Regional Radiotherapy in Biomarker Low Risk Node Positive Breast Cancer
Purpose
The purpose of this study is to compare the effects on low risk breast cancer receiving usual care that includes regional radiation therapy, with receiving no regional radiation therapy. Researchers want to see if not giving this type of radiation treatment works as well at preventing breast cancer from coming back.
Condition
- Breast Cancer
Eligibility
- Eligible Ages
- Over 40 Years
- Eligible Genders
- Female
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Patients must have newly diagnosed histologically proven invasive carcinoma of the breast with no evidence of metastases.
- Patients must have been treated by BCS or mastectomy.
- Patients treated by BCS or mastectomy and axillary dissection must have 1-3 positive axillary nodes (macrometastases, > 2 mm).
- Patients treated by BCS and SLNB alone must have only 1-2 positive axillary nodes (macrometastases, > 2 mm).
- Patients treated by mastectomy and SLNB alone must have only 1 positive axillary node (macrometastases, > 2 mm).
- Patients must be ER ≥ 1% and HER2 negative on local testing
- Patients must have an Oncotype DX recurrence score <18
- Patient must consent to provision of, and investigator(s) must confirm access to and agree to submit to the CCTG Central Tumour Bank, a representative formalin fixed paraffin block of tumour tissue in order that the specific correlative marker assays described in the protocol may be conducted
- Patient must consent to provision of samples of blood in order that the specific correlative marker assays described in the protocol may be conducted.
- Patients must have had endocrine therapy initiated or planned for ≥ 5 years. Endocrine therapy can be given concurrently or following RT.
- Patients may or may not have had adjuvant chemotherapy.
- RT must be administered within 12 weeks of definitive surgery if the patient is not treated with chemotherapy. If adjuvant chemotherapy is given, RT must begin within 2-8 weeks after the last dose.
- Patient's ECOG performance status must be 0, 1 or 2.
- Patient's age must be ≥ 40 years.
- Patient's life expectancy is ≥10 years
- For the first 736 eligible English or French-speaking subjects who have agreed to optional questionnaire completion: Patient is able (i.e. sufficiently fluent) and willing to complete the quality of life, health utilities and lost productivity questionnaires in either English or French
- Patient consent must be appropriately obtained in accordance with applicable local and regulatory requirements
- Patients must be accessible for treatment and follow-up. Investigators must assure themselves the patients randomized on this trial will be available for complete documentation of the treatment, adverse events, and follow-up.
- In accordance with CCTG policy, protocol treatment is to begin within 3 weeks of patient randomization.
- Women of childbearing potential must have agreed to use an effective contraceptive method. A woman is considered to be of "childbearing potential" if she has had menses at any time in the preceding 12 consecutive months.
Exclusion Criteria
- Patients with nodal disease limited to micrometastases (pN1Mi, > 0.2 mm and ≤ 2 mm) or isolated tumour cells (pN0i+ < 0.2 mm).
- Any prior history, not including the index cancer, of ipsilateral invasive breast cancer or ipsilateral DCIS treated with radiation therapy. (Patients with synchronous or previous ipsilateral LCIS are eligible.)
- Synchronous or previous contralateral invasive breast cancer. (Patients with contralateral DCIS not treated with radiation are eligible.)
- History of non-breast malignancies except adequately treated non-melanoma skin cancers, in situ cancers treated by local excision or other cancers curatively treated with no evidence of disease for ≥ 5 years.
- Patients with pT3 or pT4 disease.
- Patients who are pregnant.
- Patients that have had prior ipsilateral chestwall/thoracic radiation.
- Patients treated with neoadjuvant chemo or endocrine therapy for breast cancer.
- Patients with serious non-malignant disease (e.g. cardiovascular, scleroderma etc.) which would preclude RT.
- Patients with any serious active or co-morbid medical conditions, laboratory abnormality, psychiatric illness, active or uncontrolled infections, or serious illnesses or medical conditions that would prevent the patient from participating or to be managed according to the protocol (according to investigator's decision).
