Testing the Addition of the Chemotherapy Drug Lomustine (Gleostine) to the Usual Treatment (Temozolomide and Radiation Therapy) for Newly Diagnosed MGMT Methylated Glioblastoma
Purpose
This phase III trial compares the effect of adding lomustine to standard chemotherapy with temozolomide and radiation therapy versus temozolomide and radiation therapy alone in shrinking or stabilizing newly diagnosed MGMT methylated glioblastoma. MGMT methylated tumors are more likely to respond to temozolomide chemotherapy. Temozolomide is in a class of medications called alkylating agents. It works by damaging the cell's DNA and may kill tumor cells and slow down or stop tumor growth. Lomustine is a chemotherapy drug and in a class of medications called alkylating agents. It damages the cell's DNA and may kill tumor cells. Radiation therapy uses high energy x-ray photons to kill tumor cells and shrink tumors. Adding lomustine to standard chemotherapy with temozolomide and radiation therapy may shrink or stabilize glioblastoma.
Conditions
- Glioblastoma
- Gliosarcoma
Eligibility
- Eligible Ages
- Between 18 Years and 70 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- STEP 1 REGISTRATION: No known IDH mutation. (If tested before step 1 registration, patients known to have IDH mutation in the tumor on local or other testing are ineligible and should not be registered) - STEP 1 REGISTRATION: Availability of formalin-fixed paraffin-embedded (FFPE) tumor tissue block and hematoxylin and eosin (H&E) stained slide to be sent for central pathology review for confirmation of histology and MGMT promoter methylation status. Note that tissue for central pathology review and central MGMT assessment must be received by the New York University (NYU) Center for Biospecimen Research and Development (CBRD) on or before postoperative calendar day 30. If tissue cannot be received by postoperative calendar day 30, then patients may NOT enroll on this trial as central pathology review will not be complete in time for the patient to start treatment no later than 8 weeks following surgery. Results of central pathology review and central MGMT analysis will generally be completed within 10 business days of receipt of tissue. Results will be entered by the central lab directly into Rave. Note: In the event of an additional tumor resection(s), tissue must be received within 30 days of the most recent resection and the latest resection must have been performed within 30 days after the initial resection. Surgical resection is required; stereotactic biopsy alone is not allowed because it will not provide sufficient tissue for MGMT analysis - STEP 1 REGISTRATION: Willing to use highly effective method of contraception for participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) during therapy and for 6 months after completing treatment; this inclusion is necessary because the treatment in this study may be significantly teratogenic - STEP 1 REGISTRATION: The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information - STEP 2 REGISTRATION: Histopathologically proven diagnosis of glioblastoma (or gliosarcoma as a subtype of glioblastoma) confirmed by central pathology review - STEP 2 REGISTRATION: MGMT promoter with methylation confirmed by central pathology review. Note: Patients with tissue that is insufficient or inadequate for analysis, fails MGMT testing, or has indeterminate or unmethylated MGMT promoter are excluded - Note: Any MGMT result other than methylated would require step 2 registration to be reported as a "central review failure" - STEP 2 REGISTRATION: Contrast-enhanced brain MRI performed either after surgery or prior to step 2 registration - STEP 2 REGISTRATION: IDH mutation testing by at least one method (such as immunohistochemistry for IDH1 R132H) must be performed as part of standard of care and no mutation must be found (i.e IDH wildtype). (If a mutation is identified then the patient will be ineligible and must be registered as ineligible at step 2.) - STEP 2 REGISTRATION: History/physical examination within 28 days prior to step 2 registration - STEP 2 REGISTRATION: Karnofsky performance status (KPS) >= 70 within 28 days prior to step 2 registration - STEP 2 REGISTRATION: Neurologic function assessment within 28 days prior to step 2 registration - STEP 2 REGISTRATION: Age 18-70 years - STEP 2 REGISTRATION: Hemoglobin >= 10 g/dl (Note: the use of transfusion or other intervention to achieve hemoglobin [Hgb] >= 10.0 g/dl is acceptable) (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Leukocytes >= 2,000/mm^3 (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Absolute neutrophil count >= 1,500/mm^3 (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Platelets >= 100,000/mm^3 (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Total bilirubin =< 1.5 x institutional/lab upper limit of normal (ULN) (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Aspartate aminotransferase (AST) (serum glutamic-oxaloacetic transaminase [SGOT]) =< 2.5 x ULN (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.5 x ULN (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: Serum creatinine =< 1.5 x ULN OR creatinine clearance (CrCl) >= 50 mL/min (if using the Cockcroft-Gault formula) (Within 14 days prior to step 2 registration) - STEP 2 REGISTRATION: For patients with evidence of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy, if indicated - Note: Known positive test for hepatitis B virus surface antigen (HBV sAg) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy. Patients who are immune to hepatitis B (anti-hepatitis B surface antibody positive) are eligible (e.g. patients immunized against hepatitis B) - STEP 2 REGISTRATION: For patients with a history of hepatitis C virus (HCV) infection must have been treated and cured. For patients with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load - Note: Known positive test for hepatitis C virus ribonucleic acid (HCV ribonucleic acid [RNA]) indicating acute or chronic infection would make the patient ineligible unless the viral load becomes undetectable on suppressive therapy - STEP 2 REGISTRATION: Known human immunodeficiency virus (HIV) infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to step 2 registration are eligible for this trial. Testing is not required for entry into protocol - STEP 2 REGISTRATION: Negative serum or urine pregnancy test (in persons of childbearing potential) within 14 days prior to step 2 registration - Childbearing potential is defined as any person who has experienced menarche and who has not undergone surgical sterilization (hysterectomy or bilateral oophorectomy) or who is not postmenopausal
