Duloxetine to Prevent Oxaliplatin-Induced Peripheral Neuropathy in Patients With Stage II-III Colorectal Cancer
Purpose
This phase II/III trial studies the best dose of duloxetine and how well it works in preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent peripheral neuropathy.
Conditions
- Stage II Colorectal Cancer AJCC v8
- Stage III Colorectal Cancer AJCC v8
Eligibility
- Eligible Ages
- Over 25 Years
- Eligible Genders
- All
- Accepts Healthy Volunteers
- No
Criteria
- Stage II-III colorectal cancer patients scheduled to receive oxaliplatin 510 mg/m^2
(cumulative dose) over 12 weeks as a component of adjuvant leucovorin calcium (calcium
folinate), 5-fluorouracil and oxaliplatin (FOLFOX) treatment, in which patients are
scheduled to receive oxaliplatin 85 mg/m^2 every 2 weeks for 12 weeks (i.e., 6
cycles), or adjuvant capecitabine and oxaliplatin (CAPOX) treatment, in which patients
are scheduled to receive oxaliplatin 135 mg/m^2 every 3 weeks for 12 weeks (i.e., 4
cycles)
- No prior neurotoxic chemotherapy
- No pre-existing clinical or pre-clinical peripheral neuropathy from any cause.
- No history of seizure disorder,
- No history of narrow-angle glaucoma.
- No symptoms of or history of schizophrenia, bipolar disease, suicidal thoughts and/or
a major depression.
- No serious eating disorder such as bulimia or anorexia.
- No known diagnosis of ethanol (ETOH) addiction/dependence within the past 10 years.
- Concomitant medications:
- No concomitant use of other adjuvant pharmacologic interventions (e.g.,
gabapentin, pregabalin, venlafaxine) with known or hypothesized efficacy for
peripheral neuropathy. Must be discontinued at least 7 days prior to start of
protocol treatment
- No anticipated or concurrent use of any antidepressant or serotonin-altering
agent known to interact with duloxetine, due to concern regarding cumulative
toxicity and potential drug interactions.
- Use of a monoamine oxidase inhibitor (MAOI) or other antidepressants must be
discontinued at least 14 days prior to start of protocol treatment.
- No concomitant treatment with strong CYP1A2 and CYP2D6 inhibitors.
- Chronic concomitant treatment with drugs that are extensively metabolized by
CYP2D6 and that have a narrow therapeutic index, including certain
antidepressants, phenothiazines, and Type 1C antiarrhythmics should be approached
with caution. Concomitant administration of duloxetine and thioridazine should be
avoided.
- No use of warfarin or heparin products.
- Not pregnant and not nursing, because this study involves an investigational agent
whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn
are unknown. Therefore, for women of childbearing potential, a negative pregnancy test
done =< 7 days prior to registration is required
- Eastern Cooperative Oncology Group (ECOG) performance status 0-2
- In order to complete the mandatory patient-completed measure, patients must be able to
speak and read English
- Calculated creatinine clearance > 30 mL/min
- Aspartate aminotransferases (AST)/serum glutamic-oxaloacetic transaminase (SGOT) =< 3
x upper limit of normal (ULN)
Study Design
- Phase
- Phase 2/Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Sequential Assignment
- Primary Purpose
- Supportive Care
- Masking
- Double (Participant, Investigator)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Phase II, Arm I (duloxetine hydrochloride, placebo) |
Patients in Phase II receive duloxetine hydrochloride 30 mg (1 duloxetine capsule) orally (PO) once daily (QD) during week 1, duloxetine hydrochloride 30 mg (1 duloxetine capsule) PO QD and placebo (1 placebo capsule) PO QD during weeks 2-16, followed by duloxetine hydrochloride 30 mg (1 duloxetine capsule) PO QD during week 17 in the absence of unacceptable toxicity. |
|
|
Experimental Phase II, Arm II (duloxetine hydrochloride) |
Patients in Phase II receive duloxetine hydrochloride 30 mg (1 duloxetine capsule) orally (PO) once daily (QD) during week 1, duloxetine hydrochloride 60 mg (2 duloxetine capsules) PO QD during weeks 2-16, followed by duloxetine hydrochloride 30 mg (1 duloxetine capsule) PO QD during week 17 in the absence of unacceptable toxicity. |
|
|
Placebo Comparator Phase II, Arm III (placebo) |
Patients in Phase II receive placebo (1 placebo capsule) orally (PO) once daily (QD) during week 1, placebo (2 placebo capsules) PO QD weeks 2-16, followed by placebo (1 placebo capsule) PO QD during week 17 in the absence of unacceptable toxicity. |
|
|
Experimental Phase III, Arm I (duloxetine hydrochloride) |
Patients in Phase III receive most promising dose of duloxetine hydrochloride from Phase II PO QD in the absence of unacceptable toxicity. |
|
|
Placebo Comparator Phase III, Arm II (placebo) |
Patients in Phase III receive placebo PO QD in the absence of unacceptable toxicity. |
|
Recruiting Locations
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
Birmingham, Alabama 35233
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
Mobile, Alabama 36688
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
Anchorage, Alaska 98508
Anchorage Radiation Therapy Center
Anchorage, Alaska 99504
Anchorage, Alaska 99504
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Alaska Women's Cancer Care
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Anchorage Oncology Centre
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Katmai Oncology Group
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Providence Alaska Medical Center
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Kingman Regional Medical Center
Kingman, Arizona 86401
Kingman, Arizona 86401
Cancer Center at Saint Joseph's
Phoenix, Arizona 85004
Phoenix, Arizona 85004
Mercy Hospital Fort Smith
Fort Smith, Arkansas 72903
Fort Smith, Arkansas 72903
Contact:
Site Public Contact
800-378-9373
Site Public Contact
800-378-9373
CARTI Cancer Center
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
John L McClellan Memorial Veterans Hospital
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande, California 93420
Arroyo Grande, California 93420
PCR Oncology
Arroyo Grande, California 93420
Arroyo Grande, California 93420
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
Burbank, California 91505
Mercy Cancer Center �� Carmichael
Carmichael, California 95608
Carmichael, California 95608
Mercy San Juan Medical Center
Carmichael, California 95608
Carmichael, California 95608
City of Hope Comprehensive Cancer Center
Duarte, California 91010
Duarte, California 91010
Epic Care-Dublin
Dublin, California 94568
Dublin, California 94568
Contact:
Site Public Contact
925-875-1677
Site Public Contact
925-875-1677
Mercy Cancer Center - Elk Grove
Elk Grove, California 95758
Elk Grove, California 95758
Bay Area Breast Surgeons Inc
Emeryville, California 94608
Emeryville, California 94608
Contact:
Site Public Contact
510-835-9900
Site Public Contact
510-835-9900
Epic Care Partners in Cancer Care
Emeryville, California 94608
Emeryville, California 94608
Contact:
Site Public Contact
510-629-6682
Site Public Contact
510-629-6682
Washington Hospital
Fremont, California 94538
Fremont, California 94538
Contact:
Site Public Contact
510-745-6433
Site Public Contact
510-745-6433
City of Hope Antelope Valley
Lancaster, California 93534
Lancaster, California 93534
Contra Costa Regional Medical Center
Martinez, California 94553-3156
Martinez, California 94553-3156
Contact:
Site Public Contact
925-957-5400
Site Public Contact
925-957-5400
Mercy UC Davis Cancer Center
Merced, California 95340
Merced, California 95340
Providence Queen of The Valley
Napa, California 94558
Napa, California 94558
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
Bay Area Tumor Institute
Oakland, California 94609
Oakland, California 94609
Eisenhower Medical Center
Rancho Mirage, California 92270
Rancho Mirage, California 92270
Contact:
Site Public Contact
760-834-3798
Site Public Contact
760-834-3798
Mercy Cancer Center - Rocklin
Rocklin, California 95765
Rocklin, California 95765
Mercy Cancer Center - Sacramento
Sacramento, California 95816
Sacramento, California 95816
Zuckerberg San Francisco General Hospital
San Francisco, California 94110
San Francisco, California 94110
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo, California 93401
San Luis Obispo, California 93401
Mission Hope Medical Oncology - Santa Maria
Santa Maria, California 93444
Santa Maria, California 93444
Providence Medical Foundation - Santa Rosa
Santa Rosa, California 95403
Santa Rosa, California 95403
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
City of Hope South Pasadena
South Pasadena, California 91030
South Pasadena, California 91030
City of Hope Upland
Upland, California 91786
Upland, California 91786
Epic Care Cyberknife Center
Walnut Creek, California 94597
Walnut Creek, California 94597
Woodland Memorial Hospital
Woodland, California 95695
Woodland, California 95695
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Colorado Springs, Colorado 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs, Colorado 80907
Colorado Springs, Colorado 80907
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
Colorado Springs, Colorado 80909
Contact:
Site Public Contact
719-365-2406
Site Public Contact