Study Design
- Phase
- N/A
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator No Regional Radiotherapy |
A. Whole Breast Irradiation (WBI) following BCS or; B. No Radiotherapy (RT) following mastectomy |
|
|
Active Comparator Regional Radiotherapy |
A. WBI plus RT to the regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following BCS or; B. RT to the chestwall and regional nodes (supraclavicular, non-dissected axillary, and internal mammary) following mastectomy |
|
Recruiting Locations
University of Arkansas for Medical Sciences
Little Rock, Arkansas 72205
Little Rock, Arkansas 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Alta Bates Summit Medical Center-Herrick Campus
Berkeley, California 94704
Berkeley, California 94704
City of Hope Comprehensive Cancer Center
Duarte, California 91010
Duarte, California 91010
Fresno Cancer Center
Fresno, California 93720
Fresno, California 93720
Kaiser Permanente Oakland-Broadway
Oakland, California 94611
Oakland, California 94611
Kaiser Permanente-Rancho Cordova Cancer Center
Rancho Cordova, California 95670
Rancho Cordova, California 95670
Rohnert Park Cancer Center
Rohnert Park, California 94928
Rohnert Park, California 94928
The Permanente Medical Group-Roseville Radiation Oncology
Roseville, California 95678
Roseville, California 95678
Kaiser Permanente Medical Center - Santa Clara
Santa Clara, California 95051
Santa Clara, California 95051
City of Hope South Pasadena
South Pasadena, California 91030
South Pasadena, California 91030
Kaiser Permanente Cancer Treatment Center
South San Francisco, California 94080
South San Francisco, California 94080
Sutter Solano Medical Center/Cancer Center
Vallejo, California 94589
Vallejo, California 94589
University of Colorado Hospital
Aurora, Colorado 80045
Aurora, Colorado 80045
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
Penrose-Saint Francis Healthcare
Colorado Springs, Colorado 80907
Colorado Springs, Colorado 80907
UCHealth Memorial Hospital Central
Colorado Springs, Colorado 80909
Colorado Springs, Colorado 80909
Contact:
Site Public Contact
719-365-2406
Site Public Contact
719-365-2406
Memorial Hospital North
Colorado Springs, Colorado 80920
Colorado Springs, Colorado 80920
Contact:
Site Public Contact
719-364-6700
Site Public Contact
719-364-6700
Poudre Valley Hospital
Fort Collins, Colorado 80524
Fort Collins, Colorado 80524
Contact:
Site Public Contact
970-297-6150
Site Public Contact
970-297-6150
North Colorado Medical Center
Greeley, Colorado 80631
Greeley, Colorado 80631
McKee Medical Center
Loveland, Colorado 80539
Loveland, Colorado 80539
SCL Health Lutheran Medical Center
Wheat Ridge, Colorado 80033
Wheat Ridge, Colorado 80033
Yale University
New Haven, Connecticut 06520
New Haven, Connecticut 06520
Lawrence and Memorial Cancer Center
Waterford, Connecticut 06385
Waterford, Connecticut 06385
Helen F Graham Cancer Center
Newark, Delaware 19713
Newark, Delaware 19713
Christiana Care Health System-Christiana Hospital
Newark, Delaware 19718
Newark, Delaware 19718
UM Sylvester Comprehensive Cancer Center at Coral Gables
Coral Gables, Florida 33146
Coral Gables, Florida 33146
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UM Sylvester Comprehensive Cancer Center at Deerfield Beach
Deerfield Beach, Florida 33442
Deerfield Beach, Florida 33442
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
Broward Health Medical Center
Fort Lauderdale, Florida 33316
Fort Lauderdale, Florida 33316
Contact:
Site Public Contact
954-355-5346
Site Public Contact
954-355-5346
Memorial Regional Hospital/Joe DiMaggio Children's Hospital
Hollywood, Florida 33021
Hollywood, Florida 33021
University of Miami Miller School of Medicine-Sylvester Cancer Center
Miami, Florida 33136
Miami, Florida 33136
Contact:
Site Public Contact
305-243-2647
Site Public Contact
