Phase 1b Study of SL-172154 Administered With Combination Agent(s) in Subjects With Ovarian Cancers
Purpose
SL03-OHD-105 is an open-label, multicenter, phase 1b trial designed to evaluate SL-172154 administered in combination with pegylated liposomal doxorubicin (PLD) or mirvetuximab soravtansine (MIRV) in patients with platinum resistant ovarian cancer. Approximately 102 patients will be enrolled in this study in two phases: dose escalation and dose expansion.
Conditions
- Platinum-resistant Ovarian Cancer
- Fallopian Tube Cancer
- Epithelial Ovarian Cancer
- Ovarian Cancer
- Platinum-Resistant Fallopian Tube Carcinoma
- Platinum-Resistant Primary Peritoneal Carcinoma
- Primary Peritoneal Carcinoma
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Genders
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Subject has voluntarily agreed to participate by giving written informed consent in accordance with ICH/GCP guidelines and applicable local regulations. 2. Age ≥18 years 3. [PLD Cohort] Subject has a histologically confirmed diagnosis of high grade EOC, primary peritoneal cancer, or fallopian tube cancer. Non-epithelial tumors and ovarian tumors with low malignant potential are excluded. 4. [PLD Cohort] Subject must have platinum-resistant disease, defined as radiologic disease progression within 180 days (6 months) following the last administered dose of platinum therapy. Subjects that are primary platinum-refractory, defined by progressing during or within 1 month of upfront platinum therapy, are excluded. 5. [PLD Cohort] Subjects must have received no more than 1 prior line of systemic anticancer therapy for platinum-resistant disease and have either received bevacizumab, be medically-ineligible for bevacizumab, or bevacizumab not indicated per local standard of care. 6. [MIRV Cohort] Subject has a histologically confirmed diagnosis of high grade serous EOC, primary peritoneal cancer, or fallopian tube cancer. Non-epithelial tumors and ovarian tumors with low malignant potential are excluded. 7. [MIRV Cohort] Subject must have platinum-resistant disease as defined by: - Subjects who have only had 1 line of platinum-based therapy must have received at least 4 cycles of platinum, must have had a response (complete response/remission [CR] or partial response/remission [PR]) and then progressed between >3 months and ≤6 months after the date of the last dose of platinum. - Subjects who have received 2 or 3 lines of platinum therapy must have progressed on or within 6 months after the date of the last dose of platinum. - Patients who are platinum refractory during front-line treatment are excluded [primary platinum-refractory disease, defined as disease that did not respond to (CR or PR) or has progressed within 3 months of the last dose of first-line platinum-containing chemotherapy] 8. [MIRV Cohort] Subjects must have received at least 1 but no more than 3 prior systemic lines of anticancer therapy, including at least 1 line of therapy containing bevacizumab or be medically-ineligible for bevacizumab. 9. [MIRV Cohort] Willing to provide an archival tumor tissue block or slides or undergo procedure to obtain new biopsy using a low-risk, medically routine procedure for IHC confirmation of FRα positivity. 10. [MIRV Cohort] Subject's tumor must be positive for FRα expression as defined by the Ventana FOLR1 Assay. 11. Eastern Cooperative Oncology Group Performance Status (ECOG PS) of 0 or 1. 12. Measurable disease by RECIST v1.1 using radiologic assessment. 13. Adequate organ and hematologic function 14. Subjects must have stabilized or recovered (Grade 1 or baseline) from all prior anti-cancer therapy-related toxicities. 15. [MIRV and PLD Cohorts, Dose Expansion only] Willing to consent to 1 mandatory pre-treatment and 1 on-treatment tumor biopsy, unless there is excessive risk from the procedure as determined by the investigator
Exclusion Criteria
- Prior treatment with a signal-regulatory protein alpha (SIRPα) targeting agent, anti-CD47 agent or CD40 agonist. 2. [PLD Cohort] Prior treatment with doxorubicin or PLD 3. [MIRV Cohort] Prior treatment with MIRV or another FRα-targeting agent 4. Any anti-cancer therapy within the time intervals specified per protocol. 5. Concurrent chemotherapy, immunotherapy, biologic or hormonal therapy for cancer treatment is prohibited. 6. Receipt of live attenuated vaccine (including live attenuated vaccines for COVID-19) within 28 days of the first dose of study treatment. 7. Current or prior use of systemic immunosuppressive medication within 7 days prior to first dose of study treatment. 