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Purpose

This clinical trial evaluates how well two surgical procedures (bilateral salpingectomy and bilateral salpingo-oophorectomy) work in reducing the risk of ovarian cancer for individuals with BRCA1 mutations. Bilateral salpingectomy involves the surgical removal of fallopian tubes, and bilateral salpingo-oophorectomy involves the surgical removal of both the fallopian tubes and ovaries. This study may help doctors determine if the two surgical procedures are nearly the same for ovarian cancer risk reduction for women with BRCA1 mutations.

Condition

Eligibility

Eligible Ages
Between 35 Years and 50 Years
Eligible Sex
Female
Accepts Healthy Volunteers
No

Inclusion Criteria

  • Individuals 35-50 years of age, inclusive - Patients who will undergo risk-reducing salpingo-oophorectomy (RRSO) (for the BSO arm) and patients who have declined or elected to defer BSO after proper counselling to clearly explain the standard of care for BRCA1 mutation carriers and are undergoing salpingectomy (for the BLS arm with delayed oophorectomy arm). Concurrently planned hysterectomy with either arm is permitted - At least one intact ovary and fallopian tube is in situ at the time of counseling, consent, and registration. Prior hysterectomy is allowed provided it did not include bilateral salpingectomy. Prior tubal ligation is allowed if one ovary and fallopian tube (with fimbria not removed) are present - Positive Clinical Laboratory Improvement Act (CLIA)-approved test results for pathogenic or likely pathogenic germline BRCA1 mutation in the patient. Documentation of the result is required - Patients may be premenopausal or menopausal - Pelvic ultrasound (transvaginal imaging preferred, but transabdominal imaging is acceptable) and CA-125 within 180 days of registration - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry - Individuals who are currently pregnant or plan to become pregnant in the future through assisted reproductive technologies and who have received proper counseling are eligible. Individuals who are currently pregnant and plan bilateral salpingectomy at the time of a planned cesarean section are eligible. Patients must understand that they will not be able to become pregnant naturally in the future

Exclusion Criteria

  • Individuals with a history of any prior cancer who have received cytotoxic chemotherapy within the past 30 days or radiotherapy to abdomen or pelvis at any prior time. Endocrine therapy or maintenance ERBB2/HER2 targeted therapy is allowed. Maintenance immune checkpoint inhibitor therapy is allowed. Maintenance therapy with PARP in inhibitor is allowed. - Prior history of ovarian cancer, including low malignant potential neoplasms (LMP), primary peritoneal carcinoma, or fallopian tube carcinoma - Patients medically unfit for the planned surgical procedure - Patients with abnormal screening tests (pelvic ultrasound, CA-125) suspicious for occult or gross pelvic malignancy within the past 180 days - An abnormal pelvic ultrasound is defined as morphologic or structural variations suspicious for ovarian malignancy. Complex cystic lesions felt to represent a benign lesion are not exclusionary. Simple cysts of any size are not exclusionary - An abnormal CA-125 is defined as a level > 50U/ml in premenopausal individuals if they are not current users of oral contraceptives; an abnormal CA-125 is defined as a level > 40U/ml for premenopausal individuals who are current users of oral contraceptives (Skates 2011). An abnormal CA-125 is defined as a level > 35 U/ml in postmenopausal individuals

Study Design

Phase
N/A
Study Type
Interventional
Allocation
Non-Randomized
Intervention Model
Parallel Assignment
Intervention Model Description
This is a non-randomized prospective trial to determine if bilateral salpingectomy (BLS) is non-inferior to bilateral salpingo-oophorectomy (BSO) in terms ovarian, primary peritoneal, and fallopian tube cancer risk among gBRCA1m carriers between 35 and 50 years old. Individuals choose the treatment they want to receive in collaboration with their physician(s).
Primary Purpose
Prevention
Masking
None (Open Label)

Arm Groups

ArmDescriptionAssigned Intervention
Experimental
Group I (bilateral salpingectomy) 		Patients undergo bilateral salpingectomy. Patients may then undergo oophorectomy after initial surgery. Patients also undergo a pelvic or transvaginal ultrasound during screening and blood sample collection throughout the trial.
  • Procedure: Bilateral Salpingectomy
    Undergo bilateral salpingectomy
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Procedure: Transvaginal Ultrasound
    Undergo transvaginal ultrasound
    Other names:
    • transvaginal sonography
    • TVS
    • TVU
  • Procedure: Ultrasound Imaging
    Undergo pelvic ultrasound
    Other names:
    • 2-Dimensional Grayscale Ultrasound Imaging
    • 2-Dimensional Ultrasound Imaging
    • 2D-US
    • Ultrasonography
    • Ultrasound
    • Ultrasound Test
    • Ultrasound, Medical
    • US
Active Comparator
Group II (bilateral salpingo-oophorectomy) 		Patients undergo bilateral salpingo-oophorectomy. Patients also undergo a pelvic or transvaginal ultrasound during screening and blood sample collection throughout the trial.
  • Procedure: Bilateral Salpingectomy with Oophorectomy
    Undergo bilateral salpingo-oophorectomy
    Other names:
    • bilateral salpingo-oophorectomy
  • Procedure: Biospecimen Collection
    Undergo blood sample collection
    Other names:
    • Biological Sample Collection
    • Biospecimen Collected
    • Specimen Collection
  • Other: Quality-of-Life Assessment
    Ancillary studies
    Other names:
    • Quality of Life Assessment
  • Other: Questionnaire Administration
    Ancillary studies
  • Procedure: Transvaginal Ultrasound
    Undergo transvaginal ultrasound
    Other names:
    • transvaginal sonography
    • TVS
    • TVU
  • Procedure: Ultrasound Imaging
    Undergo pelvic ultrasound
    Other names:
    • 2-Dimensional Grayscale Ultrasound Imaging
    • 2-Dimensional Ultrasound Imaging
    • 2D-US
    • Ultrasonography
    • Ultrasound
    • Ultrasound Test
    • Ultrasound, Medical
    • US

Recruiting Locations

University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764 35233
Contact:
Site Public Contact
205-934-0220
tmyrick@uab.edu