719-365-2406
Memorial Hospital North
Colorado Springs, Colorado 80920
Colorado Springs, Colorado 80920
Contact:
Site Public Contact
719-364-6700
Site Public Contact
719-364-6700
Saint Francis Cancer Center
Colorado Springs, Colorado 80923
Colorado Springs, Colorado 80923
Kaiser Permanente-Franklin
Denver, Colorado 80205
Denver, Colorado 80205
National Jewish Health-Main Campus
Denver, Colorado 80206
Denver, Colorado 80206
SCL Health Saint Joseph Hospital
Denver, Colorado 80218
Denver, Colorado 80218
Mercy Medical Center
Durango, Colorado 81301
Durango, Colorado 81301
Southwest Oncology PC
Durango, Colorado 81301
Durango, Colorado 81301
Poudre Valley Hospital
Fort Collins, Colorado 80524
Fort Collins, Colorado 80524
Contact:
Site Public Contact
970-297-6150
Site Public Contact
970-297-6150
Cancer Care and Hematology-Fort Collins
Fort Collins, Colorado 80528
Fort Collins, Colorado 80528
National Jewish Health-Western Hematology Oncology
Golden, Colorado 80401
Golden, Colorado 80401
SCL Health Cancer Centers of Colorado - Lutheran Medical Center
Golden, Colorado 80401
Golden, Colorado 80401
Saint Mary's Hospital and Regional Medical Center
Grand Junction, Colorado 81501
Grand Junction, Colorado 81501
North Colorado Medical Center
Greeley, Colorado 80631
Greeley, Colorado 80631
UCHealth Greeley Hospital
Greeley, Colorado 80631
Greeley, Colorado 80631
Kaiser Permanente-Rock Creek
Lafayette, Colorado 80026
Lafayette, Colorado 80026
Saint Anthony Hospital
Lakewood, Colorado 80228
Lakewood, Colorado 80228
Kaiser Permanente-Lone Tree
Lone Tree, Colorado 80124
Lone Tree, Colorado 80124
Longmont United Hospital
Longmont, Colorado 80501
Longmont, Colorado 80501
Medical Center of the Rockies
Loveland, Colorado 80538
Loveland, Colorado 80538
Contact:
Site Public Contact
970-203-7083
Site Public Contact
970-203-7083
McKee Medical Center
Loveland, Colorado 80539
Loveland, Colorado 80539
Saint Mary Corwin Medical Center
Pueblo, Colorado 81004
Pueblo, Colorado 81004
National Jewish Health-Northern Hematology Oncology
Thornton, Colorado 80260
Thornton, Colorado 80260
SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
Wheat Ridge, Colorado 80033
Hartford Hospital
Hartford, Connecticut 06102
Hartford, Connecticut 06102
Contact:
Site Public Contact
860-545-5363
Site Public Contact
860-545-5363
Midstate Medical Center
Meriden, Connecticut 06451
Meriden, Connecticut 06451
Contact:
Site Public Contact
866-662-5678
Site Public Contact
866-662-5678
The Hospital of Central Connecticut
New Britain, Connecticut 06050
New Britain, Connecticut 06050
Contact:
Site Public Contact
860-224-5660
Site Public Contact
860-224-5660
Stamford Hospital/Bennett Cancer Center
Stamford, Connecticut 06904
Stamford, Connecticut 06904
Contact:
Site Public Contact
203-323-8944
Site Public Contact
203-323-8944
Beebe South Coastal Health Campus
Frankford, Delaware 19945
Frankford, Delaware 19945
Beebe Medical Center
Lewes, Delaware 19958
Lewes, Delaware 19958
Helen F Graham Cancer Center
Newark, Delaware 19713
Newark, Delaware 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Newark, Delaware 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
Newark, Delaware 19718
Beebe Health Campus
Rehoboth Beach, Delaware 19971
Rehoboth Beach, Delaware 19971
Christiana Care Health System-Wilmington Hospital
Wilmington, Delaware 19801
Wilmington, Delaware 19801
Kaiser Permanente-Capitol Hill Medical Center
Washington, District of Columbia 20002
Washington, District of Columbia 20002
Contact:
Site Public Contact
301-548-5743
Site Public Contact
301-548-5743
MedStar Washington Hospital Center
Washington, District of Columbia 20010
Washington, District of Columbia 20010
Contact:
Site Public Contact
202-877-8839
Site Public Contact
202-877-8839
AdventHealth Altamonte
Altamonte Springs, Florida 32701
Altamonte Springs, Florida 32701
Contact:
Site Public Contact
407-303-2200
Site Public Contact
407-303-2200
AdventHealth Celebration
Celebration, Florida 34747
Celebration, Florida 34747
Contact:
Site Public Contact
407-303-4120
Site Public Contact
407-303-4120
Morton Plant Hospital
Clearwater, Florida 33756
Clearwater, Florida 33756
Contact:
Site Public Contact
855-314-8646
Site Public Contact
855-314-8646
Holy Cross Hospital
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
Contact:
Site Public Contact
954-267-7748
Site Public Contact
954-267-7748
AdventHealth Kissimmee
Kissimmee, Florida 34744
Kissimmee, Florida 34744
Contact:
Site Public Contact
407-846-4343
Site Public Contact
407-846-4343
AdventHealth Medical Group Urology at Orlando
Orlando, Florida 32803
Orlando, Florida 32803
Contact:
Site Public Contact
407-897-3499
Site Public Contact
407-897-3499
AdventHealth Orlando
Orlando, Florida 32803
Orlando, Florida 32803
AdventHealth East Orlando
Orlando, Florida 32822
Orlando, Florida 32822
Contact:
Site Public Contact
407-303-8110
Site Public Contact
407-303-8110
South Florida Baptist Hospital
Plant City, Florida 33563
Plant City, Florida 33563
Mease Countryside Hospital
Safety Harbor, Florida 34695
Safety Harbor, Florida 34695
Saint Anthony's Hospital Cancer Care Center
Saint Petersburg, Florida 33705
Saint Petersburg, Florida 33705
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa, Florida 33607
Tampa, Florida 33607
AdventHealth Winter Park
Winter Park, Florida 32792
Winter Park, Florida 32792
Contact:
Site Public Contact
407-646-7000
Site Public Contact
407-646-7000
Phoebe Putney Memorial Hospital
Albany, Georgia 31701
Albany, Georgia 31701
Augusta Oncology Associates PC-D'Antignac
Augusta, Georgia 30901
Augusta, Georgia 30901
Contact:
Site Public Contact
706-821-2944
Site Public Contact
706-821-2944
Augusta Oncology Associates PC-Wheeler
Augusta, Georgia 30909
Augusta, Georgia 30909
Contact:
Site Public Contact
706-736-1830
Site Public Contact
706-736-1830
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Boise, Idaho 83706
Saint Luke's Cancer Institute - Boise
Boise, Idaho 83712
Boise, Idaho 83712
Saint Alphonsus Cancer Care Center-Caldwell
Caldwell, Idaho 83605
Caldwell, Idaho 83605
Kootenai Health - Coeur d'Alene
Coeur d'Alene, Idaho 83814
Coeur d'Alene, Idaho 83814
Walter Knox Memorial Hospital
Emmett, Idaho 83617
Emmett, Idaho 83617
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho 83619
Fruitland, Idaho 83619
Idaho Urologic Institute-Meridian
Meridian, Idaho 83642
Meridian, Idaho 83642
Saint Luke's Cancer Institute - Meridian
Meridian, Idaho 83642
Meridian, Idaho 83642
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho 83686
Nampa, Idaho 83686
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
Nampa, Idaho 83687
Kootenai Clinic Cancer Services - Post Falls
Post Falls, Idaho 83854
Post Falls, Idaho 83854
Kootenai Cancer Clinic
Sandpoint, Idaho 83864
Sandpoint, Idaho 83864
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho 83301
Twin Falls, Idaho 83301
Saint Anthony's Health
Alton, Illinois 62002
Alton, Illinois 62002
Contact:
Site Public Contact
618-463-5623
Site Public Contact
618-463-5623
Rush - Copley Medical Center
Aurora, Illinois 60504
Aurora, Illinois 60504
Illinois CancerCare-Bloomington
Bloomington, Illinois 61704
Bloomington, Illinois 61704
Loyola Center for Health at Burr Ridge
Burr Ridge, Illinois 60527
Burr Ridge, Illinois 60527
Contact:
Site Public Contact
708-216-9000
Site Public Contact
708-216-9000
Illinois CancerCare-Canton
Canton, Illinois 61520
Canton, Illinois 61520
Memorial Hospital of Carbondale
Carbondale, Illinois 62902
Carbondale, Illinois 62902
SIH Cancer Institute
Carterville, Illinois 62918
Carterville, Illinois 62918
Illinois CancerCare-Carthage
Carthage, Illinois 62321
Carthage, Illinois 62321
Centralia Oncology Clinic
Centralia, Illinois 62801
Centralia, Illinois 62801
Saint Mary's Hospital
Centralia, Illinois 62801
Centralia, Illinois 62801
Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
Jesse Brown Veterans Affairs Medical Center
Chicago, Illinois 60612
Chicago, Illinois 60612
Contact:
Site Public Contact
312-469-4304
Site Public Contact
312-469-4304
John H Stroger Jr Hospital of Cook County
Chicago, Illinois 60612
Chicago, Illinois 60612
Contact:
Site Public Contact
312-864-5204
Site Public Contact
312-864-5204
Carle at The Riverfront
Danville, Illinois 61832
Danville, Illinois 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Decatur, Illinois 62526
Decatur Memorial Hospital
Decatur, Illinois 62526
Decatur, Illinois 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
DeKalb, Illinois 60115
Illinois CancerCare-Dixon
Dixon, Illinois 61021
Dixon, Illinois 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Carle Physician Group-Effingham
Effingham, Illinois 62401
Effingham, Illinois 62401
Crossroads Cancer Center
Effingham, Illinois 62401
Effingham, Illinois 62401
Illinois CancerCare-Eureka
Eureka, Illinois 61530
Eureka, Illinois 61530
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Western Illinois Cancer Treatment Center
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Contact:
Site Public Contact
309-344-2831
Site Public Contact
309-344-2831
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Geneva, Illinois 60134
Ingalls Memorial Hospital
Harvey, Illinois 60426
Harvey, Illinois 60426
Loyola Medicine Homer Glen
