Comparing Two Methods to Follow Patients With Pancreatic Cysts
Purpose
The purpose of this study is to compare the two approaches for monitoring pancreatic cysts. The study doctors want to compare more frequent monitoring vs less frequent monitoring in order to learn which monitoring method leads to better outcome for patients with pancreatic cysts.
Condition
- Pancreatic Carcinoma
Eligibility
- Eligible Ages
- Between 50 Years and 75 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Criteria
- Patient must be ≥ 50 years and ≤ 75 years of age.
- Patient must not have acute pancreatitis or a history of chronic pancreatitis.
- Patient must have received a CT, MRI, or EUS within 6 months prior to randomization
that revealed one or more ≥ 1 cm pancreatic cyst (s).
- Patients of childbearing potential must not be known to be pregnant.
- Patient must not have a prior diagnosis of pancreatic malignancy of any type.
- Patient must not have a history of pancreatic resection.
- Patients with only pancreatic lesions without malignant risk (pancreatic pseudocyst
or classic serous cystic lesion) are not eligible.
- Patient must not have a family history of pancreatic adenocarcinoma in one or more
first degree relatives(biological parents, full siblings or children).
- Patient must not have pancreatic cyst morphology that would prompt immediate
surgical consideration (enhancing mural nodule, solid component in cyst, pancreatic
duct ≥10mm, cyst causing obstructive jaundice).
- Patient must not have a comorbid illness that precludes pancreatic cyst resection.
- Patient must not be participating in any form of pancreatic cyst surveillance.
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Supportive Care
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Arm I (low intensity surveillance) |
Patients undergo MRI or CT at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative EUS, repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years. |
|
|
Experimental Arm II (high intensity surveillance) |
Patients undergo MRI or CT. Patients with 1-2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with 2-3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst > 3 cm undergo EUS within 6 months, and if EUS is negative, patients undergo alternate MRI or CT with EUS every 3-6 months. |
|
Recruiting Locations
University of Alabama at Birmingham Cancer Center
Birmingham, Alabama 35233
Birmingham, Alabama 35233
University of South Alabama Mitchell Cancer Institute
Mobile, Alabama 36688
Mobile, Alabama 36688
Anchorage Associates in Radiation Medicine
Anchorage, Alaska 98508
Anchorage, Alaska 98508
Alaska Breast Care and Surgery LLC
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Alaska Oncology and Hematology LLC
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Alaska Women's Cancer Care
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Katmai Oncology Group
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Providence Alaska Medical Center
Anchorage, Alaska 99508
Anchorage, Alaska 99508
Mayo Clinic Hospital in Arizona
Phoenix, Arizona 85054
Phoenix, Arizona 85054
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855-776-0015
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855-776-0015
Mayo Clinic in Arizona
Scottsdale, Arizona 85259
Scottsdale, Arizona 85259
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Baptist Health Medical Center - Little Rock
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
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501-202-4715
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501-202-4715
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
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501-686-8274
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501-686-8274
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank, California 91505
Burbank, California 91505
UC San Diego Moores Cancer Center
La Jolla, California 92093
La Jolla, California 92093
Loma Linda University Medical Center
Loma Linda, California 92354
Loma Linda, California 92354
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909-558-4050
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909-558-4050
UCLA / Jonsson Comprehensive Cancer Center
Los Angeles, California 90095
Los Angeles, California 90095
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888-798-0719
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888-798-0719
University of California Davis Comprehensive Cancer Center
Sacramento, California 95817
Sacramento, California 95817
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916-734-3089
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916-734-3089
UCSF Medical Center-Mount Zion
San Francisco, California 94115
San Francisco, California 94115
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877-827-3222
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877-827-3222
UCSF Medical Center-Parnassus
San Francisco, California 94143
San Francisco, California 94143
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877-827-3222
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877-827-3222
UCSF Medical Center-Mission Bay
San Francisco, California 94158
San Francisco, California 94158
Smilow Cancer Hospital-Derby Care Center
Derby, Connecticut 06418