Anchorage Associates in Radiation Medicine
Anchorage 5879400, Alaska 5879092 98508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Breast Care and Surgery LLC
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Oncology and Hematology LLC
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Alaska Women's Cancer Care
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Katmai Oncology Group
Anchorage 5879400, Alaska 5879092 99508
Contact:
Site Public Contact
907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092 99508
Contact:
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907-212-6871
AKPAMC.OncologyResearchSupport@providence.org

Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752 85719
Contact:
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UACC-IIT@uacc.arizona.edu

University of Arizona Cancer Center-North Campus
Tucson 5318313, Arizona 5551752 85719
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UACC-IIT@uacc.arizona.edu

University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Contact:
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501-686-8274

Kaiser Permanente-Deer Valley Medical Center
Antioch 5324200, California 5332921 94531
Contact:
Site Public Contact
877-642-4691
Kpoct@kp.org

Tower Cancer Research Foundation
Beverly Hills 5328041, California 5332921 90211
Contact:
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towercancerresearch@toweroncology.com

Keck Medicine of USC Buena Park
Buena Park 5331575, California 5332921 90621
Contact:
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714-522-0908

Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank 5331835, California 5332921 91505
Contact:
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818-847-4793
Najee.Boucher@providence.org

City of Hope Comprehensive Cancer Center
Duarte 5344147, California 5332921 91010
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800-826-4673
becomingapatient@coh.org

Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
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877-642-4691

Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
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877-642-4691
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Fresno Cancer Center
Fresno 5350937, California 5332921 93720
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877-642-4691
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Kaiser Permanente-Fresno
Fresno 5350937, California 5332921 93720
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877-642-4691
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City of Hope Seacliff
Huntington Beach 5358705, California 5332921 92648
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626-256-4673

Keck Medicine of USC Huntington Beach
Huntington Beach 5358705, California 5332921 92648
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714-861-1000
karenn@pacshoresoncology.com

City of Hope at Irvine Lennar
Irvine 5359777, California 5332921 92618
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877-467-3411

Kaiser Permanente-Irvine
Irvine 5359777, California 5332921 92618
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800-398-3996
clinical.trials@kp.org

City of Hope Antelope Valley
Lancaster 5364940, California 5332921 93534
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800-826-4673
becomingapatient@coh.org

Keck Medicine of USC Koreatown
Los Angeles 5368361, California 5332921 90020
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213-388-0908

Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921 90027
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800-398-3996
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Los Angeles General Medical Center
Los Angeles 5368361, California 5332921 90033
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323-865-0451
uscnorrisinfo@med.usc.edu

USC / Norris Comprehensive Cancer Center
Los Angeles 5368361, California 5332921 90033
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323-865-0451

Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
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310-423-8965

UCLA / Jonsson Comprehensive Cancer Center
Los Angeles 5368361, California 5332921 90095
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888-798-0719

Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
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877-642-4691
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Providence Queen of The Valley
Napa 5376095, California 5332921 94558
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707-521-3830

USC Norris Oncology/Hematology-Newport Beach
Newport Beach 5376890, California 5332921 92663
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323-865-0451

Kaiser Permanente Oakland-Broadway
Oakland 5378538, California 5332921 94611
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877-642-4691
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Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
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877-642-4691
Kpoct@kp.org

Kaiser Permanente - Panorama City
Panorama City 5380932, California 5332921 91402
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800-398-3996
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Huntington Memorial Hospital
Pasadena 5381396, California 5332921 91105
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626-535-2420

Keck Medical Center of USC Pasadena
Pasadena 5381396, California 5332921 91105
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323-865-0451

Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova 5385941, California 5332921 95670
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877-642-4691
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Kaiser Permanente- Marshall Medical Offices
Redwood City 5386834, California 5332921 94063
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877-642-4691

Kaiser Permanente-Redwood City
Redwood City 5386834, California 5332921 94063
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877-642-4691
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Kaiser Permanente-Richmond
Richmond 5387428, California 5332921 94801
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877-642-4691
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Kaiser Permanente-Riverside
Riverside 5387877, California 5332921 92505
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800-398-3996
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Rohnert Park Cancer Center
Rohnert Park 5388564, California 5332921 94928
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
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877-642-4691
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The Permanente Medical Group-Roseville Radiation Oncology
Roseville 5388881, California 5332921 95678
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877-642-4691
Kpoct@kp.org

Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
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877-642-4691
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University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
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916-734-3089

Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
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877-642-4691
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South Sacramento Cancer Center
Sacramento 5389489, California 5332921 95823
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877-642-4691
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Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
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877-642-4691
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UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921 94158
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877-827-3222
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Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
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877-642-4691
Kpoct@kp.org

Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
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877-642-4691
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Kaiser San Rafael-Gallinas
San Rafael 5392567, California 5332921 94903
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877-642-4691
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Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
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877-642-4691
Kpoct@kp.org

Providence Medical Foundation - Santa Rosa
Santa Rosa 5393287, California 5332921 95403
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707-521-3830

Providence Santa Rosa Memorial Hospital
Santa Rosa 5393287, California 5332921 95405
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707-521-3830

City of Hope South Pasadena
South Pasadena 5397717, California 5332921 91030
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800-826-4673
becomingapatient@coh.org

Kaiser Permanente Cancer Treatment Center
South San Francisco 5397765, California 5332921 94080
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Stockton
Stockton 5399020, California 5332921 95210
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877-642-4691
Kpoct@kp.org

City of Hope South Bay
Torrance 5403022, California 5332921 90503
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877-467-3411

Torrance Memorial Physician Network - Cancer Care
Torrance 5403022, California 5332921 90505
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310-750-3300
courtney.steeneken@tmphysicians.com

City of Hope Upland
Upland 5404915, California 5332921 91786
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800-826-4673
becomingapatient@coh.org

Kaiser Permanente Medical Center-Vacaville
Vacaville 5405228, California 5332921 95688
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
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877-642-4691
Kpoct@kp.org

Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
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877-642-4691
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UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
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720-848-0650

UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
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719-365-2406

Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
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719-364-6700

UCHealth Highlands Ranch Hospital
Highlands Ranch 5425043, Colorado 5417618 80129
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720-848-0650

Danbury Hospital
Danbury 4832353, Connecticut 4831725 06810
Contact:
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203-739-8074

