T-DM1 and Tucatinib Compared with T-DM1 Alone in Preventing Relapses in People with High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
Purpose
This phase III trial studies how well trastuzumab emtansine (T-DM1) and tucatinib work in preventing breast cancer from coming back (relapsing) in patients with high risk, HER2 positive breast cancer. T-DM1 is a monoclonal antibody, called trastuzumab, linked to a chemotherapy drug, called DM1. Trastuzumab is a form of targeted therapy because it attaches to specific molecules (receptors) on the surface of cancer cells, known as HER2 receptors, and delivers DM1 to kill them. Tucatinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Giving T-DM1 and tucatinib may work better in preventing breast cancer from relapsing in patients with HER2 positive breast cancer compared to T-DM1 alone.
Conditions
- Anatomic Stage IA Breast Cancer AJCC V8
- Anatomic Stage II Breast Cancer AJCC V8
- Anatomic Stage IIA Breast Cancer AJCC V8
- Anatomic Stage IIB Breast Cancer AJCC V8
- Anatomic Stage III Breast Cancer AJCC V8
- Anatomic Stage IIIA Breast Cancer AJCC V8
- Anatomic Stage IIIB Breast Cancer AJCC V8
- Anatomic Stage IIIC Breast Cancer AJCC V8
- HER2 Positive Breast Carcinoma
- Invasive Breast Carcinoma
- Multifocal Breast Carcinoma
- Prognostic Stage I Breast Cancer AJCC V8
- Prognostic Stage IA Breast Cancer AJCC V8
- Prognostic Stage IB Breast Cancer AJCC V8
- Prognostic Stage II Breast Cancer AJCC V8
- Prognostic Stage IIA Breast Cancer AJCC V8
- Prognostic Stage IIB Breast Cancer AJCC V8
- Prognostic Stage III Breast Cancer AJCC V8
- Prognostic Stage IIIA Breast Cancer AJCC V8
- Prognostic Stage IIIB Breast Cancer AJCC V8
- Prognostic Stage IIIC Breast Cancer AJCC V8
- Synchronous Bilateral Breast Carcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- HER2-positive status will be based on pretreatment biopsy material and defined as an immunohistochemistry (IHC) score of 3+ and/or positive by in situ hybridization (ISH) according to current American Society of Clinical Oncology (ASCO) College of American Pathologists (CAP) guidelines. Central testing is not required * Known hormone receptor (HR) status as defined by ASCO/CAP guidelines (based on pretreatment biopsy material). Hormone receptor positive status can be determined by either known positive estrogen receptor (ER) or known positive progesterone receptor (PR) status; hormone receptor negative status must be determined by both known negative ER and known negative PR - Patients with clinical stage T1-4, N0-3 disease at presentation and residual invasive disease postoperatively as defined above are eligible. (Note: Patients with T1a/bN0 tumors are not eligible at initial breast cancer diagnosis are not eligible) - Patients with residual HR-negative, HER2 positive (+) disease in the breast and/or lymph nodes per the surgical pathology report are eligible; however, patients with HR+ HER2+ cancers must have node-positive residual disease per the surgical pathology report in order to qualify for the study. The presence of residual invasive disease in the breast is not mandatory for these patients - Patients with weakly ER-positive (1-10%) breast cancer (based on the pretreatment core biopsy) are eligible even if they have node-negative disease per the surgical pathology report - The residual disease tissue (breast and/or lymph nodes) is not required to be HER2-positive, as eligibility for NCI-2020-03770 (A011801) is based on a positive HER2 status at the time of the initial breast cancer diagnosis * Note: The presence of micrometastases in lymph nodes after preoperative therapy counts as residual disease, whereas the presence of isolated tumor cells does not - Patients with synchronous bilateral invasive disease are eligible provided both lesions were confirmed to be HER2-positive, and at least one of the lesions meets the criteria outlined above. Multifocal disease is allowed, as long as the largest biopsied breast tumor was HER2-positive - Patients must have received neoadjuvant chemotherapy with one of the following regimens: docetaxel/trastuzumab/pertuzumab (THP), paclitaxel/methotrexate/cisplatin (TMP), doxorubicin/cyclophosphamide/paclitaxel/trastuzumab/pertuzumab (AC-TH(P)); docetaxel/carboplatin/trastuzumab/pertuzumab (TCH(P)); fluorouracil/doxorubicin/cyclophosphamide-docetaxel/trastuzumab/pertuzumab (FAC-TH(P)), or fluorouracil/epirubicin/cyclophosphamide-docetaxel/trastuzumab/pertuzumab (FEC-TH(P)). Note: apart from TCHP, where T is docetaxel, treatment with docetaxel or paclitaxel is acceptable - Prior receipt of T-DM1 in the neoadjuvant setting is not allowed. - Prior treatment must have consisted of >= 6 cycles of chemotherapy and HER2-directed therapy, with a total duration of >= 12 weeks, including at least 9 weeks of preoperative taxane and trastuzumab with or without pertuzumab (or Food and Drug Administration [FDA]-approved biosimilars). Patients who have received at least 9 weeks of preoperative taxane, pertuzumab and margetuximab are also eligible if they received >= 6 cycles of systemic therapy prior to enrollment. Note: Patients who complete at least nine of a planned twelve doses of weekly paclitaxel, or three of a planned four doses of docetaxel, but discontinue prematurely due to toxicity are eligible. Patients receiving dose-dense chemotherapy regimens are also eligible. Prior use of nab-paclitaxel (Abraxane) instead of paclitaxel or docetaxel is permitted. Prior use of subcutaneous trastuzumab (Hylecta) and subcutaneous trastuzumab and pertuzumab (Phesgo) is also allowed. - Patients who received neoadjuvant systemic therapy which included experimental HER2-targeted therapy/therapies are potentially eligible, as long as the investigational agent was not a HER2-targeted antibody-drug conjugate (e.g. T-DM1, DS-8201a [trastuzumab deruxtecan]) or a HER2 targeted tyrosine kinase inhibitor (TKI) (e.g. tucatinib, lapatinib, neratinib). - Patients may have received =< 1 cycles of T-DM1 in the adjuvant setting. Note: These patients will be randomized to receive a further 14 cycles of T-DM1 and tucatinib/placebo as tolerated. The most recent cycle of T-DM1 should have been administered =< 5 weeks prior to registration * Note: Both of the following two criteria need to be met for the patient to be eligible for this study - An interval of no more than 12 weeks between the completion date of the last definitive treatment (e.g. postoperative chemotherapy or radiation, or if neither given, breast surgical date) and the date of registration. Concurrent radiation therapy is permitted while receiving study treatment - Patients must be registered on study within =< 180 days of the date of the most recent definitive breast cancer surgery (not including reconstructive surgery) - All systemic chemotherapy should have been completed preoperatively unless participating in EA1181 (CompassHER2 pathologic complete response [pCR]) or the BIG DECRESCENDO Trial (which is very similar to CompassHER2 