305-243-2647
UF Cancer Center at Orlando Health
Orlando, Florida 32806
Orlando, Florida 32806
Memorial Hospital West
Pembroke Pines, Florida 33028
Pembroke Pines, Florida 33028
Contact:
Site Public Contact
954-265-4325
Site Public Contact
954-265-4325
Moffitt Cancer Center
Tampa, Florida 33612
Tampa, Florida 33612
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia 31405
Savannah, Georgia 31405
Saint Alphonsus Cancer Care Center-Boise
Boise, Idaho 83706
Boise, Idaho 83706
Northwestern University
Chicago, Illinois 60611
Chicago, Illinois 60611
Rush University Medical Center
Chicago, Illinois 60612
Chicago, Illinois 60612
University of Illinois
Chicago, Illinois 60612
Chicago, Illinois 60612
Contact:
Site Public Contact
312-355-3046
Site Public Contact
312-355-3046
Swedish Covenant Hospital
Chicago, Illinois 60625
Chicago, Illinois 60625
Contact:
Site Public Contact
773-878-8200
Site Public Contact
773-878-8200
Advocate Illinois Masonic Medical Center
Chicago, Illinois 60657
Chicago, Illinois 60657
Contact:
Site Public Contact
773-296-5360
Site Public Contact
773-296-5360
Decatur Memorial Hospital
Decatur, Illinois 62526
Decatur, Illinois 62526
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois 60045
Lake Forest, Illinois 60045
OSF Saint Francis Medical Center
Peoria, Illinois 61637
Peoria, Illinois 61637
Memorial Medical Center
Springfield, Illinois 62781
Springfield, Illinois 62781
Contact:
Site Public Contact
217-788-3528
Site Public Contact
217-788-3528
Carle Cancer Center
Urbana, Illinois 61801
Urbana, Illinois 61801
IU Health West Hospital
Avon, Indiana 46123
Avon, Indiana 46123
IU Health Central Indiana Cancer Centers-Fishers
Fishers, Indiana 46037
Fishers, Indiana 46037
Contact:
Site Public Contact
317-356-2422
Site Public Contact
317-356-2422
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
IU Health Methodist Hospital
Indianapolis, Indiana 46202
Indianapolis, Indiana 46202
Community Cancer Center East
Indianapolis, Indiana 46219
Indianapolis, Indiana 46219
Community Cancer Center South
Indianapolis, Indiana 46227
Indianapolis, Indiana 46227
Community Cancer Center North
Indianapolis, Indiana 46256
Indianapolis, Indiana 46256
IU Health Ball Memorial Hospital
Muncie, Indiana 47303
Muncie, Indiana 47303
Contact:
Site Public Contact
765-751-5850
Site Public Contact
765-751-5850
Mercy Cancer Center-West Lakes
Clive, Iowa 50325
Clive, Iowa 50325
Mercy Medical Center - Des Moines
Des Moines, Iowa 50314
Des Moines, Iowa 50314
University of Kansas Cancer Center
Kansas City, Kansas 66160
Kansas City, Kansas 66160
University of Kansas Cancer Center-Overland Park
Overland Park, Kansas 66210
Overland Park, Kansas 66210
Ascension Via Christi Hospitals Wichita
Wichita, Kansas 67214
Wichita, Kansas 67214
Saint Elizabeth Medical Center South
Edgewood, Kentucky 41017
Edgewood, Kentucky 41017
The James Graham Brown Cancer Center at University of Louisville
Louisville, Kentucky 40202
Louisville, Kentucky 40202
Contact:
Site Public Contact
502-562-3429
Site Public Contact
502-562-3429
MaineHealth Coastal Cancer Treatment Center
Bath, Maine 04530
Bath, Maine 04530
Lafayette Family Cancer Center-EMMC
Brewer, Maine 04412
Brewer, Maine 04412
Contact:
Site Public Contact
800-987-3005
Site Public Contact
800-987-3005
Maine Medical Center-Bramhall Campus
Portland, Maine 04102
Portland, Maine 04102
Contact:
Site Public Contact
207-885-7565
Site Public Contact
207-885-7565
MaineHealth Cancer Care Center of York County
Sanford, Maine 04073
Sanford, Maine 04073
Contact:
Site Public Contact
207-459-1600
Site Public Contact
207-459-1600
Maine Medical Center- Scarborough Campus
Scarborough, Maine 04074
Scarborough, Maine 04074
Anne Arundel Medical Center
Annapolis, Maryland 21401
Annapolis, Maryland 21401
Greater Baltimore Medical Center
Baltimore, Maryland 21204
