4167147, Florida 4155751 32806
Orlando 4167147, Florida 4155751 32806
Nemours Children's Hospital
Orlando 4167147, Florida 4155751 32827
Orlando 4167147, Florida 4155751 32827
Nemours Children's Clinic - Pensacola
Pensacola 4168228, Florida 4155751 32504
Pensacola 4168228, Florida 4155751 32504
Johns Hopkins All Children's Hospital
St. Petersburg 4171563, Florida 4155751 33701
St. Petersburg 4171563, Florida 4155751 33701
Tampa General Hospital
Tampa 4174757, Florida 4155751 33606
Tampa 4174757, Florida 4155751 33606
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751 33607
Tampa 4174757, Florida 4155751 33607
Saint Mary's Medical Center
West Palm Beach 4177887, Florida 4155751 33407
West Palm Beach 4177887, Florida 4155751 33407
Contact:
Site Public Contact
561-822-4745
Site Public Contact
561-822-4745
Children's Healthcare of Atlanta - Arthur M Blank Hospital
Atlanta 4180439, Georgia 4197000 30329
Atlanta 4180439, Georgia 4197000 30329
Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Augusta 4180531, Georgia 4197000 30912
Atrium Health Navicent
Macon 4207400, Georgia 4197000 31201
Macon 4207400, Georgia 4197000 31201
Memorial Health University Medical Center
Savannah 4221552, Georgia 4197000 31404
Savannah 4221552, Georgia 4197000 31404
Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-522-4333
Site Public Contact
808-522-4333
Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797 96826
Honolulu 5856195, Hawaii 5855797 96826
Contact:
Site Public Contact
808-983-6090
Site Public Contact
808-983-6090
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Boise 5586437, Idaho 5596512 83712
Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Fruitland 5593708, Idaho 5596512 83619
Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Meridian 5600685, Idaho 5596512 83642
Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Nampa 5601933, Idaho 5596512 83687
Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Twin Falls 5610810, Idaho 5596512 83301
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
Memorial Hospital of Carbondale
Carbondale 4235193, Illinois 4896861 62902
Carbondale 4235193, Illinois 4896861 62902
SIH Cancer Institute
Carterville 4235311, Illinois 4896861 62918
Carterville 4235311, Illinois 4896861 62918
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Lurie Children's Hospital-Chicago
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60611
Contact:
Site Public Contact
773-880-4562
Site Public Contact
773-880-4562
University of Illinois
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046
Site Public Contact
312-355-3046
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
Chicago 4887398, Illinois 4896861 60637
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
NorthShore University HealthSystem-Evanston Hospital
Evanston 4891382, Illinois 4896861 60201
Evanston 4891382, Illinois 4896861 60201
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
NorthShore University HealthSystem-Glenbrook Hospital
Glenview 4893886, Illinois 4896861 60026
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
NorthShore University HealthSystem-Highland Park Hospital
Highland Park 4895876, Illinois 4896861 60035
Highland Park 4895876, Illinois 4896861 60035
Contact:
Site Public Contact
847-570-2109
Site Public Contact
847-570-2109
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Advocate Children's Hospital-Oak Lawn
Oak Lawn 4904365, Illinois 4896861 60453
Oak Lawn 4904365, Illinois 4896861 60453
Contact:
Site Public Contact
847-723-7570
Site Public Contact
847-723-7570
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Advocate Children's Hospital-Park Ridge
Park Ridge 4905367, Illinois 4896861 60068
Park Ridge 4905367, Illinois 4896861 60068
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
OSF Saint Francis Radiation Oncology at Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Peoria 4905687, Illinois 4896861 61636
Saint Jude Midwest Affiliate
Peoria 4905687, Illinois 4896861 61637
Peoria 4905687, Illinois 4896861 61637
Contact:
Site Public Contact
888-226-4343
Site Public Contact
888-226-4343
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Valley Radiation Oncology
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
815-664-4141
Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
Saint John's Hospital
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
Riley Hospital for Children
Indianapolis 4259418, Indiana 4921868 46202
Indianapolis 4259418, Indiana 4921868 46202
Contact:
Site Public Contact
800-248-1199
Site Public Contact
800-248-1199
Ascension Saint Vincent Indianapolis Hospital
Indianapolis 4259418, Indiana 4921868 46260
Indianapolis 4259418, Indiana 4921868 46260
Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Greater Regional Medical Center
Creston 4853078, Iowa 4862182 50801
Creston 4853078, Iowa 4862182 50801
Blank Children's Hospital
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182 52242
Iowa City 4862034, Iowa 4862182 52242
Contact:
Site Public Contact
800-237-1225
Site Public Contact
800-237-1225
Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182 50266
West Des Moines 4881346, Iowa 4862182 50266
Wesley Medical Center
Wichita 4281730, Kansas 4273857 67214
Wichita 4281730, Kansas 4273857 67214
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379
Site Public Contact
859-257-3379
Norton Children's Hospital
Louisville 4299276, Kentucky 6254925 40202
Louisville 4299276, Kentucky 6254925 40202
Children's Hospital New Orleans
New Orleans 4335045, Louisiana 4331987 70118
New Orleans 4335045, Louisiana 4331987 70118
Contact:
Site Public Contact
504-894-5377
Site Public Contact
504-894-5377
Ochsner Medical Center Jefferson
New Orleans 4335045, Louisiana 4331987 70121
New Orleans 4335045, Louisiana 4331987 70121
Eastern Maine Medical Center
Bangor 4957280, Maine 4971068 04401
Bangor 4957280, Maine 4971068 04401
Contact:
Site Public Contact
207-973-4274
Site Public Contact
207-973-4274
MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Portland 4975802, Maine 4971068 04102
Maine Children's Cancer Program
Scarborough 4977882, Maine 4971068 04074
Scarborough 4977882, Maine 4971068 04074
MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Scarborough 4977882, Maine 4971068 04074
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823
Site Public Contact
800-888-8823
Sinai Hospital of Baltimore
Baltimore 4347778, Maryland 4361885 21215
Baltimore 4347778, Maryland 4361885 21215
Contact:
Site Public Contact
410-601-9083
Site Public Contact
410-601-9083
Johns Hopkins University/Sidney Kimmel Cancer Center
Baltimore 4347778, Maryland 4361885 21287
Baltimore 4347778, Maryland 4361885 21287
Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885 20889-5600
Bethesda 4348599, Maryland 4361885 20889-5600
Contact:
Site Public Contact
301-319-2100
Site Public Contact
301-319-2100
Tufts Medical Center
Boston 4930956, Massachusetts 6254926 02111
Boston 4930956, Massachusetts 6254926 02111
Massachusetts General Hospital Cancer Center
Boston 4930956, Massachusetts 6254926 02114
Boston 4930956, Massachusetts 6254926 02114
Contact:
Site Public Contact
877-726-5130
Site Public Contact
877-726-5130
Dana-Farber Cancer Institute
Boston 4930956, Massachusetts 6254926 02215
Boston 4930956, Massachusetts 6254926 02215
Contact:
Site Public Contact
877-442-3324
Site Public Contact
877-442-3324
Baystate Medical Center
Springfield 4951788, Massachusetts 6254926 01199
Springfield 4951788, Massachusetts 6254926 01199
UMass Memorial Medical Center - University Campus
Worcester 4956184, Massachusetts 6254926 01655
Worcester 4956184, Massachusetts 6254926 01655
C S Mott Children's Hospital
Ann Arbor 4984247, Michigan 5001836 48109
Ann Arbor 4984247, Michigan 5001836 48109
Contact:
Site Public Contact
800-865-1125
Site Public Contact
800-865-1125
University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
Ann Arbor 4984247, Michigan 5001836 48109
Bronson Battle Creek
Battle Creek 4985153, Michigan 5001836 49017
Battle Creek 4985153, Michigan 5001836 49017
Children's Hospital of Michigan
Detroit 4990729, Michigan 5001836 48201
Detroit 4990729, Michigan 5001836 48201
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
Beacon Kalamazoo
Kalamazoo 4997787, Michigan 5001836 49048
Kalamazoo 4997787, Michigan 5001836 49048
Contact:
Site Public Contact
574-647-7370
Site Public Contact
574-647-7370
Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836 49444
Muskegon 5003132, Michigan 5001836 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836 49120
Niles 5003514, Michigan 5001836 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Corewell Health Reed City Hospital
Reed City 5006946, Michigan 5001836 49677
Reed City 5006946, Michigan 5001836 49677
Corewell Health Children's
Royal Oak 5007804, Michigan 5001836 48073
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Traverse City 5012495, Michigan 5001836 49684
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Wyoming 5015618, Michigan 5001836 49519
Children's Hospitals and Clinics of Minnesota - Minneapolis
Minneapolis 5037649, Minnesota 5037779 55404
Minneapolis 5037649, Minnesota 5037779 55404
University of Minnesota/Masonic Cancer Center
Minneapolis 5037649, Minnesota 5037779 55455
Minneapolis 5037649, Minnesota 5037779 55455
Contact:
Site Public Contact
612-624-2620
Site Public Contact
612-624-2620
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296 39216
Jackson 4431410, Mississippi 4436296 39216
Contact:
Site Public Contact
601-815-6700
Site Public Contact
601-815-6700
Mercy Cancer Center - Cape Girardeau
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
888-446-3729
Site Public Contact
888-446-3729
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
University of Missouri Children's Hospital
Columbia 4381982, Missouri 4398678 65212
Columbia 4381982, Missouri 4398678 65212
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Children's Mercy Hospitals and Clinics
Kansas City 4393217, Missouri 4398678 64108
Kansas City 4393217, Missouri 4398678 64108
Lake Regional Hospital
Osage Beach 4402040, Missouri 4398678 65065
Osage Beach 4402040, Missouri 4398678 65065