Smilow Cancer Hospital Care Center at Greenwich
Greenwich 4835395, Connecticut 4831725 06830
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Hartford Hospital
Hartford 4835797, Connecticut 4831725 06102
Contact:
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860-545-5363

The Hospital of Central Connecticut
New Britain 4839292, Connecticut 4831725 06050
Contact:
Site Public Contact
860-224-5660

Smilow Cancer Center/Yale-New Haven Hospital
New Haven 4839366, Connecticut 4831725 06510
Contact:
Site Public Contact
203-785-5702
canceranswers@yale.edu

Yale University
New Haven 4839366, Connecticut 4831725 06520
Contact:
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203-785-5702
canceranswers@yale.edu

Norwalk Hospital
Norwalk 4839822, Connecticut 4831725 06856
Contact:
Site Public Contact
203-852-2996
jennifer.long@norwalkhealth.org

Smilow Cancer Hospital Care Center - Waterford
Waterford 8480031, Connecticut 4831725 06385
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Site Public Contact
203-785-5702
canceranswers@yale.edu

Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224 19718
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Site Public Contact
302-623-4450
lbarone@christianacare.org

Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224 19801
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

George Washington University Medical Center
Washington D.C. 4140963, District of Columbia 4138106 20037
Contact:
Site Public Contact
202-741-2981

UM Sylvester Comprehensive Cancer Center at Aventura
Aventura 4146429, Florida 4155751 33180
Contact:
Site Public Contact
954-461-2180

Florida Cancer Specialists - Bradenton Cancer Center
Bradenton 4148708, Florida 4155751 34205
Contact:
Site Public Contact
239-274-9930
clinicaltrials@flcancer.com

UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables 4151871, Florida 4155751 33146
Contact:
Site Public Contact
305-243-2647

UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach 4153071, Florida 4155751 33442
Contact:
Site Public Contact
305-243-2647

UM Sylvester Comprehensive Cancer Center at Doral
Doral 4153471, Florida 4155751 33166
Contact:
Site Public Contact
kginnity@med.miami.edu

GenesisCare USA - FGO
Fort Myers 4155995, Florida 4155751 33905
Contact:
Site Public Contact
941-833-5700
Rudi.Ross@usa.genesiscare.com

Regional Cancer Center-Lee Memorial Health System
Fort Myers 4155995, Florida 4155751 33905
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

University of Florida Health Science Center - Gainesville
Gainesville 4156404, Florida 4155751 32610
Contact:
Site Public Contact
352-273-8010
cancer-center@ufl.edu

Jackson Memorial Hospital-Holtz Children's Hospital
Miami 4164138, Florida 4155751 33136
Contact:
Site Public Contact
305-243-3975

University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751 33136
Contact:
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305-243-2647

UM Sylvester Comprehensive Cancer Center at Kendall
Miami 4164138, Florida 4155751 33176
Contact:
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305-243-2647

Sarasota Memorial Hospital-Venice
N. Venice, Florida 4155751 34275
Contact:
Site Public Contact
941-261-9000

UM Sylvester Comprehensive Cancer Center at Plantation
Plantation 4168782, Florida 4155751 33324
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305-243-2647

Florida Cancer Specialists - Sarasota
Sarasota 4172131, Florida 4155751 34232
Contact:
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412-339-5294
Roster@nrgoncology.org

Intercoastal Medical Group - Cattleridge II
Sarasota 4172131, Florida 4155751 34232
Contact:
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941-200-1125

Florida Cancer Specialists - Sarasota Downtown
Sarasota 4172131, Florida 4155751 34236
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941-957-1000

First Physicians Group - Urology Robotic and Minimally Invasive Surgery
Sarasota 4172131, Florida 4155751 34239
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941-917-5400

First Physicians Group-Sarasota
Sarasota 4172131, Florida 4155751 34239
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941-917-8383

Sarasota Memorial Hospital
Sarasota 4172131, Florida 4155751 34239
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941-917-2225

Sarasota Memorial Health Care Center at University Parkway
Sarasota 4172131, Florida 4155751 34243
Contact:
Site Public Contact
941-917-6519

Florida Cancer Specialists - Venice Pinebrook
Venice 4176380, Florida 4155751 34275
Contact:
Site Public Contact
239-274-9930
ClinicalTrials@FLCancer.com

Florida Cancer Specialists - Venice Island
Venice 4176380, Florida 4155751 34285
Contact:
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412-339-5294
Roster@nrgoncology.org

Grady Health System
Atlanta 4180439, Georgia 4197000 30303
Contact:
Site Public Contact
404-778-1868

Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
888-946-7447

Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000 30322
Contact:
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404-778-1868

Emory Saint Joseph's Hospital
Atlanta 4180439, Georgia 4197000 30342
Contact:
Site Public Contact
404-851-7115

Northside Hospital
Atlanta 4180439, Georgia 4197000 30342
Contact:
Site Public Contact
404-303-3355
ClinicalTrials@northside.com

Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Contact:
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706-721-2388
ga_cares@augusta.edu

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah 4221552, Georgia 4197000 31405
Contact:
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912-819-5704
underberga@sjchs.org

Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797 96813
Contact:
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808-524-6115
i.webster@hawaiicancercare.com

Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-532-0315

Queen's Medical Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-545-8548

Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Contact:
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808-522-4333

University of Hawaii Cancer Center
Honolulu 5856195, Hawaii 5855797 96813
Contact:
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808-586-2979

Kuakini Medical Center
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-9816

Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-531-8521

The Cancer Center of Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-6881

Kaiser Permanente Moanalua Medical Center
Honolulu 5856195, Hawaii 5855797 96819
Contact:
Site Public Contact
808-432-5195
shelley.a.clark@kp.org

Kapiolani Medical Center for Women and Children
Honolulu 5856195, Hawaii 5855797 96826
Contact:
Site Public Contact
808-983-6090

Wilcox Memorial Hospital and Kauai Medical Clinic
Lihue 5850248, Hawaii 5855797 96766
Contact:
Site Public Contact
808-535-7960

Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
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808-539-2273
info@hawaiicancercare.com

Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-486-6000

Queen's Cancer Center - Pearlridge
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-487-7447

The Cancer Center of Hawaii-Pali Momi
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-678-9000