Baltimore, Maryland 21204
Contact:
Site Public Contact
443-849-3706
Site Public Contact
443-849-3706
Lahey Hospital and Medical Center
Burlington, Massachusetts 01805
Burlington, Massachusetts 01805
Contact:
Site Public Contact
781-744-8027
Site Public Contact
781-744-8027
Lowell General Hospital
Lowell, Massachusetts 01854
Lowell, Massachusetts 01854
University of Michigan Comprehensive Cancer Center
Ann Arbor, Michigan 48109
Ann Arbor, Michigan 48109
Contact:
Site Public Contact
800-865-1125
Site Public Contact
800-865-1125
Beaumont Hospital ? Dearborn
Dearborn, Michigan 48124
Dearborn, Michigan 48124
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Beaumont Hospital - Farmington Hills
Farmington Hills, Michigan 48336
Farmington Hills, Michigan 48336
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Spectrum Health at Butterworth Campus
Grand Rapids, Michigan 49503
Grand Rapids, Michigan 49503
Mercy Health Mercy Campus
Muskegon, Michigan 49444
Muskegon, Michigan 49444
Ascension Providence Hospitals - Novi
Novi, Michigan 48374
Novi, Michigan 48374
William Beaumont Hospital-Royal Oak
Royal Oak, Michigan 48073
Royal Oak, Michigan 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Ascension Providence Hospitals - Southfield
Southfield, Michigan 48075
Southfield, Michigan 48075
Munson Medical Center
Traverse City, Michigan 49684
Traverse City, Michigan 49684
William Beaumont Hospital - Troy
Troy, Michigan 48085
Troy, Michigan 48085
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Metro Health Hospital
Wyoming, Michigan 49519
Wyoming, Michigan 49519
Sanford Joe Lueken Cancer Center
Bemidji, Minnesota 56601
Bemidji, Minnesota 56601
Hennepin County Medical Center
Minneapolis, Minnesota 55415
Minneapolis, Minnesota 55415
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven, Mississippi 38671
Southhaven, Mississippi 38671
Saint Francis Medical Center
Cape Girardeau, Missouri 63703
Cape Girardeau, Missouri 63703
The University of Kansas Cancer Center-North
Kansas City, Missouri 64154
Kansas City, Missouri 64154
The University of Kansas Cancer Center-Lee's Summit
Lee's Summit, Missouri 64064
Lee's Summit, Missouri 64064
Missouri Baptist Medical Center
Saint Louis, Missouri 63131
Saint Louis, Missouri 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Benefis Healthcare- Sletten Cancer Institute
Great Falls, Montana 59405
Great Falls, Montana 59405
University of Nebraska Medical Center
Omaha, Nebraska 68198
Omaha, Nebraska 68198
New Hampshire Oncology Hematology PA-Concord
Concord, New Hampshire 03301
Concord, New Hampshire 03301
Contact:
Site Public Contact
603-224-2556
Site Public Contact
603-224-2556
Wentworth-Douglass Hospital
Dover, New Hampshire 03820
Dover, New Hampshire 03820
Contact:
Site Public Contact
603-740-2150
Site Public Contact
603-740-2150
New Hampshire Oncology Hematology PA-Hooksett
Hooksett, New Hampshire 03106
Hooksett, New Hampshire 03106
Contact:
Site Public Contact
800-339-6484
Site Public Contact
800-339-6484
The Cancer Institute of New Jersey Hamilton
Hamilton, New Jersey 08690
Hamilton, New Jersey 08690
Contact:
Site Public Contact
609-631-6946
Site Public Contact
609-631-6946
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey 08903
New Brunswick, New Jersey 08903
Contact:
Site Public Contact
732-235-8675
Site Public Contact
732-235-8675
Robert Wood Johnson University Hospital Somerset
Somerville, New Jersey 08876
Somerville, New Jersey 08876
Contact:
Site Public Contact
908-685-2481
Site Public Contact
908-685-2481
University of New Mexico Cancer Center
Albuquerque, New Mexico 87102
Albuquerque, New Mexico 87102
Lovelace Radiation Oncology
Albuquerque, New Mexico 87109
Albuquerque, New Mexico 87109
New Mexico Oncology Hematology Consultants
Albuquerque, New Mexico 87109
Albuquerque, New Mexico 87109
