Comparing Cisplatin Every Three Weeks to Cisplatin Weekly When Combined With Radiation for Patients With Advanced Head and Neck Cancer
Purpose
This phase II/III trial compares whether cisplatin given weekly with radiation therapy is better tolerated than cisplatin given every three weeks with radiation therapy for the treatment of head and neck cancer that has spread to other places in the body (advanced). The second part of this study will also help to find out if the cisplatin given weekly approach will extend patients' life by at least the same amount of time as the cisplatin given every three weeks approach. Cisplatin is in a class of medications known as platinum-containing compounds that work by killing, stopping or slowing the growth of cancer cells. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Radiation with low-dose cisplatin given weekly may be effective in shrinking or stabilizing head and neck cancer or preventing its recurrence.
Conditions
- Advanced Head and Neck Squamous Cell Carcinoma
- Advanced Hypopharyngeal Squamous Cell Carcinoma
- Advanced Laryngeal Squamous Cell Carcinoma
- Advanced Oropharyngeal Squamous Cell Carcinoma
- Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8
- Stage III Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
- Stage III Oropharyngeal (p16-Negative) Carcinoma AJCC v8
- Stage IV Head and Neck Cutaneous Squamous Cell Carcinoma AJCC v8
- Stage IV Oropharyngeal (p16-Negative) Carcinoma AJCC v8
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Pathologically (histologically or cytologically) proven diagnosis of SCCHN of the oropharynx, larynx, hypopharynx, or p16-positive unknown primary prior to registration; specimen from cervical lymph nodes with a well-defined primary site documented clinically or radiologically is acceptable; in patients with carcinoma of unknown primary this will be sufficient for pathologic confirmation without a clinically or radiographically defined primary site - For patients with oropharyngeal cancer (OPC)/cancer of unknown primary (CUP): P16 status based on local site immunohistochemical tissue staining is required. A cell block obtained from a fine needle aspiration (FNA) biopsy specimen may be used as the sole diagnostic tissue. Centers are encouraged to contact the pathology chair for clarification. - Note: Institutions must screen patients for p16 status by immunohistochemistry (IHC) in order to be eligible for the trial using a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory. A rigorous laboratory accreditation process similar to the United States (U.S.) CLIA certification, such as the provincial accreditation status offered by the Ontario Laboratory Accreditation (OLA) Program in Canada, the College of American Pathologists (CAP), or an equivalent accreditation in other countries, is acceptable. - The p16 results must be reported on the pathology report being submitted. The p16 positivity is defined as > 70% of tumor cells showing strong nuclear and/or cytoplasmic immunostaining with p16 antibody. - For patients with laryngeal and hypopharyngeal primaries: Analysis of p16 status is NOT required. - Patients must have clinically or radiographically evident measurable disease at the primary site or at nodal stations. Simple tonsillectomy or local excision of the primary without removal of nodal disease is permitted, as is excision removing gross nodal disease but with intact primary site. Limited neck dissections retrieving =< 4 nodes are permitted and considered as non-therapeutic nodal excisions - Clinical stage (American Joint Committee on Cancer [AJCC], 8th ed.), including no distant metastases based on the following diagnostic workup: - History/physical examination within 60 days prior to registration - One of the following imaging studies is required within 60 days prior to registration: - Computed tomography (CT) scan of neck (diagnostic quality with contrast, unless contraindicated) OR - Magnetic resonance imaging (MRI) of the neck (diagnostic quality with contrast, unless contraindicated) OR - Fludeoxyglucose F-18 (FDG)-positron emission tomography (PET)/CT of the neck; the CT component must be of diagnostic quality with contrast, unless contraindicated. - Note: A diagnostic quality CT or MRI with contrast or FDG-PET/CT scan of neck performed for the purposes of radiation planning may serve as both staging and planning tools - One of the following imaging studies is required within 60 days prior to registration: - FDG-PET/CT of the chest; FDG-PET/CT scan is strongly preferred and highly recommended to be used for eligibility OR - Chest CT - Exam with laryngopharyngoscopy (mirror or in office direct procedure acceptable) within 70 days prior to registration; - Eligibility by patient cohort; - Non-OPC/p16-negative OPC Cohort; Tumor Site: Larynx/Hypopharynx; Clinical Staging (AJCC, 8th ed.): T3-4 N0 or T1-4 N1-3 T2 N0 (hypopharynx only) - Tumor Site: p16-negative OPC; Clinical Staging (AJCC, 8th ed.): T2N1, T1-4 N2-3, or T3-4 N0-1 - p16-positive OPC/CUP Cohort; - Tumor Site: OPC; Smoking Status: =< 10 pack-years; Clinical Staging (AJCC, 8th ed.): T1-3 N2-3 or T4 N0-3 - Tumor Site: OPC; Smoking Status: > 10 pack-years; Clinical Staging (AJCC, 8th ed.): T1N2-3, T2N1-3, or T3-4 N0-3 - Tumor Site: CUP; Smoking Status: Any; Clinical Staging (AJCC, 8th ed.): T0 N2-3 Note: Cigar and pipe tobacco consumption is not included in calculating the lifetime pack-years. Marijuana consumption is likewise not considered in this calculation. There is also no clear scientific evidence regarding the role of chewing tobacco-containing products in oropharyngeal cancer, although this is possibly more concerning given the proximity of the oral cavity and oropharynx. In any case, investigators should not count use of non-cigarette