Exclusion Criteria
- STEP 2 REGISTRATION: Prior therapy for tumor except for resection or prior laser interstitial thermal therapy (LITT). For example, prior chemotherapy, immunotherapy, or targeted therapy for GBM or lower grade glioma is disallowed (including but not limited to temozolomide, lomustine, bevacizumab, any viral therapy, ipilimumab or other CTLA-4 antibody, PD-1 antibody, CD-137 agonist, CD40 antibody, PDL-1 or 2 antibody, vaccine therapy, polio or similar viral injection as treatment for the tumor, and/or any other antibody or drug specifically targeting T-cell co-stimulation or immune checkpoint pathways) as is Gliadel wafer, radiotherapy, radiosurgery, vaccine or other immunotherapy, brachytherapy, or convection enhanced delivery - Note: 5-aminolevulinic acid (ALA)-mediated fluorescent guided resection (FGR) photodynamic therapy (PDT) or fluorescein administered prior to/during surgery to aid resection is not exclusionary and is not considered a chemotherapy or intracerebral agent. Prior laser interstitial thermal therapy (LITT) is allowed - STEP 2 REGISTRATION: Current or planned treatment with any other investigational agents for the study cancer - STEP 2 REGISTRATION: Definitive clinical or radiologic evidence of metastatic disease outside the brain - STEP 2 REGISTRATION: Prior invasive malignancy (except non-melanomatous skin cancer, cervical cancer in situ and melanoma in situ) unless disease free for a minimum of 2 years - STEP 2 REGISTRATION: Prior radiotherapy to the head or neck that would result in overlap of radiation therapy fields - STEP 2 REGISTRATION: Pregnancy and individuals unwilling to discontinue nursing due to the potential teratogenic effects and potential risk for adverse events in nursing infants - STEP 2 REGISTRATION: History of allergic reactions attributed to compounds of similar chemical or biologic composition to temozolomide or lomustine - STEP 2 REGISTRATION: History of pulmonary fibrosis - STEP 2 REGISTRATION: Uncontrolled intercurrent illness including, but not limited to: - Ongoing or active infection requiring intravenous (IV) antibiotics, IV antiviral, or IV antifungal treatment - Symptomatic congestive heart failure, defined as New York Heart Association Functional Classification III/IV (Note: Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification) - Unstable angina pectoris within 6 months prior to Step 2 registration - Uncontrolled cardiac arrhythmia - Psychiatric illness/social situations that would limit compliance with study requirements - STEP 2 REGISTRATION: No evidence of diffuse leptomeningeal disease that requires whole brain irradiation
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Arm I (radiation therapy, temozolomide) |
Patients undergo radiation therapy 5 days per week and receive temozolomide PO QD for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients then receive temozolomide PO QD on days 1-5 of each cycle. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI throughout the trial. |
|
|
Experimental ARM II (radiation therapy, temozolomide, lomustine) |
Patients undergo radiation therapy 5 days per week for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive lomustine PO on day 1 of each cycle and temozolomide PO QD on days 2-6 of each cycle. Treatment repeats every 42 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI throughout the trial. |
|
Recruiting Locations
Fairbanks Memorial Hospital
Fairbanks 5861897, Alaska 5879092 99701
Fairbanks 5861897, Alaska 5879092 99701
Highlands Oncology Group - Fayetteville
Fayetteville 4110486, Arkansas 4099753 72703
Fayetteville 4110486, Arkansas 4099753 72703
University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Highlands Oncology Group - Rogers
Rogers 4128894, Arkansas 4099753 72758
Rogers 4128894, Arkansas 4099753 72758
Highlands Oncology Group
Springdale 4132093, Arkansas 4099753 72762
Springdale 4132093, Arkansas 4099753 72762
Kaiser Permanente-Anaheim
Anaheim 5323810, California 5332921 92806
Anaheim 5323810, California 5332921 92806
Kaiser Permanente-Deer Valley Medical Center
Antioch 5324200, California 5332921 94531
Antioch 5324200, California 5332921 94531
Sutter Auburn Faith Hospital
Auburn 5325223, California 5332921 95602
Auburn 5325223, California 5332921 95602
Sutter Cancer Centers Radiation Oncology Services-Auburn
Auburn 5325223, California 5332921 95603
Auburn 5325223, California 5332921 95603
Kaiser Permanente-Bellflower
Bellflower 5327422, California 5332921 90706
Bellflower 5327422, California 5332921 90706
Alta Bates Summit Medical Center-Herrick Campus
Berkeley 5327684, California 5332921 94704
Berkeley 5327684, California 5332921 94704
Mercy Cancer Center - Carmichael
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
City of Hope Comprehensive Cancer Center
Duarte 5344147, California 5332921 91010
Duarte 5344147, California 5332921 91010
Kaiser Permanente Dublin
Dublin 5344157, California 5332921 94568
Dublin 5344157, California 5332921 94568
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Elk Grove 5346111, California 5332921 95758
Kaiser Permanente-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Palo Alto Medical Foundation-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Fresno Cancer Center