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
St Louis 4407066, Missouri 4398678 63110
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Saint Patrick Hospital - Community Hospital
Missoula 5666639, Montana 5667009 59802
Missoula 5666639, Montana 5667009 59802
Children's Hospital and Medical Center of Omaha
Omaha 5074472, Nebraska 5073708 68114
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-955-3949
Site Public Contact
402-955-3949
University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Omaha 5074472, Nebraska 5073708 68198
Carson Tahoe Regional Medical Center
Carson City 5501344, Nevada 5509151 89703
Carson City 5501344, Nevada 5509151 89703
Comprehensive Cancer Centers of Nevada - Henderson
Henderson 5505411, Nevada 5509151 89052
Henderson 5505411, Nevada 5509151 89052
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson 5505411, Nevada 5509151 89052
Henderson 5505411, Nevada 5509151 89052
OptumCare Cancer Care at Seven Hills
Henderson 5505411, Nevada 5509151 89052
Henderson 5505411, Nevada 5509151 89052
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson 5505411, Nevada 5509151 89074
Henderson 5505411, Nevada 5509151 89074
Las Vegas Urology - Green Valley
Henderson 5505411, Nevada 5509151 89074
Henderson 5505411, Nevada 5509151 89074
Las Vegas Urology - Pebble
Henderson 5505411, Nevada 5509151 89074
Henderson 5505411, Nevada 5509151 89074
Urology Specialists of Nevada - Green Valley
Henderson 5505411, Nevada 5509151 89074
Henderson 5505411, Nevada 5509151 89074
Las Vegas Urology - Pecos
Las Vegas 5506956, Nevada 5509151 89074
Las Vegas 5506956, Nevada 5509151 89074
OptumCare Cancer Care at Charleston
Las Vegas 5506956, Nevada 5509151 89102
Las Vegas 5506956, Nevada 5509151 89102
University Medical Center of Southern Nevada
Las Vegas 5506956, Nevada 5509151 89102
Las Vegas 5506956, Nevada 5509151 89102
Hope Cancer Care of Nevada
Las Vegas 5506956, Nevada 5509151 89103
Las Vegas 5506956, Nevada 5509151 89103
Radiation Oncology Centers of Nevada Central
Las Vegas 5506956, Nevada 5509151 89106
Las Vegas 5506956, Nevada 5509151 89106
Urology Specialists of Nevada - Central
Las Vegas 5506956, Nevada 5509151 89106
Las Vegas 5506956, Nevada 5509151 89106
Women's Cancer Center of Nevada
Las Vegas 5506956, Nevada 5509151 89106
Las Vegas 5506956, Nevada 5509151 89106
Contact:
Site Public Contact
702-851-4672
Site Public Contact
702-851-4672
Sunrise Hospital and Medical Center
Las Vegas 5506956, Nevada 5509151 89109
Las Vegas 5506956, Nevada 5509151 89109
Las Vegas Urology - Sunset
Las Vegas 5506956, Nevada 5509151 89113
Las Vegas 5506956, Nevada 5509151 89113
Urology Specialists of Nevada - Southwest
Las Vegas 5506956, Nevada 5509151 89113
Las Vegas 5506956, Nevada 5509151 89113
Radiation Oncology Centers of Nevada Southeast
Las Vegas 5506956, Nevada 5509151 89119
Las Vegas 5506956, Nevada 5509151 89119
Ann M Wierman MD LTD
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas 5506956, Nevada 5509151 89128
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas Urology - Cathedral Rock
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas Urology - Smoke Ranch
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas 5506956, Nevada 5509151 89128
OptumCare Cancer Care at MountainView
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas 5506956, Nevada 5509151 89128
Urology Specialists of Nevada - Northwest
Las Vegas 5506956, Nevada 5509151 89128
Las Vegas 5506956, Nevada 5509151 89128
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas 5506956, Nevada 5509151 89135
Las Vegas 5506956, Nevada 5509151 89135
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas 5506956, Nevada 5509151 89144
Las Vegas 5506956, Nevada 5509151 89144
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas 5506956, Nevada 5509151 89144
Las Vegas 5506956, Nevada 5509151 89144
Summerlin Hospital Medical Center
Las Vegas 5506956, Nevada 5509151 89144
Las Vegas 5506956, Nevada 5509151 89144
Comprehensive Cancer Centers of Nevada
Las Vegas 5506956, Nevada 5509151 89148
Las Vegas 5506956, Nevada 5509151 89148
OptumCare Cancer Care at Fort Apache
Las Vegas 5506956, Nevada 5509151 89148
Las Vegas 5506956, Nevada 5509151 89148
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas 5506956, Nevada 5509151 89169
Las Vegas 5506956, Nevada 5509151 89169
Hope Cancer Care of Nevada-Pahrump
Pahrump 5509851, Nevada 5509151 89048
Pahrump 5509851, Nevada 5509151 89048
Renown Regional Medical Center
Reno 5511077, Nevada 5509151 89502
Reno 5511077, Nevada 5509151 89502
Saint Mary's Regional Medical Center
Reno 5511077, Nevada 5509151 89503
Reno 5511077, Nevada 5509151 89503
Radiation Oncology Associates
Reno 5511077, Nevada 5509151 89509
Reno 5511077, Nevada 5509151 89509
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Lebanon 5088597, New Hampshire 5090174 03756
Hackensack University Medical Center
Hackensack 5098706, New Jersey 5101760 07601
Hackensack 5098706, New Jersey 5101760 07601
Contact:
Site Public Contact
551-996-2897
Site Public Contact
551-996-2897
Morristown Medical Center
Morristown 5101427, New Jersey 5101760 07960