Homer Glen, Illinois 60491
Homer Glen, Illinois 60491
Contact:
Site Public Contact
708-216-9000
Site Public Contact
708-216-9000
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Kewanee, Illinois 61443
Illinois CancerCare-Macomb
Macomb, Illinois 61455
Macomb, Illinois 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Mattoon, Illinois 61938
Loyola University Medical Center
Maywood, Illinois 60153
Maywood, Illinois 60153
Contact:
Site Public Contact
708-226-4357
Site Public Contact
708-226-4357
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park, Illinois 60160
Melrose Park, Illinois 60160
Contact:
Site Public Contact
708-450-4554
Site Public Contact
708-450-4554
Trinity Medical Center
Moline, Illinois 61265
Moline, Illinois 61265
Contact:
Site Public Contact
309-779-2000
Site Public Contact
309-779-2000
Good Samaritan Regional Health Center
Mount Vernon, Illinois 62864
Mount Vernon, Illinois 62864
Contact:
Site Public Contact
618-242-4600
Site Public Contact
618-242-4600
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Ottawa, Illinois 61350
Illinois CancerCare-Pekin
Pekin, Illinois 61554
Pekin, Illinois 61554
Illinois CancerCare-Peoria
Peoria, Illinois 61615
Peoria, Illinois 61615
Methodist Medical Center of Illinois
Peoria, Illinois 61636
Peoria, Illinois 61636
Illinois CancerCare-Peru
Peru, Illinois 61354
Peru, Illinois 61354
Valley Radiation Oncology
Peru, Illinois 61354
Peru, Illinois 61354
Contact:
Site Public Contact
815-664-4141
Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton, Illinois 61356
Princeton, Illinois 61356
West Suburban Medical Center
River Forest, Illinois 60305
River Forest, Illinois 60305
OSF Saint Anthony Medical Center
Rockford, Illinois 61108
Rockford, Illinois 61108
Contact:
Site Public Contact
815-227-2633
Site Public Contact
815-227-2633
Memorial Hospital East
Shiloh, Illinois 62269
Shiloh, Illinois 62269
Southern Illinois University School of Medicine
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
Springfield, Illinois 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Memorial Medical Center
Springfield, Illinois 62781
Springfield, Illinois 62781
Carle Cancer Center
Urbana, Illinois 61801
Urbana, Illinois 61801
The Carle Foundation Hospital
Urbana, Illinois 61801
Urbana, Illinois 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Warrenville, Illinois 60555
Illinois CancerCare - Washington
Washington, Illinois 61571
Washington, Illinois 61571
Rush-Copley Healthcare Center
Yorkville, Illinois 60560
Yorkville, Illinois 60560
Northwest Cancer Center - Main Campus
Crown Point, Indiana 46307
Crown Point, Indiana 46307
Contact:
Site Public Contact
219-310-2550
Site Public Contact
219-310-2550
Northwest Oncology LLC
Dyer, Indiana 46311
Dyer, Indiana 46311
Contact:
Site Public Contact
219-924-8178
Site Public Contact
219-924-8178
Northwest Cancer Center - Hobart
Hobart, Indiana 46342
Hobart, Indiana 46342
Contact:
Site Public Contact
219-947-1795
Site Public Contact
219-947-1795
Saint Mary Medical Center
Hobart, Indiana 46342
Hobart, Indiana 46342
Saint Catherine Hospital
Indianapolis, Indiana 46312
Indianapolis, Indiana 46312
The Community Hospital
Munster, Indiana 46321
Munster, Indiana 46321
Contact:
Site Public Contact
219-836-3349
Site Public Contact
219-836-3349
Women's Diagnostic Center - Munster
Munster, Indiana 46321
Munster, Indiana 46321
Reid Health
Richmond, Indiana 47374
Richmond, Indiana 47374
Northwest Cancer Center - Valparaiso
Valparaiso, Indiana 46383
Valparaiso, Indiana 46383
Mary Greeley Medical Center
Ames, Iowa 50010
Ames, Iowa 50010
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Ames
Ames, Iowa 50010
Ames, Iowa 50010
Mission Cancer and Blood - Ankeny
Ankeny, Iowa 50023
Ankeny, Iowa 50023
Contact:
Site Public Contact
515-282-2921
Site Public Contact
515-282-2921
McFarland Clinic - Boone
Boone, Iowa 50036
Boone, Iowa 50036
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
Saint Anthony Regional Hospital
Carroll, Iowa 51401
Carroll, Iowa 51401
Physicians' Clinic of Iowa PC
Cedar Rapids, Iowa 52402
Cedar Rapids, Iowa 52402
Contact:
Site Public Contact
319-297-2900
Site Public Contact
319-297-2900
Mercy Hospital
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids, Iowa 52403
Cedar Rapids, Iowa 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
Medical Oncology and Hematology Associates-West Des Moines
Clive, Iowa 50325
Clive, Iowa 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Clive, Iowa 50325
Alegent Health Mercy Hospital
Council Bluffs, Iowa 51503
Council Bluffs, Iowa 51503
Heartland Oncology and Hematology LLP
Council Bluffs, Iowa 51503
Council Bluffs, Iowa 51503
Contact:
Site Public Contact
712-322-4136
Site Public Contact
712-322-4136
Methodist Jennie Edmundson Hospital
Council Bluffs, Iowa 51503
Council Bluffs, Iowa 51503
Greater Regional Medical Center
Creston, Iowa 50801
Creston, Iowa 50801
Iowa Methodist Medical Center
Des Moines, Iowa 50309
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-241-6727
Site Public Contact
515-241-6727
Medical Oncology and Hematology Associates-Des Moines
Des Moines, Iowa 50309
Des Moines, Iowa 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Broadlawns Medical Center
Des Moines, Iowa 50314
Des Moines, Iowa 50314
Contact:
Site Public Contact
515-282-2200
Site Public Contact
515-282-2200
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Des Moines, Iowa 50314
Mission Cancer and Blood - Laurel
Des Moines, Iowa 50314
Des Moines, Iowa 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Iowa Lutheran Hospital
Des Moines, Iowa 50316
Des Moines, Iowa 50316
Contact:
Site Public Contact
515-241-8704
Site Public Contact
515-241-8704
McFarland Clinic - Trinity Cancer Center
Fort Dodge, Iowa 50501
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
Trinity Regional Medical Center
Fort Dodge, Iowa 50501
Fort Dodge, Iowa 50501
Contact:
Site Public Contact
515-574-8302
Site Public Contact
515-574-8302
McFarland Clinic - Jefferson
Jefferson, Iowa 50129
Jefferson, Iowa 50129
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Marshalltown
Marshalltown, Iowa 50158
Marshalltown, Iowa 50158
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
Methodist West Hospital
West Des Moines, Iowa 50266-7700
West Des Moines, Iowa 50266-7700
Contact:
Site Public Contact
515-343-1000
Site Public Contact
515-343-1000
Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
West Des Moines, Iowa 50266
Cancer Center of Kansas - Chanute
Chanute, Kansas 66720
Chanute, Kansas 66720
Cancer Center of Kansas - Dodge City
Dodge City, Kansas 67801
Dodge City, Kansas 67801
Cancer Center of Kansas - El Dorado
El Dorado, Kansas 67042
El Dorado, Kansas 67042
Central Care Cancer Center - Garden City
Garden City, Kansas 67846
Garden City, Kansas 67846
Central Care Cancer Center - Great Bend
Great Bend, Kansas 67530
Great Bend, Kansas 67530
HaysMed University of Kansas Health System
Hays, Kansas 67601
Hays, Kansas 67601
Contact:
Site Public Contact
785-623-5774
Site Public Contact
785-623-5774
Cancer Center of Kansas-Independence
Independence, Kansas 67301
Independence, Kansas 67301
Cancer Center of Kansas-Kingman
Kingman, Kansas 67068
Kingman, Kansas 67068
Lawrence Memorial Hospital
Lawrence, Kansas 66044
Lawrence, Kansas 66044
Cancer Center of Kansas-Liberal
Liberal, Kansas 67905
Liberal, Kansas 67905
Cancer Center of Kansas-Manhattan
Manhattan, Kansas 66502
Manhattan, Kansas 66502
Cancer Center of Kansas - McPherson
McPherson, Kansas 67460
McPherson, Kansas 67460
Cancer Center of Kansas - Newton
Newton, Kansas 67114
Newton, Kansas 67114
Olathe Health Cancer Center
Olathe, Kansas 66061
Olathe, Kansas 66061
Cancer Center of Kansas - Parsons
Parsons, Kansas 67357
Parsons, Kansas 67357
Ascension Via Christi - Pittsburg
Pittsburg, Kansas 66762
Pittsburg, Kansas 66762
Freeman Physician Group of Pittsburg
Pittsburg, Kansas 66762
Pittsburg, Kansas 66762
Cancer Center of Kansas - Pratt
Pratt, Kansas 67124
Pratt, Kansas 67124
Cancer Center of Kansas - Salina
Salina, Kansas 67401
Salina, Kansas 67401
Salina Regional Health Center
Salina, Kansas 67401
Salina, Kansas 67401
University of Kansas Health System Saint Francis Campus
Topeka, Kansas 66606
Topeka, Kansas 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
Cancer Center of Kansas - Wellington
Wellington, Kansas 67152
Wellington, Kansas 67152
Cancer Center of Kansas-Wichita Medical Arts Tower
Wichita, Kansas 67208
Wichita, Kansas 67208
Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214
Wichita, Kansas 67214
Cancer Center of Kansas - Wichita
Wichita, Kansas 67214
Wichita, Kansas 67214
Cancer Center of Kansas - Winfield
Winfield, Kansas 67156
Winfield, Kansas 67156
Flaget Memorial Hospital
Bardstown, Kentucky 40004
Bardstown, Kentucky 40004
Commonwealth Cancer Center-Corbin
Corbin, Kentucky 40701
Corbin, Kentucky 40701
Saint Joseph Hospital
Lexington, Kentucky 40504
Lexington, Kentucky 40504
Saint Joseph Radiation Oncology Resource Center
Lexington, Kentucky 40504
Lexington, Kentucky 40504
Saint Joseph Hospital East
Lexington, Kentucky 40509
Lexington, Kentucky 40509
Saint Joseph London
London, Kentucky 40741
London, Kentucky 40741
Saint Joseph Mount Sterling
Mount Sterling, Kentucky 40353