tobacco products in the pack-years calculation. - Age >= 18 - Zubrod (Eastern Cooperative Oncology Group [ECOG]) performance status of 0-1 within 14 days prior to registration - Absolute neutrophil count (ANC) >= 1,500 cells/mm^3 (within 30 days prior to registration) - Platelets >= 75,000 cells/mm^3 (within 30 days prior to registration) - Hemoglobin >= 8.0 g/dL (within 30 days prior to registration) - Note: The use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 8.0 g/dL is acceptable) - Calculated creatinine clearance (CrCl) >= 50 mL/min by the Cockcroft-Gault formula (within 30 days prior to registration) - Total bilirubin =< 1.5 x institutional upper limit of normal (ULN) (within 30 days prior to registration) (not applicable to patients with known Gilbert's syndrome) - Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) =< 1.5 x institutional ULN (within 30 days prior to registration) - Known human immunodeficiency virus (HIV) infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months and CD4 T Cell count > 200 cells/mm^3 are eligible for this trial. Testing is not required for entry into protocol - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial - Negative urine or serum pregnancy test (in persons of childbearing potential) within 14 days prior to registration. Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal. Menopause is defined clinically as 12 months of amenorrhea in a woman over 45 in the absence of other biological or physiological causes - Willing to use highly effective contraceptives for participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) during therapy and for 14 months (females); for 11 months (males) following last dose of cisplatin; this inclusion is necessary because the treatment in this study may be significantly teratogenic. - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information
Exclusion Criteria
- Patients with oral cavity cancer, nasopharynx cancer, or p16-negative cancer of unknown primary (CUP) - Recurrence of the study cancer - Definitive clinical or radiologic evidence of distant metastatic disease - Prior systemic chemotherapy for the study cancer; note that prior chemotherapy for a different cancer is allowable, however, any prior exposure to cisplatin is excluded - Prior radiotherapy to the region of the study cancer that would result in overlap of radiation therapy fields - Severe, active co-morbidity defined as follows: - Unstable angina requiring hospitalization in the last 6 months - Myocardial infarction within the last 6 months - New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification.) - Persistent grade 3-4 (CTCAE version 5.0) electrolyte abnormalities that cannot be reversed despite replacement as indicated by repeat testing - Patient must not have an active infection requiring IV antibiotics prior to registration; - Other chronic renal disease like nephrotic syndrome, that could be worsened by cisplatin therapy - History of allogenic organ transplantation - Any symptomatic peripheral sensory neuropathy grade >= 2 (CTCAE version 5.0); - Pregnancy and individuals unwilling to discontinue nursing - History of hypersensitivity to cisplatin or platinum-containing compounds
Study Design
- Phase
- Phase 2/Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator ARM I (radiation therapy, every 3 week cisplatin) |
Patients undergo radiation therapy over 5 fractions a week for a total of 33-35 fractions in the absence of disease progression or unacceptable toxicity. Patients also receive cisplatin IV once Q3W (on days 1, 22, and 43) during radiation therapy in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, or MRI or PET scan throughout the study. |
|
|
Experimental Arm II (radiation therapy, weekly cisplatin) |
Patients undergo radiation therapy over 5 fractions a week for a total of 33-35 fractions in the absence of disease progression or unacceptable toxicity. Patients also receive weekly cisplatin IV QW for 7 weeks during radiation therapy in the absence of disease progression or unacceptable toxicity. Patients undergo CT scan, or MRI or PET scan throughout the study. |
|
Recruiting Locations
Mobile Infirmary Medical Center
Mobile 4076598, Alabama 4829764 36607
Mobile 4076598, Alabama 4829764 36607
Contact:
Site Public Contact
251-435-3942
Site Public Contact
251-435-3942
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Jonesboro 4116834, Arkansas 4099753 72401
University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Kaiser Permanente-Anaheim
Anaheim 5323810, California 5332921 92806
Anaheim 5323810, California 5332921 92806
Kaiser Permanente-Deer Valley Medical Center
Antioch 5324200, California 5332921 94531
Antioch 5324200, California 5332921 94531
Sutter Auburn Faith Hospital
Auburn 5325223, California 5332921 95602
Auburn 5325223, California 5332921 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn 5325223, California 5332921 95603
Auburn 5325223, California 5332921 95603
Kaiser Permanente-Bellflower
Bellflower 5327422, California 5332921 90706
Bellflower 5327422, California 5332921 90706
Alta Bates Summit Medical Center-Herrick Campus
Berkeley 5327684, California 5332921 94704
Berkeley 5327684, California 5332921 94704
Tower Cancer Research Foundation
Beverly Hills 5328041, California 5332921 90211
Beverly Hills 5328041, California 5332921 90211
Mercy Cancer Center - Carmichael
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
UC Irvine Health Cancer Center-Newport
Costa Mesa 5339840, California 5332921 92627
Costa Mesa 5339840, California 5332921 92627
Contact:
Site Public Contact
877-827-8839
Site Public Contact
877-827-8839
Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Elk Grove 5346111, California 5332921 95758
UC San Diego Health System - Encinitas
Encinitas 5346646, California 5332921 92024
