Comparing Combinations of Drugs to Treat Newly Diagnosed Multiple Myeloma (NDMM) When a Stem Cell Transplant is Not a Medically Suitable Treatment
Purpose
This phase III trial compares three-drug induction regimens followed by double-or single-drug maintenance therapy for the treatment of newly diagnosed multiple myeloma in patients who are not receiving a stem cell transplant and are considered frail or intermediate-fit based on age, comorbidities, and functional status. Treatment for multiple myeloma includes initial treatment (induction) which is the first treatment a patient receives for cancer followed by ongoing treatment (maintenance) which is given after initial treatment to help keep the cancer from coming back. There are three combinations of four different drugs being studied. Bortezomib is one of the drugs that may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Lenalidomide works by helping bone marrow to produce normal blood cells and killing cancer cells. Anti-inflammatory drugs, such as dexamethasone, lower the body's immune response and are used with other drugs in the treatment of some types of cancer. Daratumumab and hyaluronidase-fihj is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. Patients receive 1 of 3 combinations of these drugs for treatment to determine which combination of study drugs works better to shrink and control multiple myeloma.
Condition
- Plasma Cell Myeloma
Eligibility
- Eligible Ages
- All ages
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Participants must have documented multiple myeloma satisfying standard International Myeloma Working Group (IMWG) diagnostic criteria within 28 days prior to registration - Participants must have measurable disease within 28 days prior to registration as defined by any of the following: - Immunoglobulin (Ig) G myeloma (serum monoclonal paraprotein [M-protein] level >= 0.5 gram/deciliter [g/dL] or urine M-protein level >= 200 milligram[mg]/24 hours[hrs]); OR - IgA, IgM, IgD, or IgE multiple myeloma (serum M-protein level >= 0.2 g/dL or urine M-protein level >= 200 mg/24 hrs); OR - Light chain multiple myeloma (serum immunoglobulin free light chain >= 10 mg/dL and abnormal serum immunoglobulin kappa lambda free light chain ratio) - All disease must be assessed and documented on the baseline/pre-registration tumor assessment form - Participants must have a calculated myeloma frailty index (Myeloma Frailty Score Calculator; http://www.myelomafrailtyscorecalculator.net/) categorized as frail or intermediate fit (regardless of age) within 28 days prior to registration - For Participants Meeting "Frail" Status: - Participants with any degree of kidney dysfunction are allowed; however, participants on dialysis are not eligible - For Participants Meeting "Frail" Status: - Hemoglobin >= 7 g/dL (must be performed within 28 days prior to registration) - Note: growth factor and transfusion utilization are allowed if cytopenias are considered secondary to bone marrow involvement from MM) - For Participants Meeting "Frail" Status: - Platelets >= 50 x 10^9/L (must be performed within 28 days prior to registration) - Note: growth factor and transfusion utilization are allowed if cytopenias are considered secondary to bone marrow involvement from MM) - For Participants Meeting "Frail" Status: - Absolute neutrophil count (ANC) >= 0.75 x10^9/L (must be performed within 28 days prior to registration) - Note: growth factor and transfusion utilization are allowed if cytopenias are considered secondary to bone marrow involvement from MM) - For Participants Meeting "Intermediate Fit" Status, one or more of the following criteria must be present: - Kidney dysfunction showing calculated creatinine clearance (CrCl) <30 ml/min. - Actual lab serum creatinine value with a minimum of 0.7 mg/dL. - Participants must have bone marrow function assessed and meet the below criteria ranges: - Hemoglobin between 7-8 g/dL, OR - Platelets between 50-75 x10^9/L, OR - ANC between 0.75-1 x10^9/L - Note: growth factor and transfusion utilization are allowed as long as cytopenias are considered secondary to bone marrow involvement from MM) - Revised International Staging System (R-ISS) stage III disease - Note: All labs must be performed within 28 days prior to registration - Participants must have a complete medical history and physical exam within 28 days prior to registration - Participants must have whole body imaging within 60 days prior to registration. The recommended method of imaging is a positron emission tomography/computed tomography (PET/CT); a low-dose whole body CT scan or whole-body magnetic resonance imaging (MRI) or skeletal survey should be done only if a PET/CT scan cannot be done or is non-feasible. This must be documented in the comments section of the Onstudy form. - Total bilirubin =< 2 times institutional upper limit of normal (ULN) unless history of Gilbert's disease. Participants