Mount Sterling, Kentucky 40353
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana 70805
Baton Rouge, Louisiana 70805
Our Lady of The Lake
Baton Rouge, Louisiana 70808
Baton Rouge, Louisiana 70808
Contact:
Site Public Contact
225-765-7659
Site Public Contact
225-765-7659
Louisiana Hematology Oncology Associates LLC
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Mary Bird Perkins Cancer Center
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Our Lady of the Lake Physicians Group - Medical Oncology
Baton Rouge, Louisiana 70809
Baton Rouge, Louisiana 70809
Medical Center of Baton Rouge
Baton Rouge, Louisiana 70816
Baton Rouge, Louisiana 70816
Ochsner High Grove
Baton Rouge, Louisiana 70836
Baton Rouge, Louisiana 70836
Northshore Oncology Associates-Covington
Covington, Louisiana 70433
Covington, Louisiana 70433
Ochsner Hematology Oncology North Shore - Covington (West Region)
Covington, Louisiana 70433
Covington, Louisiana 70433
Terrebonne General Medical Center
Houma, Louisiana 70360
Houma, Louisiana 70360
Ochsner Medical Center Kenner
Kenner, Louisiana 70065
Kenner, Louisiana 70065
Ochsner Medical Center Jefferson
New Orleans, Louisiana 70121
New Orleans, Louisiana 70121
Harold Alfond Center for Cancer Care
Augusta, Maine 04330
Augusta, Maine 04330
Contact:
Site Public Contact
207-626-4855
Site Public Contact
207-626-4855
Eastern Maine Medical Center
Bangor, Maine 04401
Bangor, Maine 04401
Contact:
Site Public Contact
207-973-4274
Site Public Contact
207-973-4274
Waldo County General Hospital
Belfast, Maine 04915
Belfast, Maine 04915
Contact:
Site Public Contact
207-338-2500
Site Public Contact
207-338-2500
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford
Biddeford, Maine 04005
Biddeford, Maine 04005
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Brewer, Maine 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
Penobscot Bay Medical Center
Rockport, Maine 04856
Rockport, Maine 04856
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford
Sanford, Maine 04073
Sanford, Maine 04073
Maine Medical Partners - South Portland
South Portland, Maine 04106
South Portland, Maine 04106
UM Upper Chesapeake Hematology and Oncology - Aberdeen
Aberdeen, Maryland 21001
Aberdeen, Maryland 21001
Greater Baltimore Medical Center
Baltimore, Maryland 21204
Baltimore, Maryland 21204
Contact:
Site Public Contact
443-849-3706
Site Public Contact
443-849-3706
MedStar Franklin Square Medical Center/Weinberg Cancer Institute
Baltimore, Maryland 21237
Baltimore, Maryland 21237
Contact:
Site Public Contact
443-777-7364
Site Public Contact
443-777-7364
MedStar Good Samaritan Hospital
Baltimore, Maryland 21239
Baltimore, Maryland 21239
Kaiser Permanente-Woodlawn Medical Center
Baltimore, Maryland 21244
Baltimore, Maryland 21244
Contact:
Site Public Contact
301-816-7218
Site Public Contact
301-816-7218
UM Upper Chesapeake Medical Center
Bel Air, Maryland 21014
Bel Air, Maryland 21014
Contact:
Site Public Contact
443-643-3010
Site Public Contact
443-643-3010
University of Maryland Shore Medical Center at Easton
Easton, Maryland 21601
Easton, Maryland 21601
Christiana Care - Union Hospital
Elkton, Maryland 21921
Elkton, Maryland 21921
Kaiser Permanente-Gaithersburg Medical Center
Gaithersburg, Maryland 20879
Gaithersburg, Maryland 20879
Contact:
Site Public Contact
301-816-7218
Site Public Contact
301-816-7218
Kaiser Permanente - Kensington Medical Center
Kensington, Maryland 20895
Kensington, Maryland 20895
Contact:
Site Public Contact
301-816-7218
Site Public Contact
301-816-7218
Kaiser Permanente - Largo Medical Center
Largo, Maryland 20774
Largo, Maryland 20774
Contact:
Site Public Contact
301-816-7446
Site Public Contact
301-816-7446
Kaiser Permanente Lutherville - Timonium Medical Center
Lutherville, Maryland 21093
Lutherville, Maryland 21093
Contact:
Site Public Contact
410-847-3000
Site Public Contact
410-847-3000
Tufts Medical Center
Boston, Massachusetts 02111
Boston, Massachusetts 02111
Beth Israel Deaconess Hospital-Plymouth
Plymouth, Massachusetts 02360
Plymouth, Massachusetts 02360
Saint Joseph Mercy Hospital
Ann Arbor, Michigan 48106
Ann Arbor, Michigan 48106
Bronson Battle Creek
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
Saint Joseph Mercy Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Saint Joseph Mercy Canton
Canton, Michigan 48188
Canton, Michigan 48188
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan 48188
Canton, Michigan 48188
Caro Cancer Center
Caro, Michigan 48723
Caro, Michigan 48723
Saint Joseph Mercy Chelsea
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
Clarkston, Michigan 48346
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
Clarkston, Michigan 48346
Beaumont Hospital - Dearborn
Dearborn, Michigan 48124
Dearborn, Michigan 48124
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Ascension Saint John Hospital
Detroit, Michigan 48236
Detroit, Michigan 48236
Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan 48054
East China Township, Michigan 48054
Beaumont Hospital - Farmington Hills
Farmington Hills, Michigan 48336
Farmington Hills, Michigan 48336
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Genesee Cancer and Blood Disease Treatment Center
Flint, Michigan 48503
Flint, Michigan 48503
Genesee Hematology Oncology PC
Flint, Michigan 48503
Flint, Michigan 48503
Genesys Hurley Cancer Institute
Flint, Michigan 48503
Flint, Michigan 48503
Hurley Medical Center
Flint, Michigan 48503
Flint, Michigan 48503
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Academic Hematology Oncology Specialists
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
West Michigan Cancer Center
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
Ascension Borgess Cancer Center
Kalamazoo, Michigan 49009
Kalamazoo, Michigan 49009
Borgess Medical Center
Kalamazoo, Michigan 49048
Kalamazoo, Michigan 49048
University of Michigan Health - Sparrow Lansing
Lansing, Michigan 48912
Lansing, Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
Livonia, Michigan 48154
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb, Michigan 48044
Macomb, Michigan 48044
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette, Michigan 48453
Marlette, Michigan 48453
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
Muskegon, Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan 49120
Niles, Michigan 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan 49444
Norton Shores, Michigan 49444
21st Century Oncology-Pontiac
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Hope Cancer Center
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Saint Joseph Mercy Oakland
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Corewell Health Reed City Hospital
Reed City, Michigan 49677
Reed City, Michigan 49677
Oakland Colon Rectal Associates
Royal Oak, Michigan 48067
Royal Oak, Michigan 48067
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Cancer Care Associates PC
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Comprehensive Medical Center PLLC
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Hematology Oncology Consultants PC
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Oakland Medical Group
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Ascension Saint Mary's Hospital
Saginaw, Michigan 48601
Saginaw, Michigan 48601
Oncology Hematology Associates of Saginaw Valley PC
Saginaw, Michigan 48604
Saginaw, Michigan 48604
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Lakeland Medical Center Saint Joseph
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights, Michigan 48312
Sterling Heights, Michigan 48312
Premier Hematology Oncology Care
Sterling Heights, Michigan 48312
Sterling Heights, Michigan 48312
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Ascension Saint Joseph Hospital
Tawas City, Michigan 48764
Tawas City, Michigan 48764
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
Michigan Institute of Urology-Town Center
Troy, Michigan 48084
Troy, Michigan 48084
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
William Beaumont Hospital - Troy
Troy, Michigan 48085
Troy, Michigan 48085
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Hematology Oncology Consultants PC-Troy
Troy, Michigan 48098
Troy, Michigan 48098
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Advanced Breast Care Center PLLC
Warren, Michigan 48088
Warren, Michigan 48088
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren, Michigan 48093
Warren, Michigan 48093
Macomb Hematology Oncology PC
Warren, Michigan 48093
Warren, Michigan 48093
Michigan Breast Specialists-Warren
Warren, Michigan 48093
Warren, Michigan 48093
Saint John Macomb-Oakland Hospital
Warren, Michigan 48093
Warren, Michigan 48093
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch, Michigan 48661
West Branch, Michigan 48661
University of Michigan Health - West
Wyoming, Michigan 49519
Wyoming, Michigan 49519
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
Ypsilanti, Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
Ypsilanti, Michigan 48197
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
Minnesota Oncology - Burnsville
Burnsville, Minnesota 55337
Burnsville, Minnesota 55337
Cambridge Medical Center
Cambridge, Minnesota 55008