Encinitas 5346646, California 5332921 92024
Contact:
Site Public Contact
760-536-7700
Site Public Contact
760-536-7700
Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Palo Alto Medical Foundation-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Fresno Cancer Center
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
Kaiser Permanente-Fresno
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921 92612
Irvine 5359777, California 5332921 92612
Kaiser Permanente-Irvine
Irvine 5359777, California 5332921 92618
Irvine 5359777, California 5332921 92618
UC San Diego Moores Cancer Center
La Jolla 5363943, California 5332921 92093
La Jolla 5363943, California 5332921 92093
The Angeles Clinic and Research Institute - West Los Angeles Office
Los Angeles 5368361, California 5332921 90025
Los Angeles 5368361, California 5332921 90025
Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921 90027
Los Angeles 5368361, California 5332921 90027
Cedars Sinai Medical Center
Los Angeles 5368361, California 5332921 90048
Los Angeles 5368361, California 5332921 90048
Contact:
Site Public Contact
310-423-8965
Site Public Contact
310-423-8965
Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Memorial Medical Center
Modesto 5373900, California 5332921 95355
Modesto 5373900, California 5332921 95355
Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Modesto 5373900, California 5332921 95356
Palo Alto Medical Foundation-Camino Division
Mountain View 5375480, California 5332921 94040
Mountain View 5375480, California 5332921 94040
Kaiser Permanente Oakland-Broadway
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Kaiser Permanente-Ontario
Ontario 5379439, California 5332921 91761
Ontario 5379439, California 5332921 91761
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921 92868
Orange 5379513, California 5332921 92868
Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Palo Alto 5380748, California 5332921 94301
Stanford Cancer Institute Palo Alto
Palo Alto 5380748, California 5332921 94304
Palo Alto 5380748, California 5332921 94304
VA Palo Alto Health Care System
Palo Alto 5380748, California 5332921 94304
Palo Alto 5380748, California 5332921 94304
Contact:
Site Public Contact
800-455-0057
Site Public Contact
800-455-0057
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova 5385941, California 5332921 95670
Rancho Cordova 5385941, California 5332921 95670
Kaiser Permanente- Marshall Medical Offices
Redwood City 5386834, California 5332921 94063
Redwood City 5386834, California 5332921 94063
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Kaiser Permanente-Richmond
Richmond 5387428, California 5332921 94801
Richmond 5387428, California 5332921 94801
Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Rocklin 5388319, California 5332921 95765
Rohnert Park Cancer Center
Rohnert Park 5388564, California 5332921 94928
Rohnert Park 5388564, California 5332921 94928
Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sutter Roseville Medical Center
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville 5388881, California 5332921 95678
Roseville 5388881, California 5332921 95678
Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Sacramento 5389489, California 5332921 95814
Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089
Site Public Contact
916-734-3089
Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
South Sacramento Cancer Center
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
UC San Diego Medical Center - Hillcrest
San Diego 5391811, California 5332921 92103
San Diego 5391811, California 5332921 92103
Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
UCSF Medical Center-Mount Zion
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
Contact:
Site Public Contact
877-827-3222
Site Public Contact
877-827-3222
UCSF Medical Center-Mission Bay
San Francisco 5391959, California 5332921 94158
San Francisco 5391959, California 5332921 94158
Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
San Jose 5392171, California 5332921 95119
Stanford Cancer Center South Bay
San Jose 5392171, California 5332921 95124
San Jose 5392171, California 5332921 95124
Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
San Leandro 5392263, California 5332921 94577
Kaiser San Rafael-Gallinas
San Rafael 5392567, California 5332921 94903
San Rafael 5392567, California 5332921 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Santa Clara 5393015, California 5332921 95051
Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Kaiser Permanente Cancer Treatment Center
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Kaiser Permanente-Stockton
Stockton 5399020, California 5332921 95210
Stockton 5399020, California 5332921 95210
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Sunnyvale 5400075, California 5332921 94086
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee 5403676, California 5332921 96161
Truckee 5403676, California 5332921 96161
Contact:
Site Public Contact
530-582-6450
Site Public Contact
530-582-6450
Kaiser Permanente Medical Center-Vacaville
Vacaville 5405228, California 5332921 95688
Vacaville 5405228, California 5332921 95688
Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Vallejo 5405380, California 5332921 94589
Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Walnut Creek 5406990, California 5332921 94596
Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Woodland 5410430, California 5332921 95695
Saint Francis Cancer Center
Colorado Springs 5417598, Colorado 5417618 80923
Colorado Springs 5417598, Colorado 5417618 80923
Kaiser Permanente-Franklin
Denver 5419384, Colorado 5417618 80205
Denver 5419384, Colorado 5417618 80205
Saint Joseph Hospital - Cancer Centers of Colorado
Denver 5419384, Colorado 5417618 80218