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
Kaiser Permanente-Fresno
Fresno 5350937, California 5332921 93720
Fresno 5350937, California 5332921 93720
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care
Irvine 5359777, California 5332921 92612
Irvine 5359777, California 5332921 92612
Kaiser Permanente Los Angeles Medical Center
Los Angeles 5368361, California 5332921 90027
Los Angeles 5368361, California 5332921 90027
Kaiser Permanente-Modesto
Modesto 5373900, California 5332921 95356
Modesto 5373900, California 5332921 95356
Palo Alto Medical Foundation-Camino Division
Mountain View 5375480, California 5332921 94040
Mountain View 5375480, California 5332921 94040
Kaiser Permanente Oakland-Broadway
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Kaiser Permanente-Oakland
Oakland 5378538, California 5332921 94611
Oakland 5378538, California 5332921 94611
Kaiser Permanente-Ontario
Ontario 5379439, California 5332921 91761
Ontario 5379439, California 5332921 91761
UC Irvine Health/Chao Family Comprehensive Cancer Center
Orange 5379513, California 5332921 92868
Orange 5379513, California 5332921 92868
Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Palo Alto 5380748, California 5332921 94301
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova 5385941, California 5332921 95670
Rancho Cordova 5385941, California 5332921 95670
Kaiser Permanente- Marshall Medical Offices
Redwood City 5386834, California 5332921 94063
Redwood City 5386834, California 5332921 94063
Contact:
Site Public Contact
877-642-4691
Site Public Contact
877-642-4691
Kaiser Permanente-Richmond
Richmond 5387428, California 5332921 94801
Richmond 5387428, California 5332921 94801
Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Rocklin 5388319, California 5332921 95765
Rohnert Park Cancer Center
Rohnert Park 5388564, California 5332921 94928
Rohnert Park 5388564, California 5332921 94928
Kaiser Permanente-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sutter Roseville Medical Center
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
The Permanente Medical Group-Roseville Radiation Oncology
Roseville 5388881, California 5332921 95678
Roseville 5388881, California 5332921 95678
Kaiser Permanente Downtown Commons
Sacramento 5389489, California 5332921 95814
Sacramento 5389489, California 5332921 95814
Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
Kaiser Permanente-South Sacramento
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
South Sacramento Cancer Center
Sacramento 5389489, California 5332921 95823
Sacramento 5389489, California 5332921 95823
Kaiser Permanente-San Diego Zion
San Diego 5391811, California 5332921 92120
San Diego 5391811, California 5332921 92120
California Pacific Medical Center-Pacific Campus
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
Kaiser Permanente-San Francisco
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
Kaiser Permanente-Santa Teresa-San Jose
San Jose 5392171, California 5332921 95119
San Jose 5392171, California 5332921 95119
Kaiser Permanente San Leandro
San Leandro 5392263, California 5332921 94577
San Leandro 5392263, California 5332921 94577
Kaiser San Rafael-Gallinas
San Rafael 5392567, California 5332921 94903
San Rafael 5392567, California 5332921 94903
Kaiser Permanente Medical Center - Santa Clara
Santa Clara 5393015, California 5332921 95051
Santa Clara 5393015, California 5332921 95051
Kaiser Permanente-Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Kaiser Permanente Cancer Treatment Center
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Kaiser Permanente-South San Francisco
South San Francisco 5397765, California 5332921 94080
South San Francisco 5397765, California 5332921 94080
Kaiser Permanente-Stockton
Stockton 5399020, California 5332921 95210
Stockton 5399020, California 5332921 95210
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Sunnyvale 5400075, California 5332921 94086
Kaiser Permanente Medical Center-Vacaville
Vacaville 5405228, California 5332921 95688
Vacaville 5405228, California 5332921 95688
Kaiser Permanente-Vallejo
Vallejo 5405380, California 5332921 94589
Vallejo 5405380, California 5332921 94589
Kaiser Permanente-Walnut Creek
Walnut Creek 5406990, California 5332921 94596
Walnut Creek 5406990, California 5332921 94596
John Muir Medical Center-Walnut Creek
Walnut Creek 5406990, California 5332921 94598
Walnut Creek 5406990, California 5332921 94598
Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Woodland 5410430, California 5332921 95695
Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80907
UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
Colorado Springs 5417598, Colorado 5417618 80909
Contact:
Site Public Contact
719-365-2406
Site Public Contact
719-365-2406
Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
Colorado Springs 5417598, Colorado 5417618 80920
Contact:
Site Public Contact
719-364-6700
Site Public Contact
719-364-6700
Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150
Site Public Contact
970-297-6150
Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Fort Collins 5577147, Colorado 5417618 80528
Lutheran Hospital - Cancer Centers of Colorado
Golden 5423294, Colorado 5417618 80401
Golden 5423294, Colorado 5417618 80401
UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Greeley 5577592, Colorado 5417618 80631
Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083
Site Public Contact
970-203-7083
Baptist MD Anderson Cancer Center
Jacksonville 4160021, Florida 4155751 32207
Jacksonville 4160021, Florida 4155751 32207
Contact:
Site Public Contact
904-202-7468
Site Public Contact
904-202-7468
Miami Cancer Institute
Miami 4164138, Florida 4155751 33176
Miami 4164138, Florida 4155751 33176
Contact:
Site Public Contact
786-596-2000
Site Public Contact
786-596-2000
Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000 30308