The Queen's Medical Center - West Oahu
‘Ewa Beach 5855051, Hawaii 5855797 96706
Contact:
Site Public Contact
rohta@queens.org

Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Contact:
Site Public Contact
208-381-2774
eslinget@slhs.org

Rush - Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

Advocate Outpatient Center - Aurora
Aurora 4883817, Illinois 4896861 60506
Contact:
Site Public Contact
ncorp@aah.org

Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847

Carle BroMenn Outpatient Center
Bloomington 4885164, Illinois 4896861 61704
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Northwestern University
Chicago 4887398, Illinois 4896861 60611
Contact:
Site Public Contact
312-695-1301
cancer@northwestern.edu

Rush University Medical Center
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-942-5498
clinical_trials@rush.edu

University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360

AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocate.com

Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Contact:
Site Public Contact
630-275-1270
Barbara.barhamand@advocatehealth.com

Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907

Elmhurst Memorial Hospital
Elmhurst 4891010, Illinois 4896861 60126
Contact:
Site Public Contact
630-758-5460
Jrohde@emhc.org

NorthShore University HealthSystem-Evanston Hospital
Evanston 4891382, Illinois 4896861 60201
Contact:
Site Public Contact
847-570-2109

Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

NorthShore University HealthSystem-Glenbrook Hospital
Glenview 4893886, Illinois 4896861 60026
Contact:
Site Public Contact
847-570-2109

Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995

NorthShore University HealthSystem-Highland Park Hospital
Highland Park 4895876, Illinois 4896861 60035
Contact:
Site Public Contact
847-570-2109

Northwestern Medicine Lake Forest Hospital
Lake Forest 4899012, Illinois 4896861 60045
Contact:
Site Public Contact
cancertrials@northwestern.edu

AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Contact:
Site Public Contact
630-929-6129
advocateresearch@advocatehealth.com

Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Edward Hospital/Cancer Center
Naperville 4903279, Illinois 4896861 60540
Contact:
Site Public Contact
630-646-6075

UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861 60451
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Carle BroMenn Medical Center
Normal 4903780, Illinois 4896861 61761
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Carle Cancer Institute Normal
Normal 4903780, Illinois 4896861 61761
Contact:
Site Public Contact
800-446-5532
Research@Carle.com

Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622

Oak Park Hospital
Oak Park 4904381, Illinois 4896861 60304
Contact:
Site Public Contact
312-563-3347
Dawn_Paulsen@rush.edu

University of Chicago Medicine-Orland Park
Orland Park 4904937, Illinois 4896861 60462
Contact:
Site Public Contact
773-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621

Edward Hospital/Cancer Center?Plainfield
Plainfield 4906125, Illinois 4896861 60585
Contact:
Site Public Contact
630-646-6075
Cancerresearch@edward.org

Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861 61801
Contact:
Site Public Contact
800-446-5532
Research@carle.com

Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Contact:
Site Public Contact
630-352-5360
Donald.Smith3@nm.org

Rush-Copley Healthcare Center
Yorkville 4917298, Illinois 4896861 60560
Contact:
Site Public Contact
630-978-6212
Cancer.Research@rushcopley.com

IU Health North Hospital
Carmel 4255466, Indiana 4921868 46032
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

UChicago Medicine Northwest Indiana
Crown Point 4919451, Indiana 4921868 46307
Contact:
Site Public Contact
855-702-8222
cancerclinicaltrials@bsd.uchicago.edu

Goshen Center for Cancer Care
Goshen 4920808, Indiana 4921868 46526
Contact:
Site Public Contact
574-364-2973
cccois@goshenhealth.com

Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis 4259418, Indiana 4921868 46202
Contact:
Site Public Contact
317-278-5632
iutrials@iu.edu

Ascension Saint Vincent Indianapolis Hospital
Indianapolis 4259418, Indiana 4921868 46260
Contact:
Site Public Contact
317-338-2194
research@stvincent.org

Heartland Oncology and Hematology LLP
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
712-322-4136

Methodist Jennie Edmundson Hospital
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
402-354-7939
kathryn.bartz@nmhs.org

Nebraska Cancer Specialists/Oncology Hematology West PC - MEJ
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
402-354-5892
Liza.brandes@nmhs.org

University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182 52242
Contact:
Site Public Contact
800-237-1225

University of Kansas Clinical Research Center
Fairway 4271358, Kansas 4273857 66205
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Hospital-Indian Creek Campus
Overland Park 4276873, Kansas 4273857 66211
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Baptist Health Corbin
Corbin 4288656, Kentucky 6254925 40701
Contact:
Site Public Contact
859-523-1934

Saint Elizabeth Healthcare Edgewood
Edgewood 4290873, Kentucky 6254925 41017
Contact:
Site Public Contact
859-301-4730
barbara.logan@stelizabeth.com

Baptist Health Lexington
Lexington 4297983, Kentucky 6254925 40503
Contact:
Site Public Contact
859-260-6425

Norton Hospital Pavilion and Medical Campus
Louisville 4299276, Kentucky 6254925 40202
Contact:
Site Public Contact
502-629-2500
cancerresearch@nortonhealthcare.org

Baptist Health Louisville
Louisville 4299276, Kentucky 6254925 40207
Contact:
Site Public Contact
502-897-8592
Cbcresearch@bhsi.com

Norton Suburban Hospital and Medical Campus
Louisville 4299276, Kentucky 6254925 40207
Contact:
Site Public Contact
502-629-3465

Baptist Health Paducah
Paducah 4048662, Kentucky 6254925 42003
Contact:
Site Public Contact
270-575-2928

West Jefferson Medical Center
Marrero 4332628, Louisiana 4331987 70072
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Louisiana State University Health Science Center
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

Willis-Knighton Medical and Cancer Center
Shreveport 4341513, Louisiana 4331987 71103
Contact:
Site Public Contact
504-210-3539
emede1@lsuhsc.edu

MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Contact:
Site Public Contact
207-396-8670
clinicalresearch@mainehealth.org

Walter Reed National Military Medical Center
Bethesda 4348599, Maryland 4361885 20889-5600
Contact:
Site Public Contact
301-319-2100

Christiana Care - Union Hospital
Elkton 4354234, Maryland 4361885 21921
Contact:
Site Public Contact
410-443-1360
frank.crum@christianacare.org