Denver 5419384, Colorado 5417618 80218
Contact:
Site Public Contact
303-318-3413
Site Public Contact
303-318-3413
Lutheran Hospital - Cancer Centers of Colorado
Golden 5423294, Colorado 5417618 80401
Golden 5423294, Colorado 5417618 80401
Kaiser Permanente-Rock Creek
Lafayette 5427771, Colorado 5417618 80026
Lafayette 5427771, Colorado 5417618 80026
Kaiser Permanente-Lone Tree
Lone Tree 5429208, Colorado 5417618 80124
Lone Tree 5429208, Colorado 5417618 80124
MedStar Georgetown University Hospital
Washington D.C. 4140963, District of Columbia 4138106 20007
Washington D.C. 4140963, District of Columbia 4138106 20007
Contact:
Site Public Contact
202-444-2223
Site Public Contact
202-444-2223
George Washington University Medical Center
Washington D.C. 4140963, District of Columbia 4138106 20037
Washington D.C. 4140963, District of Columbia 4138106 20037
Contact:
Site Public Contact
202-741-2210
Site Public Contact
202-741-2210
UM Sylvester Comprehensive Cancer Center at Aventura
Aventura 4146429, Florida 4155751 33180
Aventura 4146429, Florida 4155751 33180
Contact:
Site Public Contact
954-461-2180
Site Public Contact
954-461-2180
Bay Pines VA Healthcare System
Bay Pines 4146855, Florida 4155751 33744
Bay Pines 4146855, Florida 4155751 33744
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables 4151871, Florida 4155751 33146
Coral Gables 4151871, Florida 4155751 33146
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach 4153071, Florida 4155751 33442
Deerfield Beach 4153071, Florida 4155751 33442
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami 4164138, Florida 4155751 33136
Miami 4164138, Florida 4155751 33136
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Kendall
Miami 4164138, Florida 4155751 33176
Miami 4164138, Florida 4155751 33176
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Plantation
Plantation 4168782, Florida 4155751 33324
Plantation 4168782, Florida 4155751 33324
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
Moffitt Cancer Center-International Plaza
Tampa 4174757, Florida 4155751 33607
Tampa 4174757, Florida 4155751 33607
Moffitt Cancer Center - McKinley Campus
Tampa 4174757, Florida 4155751 33612
Tampa 4174757, Florida 4155751 33612
Moffitt Cancer Center
Tampa 4174757, Florida 4155751 33612
Tampa 4174757, Florida 4155751 33612
Moffitt Cancer Center at Wesley Chapel
Wesley Chapel 4177727, Florida 4155751 33544
Wesley Chapel 4177727, Florida 4155751 33544
Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Augusta 4180531, Georgia 4197000 30912
Rush - Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Aurora 4883817, Illinois 4896861 60504
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
John H Stroger Jr Hospital of Cook County
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-864-5204
Site Public Contact
312-864-5204
Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Danville 4889426, Illinois 4896861 61832
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Edward Hines Jr VA Hospital
Hines 4896005, Illinois 4896861 60141
Hines 4896005, Illinois 4896861 60141
Contact:
Site Public Contact
708-202-8387
Site Public Contact
708-202-8387
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Mattoon 4244099, Illinois 4896861 61938
Loyola University Medical Center
Maywood 4901514, Illinois 4896861 60153
Maywood 4901514, Illinois 4896861 60153
Contact:
Site Public Contact
708-226-4357
Site Public Contact
708-226-4357
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Peoria 4905687, Illinois 4896861 61636
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861 61114
Rockford 4907959, Illinois 4896861 61114
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Greater Regional Medical Center
Creston 4853078, Iowa 4862182 50801
Creston 4853078, Iowa 4862182 50801
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727
Site Public Contact
515-241-6727
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-282-2200
Site Public Contact
515-282-2200
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Iowa Lutheran Hospital
Des Moines 4853828, Iowa 4862182 50316
Des Moines 4853828, Iowa 4862182 50316
Contact:
Site Public Contact
515-241-8704
Site Public Contact
515-241-8704
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Methodist West Hospital
West Des Moines 4881346, Iowa 4862182 50266-7700
West Des Moines 4881346, Iowa 4862182 50266-7700
Contact:
Site Public Contact
515-343-1000
Site Public Contact
515-343-1000
Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182 50266
West Des Moines 4881346, Iowa 4862182 50266
University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Kansas City 4273837, Kansas 4273857 66160
The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Olathe 4276614, Kansas 4273857 66061
University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Overland Park 4276873, Kansas 4273857 66210
Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Salina 4278890, Kansas 4273857 67401
University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Westwood 4281639, Kansas 4273857 66205
Saint Joseph Hospital
Lexington 4297983, Kentucky 6254925 40504
Lexington 4297983, Kentucky 6254925 40504
Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925 40504
Lexington 4297983, Kentucky 6254925 40504
Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925 40509
Lexington 4297983, Kentucky 6254925 40509
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379
Site Public Contact
859-257-3379
The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925 40202
Louisville 4299276, Kentucky 6254925 40202
Contact:
Site Public Contact
502-562-3429
Site Public Contact
502-562-3429
UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925 40245
Louisville 4299276, Kentucky 6254925 40245
Louisiana State University Health Science Center
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