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
888-946-7447
Site Public Contact
888-946-7447
Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000 30322
Atlanta 4180439, Georgia 4197000 30322
Contact:
Site Public Contact
404-778-1868
Site Public Contact
404-778-1868
Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Augusta 4180531, Georgia 4197000 30912
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Boise 5586437, Idaho 5596512 83712
Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Fruitland 5593708, Idaho 5596512 83619
Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Meridian 5600685, Idaho 5596512 83642
Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83687
Nampa 5601933, Idaho 5596512 83687
Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Twin Falls 5610810, Idaho 5596512 83301
Alton Memorial Hospital
Alton 4232679, Illinois 4896861 62002
Alton 4232679, Illinois 4896861 62002
Contact:
Site Public Contact
618-463-7323
Site Public Contact
618-463-7323
Rush-Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Aurora 4883817, Illinois 4896861 60504
Advocate Outpatient Center - Aurora
Aurora 4883817, Illinois 4896861 60506
Aurora 4883817, Illinois 4896861 60506
Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847
Site Public Contact
847-842-4847
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
University of Illinois
Chicago 4887398, Illinois 4896861 60612
Chicago 4887398, Illinois 4896861 60612
Contact:
Site Public Contact
312-355-3046
Site Public Contact
312-355-3046
University of Chicago Comprehensive Cancer Center
Chicago 4887398, Illinois 4896861 60637
Chicago 4887398, Illinois 4896861 60637
Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360
Site Public Contact
773-296-5360
AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Crystal Lake 4889229, Illinois 4896861 60014
Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Danville 4889426, Illinois 4896861 61832
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Downers Grove 4890119, Illinois 4896861 60515
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907
Site Public Contact
847-429-2907
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995
Site Public Contact
708-799-9995
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Libertyville 4899739, Illinois 4896861 60048
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Mattoon 4244099, Illinois 4896861 61938
UC Comprehensive Cancer Center at Silver Cross
New Lenox 4903535, Illinois 4896861 60451
New Lenox 4903535, Illinois 4896861 60451
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622
Site Public Contact
800-323-8622
University of Chicago Medicine-Orland Park
Orland Park 4904937, Illinois 4896861 60462
Orland Park 4904937, Illinois 4896861 60462
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621
Site Public Contact
847-384-3621
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861 61637
Peoria 4905687, Illinois 4896861 61637
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
Memorial Hospital East
Shiloh 4249910, Illinois 4896861 62269
Shiloh 4249910, Illinois 4896861 62269
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
Northwest Cancer Center - Main Campus
Crown Point 4919451, Indiana 4921868 46307
Crown Point 4919451, Indiana 4921868 46307
Contact:
Site Public Contact
219-310-2550
Site Public Contact
219-310-2550
UChicago Medicine Northwest Indiana
Crown Point 4919451, Indiana 4921868 46307
Crown Point 4919451, Indiana 4921868 46307
Northwest Oncology LLC
Dyer 4919820, Indiana 4921868 46311
Dyer 4919820, Indiana 4921868 46311
Contact:
Site Public Contact
219-924-8178
Site Public Contact
219-924-8178
Northwest Cancer Center - Hobart
Hobart 4921476, Indiana 4921868 46342
Hobart 4921476, Indiana 4921868 46342
Contact:
Site Public Contact
219-947-1795
Site Public Contact
219-947-1795
Saint Mary Medical Center
Hobart 4921476, Indiana 4921868 46342
Hobart 4921476, Indiana 4921868 46342
The Community Hospital
Munster 4924014, Indiana 4921868 46321
Munster 4924014, Indiana 4921868 46321
Contact:
Site Public Contact
219-836-3349
Site Public Contact
219-836-3349
Women's Diagnostic Center - Munster
Munster 4924014, Indiana 4921868 46321
Munster 4924014, Indiana 4921868 46321
Northwest Cancer Center - Valparaiso
Valparaiso 4927537, Indiana 4921868 46383
Valparaiso 4927537, Indiana 4921868 46383
Mary Greeley Medical Center
Ames 4846834, Iowa 4862182 50010
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Ames
Ames 4846834, Iowa 4862182 50010
Ames 4846834, Iowa 4862182 50010
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Hospital
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-365-4673
Site Public Contact
319-365-4673
Oncology Associates at Mercy Medical Center
Cedar Rapids 4850751, Iowa 4862182 52403
Cedar Rapids 4850751, Iowa 4862182 52403
Contact:
Site Public Contact
319-363-2690
Site Public Contact
319-363-2690
Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Greater Regional Medical Center
Creston 4853078, Iowa 4862182 50801
Creston 4853078, Iowa 4862182 50801
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Broadlawns Medical Center
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-282-2200
Site Public Contact
515-282-2200
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Siouxland Regional Cancer Center
Sioux City 4876523, Iowa 4862182 51101
Sioux City 4876523, Iowa 4862182 51101
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182 50266
West Des Moines 4881346, Iowa 4862182 50266
University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Kansas City 4273837, Kansas 4273857 66160
University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Overland Park 4276873, Kansas 4273857 66210
University of Kansas Hospital-Indian Creek Campus
Overland Park 4276873, Kansas 4273857 66211
Overland Park 4276873, Kansas 4273857 66211
University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Westwood 4281639, Kansas 4273857 66205
Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Wichita 4281730, Kansas 4273857 67214
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379
Site Public Contact
859-257-3379
The James Graham Brown Cancer Center at University of Louisville
Louisville 4299276, Kentucky 6254925 40202
Louisville 4299276, Kentucky 6254925 40202
Contact:
Site Public Contact
502-562-3429
Site Public Contact
502-562-3429
Norton Brownsboro Hospital and Medical Campus
Louisville 4299276, Kentucky 6254925 40241
Louisville 4299276, Kentucky 6254925 40241
UofL Health Medical Center Northeast
Louisville 4299276, Kentucky 6254925 40245
Louisville 4299276, Kentucky 6254925 40245
Lafayette Family Cancer Center-EMMC
Brewer 4959233, Maine 4971068 04412
Brewer 4959233, Maine 4971068 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
University of Maryland/Greenebaum Cancer Center
Baltimore 4347778, Maryland 4361885 21201
Baltimore 4347778, Maryland 4361885 21201
Contact:
Site Public Contact
800-888-8823
Site Public Contact
800-888-8823
Central Maryland Radiation Oncology in Howard County
Columbia 4352053, Maryland 4361885 21044
Columbia 4352053, Maryland 4361885 21044
Contact:
Site Public Contact
443-546-1300
Site Public Contact
443-546-1300
UM Baltimore Washington Medical Center/Tate Cancer Center
Glen Burnie 4356188, Maryland 4361885 21061
Glen Burnie 4356188, Maryland 4361885 21061
Contact:
Site Public Contact
410-553-8100
Site Public Contact
410-553-8100
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Ann Arbor 4984247, Michigan 5001836 48106
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Trinity Health Medical Center - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Henry Ford Health Saint John Hospital
Detroit 4990729, Michigan 5001836 48236
Detroit 4990729, Michigan 5001836 48236
Corewell Health Grand Rapids Hospitals - Butterworth Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Corewell Health Grand Rapids Hospitals - Helen DeVos Children's Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Henry Ford Saint John Hospital - Van Elslander
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
Beacon Kalamazoo
Kalamazoo 4997787, Michigan 5001836 49048
Kalamazoo 4997787, Michigan 5001836 49048
Contact:
Site Public Contact
574-647-7370
Site Public Contact
574-647-7370
University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Lansing 4998830, Michigan 5001836 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Livonia 4999837, Michigan 5001836 48154
Henry Ford Saint John Hospital - Macomb Medical
Macomb 5000473, Michigan 5001836 48044
Macomb 5000473, Michigan 5001836 48044
Michigan Healthcare Professionals Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
MyMichigan Medical Center Saginaw
Saginaw 5007989, Michigan 5001836 48601
Saginaw 5007989, Michigan 5001836 48601
MyMichigan Medical Center Tawas
Tawas City 5011900, Michigan 5001836 48764
Tawas City 5011900, Michigan 5001836 48764
Henry Ford Health Warren Hospital
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Wyoming 5015618, Michigan 5001836 49519
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Ypsilanti 5015688, Michigan 5001836 48197
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Essentia Health Saint Joseph's Medical Center
Brainerd 5019116, Minnesota 5037779 56401
Brainerd 5019116, Minnesota 5037779 56401
Minnesota Oncology - Burnsville
Burnsville 5019767, Minnesota 5037779 55337
Burnsville 5019767, Minnesota 5037779 55337
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Coon Rapids 5022025, Minnesota 5037779 55433
Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779 56636
Deer River 5024099, Minnesota 5037779 56636
Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Essentia Health Saint Mary's Medical Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Edina 5025264, Minnesota 5037779 55435
Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779 55746
Hibbing 5030005, Minnesota 5037779 55746
Contact:
Site Public Contact
218-786-3308
Site Public Contact
218-786-3308
Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779 55369
Maple Grove 5036493, Minnesota 5037779 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Minneapolis 5037649, Minnesota 5037779 55407
Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Minneapolis 5037649, Minnesota 5037779 55415
Monticello Cancer Center
Monticello 5038045, Minnesota 5037779 55362
Monticello 5038045, Minnesota 5037779 55362
North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779 55422
Robbinsdale 5043439, Minnesota 5037779 55422
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud 5044407, Minnesota 5037779 56303
Saint Cloud 5044407, Minnesota 5037779 56303
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Saint Louis Park 5045021, Minnesota 5037779 55416
Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Saint Paul 5045360, Minnesota 5037779 55101
United Hospital
Saint Paul 5045360, Minnesota 5037779 55102
Saint Paul 5045360, Minnesota 5037779 55102
Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779 55072
Sandstone 5045908, Minnesota 5037779 55072
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779 55082
Stillwater 5048814, Minnesota 5037779 55082
Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779 55792
Virginia 5051468, Minnesota 5037779 55792
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779 55387
Waconia 5051640, Minnesota 5037779 55387
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Siteman Cancer Center at Saint Peters Hospital
City of Saint Peters 4407237, Missouri 4398678 63376
City of Saint Peters 4407237, Missouri 4398678 63376
Siteman Cancer Center at West County Hospital
Creve Coeur 4382837, Missouri 4398678 63141
Creve Coeur 4382837, Missouri 4398678 63141
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Kansas City 4393217, Missouri 4398678 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Lee's Summit 4394870, Missouri 4398678 64064
University of Kansas Cancer Center at North Kansas City Hospital