Derby, Connecticut 06418
Smilow Cancer Hospital Care Center-Fairfield
Fairfield, Connecticut 06824
Fairfield, Connecticut 06824
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury, Connecticut 06033
Glastonbury, Connecticut 06033
Smilow Cancer Hospital Care Center at Greenwich
Greenwich, Connecticut 06830
Greenwich, Connecticut 06830
Smilow Cancer Hospital Care Center - Guilford
Guilford, Connecticut 06437
Guilford, Connecticut 06437
Smilow Cancer Hospital-Hamden Care Center
Hamden, Connecticut 06518
Hamden, Connecticut 06518
Smilow Cancer Hospital Care Center at Saint Francis
Hartford, Connecticut 06105
Hartford, Connecticut 06105
Smilow Cancer Center/Yale-New Haven Hospital
New Haven, Connecticut 06510
New Haven, Connecticut 06510
Yale-New Haven Hospital Saint Raphael Campus
New Haven, Connecticut 06511
New Haven, Connecticut 06511
Yale University
New Haven, Connecticut 06520
New Haven, Connecticut 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven, Connecticut 06473
North Haven, Connecticut 06473
Smilow Cancer Hospital-Orange Care Center
Orange, Connecticut 06477
Orange, Connecticut 06477
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Torrington, Connecticut 06790
Torrington, Connecticut 06790
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Trumbull, Connecticut 06611
Trumbull, Connecticut 06611
Smilow Cancer Hospital-Waterbury Care Center
Waterbury, Connecticut 06708
Waterbury, Connecticut 06708
Smilow Cancer Hospital Care Center - Waterford
Waterford, Connecticut 06385
Waterford, Connecticut 06385
Veterans Affairs Connecticut Healthcare System-West Haven Campus
West Haven, Connecticut 06516
West Haven, Connecticut 06516
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203-937-3421
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203-937-3421
Beebe Medical Center
Lewes, Delaware 19958
Lewes, Delaware 19958
Beebe South Coastal Health Campus
Millville, Delaware 19967
Millville, Delaware 19967
Helen F Graham Cancer Center
Newark, Delaware 19713
Newark, Delaware 19713
Medical Oncology Hematology Consultants PA
Newark, Delaware 19713
Newark, Delaware 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
Newark, Delaware 19718
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Rehoboth Beach, Delaware 19971
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Wilmington, Delaware 19801
Wilmington, Delaware 19801
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Washington D.C., District of Columbia 20007
Washington D.C., District of Columbia 20007
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Holy Cross Hospital
Fort Lauderdale, Florida 33308
Fort Lauderdale, Florida 33308
Regional Cancer Center-Lee Memorial Health System
Fort Myers, Florida 33905
Fort Myers, Florida 33905
Mayo Clinic in Florida
Jacksonville, Florida 32224-9980
Jacksonville, Florida 32224-9980
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Emory University Hospital Midtown
Atlanta, Georgia 30308
Atlanta, Georgia 30308
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Atlanta, Georgia 30322
Atlanta, Georgia 30322
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Emory Saint Joseph's Hospital
Atlanta, Georgia 30342
Atlanta, Georgia 30342
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Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Boise, Idaho 83706
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Boise, Idaho 83712
Boise, Idaho 83712
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Caldwell, Idaho 83605
Caldwell, Idaho 83605
Saint Luke's Cancer Institute - Fruitland
Fruitland, Idaho 83619
Fruitland, Idaho 83619
Idaho Urologic Institute-Meridian
Meridian, Idaho 83642
Meridian, Idaho 83642
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Meridian, Idaho 83642
Meridian, Idaho 83642
Saint Alphonsus Cancer Care Center-Nampa
Nampa, Idaho 83687
Nampa, Idaho 83687
Saint Luke's Cancer Institute - Nampa
Nampa, Idaho 83687
Nampa, Idaho 83687
Saint Luke's Cancer Institute - Twin Falls
Twin Falls, Idaho 83301
Twin Falls, Idaho 83301
Advocate Outpatient Center - Aurora
Aurora, Illinois 60506
Aurora, Illinois 60506
Advocate Good Shepherd Hospital
Barrington, Illinois 60010
Barrington, Illinois 60010
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Bloomington, Illinois 61704
Bloomington, Illinois 61704
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Bloomington, Illinois 61704
Bloomington, Illinois 61704
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Canton, Illinois 61520
Canton, Illinois 61520
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Carbondale, Illinois 62902
Carbondale, Illinois 62902
SIH Cancer Institute
Carterville, Illinois 62918
Carterville, Illinois 62918
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Carthage, Illinois 62321
Carthage, Illinois 62321
Centralia Oncology Clinic
Centralia, Illinois 62801
Centralia, Illinois 62801
Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
Chicago, Illinois 60657
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773-296-5360
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773-296-5360
AMG Crystal Lake - Oncology
Crystal Lake, Illinois 60014
Crystal Lake, Illinois 60014
Carle at The Riverfront
Danville, Illinois 61832
Danville, Illinois 61832
Cancer Care Specialists of Illinois - Decatur