Memorial Medical Center - Las Cruces
Las Cruces, New Mexico 88011
Las Cruces, New Mexico 88011
Montefiore Medical Center-Einstein Campus
Bronx, New York 10461
Bronx, New York 10461
Montefiore Medical Center - Moses Campus
Bronx, New York 10467
Bronx, New York 10467
Mount Sinai Union Square
New York, New York 10003
New York, New York 10003
Mount Sinai Chelsea
New York, New York 10011
New York, New York 10011
Laura and Isaac Perlmutter Cancer Center at NYU Langone
New York, New York 10016
New York, New York 10016
Mount Sinai Hospital
New York, New York 10029
New York, New York 10029
Stony Brook University Medical Center
Stony Brook, New York 11794
Stony Brook, New York 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
Mission Hospital Inc-Memorial Campus
Asheville, North Carolina 28801
Asheville, North Carolina 28801
Hope Women's Cancer Centers-Asheville
Asheville, North Carolina 28816
Asheville, North Carolina 28816
CaroMont Regional Medical Center
Gastonia, North Carolina 28054
Gastonia, North Carolina 28054
Sanford Bismarck Medical Center
Bismarck, North Dakota 58501
Bismarck, North Dakota 58501
Mercy Medical Center
Canton, Ohio 44708
Canton, Ohio 44708
Contact:
Site Public Contact
888-293-4673
Site Public Contact
888-293-4673
Aultman Health Foundation
Canton, Ohio 44710
Canton, Ohio 44710
Ohio State University Comprehensive Cancer Center
Columbus, Ohio 43210
Columbus, Ohio 43210
The Mark H Zangmeister Center
Columbus, Ohio 43219
Columbus, Ohio 43219
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma 73104
Oklahoma City, Oklahoma 73104
Bryn Mawr Hospital
Bryn Mawr, Pennsylvania 19010
Bryn Mawr, Pennsylvania 19010
Christiana Care Health System-Concord Health Center
Chadds Ford, Pennsylvania 19317
Chadds Ford, Pennsylvania 19317
Saint Vincent Hospital
Erie, Pennsylvania 16544
Erie, Pennsylvania 16544
Contact:
Site Public Contact
814-452-5000
Site Public Contact
814-452-5000
Jefferson Hospital
Jefferson Hills, Pennsylvania 15025
Jefferson Hills, Pennsylvania 15025
Riddle Memorial Hospital
Media, Pennsylvania 19063
Media, Pennsylvania 19063
Forbes Hospital
Monroeville, Pennsylvania 15146
Monroeville, Pennsylvania 15146
Contact:
Site Public Contact
412-858-7746
Site Public Contact
412-858-7746
Paoli Memorial Hospital
Paoli, Pennsylvania 19301
Paoli, Pennsylvania 19301
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
Contact:
Site Public Contact
215-955-6084
Site Public Contact
215-955-6084
Allegheny General Hospital
Pittsburgh, Pennsylvania 15212
Pittsburgh, Pennsylvania 15212
Contact:
Site Public Contact
877-284-2000
Site Public Contact
877-284-2000
West Penn Hospital
Pittsburgh, Pennsylvania 15224
Pittsburgh, Pennsylvania 15224
Contact:
Site Public Contact
412-578-5000
Site Public Contact
412-578-5000
Wexford Health and Wellness Pavilion
Wexford, Pennsylvania 15090
Wexford, Pennsylvania 15090
Lankenau Medical Center
Wynnewood, Pennsylvania 19096
Wynnewood, Pennsylvania 19096
Women and Infants Hospital
Providence, Rhode Island 02905
Providence, Rhode Island 02905
Contact:
Site Public Contact
401-274-1122
Site Public Contact
401-274-1122
Greenville Health System Cancer Institute-Faris
Greenville, South Carolina 29605
Greenville, South Carolina 29605
Saint Francis Cancer Center
Greenville, South Carolina 29607
Greenville, South Carolina 29607
Greenville Health System Cancer Institute-Eastside
Greenville, South Carolina 29615
Greenville, South Carolina 29615
Greenville Health System Cancer Institute-Greer
Greer, South Carolina 29650
Greer, South Carolina 29650
Greenville Health System Cancer Institute-Seneca
Seneca, South Carolina 29672
Seneca, South Carolina 29672
Greenville Health System Cancer Institute-Spartanburg
Spartanburg, South Carolina 29307
Spartanburg, South Carolina 29307
Lexington Medical Center
West Columbia, South Carolina 29169
West Columbia, South Carolina 29169
