Effect of rTMS on Resting State Brain Activity in Tinnitus
One out of every five people experiences tinnitus (a ringing, buzzing, or roaring sound in the ear) ranging from mild to severe impairment. To date, there are no effective therapies available that have been shown to decrease tinnitus loudness. The purpose of this study is to develop a new treatment option for tinnitus using a technique called Repetitive Transcranial Magnetic Stimulation (rTMS), which will hopefully prove to be an effective means of alleviating or reducing the symptoms of tinnitus.
- Eligible Ages
- Between 19 Years and 89 Years
- Eligible Genders
- Accepts Healthy Volunteers
- Diagnosis of tinnitus established through a history and physical exam or review or records performed by the study physician
- Subjects 19-89 years of age
- Tinnitus present for at least 6 months and severe enough to seek medical attention
- Subjects taking SSRI's (a class of anti-depressant medications)and benzodiazepines (a class of anti-anxiety medications) for depression or anxiety related to tinnitus must be stable on their current dose for at least 3 months and must not alter their dose or medication during their involvement with this study
- Subjects must agree to avoid consuming alcohol within 72 hours of each rTMS session
- Female subjects of childbearing potential must demonstrate a negative pregnancy test during their initial clinic visit and must agree to use effective contraception during their participation in this study
- Subjects must sign an informed consent and agree to comply with study and follow-up procedures, including completion of all necessary questionnaires and testing, as well as, being video-recorded for safety purposes during rTMS sessions
- Subjects must speak and comprehend English adequately to understand and complete any study-related instructions and questionnaires
- Subjects or any of their 1st-degree relatives must not have been diagnosed with epilepsy
- Subjects must not have a history of seizure disorder or migraines
- Subjects must not have any history of a brain aneurysm, stroke, previous cranial neurosurgery, acoustic neuroma, glomus tumor, active Menniere's Disease, profound hearing loss (greater than 90 dB at 4000 Hz), or any major neurological or psychiatric disorders (excluding depression or anxiety related to tinnitus)
- Subjects must not have any history of a head injury that resulted in a loss of consciousness for more than 10 minutes
- Subjects must not have any metal implants or devices in the head or neck or a pacemaker.
- Subjects must not have severe claustrophobia if they are to have an MRI. Significant abnormalities must not be present on acquired or existing CT or MRI image of the head.
- Subjects must not be pregnant or refuse to utilize effective contraception during their participation in this study
- Subjects must not have any history of Bipolar Disease
- Study Type
- Intervention Model
- Single Group Assignment
- Primary Purpose
- Double (Participant, Investigator)
|All subjects complete the initial three weeks of rTMS sessions, which include 8 active sessions and 4 sham sessions. Subjects receive sham stimulation first to prevent carry forward effects of active treatment. Active and sham weeks are separated for each subject by an interval of no less than 21 days.||
|Subjects who respond to either week of active rTMS have the option of participating in a maintenance rTMS program involving up to 8 additional sessions of therapy, each consisting of 3 days of rTMS treatment. Maintenance sessions will be scheduled with three weeks separating each treatment.||
Little Rock, Arkansas 72205
- NCT ID
- University of Arkansas
Study ContactMark S Mennemeier, PhD
This research is being conducted at the University of Arkansas for Medical Sciences (UAMS). Up to 60 subjects, including males and females ages 19-89 years old and of all races, and with tinnitus severe enough to seek medical attention, will be enrolled in this study. All participants will be evaluated or medically reviewed by the study physician, Dr. Dornhoffer of the Hearing and Balance Clinic at UAMS, including a modified physical examination and hearing tests, prior to beginning therapy with rTMS in order to rule out any medically treatable causes of tinnitus. An MRI scan of the head may or may not be required, depending upon the results of this evaluation, in order to rule out specific middle ear pathologies.
This study will require participation in at least three weeks (4 weekdays per week) of rTMS sessions, including two active weeks and a sham (or placebo) week. There will be a three week washout period following each treatment week. At the completion of the three treatment weeks, subjects who have noticed an improvement in their tinnitus will have the option of participating in a maintenance rTMS program providing up to 8 additional weeks of treatment.