8. [MIRV Cohort] Requires use of folate-containing supplements (e.g., folate deficiency) 9. Active or documented history of autoimmune disease, history of multiple sclerosis (MS) or other demyelinating disease and/or Lambert-Eaton syndrome (paraneoplastic syndrome). Exceptions include controlled Type I diabetes, vitiligo, alopecia areata or hypo/hyperthyroidism. 10. Ongoing or active infection (e.g., no systemic antimicrobial therapy for treatment of infection within 5 days of D1 of study treatment). 11. Known severe hypersensitivity to the active drug substance or to any of the excipients for the agents to be administered or known hypersensitivity to Chinese hamster ovary cell products. 12. Severe gastrointestinal conditions. 13. Clinically significant or uncontrolled cardiovascular disease 14. [MIRV Cohort] History of cirrhotic liver disease (Child-Pugh Class B or C) 15. [MIRV Cohort] Active or chronic corneal disorders, history of corneal transplantation, or active ocular conditions requiring ongoing treatment/monitoring, such as uncontrolled glaucoma, wet age-related macular degeneration requiring intravitreal injections, active diabetic retinopathy with macular edema, macular degeneration, presence of papilledema, and/or monocular vision. 16. Previous clinical diagnosis of noninfectious interstitial lung disease (ILD), including noninfectious pneumonia. 17. Untreated CNS or leptomeningeal metastases. 18. Another malignancy that requires active therapy and that, in the opinion of the investigator and Sponsor, would interfere with monitoring of radiologic assessments of response to the study treatment. 19. Has undergone allogeneic stem cell transplantation or organ transplantation. 20. Known history or positive test for human immunodeficiency virus (HIV), or positive test for hepatitis B (positive for hepatitis B surface antigen [HBsAg]) or hepatitis C virus ([HCV]
Study Design
- Phase
- Phase 1
- Study Type
- Interventional
- Allocation
- Non-Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Experimental Pegylated Liposomal Doxorubicin + SL-172154 (SIRPα-Fc-CD40L) |
Pegylated Liposomal Doxorubicin (PLD) will be administered via intravenous administration + SL-172154 (SIRPα-Fc-CD40L) will be administered via intravenous administration. |
|
|
Experimental Mirvetuximab + SL-172154 (SIRPα-Fc-CD40L) |
Mirvetuximab (MIRV) will be administered via intravenous administration + SL-172154 (SIRPα-Fc-CD40L) will be administered via intravenous administration |
|
Recruiting Locations
University of Arkansas for Medical sciences
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
City of Hope
Duarte, California 91010
Duarte, California 91010
Contact:
Lindsay Kilpatrick
626-471-9200
Lindsay Kilpatrick
626-471-9200
Robert H.Lurie ComprehensiveCancer Center, Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
Contact:
Jonathan Parker
312-695-4511
Jonathan Parker
312-695-4511
Norton Cancer Institute
Louisville, Kentucky 40202
Louisville, Kentucky 40202
START Midwest
Grand Rapids, Michigan 49546
Grand Rapids, Michigan 49546
Contact:
Shannon Fabrie
616-954-5550
Shannon Fabrie
616-954-5550
Columbia University
New York, New York 10032
New York, New York 10032
Stephenson Cancer Center, OU Health/ Sarah Cannon Research Institute
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Contact:
Zachary Chandler, MA
405-271-8001
Zachary Chandler, MA
405-271-8001
UPMC Hillman Cancer Center
Pittsburgh, Pennsylvania 15232
Pittsburgh, Pennsylvania 15232
Medical University of South Carolina
Charleston, South Carolina 29425
Charleston, South Carolina 29425
Sarah Cannon Research Institute
Nashville, Tennessee 37203
Nashville, Tennessee 37203
Contact:
Eris Steele
615-329-7305
Eris Steele
615-329-7305
More Details
- NCT ID
- NCT05483933
- Status
- Recruiting
- Sponsor
- Shattuck Labs, Inc.
Detailed Description
Study SL03-OHD-105 is an open-label, multicenter, phase 1b trial designed to evaluate the safety, pharmacokinetics, pharmacodynamic effects, and preliminary anti-tumor activity of SL-172154 administered in combination with either PLD or MIRV in subjects with platinum-resistant ovarian, primary peritoneal, or fallopian tube cancers. Patients will be appropriate for combination therapy for their next line of therapy. For the SL-172154 + MIRV cohort, patients' tumors must be positive for folate receptor alpha (FRα) as defined by the Ventana FOLR1 (Folate Receptor 1/Folate Receptor Alpha) Assay. The first portion of the study will evaluate the safety of increasing dose levels of SL-172154 in combination with either PLD or MIRV and establish a combination dose for both regimens to be further evaluated in two dose expansion cohorts. The study will consist of a 21-day screening period, a study treatment period until at least one of the study treatment discontinuation criteria is met, and a study follow-up period.