pCR in terms of study design, drugs, and eligibility). However, patients who received 4 cycles of neoadjuvant THP off study can receive a further 2-4 cycles of chemotherapy postoperatively to meet eligibility for A011801. Patients who participated in EA1181 or MA41 and proceeded to surgery immediately after the de-escalated trial regimen must receive postoperative chemotherapy to complete a total of >= 6 cycles of systemic treatment prior to enrollment on A011801, as outlined above (e.g. 4 cycles pre-operatively, and 2 cycles post-operatively). The postoperative chemotherapy regimen prescribed is at the discretion of the treating oncologist (i.e. 2-4 cycles AC or THP, other). Continuation of trastuzumab + pertuzumab (HP) pre- or post-operatively as maintenance therapy (while awaiting a surgical date or an official pathology report) is allowed for all study participants - Toxicities related to prior systemic treatment should have resolved or be at baseline, apart from alopecia and peripheral neuropathy =< grade 1 - Adequate excision: surgical removal of all clinically evident disease in the breast and lymph nodes as follows: - Breast surgery: total mastectomy with no gross residual disease at the margin of resection, or breast-conserving surgery with histologically negative margins of excision - For patients who undergo breast-conserving surgery, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. Patients with margins positive for classic lobular carcinoma in situ (LCIS) are eligible without additional resection - Lymph node surgery ** The axilla needs to be evaluated with either sentinel node biopsy or axillary lymph node dissection. If patients have a sentinel lymph node biopsy and sentinel nodes are negative, no further axillary treatment is necessary. If patients have isolated tumor cells (ITCs) in the setting of residual breast disease, at least one of the following is required: axillary lymph node dissection (ALND) or planned nodal irradiation. If patients have micro- or macro-metastatic nodal disease, ALND and planned nodal irradiation are required. Of note, co-enrollment on Alliance A011202 is not allowed - Eastern Cooperative Oncology Group (ECOG) performance status 0-1 - Absolute neutrophil count (ANC) >= 1,000/mm^3 - Hemoglobin >= 8 g/dL (Note: packed red blood cells [PRBC] transfusion is not permitted to achieve eligibility) - Platelet count >= 100,000/mm^3 - Creatinine =< 1.5 x upper limit of normal (ULN) - Total bilirubin =< 1.0 x upper limit of normal (ULN) or direct bilirubin within the institutional normal range for patients with Gilbert's syndrome - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 2.5 x upper limit of normal (ULN) - Screening left ventricular ejection fraction (LVEF) >= 50% on echocardiogram (ECHO) or multiple-gated acquisition (MUGA) after receiving neoadjuvant chemotherapy and no decrease in LVEF by more than 15% absolute percentage points from the pre-chemotherapy LVEF. Or, if pre-chemotherapy LVEF was not assessed, the screening LVEF must be >= 55% after completion of neoadjuvant chemotherapy. Note: LVEF assessment may be repeated once up to 3 weeks following the initial screening assessment to assess eligibility
Exclusion Criteria
- No adjuvant treatment with any anti-cancer investigational drug within 28 days prior to registration - Not pregnant and not nursing, because this study involves an agent that has known genotoxic, mutagenic and teratogenic effects. Therefore, for women of childbearing potential only, a negative serum pregnancy test done =< 7 days prior to registration is required - Patients with known active and/or untreated hepatitis B or hepatitis C or chronic liver disease are ineligible. Patients with a diagnosis of hepatitis B or C that has been treated and cleared and normal liver function are eligible to participate in the study if the other eligibility parameters are met - Stage IV (metastatic) breast cancer - History of any prior (ipsi- or contralateral) invasive breast cancer within 3 years of registration - Patients with ER+ HER2+ residual invasive disease that is lymph node-negative per the surgical pathology report - Evidence of recurrent disease following preoperative therapy and surgery - Patients for whom radiotherapy would be recommended for breast cancer treatment but for whom it is contraindicated because of medical reasons (e.g., connective tissue disorder or prior ipsilateral breast radiation) - History of exposure to the following cumulative doses of anthracyclines: doxorubicin > 240 mg/m^2; epirubicin or liposomal doxorubicin-hydrochloride (Myocet) > 480 mg/m^2. For other anthracyclines, exposure equivalent to doxorubicin > 240 mg/m^2 - Cardiopulmonary dysfunction as defined by any of the following: - History of National Cancer Institute (NCI) CTCAE version (v) 5.0 grade >= 3 symptomatic congestive heart failure (CHF) or New York Heart Association (NYHA) criteria class >= II - Angina pectoris requiring anti-anginal medication, serious cardiac arrhythmia not controlled by adequate medication, severe conduction abnormality, or clinically significant valvular disease - High-risk uncontrolled arrhythmias: i.e., atrial tachycardia with a heart rate > 100/min at rest, significant ventricular arrhythmia (ventricular tachycardia) or higher-grade atrioventricular block (AV)-block (second degree AV-block type 2 [Mobitz 2] or third degree AV-block) - Significant symptoms (grade >= 2) relating to left ventricular dysfunction, cardiac arrhythmia, or cardiac ischemia while or since receiving preoperative therapy - History of a decrease in left ventricular ejection fraction (LVEF) to < 40% with prior trastuzumab treatment (e.g., during preoperative therapy) - Uncontrolled hypertension (systolic blood pressure > 180 mmHg and/or diastolic blood pressure > 100 mmHg) - Current severe, uncontrolled systemic disease - Major surgical procedure unrelated to breast cancer or significant traumatic injury within 28 days prior to registration or anticipation of the need for major surgery during the course of study treatment - History of intolerance, including grade 3 to 4 infusion reaction or hypersensitivity to trastuzumab or murine proteins or any components of the product - Peripheral neuropathy of any etiology that exceeds grade 1 - Assessment by the investigator as being unable or unwilling to comply with the requirements of the protocol - Use of a strong CYP3A4 or CYP2C8 inhibitor within 2 weeks, or use of a strong CYP3A4 or CYP2C8 inducer within 5 days prior to registration is prohibited. - Please note that use of sensitive CYP3A substrates should be avoided two weeks before registration and during study treatment. Additionally, CYP3A4 or CYP2C8 inducers are prohibited as concomitant medications within 5 days following discontinuation of tucatinib treatment. Patients who require medications that are known to be sensitive substrates of CYP3A4 with a narrow therapeutic window should be excluded.
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Arm Groups