MaineHealth Coastal Cancer Treatment Center
Bath 4957570, Maine 4971068 04530
Bath 4957570, Maine 4971068 04530
MaineHealth Maine Medical Center - Biddeford
Biddeford 4958141, Maine 4971068 04005
Biddeford 4958141, Maine 4971068 04005
Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
Brewer 4959233, Maine 4971068 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Portland 4975802, Maine 4971068 04102
MaineHealth Cancer Care and IV Therapy - Sanford
Sanford 4977762, Maine 4971068 04073
Sanford 4977762, Maine 4971068 04073
MaineHealth Cancer Care Center of York County
Sanford 4977762, Maine 4971068 04073
Sanford 4977762, Maine 4971068 04073
Contact:
Site Public Contact
207-459-1600
Site Public Contact
207-459-1600
MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Scarborough 4977882, Maine 4971068 04074
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
South Portland 4979244, Maine 4971068 04106
Maryland Proton Treatment Center
Baltimore 4347778, Maryland 4361885 21201
Baltimore 4347778, Maryland 4361885 21201
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823
Site Public Contact
800-888-8823
UM Upper Chesapeake Medical Center
Bel Air 4348240, Maryland 4361885 21014
Bel Air 4348240, Maryland 4361885 21014
Contact:
Site Public Contact
443-643-3010
Site Public Contact
443-643-3010
Central Maryland Radiation Oncology in Howard County
Columbia 4352053, Maryland 4361885 21044
Columbia 4352053, Maryland 4361885 21044
Contact:
Site Public Contact
443-546-1300
Site Public Contact
443-546-1300
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885 21061
Glen Burnie 4356188, Maryland 4361885 21061
Contact:
Site Public Contact
410-553-8100
Site Public Contact
410-553-8100
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Ann Arbor 4984247, Michigan 5001836 48106
University of Michigan Comprehensive Cancer Center
Ann Arbor 4984247, Michigan 5001836 48109
Ann Arbor 4984247, Michigan 5001836 48109
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
University of Michigan - Brighton Center for Specialty Care
Brighton 4986994, Michigan 5001836 48116
Brighton 4986994, Michigan 5001836 48116
Contact:
Site Public Contact
800-865-1125
Site Public Contact
800-865-1125
Henry Ford Cancer Institute-Downriver
Brownstown, Michigan 5001836 48183
Brownstown, Michigan 5001836 48183
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Trinity Health Medical Center - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Henry Ford Macomb Hospital-Clinton Township
Clinton Township 4989133, Michigan 5001836 48038
Clinton Township 4989133, Michigan 5001836 48038
Henry Ford Medical Center-Fairlane
Dearborn 4990510, Michigan 5001836 48126
Dearborn 4990510, Michigan 5001836 48126
Henry Ford Hospital
Detroit 4990729, Michigan 5001836 48202
Detroit 4990729, Michigan 5001836 48202
Henry Ford Health Saint John Hospital
Detroit 4990729, Michigan 5001836 48236
Detroit 4990729, Michigan 5001836 48236
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Hurley Medical Center
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Allegiance Health
Jackson 4997384, Michigan 5001836 49201
Jackson 4997384, Michigan 5001836 49201
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Livonia 4999837, Michigan 5001836 48154
Henry Ford Health Providence Novi Hospital
Novi 5004062, Michigan 5001836 48374
Novi 5004062, Michigan 5001836 48374
Henry Ford Medical Center-Columbus
Novi 5004062, Michigan 5001836 48377
Novi 5004062, Michigan 5001836 48377
Michigan Healthcare Professionals Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Henry Ford Health Providence Southfield Hospital
Southfield 5010636, Michigan 5001836 48075
Southfield 5010636, Michigan 5001836 48075
Henry Ford Health Warren Hospital
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
Henry Ford West Bloomfield Hospital
West Bloomfield 7259621, Michigan 5001836 48322
West Bloomfield 7259621, Michigan 5001836 48322
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Ypsilanti 5015688, Michigan 5001836 48197
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud 5044407, Minnesota 5037779 56303
Saint Cloud 5044407, Minnesota 5037779 56303
Baptist Memorial Hospital and Cancer Center-Golden Triangle
Columbus 4422442, Mississippi 4436296 39705
Columbus 4422442, Mississippi 4436296 39705
Baptist Cancer Center-Grenada
Grenada 4428539, Mississippi 4436296 38901
Grenada 4428539, Mississippi 4436296 38901
Gulfport Memorial Hospital
Gulfport 4428667, Mississippi 4436296 39502
Gulfport 4428667, Mississippi 4436296 39502
University of Mississippi Medical Center
Jackson 4431410, Mississippi 4436296 39216
Jackson 4431410, Mississippi 4436296 39216
Contact:
Site Public Contact
601-815-6700
Site Public Contact
601-815-6700
Baptist Memorial Hospital and Cancer Center-Union County
New Albany 4438121, Mississippi 4436296 38652
New Albany 4438121, Mississippi 4436296 38652
Baptist Memorial Hospital and Cancer Center-Oxford
Oxford 4440076, Mississippi 4436296 38655
Oxford 4440076, Mississippi 4436296 38655
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Southhaven 4446702, Mississippi 4436296 38671
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Joplin 4392768, Missouri 4398678 64804
University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Kansas City 4393217, Missouri 4398678 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Lee's Summit 4394870, Missouri 4398678 64064
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City 4400860, Missouri 4398678 64116
North Kansas City 4400860, Missouri 4398678 64116
Mercy Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-6379
Site Public Contact
573-458-6379
Phelps Health Delbert Day Cancer Institute
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield 4409896, Missouri 4398678 65807
Springfield 4409896, Missouri 4398678 65807