Decatur, Illinois 62526
Decatur, Illinois 62526
Decatur Memorial Hospital
Decatur, Illinois 62526
Decatur, Illinois 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois 60115
DeKalb, Illinois 60115
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Dixon, Illinois 61021
Dixon, Illinois 61021
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815-285-7800
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Advocate Good Samaritan Hospital
Downers Grove, Illinois 60515
Downers Grove, Illinois 60515
Carle Physician Group-Effingham
Effingham, Illinois 62401
Effingham, Illinois 62401
Crossroads Cancer Center
Effingham, Illinois 62401
Effingham, Illinois 62401
Advocate Sherman Hospital
Elgin, Illinois 60123
Elgin, Illinois 60123
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847-429-2907
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Elmhurst Memorial Hospital
Elmhurst, Illinois 60126
Elmhurst, Illinois 60126
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Eureka, Illinois 61530
Eureka, Illinois 61530
Illinois CancerCare-Galesburg
Galesburg, Illinois 61401
Galesburg, Illinois 61401
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois 60134
Geneva, Illinois 60134
Advocate South Suburban Hospital
Hazel Crest, Illinois 60429
Hazel Crest, Illinois 60429
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708-799-9995
Site Public Contact
708-799-9995
Illinois CancerCare-Kewanee Clinic
Kewanee, Illinois 61443
Kewanee, Illinois 61443
AMG Libertyville - Oncology
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Condell Memorial Hospital
Libertyville, Illinois 60048
Libertyville, Illinois 60048
Illinois CancerCare-Macomb
Macomb, Illinois 61455
Macomb, Illinois 61455
Carle Physician Group-Mattoon/Charleston
Mattoon, Illinois 61938
Mattoon, Illinois 61938
Edward Hospital/Cancer Center
Naperville, Illinois 60540
Naperville, Illinois 60540
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630-646-6075
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630-646-6075
Carle BroMenn Medical Center
Normal, Illinois 61761
Normal, Illinois 61761
Carle Cancer Institute Normal
Normal, Illinois 61761
Normal, Illinois 61761
Cancer Care Center of O'Fallon
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
HSHS Saint Elizabeth's Hospital
O'Fallon, Illinois 62269
O'Fallon, Illinois 62269
Northwestern Medicine Oak Brook
Oak Brook, Illinois 60523
Oak Brook, Illinois 60523
Advocate Christ Medical Center
Oak Lawn, Illinois 60453-2699
Oak Lawn, Illinois 60453-2699
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800-323-8622
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800-323-8622
Northwestern Medicine Orland Park
Orland Park, Illinois 60462
Orland Park, Illinois 60462
Illinois CancerCare-Ottawa Clinic
Ottawa, Illinois 61350
Ottawa, Illinois 61350
Advocate Lutheran General Hospital
Park Ridge, Illinois 60068
Park Ridge, Illinois 60068
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847-384-3621
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847-384-3621
Illinois CancerCare-Pekin
Pekin, Illinois 61554
Pekin, Illinois 61554
Illinois CancerCare-Peoria
Peoria, Illinois 61615
Peoria, Illinois 61615
Methodist Medical Center of Illinois
Peoria, Illinois 61636
Peoria, Illinois 61636
Illinois CancerCare-Peru
Peru, Illinois 61354
Peru, Illinois 61354
Valley Radiation Oncology
Peru, Illinois 61354
Peru, Illinois 61354
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815-664-4141
Site Public Contact
815-664-4141
Edward Hospital/Cancer Center?Plainfield
Plainfield, Illinois 60585
Plainfield, Illinois 60585
Illinois CancerCare-Princeton
Princeton, Illinois 61356
Princeton, Illinois 61356
Southern Illinois University School of Medicine
Springfield, Illinois 62702
Springfield, Illinois 62702
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217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield, Illinois 62702
Springfield, Illinois 62702
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800-444-7541
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800-444-7541
Springfield Memorial Hospital
Springfield, Illinois 62781
Springfield, Illinois 62781
Carle Cancer Center
Urbana, Illinois 61801
Urbana, Illinois 61801
The Carle Foundation Hospital
Urbana, Illinois 61801
Urbana, Illinois 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois 60555
Warrenville, Illinois 60555
Illinois CancerCare - Washington
Washington, Illinois 61571
Washington, Illinois 61571
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny, Iowa 50023
Ankeny, Iowa 50023
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515-241-3305
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515-241-3305
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Clive, Iowa 50325
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515-241-3305
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515-241-3305
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive, Iowa 50325
Clive, Iowa 50325
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515-241-3305
Site Public Contact
515-241-3305
Greater Regional Medical Center
Creston, Iowa 50801
Creston, Iowa 50801
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515-241-3305
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515-241-3305
Iowa Methodist Medical Center