North Kansas City 4400860, Missouri 4398678 64116
North Kansas City 4400860, Missouri 4398678 64116
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Washington University School of Medicine
St Louis 4407066, Missouri 4398678 63110
St Louis 4407066, Missouri 4398678 63110
Siteman Cancer Center-South County
St Louis 4407066, Missouri 4398678 63129
St Louis 4407066, Missouri 4398678 63129
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Siteman Cancer Center at Christian Hospital
St Louis 4407066, Missouri 4398678 63136
St Louis 4407066, Missouri 4398678 63136
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Billings 5640350, Montana 5667009 59101
Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Bozeman 5641727, Montana 5667009 59715
Renown Regional Medical Center
Reno 5511077, Nevada 5509151 89502
Reno 5511077, Nevada 5509151 89502
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Lebanon 5088597, New Hampshire 5090174 03756
Englewood Hospital and Medical Center
Englewood 5097672, New Jersey 5101760 07631
Englewood 5097672, New Jersey 5101760 07631
Contact:
Site Public Contact
201-894-3456
Site Public Contact
201-894-3456
Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760 07302
Jersey City 5099836, New Jersey 5101760 07302
Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Livingston 5100572, New Jersey 5101760 07039
Monmouth Medical Center
Long Branch 5100619, New Jersey 5101760 07740
Long Branch 5100619, New Jersey 5101760 07740
Jersey Shore Medical Center
Neptune City 5101687, New Jersey 5101760 07753
Neptune City 5101687, New Jersey 5101760 07753
Contact:
Site Public Contact
732-776-4240
Site Public Contact
732-776-4240
Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356
Site Public Contact
732-235-7356
Rutgers New Jersey Medical School
Newark 5101798, New Jersey 5101760 07101
Newark 5101798, New Jersey 5101760 07101
Contact:
Site Public Contact
732-235-7356
Site Public Contact
732-235-7356
Community Medical Center
Toms River 4504476, New Jersey 5101760 08755
Toms River 4504476, New Jersey 5101760 08755
Sands Cancer Center
Canandaigua 5111405, New York 5128638 14424
Canandaigua 5111405, New York 5128638 14424
Contact:
Site Public Contact
585-396-6161
Site Public Contact
585-396-6161
Noyes Memorial Hospital/Myers Cancer Center
Dansville 5114492, New York 5128638 14437
Dansville 5114492, New York 5128638 14437
Northwell Health/Center for Advanced Medicine
Lake Success 5123853, New York 5128638 11042
Lake Success 5123853, New York 5128638 11042
Contact:
Site Public Contact
516-734-8896
Site Public Contact
516-734-8896
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
New York 5128581, New York 5128638 10032
University of Rochester
Rochester 5134086, New York 5128638 14642
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Chapel Hill 4460162, North Carolina 4482348 27599
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
Akron 5145476, Ohio 5165418 44307
Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Centerville 4508204, Ohio 5165418 45459
Adena Regional Medical Center
Chillicothe 4828890, Ohio 5165418 45601
Chillicothe 4828890, Ohio 5165418 45601
University of Cincinnati Cancer Center-UC Medical Center
Cincinnati 4508722, Ohio 5165418 45219
Cincinnati 4508722, Ohio 5165418 45219
Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
Cincinnati 4508722, Ohio 5165418 45220
Bethesda North Hospital
Cincinnati 4508722, Ohio 5165418 45242
Cincinnati 4508722, Ohio 5165418 45242
MetroHealth Medical Center
Cleveland 5150529, Ohio 5165418 44109
Cleveland 5150529, Ohio 5165418 44109
Cleveland Clinic Foundation
Cleveland 5150529, Ohio 5165418 44195
Cleveland 5150529, Ohio 5165418 44195
Ohio State University Comprehensive Cancer Center
Columbus 4509177, Ohio 5165418 43210
Columbus 4509177, Ohio 5165418 43210
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320
Site Public Contact
937-276-8320
Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Dayton 4509884, Ohio 5165418 45415
Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Franklin 4512203, Ohio 5165418 45005-1066
Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515
Site Public Contact
937-569-7515
ProMedica Flower Hospital
Sylvania 5173572, Ohio 5165418 43560
Sylvania 5173572, Ohio 5165418 43560
ProMedica Toledo Hospital/Russell J Ebeid Children's Hospital
Toledo 5174035, Ohio 5165418 43606
Toledo 5174035, Ohio 5165418 43606
Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Troy 5174358, Ohio 5165418 45373
University of Cincinnati Cancer Center-West Chester
West Chester 4520522, Ohio 5165418 45069
West Chester 4520522, Ohio 5165418 45069
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma Cancer Specialists and Research Institute-Tulsa
Tulsa 4553433, Oklahoma 4544379 74146
Tulsa 4553433, Oklahoma 4544379 74146
Contact:
Site Public Contact
918-505-3200
Site Public Contact
918-505-3200
Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Newberg 5742726, Oregon 5744337 97132
Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Portland 5746545, Oregon 5744337 97210
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Portland 5746545, Oregon 5744337 97225
Kaiser Permanente Northwest
Portland 5746545, Oregon 5744337 97227
Portland 5746545, Oregon 5744337 97227
Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927 18103
Allentown 5178127, Pennsylvania 6254927 18103
UPMC Altoona
Altoona 5178195, Pennsylvania 6254927 16601
Altoona 5178195, Pennsylvania 6254927 16601
UPMC Hillman Cancer Center Erie
Erie 5188843, Pennsylvania 6254927 16505
Erie 5188843, Pennsylvania 6254927 16505
UPMC Cancer Center at UPMC Horizon
Farrell 5189377, Pennsylvania 6254927 16121
Farrell 5189377, Pennsylvania 6254927 16121
UPMC Cancer Centers - Arnold Palmer Pavilion
Greensburg 5192029, Pennsylvania 6254927 15601
Greensburg 5192029, Pennsylvania 6254927 15601
Contact:
Site Public Contact
724-838-1900
Site Public Contact
724-838-1900
UPMC Hillman Cancer Center in Greenville/UPMC Horizon