Morristown 5101427, New Jersey 5101760 07960
Contact:
Site Public Contact
973-971-5900
Site Public Contact
973-971-5900
Jersey Shore Medical Center
Neptune City 5101687, New Jersey 5101760 07753
Neptune City 5101687, New Jersey 5101760 07753
Contact:
Site Public Contact
732-776-4240
Site Public Contact
732-776-4240
Saint Peter's University Hospital
New Brunswick 5101717, New Jersey 5101760 08901
New Brunswick 5101717, New Jersey 5101760 08901
Rutgers Cancer Institute of New Jersey-Robert Wood Johnson University Hospital
New Brunswick 5101717, New Jersey 5101760 08903
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-8675
Site Public Contact
732-235-8675
Newark Beth Israel Medical Center
Newark 5101798, New Jersey 5101760 07112
Newark 5101798, New Jersey 5101760 07112
Saint Joseph's Regional Medical Center
Paterson 5102466, New Jersey 5101760 07503
Paterson 5102466, New Jersey 5101760 07503
Presbyterian Hospital
Albuquerque 5454711, New Mexico 5481136 87106
Albuquerque 5454711, New Mexico 5481136 87106
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Albuquerque 5454711, New Mexico 5481136 87106
Albany Medical Center
Albany 5106834, New York 5128638 12208
Albany 5106834, New York 5128638 12208
Contact:
Site Public Contact
518-262-5513
Site Public Contact
518-262-5513
Maimonides Medical Center
Brooklyn 5110302, New York 5128638 11219
Brooklyn 5110302, New York 5128638 11219
Contact:
Site Public Contact
718-765-2500
Site Public Contact
718-765-2500
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Buffalo 5110629, New York 5128638 14263
NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638 11501
Mineola 5127134, New York 5128638 11501
The Steven and Alexandra Cohen Children's Medical Center of New York
New Hyde Park 5128514, New York 5128638 11040
New Hyde Park 5128514, New York 5128638 11040
Contact:
Site Public Contact
718-470-3460
Site Public Contact
718-470-3460
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638 10016
New York 5128581, New York 5128638 10016
Mount Sinai Hospital
New York 5128581, New York 5128638 10029
New York 5128581, New York 5128638 10029
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
New York 5128581, New York 5128638 10032
Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476
Site Public Contact
315-464-5476
Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
The Bronx 5110266, New York 5128638 10461
Montefiore Medical Center-Weiler Hospital
The Bronx 5110266, New York 5128638 10461
The Bronx 5110266, New York 5128638 10461
Children's Hospital at Montefiore
The Bronx 5110266, New York 5128638 10467
The Bronx 5110266, New York 5128638 10467
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
The Bronx 5110266, New York 5128638 10467
New York Medical College
Valhalla 5142090, New York 5128638 10595
Valhalla 5142090, New York 5128638 10595
Contact:
Site Public Contact
914-594-3794
Site Public Contact
914-594-3794
Westchester Medical Center
Valhalla 5142090, New York 5128638 10595
Valhalla 5142090, New York 5128638 10595
Mission Hospital
Asheville 4453066, North Carolina 4482348 28801
Asheville 4453066, North Carolina 4482348 28801
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Chapel Hill 4460162, North Carolina 4482348 27599
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348 28203
Charlotte 4460243, North Carolina 4482348 28203
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348 28204
Charlotte 4460243, North Carolina 4482348 28204
Southeastern Medical Oncology Center-Clinton
Clinton 4461101, North Carolina 4482348 28328
Clinton 4461101, North Carolina 4482348 28328
Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853
Site Public Contact
888-275-3853
Southeastern Medical Oncology Center-Goldsboro
Goldsboro 4468261, North Carolina 4482348 27534
Goldsboro 4468261, North Carolina 4482348 27534
East Carolina University
Greenville 4469160, North Carolina 4482348 27834
Greenville 4469160, North Carolina 4482348 27834
Southeastern Medical Oncology Center-Jacksonville
Jacksonville 4473083, North Carolina 4482348 28546
Jacksonville 4473083, North Carolina 4482348 28546
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348 27157
Winston-Salem 4499612, North Carolina 4482348 27157
Contact:
Site Public Contact
336-713-6771
Site Public Contact
336-713-6771
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Children's Hospital Medical Center of Akron
Akron 5145476, Ohio 5165418 44308
Akron 5145476, Ohio 5165418 44308
Contact:
Site Public Contact
330-543-3193
Site Public Contact
330-543-3193
OhioHealth O'Bleness Hospital
Athens 4505542, Ohio 5165418 45701
Athens 4505542, Ohio 5165418 45701
Strecker Cancer Center-Belpre
Belpre 4506187, Ohio 5165418 45714
Belpre 4506187, Ohio 5165418 45714
Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418 45601
Chillicothe 4828890, Ohio 5165418 45601
Cincinnati Children's Hospital Medical Center
Cincinnati 4508722, Ohio 5165418 45229
Cincinnati 4508722, Ohio 5165418 45229
Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Cleveland 5150529, Ohio 5165418 44106
Rainbow Babies and Childrens Hospital