Baystate Medical Center
Springfield 4951788, Massachusetts 6254926 01199
Contact:
Site Public Contact
413-794-3565
tamara.wrenn@baystatehealth.org

Corewell Health Dearborn Hospital
Dearborn 4990510, Michigan 5001836 48124
Contact:
Site Public Contact
248-551-7695

Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836 48201
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836 48334
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health Farmington Hills Hospital
Farmington Hills 4992523, Michigan 5001836 48336
Contact:
Site Public Contact
248-551-7695

McLaren Cancer Institute-Flint
Flint 4992982, Michigan 5001836 48532
Contact:
Site Public Contact
313-576-9790
ctoadmin@karmanos.org

Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Ascension Borgess Hospital
Kalamazoo 4997787, Michigan 5001836 49048
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836 49444
Contact:
Site Public Contact
616-391-1230
crcwm-regulatory@crcwm.org

Oakland Colon Rectal Associates
Royal Oak 5007804, Michigan 5001836 48067
Contact:
Site Public Contact
248-551-7695

Cancer Care Associates PC
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Comprehensive Medical Center PLLC
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Hematology Oncology Consultants PC-Royal Oak
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Oakland Medical Group
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695

Premier Hematology Oncology Care
Sterling Heights 5011148, Michigan 5001836 48312
Contact:
Site Public Contact
248-551-7695

Michigan Institute of Urology-Town Center
Troy 5012639, Michigan 5001836 48084
Contact:
Site Public Contact
248-551-7695

Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695

Hematology Oncology Consultants PC-Troy
Troy 5012639, Michigan 5001836 48098
Contact:
Site Public Contact
248-551-7695

Minnesota Oncology - Burnsville
Burnsville 5019767, Minnesota 5037779 55337
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Cambridge Medical Center
Cambridge 5020068, Minnesota 5037779 55008
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779 55369
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779 55109
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Health Partners Inc
Minneapolis 5037649, Minnesota 5037779 55454
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

University of Minnesota/Masonic Cancer Center
Minneapolis 5037649, Minnesota 5037779 55455
Contact:
Site Public Contact
612-624-2620

Monticello Cancer Center
Monticello 5038045, Minnesota 5037779 55362
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

New Ulm Medical Center
New Ulm 5039173, Minnesota 5037779 56073
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Northland Medical Center
Princeton 5042360, Minnesota 5037779 55371
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779 55422
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015

Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

United Hospital
Saint Paul 5045360, Minnesota 5037779 55102
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779 55379
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Lakeview Hospital
Stillwater 5048814, Minnesota 5037779 55082
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779 55387
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779 56201
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Minnesota Oncology Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779 55125
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Fairview Lakes Medical Center
Wyoming 5053526, Minnesota 5037779 55092
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City 4400860, Missouri 4398678 64116
Contact:
Site Public Contact
913-588-3671
KUCC_Navigation@kumc.edu

Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520

CoxHealth South Hospital
Springfield 4409896, Missouri 4398678 65807
Contact:
Site Public Contact
417-269-4520

Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
Contact:
Site Public Contact
800-600-3606
info@siteman.wustl.edu

Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569

Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Contact:
Site Public Contact
800-996-2663
research@billingsclinic.org

Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Contact:
Site Public Contact
406-969-6060
mccinfo@mtcancer.org

Saint Patrick Hospital - Community Hospital
Missoula 5666639, Montana 5667009 59802
Contact:
Site Public Contact
406-327-3118
amy.hanneman@providence.org

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-334-4773

Nebraska Methodist Hospital
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-354-5144

Oncology Associates PC
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-354-5860
info@oa-oc.com

Nebraska Medicine-Village Pointe
Omaha 5074472, Nebraska 5073708 68118
Contact:
Site Public Contact
402-559-5600

University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Contact:
Site Public Contact
402-559-6941
unmcrsa@unmc.edu

Women's Cancer Center of Nevada
Las Vegas 5506956, Nevada 5509151 89106
Contact:
Site Public Contact
702-851-4672

Memorial Sloan Kettering Basking Ridge
Basking Ridge 5095409, New Jersey 5101760 07920
Contact:
Site Public Contact
212-639-7592

Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760 08103
Contact:
Site Public Contact
856-325-6757

Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760 07302
Contact:
Site Public Contact
412-339-5294
Roster@nrgoncology.org

Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Contact:
Site Public Contact
973-322-2934
joanne.loeb@rwjbh.org

Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
Contact:
Site Public Contact
212-639-7592

Memorial Sloan Kettering Bergen
Montvale 5101361, New Jersey 5101760 07645
Contact:
Site Public Contact
212-639-7592

Morristown Medical Center
Morristown 5101427, New Jersey 5101760 07960
Contact:
Site Public Contact
973-971-5900

Virtua Memorial
Mount Holly 4503134, New Jersey 5101760 08060
Contact:
Site Public Contact
609-914-6762

Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356

Rutgers New Jersey Medical School
Newark 5101798, New Jersey 5101760 07101
Contact:
Site Public Contact
732-235-7356

Capital Health Medical Center-Hopewell
Pennington 5102535, New Jersey 5101760 08534
Contact:
Site Public Contact
609-394-4130
clinicaltrials@capitalhealth.org

Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Contact:
Site Public Contact
908-685-2481
Siby.Varughese@rwjbh.org

Overlook Hospital
Summit 5105127, New Jersey 5101760 07902
Contact:
Site Public Contact
908-522-2043

Virtua Voorhees
Voorhees Township 5105860, New Jersey 5101760 08043
Contact:
Site Public Contact
856-247-7395
nctn@pennmedicine.upenn.edu

University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Contact:
Site Public Contact
505-925-0348
HSC-ClinicalTrialInfo@salud.unm.edu

Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Contact:
Site Public Contact
505-559-6113
WBurman@phs.org

Women's Cancer Care Associates LLC
Albany 5106834, New York 5128638 12208
Contact:
Site Public Contact
518-458-1390
jbarlin@womenscancercareassociates.com

Northwell Health Imbert Cancer Center
Bay Shore 5108169, New York 5128638 11706
Contact:
Site Public Contact
516-734-8896

South Shore University Hospital
Bay Shore 5108169, New York 5128638 11706
Contact:
Site Public Contact
516-734-8896