Contact:
Site Public Contact
803-936-8050
Site Public Contact
803-936-8050
Sanford USD Medical Center - Sioux Falls
Sioux Falls, South Dakota 57117-5134
Sioux Falls, South Dakota 57117-5134
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis, Tennessee 38120
Memphis, Tennessee 38120
UT Southwestern/Simmons Cancer Center-Dallas
Dallas, Texas 75390
Dallas, Texas 75390
University of Texas Health Science Center at San Antonio
San Antonio, Texas 78229
San Antonio, Texas 78229
Farmington Health Center
Farmington, Utah 84025
Farmington, Utah 84025
Huntsman Cancer Institute/University of Utah
Salt Lake City, Utah 84112
Salt Lake City, Utah 84112
South Jordan Health Center
South Jordan, Utah 84009
South Jordan, Utah 84009
Augusta Health Center for Cancer and Blood Disorders
Fishersville, Virginia 22939
Fishersville, Virginia 22939
Contact:
Site Public Contact
540-332-5960
Site Public Contact
540-332-5960
Langlade Hospital and Cancer Center
Antigo, Wisconsin 54409
Antigo, Wisconsin 54409
Marshfield Medical Center-EC Cancer Center
Eau Claire, Wisconsin 54701
Eau Claire, Wisconsin 54701
Aurora Cancer Care-Grafton
Grafton, Wisconsin 53024
Grafton, Wisconsin 53024
Saint Vincent Hospital Cancer Center Green Bay
Green Bay, Wisconsin 54301
Green Bay, Wisconsin 54301
Saint Vincent Hospital Cancer Center at Saint Mary's
Green Bay, Wisconsin 54303
Green Bay, Wisconsin 54303
Aurora BayCare Medical Center
Green Bay, Wisconsin 54311
Green Bay, Wisconsin 54311
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin 53142
Kenosha, Wisconsin 53142
University of Wisconsin Hospital and Clinics
Madison, Wisconsin 53792
Madison, Wisconsin 53792
Contact:
Site Public Contact
800-622-8922
Site Public Contact
800-622-8922
Aurora Bay Area Medical Group-Marinette
Marinette, Wisconsin 54143
Marinette, Wisconsin 54143
Marshfield Medical Center-Marshfield
Marshfield, Wisconsin 54449
Marshfield, Wisconsin 54449
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin 53215
Milwaukee, Wisconsin 53215
Aurora Sinai Medical Center
Milwaukee, Wisconsin 53233
Milwaukee, Wisconsin 53233
Marshfield Clinic-Minocqua Center
Minocqua, Wisconsin 54548
Minocqua, Wisconsin 54548
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh, Wisconsin 54904
Oshkosh, Wisconsin 54904
Marshfield Medical Center-Rice Lake
Rice Lake, Wisconsin 54868
Rice Lake, Wisconsin 54868
HSHS Saint Nicholas Hospital
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin 53081
Sheboygan, Wisconsin 53081
Marshfield Clinic Stevens Point Center
Stevens Point, Wisconsin 54482
Stevens Point, Wisconsin 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay, Wisconsin 54235-1495
Sturgeon Bay, Wisconsin 54235-1495
Aurora Medical Center in Summit
Summit, Wisconsin 53066
Summit, Wisconsin 53066
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin 54241
Two Rivers, Wisconsin 54241
Aspirus Regional Cancer Center
Wausau, Wisconsin 54401
Wausau, Wisconsin 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Aurora West Allis Medical Center
West Allis, Wisconsin 53227
West Allis, Wisconsin 53227
Diagnostic and Treatment Center
Weston, Wisconsin 54476
Weston, Wisconsin 54476
More Details
- NCT ID
- NCT03488693
- Status
- Recruiting
- Sponsor
- Canadian Cancer Trials Group
Detailed Description
Women with node positive breast cancer normally will receive endocrine therapy and some may receive chemotherapy to help prevent the cancer from coming back. Many women will also receive radiotherapy to the whole breast/chest area and the surrounding lymph glands (called regional radiotherapy). No one really knows whether patients with low risk breast cancer need to receive regional radiotherapy. Some women may be getting regional radiotherapy who do not need it. These women may be exposed to the side effects of their treatment without benefit.