Arm | Description | Assigned Intervention |
---|---|---|
Active Comparator Arm I (trastuzumab emtansine, placebo) |
Patients receive T-DM1 IV over 30-90 minutes on day 1 and placebo PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. |
|
Experimental Arm II (trastuzumab emtansine, tucatinib) |
Patients receive T-DM1 IV over 30-90 minutes on day 1 and tucatinib PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. |
|
Recruiting Locations
Birmingham 4049979, Alabama 4829764 35233
Fairhope 4061234, Alabama 4829764 36532
Site Public Contact
251-435-4584
Mobile 4076598, Alabama 4829764 36607
Site Public Contact
251-435-3942
Fairbanks 5861897, Alaska 5879092 99701
Gilbert 5295903, Arizona 5551752 85234
Site Public Contact
602-747-9738
Kingman 5301067, Arizona 5551752 86401
Phoenix 5308655, Arizona 5551752 85006
Jonesboro 4116834, Arkansas 4099753 72401
Little Rock 4119403, Arkansas 4099753 72205
Site Public Contact
501-686-8274
Auburn 5325223, California 5332921 95602
Berkeley 5327684, California 5332921 94702
Berkeley 5327684, California 5332921 94704
Beverly Hills 5328041, California 5332921 90211
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Clovis 5338122, California 5332921 93611
Site Public Contact
559-387-1827
Costa Mesa 5339840, California 5332921 92627
Site Public Contact
877-827-8839
Duarte 5344147, California 5332921 91010
Dublin 5344157, California 5332921 94568
Site Public Contact
877-642-4691
Elk Grove 5346111, California 5332921 95758
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Site Public Contact
510-745-6433
Fresno 5350937, California 5332921 93720
Fullerton 5351247, California 5332921 92835
Site Public Contact
714-446-5642
Irvine 5359777, California 5332921 92612
Irvine 5359777, California 5332921 92618
Site Public Contact
877-467-3411
Los Angeles 5368361, California 5332921 90020
Site Public Contact
213-388-0908
Los Angeles 5368361, California 5332921 90033
Los Angeles 5368361, California 5332921 90033
Site Public Contact
323-865-0451
Los Angeles 5368361, California 5332921 90048
Site Public Contact
310-423-8965
Modesto 5373900, California 5332921 95355
Modesto 5373900, California 5332921 95356
Mountain View 5375480, California 5332921 94040
Newport Beach 5376890, California 5332921 92660
Site Public Contact
877-467-3411
Oakland 5378538, California 5332921 94611
Orange 5379513, California 5332921 92868
Site Public Contact
714-734-6220
Orange 5379513, California 5332921 92868
Palm Springs 5380668, California 5332921 92262
Site Public Contact
760-416-4730
Palo Alto 5380748, California 5332921 94301
Palo Alto 5380748, California 5332921 94304
Pasadena 5381396, California 5332921 91105
Site Public Contact
626-535-2420
Rancho Mirage 5386015, California 5332921 92270
Site Public Contact
760-834-3798
Rocklin 5388319, California 5332921 95765
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sacramento 5389489, California 5332921 95814
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95823
Salinas 5391295, California 5332921 93901
San Francisco 5391959, California 5332921 94110
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94158
San Jose 5392171, California 5332921 95119
San Jose 5392171, California 5332921 95124
San Leandro 5392263, California 5332921 94577
San Mateo 5392423, California 5332921 94402
San Rafael 5392567, California 5332921 94903
Santa Clara 5393015, California 5332921 95051
Santa Cruz 5393052, California 5332921 95065
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Site Public Contact
707-521-3830
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95405
Site Public Contact
707-521-3830
South Pasadena 5397717, California 5332921 91030
South San Francisco 5397765, California 5332921 94080
St. Helena 5390267, California 5332921 94574
Site Public Contact
707-967-3698
Sunnyvale 5400075, California 5332921 94086
Torrance 5403022, California 5332921 90503
Site Public Contact
877-467-3411
Torrance 5403022, California 5332921 90505
Upland 5404915, California 5332921 91786
Vallejo 5405380, California 5332921 94589
Vallejo 5405380, California 5332921 94589
Walnut Creek 5406990, California 5332921 94596
Walnut Creek 5406990, California 5332921 94598
Woodland 5410430, California 5332921 95695
Aurora 5412347, Colorado 5417618 80012
Aurora 5412347, Colorado 5417618 80045
Site Public Contact
720-848-0650
Boulder 5574991, Colorado 5417618 80304
Centennial 5416541, Colorado 5417618 80112
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80909
Site Public Contact
719-365-2406
Colorado Springs 5417598, Colorado 5417618 80920
Site Public Contact
719-364-6700
Denver 5419384, Colorado 5417618 80206
Denver 5419384, Colorado 5417618 80218
Denver 5419384, Colorado 5417618 80218
Denver 5419384, Colorado 5417618 80220
Edwards 5420885, Colorado 5417618 81632
Site Public Contact
970-569-7429
Fort Collins 5577147, Colorado 5417618 80524
Site Public Contact
970-297-6150
Fort Collins 5577147, Colorado 5417618 80528
Golden 5423294, Colorado 5417618 80401
Grand Junction 5423573, Colorado 5417618 81505
Greeley 5577592, Colorado 5417618 80631
Greeley 5577592, Colorado 5417618 80631
Highlands Ranch 5425043, Colorado 5417618 80129
Site Public Contact
720-848-0650
Littleton 5429032, Colorado 5417618 80120
Lone Tree 5429208, Colorado 5417618 80124
Lone Tree 5429208, Colorado 5417618 80124
Longmont 5579276, Colorado 5417618 80501
Loveland 5579368, Colorado 5417618 80538
Site Public Contact
970-203-7083
Loveland 5579368, Colorado 5417618 80539
Bridgeport 5282804, Connecticut 4831725 06606
Site Public Contact
860-972-4700
Danbury 4832353, Connecticut 4831725 06810
Site Public Contact
203-739-8074
Fairfield 4834157, Connecticut 4831725 06824
Glastonbury 4835003, Connecticut 4831725 06033
Hartford 4835797, Connecticut 4831725 06102
Site Public Contact
860-545-5363
Hartford 4835797, Connecticut 4831725 06105
Meriden 4838524, Connecticut 4831725 06451
Site Public Contact
866-662-5678
New Britain 4839292, Connecticut 4831725 06050
Site Public Contact
860-224-5660
New Haven 4839366, Connecticut 4831725 06520
North Haven 4839704, Connecticut 4831725 06473
Norwalk 4839822, Connecticut 4831725 06856
Torrington 4844309, Connecticut 4831725 06790
Trumbull 4844459, Connecticut 4831725 06611
Waterbury 4845193, Connecticut 4831725 06708
Waterford 8480031, Connecticut 4831725 06385
Frankford 4142601, Delaware 4142224 19945
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Rehoboth Beach 4144284, Delaware 4142224 19971
Washington D.C. 4140963, District of Columbia 4138106 20002
Site Public Contact
301-548-5743
Washington D.C. 4140963, District of Columbia 4138106 20007
Site Public Contact
202-444-2223
Washington D.C. 4140963, District of Columbia 4138106 20010
Site Public Contact
202-877-8839
Washington D.C. 4140963, District of Columbia 4138106 20016
Altamonte Springs 4145941, Florida 4155751 32701
Site Public Contact
407-303-2200
Aventura 4146429, Florida 4155751 33180
Aventura 4146429, Florida 4155751 33180
Site Public Contact
954-461-2180