Island Gynecologic Oncology
Brightwaters 5110168, New York 5128638 11718
Contact:
Site Public Contact
516-734-8896

Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
Contact:
Site Public Contact
212-639-7592

Northwell Health Physician Partners at Flushing
Flushing 5117472, New York 5128638 11354
Contact:
Site Public Contact
718-559-3600
nhppflushing@northwell.edu

Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592

Huntington Hospital
Huntington 5121636, New York 5128638 11743
Contact:
Site Public Contact
516-734-8896

Northwell Health/Center for Advanced Medicine
Lake Success 5123853, New York 5128638 11042
Contact:
Site Public Contact
516-734-8896

North Shore University Hospital
Manhasset 5125766, New York 5128638 11030
Contact:
Site Public Contact
516-734-8896

NYU Langone Hospital - Long Island
Mineola 5127134, New York 5128638 11501
Contact:
Site Public Contact
212-263-4432
cancertrials@nyulangone.org

Northern Westchester Hospital
Mount Kisco 5127744, New York 5128638 10549
Contact:
Site Public Contact
914-666-1366
AMellor@northwell.edu

Long Island Jewish Medical Center
New Hyde Park 5128514, New York 5128638 11040
Contact:
Site Public Contact
516-734-8896

Northwell Health Physician Partners
New Hyde Park 5128514, New York 5128638 11042
Contact:
Site Public Contact
516-734-8896

Mount Sinai Chelsea
New York 5128581, New York 5128638 10011
Contact:
Site Public Contact
212-824-7309
CCTO@mssm.edu

Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York 5128581, New York 5128638 10016
Contact:
Site Public Contact
CancerTrials@nyulangone.org

Mount Sinai West
New York 5128581, New York 5128638 10019
Contact:
Site Public Contact
212-824-7309
CCTO@mssm.edu

Mount Sinai Hospital
New York 5128581, New York 5128638 10029
Contact:
Site Public Contact
212-824-7309
CCTO@mssm.edu

Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592

NYP/Weill Cornell Medical Center
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-746-1848

Lenox Hill Hospital
New York 5128581, New York 5128638 10075
Contact:
Site Public Contact
516-734-8896

Vassar Brothers Medical Center
Poughkeepsie 5132143, New York 5128638 12601
Contact:
Site Public Contact
845-483-6483

Northwell Physician Partners at Rego Park
Rego Park 5133640, New York 5128638 11374
Contact:
Site Public Contact
516-734-8896

Queens Cancer Center
Rego Park 5133640, New York 5128638 11374
Contact:
Site Public Contact
718-312-3446

Highland Hospital
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113

University of Rochester
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830

Phelps Memorial Hospital Center
Sleepy Hollow 5138371, New York 5128638 10591
Contact:
Site Public Contact
914-366-1600

Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215

State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476

Memorial Sloan Kettering Nassau
Uniondale 5141927, New York 5128638 11553
Contact:
Site Public Contact
212-639-7592

Duke Cancer Center Cary
Cary 4459467, North Carolina 4482348 27518
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Contact:
Site Public Contact
877-668-0683
cancerclinicaltrials@med.unc.edu

Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853

Duke Women's Cancer Care Raleigh
Raleigh 4487042, North Carolina 4482348 27607
Contact:
Site Public Contact
919-785-4878

Duke Cancer Center Raleigh
Raleigh 4487042, North Carolina 4482348 27609
Contact:
Site Public Contact
NCTNStudyTeam@dm.duke.edu

Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348 27157
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336-713-6771

Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
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866-223-8100
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OhioHealth O'Bleness Hospital
Athens 4505542, Ohio 5165418 45701
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614-788-3860
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Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Contact:
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937-528-2900
clinical.trials@daytonncorp.org

University of Cincinnati Cancer Center-UC Medical Center
Cincinnati 4508722, Ohio 5165418 45219
Contact:
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513-584-7698
cancer@uchealth.com

Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
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720-874-1881
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Bethesda North Hospital
Cincinnati 4508722, Ohio 5165418 45242
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720-874-1881
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TriHealth Cancer Institute-Westside
Cincinnati 4508722, Ohio 5165418 45247
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720-874-1881
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TriHealth Cancer Institute-Anderson
Cincinnati 4508722, Ohio 5165418 45255
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720-874-1881
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MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418 44109
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216-778-7559
ababal@metrohealth.org

Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland 5150529, Ohio 5165418 44111
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866-223-8100
TaussigResearch@ccf.org

Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418 44195
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866-223-8100
TaussigResearch@ccf.org

Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
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800-293-5066
Jamesline@osumc.edu

Columbus Oncology and Hematology Associates Inc
Columbus 4509177, Ohio 5165418 43214
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Contact:
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937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Contact:
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937-528-2900
clinical.trials@daytonncorp.org

Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
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614-788-3860
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Grady Memorial Hospital
Delaware 5151891, Ohio 5165418 43015
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Columbus Oncology and Hematology Associates
Dublin 5152333, Ohio 5165418 43016
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614-788-3860
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Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Contact:
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937-528-2900
clinical.trials@daytonncorp.org

Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
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937-569-7515

OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
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614-788-3860
Jennifer.Sexton@ohiohealth.com

OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
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614-788-3860
Jennifer.Sexton@ohiohealth.com

Hillcrest Hospital Cancer Center
Mayfield Heights 5162188, Ohio 5165418 44124
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866-223-8100
TaussigResearch@ccf.org

OhioHealth Pickerington Methodist Hospital
Pickerington 4521209, Ohio 5165418 43147
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614-788-3860
Jennifer.Sexton@ohiohealth.com

ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
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419-824-1842
PCIOncResearch@promedica.org

ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418 43606
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419-824-1842
PCIOncResearch@promedica.org

Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
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937-528-2900
clinical.trials@daytonncorp.org

University of Cincinnati Cancer Center-West Chester
West Chester 4520522, Ohio 5165418 45069
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513-584-7698
cancer@uchealth.com

OhioHealth Westerville Medical Campus/Westerville Cancer Center
Westerville 5176472, Ohio 5165418 43082
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610-788-3860
Jennifer.Sexton@ohiohealth.com

University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Contact:
Site Public Contact
405-271-8777
ou-clinical-trials@ouhsc.edu