Des Moines, Iowa 50309
Des Moines, Iowa 50309
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515-241-6727
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515-241-6727
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines, Iowa 50309
Des Moines, Iowa 50309
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515-241-3305
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515-241-3305
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Des Moines, Iowa 50314
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515-241-3305
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515-241-3305
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines, Iowa 50314
Des Moines, Iowa 50314
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515-241-3305
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515-241-3305
University of Iowa/Holden Comprehensive Cancer Center
Iowa City, Iowa 52242
Iowa City, Iowa 52242
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800-237-1225
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800-237-1225
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee, Iowa 50263
Waukee, Iowa 50263
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515-241-3305
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515-241-3305
Mercy Medical Center-West Lakes
West Des Moines, Iowa 50266
West Des Moines, Iowa 50266
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515-241-3305
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515-241-3305
LSU Health Baton Rouge-North Clinic
Baton Rouge, Louisiana 70805
Baton Rouge, Louisiana 70805
Our Lady of the Lake Physician Group
Baton Rouge, Louisiana 70808
Baton Rouge, Louisiana 70808
Our Lady of The Lake
Baton Rouge, Louisiana 70808
Baton Rouge, Louisiana 70808
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225-765-7659
Site Public Contact
225-765-7659
Christiana Care - Union Hospital
Elkton, Maryland 21921
Elkton, Maryland 21921
MyMichigan Medical Center Gratiot
Alma, Michigan 48801
Alma, Michigan 48801
MyMichigan Medical Center Alpena
Alpena, Michigan 49707
Alpena, Michigan 49707
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor, Michigan 48106
Ann Arbor, Michigan 48106
University of Michigan Rogel Cancer Center
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
Bronson Battle Creek
Battle Creek, Michigan 49017
Battle Creek, Michigan 49017
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Trinity Health Medical Center - Brighton
Brighton, Michigan 48114
Brighton, Michigan 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton, Michigan 48188
Canton, Michigan 48188
Trinity Health Medical Center - Canton
Canton, Michigan 48188
Canton, Michigan 48188
Chelsea Hospital
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea, Michigan 48118
Chelsea, Michigan 48118
Hematology Oncology Consultants-Clarkston
Clarkston, Michigan 48346
Clarkston, Michigan 48346
Newland Medical Associates-Clarkston
Clarkston, Michigan 48346
Clarkston, Michigan 48346
Corewell Health Dearborn Hospital
Dearborn, Michigan 48124
Dearborn, Michigan 48124
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248-551-7695
Site Public Contact
248-551-7695
Henry Ford Health Saint John Hospital
Detroit, Michigan 48236
Detroit, Michigan 48236
Henry Ford River District Hospital
East China Township, Michigan 48054
East China Township, Michigan 48054
Corewell Health Farmington Hills Hospital
Farmington Hills, Michigan 48336
Farmington Hills, Michigan 48336
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248-551-7695
Site Public Contact
248-551-7695
Cancer Hematology Centers - Flint
Flint, Michigan 48503
Flint, Michigan 48503
Genesee Hematology Oncology PC
Flint, Michigan 48503
Flint, Michigan 48503
Genesys Hurley Cancer Institute
Flint, Michigan 48503
Flint, Michigan 48503
Hurley Medical Center
Flint, Michigan 48503
Flint, Michigan 48503
MyMichigan Medical Center Gladwin
Gladwin, Michigan 48624
Gladwin, Michigan 48624
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Trinity Health Grand Rapids Hospital
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Henry Ford Saint John Hospital - Academic
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Henry Ford Saint John Hospital - Breast
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods, Michigan 48236
Grosse Pointe Woods, Michigan 48236
Bronson Methodist Hospital
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
West Michigan Cancer Center
Kalamazoo, Michigan 49007
Kalamazoo, Michigan 49007
Beacon Kalamazoo Cancer Center
Kalamazoo, Michigan 49009
Kalamazoo, Michigan 49009
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574-647-7370
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574-647-7370
Beacon Kalamazoo
Kalamazoo, Michigan 49048
Kalamazoo, Michigan 49048
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574-647-7370
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574-647-7370
University of Michigan Health - Sparrow Lansing
Lansing, Michigan 48912
Lansing, Michigan 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia, Michigan 48154
Livonia, Michigan 48154
Henry Ford Saint John Hospital - Macomb Medical
Macomb, Michigan 48044
Macomb, Michigan 48044
Henry Ford Warren Hospital - Breast Macomb
Macomb, Michigan 48044
Macomb, Michigan 48044
MyMichigan Medical Center Midland