Cambridge, Minnesota 55008
Mercy Hospital
Coon Rapids, Minnesota 55433
Coon Rapids, Minnesota 55433
Fairview Southdale Hospital
Edina, Minnesota 55435
Edina, Minnesota 55435
Mayo Clinic Health Systems-Mankato
Mankato, Minnesota 56001
Mankato, Minnesota 56001
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota 55369
Maple Grove, Minnesota 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota 55109
Maplewood, Minnesota 55109
Saint John's Hospital - Healtheast
Maplewood, Minnesota 55109
Maplewood, Minnesota 55109
Abbott-Northwestern Hospital
Minneapolis, Minnesota 55407
Minneapolis, Minnesota 55407
Hennepin County Medical Center
Minneapolis, Minnesota 55415
Minneapolis, Minnesota 55415
Minneapolis VA Medical Center
Minneapolis, Minnesota 55417
Minneapolis, Minnesota 55417
Contact:
Site Public Contact
612-467-2800
Site Public Contact
612-467-2800
Health Partners Inc
Minneapolis, Minnesota 55454
Minneapolis, Minnesota 55454
Monticello Cancer Center
Monticello, Minnesota 55362
Monticello, Minnesota 55362
New Ulm Medical Center
New Ulm, Minnesota 56073
New Ulm, Minnesota 56073
Fairview Northland Medical Center
Princeton, Minnesota 55371
Princeton, Minnesota 55371
North Memorial Medical Health Center
Robbinsdale, Minnesota 55422
Robbinsdale, Minnesota 55422
Mayo Clinic in Rochester
Rochester, Minnesota 55905
Rochester, Minnesota 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud, Minnesota 56303
Saint Cloud, Minnesota 56303
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota 55416
Saint Louis Park, Minnesota 55416
Regions Hospital
Saint Paul, Minnesota 55101
Saint Paul, Minnesota 55101
United Hospital
Saint Paul, Minnesota 55102
Saint Paul, Minnesota 55102
Saint Francis Regional Medical Center
Shakopee, Minnesota 55379
Shakopee, Minnesota 55379
Lakeview Hospital
Stillwater, Minnesota 55082
Stillwater, Minnesota 55082
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota 56701
Thief River Falls, Minnesota 56701
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Ridgeview Medical Center
Waconia, Minnesota 55387
Waconia, Minnesota 55387
Rice Memorial Hospital
Willmar, Minnesota 56201
Willmar, Minnesota 56201
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota 55125
Woodbury, Minnesota 55125
Sanford Cancer Center Worthington
Worthington, Minnesota 56187
Worthington, Minnesota 56187
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Fairview Lakes Medical Center
Wyoming, Minnesota 55092
Wyoming, Minnesota 55092
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin, Missouri 63011
Ballwin, Missouri 63011
Contact:
Site Public Contact
314-251-7058
Site Public Contact
314-251-7058
Central Care Cancer Center - Bolivar
Bolivar, Missouri 65613
Bolivar, Missouri 65613
Cox Cancer Center Branson
Branson, Missouri 65616
Branson, Missouri 65616
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
Southeast Cancer Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
Contact:
Site Public Contact
573-651-5550
Site Public Contact
573-651-5550
Siteman Cancer Center at West County Hospital
Creve Coeur, Missouri 63141
Creve Coeur, Missouri 63141
Parkland Health Center - Farmington
Farmington, Missouri 63640
Farmington, Missouri 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Capital Region Southwest Campus
Jefferson City, Missouri 65109
Jefferson City, Missouri 65109
Freeman Health System
Joplin, Missouri 64804
Joplin, Missouri 64804
Mercy Hospital Joplin
Joplin, Missouri 64804
Joplin, Missouri 64804
Truman Medical Centers
Kansas City, Missouri 64108
Kansas City, Missouri 64108
Contact:
Site Public Contact
816-404-4375
Site Public Contact
816-404-4375
Saint Luke's Hospital of Kansas City
Kansas City, Missouri 64111
Kansas City, Missouri 64111
Saint Luke's East - Lee's Summit
Lee's Summit, Missouri 64086
Lee's Summit, Missouri 64086
Lake Regional Hospital
Osage Beach, Missouri 65065
Osage Beach, Missouri 65065
Delbert Day Cancer Institute at PCRMC
Rolla, Missouri 65401
Rolla, Missouri 65401
Mercy Clinic-Rolla-Cancer and Hematology
Rolla, Missouri 65401
Rolla, Missouri 65401
Contact:
Site Public Contact
573-458-6379
Site Public Contact
573-458-6379
Heartland Regional Medical Center
Saint Joseph, Missouri 64506
Saint Joseph, Missouri 64506
Saint Louis Cancer and Breast Institute-South City
Saint Louis, Missouri 63109
Saint Louis, Missouri 63109
Contact:
Site Public Contact
314-353-1870
Site Public Contact
314-353-1870
Washington University School of Medicine
Saint Louis, Missouri 63110
Saint Louis, Missouri 63110
Mercy Hospital South
Saint Louis, Missouri 63128
Saint Louis, Missouri 63128
Siteman Cancer Center-South County
Saint Louis, Missouri 63129
Saint Louis, Missouri 63129
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Siteman Cancer Center at Christian Hospital
Saint Louis, Missouri 63136
Saint Louis, Missouri 63136
Mercy Hospital Saint Louis
Saint Louis, Missouri 63141
Saint Louis, Missouri 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Siteman Cancer Center at Saint Peters Hospital
Saint Peters, Missouri 63376
Saint Peters, Missouri 63376
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
Sainte Genevieve, Missouri 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield, Missouri 65804
Springfield, Missouri 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield, Missouri 65807
Springfield, Missouri 65807
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
Sullivan, Missouri 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
Sunset Hills, Missouri 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Washington
Washington, Missouri 63090
Washington, Missouri 63090
Contact:
Site Public Contact
636-390-1600
Site Public Contact
636-390-1600
Community Hospital of Anaconda
Anaconda, Montana 59711
Anaconda, Montana 59711
Billings Clinic Cancer Center
Billings, Montana 59101
Billings, Montana 59101
Bozeman Deaconess Hospital
Bozeman, Montana 59715
Bozeman, Montana 59715
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
Great Falls, Montana 59405
Great Falls Clinic
Great Falls, Montana 59405
Great Falls, Montana 59405
Kalispell Regional Medical Center
Kalispell, Montana 59901
Kalispell, Montana 59901
Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
Missoula, Montana 59802
Community Medical Hospital
Missoula, Montana 59804
Missoula, Montana 59804
CHI Health Good Samaritan
Kearney, Nebraska 68847
Kearney, Nebraska 68847
Saint Elizabeth Regional Medical Center
Lincoln, Nebraska 68510
Lincoln, Nebraska 68510
Cancer Partners of Nebraska - Pine Lake
Lincoln, Nebraska 68516
Lincoln, Nebraska 68516
Southeast Nebraska Cancer Center - 68th Street Place
Lincoln, Nebraska 68516
Lincoln, Nebraska 68516
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Contact:
Site Public Contact
402-334-4773
Site Public Contact
402-334-4773
Nebraska Methodist Hospital
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Contact:
Site Public Contact
402-354-5144
Site Public Contact
402-354-5144
Oncology Associates PC
Omaha, Nebraska 68114
Omaha, Nebraska 68114
Alegent Health Immanuel Medical Center
Omaha, Nebraska 68122
Omaha, Nebraska 68122
Alegent Health Bergan Mercy Medical Center
Omaha, Nebraska 68124
Omaha, Nebraska 68124
Alegent Health Lakeside Hospital
Omaha, Nebraska 68130
Omaha, Nebraska 68130
Creighton University Medical Center
Omaha, Nebraska 68131
Omaha, Nebraska 68131
Midlands Community Hospital
Papillion, Nebraska 68046
Papillion, Nebraska 68046
Carson Tahoe Regional Medical Center
Carson City, Nevada 89703
Carson City, Nevada 89703
Cancer and Blood Specialists-Henderson
Henderson, Nevada 89052
Henderson, Nevada 89052
Comprehensive Cancer Centers of Nevada - Henderson
Henderson, Nevada 89052
Henderson, Nevada 89052
Comprehensive Cancer Centers of Nevada-Horizon Ridge
Henderson, Nevada 89052
Henderson, Nevada 89052
OptumCare Cancer Care at Seven Hills
Henderson, Nevada 89052
Henderson, Nevada 89052
Comprehensive Cancer Centers of Nevada-Southeast Henderson
Henderson, Nevada 89074
Henderson, Nevada 89074
GenesisCare USA - Henderson
Henderson, Nevada 89074
Henderson, Nevada 89074
Las Vegas Urology - Green Valley
Henderson, Nevada 89074
Henderson, Nevada 89074
Urology Specialists of Nevada - Green Valley
Henderson, Nevada 89074
Henderson, Nevada 89074
OptumCare Cancer Care at Charleston
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
University Medical Center of Southern Nevada
Las Vegas, Nevada 89102
Las Vegas, Nevada 89102
Hope Cancer Care of Nevada
Las Vegas, Nevada 89103
Las Vegas, Nevada 89103
Radiation Oncology Centers of Nevada Central
Las Vegas, Nevada 89106
Las Vegas, Nevada 89106
Urology Specialists of Nevada - Central
Las Vegas, Nevada 89106
Las Vegas, Nevada 89106
GenesisCare USA - Las Vegas
Las Vegas, Nevada 89109
Las Vegas, Nevada 89109
Sunrise Hospital and Medical Center
Las Vegas, Nevada 89109
Las Vegas, Nevada 89109
Las Vegas Prostate Cancer Center
Las Vegas, Nevada 89113
Las Vegas, Nevada 89113
Urology Specialists of Nevada - Southwest
Las Vegas, Nevada 89113
Las Vegas, Nevada 89113
Radiation Oncology Centers of Nevada Southeast
Las Vegas, Nevada 89119
Las Vegas, Nevada 89119
Ann M Wierman MD LTD
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Comprehensive Cancer Centers of Nevada - Northwest