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Bozeman 5641727, Montana 5667009 59715
Saint James Community Hospital and Cancer Treatment Center
Butte 5642934, Montana 5667009 59701
Butte 5642934, Montana 5667009 59701
Contact:
Site Public Contact
406-723-2621
Site Public Contact
406-723-2621
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Great Falls 5655240, Montana 5667009 59405
Hi-Line Sletten Cancer Center
Havre 5656497, Montana 5667009 59501
Havre 5656497, Montana 5667009 59501
Nebraska Medicine-Bellevue
Bellevue 5063805, Nebraska 5073708 68123
Bellevue 5063805, Nebraska 5073708 68123
Nebraska Medicine-Village Pointe
Omaha 5074472, Nebraska 5073708 68118
Omaha 5074472, Nebraska 5073708 68118
Contact:
Site Public Contact
402-559-5600
Site Public Contact
402-559-5600
University of Nebraska Medical Center
Omaha 5074472, Nebraska 5073708 68198
Omaha 5074472, Nebraska 5073708 68198
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Lebanon 5088597, New Hampshire 5090174 03756
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Albuquerque 5454711, New Mexico 5481136 87106
Roswell Park Cancer Institute
Buffalo 5110629, New York 5128638 14263
Buffalo 5110629, New York 5128638 14263
Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700
Site Public Contact
518-926-6700
Highland Hospital
Rochester 5134086, New York 5128638 14620
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113
Site Public Contact
585-341-8113
University of Rochester
Rochester 5134086, New York 5128638 14642
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Webster 5143495, New York 5128638 14580
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst 4485272, North Carolina 4482348 28374
Pinehurst 4485272, North Carolina 4482348 28374
Novant Cancer Institute Radiation Oncology - Supply
Supply 4830472, North Carolina 4482348 28462
Supply 4830472, North Carolina 4482348 28462
Contact:
Site Public Contact
910-754-4716
Site Public Contact
910-754-4716
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro 4499138, North Carolina 4482348 28659
Wilkesboro 4499138, North Carolina 4482348 28659
Contact:
Site Public Contact
888-716-9253
Site Public Contact
888-716-9253
Novant Health Cancer Institute Radiation Oncology - Wilmington
Wilmington 4499379, North Carolina 4482348 28401
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-251-1839
Site Public Contact
910-251-1839
Novant Health New Hanover Regional Medical Center
Wilmington 4499379, North Carolina 4482348 28401
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-342-3000
Site Public Contact
910-342-3000
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348 27157
Winston-Salem 4499612, North Carolina 4482348 27157
Contact:
Site Public Contact
336-713-6771
Site Public Contact
336-713-6771
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Summa Health System - Akron Campus
Akron 5145476, Ohio 5165418 44304
Akron 5145476, Ohio 5165418 44304
UH Seidman Cancer Center at UH Avon Health Center
Avon 5146277, Ohio 5165418 44011
Avon 5146277, Ohio 5165418 44011
Contact:
Site Public Contact
800-641-2422
Site Public Contact
800-641-2422
Summa Health System - Barberton Campus
Barberton 5146491, Ohio 5165418 44203
Barberton 5146491, Ohio 5165418 44203
Indu and Raj Soin Medical Center
Beavercreek 4506008, Ohio 5165418 45431
Beavercreek 4506008, Ohio 5165418 45431
Dayton Physicians LLC-Miami Valley South
Centerville 4508204, Ohio 5165418 45459
Centerville 4508204, Ohio 5165418 45459
Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Centerville 4508204, Ohio 5165418 45459
Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Cleveland 5150529, Ohio 5165418 44106
MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418 44109
Cleveland 5150529, Ohio 5165418 44109
Cleveland Clinic Cancer Center/Fairview Hospital
Cleveland 5150529, Ohio 5165418 44111
Cleveland 5150529, Ohio 5165418 44111
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418 44195
Cleveland 5150529, Ohio 5165418 44195
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43210
Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320
Site Public Contact
937-276-8320
Dayton Physician LLC - Englewood
Dayton 4509884, Ohio 5165418 45415
Dayton 4509884, Ohio 5165418 45415
Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Dayton 4509884, Ohio 5165418 45415
Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Franklin 4512203, Ohio 5165418 45005-1066
Dayton Physicians LLC-Atrium
Franklin 4512203, Ohio 5165418 45005
Franklin 4512203, Ohio 5165418 45005
Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515
Site Public Contact
937-569-7515
Kettering Medical Center
Kettering 4515843, Ohio 5165418 45429
Kettering 4515843, Ohio 5165418 45429
Cleveland Clinic Cancer Center Mansfield
Mansfield 5161723, Ohio 5165418 44906
Mansfield 5161723, Ohio 5165418 44906
Hillcrest Hospital Cancer Center
Mayfield Heights 5162188, Ohio 5165418 44124
Mayfield Heights 5162188, Ohio 5165418 44124
Summa Health Medina Medical Center
Medina 5162512, Ohio 5165418 44256
Medina 5162512, Ohio 5165418 44256
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor 5162645, Ohio 5165418 44060
Mentor 5162645, Ohio 5165418 44060
University Hospitals Portage Medical Center
Ravenna 5167737, Ohio 5165418 44266
Ravenna 5167737, Ohio 5165418 44266
North Coast Cancer Care
Sandusky 5170691, Ohio 5165418 44870
Sandusky 5170691, Ohio 5165418 44870
Cleveland Clinic Cancer Center Strongsville
Strongsville 5173237, Ohio 5165418 44136
Strongsville 5173237, Ohio 5165418 44136
ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
Sylvania 5173572, Ohio 5165418 43560
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418 43606
Toledo 5174035, Ohio 5165418 43606
Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Troy 5174358, Ohio 5165418 45373