Cleveland 5150529, Ohio 5165418 44106
Cleveland 5150529, Ohio 5165418 44106
Contact:
Site Public Contact
216-844-5437
Site Public Contact
216-844-5437
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418 44195
Cleveland 5150529, Ohio 5165418 44195
Nationwide Children's Hospital
Columbus 4509177, Ohio 5165418 43205
Columbus 4509177, Ohio 5165418 43205
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43210
Mount Carmel East Hospital
Columbus 4509177, Ohio 5165418 43213
Columbus 4509177, Ohio 5165418 43213
Columbus Oncology and Hematology Associates Inc
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Columbus 4509177, Ohio 5165418 43215
The Mark H Zangmeister Center
Columbus 4509177, Ohio 5165418 43219
Columbus 4509177, Ohio 5165418 43219
Mount Carmel Health Center West
Columbus 4509177, Ohio 5165418 43222
Columbus 4509177, Ohio 5165418 43222
Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
Columbus 4509177, Ohio 5165418 43228
Dayton Children's Hospital
Dayton 4509884, Ohio 5165418 45404
Dayton 4509884, Ohio 5165418 45404
Contact:
Site Public Contact
800-228-4055
Site Public Contact
800-228-4055
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Columbus Oncology and Hematology Associates
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Mount Carmel Grove City Hospital
Grove City 4513409, Ohio 5165418 43123
Grove City 4513409, Ohio 5165418 43123
Saint Rita's Medical Center
Lima 5160783, Ohio 5165418 45801
Lima 5160783, Ohio 5165418 45801
OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Mansfield 5161723, Ohio 5165418 44903
Marietta Memorial Hospital
Marietta 4517586, Ohio 5165418 45750
Marietta 4517586, Ohio 5165418 45750
OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
Marion 5161902, Ohio 5165418 43302
Memorial Hospital
Marysville 5162077, Ohio 5165418 43040
Marysville 5162077, Ohio 5165418 43040
Knox Community Hospital
Mount Vernon 5163799, Ohio 5165418 43050
Mount Vernon 5163799, Ohio 5165418 43050
Licking Memorial Hospital
Newark 5164466, Ohio 5165418 43055
Newark 5164466, Ohio 5165418 43055
Mercy Health - Perrysburg Hospital
Perrysburg 5166516, Ohio 5165418 43551
Perrysburg 5166516, Ohio 5165418 43551
OhioHealth Pickerington Methodist Hospital
Pickerington 4521209, Ohio 5165418 43147
Pickerington 4521209, Ohio 5165418 43147
Southern Ohio Medical Center
Portsmouth 4521816, Ohio 5165418 45662
Portsmouth 4521816, Ohio 5165418 45662
ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
Sylvania 5173572, Ohio 5165418 43560
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418 43606
Toledo 5174035, Ohio 5165418 43606
Mercy Health - Saint Vincent Hospital
Toledo 5174035, Ohio 5165418 43608
Toledo 5174035, Ohio 5165418 43608
Mercy Health - Saint Anne Hospital
Toledo 5174035, Ohio 5165418 43623
Toledo 5174035, Ohio 5165418 43623
Saint Ann's Hospital
Westerville 5176472, Ohio 5165418 43081
Westerville 5176472, Ohio 5165418 43081
OhioHealth Westerville Medical Campus/Westerville Cancer Center
Westerville 5176472, Ohio 5165418 43082
Westerville 5176472, Ohio 5165418 43082
Clinton Memorial Hospital/Foster J Boyd Regional Cancer Center
Wilmington 4528463, Ohio 5165418 45177
Wilmington 4528463, Ohio 5165418 45177
Genesis Healthcare System Cancer Care Center
Zanesville 4528923, Ohio 5165418 43701
Zanesville 4528923, Ohio 5165418 43701
Cancer Centers of Southwest Oklahoma Research
Lawton 4540737, Oklahoma 4544379 73505
Lawton 4540737, Oklahoma 4544379 73505
Contact:
Site Public Contact
877-231-4440
Site Public Contact
877-231-4440
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73104
Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
Bend 5713587, Oregon 5744337 97701
Clackamas Radiation Oncology Center
Clackamas 5719308, Oregon 5744337 97015
Clackamas 5719308, Oregon 5744337 97015
Bay Area Hospital
Coos Bay 5720495, Oregon 5744337 97420
Coos Bay 5720495, Oregon 5744337 97420
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Newberg 5742726, Oregon 5744337 97132
Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Oregon City 5744253, Oregon 5744337 97045
Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Portland 5746545, Oregon 5744337 97213
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Portland 5746545, Oregon 5744337 97225
Legacy Emanuel Children's Hospital
Portland 5746545, Oregon 5744337 97227
Portland 5746545, Oregon 5744337 97227
Contact:
Site Public Contact
503-413-2560
Site Public Contact
503-413-2560
Oregon Health and Science University
Portland 5746545, Oregon 5744337 97239
Portland 5746545, Oregon 5744337 97239
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927 18103
Allentown 5178127, Pennsylvania 6254927 18103
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Danville 5186327, Pennsylvania 6254927 17822
Penn State Children's Hospital
Hershey 5193342, Pennsylvania 6254927 17033
Hershey 5193342, Pennsylvania 6254927 17033
Contact:
Site Public Contact
717-531-6012
Site Public Contact
717-531-6012
Children's Hospital of Philadelphia
Philadelphia 4560349, Pennsylvania 6254927 19104
Philadelphia 4560349, Pennsylvania 6254927 19104