Boca Raton 4148411, Florida 4155751 33486
Site Public Contact
561-955-4800
Clearwater 4151316, Florida 4155751 33756
Site Public Contact
855-314-8646
Coral Gables 4151871, Florida 4155751 33146
Site Public Contact
305-243-2647
Deerfield Beach 4153071, Florida 4155751 33442
Site Public Contact
305-243-2647
Fort Lauderdale 4155966, Florida 4155751 33308
Miami 4164138, Florida 4155751 33136
Site Public Contact
305-243-2647
Miami 4164138, Florida 4155751 33176
Site Public Contact
305-243-2647
Miami Beach 4164143, Florida 4155751 33140
Orlando 4167147, Florida 4155751 32803
Orlando 4167147, Florida 4155751 32806
Pensacola 4168228, Florida 4155751 32504
Plantation 4168782, Florida 4155751 33324
Site Public Contact
305-243-2647
Safety Harbor 4170797, Florida 4155751 34695
St. Petersburg 4171563, Florida 4155751 33705
Tampa 4174757, Florida 4155751 33606
Tampa 4174757, Florida 4155751 33607
Albany 4179320, Georgia 4197000 31701
Athens 4180386, Georgia 4197000 30607
Atlanta 4180439, Georgia 4197000 30303
Site Public Contact
404-489-9164
Atlanta 4180439, Georgia 4197000 30308
Site Public Contact
888-946-7447
Atlanta 4180439, Georgia 4197000 30322
Site Public Contact
404-778-1868
Atlanta 4180439, Georgia 4197000 30342
Site Public Contact
404-851-7115
Atlanta 4180439, Georgia 4197000 30342
Augusta 4180531, Georgia 4197000 30901
Site Public Contact
706-821-2944
Augusta 4180531, Georgia 4197000 30909
Site Public Contact
706-736-1830
Decatur 4191124, Georgia 4197000 30033
Site Public Contact
404-321-6111
Duluth 4192289, Georgia 4197000 30096
Lawrenceville 4205196, Georgia 4197000 30046
Newnan 4212684, Georgia 4197000 30265
Site Public Contact
770-400-6629
Savannah 4221552, Georgia 4197000 31404
Savannah 4221552, Georgia 4197000 31405
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Site Public Contact
808-532-0315
Honolulu 5856195, Hawaii 5855797 96813
Site Public Contact
808-545-8548
Honolulu 5856195, Hawaii 5855797 96813
Site Public Contact
808-522-4333
Honolulu 5856195, Hawaii 5855797 96817
Site Public Contact
808-531-8521
Honolulu 5856195, Hawaii 5855797 96819
Honolulu 5856195, Hawaii 5855797 96826
Site Public Contact
808-983-6090
‘Aiea 5856430, Hawaii 5855797 96701
‘Aiea 5856430, Hawaii 5855797 96701
Site Public Contact
808-486-6000
Boise 5586437, Idaho 5596512 83706
Caldwell 5587698, Idaho 5596512 83605
Coeur d'Alene 5589173, Idaho 5596512 83814
Nampa 5601933, Idaho 5596512 83687
Post Falls 5604353, Idaho 5596512 83854
Sandpoint 5606401, Idaho 5596512 83864
Arlington Heights 4883555, Illinois 4896861 60005
Site Public Contact
847-618-4968
Aurora 4883817, Illinois 4896861 60504
Barrington 4884116, Illinois 4896861 60010
Site Public Contact
847-842-4847
Bloomington 4885164, Illinois 4896861 61704
Carterville 4235311, Illinois 4896861 62918
Centralia 4235587, Illinois 4896861 62801
Chicago 4887398, Illinois 4896861 60608
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60612
Site Public Contact
312-864-5204
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Site Public Contact
312-355-3046
Chicago 4887398, Illinois 4896861 60637
Chicago 4887398, Illinois 4896861 60657
Site Public Contact
773-296-5360
Crystal Lake 4889229, Illinois 4896861 60014
Danville 4889426, Illinois 4896861 61832
Decatur 4236895, Illinois 4896861 62526
DeKalb 4889553, Illinois 4896861 60115
Downers Grove 4890119, Illinois 4896861 60515
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Elgin 4890864, Illinois 4896861 60123
Site Public Contact
847-429-2907
Evanston 4891382, Illinois 4896861 60201
Site Public Contact
847-570-2109
Geneva 4893591, Illinois 4896861 60134
Glenview 4893886, Illinois 4896861 60026
Site Public Contact
847-570-2109
Glenview 4893886, Illinois 4896861 60026
Site Public Contact
312-695-1102
Grayslake 4894465, Illinois 4896861 60030
Site Public Contact
312-695-1102
Harvey 4895298, Illinois 4896861 60426
Hazel Crest 4895416, Illinois 4896861 60429
Site Public Contact
708-799-9995
Highland Park 4895876, Illinois 4896861 60035
Site Public Contact
847-570-2109
Lake Forest 4899012, Illinois 4896861 60045
Libertyville 4899739, Illinois 4896861 60048
Libertyville 4899739, Illinois 4896861 60048
Mattoon 4244099, Illinois 4896861 61938
Mount Vernon 4245152, Illinois 4896861 62864
Site Public Contact
618-242-4600
New Lenox 4903535, Illinois 4896861 60451
O'Fallon 4245926, Illinois 4896861 62269
Oak Lawn 4904365, Illinois 4896861 60453-2699
Site Public Contact
800-323-8622
Orland Park 4904937, Illinois 4896861 60462
Orland Park 4904937, Illinois 4896861 60462
Park Ridge 4905367, Illinois 4896861 60068
Site Public Contact
847-384-3621
Pekin 4905599, Illinois 4896861 61554
Peoria 4905687, Illinois 4896861 61615
Rockford 4907959, Illinois 4896861 61108
Site Public Contact
815-227-2633
Rockford 4907959, Illinois 4896861 61114
Shiloh 4249910, Illinois 4896861 62269
Silvis 4911516, Illinois 4896861 61282
Springfield 4250542, Illinois 4896861 62702
Site Public Contact
217-545-7929
Springfield 4250542, Illinois 4896861 62702
Site Public Contact
800-444-7541
Springfield 4250542, Illinois 4896861 62781
Urbana 4914570, Illinois 4896861 61801
Warrenville 4915525, Illinois 4896861 60555
Yorkville 4917298, Illinois 4896861 60560
Carmel 4255466, Indiana 4921868 46032
Indianapolis 4259418, Indiana 4921868 46202
Indianapolis 4259418, Indiana 4921868 46202
Indianapolis 4259418, Indiana 4921868 46219
Indianapolis 4259418, Indiana 4921868 46227
Indianapolis 4259418, Indiana 4921868 46256
Kokomo 4922388, Indiana 4921868 46904
Michigan City 4923531, Indiana 4921868 46360
Ames 4846834, Iowa 4862182 50010
Site Public Contact
515-956-4132
Ames 4846834, Iowa 4862182 50010
Ankeny 4846960, Iowa 4862182 50023
Site Public Contact
515-282-2921
Boone 4849051, Iowa 4862182 50036
Site Public Contact
515-956-4132
Carroll 4850478, Iowa 4862182 51401
Cedar Rapids 4850751, Iowa 4862182 52402
Site Public Contact
319-297-2900
Cedar Rapids 4850751, Iowa 4862182 52403
Site Public Contact
319-365-4673
Cedar Rapids 4850751, Iowa 4862182 52403
Site Public Contact
319-363-2690
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Site Public Contact
515-241-3305
Council Bluffs 4852832, Iowa 4862182 51503
Site Public Contact
712-322-4136
Council Bluffs 4852832, Iowa 4862182 51503
Creston 4853078, Iowa 4862182 50801
Davenport 4853423, Iowa 4862182 52803
Davenport 4853423, Iowa 4862182 52804
Davenport 4853423, Iowa 4862182 52807
Des Moines 4853828, Iowa 4862182 50309
Site Public Contact
515-241-6727
Des Moines 4853828, Iowa 4862182 50309
Site Public Contact
515-241-3305
Des Moines 4853828, Iowa 4862182 50314
Site Public Contact
515-282-2200
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Site Public Contact
515-241-3305
Fort Dodge 4857486, Iowa 4862182 50501
Site Public Contact
515-956-4132
Fort Dodge 4857486, Iowa 4862182 50501
Site Public Contact
515-574-8302
Jefferson 4862482, Iowa 4862182 50129
Site Public Contact
515-956-4132
Marshalltown 4866371, Iowa 4862182 50158
Site Public Contact
515-956-4132
Sioux City 4876523, Iowa 4862182 51101
West Des Moines 4881346, Iowa 4862182 50266