Cleveland Clinic Wooster Family Health and Surgery Center
Wooster 5177358, Ohio 5165418 44691
Wooster 5177358, Ohio 5165418 44691
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73104
Bryn Mawr Hospital
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Bryn Mawr 5182063, Pennsylvania 6254927 19010
Saint Vincent Hospital
Erie 5188843, Pennsylvania 6254927 16544
Erie 5188843, Pennsylvania 6254927 16544
Contact:
Site Public Contact
814-452-5000
Site Public Contact
814-452-5000
Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Hershey 5193342, Pennsylvania 6254927 17033-0850
Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Riddle Memorial Hospital
Media 4559575, Pennsylvania 6254927 19063
Media 4559575, Pennsylvania 6254927 19063
Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-858-7746
Site Public Contact
412-858-7746
Paoli Memorial Hospital
Paoli 5205037, Pennsylvania 6254927 19301
Paoli 5205037, Pennsylvania 6254927 19301
Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19111
Philadelphia 4560349, Pennsylvania 6254927 19111
Contact:
Site Public Contact
215-728-4790
Site Public Contact
215-728-4790
Temple University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19140
Philadelphia 4560349, Pennsylvania 6254927 19140
Contact:
Site Public Contact
215-728-2983
Site Public Contact
215-728-2983
Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000
Site Public Contact
877-284-2000
Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
Wexford 5219062, Pennsylvania 6254927 15090
Lankenau Medical Center
Wynnewood 5220230, Pennsylvania 6254927 19096
Wynnewood 5220230, Pennsylvania 6254927 19096
Medical University of South Carolina
Charleston 4574324, South Carolina 4597040 29425
Charleston 4574324, South Carolina 4597040 29425
Self Regional Healthcare
Greenwood 4580569, South Carolina 4597040 29646
Greenwood 4580569, South Carolina 4597040 29646
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Collierville 4614748, Tennessee 4662168 38017
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Memphis 4641239, Tennessee 4662168 38120
Houston Methodist San Jacinto Hospital
Baytown 4672731, Texas 4736286 77521
Baytown 4672731, Texas 4736286 77521
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Ben Taub General Hospital
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-873-2000
Site Public Contact
713-873-2000
Houston Methodist Hospital
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-790-2700
Site Public Contact
713-790-2700
Methodist Willowbrook Hospital
Houston 4699066, Texas 4736286 77070
Houston 4699066, Texas 4736286 77070
Houston Methodist West Hospital
Houston 4699066, Texas 4736286 77094
Houston 4699066, Texas 4736286 77094
Contact:
Site Public Contact
832-522-2873
Site Public Contact
832-522-2873
Houston Methodist Saint John Hospital
Nassau Bay 4713813, Texas 4736286 77058
Nassau Bay 4713813, Texas 4736286 77058
Houston Methodist Sugar Land Hospital
Sugar Land 4734825, Texas 4736286 77479
Sugar Land 4734825, Texas 4736286 77479
Contact:
Site Public Contact
281-242-2873
Site Public Contact
281-242-2873
Houston Methodist The Woodlands Hospital
The Woodlands 4736476, Texas 4736286 77385
The Woodlands 4736476, Texas 4736286 77385
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork 5844096, Utah 5549030 84003
American Fork 5844096, Utah 5549030 84003
Sandra L Maxwell Cancer Center
Cedar City 5536630, Utah 5549030 84720
Cedar City 5536630, Utah 5549030 84720
Logan Regional Hospital
Logan 5777544, Utah 5549030 84321
Logan 5777544, Utah 5549030 84321
Intermountain Medical Center
Murray 5778755, Utah 5549030 84107
Murray 5778755, Utah 5549030 84107
McKay-Dee Hospital Center
Ogden 5779206, Utah 5549030 84403
Ogden 5779206, Utah 5549030 84403
Utah Valley Regional Medical Center
Provo 5780026, Utah 5549030 84604
Provo 5780026, Utah 5549030 84604
Riverton Hospital
Riverton 5780557, Utah 5549030 84065
Riverton 5780557, Utah 5549030 84065
Utah Cancer Specialists-Salt Lake City
Salt Lake City 5780993, Utah 5549030 84106
Salt Lake City 5780993, Utah 5549030 84106
Huntsman Cancer Institute/University of Utah
Salt Lake City 5780993, Utah 5549030 84112
Salt Lake City 5780993, Utah 5549030 84112
LDS Hospital
Salt Lake City 5780993, Utah 5549030 84143
Salt Lake City 5780993, Utah 5549030 84143
Saint George Regional Medical Center
St. George 5546220, Utah 5549030 84770
St. George 5546220, Utah 5549030 84770
Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Saint Johnsbury 5240656, Vermont 5242283 05819
Inova Alexandria Hospital
Alexandria 4744091, Virginia 6254928 22304
Alexandria 4744091, Virginia 6254928 22304
Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Fairfax 4758023, Virginia 6254928 22031
Inova Fair Oaks Hospital
Fairfax 4758023, Virginia 6254928 22033
Fairfax 4758023, Virginia 6254928 22033
FHCC Overlake
Bellevue 5786882, Washington 5815135 98004
Bellevue 5786882, Washington 5815135 98004
Contact:
Site Public Contact
425-454-2148
Site Public Contact
425-454-2148
FHCC at EvergreenHealth
Kirkland 5799841, Washington 5815135 98034
Kirkland 5799841, Washington 5815135 98034
Contact:
Site Public Contact
425-899-6000
Site Public Contact
425-899-6000
Fred Hutchinson Cancer Center
Seattle 5809844, Washington 5815135 98109
Seattle 5809844, Washington 5815135 98109
Contact:
Site Public Contact
800-804-8824
Site Public Contact
800-804-8824
FHCC at Northwest Hospital
Seattle 5809844, Washington 5815135 98133
Seattle 5809844, Washington 5815135 98133
Contact:
Site Public Contact
206-606-5800
Site Public Contact
206-606-5800
University of Washington Medical Center - Montlake
Seattle 5809844, Washington 5815135 98195
Seattle 5809844, Washington 5815135 98195
Contact:
Site Public Contact
800-804-8824
Site Public Contact
800-804-8824
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850 25304