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
GenesisCare USA - Vegas Tenaya
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Las Vegas Urology - Cathedral Rock
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Las Vegas Urology - Smoke Ranch
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
OptumCare Cancer Care at MountainView
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Urology Specialists of Nevada - Northwest
Las Vegas, Nevada 89128
Las Vegas, Nevada 89128
Alliance for Childhood Diseases/Cure 4 the Kids Foundation
Las Vegas, Nevada 89135
Las Vegas, Nevada 89135
Comprehensive Cancer Centers of Nevada - Town Center
Las Vegas, Nevada 89144
Las Vegas, Nevada 89144
Comprehensive Cancer Centers of Nevada-Summerlin
Las Vegas, Nevada 89144
Las Vegas, Nevada 89144
Summerlin Hospital Medical Center
Las Vegas, Nevada 89144
Las Vegas, Nevada 89144
Comprehensive Cancer Centers of Nevada
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
GenesisCare USA - Fort Apache
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
OptumCare Cancer Care at Fort Apache
Las Vegas, Nevada 89148
Las Vegas, Nevada 89148
Comprehensive Cancer Centers of Nevada - Central Valley
Las Vegas, Nevada 89169
Las Vegas, Nevada 89169
University Cancer Center
Las Vegas, Nevada 89169
Las Vegas, Nevada 89169
Hope Cancer Care of Nevada-Pahrump
Pahrump, Nevada 89048
Pahrump, Nevada 89048
Renown Regional Medical Center
Reno, Nevada 89502
Reno, Nevada 89502
Saint Mary's Regional Medical Center
Reno, Nevada 89503
Reno, Nevada 89503
Radiation Oncology Associates
Reno, Nevada 89509
Reno, Nevada 89509
Inspira Medical Center Mullica Hill
Mullica Hill, New Jersey 08062
Mullica Hill, New Jersey 08062
Holy Name Hospital
Teaneck, New Jersey 07666
Teaneck, New Jersey 07666
Contact:
Site Public Contact
201-833-6312
Site Public Contact
201-833-6312
University of New Mexico Cancer Center
Albuquerque, New Mexico 87102
Albuquerque, New Mexico 87102
Hematology Oncology Associates of Central New York-Auburn
Auburn, New York 13021
Auburn, New York 13021
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
Montefiore Medical Center-Einstein Campus
Bronx, New York 10461
Bronx, New York 10461
Montefiore Medical Center-Weiler Hospital
Bronx, New York 10461
Bronx, New York 10461
Montefiore Medical Center - Moses Campus
Bronx, New York 10467
Bronx, New York 10467
Mary Imogene Bassett Hospital
Cooperstown, New York 13326
Cooperstown, New York 13326
Hematology Oncology Associates of Central New York-East Syracuse
East Syracuse, New York 13057
East Syracuse, New York 13057
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
Glens Falls Hospital
Glens Falls, New York 12801
Glens Falls, New York 12801
Contact:
Site Public Contact
518-926-6700
Site Public Contact
518-926-6700
Hematology Oncology Associates of Central New York-Onondaga Hill
Syracuse, New York 13215
Syracuse, New York 13215
Contact:
Site Public Contact
315-472-7504
Site Public Contact
315-472-7504
AdventHealth Infusion Center Asheville
Asheville, North Carolina 28803
Asheville, North Carolina 28803
AdventHealth Infusion Center Haywood
Clyde, North Carolina 28721
Clyde, North Carolina 28721
AdventHealth Hendersonville
Hendersonville, North Carolina 28792
Hendersonville, North Carolina 28792
Marion L Shepard Cancer Center at Vidant Beaufort Hospital
Washington, North Carolina 27889
Washington, North Carolina 27889
AdventHealth Infusion Center Weaverville
Weaverville, North Carolina 28787
Weaverville, North Carolina 28787
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
Sanford South University Medical Center
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Contact:
Site Public Contact
701-234-6161
Site Public Contact
701-234-6161
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Sanford Medical Center Fargo
Fargo, North Dakota 58104
Fargo, North Dakota 58104
Contact:
Site Public Contact
800-437-4010
Site Public Contact
800-437-4010
Sanford Broadway Medical Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Altru Cancer Center
Grand Forks, North Dakota 58201
Grand Forks, North Dakota 58201
Contact:
Site Public Contact
701-780-6520
Site Public Contact
701-780-6520
Cleveland Clinic Akron General
Akron, Ohio 44307
Akron, Ohio 44307
Aultman Alliance Community Hospital
Alliance, Ohio 44601
Alliance, Ohio 44601
Contact:
Site Public Contact
330-363-1250
Site Public Contact
330-363-1250
Indu and Raj Soin Medical Center
Beavercreek, Ohio 45431
Beavercreek, Ohio 45431
Saint Elizabeth Boardman Hospital
Boardman, Ohio 44512
Boardman, Ohio 44512
Aultman Health Foundation
Canton, Ohio 44710
Canton, Ohio 44710
Dayton Physicians LLC-Miami Valley South
Centerville, Ohio 45459
Centerville, Ohio 45459
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati, Ohio 45219
Cincinnati, Ohio 45219
Good Samaritan Hospital - Cincinnati
Cincinnati, Ohio 45220
Cincinnati, Ohio 45220
Oncology Hematology Care Inc-Kenwood
Cincinnati, Ohio 45236
Cincinnati, Ohio 45236
Bethesda North Hospital
Cincinnati, Ohio 45242
Cincinnati, Ohio 45242
TriHealth Cancer Institute-Westside
Cincinnati, Ohio 45247
Cincinnati, Ohio 45247
TriHealth Cancer Institute-Anderson
Cincinnati, Ohio 45255
Cincinnati, Ohio 45255
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland, Ohio 44111
Cleveland, Ohio 44111
Dayton Physician LLC-Miami Valley Hospital North
Dayton, Ohio 45415
Dayton, Ohio 45415
Armes Family Cancer Center
Findlay, Ohio 45840
Findlay, Ohio 45840
Blanchard Valley Hospital
Findlay, Ohio 45840
Findlay, Ohio 45840
Orion Cancer Care
Findlay, Ohio 45840
Findlay, Ohio 45840
Dayton Physicians LLC-Atrium
Franklin, Ohio 45005
Franklin, Ohio 45005
Dayton Physicians LLC-Wayne
Greenville, Ohio 45331
Greenville, Ohio 45331
Wayne Hospital
Greenville, Ohio 45331
Greenville, Ohio 45331
Cleveland Clinic Cancer Center Independence
Independence, Ohio 44131
Independence, Ohio 44131
Greater Dayton Cancer Center
Kettering, Ohio 45409
Kettering, Ohio 45409
Kettering Medical Center
Kettering, Ohio 45429
Kettering, Ohio 45429
Cleveland Clinic Cancer Center Mansfield
Mansfield, Ohio 44906
Mansfield, Ohio 44906
Hillcrest Hospital Cancer Center
Mayfield Heights, Ohio 44124
Mayfield Heights, Ohio 44124
North Coast Cancer Care
Sandusky, Ohio 44870
Sandusky, Ohio 44870
Trinity's Tony Teramana Cancer Center
Steubenville, Ohio 43952
Steubenville, Ohio 43952
Contact:
Site Public Contact
888-874-7000
Site Public Contact
888-874-7000
Cleveland Clinic Cancer Center Strongsville
Strongsville, Ohio 44136
Strongsville, Ohio 44136
ProMedica Flower Hospital
Sylvania, Ohio 43560
Sylvania, Ohio 43560
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo, Ohio 43606
Toledo, Ohio 43606
Dayton Physicians LLC - Troy
Troy, Ohio 45373
Troy, Ohio 45373
South Pointe Hospital
Warrensville Heights, Ohio 44122
Warrensville Heights, Ohio 44122
Saint Joseph Warren Hospital
Warren, Ohio 44484
Warren, Ohio 44484
University of Cincinnati Cancer Center-West Chester
West Chester, Ohio 45069
West Chester, Ohio 45069
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster, Ohio 44691
Wooster, Ohio 44691
Wright-Patterson Medical Center
Wright-Patterson Air Force Base, Ohio 45433
Wright-Patterson Air Force Base, Ohio 45433
Saint Elizabeth Youngstown Hospital
Youngstown, Ohio 44501
Youngstown, Ohio 44501
Cancer Centers of Southwest Oklahoma Research
Lawton, Oklahoma 73505
Lawton, Oklahoma 73505
Contact:
Site Public Contact
877-231-4440
Site Public Contact
877-231-4440
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Integris Southwest Medical Center
Oklahoma City, Oklahoma 73109
Oklahoma City, Oklahoma 73109
Mercy Hospital Oklahoma City
Oklahoma City, Oklahoma 73120
Oklahoma City, Oklahoma 73120
Contact:
Site Public Contact
405-752-3402
Site Public Contact
405-752-3402
Integris Cancer Institute of Oklahoma
Oklahoma City, Oklahoma 73142
Oklahoma City, Oklahoma 73142
Contact:
Site Public Contact
405-773-6613
Site Public Contact
405-773-6613
Saint Alphonsus Medical Center-Baker City
Baker City, Oregon 97814
Baker City, Oregon 97814
Saint Charles Health System
Bend, Oregon 97701
Bend, Oregon 97701
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Providence Cancer Institute Clackamas Clinic
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Bay Area Hospital
Coos Bay, Oregon 97420
Coos Bay, Oregon 97420
Providence Newberg Medical Center
Newberg, Oregon 97132
Newberg, Oregon 97132
Saint Alphonsus Medical Center-Ontario
Ontario, Oregon 97914
Ontario, Oregon 97914
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
Oregon City, Oregon 97045
Providence Portland Medical Center
Portland, Oregon 97213
Portland, Oregon 97213
Providence Saint Vincent Medical Center
Portland, Oregon 97225
Portland, Oregon 97225
Saint Charles Health System-Redmond
Redmond, Oregon 97756
Redmond, Oregon 97756
Contact:
Site Public Contact
541-706-2909
Site Public Contact
541-706-2909
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
Allentown, Pennsylvania 18103
UPMC Altoona
Altoona, Pennsylvania 16601
Altoona, Pennsylvania 16601
UPMC-Heritage Valley Health System Beaver
Beaver, Pennsylvania 15009
Beaver, Pennsylvania 15009
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017
Bethlehem, Pennsylvania 18017
UPMC Hillman Cancer Center at Butler Health System