Mercy Hospital Oklahoma City
Oklahoma City 4544349, Oklahoma 4544379 73120
Contact:
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405-752-3402

Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
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541-706-2909
nosall@stcharleshealthcare.org

Clackamas Radiation Oncology Center
Clackamas 5719308, Oregon 5744337 97015
Contact:
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503-215-2614
CanRsrchStudies@providence.org

Bay Area Hospital
Coos Bay 5720495, Oregon 5744337 97420
Contact:
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541-269-8392
cherie.cox@bayareahospital.org

Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Contact:
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503-215-2614
CanRsrchStudies@providence.org

Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Contact:
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503-215-2614
CanRsrchStudies@providence.org

Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Contact:
Site Public Contact
800-220-4937
cancer@lhs.org

Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Contact:
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503-215-2614
CanRsrchStudies@providence.org

Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Contact:
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503-215-2614
CanRsrchStudies@providence.org

Oregon Health and Science University
Portland 5746545, Oregon 5744337 97239
Contact:
Site Public Contact
503-494-1080
trials@ohsu.edu

Saint Charles Health System-Redmond
Redmond 5747882, Oregon 5744337 97756
Contact:
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541-706-2909

Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Contact:
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503-413-1742

Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Contact:
Site Public Contact
302-623-4450
lbarone@christianacare.org

Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Contact:
Site Public Contact
717-531-3779
CTO@hmc.psu.edu

Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Contact:
Site Public Contact
412-359-3043
ddefazio@wpahs.org

Lancaster General Ann B Barshinger Cancer Institute
Lancaster 5197079, Pennsylvania 6254927 17601
Contact:
Site Public Contact
717-544-0511
nctn@pennmedicine.upenn.edu

Lancaster General Hospital
Lancaster 5197079, Pennsylvania 6254927 17602
Contact:
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717-544-5511
nctn@pennmedicine.upenn.edu

Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
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412-858-7746

Allegheny Valley Hospital
Natrona Heights 5202903, Pennsylvania 6254927 15065
Contact:
Site Public Contact
Dawnmarie.DeFazio@ahn.org

University of Pennsylvania/Abramson Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19104
Contact:
Site Public Contact
855-216-0098
PennCancerTrials@careboxhealth.com

Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19111
Contact:
Site Public Contact
215-728-4790

Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000

UPMC-Magee Womens Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15213
Contact:
Site Public Contact
412-647-2811

West Penn Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15224
Contact:
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412-578-5000

University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073

Chester County Hospital
West Chester 4562144, Pennsylvania 6254927 19380
Contact:
Site Public Contact
610-431-5044
carolann.hoppes@pennmedicine.upenn.edu

Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
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Dawnmarie.DeFazio@ahn.org

Women and Infants Hospital
Providence 5224151, Rhode Island 5224323 02905
Contact:
Site Public Contact
401-274-1122

Saint Joseph's/Candler - Bluffton Campus
Bluffton 4571722, South Carolina 4597040 29910
Contact:
Site Public Contact
912-819-5704
underberga@sjchs.org

Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Contact:
Site Public Contact
843-792-9321
hcc-clinical-trials@musc.edu

Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040 29341
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Prisma Health Cancer Institute - Faris
Greenville 4580543, South Carolina 4597040 29605
Contact:
Site Public Contact
864-241-6251

Prisma Health Greenville Memorial Hospital
Greenville 4580543, South Carolina 4597040 29605
Contact:
Site Public Contact
864-241-6251

Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Prisma Health Cancer Institute - Seneca
Seneca 4595346, South Carolina 4597040 29672
Contact:
Site Public Contact
864-241-6251

Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040 29379
Contact:
Site Public Contact
864-560-6104
kmertz-rivera@gibbscc.org

Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Contact:
Site Public Contact
605-312-3320
OncologyClinicTrialsSF@sanfordhealth.org

Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Contact:
Site Public Contact
605-312-3320
OncologyClinicalTrialsSF@SanfordHealth.org

Vanderbilt-Ingram Cancer Center at Franklin
Franklin 4623560, Tennessee 4662168 37067
Contact:
Site Public Contact
800-811-8480

Vanderbilt-Ingram Cancer Center Cool Springs
Franklin 4623560, Tennessee 4662168 37067
Contact:
Site Public Contact
800-811-8480

Vanderbilt Breast Center at One Hundred Oaks
Nashville 4644585, Tennessee 4662168 37204
Contact:
Site Public Contact
800-811-8480

Vanderbilt University/Ingram Cancer Center
Nashville 4644585, Tennessee 4662168 37232
Contact:
Site Public Contact
800-811-8480

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-798-1354
burton@bcm.edu

Ben Taub General Hospital
Houston 4699066, Texas 4736286 77030
Contact:
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713-873-2000

Memorial Hermann Texas Medical Center
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-792-3245

University of Utah Sugarhouse Health Center
Salt Lake City 5780993, Utah 5549030 84106
Contact:
Site Public Contact
888-424-2100
cancerinfo@hci.utah.edu

Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
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888-424-2100
cancerinfo@hci.utah.edu

University of Virginia Cancer Center
Charlottesville 4752031, Virginia 6254928 22908
Contact:
Site Public Contact
434-243-6303
uvacancertrials@hscmail.mcc.virginia.edu

Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Inova Fair Oaks Hospital
Fairfax 4758023, Virginia 6254928 22033
Contact:
Site Public Contact
703-720-5210
Stephanie.VanBebber@inova.org

Inova Fairfax Hospital
Falls Church 4758390, Virginia 6254928 22042
Contact:
Site Public Contact
703-208-6650
Stephanie.VanBebber@inova.org

Henrico Doctor's Hospital
Richmond 4781708, Virginia 6254928 23229
Contact:
Site Public Contact
804-289-4902
chbgynonc@gmail.com

VCU Massey Cancer Center at Stony Point
Richmond 4781708, Virginia 6254928 23235
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Site Public Contact
ctoclinops@vcu.edu

Virginia Commonwealth University/Massey Cancer Center
Richmond 4781708, Virginia 6254928 23298
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Site Public Contact
CTOclinops@vcu.edu

Carilion Roanoke Memorial Hospital
Roanoke 4782167, Virginia 6254928 24033
Contact:
Site Public Contact
540-985-8510

Providence Regional Cancer System-Aberdeen
Aberdeen 5785243, Washington 5815135 98520
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