Midland, Michigan 48670
Midland, Michigan 48670
MyMichigan Medical Center Mount Pleasant
Mount Pleasant, Michigan 48858
Mount Pleasant, Michigan 48858
Trinity Health Muskegon Hospital
Muskegon, Michigan 49444
Muskegon, Michigan 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles, Michigan 49120
Niles, Michigan 49120
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616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores, Michigan 49444
Norton Shores, Michigan 49444
Hope Cancer Center
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Michigan Healthcare Professionals Pontiac
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Newland Medical Associates-Pontiac
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac, Michigan 48341
Pontiac, Michigan 48341
Corewell Health Reed City Hospital
Reed City, Michigan 49677
Reed City, Michigan 49677
Oakland Colon Rectal Associates
Royal Oak, Michigan 48067
Royal Oak, Michigan 48067
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248-551-7695
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248-551-7695
Cancer Care Associates PC
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
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248-551-7695
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248-551-7695
Comprehensive Medical Center PLLC
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
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248-551-7695
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248-551-7695
Corewell Health William Beaumont University Hospital
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
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248-551-7695
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248-551-7695
Hematology Oncology Consultants PC-Royal Oak
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
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248-551-7695
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248-551-7695
Oakland Medical Group
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
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248-551-7695
MyMichigan Medical Center Saginaw
Saginaw, Michigan 48601
Saginaw, Michigan 48601
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
Corewell Health Lakeland Hospitals - Saint Joseph Hospital
Saint Joseph, Michigan 49085
Saint Joseph, Michigan 49085
MyMichigan Medical Center Tawas
Tawas City, Michigan 48764
Tawas City, Michigan 48764
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
Michigan Institute of Urology-Town Center
Troy, Michigan 48084
Troy, Michigan 48084
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248-551-7695
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248-551-7695
Corewell Health Beaumont Troy Hospital
Troy, Michigan 48085
Troy, Michigan 48085
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248-551-7695
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248-551-7695
Hematology Oncology Consultants PC-Troy
Troy, Michigan 48098
Troy, Michigan 48098
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248-551-7695
Site Public Contact
248-551-7695
Henry Ford Health Warren Hospital
Warren, Michigan 48093
Warren, Michigan 48093
Henry Ford Madison Heights Hospital - Breast
Warren, Michigan 48093
Warren, Michigan 48093
Henry Ford Warren Hospital - GLCMS
Warren, Michigan 48093
Warren, Michigan 48093
University of Michigan Health - West
Wyoming, Michigan 49519
Wyoming, Michigan 49519
Huron Gastroenterology PC
Ypsilanti, Michigan 48106
Ypsilanti, Michigan 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti, Michigan 48197
Ypsilanti, Michigan 48197
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
Mayo Clinic in Rochester
Rochester, Minnesota 55905
Rochester, Minnesota 55905
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855-776-0015
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855-776-0015
Sanford Thief River Falls Medical Center
Thief River Falls, Minnesota 56701
Thief River Falls, Minnesota 56701
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605-312-3320
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605-312-3320
Sanford Cancer Center Worthington
Worthington, Minnesota 56187
Worthington, Minnesota 56187
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605-312-3320
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605-312-3320
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
Parkland Health Center - Farmington
Farmington, Missouri 63640
Farmington, Missouri 63640
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314-996-5569
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314-996-5569
Sainte Genevieve County Memorial Hospital
Sainte Genevieve, Missouri 63670
Sainte Genevieve, Missouri 63670
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314-996-5569
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314-996-5569
Washington University School of Medicine
St Louis, Missouri 63110
St Louis, Missouri 63110
Missouri Baptist Medical Center
St Louis, Missouri 63131
St Louis, Missouri 63131
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314-996-5569
Site Public Contact
314-996-5569
Missouri Baptist Sullivan Hospital
Sullivan, Missouri 63080
Sullivan, Missouri 63080