Butler, Pennsylvania 16001
Butler, Pennsylvania 16001
Carlisle Regional Cancer Center
Carlisle, Pennsylvania 17015
Carlisle, Pennsylvania 17015
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
Chadds Ford, Pennsylvania 19317
Patterson Cancer Center at UPMC Cole
Coudersport, Pennsylvania 16915
Coudersport, Pennsylvania 16915
Geisinger Medical Center
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
East Stroudsburg, Pennsylvania 18301
UPMC Hillman Cancer Center Erie
Erie, Pennsylvania 16505
Erie, Pennsylvania 16505
UPMC Cancer Center at UPMC Horizon
Farrell, Pennsylvania 16121
Farrell, Pennsylvania 16121
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg, Pennsylvania 15601
Greensburg, Pennsylvania 15601
Contact:
Site Public Contact
724-838-1900
Site Public Contact
724-838-1900
Oncology Hematology Associates
Greenville, Pennsylvania 16125
Greenville, Pennsylvania 16125
UPMC Pinnacle Harrisburg
Harrisburg, Pennsylvania 17101
Harrisburg, Pennsylvania 17101
UPMC Pinnacle Cancer Center/Community Osteopathic Campus
Harrisburg, Pennsylvania 17109
Harrisburg, Pennsylvania 17109
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania 18201
Hazleton, Pennsylvania 18201
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
Hazleton, Pennsylvania 18201
IRMC Cancer Center
Indiana, Pennsylvania 15701
Indiana, Pennsylvania 15701
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown, Pennsylvania 15901
Johnstown, Pennsylvania 15901
Contact:
Site Public Contact
814-534-4724
Site Public Contact
814-534-4724
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania 17837
Lewisburg, Pennsylvania 17837
UPMC Cancer Center at UPMC McKeesport
McKeesport, Pennsylvania 15132
McKeesport, Pennsylvania 15132
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC Hillman Cancer Center at Rocco And Nancy Ortenzio Cancer Pavilion
Mechanicsburg, Pennsylvania 17050
Mechanicsburg, Pennsylvania 17050
UPMC Hillman Cancer Center - Monroeville
Monroeville, Pennsylvania 15146
Monroeville, Pennsylvania 15146
UPMC Hillman Cancer Center in Coraopolis
Moon, Pennsylvania 15108
Moon, Pennsylvania 15108
UPMC Hillman Cancer Center - Part of Frick Hospital
Mount Pleasant, Pennsylvania 15666
Mount Pleasant, Pennsylvania 15666
Arnold Palmer Cancer Center Medical Oncology Norwin
N. Huntingdon, Pennsylvania 15642
N. Huntingdon, Pennsylvania 15642
UPMC Cancer Center-Natrona Heights
Natrona Heights, Pennsylvania 15065
Natrona Heights, Pennsylvania 15065
Contact:
Site Public Contact
724-230-3030
Site Public Contact
724-230-3030
UPMC Hillman Cancer Center - New Castle
New Castle, Pennsylvania 16105
New Castle, Pennsylvania 16105
UPMC-Saint Margaret
Pittsburgh, Pennsylvania 15215
Pittsburgh, Pennsylvania 15215
Contact:
Site Public Contact
412-784-4900
Site Public Contact
412-784-4900
UPMC-Mercy Hospital
Pittsburgh, Pennsylvania 15219
Pittsburgh, Pennsylvania 15219
Contact:
Site Public Contact
800-533-8762
Site Public Contact
800-533-8762
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh, Pennsylvania 15232
Pittsburgh, Pennsylvania 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC-Passavant Hospital
Pittsburgh, Pennsylvania 15237
Pittsburgh, Pennsylvania 15237
Contact:
Site Public Contact
412-367-6454
Site Public Contact
412-367-6454
UPMC-Saint Clair Hospital Cancer Center
Pittsburgh, Pennsylvania 15243
Pittsburgh, Pennsylvania 15243
Contact:
Site Public Contact
412-502-3920
Site Public Contact
412-502-3920
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania 17901
Pottsville, Pennsylvania 17901
Guthrie Medical Group PC-Robert Packer Hospital
Sayre, Pennsylvania 18840
Sayre, Pennsylvania 18840
Contact:
Site Public Contact
800-836-0388
Site Public Contact
800-836-0388
Community Medical Center
Scranton, Pennsylvania 18510
Scranton, Pennsylvania 18510
Geisinger Medical Oncology-Selinsgrove
Selinsgrove, Pennsylvania 17870
Selinsgrove, Pennsylvania 17870
UPMC Cancer Center at UPMC Northwest
Seneca, Pennsylvania 16346
Seneca, Pennsylvania 16346
Contact:
Site Public Contact
814-676-7900
Site Public Contact
814-676-7900
UPMC Cancer Center-Uniontown
Uniontown, Pennsylvania 15401
Uniontown, Pennsylvania 15401
UPMC Cancer Center-Washington
Washington, Pennsylvania 15301
Washington, Pennsylvania 15301
UPMC West Mifflin-Cancer Center Jefferson
West Mifflin, Pennsylvania 15122
West Mifflin, Pennsylvania 15122
Contact:
Site Public Contact
412-653-8100
Site Public Contact
412-653-8100
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
Wilkes-Barre, Pennsylvania 18711
Divine Providence Hospital
Williamsport, Pennsylvania 17754
Williamsport, Pennsylvania 17754
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania 19090
Willow Grove, Pennsylvania 19090
UPMC Memorial
York, Pennsylvania 17408
York, Pennsylvania 17408
Contact:
Site Public Contact
717-724-6760
Site Public Contact
717-724-6760
Beaufort Memorial Hospital
Beaufort, South Carolina 29902
Beaufort, South Carolina 29902
Prisma Health Cancer Institute - Spartanburg
Boiling Springs, South Carolina 29316
Boiling Springs, South Carolina 29316
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Medical University of South Carolina
Charleston, South Carolina 29425
Charleston, South Carolina 29425
Prisma Health Cancer Institute - Easley
Easley, South Carolina 29640
Easley, South Carolina 29640
Tidelands Georgetown Memorial Hospital
Georgetown, South Carolina 29440
Georgetown, South Carolina 29440
Prisma Health Cancer Institute - Butternut
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Faris
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Eastside
Greenville, South Carolina 29615
Greenville, South Carolina 29615
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Self Regional Healthcare
Greenwood, South Carolina 29646
Greenwood, South Carolina 29646
Prisma Health Cancer Institute - Greer
Greer, South Carolina 29650
Greer, South Carolina 29650
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Seneca
Seneca, South Carolina 29672
Seneca, South Carolina 29672
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Sioux Falls, South Dakota 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Sioux Falls, South Dakota 57117-5134
Bristol Regional Medical Center
Bristol, Tennessee 37620
Bristol, Tennessee 37620
Cookeville Regional Medical Center
Cookeville, Tennessee 38501
Cookeville, Tennessee 38501
Contact:
Site Public Contact
931-783-2714
Site Public Contact
931-783-2714
Ballad Health Cancer Care - Kingsport
Kingsport, Tennessee 37660
Kingsport, Tennessee 37660
Wellmont Holston Valley Hospital and Medical Center
Kingsport, Tennessee 37660
Kingsport, Tennessee 37660
Dell Seton Medical Center at The University of Texas
Austin, Texas 78701
Austin, Texas 78701
Contact:
Site Public Contact
512-324-7991
Site Public Contact
512-324-7991
University of Texas at Austin
Austin, Texas 78712
Austin, Texas 78712
Central Vermont Medical Center/National Life Cancer Treatment
Berlin, Vermont 05602
Berlin, Vermont 05602
Contact:
Site Public Contact
802-225-5400
Site Public Contact
802-225-5400
University of Vermont Medical Center
Burlington, Vermont 05401
Burlington, Vermont 05401
University of Vermont and State Agricultural College
Burlington, Vermont 05405
Burlington, Vermont 05405
Wellmont Medical Associates-Bristol
Bristol, Virginia 24201
Bristol, Virginia 24201
Kaiser Permanente-Burke Medical Center
Burke, Virginia 22015
Burke, Virginia 22015
Inova Schar Cancer Institute
Fairfax, Virginia 22031
Fairfax, Virginia 22031
Inova Fair Oaks Hospital
Fairfax, Virginia 22033
Fairfax, Virginia 22033
Inova Fairfax Hospital
Falls Church, Virginia 22042
Falls Church, Virginia 22042
Sovah Health Martinsville
Martinsville, Virginia 24115
Martinsville, Virginia 24115
Kaiser Permanente Tysons Corner Medical Center
McLean, Virginia 22102
McLean, Virginia 22102
Contact:
Site Public Contact
240-632-4284
Site Public Contact
240-632-4284
Bon Secours Memorial Regional Medical Center
Mechanicsville, Virginia 23116
Mechanicsville, Virginia 23116
Bon Secours Westchester Emergency Center
Midlothian, Virginia 23113
Midlothian, Virginia 23113
Bon Secours Saint Francis Medical Center
Midlothian, Virginia 23114
Midlothian, Virginia 23114
Southwest VA Regional Cancer Center
Norton, Virginia 24273
Norton, Virginia 24273
Bon Secours Richmond Community Hospital
Richmond, Virginia 23223
Richmond, Virginia 23223
Bon Secours Saint Mary's Hospital
Richmond, Virginia 23226
Richmond, Virginia 23226
Virginia Cancer Institute
Richmond, Virginia 23229
Richmond, Virginia 23229
Bon Secours Cancer Institute at Reynolds Crossing
Richmond, Virginia 23230
Richmond, Virginia 23230
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
Richmond, Virginia 23235
Virginia Commonwealth University/Massey Cancer Center
Richmond, Virginia 23298
Richmond, Virginia 23298
VCU Community Memorial Health Center
South Hill, Virginia 23970
South Hill, Virginia 23970
Shenandoah Oncology PC
Winchester, Virginia 22601
Winchester, Virginia 22601
Kaiser Permanente-Caton Hill Medical Center
Woodbridge, Virginia 22192
Woodbridge, Virginia 22192
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
Aberdeen, Washington 98520
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
Bellingham, Washington 98225
Contact:
Site Public Contact
360-788-8223
Site Public Contact
360-788-8223
Harrison HealthPartners Hematology and Oncology-Bremerton
Bremerton, Washington 98310
Bremerton, Washington 98310
Harrison Medical Center
Bremerton, Washington 98310
Bremerton, Washington 98310
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
Centralia, Washington 98531
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
Edmonds, Washington 98026
Providence Regional Cancer Partnership
Everett, Washington 98201
Everett, Washington 98201
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
Issaquah, Washington 98029
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
Kennewick, Washington 99336
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
Lacey, Washington 98503
PeaceHealth Saint John Medical Center
Longview, Washington 98632
Longview, Washington 98632
Valley Medical Center
Renton, Washington 98055
Renton, Washington 98055
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
Seattle, Washington 98107
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
Seattle, Washington 98122-5711
Swedish Medical Center-First Hill
Seattle, Washington 98122
Seattle, Washington 98122
PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
Sedro-Woolley, Washington 98284
Providence Regional Cancer System-Shelton
Shelton, Washington 98584
Shelton, Washington 98584
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
Vancouver, Washington 98664
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
Walla Walla, Washington 99362
North Star Lodge Cancer Center at Yakima Valley Memorial Hospital
Yakima, Washington 98902
Yakima, Washington 98902
Providence Regional Cancer System-Yelm
Yelm, Washington 98597
Yelm, Washington 98597
United Hospital Center
Bridgeport, West Virginia 26330
Bridgeport, West Virginia 26330
WVUH-Berkely Medical Center
Martinsburg, West Virginia 25401
Martinsburg, West Virginia 25401
West Virginia University Healthcare
Morgantown, West Virginia 26506
Morgantown, West Virginia 26506
Camden Clark Medical Center
Parkersburg, West Virginia 26101
Parkersburg, West Virginia 26101
Princeton Community Hospital
Princeton, West Virginia 24740
Princeton, West Virginia 24740
Contact:
Site Public Contact
304-487-7515
Site Public Contact
304-487-7515
Wheeling Hospital/Schiffler Cancer Center
Wheeling, West Virginia 26003
Wheeling, West Virginia 26003
Contact:
Site Public Contact
304-243-6442
Site Public Contact
304-243-6442
ThedaCare Regional Cancer Center
Appleton, Wisconsin 54911
Appleton, Wisconsin 54911
Ascension Saint Elizabeth Hospital
Appleton, Wisconsin 54915
Appleton, Wisconsin 54915
Ascension Southeast Wisconsin Hospital - Elmbrook Campus
Brookfield, Wisconsin 53045
Brookfield, Wisconsin 53045
Ascension Calumet Hospital
Chilton, Wisconsin 53014
Chilton, Wisconsin 53014
Marshfield Clinic-Chippewa Center
Chippewa Falls, Wisconsin 54729
Chippewa Falls, Wisconsin 54729
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Mayo Clinic Health System-Eau Claire Clinic
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Saint Agnes Hospital/Agnesian Cancer Center
Fond Du Lac, Wisconsin 54935
Fond Du Lac, Wisconsin 54935
Contact:
Site Public Contact
800-494-2927
Site Public Contact
800-494-2927
Ascension Saint Francis - Reiman Cancer Center
Franklin, Wisconsin 53132
Franklin, Wisconsin 53132
Ascension Southeast Wisconsin Hospital - Franklin
Franklin, Wisconsin 53132
Franklin, Wisconsin 53132
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Green Bay, Wisconsin 54303
Marshfield Clinic - Ladysmith Center
Ladysmith, Wisconsin 54848
Ladysmith, Wisconsin 54848
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
Marshfield, Wisconsin 54449
Ascension Columbia Saint Mary's Hospital Ozaukee
Mequon, Wisconsin 53097
Mequon, Wisconsin 53097
Ascension Columbia Saint Mary's Hospital - Milwaukee
Milwaukee, Wisconsin 53211
Milwaukee, Wisconsin 53211
Ascension Saint Francis Hospital
Milwaukee, Wisconsin 53215
Milwaukee, Wisconsin 53215
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin 54548
Minocqua, Wisconsin 54548
ProHealth D N Greenwald Center
Mukwonago, Wisconsin 53149
Mukwonago, Wisconsin 53149
Cancer Center of Western Wisconsin
New Richmond, Wisconsin 54017
New Richmond, Wisconsin 54017
ProHealth Oconomowoc Memorial Hospital
Oconomowoc, Wisconsin 53066
Oconomowoc, Wisconsin 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Saint Vincent Hospital Cancer Center at Oconto Falls
Oconto Falls, Wisconsin 54154
Oconto Falls, Wisconsin 54154
Ascension Mercy Hospital
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Ascension All Saints Hospital
Racine, Wisconsin 53405
Racine, Wisconsin 53405
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
Rice Lake, Wisconsin 54868
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
Stevens Point, Wisconsin 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
Sturgeon Bay, Wisconsin 54235-1495
ProHealth Waukesha Memorial Hospital
Waukesha, Wisconsin 53188
Waukesha, Wisconsin 53188
Contact:
Site Public Contact
262-928-7632
Site Public Contact
262-928-7632
UW Cancer Center at ProHealth Care
Waukesha, Wisconsin 53188
Waukesha, Wisconsin 53188
Marshfield Clinic-Wausau Center
Wausau, Wisconsin 54401
Wausau, Wisconsin 54401
Ascension Medical Group Southeast Wisconsin - Mayfair Road
Wauwatosa, Wisconsin 53226
Wauwatosa, Wisconsin 53226
Marshfield Medical Center - Weston
Weston, Wisconsin 54476
Weston, Wisconsin 54476
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids, Wisconsin 54494
Wisconsin Rapids, Wisconsin 54494
Billings Clinic-Cody
Cody, Wyoming 82414
Cody, Wyoming 82414
Welch Cancer Center
Sheridan, Wyoming 82801
Sheridan, Wyoming 82801
More Details
- NCT ID
- NCT04137107
- Status
- Recruiting
- Sponsor
- Alliance for Clinical Trials in Oncology
Detailed Description
The primary and secondary objectives of the study: PRIMARY OBJECTIVES: I. To determine the dosage of duloxetine hydrochloride (duloxetine) (30 mg or 60 mg daily) that appears most promising in preventing oxaliplatin-induced peripheral neuropathy (OIPN). (Phase II) II. To demonstrate that the most promising dosage of duloxetine identified in the Phase II component is more effective than placebo at preventing OIPN sensory symptoms. (Phase III) III. To demonstrate that the most promising dosage of duloxetine identified in the Phase II component is more effective than placebo at preventing oxaliplatin-induced chronic neuropathic pain. (Phase III) SECONDARY OBJECTIVES: I. To characterize toxicity in each arm, including duloxetine side effects of nausea, dry mouth, dizziness, somnolence, fatigue, and insomnia using Common Terminology Criteria for Adverse Events (CTCAE) version (v) 5.0. (Phase II) II. To compare the serially measured OIPN total sensory neuropathy scores calculated from the six individual Quality of Life Questionnaire - Chemotherapy-Induced Peripheral Neuropathy 20 (QLQ-CIPN20) questions that quantify numbness, tingling, and pain in the fingers (or hands) and toes (or feet), measured on day 1 of each cycle of oxaliplatin treatment and at 1 month post-oxaliplatin treatment between the most promising dosage of duloxetine identified in the Phase II component and placebo. (Phase III) III. To compare the serially measured Brief Pain Inventory Short Form (BPI-SF) patient-reported on the average pain scores, measured on day 1 of each cycle of oxaliplatin treatment and at 1 month post-oxaliplatin treatment between the most promising dosage of duloxetine identified in the Phase II component and placebo. IV. To characterize toxicity in each arm, including duloxetine side effects of nausea, dry mouth, dizziness, somnolence, fatigue, and insomnia using the CTCAE v 5.0. (Phase III) OUTLINE: PHASE II: Patients are randomized to 1 of 3 arms. ARM I: Patients in Phase II receive duloxetine hydrochloride 30 mg (1 duloxetine capsule) orally (PO) once daily (QD) during week 1, duloxetine hydrochloride 30 mg (1 duloxetine capsule) PO QD and placebo (1 placebo capsule) PO QD during weeks 2-16, followed by duloxetine hydrochloride 30 mg (1 duloxetine capsule) PO QD during week 17 in the absence of unacceptable toxicity. ARM II: Patients in Phase II receive duloxetine hydrochloride 30 mg (1 duloxetine capsule) orally (PO) once daily (QD) during week 1, duloxetine hydrochloride 60 mg (2 duloxetine capsules) PO QD during weeks 2-16, followed by duloxetine hydrochloride 30 mg (1 duloxetine capsule) PO QD during week 17 in the absence of unacceptable toxicity. ARM III: Patients in Phase II receive placebo (1 placebo capsule) orally (PO) once daily (QD) during week 1, placebo (2 placebo capsules) PO QD weeks 2-16, followed by placebo (1 placebo capsule) PO QD during week 17 in the absence of unacceptable toxicity. PHASE III: Patients are randomized to 1 of 2 arms. ARM I: Patients in Phase III receive most promising dose of duloxetine hydrochloride from Phase II PO QD in the absence of unacceptable toxicity. ARM II: Patients in Phase III receive placebo PO QD in the absence of unacceptable toxicity. NOTE: Patients in all arms receive standard of care oxaliplatin during weeks 1-12. After completion of study, patients are followed up at 30 days and at 3, 6, 12, and 18 months after last oxaliplatin treatment.