Chanute 4269392, Kansas 4273857 66720
Dodge City 5445298, Kansas 4273857 67801
El Dorado 4270863, Kansas 4273857 67042
Garden City 5445439, Kansas 4273857 67846
Hays 4272782, Kansas 4273857 67601
Site Public Contact
785-623-5774
Independence 4273359, Kansas 4273857 67301
Kingman 4273978, Kansas 4273857 67068
Lawrence 4274277, Kansas 4273857 66044
Liberal 5445820, Kansas 4273857 67905
Newton 4276248, Kansas 4273857 67114
Olathe 4276614, Kansas 4273857 66061
Overland Park 4276873, Kansas 4273857 66209
Overland Park 4276873, Kansas 4273857 66210
Overland Park 4276873, Kansas 4273857 66211
Parsons 4277011, Kansas 4273857 67357
Pittsburg 4277241, Kansas 4273857 66762
Pittsburg 4277241, Kansas 4273857 66762
Pratt 4277752, Kansas 4273857 67124
Salina 4278890, Kansas 4273857 67401
Salina 4278890, Kansas 4273857 67401
Topeka 4280539, Kansas 4273857 66606
Site Public Contact
785-295-8000
Wellington 4281386, Kansas 4273857 67152
Westwood 4281639, Kansas 4273857 66205
Wichita 4281730, Kansas 4273857 67208
Wichita 4281730, Kansas 4273857 67214
Wichita 4281730, Kansas 4273857 67214
Winfield 4281897, Kansas 4273857 67156
Ashland 4282757, Kentucky 6254925 41101
Site Public Contact
606-327-6499
Corbin 4288656, Kentucky 6254925 40701
Site Public Contact
859-523-1934
Lexington 4297983, Kentucky 6254925 40503
Site Public Contact
859-260-6425
Lexington 4297983, Kentucky 6254925 40509
Lexington 4297983, Kentucky 6254925 40536
Site Public Contact
859-257-3379
Louisville 4299276, Kentucky 6254925 40207
New Orleans 4335045, Louisiana 4331987 70112
Augusta 4957003, Maine 4971068 04330
Site Public Contact
207-626-4855
Biddeford 4958141, Maine 4971068 04005
Brewer 4959233, Maine 4971068 04412
Site Public Contact
800-987-3005
Sanford 4977762, Maine 4971068 04073
Scarborough 4977882, Maine 4971068 04074
South Portland 4979244, Maine 4971068 04106
Topsham 4980927, Maine 4971068 04086
York Village 4983656, Maine 4971068 03909
Site Public Contact
207-351-3777
Annapolis 4347242, Maryland 4361885 21401
Baltimore 4347778, Maryland 4361885 21204
Site Public Contact
443-849-3706
Baltimore 4347778, Maryland 4361885 21215
Baltimore 4347778, Maryland 4361885 21237
Site Public Contact
443-777-7364
Baltimore 4347778, Maryland 4361885 21239
Baltimore 4347778, Maryland 4361885 21244
Site Public Contact
301-816-7218
Baltimore 4347778, Maryland 4361885 21287
Bel Air 4348240, Maryland 4361885 21014
Site Public Contact
443-643-3010
Bethesda 4348599, Maryland 4361885 20889-5600
Site Public Contact
301-319-2100
Cumberland 4352681, Maryland 4361885 21502
Site Public Contact
240-964-1400
Easton 4353962, Maryland 4361885 21601
Gaithersburg 4355843, Maryland 4361885 20879
Site Public Contact
301-816-7218
Kensington 4359760, Maryland 4361885 20895
Site Public Contact
301-816-7218
Largo 4360345, Maryland 4361885 20774
Site Public Contact
301-816-7446
Lutherville 4361379, Maryland 4361885 21093
Site Public Contact
410-847-3000
Olney 4364537, Maryland 4361885 20832
Site Public Contact
855-546-1944
Westminster 4373238, Maryland 4361885 21157
Site Public Contact
410-871-6400
Beverly 4930505, Massachusetts 6254926 01915
Site Public Contact
978-922-3000
Boston 4930956, Massachusetts 6254926 02111
Boston 4930956, Massachusetts 6254926 02118
Site Public Contact
617-638-8265
Boston 4930956, Massachusetts 6254926 02215
Site Public Contact
617-667-9925
Boston 4930956, Massachusetts 6254926 02215
Site Public Contact
877-442-3324
Burlington 4931737, Massachusetts 6254926 01805
Foxborough 4937222, Massachusetts 6254926 02035
Site Public Contact
877-338-7425
Gloucester 4937829, Massachusetts 6254926 01930
Site Public Contact
978-283-4000
Hyannis 4940190, Massachusetts 6254926 02601
Site Public Contact
508-862-5799
Lowell 4942618, Massachusetts 6254926 01854
Milford 4943958, Massachusetts 6254926 01757
Site Public Contact
877-332-4294
Peabody 4946863, Massachusetts 6254926 01960
South Weymouth 4951568, Massachusetts 6254926 02190
Site Public Contact
781-624-5000
Winchester 4955884, Massachusetts 6254926 01890
Ann Arbor 4984247, Michigan 5001836 48106
Ann Arbor 4984247, Michigan 5001836 48109
Site Public Contact
800-865-1125
Battle Creek 4985153, Michigan 5001836 49017
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
Dearborn 4990510, Michigan 5001836 48124
Site Public Contact
248-551-7695
Detroit 4990729, Michigan 5001836 48201
Detroit 4990729, Michigan 5001836 48236
Farmington Hills 4992523, Michigan 5001836 48334
Farmington Hills 4992523, Michigan 5001836 48336
Site Public Contact
248-551-7695
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49009
Lansing 4998830, Michigan 5001836 48912
Livonia 4999837, Michigan 5001836 48154
Muskegon 5003132, Michigan 5001836 49444
Niles 5003514, Michigan 5001836 49120
Site Public Contact
616-391-1230
Norton Shores 5004005, Michigan 5001836 49444
Novi 5004062, Michigan 5001836 48374
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Reed City 5006946, Michigan 5001836 49677
Royal Oak 5007804, Michigan 5001836 48073
Site Public Contact
248-551-7695
Saginaw 5007989, Michigan 5001836 48601
Saginaw 5007989, Michigan 5001836 48604
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Southfield 5010636, Michigan 5001836 48075
Tawas City 5011900, Michigan 5001836 48764
Traverse City 5012495, Michigan 5001836 49684
Troy 5012639, Michigan 5001836 48085
Site Public Contact
248-551-7695
West Branch 5014413, Michigan 5001836 48661
Wyoming 5015618, Michigan 5001836 49519
Ypsilanti 5015688, Michigan 5001836 48106
Ypsilanti 5015688, Michigan 5001836 48197
Bemidji 5017822, Minnesota 5037779 56601
Burnsville 5019767, Minnesota 5037779 55337
Coon Rapids 5022025, Minnesota 5037779 55433
Deer River 5024099, Minnesota 5037779 56636
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Edina 5025264, Minnesota 5037779 55435
Hibbing 5030005, Minnesota 5037779 55746
Site Public Contact
218-786-3308
Maplewood 5036588, Minnesota 5037779 55109
Minneapolis 5037649, Minnesota 5037779 55407
Minneapolis 5037649, Minnesota 5037779 55415
Robbinsdale 5043439, Minnesota 5037779 55422
Rochester 5043473, Minnesota 5037779 55905
Site Public Contact
855-776-0015
Saint Cloud 5044407, Minnesota 5037779 56303
Saint Louis Park 5045021, Minnesota 5037779 55416
Saint Paul 5045360, Minnesota 5037779 55101
Saint Paul 5045360, Minnesota 5037779 55102
Sandstone 5045908, Minnesota 5037779 55072
Shakopee 5046997, Minnesota 5037779 55379
Virginia 5051468, Minnesota 5037779 55792
Columbus 4422442, Mississippi 4436296 39705
Grenada 4428539, Mississippi 4436296 38901
New Albany 4438121, Mississippi 4436296 38652
Oxford 4440076, Mississippi 4436296 38655
Southhaven 4446702, Mississippi 4436296 38671
Ballwin 4375663, Missouri 4398678 63011
Site Public Contact
314-251-7058
Cape Girardeau 4379966, Missouri 4398678 63703
Chesterfield 4381072, Missouri 4398678 63017
Site Public Contact
314-205-6936
City of Saint Peters 4407237, Missouri 4398678 63376
Columbia 4381982, Missouri 4398678 65212
Site Public Contact
573-882-7440
Creve Coeur 4382837, Missouri 4398678 63141