Greenville 5192019, Pennsylvania 6254927 16125
Greenville 5192019, Pennsylvania 6254927 16125
Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Hershey 5193342, Pennsylvania 6254927 17033-0850
Jefferson Hospital
Jefferson Hills 5195297, Pennsylvania 6254927 15025
Jefferson Hills 5195297, Pennsylvania 6254927 15025
UPMC-Johnstown/John P. Murtha Regional Cancer Center
Johnstown 5195561, Pennsylvania 6254927 15901
Johnstown 5195561, Pennsylvania 6254927 15901
Contact:
Site Public Contact
814-534-4724
Site Public Contact
814-534-4724
Forbes Hospital
Monroeville 5201734, Pennsylvania 6254927 15146
Monroeville 5201734, Pennsylvania 6254927 15146
Contact:
Site Public Contact
412-858-7746
Site Public Contact
412-858-7746
Allegheny General Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15212
Pittsburgh 5206379, Pennsylvania 6254927 15212
Contact:
Site Public Contact
877-284-2000
Site Public Contact
877-284-2000
University of Pittsburgh Cancer Institute (UPCI)
Pittsburgh 5206379, Pennsylvania 6254927 15232
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-647-8073
Site Public Contact
412-647-8073
UPMC-Shadyside Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15232
Pittsburgh 5206379, Pennsylvania 6254927 15232
Contact:
Site Public Contact
412-621-2334
Site Public Contact
412-621-2334
UPMC-Passavant Hospital
Pittsburgh 5206379, Pennsylvania 6254927 15237
Pittsburgh 5206379, Pennsylvania 6254927 15237
Contact:
Site Public Contact
412-367-6454
Site Public Contact
412-367-6454
Reading Hospital
West Reading 5218867, Pennsylvania 6254927 19611
West Reading 5218867, Pennsylvania 6254927 19611
Contact:
Site Public Contact
610-988-9323
Site Public Contact
610-988-9323
Wexford Health and Wellness Pavilion
Wexford 5219062, Pennsylvania 6254927 15090
Wexford 5219062, Pennsylvania 6254927 15090
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Roper Hospital
Charleston 4574324, South Carolina 4597040 29401
Charleston 4574324, South Carolina 4597040 29401
Charleston Oncology - Roper
Charleston 4574324, South Carolina 4597040 29403
Charleston 4574324, South Carolina 4597040 29403
Bon Secours Saint Francis Hospital
Charleston 4574324, South Carolina 4597040 29414
Charleston 4574324, South Carolina 4597040 29414
Charleston Oncology - Saint Francis
Charleston 4574324, South Carolina 4597040 29414
Charleston 4574324, South Carolina 4597040 29414
Avera Cancer Institute at Pierre
Pierre 5767918, South Dakota 5769223 57501
Pierre 5767918, South Dakota 5769223 57501
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Avera Cancer Institute
Sioux Falls 5231851, South Dakota 5769223 57105
Sioux Falls 5231851, South Dakota 5769223 57105
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Avera Cancer Institute at Yankton
Yankton 5233053, South Dakota 5769223 57078
Yankton 5233053, South Dakota 5769223 57078
Parkland Memorial Hospital
Dallas 4684888, Texas 4736286 75235
Dallas 4684888, Texas 4736286 75235
UT Southwestern/Simmons Cancer Center-Dallas
Dallas 4684888, Texas 4736286 75390
Dallas 4684888, Texas 4736286 75390
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Ben Taub General Hospital
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-873-2000
Site Public Contact
713-873-2000
Memorial Hermann Texas Medical Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-792-3245
Site Public Contact
713-792-3245
Memorial Hermann Northeast Hospital
Humble 4699442, Texas 4736286 77338
Humble 4699442, Texas 4736286 77338
Memorial Hermann The Woodlands Hospital
The Woodlands 4736476, Texas 4736286 77380
The Woodlands 4736476, Texas 4736286 77380
American Fork Hospital / Huntsman Intermountain Cancer Center
American Fork 5844096, Utah 5549030 84003
American Fork 5844096, Utah 5549030 84003
Sandra L Maxwell Cancer Center
Cedar City 5536630, Utah 5549030 84720
Cedar City 5536630, Utah 5549030 84720
Logan Regional Hospital
Logan 5777544, Utah 5549030 84321
Logan 5777544, Utah 5549030 84321
Intermountain Medical Center
Murray 5778755, Utah 5549030 84107
Murray 5778755, Utah 5549030 84107
McKay-Dee Hospital Center
Ogden 5779206, Utah 5549030 84403
Ogden 5779206, Utah 5549030 84403
Utah Valley Regional Medical Center
Provo 5780026, Utah 5549030 84604
Provo 5780026, Utah 5549030 84604
Riverton Hospital
Riverton 5780557, Utah 5549030 84065
Riverton 5780557, Utah 5549030 84065
LDS Hospital
Salt Lake City 5780993, Utah 5549030 84143
Salt Lake City 5780993, Utah 5549030 84143
Saint George Regional Medical Center
St. George 5546220, Utah 5549030 84770
St. George 5546220, Utah 5549030 84770
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners 5233780, Vermont 5242283 05602
Berlin Corners 5233780, Vermont 5242283 05602
Contact:
Site Public Contact
802-225-5400
Site Public Contact
802-225-5400
University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Burlington 5234372, Vermont 5242283 05401
University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283 05405
Burlington 5234372, Vermont 5242283 05405
Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Saint Johnsbury 5240656, Vermont 5242283 05819
Inova Alexandria Hospital
Alexandria 4744091, Virginia 6254928 22304
Alexandria 4744091, Virginia 6254928 22304
Inova Schar Cancer Institute
Fairfax 4758023, Virginia 6254928 22031
Fairfax 4758023, Virginia 6254928 22031
Inova Fair Oaks Hospital
Fairfax 4758023, Virginia 6254928 22033
Fairfax 4758023, Virginia 6254928 22033
Bon Secours Memorial Regional Medical Center
Mechanicsville 4772566, Virginia 6254928 23116
Mechanicsville 4772566, Virginia 6254928 23116
Bon Secours Saint Francis Medical Center
Midlothian 4772943, Virginia 6254928 23114
Midlothian 4772943, Virginia 6254928 23114
Bon Secours Saint Mary's Hospital
Richmond 4781708, Virginia 6254928 23226
Richmond 4781708, Virginia 6254928 23226
Henrico Doctor's Hospital
Richmond 4781708, Virginia 6254928 23229
Richmond 4781708, Virginia 6254928 23229
Contact:
Site Public Contact
804-591-4152
Site Public Contact