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314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills, Missouri 63127
Sunset Hills, Missouri 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Saint Patrick Hospital - Community Hospital
Missoula, Montana 59802
Missoula, Montana 59802
CentraState Medical Center
Freehold, New Jersey 07728
Freehold, New Jersey 07728
Contact:
Site Public Contact
732-303-5047
Site Public Contact
732-303-5047
Morristown Medical Center
Morristown, New Jersey 07960
Morristown, New Jersey 07960
Contact:
Site Public Contact
973-971-5900
Site Public Contact
973-971-5900
Saint Peter's University Hospital
New Brunswick, New Jersey 08901
New Brunswick, New Jersey 08901
Penn Medicine Princeton Health
Plainsboro, New Jersey 08536
Plainsboro, New Jersey 08536
Overlook Hospital
Summit, New Jersey 07902
Summit, New Jersey 07902
Contact:
Site Public Contact
908-522-2043
Site Public Contact
908-522-2043
University of New Mexico Cancer Center
Albuquerque, New Mexico 87106
Albuquerque, New Mexico 87106
Roswell Park Cancer Institute
Buffalo, New York 14263
Buffalo, New York 14263
Glens Falls Hospital
Glens Falls, New York 12801
Glens Falls, New York 12801
Contact:
Site Public Contact
518-926-6700
Site Public Contact
518-926-6700
Northwell Health/Center for Advanced Medicine
Lake Success, New York 11042
Lake Success, New York 11042
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
Lenox Hill Hospital
New York, New York 10075
New York, New York 10075
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
Stony Brook University Medical Center
Stony Brook, New York 11794
Stony Brook, New York 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
Montefiore Medical Center-Einstein Campus
The Bronx, New York 10461
The Bronx, New York 10461
Montefiore Medical Center-Weiler Hospital
The Bronx, New York 10461
The Bronx, New York 10461
Montefiore Medical Center - Moses Campus
The Bronx, New York 10467
The Bronx, New York 10467
UNC Lineberger Comprehensive Cancer Center
Chapel Hill, North Carolina 27599
Chapel Hill, North Carolina 27599
Durham VA Medical Center
Durham, North Carolina 27705
Durham, North Carolina 27705
East Carolina University
Greenville, North Carolina 27834
Greenville, North Carolina 27834
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
Sanford South University Medical Center
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Contact:
Site Public Contact
701-234-6161
Site Public Contact
701-234-6161
Southpointe-Sanford Medical Center Fargo
Fargo, North Dakota 58103
Fargo, North Dakota 58103
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Sanford Medical Center Fargo
Fargo, North Dakota 58104
Fargo, North Dakota 58104
Contact:
Site Public Contact
800-437-4010
Site Public Contact
800-437-4010
Sanford Broadway Medical Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Sanford Roger Maris Cancer Center
Fargo, North Dakota 58122
Fargo, North Dakota 58122
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Columbus, Ohio 43210
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Saint Alphonsus Cancer Care Center-Baker City
Baker City, Oregon 97814
Baker City, Oregon 97814
Saint Charles Health System
Bend, Oregon 97701
Bend, Oregon 97701
Clackamas Radiation Oncology Center
Clackamas, Oregon 97015
Clackamas, Oregon 97015
Bay Area Hospital
Coos Bay, Oregon 97420
Coos Bay, Oregon 97420
Providence Hood River Memorial Hospital
Hood River, Oregon 97031
Hood River, Oregon 97031
Providence Newberg Medical Center
Newberg, Oregon 97132
Newberg, Oregon 97132
Saint Alphonsus Cancer Care Center-Ontario
Ontario, Oregon 97914
Ontario, Oregon 97914
Providence Willamette Falls Medical Center
Oregon City, Oregon 97045
Oregon City, Oregon 97045
Providence Portland Medical Center
Portland, Oregon 97213
Portland, Oregon 97213
Providence Saint Vincent Medical Center
Portland, Oregon 97225
Portland, Oregon 97225
Oregon Health and Science University
Portland, Oregon 97239
Portland, Oregon 97239
Saint Charles Health System-Redmond
Redmond, Oregon 97756
Redmond, Oregon 97756
Contact:
Site Public Contact
541-706-2909
Site Public Contact
541-706-2909
Lehigh Valley Hospital-Cedar Crest
Allentown, Pennsylvania 18103
Allentown, Pennsylvania 18103
Saint Luke's Cancer Center - Allentown
Allentown, Pennsylvania 18104
Allentown, Pennsylvania 18104
Contact:
Site Public Contact
610-776-4714
Site Public Contact
610-776-4714
Saint Luke's University Hospital-Bethlehem Campus
Bethlehem, Pennsylvania 18015
Bethlehem, Pennsylvania 18015
Contact:
Site Public Contact
484-503-4151
Site Public Contact
484-503-4151
Lehigh Valley Hospital - Muhlenberg
Bethlehem, Pennsylvania 18017
Bethlehem, Pennsylvania 18017
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010
Bryn Mawr, Pennsylvania 19010
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
Chadds Ford, Pennsylvania 19317
Geisinger Medical Center
Danville, Pennsylvania 17822
Danville, Pennsylvania 17822
Pocono Medical Center
East Stroudsburg, Pennsylvania 18301
East Stroudsburg, Pennsylvania 18301
Saint Luke's Hospital-Anderson Campus
Easton, Pennsylvania 18045
Easton, Pennsylvania 18045
Lehigh Valley Hospital-Hazleton
Hazleton, Pennsylvania 18201
Hazleton, Pennsylvania 18201
Riddle Memorial Hospital
Media, Pennsylvania 19063
Media, Pennsylvania 19063
Paoli Memorial Hospital
Paoli, Pennsylvania 19301
Paoli, Pennsylvania 19301