Farmington 4386289, Missouri 4398678 63640
Site Public Contact
314-996-5569
Independence 4391812, Missouri 4398678 64057
Kansas City 4393217, Missouri 4398678 64108
Site Public Contact
816-404-4375
Kansas City 4393217, Missouri 4398678 64111
Kansas City 4393217, Missouri 4398678 64132
Kansas City 4393217, Missouri 4398678 64154
Lee's Summit 4394870, Missouri 4398678 64064
Lee's Summit 4394870, Missouri 4398678 64086
North Kansas City 4400860, Missouri 4398678 64116
Sainte Genevieve 4407294, Missouri 4398678 63670
Site Public Contact
314-996-5569
Springfield 4409896, Missouri 4398678 65807
Site Public Contact
417-269-4520
St Louis 4407066, Missouri 4398678 63110
St Louis 4407066, Missouri 4398678 63128
St Louis 4407066, Missouri 4398678 63129
St Louis 4407066, Missouri 4398678 63131
Site Public Contact
314-996-5569
St Louis 4407066, Missouri 4398678 63136
St Louis 4407066, Missouri 4398678 63141
Site Public Contact
314-251-7066
Sullivan 4410669, Missouri 4398678 63080
Site Public Contact
314-996-5569
Sunset Hills 4410836, Missouri 4398678 63127
Site Public Contact
314-996-5569
Anaconda 5637146, Montana 5667009 59711
Billings 5640350, Montana 5667009 59101
Bozeman 5641727, Montana 5667009 59715
Great Falls 5655240, Montana 5667009 59405
Kalispell 5660340, Montana 5667009 59901
Missoula 5666639, Montana 5667009 59802
Missoula 5666639, Montana 5667009 59804
Omaha 5074472, Nebraska 5073708 68114
Site Public Contact
402-334-4773
Omaha 5074472, Nebraska 5073708 68114
Site Public Contact
402-354-5144
Omaha 5074472, Nebraska 5073708 68114
Henderson 5505411, Nevada 5509151 89052
Las Vegas 5506956, Nevada 5509151 89102
Las Vegas 5506956, Nevada 5509151 89148
Reno 5511077, Nevada 5509151 89502
Concord 5084868, New Hampshire 5090174 03301
Site Public Contact
603-224-2556
Lebanon 5088597, New Hampshire 5090174 03756
Manchester 5089178, New Hampshire 5090174 03103
Site Public Contact
800-339-6484
Berkeley Heights 5095617, New Jersey 5101760 07922
Camden 4501018, New Jersey 5101760 08103
Site Public Contact
856-325-6757
Englewood 5097672, New Jersey 5101760 07631
Site Public Contact
201-894-3456
Florham Park 5098095, New Jersey 5101760 07932
Hackensack 5098706, New Jersey 5101760 07601
Site Public Contact
551-996-2897
Hamilton 5098765, New Jersey 5101760 08690
Site Public Contact
609-631-6946
Jersey City 5099836, New Jersey 5101760 07302
Lakewood 5100280, New Jersey 5101760 08701
Livingston 5100572, New Jersey 5101760 07039
Long Branch 5100619, New Jersey 5101760 07740
Morristown 5101427, New Jersey 5101760 07960
Site Public Contact
973-971-5900
New Brunswick 5101717, New Jersey 5101760 08903
Site Public Contact
732-235-7356
Newark 5101798, New Jersey 5101760 07101
Site Public Contact
732-235-7356
Newark 5101798, New Jersey 5101760 07112
Paterson 5102466, New Jersey 5101760 07503
Somerville 5104774, New Jersey 5101760 08876
Summit 5105127, New Jersey 5101760 07902
Site Public Contact
908-522-2043
Teaneck 5105262, New Jersey 5101760 07666
Site Public Contact
201-833-6312
Toms River 4504476, New Jersey 5101760 08755
Albuquerque 5454711, New Mexico 5481136 87106
Rio Rancho 5487811, New Mexico 5481136 87124
Auburn 5107505, New York 5128638 13021
Site Public Contact
315-472-7504
Bay Shore 5108169, New York 5128638 11706
Site Public Contact
516-734-8896
Buffalo 5110629, New York 5128638 14263
East Hills 5115904, New York 5128638 11548
East Syracuse 5116079, New York 5128638 13057
Site Public Contact
315-472-7504
Glens Falls 5118693, New York 5128638 12801
Site Public Contact
518-926-6700
Jamaica 5122520, New York 5128638 11432
Site Public Contact
718-883-3000
Lake Success 5123853, New York 5128638 11042
Site Public Contact
516-734-8896
Mineola 5127134, New York 5128638 11501
Mount Kisco 5127744, New York 5128638 10549
New York 5128581, New York 5128638 10011
New York 5128581, New York 5128638 10016
New York 5128581, New York 5128638 10019
New York 5128581, New York 5128638 10021
Site Public Contact
516-734-8896
New York 5128581, New York 5128638 10029
New York 5128581, New York 5128638 10032
New York 5128581, New York 5128638 10065
Site Public Contact
212-434-4460
Nyack 5129433, New York 5128638 10960
Site Public Contact
845-348-8507
Poughkeepsie 5132143, New York 5128638 12601
Site Public Contact
845-483-6483
Rochester 5134086, New York 5128638 14642
Site Public Contact
585-275-5830
Sleepy Hollow 5138371, New York 5128638 10591
Site Public Contact
914-366-1600
Stony Brook 5139865, New York 5128638 11794
Site Public Contact
800-862-2215
Syracuse 5140405, New York 5128638 13210
Site Public Contact
315-464-5476
Syracuse 5140405, New York 5128638 13215
Site Public Contact
315-472-7504
Verona 5142333, New York 5128638 13478
West Islip 5143866, New York 5128638 11795
Site Public Contact
516-326-7514
White Plains 5144336, New York 5128638 10601
Asheboro 4453035, North Carolina 4482348 27203
Site Public Contact
336-832-0836
Asheboro 4453035, North Carolina 4482348 27203
Burlington 4458228, North Carolina 4482348 27215
Cary 4459467, North Carolina 4482348 27518
Chapel Hill 4460162, North Carolina 4482348 27599
Charlotte 4460243, North Carolina 4482348 28204
Clinton 4461101, North Carolina 4482348 28328
Durham 4464368, North Carolina 4482348 27710
Site Public Contact
888-275-3853
Garner 4467657, North Carolina 4482348 27529
Gastonia 4467732, North Carolina 4482348 28054
Goldsboro 4468261, North Carolina 4482348 27534
Greensboro 4469146, North Carolina 4482348 27403
Greensboro 4469146, North Carolina 4482348 27410
Hillsborough 4471241, North Carolina 4482348 27278
Huntersville 4472370, North Carolina 4482348 28078
Jacksonville 4473083, North Carolina 4482348 28546
Kernersville 4474221, North Carolina 4482348 27284
Kinston 4474436, North Carolina 4482348 28501
Matthews 4478334, North Carolina 4482348 28105
Mooresville 4480125, North Carolina 4482348 28117
Mount Airy 4480378, North Carolina 4482348 27030
North Wilkesboro 4482577, North Carolina 4482348 28659
Pinehurst 4485272, North Carolina 4482348 28374
Raleigh 4487042, North Carolina 4482348 27607
Site Public Contact
919-785-4878
Raleigh 4487042, North Carolina 4482348 27607
Raleigh 4487042, North Carolina 4482348 27614
Reidsville 4487682, North Carolina 4482348 27320
Stateville, North Carolina 4482348 28625
Thomasville 4494942, North Carolina 4482348 27360
Winston-Salem 4499612, North Carolina 4482348 27103
Bismarck 5688025, North Dakota 5690763 58501
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Belpre 4506187, Ohio 5165418 45714
Canton 5149222, Ohio 5165418 44708
Site Public Contact
888-293-4673
Canton 5149222, Ohio 5165418 44710
Centerville 4508204, Ohio 5165418 45459
Chillicothe 4828890, Ohio 5165418 45601
Cincinnati 4508722, Ohio 5165418 45219
Site Public Contact
513-585-0844
Cincinnati 4508722, Ohio 5165418 45220
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43213
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43215
Columbus 4509177, Ohio 5165418 43219
Columbus 4509177, Ohio 5165418 43228
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Site Public Contact