804-591-4152
Bon Secours Cancer Institute at Reynolds Crossing
Richmond 4781708, Virginia 6254928 23230
Richmond 4781708, Virginia 6254928 23230
VCU Massey Cancer Center at Stony Point
Richmond 4781708, Virginia 6254928 23235
Richmond 4781708, Virginia 6254928 23235
VCU Massey Comprehensive Cancer Center
Richmond 4781708, Virginia 6254928 23298
Richmond 4781708, Virginia 6254928 23298
Virginia Mason Medical Center
Seattle 5809844, Washington 5815135 98101
Seattle 5809844, Washington 5815135 98101
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Vancouver 5814616, Washington 5815135 98684
Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Morgantown 4815352, West Virginia 4826850 26506
Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Burlington 5247214, Wisconsin 5279468 53105
Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Germantown 5254218, Wisconsin 5279468 53022
Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Grafton 5254739, Wisconsin 5279468 53024
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54301
Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Green Bay 5254962, Wisconsin 5279468 54311
Essentia Health-Hayward Clinic
Hayward 5255882, Wisconsin 5279468 54843
Hayward 5255882, Wisconsin 5279468 54843
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
Johnson Creek 5257996, Wisconsin 5279468 53038
Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Kenosha 5258393, Wisconsin 5279468 53142
Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468 54601
La Crosse 5258957, Wisconsin 5279468 54601
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Madison 5261457, Wisconsin 5279468 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Madison 5261457, Wisconsin 5279468 53792
Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Marinette 5261852, Wisconsin 5279468 54143
Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
Milwaukee 5263045, Wisconsin 5279468 53209
Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Milwaukee 5263045, Wisconsin 5279468 53215
Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Milwaukee 5263045, Wisconsin 5279468 53233
ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Mukwonago 5263965, Wisconsin 5279468 53149
Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468 54017
New Richmond 5264475, Wisconsin 5279468 54017
ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Oshkosh 5265838, Wisconsin 5279468 54904
Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
Racine 5268249, Wisconsin 5279468 53406
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Essentia Health-Spooner Clinic
Spooner 5274034, Wisconsin 5279468 54801
Spooner 5274034, Wisconsin 5279468 54801
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
Summit, Wisconsin 5279468 53066
Essentia Health Saint Mary's Hospital - Superior
Superior 5275191, Wisconsin 5279468 54880
Superior 5275191, Wisconsin 5279468 54880
Contact:
Site Public Contact
701-364-6272
Site Public Contact
701-364-6272
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers 5276609, Wisconsin 5279468 54241
Two Rivers 5276609, Wisconsin 5279468 54241
UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Waukesha 5278052, Wisconsin 5279468 53188
Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
Wauwatosa 5278159, Wisconsin 5279468 53226
Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
West Allis 5278420, Wisconsin 5279468 53227
More Details
- NCT ID
- NCT05095376
- Status
- Recruiting
- Sponsor
- NRG Oncology
Detailed Description
PRIMARY OBJECTIVE: I. To determine if the regimen with the two alkylating agents temozolomide and lomustine with radiotherapy (RT) significantly prolongs overall survival (OS) versus (vs.) standard chemoradiotherapy with temozolomide in patients with newly diagnosed glioblastoma (GBM) with MGMT promoter methylation. SECONDARY OBJECTIVES: I. To determine if the regimen with the two alkylating agents temozolomide and lomustine with radiotherapy (RT) significantly prolongs progression-free survival (PFS) vs. standard chemoradiotherapy with temozolomide in patients with newly diagnosed GBM with MGMT promoter methylation. II. To compare the two different chemotherapy regimens on patient-reported outcomes (PROs), as measured by the MD Anderson Symptom Inventory - Brain Tumor (MDASI-BT) in patients with newly diagnosed GBM with MGMT promoter methylation. III. To determine if the regimen with the two alkylating agents temozolomide and lomustine with radiotherapy (RT) is associated with inferior short-term change in PROs as measured by MDASI-BT vs. standard chemoradiotherapy with temozolomide in patients with newly diagnosed GBM with MGMT promoter methylation. IV. To assess toxicity in the two different chemotherapy regimens. EXPLORATORY OBJECTIVES: I. To assess the association between absolute lymphocyte counts and outcomes. II. To assess the association between CD4+ lymphocyte counts and outcomes. III. To compare the two different chemotherapy regimens in terms of long-term PROs as measured by MDASI-BT at years 1 and 2. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo radiation therapy 5 days per week and receive temozolomide orally (PO) once daily (QD) for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients then receive temozolomide PO QD on days 1-5 of each cycle. Treatment repeats every 28 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo magnetic resonance imaging (MRI) throughout the trial. ARM II: Patients undergo radiation therapy 5 days per week for 6 weeks in the absence of disease progression or unacceptable toxicity. Patients also receive lomustine PO on day 1 of each cycle and temozolomide PO QD on days 2-6 of each cycle. Treatment repeats every 42 days for 6 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo MRI throughout the trial. After completion of study treatment, patients are followed up every 3 months for year 1, every 4 months for year 2, and then every 6 months thereafter.