Purpose

The primary purpose of the Research Sample Repository is to make blood samples available for research studies related to histocompatibility and hematopoietic cell transplantation (HCT) or other cellular therapy. Representatives of participating centers and investigators or research groups may request access to research samples contained in the Research Sample Repository for the purpose of conducting research including: - investigating molecular explanations for histocompatibility or clinical outcomes through analysis of genomic, epigenetic, or other biomolecular data - evaluating the factors that affect transplant or cellular therapy outcome - studying the distribution of HLA tissue types in different populations - studying the success of transplantation, cellular therapies or supportive care in the management of marrow toxic injuries - performing de-linked (anonymous) research

Conditions

Eligibility

Eligible Ages
All ages
Eligible Sex
All
Accepts Healthy Volunteers
No

Criteria

Eligibility to participate in the Research Sample Repository Protocol:

Hematopoietic Cell (HC) or Other Cellular Therapy Donors

- Donors are eligible to participate in the Research Sample Repository if they have
donated or are scheduled to donate HCs or cellular therapy products to an allogeneic
recipient either by a marrow harvest or by apheresis. This includes adults with and
without decision making capacity and children.

- All donors registered on the National Marrow Donor Program (NMDP) Registry,
regardless of whether they have been requested to donate a product for a patient,
are eligible to participate in the Research Sample Repository.

Cord Blood Units (CBUs)

- Testable material from CBUs (Specimens) infused at treatment centers covered under
the C. W. Bill Young Transplantation Program are eligible for inclusion in the
Research Sample Repository. Material may be submitted by participating treatment
centers, centralized laboratories and Cord Blood Banks.

Hematopoietic Cell Transplantation or Other Cellular Therapy Recipients

- All U.S. recipients of allogeneic or autologous HC transplants or cellular therapies
are eligible to participate in the Research Sample Repository. This includes adults
with and without decision making capacity and children.

Patients with Marrow Toxic Injury

- Any patient who is treated for a marrow toxic injury at a center participating in
the NMDP's Radiation Injury Treatment Network (RITN) is eligible to participate in
the Research Sample Repository. This includes adults with and without
decision-making capacity and children.

- Eligible patients may have received support care only, growth factor support,
hematopoietic stem cell transplant or other appropriate medical treatment for marrow
toxic injury

Study Design

Phase
Study Type
Observational
Observational Model
Case-Only
Time Perspective
Retrospective

Recruiting Locations

NMDP Biorepository
New Brighton, Minnesota 55112
Contact:
Liz Weideman
651-745-5036
ewiedenm@nmdp.org

More Details

NCT ID
NCT04920474
Status
Recruiting
Sponsor
Center for International Blood and Marrow Transplant Research

Study Contact

Ashley Spahn
RepositoryIRB@NMDP.ORG

Detailed Description

Research samples will be accepted from the following four categories: - Hematopoietic Cell or other Cellular Therapy Donors - Cord Blood Units - Hematopoietic Cell Transplantation or other Cellular Therapy Recipients - Patients with Marrow Toxic Injury

Notice

Study information shown on this site is derived from ClinicalTrials.gov (a public registry operated by the National Institutes of Health). The listing of studies provided is not certain to be all studies for which you might be eligible. Furthermore, study eligibility requirements can be difficult to understand and may change over time, so it is wise to speak with your medical care provider and individual research study teams when making decisions related to participation.