937-276-8320
Dayton 4509884, Ohio 5165418 45415
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Franklin 4512203, Ohio 5165418 45005-1066
Greenville 5156493, Ohio 5165418 45331
Site Public Contact
937-569-7515
Grove City 4513409, Ohio 5165418 43123
Mansfield 5161723, Ohio 5165418 44903
Marietta 4517586, Ohio 5165418 45750
Marion 5161902, Ohio 5165418 43302
Marysville 5162077, Ohio 5165418 43040
Newark 5164466, Ohio 5165418 43055
Portsmouth 4521816, Ohio 5165418 45662
Springfield 4525353, Ohio 5165418 45504
Steubenville 5173048, Ohio 5165418 43952
Site Public Contact
888-874-7000
Sylvania 5173572, Ohio 5165418 43560
Toledo 5174035, Ohio 5165418 43623
Site Public Contact
800-444-3561
Troy 5174358, Ohio 5165418 45373
Zanesville 4528923, Ohio 5165418 43701
Lawton 4540737, Oklahoma 4544379 73505
Site Public Contact
877-231-4440
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73120
Site Public Contact
405-752-3402
Oklahoma City 4544349, Oklahoma 4544379 73142
Site Public Contact
405-773-6613
Bend 5713587, Oregon 5744337 97701
Gresham 5729485, Oregon 5744337 97030
Site Public Contact
503-413-2150
Newberg 5742726, Oregon 5744337 97132
Ontario 5744166, Oregon 5744337 97914
Oregon City 5744253, Oregon 5744337 97045
Portland 5746545, Oregon 5744337 97210
Portland 5746545, Oregon 5744337 97213
Portland 5746545, Oregon 5744337 97225
Tualatin 5757506, Oregon 5744337 97062
Site Public Contact
503-413-1742
Allentown 5178127, Pennsylvania 6254927 18103
Altoona 5178195, Pennsylvania 6254927 16601
Beaver 5179446, Pennsylvania 6254927 15009
Bethlehem 5180225, Pennsylvania 6254927 18017
Broomall 4556802, Pennsylvania 6254927 19008
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Butler 5182534, Pennsylvania 6254927 16001
Carlisle 5183234, Pennsylvania 6254927 17015
Chambersburg 4557109, Pennsylvania 6254927 17201
Site Public Contact
717-217-6020
Cranberry Township 8643098, Pennsylvania 6254927 16066
Danville 5186327, Pennsylvania 6254927 17822
Drexel Hill 4557606, Pennsylvania 6254927 19026
Ephrata 5188815, Pennsylvania 6254927 17522
Site Public Contact
717-721-4840
Erie 5188843, Pennsylvania 6254927 16505
Farrell 5189377, Pennsylvania 6254927 16121
Gettysburg 4558183, Pennsylvania 6254927 17325
Site Public Contact
877-441-7957
Glen Mills 4558229, Pennsylvania 6254927 19342
Site Public Contact
610-284-8237
Greensburg 5192029, Pennsylvania 6254927 15601
Site Public Contact
724-838-1900
Greenville 5192019, Pennsylvania 6254927 16125
Hanover 4558475, Pennsylvania 6254927 17331
Site Public Contact
717-632-1559
Harrisburg 5192726, Pennsylvania 6254927 17109
Hazleton 5193011, Pennsylvania 6254927 18201
Indiana 5194868, Pennsylvania 6254927 15701
Johnstown 5195561, Pennsylvania 6254927 15901
Site Public Contact
814-534-4724
Lebanon 5197517, Pennsylvania 6254927 17042
Lewisburg 5197842, Pennsylvania 6254927 17837
McKeesport 5200499, Pennsylvania 6254927 15132
Site Public Contact
412-647-8073
Mechanicsburg 5200657, Pennsylvania 6254927 17050
Media 4559575, Pennsylvania 6254927 19063
Monroeville 5201734, Pennsylvania 6254927 15146
Moon Township 5201821, Pennsylvania 6254927 15108
Mount Pleasant 5202281, Pennsylvania 6254927 15666
New Castle 5203127, Pennsylvania 6254927 16105
North Huntingdon, Pennsylvania 6254927 15642
Paoli 5205037, Pennsylvania 6254927 19301
Philadelphia 4560349, Pennsylvania 6254927 19104
Philadelphia 4560349, Pennsylvania 6254927 19107
Philadelphia 4560349, Pennsylvania 6254927 19111
Site Public Contact
215-728-4790
Philadelphia 4560349, Pennsylvania 6254927 19114
Philadelphia 4560349, Pennsylvania 6254927 19140
Site Public Contact
215-728-2983
Phoenixville 5205849, Pennsylvania 6254927 19460
Site Public Contact
610-983-1800
Pittsburgh 5206379, Pennsylvania 6254927 15213
Site Public Contact
412-647-2811
Pittsburgh 5206379, Pennsylvania 6254927 15215
Site Public Contact
412-784-4900
Pittsburgh 5206379, Pennsylvania 6254927 15219
Site Public Contact
800-533-8762
Pittsburgh 5206379, Pennsylvania 6254927 15232
Site Public Contact
412-647-8073
Pittsburgh 5206379, Pennsylvania 6254927 15237
Site Public Contact
412-367-6454
Pittsburgh 5206379, Pennsylvania 6254927 15243
Site Public Contact
412-502-3920
Pottstown 5207069, Pennsylvania 6254927 19464
Site Public Contact
610-327-7544
Pottsville 5207080, Pennsylvania 6254927 17901
Sayre 5211037, Pennsylvania 6254927 18840
Site Public Contact
800-836-0388
Scranton 5211303, Pennsylvania 6254927 18510
Seneca 5211432, Pennsylvania 6254927 16346
Site Public Contact
814-676-7900
Uniontown 4561859, Pennsylvania 6254927 15401
Upland 4561874, Pennsylvania 6254927 19013
Washington 5218069, Pennsylvania 6254927 15301
West Mifflin 5218802, Pennsylvania 6254927 15122
Site Public Contact
412-653-8100
West Reading 5218867, Pennsylvania 6254927 19611
Site Public Contact
610-988-9323
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Williamsport 5219585, Pennsylvania 6254927 17701
Site Public Contact
800-598-4282
Williamsport 5219585, Pennsylvania 6254927 17754
Willow Grove 5219619, Pennsylvania 6254927 19090
Wynnewood 5220230, Pennsylvania 6254927 19096
York 4562407, Pennsylvania 6254927 17403
Site Public Contact
717-741-9229
York 4562407, Pennsylvania 6254927 17403
Site Public Contact
877-441-7957
York 4562407, Pennsylvania 6254927 17403
Site Public Contact
877-441-7957
York 4562407, Pennsylvania 6254927 17408
Site Public Contact
717-724-6760
Providence 5224151, Rhode Island 5224323 02903
Site Public Contact
401-444-1488
Providence 5224151, Rhode Island 5224323 02905
Site Public Contact
401-274-1122
Warwick 5225507, Rhode Island 5224323 02886
Site Public Contact
401-737-7010
Beaufort 4570284, South Carolina 4597040 29902
Bluffton 4571722, South Carolina 4597040 29910
Boiling Springs 4571805, South Carolina 4597040 29316
Site Public Contact
864-241-6251
Charleston 4574324, South Carolina 4597040 29425
Easley 4577263, South Carolina 4597040 29640
Gaffney 4579418, South Carolina 4597040 29341
Georgetown 4579662, South Carolina 4597040 29440
Greenville 4580543, South Carolina 4597040 29601
Greenville 4580543, South Carolina 4597040 29605
Site Public Contact
864-241-6251
Greenville 4580543, South Carolina 4597040 29605
Site Public Contact
864-241-6251
Greenville 4580543, South Carolina 4597040 29607
Greenville 4580543, South Carolina 4597040 29615
Site Public Contact
864-241-6251
Greer 4580599, South Carolina 4597040 29650
Site Public Contact
864-241-6251
Greer 4580599, South Carolina 4597040 29651
Hilton Head Island 4581832, South Carolina 4597040 29926-3827
Seneca 4595346, South Carolina 4597040 29672
Site Public Contact
864-241-6251
Spartanburg 4597200, South Carolina 4597040 29303
Union 4599214, South Carolina 4597040 29379
West Columbia 4600541, South Carolina 4597040 29169
Aberdeen 5225857, South Dakota 5769223 57401
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57105
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Yankton 5233053, South Dakota 5769223 57078
Alcoa 4602181, Tennessee 4662168 37701
Collierville 4614748, Tennessee 4662168 38017