University of Pennsylvania/Abramson Cancer Center
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
Fox Chase Cancer Center
Philadelphia, Pennsylvania 19111
Philadelphia, Pennsylvania 19111
Contact:
Site Public Contact
215-728-4790
Site Public Contact
215-728-4790
Saint Luke's Hospital - Upper Bucks Campus
Quakertown, Pennsylvania 18951
Quakertown, Pennsylvania 18951
Contact:
Site Public Contact
610-776-4714
Site Public Contact
610-776-4714
Saint Luke's Hospital - Monroe Campus
Stroudsburg, Pennsylvania 18360
Stroudsburg, Pennsylvania 18360
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania 18711
Wilkes-Barre, Pennsylvania 18711
Lankenau Medical Center
Wynnewood, Pennsylvania 19096
Wynnewood, Pennsylvania 19096
Smilow Cancer Hospital Care Center - Westerly
Westerly, Rhode Island 02891
Westerly, Rhode Island 02891
Roper Hospital
Charleston, South Carolina 29401
Charleston, South Carolina 29401
Bon Secours Saint Francis Hospital
Charleston, South Carolina 29414
Charleston, South Carolina 29414
Prisma Health Richland Hospital
Columbia, South Carolina 29203
Columbia, South Carolina 29203
Prisma Health Greenville Memorial Hospital
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Sanford Cancer Center Oncology Clinic
Sioux Falls, South Dakota 57104
Sioux Falls, South Dakota 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Sioux Falls, South Dakota 57117-5134
University of Tennessee - Knoxville
Knoxville, Tennessee 37920
Knoxville, Tennessee 37920
Contact:
Site Public Contact
865-544-9773
Site Public Contact
865-544-9773
Vanderbilt University/Ingram Cancer Center
Nashville, Tennessee 37232
Nashville, Tennessee 37232
Contact:
Site Public Contact
800-811-8480
Site Public Contact
800-811-8480
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
Dallas, Texas 75390
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston, Texas 77030
Houston, Texas 77030
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
Salt Lake City, Utah 84112
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners, Vermont 05602
Berlin Corners, Vermont 05602
Contact:
Site Public Contact
802-225-5400
Site Public Contact
802-225-5400
University of Vermont Medical Center
Burlington, Vermont 05401
Burlington, Vermont 05401
University of Vermont and State Agricultural College
Burlington, Vermont 05405
Burlington, Vermont 05405
Inova Alexandria Hospital
Alexandria, Virginia 22304
Alexandria, Virginia 22304
University of Virginia Cancer Center
Charlottesville, Virginia 22908
Charlottesville, Virginia 22908
Inova Schar Cancer Institute
Fairfax, Virginia 22031
Fairfax, Virginia 22031
Inova Fair Oaks Hospital
Fairfax, Virginia 22033
Fairfax, Virginia 22033
Inova Fairfax Hospital
Falls Church, Virginia 22042
Falls Church, Virginia 22042
Inova Loudoun Hospital
Leesburg, Virginia 20176
Leesburg, Virginia 20176
Sentara Norfolk General Hospital
Norfolk, Virginia 23507
Norfolk, Virginia 23507
Contact:
Site Public Contact
757-388-2406
Site Public Contact
757-388-2406
VCU Massey Cancer Center at Stony Point
Richmond, Virginia 23235
Richmond, Virginia 23235
VCU Massey Comprehensive Cancer Center
Richmond, Virginia 23298
Richmond, Virginia 23298
Valley Health / Winchester Medical Center
Winchester, Virginia 22601
Winchester, Virginia 22601
Contact:
Site Public Contact
540-536-7820
Site Public Contact
540-536-7820
Providence Regional Cancer System-Aberdeen
Aberdeen, Washington 98520
Aberdeen, Washington 98520
PeaceHealth Saint Joseph Medical Center
Bellingham, Washington 98225
Bellingham, Washington 98225
Providence Regional Cancer System-Centralia
Centralia, Washington 98531
Centralia, Washington 98531
Swedish Cancer Institute-Edmonds
Edmonds, Washington 98026
Edmonds, Washington 98026
Providence Regional Cancer Partnership
Everett, Washington 98201
Everett, Washington 98201
Swedish Cancer Institute-Issaquah
Issaquah, Washington 98029
Issaquah, Washington 98029
Kadlec Clinic Hematology and Oncology
Kennewick, Washington 99336
Kennewick, Washington 99336
Providence Regional Cancer System-Lacey
Lacey, Washington 98503
Lacey, Washington 98503
PeaceHealth Saint John Medical Center
Longview, Washington 98632
Longview, Washington 98632
Skagit Regional Health Cancer Care Center
Mount Vernon, Washington 98274
Mount Vernon, Washington 98274
Swedish Medical Center-Ballard Campus
Seattle, Washington 98107
Seattle, Washington 98107
Swedish Medical Center-Cherry Hill
Seattle, Washington 98122-5711
Seattle, Washington 98122-5711
Swedish Medical Center-First Hill
Seattle, Washington 98122
Seattle, Washington 98122
PeaceHealth United General Medical Center
Sedro-Woolley, Washington 98284
Sedro-Woolley, Washington 98284
Cancer Care Northwest - Spokane South
Spokane, Washington 99202
Spokane, Washington 99202
Cancer Care Northwest-Valley
Spokane, Washington 99216
Spokane, Washington 99216
Cancer Care Northwest-North Spokane
Spokane, Washington 99218
Spokane, Washington 99218
PeaceHealth Southwest Medical Center
Vancouver, Washington 98664
Vancouver, Washington 98664
Providence Saint Mary Regional Cancer Center
Walla Walla, Washington 99362
Walla Walla, Washington 99362
West Virginia University Healthcare
Morgantown, West Virginia 26506
Morgantown, West Virginia 26506
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin 53105
Burlington, Wisconsin 53105