University of Pennsylvania/Abramson Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19104
Philadelphia 4560349, Pennsylvania 6254927 19104
Saint Christopher's Hospital for Children
Philadelphia 4560349, Pennsylvania 6254927 19134
Philadelphia 4560349, Pennsylvania 6254927 19134
Contact:
Site Public Contact
215-427-8991
Site Public Contact
215-427-8991
UPMC-Magee Womens Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15213
Pittsburgh 5206379, Pennsylvania 6254927 15213
Contact:
Site Public Contact
412-647-2811
Site Public Contact
412-647-2811
Children's Hospital of Pittsburgh of UPMC
Pittsburgh 5206379, Pennsylvania 6254927 15224
Pittsburgh 5206379, Pennsylvania 6254927 15224
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454
Site Public Contact
412-367-6454
Rhode Island Hospital
Providence 5224151, Rhode Island 5224323 02903
Providence 5224151, Rhode Island 5224323 02903
Contact:
Site Public Contact
401-444-1488
Site Public Contact
401-444-1488
Prisma Health Cancer Institute - Spartanburg
Boiling Springs 4571805, South Carolina 4597040 29316
Boiling Springs 4571805, South Carolina 4597040 29316
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Charleston 4574324, South Carolina 4597040 29425
Prisma Health Richland Hospital
Columbia 4575352, South Carolina 4597040 29203
Columbia 4575352, South Carolina 4597040 29203
Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040 29341
Gaffney 4579418, South Carolina 4597040 29341
Saint Francis Hospital
Greenville 4580543, South Carolina 4597040 29601
Greenville 4580543, South Carolina 4597040 29601
BI-LO Charities Children's Cancer Center
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Prisma Health Cancer Institute - Butternut
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Prisma Health Cancer Institute - Faris
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Saint Francis Cancer Center
Greenville 4580543, South Carolina 4597040 29607
Greenville 4580543, South Carolina 4597040 29607
Prisma Health Cancer Institute - Eastside
Greenville 4580543, South Carolina 4597040 29615
Greenville 4580543, South Carolina 4597040 29615
Prisma Health Cancer Institute - Greer
Greer 4580599, South Carolina 4597040 29650
Greer 4580599, South Carolina 4597040 29650
Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Greer 4580599, South Carolina 4597040 29651
Prisma Health Cancer Institute - Seneca
Seneca 4595346, South Carolina 4597040 29672
Seneca 4595346, South Carolina 4597040 29672
North Grove Medical Park
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6812
Site Public Contact
864-560-6812
Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg Medical Center - Mary Black Campus
Spartanburg 4597200, South Carolina 4597040 29307
Spartanburg 4597200, South Carolina 4597040 29307
Contact:
Site Public Contact
864-560-6812
Site Public Contact
864-560-6812
SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040 29379
Union 4599214, South Carolina 4597040 29379
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
T C Thompson Children's Hospital
Chattanooga 4612862, Tennessee 4662168 37403
Chattanooga 4612862, Tennessee 4662168 37403
Contact:
Site Public Contact
423-778-7289
Site Public Contact
423-778-7289
East Tennessee Childrens Hospital
Knoxville 4634946, Tennessee 4662168 37916
Knoxville 4634946, Tennessee 4662168 37916
Contact:
Site Public Contact
865-541-8266
Site Public Contact
865-541-8266
Saint Jude Children's Research Hospital
Memphis 4641239, Tennessee 4662168 38105
Memphis 4641239, Tennessee 4662168 38105
The Children's Hospital at TriStar Centennial
Nashville 4644585, Tennessee 4662168 37203
Nashville 4644585, Tennessee 4662168 37203
Contact:
Site Public Contact
615-342-1919
Site Public Contact
615-342-1919
Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168 37232
Nashville 4644585, Tennessee 4662168 37232
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
Texas Tech University Health Sciences Center-Amarillo
Amarillo 5516233, Texas 4736286 79106
Amarillo 5516233, Texas 4736286 79106
Contact:
Site Public Contact
806-354-5411
Site Public Contact
806-354-5411
Dell Children's Medical Center of Central Texas
Austin 4671654, Texas 4736286 78723
Austin 4671654, Texas 4736286 78723
Driscoll Children's Hospital
Corpus Christi 4683416, Texas 4736286 78411
Corpus Christi 4683416, Texas 4736286 78411
Medical City Dallas Hospital
Dallas 4684888, Texas 4736286 75230
Dallas 4684888, Texas 4736286 75230
Contact:
Site Public Contact
972-566-5588
Site Public Contact
972-566-5588
UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286 75390
Dallas 4684888, Texas 4736286 75390
El Paso Children's Hospital
El Paso 5520993, Texas 4736286 79905
El Paso 5520993, Texas 4736286 79905
Cook Children's Medical Center
Fort Worth 4691930, Texas 4736286 76104
Fort Worth 4691930, Texas 4736286 76104
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Covenant Children's Hospital
Lubbock 5525577, Texas 4736286 79410
Lubbock 5525577, Texas 4736286 79410
UMC Cancer Center / UMC Health System
Lubbock 5525577, Texas 4736286 79415
Lubbock 5525577, Texas 4736286 79415
Contact:
Site Public Contact
806-775-8590
Site Public Contact
806-775-8590
Children's Hospital of San Antonio
San Antonio 4726206, Texas 4736286 78207
San Antonio 4726206, Texas 4736286 78207
Methodist Children's Hospital of South Texas
San Antonio 4726206, Texas 4736286 78229
San Antonio 4726206, Texas 4736286 78229
University Hospital
San Antonio 4726206, Texas 4736286 78229
San Antonio 4726206, Texas 4736286 78229
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286 78229
San Antonio 4726206, Texas 4736286 78229
Scott and White Memorial Hospital
Temple 4735966, Texas 4736286 76508
Temple 4735966, Texas 4736286 76508
Contact:
Site Public Contact
254-724-5407
Site Public Contact
254-724-5407
Primary Children's Hospital
Salt Lake City 5780993, Utah 5549030 84113
Salt Lake City 5780993, Utah 5549030 84113
Contact:
Site Public Contact
801-585-5270
Site Public Contact
801-585-5270
University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283 05405
Burlington 5234372, Vermont 5242283 05405
University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928 22908
Charlottesville 4752031, Virginia 6254928 22908
Children's Hospital of The King's Daughters
Norfolk 4776222, Virginia 6254928 23507
Norfolk 4776222, Virginia 6254928 23507
Naval Medical Center - Portsmouth
Portsmouth 4779999, Virginia 6254928 23708-2197
Portsmouth 4779999, Virginia 6254928 23708-2197
Contact:
Site Public Contact
757-953-5939
Site Public Contact
757-953-5939
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928 23298
Richmond 4781708, Virginia 6254928 23298
Carilion Children's
Roanoke 4782167, Virginia 6254928 24014
Roanoke 4782167, Virginia 6254928 24014
Providence Regional Cancer System-Aberdeen
Aberdeen 5785243, Washington 5815135 98520
Aberdeen 5785243, Washington 5815135 98520
PeaceHealth Saint Joseph Medical Center
Bellingham 5786899, Washington 5815135 98225
Bellingham 5786899, Washington 5815135 98225
Contact:
Site Public Contact
360-788-8223
Site Public Contact
360-788-8223
Providence Regional Cancer System-Centralia
Centralia 5789683, Washington 5815135 98531
Centralia 5789683, Washington 5815135 98531
Swedish Cancer Institute-Edmonds
Edmonds 5793427, Washington 5815135 98026
Edmonds 5793427, Washington 5815135 98026
Providence Regional Cancer Partnership
Everett 5793933, Washington 5815135 98201
Everett 5793933, Washington 5815135 98201
Swedish Cancer Institute-Issaquah
Issaquah 5798487, Washington 5815135 98029
Issaquah 5798487, Washington 5815135 98029
Kadlec Clinic Hematology and Oncology
Kennewick 5799610, Washington 5815135 99336
Kennewick 5799610, Washington 5815135 99336
Providence Regional Cancer System-Lacey
Lacey 5800112, Washington 5815135 98503
Lacey 5800112, Washington 5815135 98503
PeaceHealth Saint John Medical Center
Longview 5801617, Washington 5815135 98632
Longview 5801617, Washington 5815135 98632
Seattle Children's Hospital
Seattle 5809844, Washington 5815135 98105
Seattle 5809844, Washington 5815135 98105
Contact:
Site Public Contact
866-987-2000
Site Public Contact
866-987-2000
Swedish Medical Center-Ballard Campus
Seattle 5809844, Washington 5815135 98107
Seattle 5809844, Washington 5815135 98107
Swedish Medical Center-Cherry Hill
Seattle 5809844, Washington 5815135 98122-5711
Seattle 5809844, Washington 5815135 98122-5711
Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135 98122
Seattle 5809844, Washington 5815135 98122
Providence Sacred Heart Medical Center and Children's Hospital
Spokane 5811696, Washington 5815135 99204
Spokane 5811696, Washington 5815135 99204
Mary Bridge Children's Hospital and Health Center
Tacoma 5812944, Washington 5815135 98405
Tacoma 5812944, Washington 5815135 98405
Madigan Army Medical Center
Tacoma 5812944, Washington 5815135 98431
Tacoma 5812944, Washington 5815135 98431
Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Walla Walla 5814916, Washington 5815135 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima 5816605, Washington 5815135 98902
Yakima 5816605, Washington 5815135 98902
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850 25304
Charleston 4801859, West Virginia 4826850 25304
Contact:
Site Public Contact
304-388-9944
Site Public Contact
304-388-9944
Edwards Comprehensive Cancer Center
Huntington 4809537, West Virginia 4826850 25701
Huntington 4809537, West Virginia 4826850 25701
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Morgantown 4815352, West Virginia 4826850 26506
Green Bay Oncology at Saint Vincent Hospital
Green Bay 5254962, Wisconsin 5279468 54301-3526
Green Bay 5254962, Wisconsin 5279468 54301-3526
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay 5254962, Wisconsin 5279468 54303
Green Bay 5254962, Wisconsin 5279468 54303
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Madison 5261457, Wisconsin 5279468 53792
Children's Hospital of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Milwaukee 5263045, Wisconsin 5279468 53226
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls 5265522, Wisconsin 5279468 54154
Oconto Falls 5265522, Wisconsin 5279468 54154
HSHS Saint Nicholas Hospital
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