Kingsport 4634662, Tennessee 4662168 37660
Knoxville 4634946, Tennessee 4662168 37920
Site Public Contact
865-544-9773
Memphis 4641239, Tennessee 4662168 38120
Nashville 4644585, Tennessee 4662168 37204
Site Public Contact
800-811-8480
Amarillo 5516233, Texas 4736286 79106
Dallas 4684888, Texas 4736286 75235
Dallas 4684888, Texas 4736286 75237
Dallas 4684888, Texas 4736286 75390
Galveston 4692883, Texas 4736286 77555-0565
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Site Public Contact
713-873-2000
Houston 4699066, Texas 4736286 77030
Site Public Contact
713-790-2700
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77070
Nassau Bay 4713813, Texas 4736286 77058
Richardson 4722625, Texas 4736286 75080
Sugar Land 4734825, Texas 4736286 77479
Site Public Contact
281-242-2873
The Woodlands 4736476, Texas 4736286 77385
Bristol 4748993, Virginia 6254928 24201
Burke 4749950, Virginia 6254928 22015
Chesapeake 4752186, Virginia 6254928 23320
Fairfax 4758023, Virginia 6254928 22031
Fairfax 4758023, Virginia 6254928 22033
Gloucester 4761161, Virginia 6254928 23061
Lynchburg 4771075, Virginia 6254928 24501
McLean 4772354, Virginia 6254928 22102
Site Public Contact
240-632-4284
Mechanicsville 4772566, Virginia 6254928 23116
Midlothian 4772943, Virginia 6254928 23114
Newport News 4776024, Virginia 6254928 23601
Richmond 4781708, Virginia 6254928 23226
Richmond 4781708, Virginia 6254928 23229
Richmond 4781708, Virginia 6254928 23230
Richmond 4781708, Virginia 6254928 23235
Richmond 4781708, Virginia 6254928 23298
South Hill 4786619, Virginia 6254928 23970
Suffolk 4788158, Virginia 6254928 23435
Virginia Beach 4791259, Virginia 6254928 23454
Williamsburg 4793846, Virginia 6254928 23185
Woodbridge 4794457, Virginia 6254928 22192
Auburn 5785965, Washington 5815135 98001
Bremerton 5788054, Washington 5815135 98310
Edmonds 5793427, Washington 5815135 98026
Gig Harbor 5795440, Washington 5815135 98335
Issaquah 5798487, Washington 5815135 98029
Kennewick 5799610, Washington 5815135 99336
Puyallup 5807575, Washington 5815135 98372
Renton 5808189, Washington 5815135 98055
Seattle 5809844, Washington 5815135 98122
Spokane 5811696, Washington 5815135 99204
Spokane 5811696, Washington 5815135 99218
Tacoma 5812944, Washington 5815135 98405
Vancouver 5814616, Washington 5815135 98664
Vancouver 5814616, Washington 5815135 98684
Vancouver 5814616, Washington 5815135 98686
Site Public Contact
503-413-2150
Charleston 4801859, West Virginia 4826850 25304
Site Public Contact
304-388-9944
Huntington 4809537, West Virginia 4826850 25701
Antigo 5244010, Wisconsin 5279468 54409
Appleton 5244080, Wisconsin 5279468 54911
Appleton 5244080, Wisconsin 5279468 54915
Ashland 5244247, Wisconsin 5279468 54806
Brookfield 5246835, Wisconsin 5279468 53045
Burlington 5247214, Wisconsin 5279468 53105
Chilton 5248469, Wisconsin 5279468 53014
Eau Claire 5251436, Wisconsin 5279468 54701
Eau Claire 5251436, Wisconsin 5279468 54701
Franklin 5253710, Wisconsin 5279468 53132
Germantown 5254218, Wisconsin 5279468 53022
Grafton 5254739, Wisconsin 5279468 53024
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54303
Green Bay 5254962, Wisconsin 5279468 54311
Janesville 5257754, Wisconsin 5279468 53548
Johnson Creek 5257996, Wisconsin 5279468 53038
Kenosha 5258393, Wisconsin 5279468 53142
La Crosse 5258957, Wisconsin 5279468 54601
Madison 5261457, Wisconsin 5279468 53792
Marinette 5261852, Wisconsin 5279468 54143
Marshfield 5261969, Wisconsin 5279468 54449
Medford 5262475, Wisconsin 5279468 54451
Menomonee Falls 5262630, Wisconsin 5279468 53051
Site Public Contact
262-257-5100
Mequon 5262649, Wisconsin 5279468 53097
Milwaukee 5263045, Wisconsin 5279468 53209
Milwaukee 5263045, Wisconsin 5279468 53211
Milwaukee 5263045, Wisconsin 5279468 53215
Milwaukee 5263045, Wisconsin 5279468 53226
Site Public Contact
414-805-3666
Milwaukee 5263045, Wisconsin 5279468 53233
Minocqua 5263156, Wisconsin 5279468 54548
Mukwonago 5263965, Wisconsin 5279468 53149
Neenah 5264223, Wisconsin 5279468 54956
Oak Creek 5265228, Wisconsin 5279468 53154
Site Public Contact
414-805-0505
Oconomowoc 5265499, Wisconsin 5279468 53066
Site Public Contact
262-928-7878
Oconto Falls 5265522, Wisconsin 5279468 54154
Oshkosh 5265838, Wisconsin 5279468 54904
Oshkosh 5265838, Wisconsin 5279468 54904
Racine 5268249, Wisconsin 5279468 53405
Racine 5268249, Wisconsin 5279468 53406
Rhinelander 5268720, Wisconsin 5279468 54501
Rice Lake 5268798, Wisconsin 5279468 54868
Sheboygan 5272893, Wisconsin 5279468 53081
Stevens Point 5274644, Wisconsin 5279468 54481
Stevens Point 5274644, Wisconsin 5279468 54482
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Summit, Wisconsin 5279468 53066
Two Rivers 5276609, Wisconsin 5279468 54241
Waukesha 5278052, Wisconsin 5279468 53188
Site Public Contact
262-928-7632
Waukesha 5278052, Wisconsin 5279468 53188
Waupaca 5278083, Wisconsin 5279468 54981
Wausau 5278120, Wisconsin 5279468 54401
Site Public Contact
877-405-6866
Wauwatosa 5278159, Wisconsin 5279468 53226
Wauwatosa 5278159, Wisconsin 5279468 53226
West Allis 5278420, Wisconsin 5279468 53227
West Bend 5278422, Wisconsin 5279468 53095
Site Public Contact
414-805-0505
Weston 5278693, Wisconsin 5279468 54476
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Site Public Contact
715-422-7718
Bayamón 4562831, Puerto Rico 00959-5060
Site Public Contact
787-395-7085
Bayamón 4562831, Puerto Rico 00961
Site Public Contact
787-780-2865
Manatí 4566137, Puerto Rico 00674
Site Public Contact
787-621-4397
San Juan 4568127, Puerto Rico 00917
Site Public Contact
787-274-3387
San Juan 4568127, Puerto Rico 00927
San Juan 4568127, Puerto Rico 00936
Site Public Contact
787-763-1296
More Details
- NCT ID
- NCT04457596
- Status
- Recruiting
- Sponsor
- Alliance for Clinical Trials in Oncology
Detailed Description
PRIMARY OBJECTIVE: I. To determine if the invasive disease-free survival (iDFS) with T-DM1 and tucatinib is superior to the iDFS in the control arm (T-DM1 + placebo) when administered to high risk patients with HER2-positive breast cancer and residual disease after neoadjuvant HER2-directed therapy. SECONDARY OBJECTIVES: I. To evaluate whether treatment with tucatinib plus T-DM1 compared to treatment with T-DM1 alone (T-DM1 plus placebo) improves the following: Ia. Breast cancer free survival (BCFS). Ib. Distant recurrence-free survival (DRFS). Ic. Brain metastases-free survival (BMFS). Id. Overall survival (OS). II. To evaluate whether treatment with tucatinib plus T-DM1 compared to treatment with T-DM1 alone (T-DM1 plus placebo) reduces the incidence of brain metastases. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive T-DM1 intravenously (IV) over 30-90 minutes on day 1 and placebo orally (PO) twice daily (BID) on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive T-DM1 IV over 30-90 minutes on day 1 and tucatinib PO BID on days 1-21. Treatment repeats every 21 days for up to 14 cycles in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up at 30 days, then every 6 months for 10 years.