Charleston 4801859, West Virginia 4826850 25304
Contact:
Site Public Contact
304-388-9944
Site Public Contact
304-388-9944
Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Antigo 5244010, Wisconsin 5279468 54409
Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Eau Claire 5251436, Wisconsin 5279468 54701
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
Johnson Creek 5257996, Wisconsin 5279468 53038
Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468 54601
La Crosse 5258957, Wisconsin 5279468 54601
William S Middleton VA Medical Center
Madison 5261457, Wisconsin 5279468 53705
Madison 5261457, Wisconsin 5279468 53705
Contact:
Site Public Contact
608-256-1901
Site Public Contact
608-256-1901
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Madison 5261457, Wisconsin 5279468 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Madison 5261457, Wisconsin 5279468 53792
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Marshfield 5261969, Wisconsin 5279468 54449
Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100
Site Public Contact
262-257-5100
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666
Site Public Contact
414-805-3666
Zablocki Veterans Administration Medical Center
Milwaukee 5263045, Wisconsin 5279468 53295
Milwaukee 5263045, Wisconsin 5279468 53295
Contact:
Site Public Contact
888-469-6614
Site Public Contact
888-469-6614
Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Minocqua 5263156, Wisconsin 5279468 54548
ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Mukwonago 5263965, Wisconsin 5279468 53149
Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
Rhinelander 5268720, Wisconsin 5279468 54501
Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Rice Lake 5268798, Wisconsin 5279468 54868
Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
Stevens Point 5274644, Wisconsin 5279468 54481
Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Stevens Point 5274644, Wisconsin 5279468 54482
UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Waukesha 5278052, Wisconsin 5279468 53188
Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Weston 5278693, Wisconsin 5279468 54476
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
More Details
- NCT ID
- NCT05050162
- Status
- Recruiting
- Sponsor
- NRG Oncology
Detailed Description
PRIMARY OBJECTIVES: I. To determine whether radiation with cisplatin weekly is superior in terms of acute toxicity, as measured by the T-scores (TAME method), to radiation with cisplatin every 3 weeks for patients with locoregionally advanced squamous cell carcinoma of the head and neck (SCCHN). (Phase II) II. To determine whether radiation with cisplatin weekly is non-inferior to radiation with cisplatin every 3 weeks in terms of overall survival (OS) for patients with locoregionally advanced SCCHN. (Phase III) III. To determine whether radiation with cisplatin weekly is superior in terms of acute toxicity, as measured by the T-scores (TAME method), to radiation with cisplatin every 3 weeks for patients with locoregionally advanced SCCHN. (Phase III) SECONDARY OBJECTIVES: I. To assess and compare progression-free survival (PFS) between arms. II. To assess and compare locoregional failure and distant metastasis between arms. III. To assess acute and late toxicity (Common Terminology Criteria for Adverse Events [CTCAE] version 5.0). IV. To assess patient-reported outcomes quality of life (PRO/QOL), as measured by the Functional Assessment of Cancer Therapy-Head and Neck (FACT-H&N) (primary PRO), between arms. V. To assess hearing loss, as measured by audiograms and the modified TUNE grading scale between arms. VI. To assess hearing loss, as measured by speech audiometry Consonant-Nucleus-Consonant word scores and tympanometry (subject to the modified TUNE grading scale testing results; otherwise, it will be an exploratory objective). VII. To assess hearing-related QOL as measured by the Hearing Handicap Inventory-Screening (HHIA-S) (secondary PRO), between arms. VIII. To assess long-term PFS, OS, and toxicity between arms. IX. To assess 3-year restricted-mean survival time for OS and PFS between arms (if long-term update is warranted). EXPLORATORY OBJECTIVE: I. To collect blood and tissue specimens for future translational science studies. For instance, to examine how germline and somatic genetic variants, such as TP53, CDKN2A, PIK3CA, PTEN, NFE2L2, and KEAP1, may influence cisplatin-related efficacy and toxicity, and to assess the effect of regular nonsteroidal anti-inflammatory drugs (NSAIDs) use and genomic activation of PIK3CA (mutation or amplification) or loss of PTEN, the negative regulator of PI3K, on disease-free survival or overall survival. OUTLINE: Patients are assigned to 1 of 2 arms. ARM I (NON-OROPHARYNGEAL CANCER [OPC]/p16-NEGATIVE OPC group and p16-NEGATIVE OPC/CANCER OF UNKNOWN PRIMARY [CUP] group): Patients undergo radiation therapy over 5 fractions a week for a total of 33-35 fractions in the absence of disease progression or unacceptable toxicity. Patients also receive cisplatin intravenously (IV) once every 3 weeks (Q3W) (on days 1, 22, and 43) during radiation therapy in the absence of disease progression or unacceptable toxicity. ARM II (NON-OROPHARYNGEAL CANCER [OPC]/p16-NEGATIVE OPC group and p16-NEGATIVE OPC/CANCER OF UNKNOWN PRIMARY [CUP] group): Patients undergo radiation therapy over 5 fractions a week for a total of 33-35 fractions in the absence of disease progression or unacceptable toxicity. Patients also receive cisplatin IV once a week (QW) for 7 weeks during radiation therapy in the absence of disease progression or unacceptable toxicity. Patients undergo computed tomography (CT) scan, or magnetic resonance imaging (MRI) or position emission tomography (PET) scan throughout the study.