PeaceHealth Saint Joseph Medical Center
Bellingham 5786899, Washington 5815135 98225
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360-788-8223

Providence Regional Cancer System-Centralia
Centralia 5789683, Washington 5815135 98531
Contact:
Site Public Contact
360-412-8958
deidre.dillon@providence.org

Swedish Cancer Institute-Edmonds
Edmonds 5793427, Washington 5815135 98026
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Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Providence Regional Cancer Partnership
Everett 5793933, Washington 5815135 98201
Contact:
Site Public Contact
425-261-3529
marilyn.birchman@providence.org

Swedish Cancer Institute-Issaquah
Issaquah 5798487, Washington 5815135 98029
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Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Kadlec Clinic Hematology and Oncology
Kennewick 5799610, Washington 5815135 99336
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Site Public Contact
509-783-4637
research@kadlecmed.org

Providence Regional Cancer System-Lacey
Lacey 5800112, Washington 5815135 98503
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360-412-8958
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PeaceHealth Saint John Medical Center
Longview 5801617, Washington 5815135 98632
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360-514-2016
kmakin-bond@peacehealth.org

Skagit Regional Health Cancer Care Center
Mount Vernon 5804127, Washington 5815135 98274
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360-814-2182
rcccclinicalresearch@skagitvalleyhospital.org

Swedish Medical Center-Ballard Campus
Seattle 5809844, Washington 5815135 98107
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Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Fred Hutchinson Cancer Center
Seattle 5809844, Washington 5815135 98109
Contact:
Site Public Contact
800-804-8824

Swedish Medical Center-Cherry Hill
Seattle 5809844, Washington 5815135 98122-5711
Contact:
Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135 98122
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Site Public Contact
206-215-3086
PCRC-NCORP@Swedish.org

University of Washington Medical Center - Northwest
Seattle 5809844, Washington 5815135 98133
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Site Public Contact
800-804-8824

University of Washington Medical Center - Montlake
Seattle 5809844, Washington 5815135 98195
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800-804-8824

PeaceHealth United General Medical Center
Sedro-Woolley 5809902, Washington 5815135 98284
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Site Public Contact
360-788-8223
rcrompton@peacehealth.org

Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Contact:
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503-413-2150

Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Contact:
Site Public Contact
509-897-5993
Cheryl.Dodd@providence.org

United Hospital Center
Bridgeport 4800081, West Virginia 4826850 26330
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850 25304
Contact:
Site Public Contact
304-388-9944

WVUH-Berkely Medical Center
Martinsburg 4813878, West Virginia 4826850 25401
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Camden Clark Medical Center
Parkersburg 4817641, West Virginia 4826850 26101
Contact:
Site Public Contact
304-293-7374
cancertrialsinfo@hsc.wvu.edu

Princeton Community Hospital
Princeton 4819079, West Virginia 4826850 24740
Contact:
Site Public Contact
304-487-7515

Wheeling Hospital/Schiffler Cancer Center
Wheeling 5280854, West Virginia 4826850 26003
Contact:
Site Public Contact
304-243-6442

Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Saint Luke's South Shore
Cudahy 5249871, Wisconsin 5279468 53110
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Contact:
Site Public Contact
920-433-8889
WI_research_admin@hshs.org

Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Contact:
Site Public Contact
800-622-8922
clinicaltrials@cancer.wisc.edu

Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Contact:
Site Public Contact
800-782-8581
oncology.clinical.trials@marshfieldresearch.org

Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666

Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468 54017
Contact:
Site Public Contact
952-993-1517
mmcorc@healthpartners.com

Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
Contact:
Site Public Contact
414-302-2304
ncorp@aurora.org

More Details

NCT ID
NCT04251052
Status
Recruiting
Sponsor
NRG Oncology

Detailed Description

PRIMARY OBJECTIVE: I. To compare the non-inferiority of bilateral salpingectomy (BLS) with delayed oophorectomy to bilateral salpingo-oophorectomy (BSO) to reduce the risk of ovarian cancer among individuals with deleterious BRCA1 germline mutations. SECONDARY OBJECTIVES: I. To prospectively assess estrogen deprivation symptoms in pre-menopausal BLS patients as measured by the Functional Assessment of Cancer Therapy - Endocrine Symptom (FACT-ES) subscale compared to pre-menopausal patients in the BSO arm. II. To determine if health-related quality of life (QOL) (FACT) is negatively impacted by menopausal symptoms (menopausal symptom checklist-Menopausal Symptom Checklist [MSCL]) and sexual dysfunction (Female Sexual Function Index [FSFI]) in pre-menopausal patients who have undergone BLS, in comparison to normative data (MSCL/FACT-ES) and data from pre-menopausal BSO patients. III. To determine if health-related QOL (FACT) is negatively impacted by cancer distress (Impact of Event Scale [IES]) in individuals who have undergone BLS, in comparison to BSO patients. IV. To assess medical decision making, as measured by the Shared Decision Making Questionnaire (SDM-Q-9) and Decision Regret Scale (DRS), and determine factors associated with the risk of reducing surgical treatment choice. V. To assess adverse events, graded using Common Terminology Criteria for Adverse Events (CTCAE) version (v)5.0. EXPLORATORY OBJECTIVES: I. Sexual dysfunction, as measured by selected Patient-Reported Outcomes Measurement Information System (PROMIS) screener and external sexual function items (pre-menopausal patients). II. To estimate the cost-effectiveness of BLS compared to BSO for ovarian cancer risk reduction. III. To assess medical decision making, as measured by the Risk-Reducing Medical Decision Making (RR-MDM) survey, a targeted set of questions on risk reducing surgical treatment choice. TRANSLATIONAL RESEARCH OBJECTIVE: I. To bank tissue and blood biospecimens for future research. OUTLINE: Patients choose between 1 of 2 groups. GROUP I: Patients undergo bilateral salpingectomy. Patients may then undergo oophorectomy after initial surgery. GROUP II: Patients undergo bilateral salpingo-oophorectomy. Patients in both groups also undergo a pelvic or transvaginal ultrasound during screening and blood sample collection throughout the trial. After completion of study, patients are followed up at 10-60 days, 6, 12, and 24 months, and then annually for up to 20 years.

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.