Aurora Saint Luke's South Shore
Cudahy, Wisconsin 53110
Cudahy, Wisconsin 53110
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Aurora Health Care Germantown Health Center
Germantown, Wisconsin 53022
Germantown, Wisconsin 53022
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Grafton, Wisconsin 53024
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Green Bay, Wisconsin 54311
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Kenosha, Wisconsin 53142
Gundersen Lutheran Medical Center
La Crosse, Wisconsin 54601
La Crosse, Wisconsin 54601
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison, Wisconsin 53718
Madison, Wisconsin 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison, Wisconsin 53792
Madison, Wisconsin 53792
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
Marinette, Wisconsin 54143
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
Marshfield, Wisconsin 54449
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin 53209
Milwaukee, Wisconsin 53209
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Milwaukee, Wisconsin 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Milwaukee, Wisconsin 53233
Marshfield Medical Center - Minocqua
Minocqua, Wisconsin 54548
Minocqua, Wisconsin 54548
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Aurora Cancer Care-Racine
Racine, Wisconsin 53406
Racine, Wisconsin 53406
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
Rice Lake, Wisconsin 54868
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Marshfield Medical Center-River Region at Stevens Point
Stevens Point, Wisconsin 54482
Stevens Point, Wisconsin 54482
Aurora Medical Center in Summit
Summit, Wisconsin 53066
Summit, Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Two Rivers, Wisconsin 54241
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin 53226
Wauwatosa, Wisconsin 53226
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
West Allis, Wisconsin 53227
Marshfield Medical Center - Weston
Weston, Wisconsin 54476
Weston, Wisconsin 54476
Cancer Center-Metro Medical Center Bayamon
Bayamón, Puerto Rico 00959-5060
Bayamón, Puerto Rico 00959-5060
Contact:
Site Public Contact
787-395-7085
Site Public Contact
787-395-7085
Puerto Rico Hematology Oncology Group
Bayamón, Puerto Rico 00961
Bayamón, Puerto Rico 00961
Contact:
Site Public Contact
787-780-2865
Site Public Contact
787-780-2865
Doctors Cancer Center
Manati, Puerto Rico 00674
Manati, Puerto Rico 00674
Contact:
Site Public Contact
787-621-4397
Site Public Contact
787-621-4397
San Juan Community Oncology Group
San Juan, Puerto Rico 00917
San Juan, Puerto Rico 00917
Contact:
Site Public Contact
787-274-3387
Site Public Contact
787-274-3387
Centro Comprensivo de Cancer de UPR
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
PROncology
San Juan, Puerto Rico 00927
San Juan, Puerto Rico 00927
San Juan City Hospital
San Juan, Puerto Rico 00936
San Juan, Puerto Rico 00936
Contact:
Site Public Contact
787-763-1296
Site Public Contact
787-763-1296
More Details
- NCT ID
- NCT04239573
- Status
- Recruiting
- Sponsor
- ECOG-ACRIN Cancer Research Group
Detailed Description
PRIMARY OBJECTIVES: I. To compare the rates of unfavorable clinical outcomes in the two arms. SECONDARY OBJECTIVES: I. To compare rates of major surgical morbidity and/or mortality between arms. II. To compare pancreatic cancer incidence and all-cause mortality across arms. III. Compare institutional (direct) costs. IV. Compare healthcare utilization of imaging, invasive testing, surgical, and other procedures across the two surveillance arms. V. Compare patient (out-of-pocket and other indirect) costs. VI. Describe diagnostic test and treatment pathways by arm. VII. Compare patient reports of quality of life (QOL), situational anxiety. VIII. Compare patient report of financial distress. IX. Compare rates of non-adherence by arm assignment. X. To evaluate and compare the predictive performance of known and future biomarkers for dysplasia or cancer. EXPLORATORY OBJECTIVE: I. To evaluate and compare the predictive accuracy of known and future radiomic markers for dysplasia and pancreatic cancer. OUTLINE: Patients are randomized to 1 of 2 arms. ARM A (LOW INTENSITY SURVEILLANCE): Patients undergo magnetic resonance imaging (MRI) or computed tomography (CT) at the beginning of the trial and again in 1 year. Following the first year, patients with no abnormalities repeat MRI or CT every 2 years. Patients with positive imaging features on MRI and CT at 1 or 2 years and with negative endoscopic ultrasound (EUS), repeat MRI or CT in 1 year. Patients with negative imaging repeat MRI or CT in 2 years. ARM B (HIGH INTENSITY SURVEILLANCE): Patients undergo MRI or CT. Patients with 1-2 cm cyst undergo MRI or CT every 6 months for 1 year, then every 12 months for 2 years, and then every 24 months thereafter. Patients with 2-3 cm cyst undergo EUS within 6 months, and if EUS is negative, patients repeat MRI or CT in 1 year. If second EUS is negative, patients undergo alternate MRI or CT and EUS every 12 months. Patients with cyst > 3 cm undergo EUS within 6 months, and if EUS is negative, patients undergo alternate MRI or CT with EUS every 3-6 months. After completion of imaging procedures, patients are followed up for 5 years from the date of registration .