More Details
- NCT ID
- NCT03067181
- Status
- Recruiting
- Sponsor
- Children's Oncology Group
Detailed Description
PRIMARY OBJECTIVES: I. To evaluate whether a strategy of complete surgical resection followed by surveillance can maintain an overall survival rate of at least 95.7% at two years for pediatric, adolescent and adult patients with stage I (low risk) malignant germ cell tumors (Stratum 2), and at least 88% for patients with all stage/grade ovarian pure immature teratoma (Stratum 1). II. To compare the event-free survival of a carboplatin versus (vs.) cisplatin-based regimen in the treatment of pediatric, adolescent and young adult patients with standard risk non-seminomatous germ cell tumors. IIa. To compare the event free survival (EFS) of a carboplatin-based regimen (carboplatin [C] etoposide [E] bleomycin [b]) vs. a cisplatin-based regimen (cisplatin [P]Eb) in children (less than 11 years in age) with standard risk germ cell tumors (GCT). IIb. To compare the EFS of a carboplatin-based regimen (BEC) vs. a cisplatin-based regimen (BEP) in adolescents and young adults (ages 11 - < 25 years) with standard risk GCT. SECONDARY OBJECTIVES: I. To compare the incidence of ototoxicity in children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin-based chemotherapy. II. To refine and validate a novel patient-reported measure of hearing outcomes for children, adolescents and young adults with standard risk germ cell tumors. III. To determine whether radiomic measures of body composition at diagnosis, end of therapy, and one year after end of therapy is better correlated with adverse events compared to body surface area in patients receiving chemotherapy for germ cell tumors. EXPLORATORY OBJECTIVES: I. To prospectively determine the correlation of tumor marker decline (alpha-fetoprotein [FP] and beta-human chorionic gonadotropin [HCG]) with clinical outcome in low and standard risk germ cell tumor patients. II. To compare self-reported peripheral neuropathy and other patient-reported outcomes between children, adolescents and young adults with standard risk germ cell tumors treated with carboplatin-based chemotherapy as compared to cisplatin-based chemotherapy. III. Assess the relationship between hearing loss as measured by audiometry with the effects of tinnitus as assessed on the Adolescent and Young Adult Hearing Screening (AYA-HEARS) instrument. IV. To evaluate the prognostic significance of serum micro ribonucleic acid (miRNA)s in stage I testicular cancer (seminoma and non-seminoma) patients by collecting clinical data and serum specimens for future analysis. V. To compare differences in the proportion of patients with residual mass(es) ≥ 1 cm at the completion of chemotherapy among patients randomized to the cisplatin and carboplatin-containing arms and to compare the proportion undergoing post-chemotherapy surgery for residual mass(es), and the proportion of resected masses with viable malignancy, teratoma, or necrosis. OUTLINE: Patients with low-risk stage I grade 2, 3 ovarian immature teratoma or stage I non-seminoma malignant germ cell tumors (MGCT)s undergo observation and can transfer to standard risk arm at time of recurrence if eligibility criteria are met. Patients with stage I seminoma testicular MGCT undergo observation, and those with residual/recurrent disease are treated at the discretion of their physician. Patients undergo computed tomography (CT), magnetic resonance imaging (MRI), and/or chest x-ray as well as blood sample collection throughout the trial to monitor for response and recurrence. Patients may also undergo a tumor biopsy throughout the trial. Patients with standard risk 1 are randomized into 1 of 2 arms. ARM I (CEb): Patients receive bleomycin intravenously (IV) over 10 minutes and carboplatin IV over 1 hour on day 1. Patients also receive etoposide IV over 1-2 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. ARM II (PEb): Patients receive bleomycin IV over 10 minutes on day 1. Patients also receive etoposide IV over 1-2 hours and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 4 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. Patients with standard risk 2 are randomized into 1 of 2 arms. ARM III (BEC): Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and carboplatin IV over 1 hour on day 1. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. ARM IV (BEP): Patients receive bleomycin IV over 10 minutes on days 1, 8, and 15, etoposide IV over 1-2 hours on days 1-5, and cisplatin IV over 1-3 hours on days 1-5. Treatment repeats every 21 days for up to 3 cycles in the absence of disease progression or unacceptable toxicity. Patients undergo CT, MRI, and/or chest x-ray as well as blood sample collection throughout the trial. Patients may also undergo a tumor biopsy throughout the trial. Patients undergo a pulmonary function test on study. After completion of study treatment, patients are followed up every 2 months for 12 months, every 3-6 months to 24 months, every 6 months for years 3-5, and then annually for up to 10 years.