with history of Gilbert's disease must have total bilirubin =< 5 x institutional ULN (within 28 days prior to registration) - Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) =< 3 × institutional ULN (within 28 days prior to registration) - Participants must have adequate cardiac function, as assessed by the treating physician within 14 days prior to registration. Participants with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, must have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification and must not be assessed as class 3 or 4 - Participants with known diabetes must show evidence of controlled disease within 14 days prior to registration. Uncontrolled diabetes is defined as: A glycosylated hemoglobin (Hg)A1C > 7 - Participants with known human immunodeficiency virus (HIV)-infection must be receiving anti-retroviral therapy and have an undetectable viral load test on the most recent test result obtained, within 6 months prior to registration - All participants with evidence of chronic hepatitis B virus (HBV) infection must have undetectable HBV viral load on suppressive therapy within 28 days prior to registration - Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment, participant must have an undetectable HCV viral load within 28 days prior to registration - Participants must have an Eastern Cooperative Oncology Group (ECOG)/Zubrod performance status score of 0-2 (Note: Participants with ECOG/Zubrod performance score [PS] 3, especially where the deterioration of PS is considered secondary to the MM diagnosis, will be allowed) - Participants must be offered the opportunity to participate in specimen banking. With participant consent, specimens must be collected and submitted via the Southwest Oncology Group (SWOG) specimen tracking system - Participants who are able to complete the patient-reported outcomes measures in English or Spanish must agree to participate in the PRO portion of the study - Participants must be informed of the investigational nature of this study and must sign and give informed consent in accordance with institutional and federal guidelines. For participants with impaired decision-making capabilities, legally authorized representatives may sign and give informed consent on behalf of study participants in accordance with applicable federal, local, and Central Institutional Review Board (CIRB) regulations
Exclusion Criteria
- Participants must not have received any prior systemic therapy for multiple myeloma with the exception of any one or more of the following: - An emergency use of a short course of corticosteroids (equivalent of dexamethasone 160 mg) any time before registration, or - Up to one complete cycle of a non-daratumumab and hyaluronidase-fihj containing anti-myeloma regimen (1 cycle = 21 or 28 days depending on the regimen being used), or - Localized palliative radiation therapy for multiple myeloma, as long as the radiation therapy is completed at least 3 days prior to starting the systemic treatment as per the study protocol. - Participants must not have evidence of grade 4 peripheral neuropathy prior to study registration - Participants must not have uncontrolled blood pressure within 14 days prior to registration. Uncontrolled blood pressure: systolic blood pressure (SBP) > 140 mmHg or diastolic blood pressure (DBP) > 90 mmHg. Participants are permitted to be receiving multiple anti-hypertensive medications (unless otherwise indicated in the study). All blood pressure measurements within the 14 days prior to registration must be SBP =< 140 and DBP =< 90. A participant with a single blood pressure elevation who upon rechecking has a normal blood pressure will remain eligible at the discretion of the registering investigator. - Participants must not have a prior or concurrent malignancy whose natural history or treatment (in the opinion of the treating physician) has the potential to interfere with the safety or efficacy assessment of the investigational regimen. - Participants must not be pregnant or nursing. Individuals who are of reproductive potential must have agreed to use an effective contraceptive method with details provided as a part of the consent process. A person who has had menses at any time in the preceding 24 consecutive months or who has semen likely to contain sperm is considered to be of "reproductive potential." In addition to routine contraceptive methods, "effective contraception" also includes refraining from sexual activity that might result in pregnancy and surgery intended to prevent pregnancy (or with a side-effect of pregnancy prevention) including hysterectomy, bilateral oophorectomy, bilateral tubal ligation/occlusion, and vasectomy with testing showing no sperm in the semen.
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Arm I (VRd-Lite) |
INDUCTION CYCLES 1-9: Patients receive bortezomib SC on days 1, 8, 15, and 22 of each cycle, lenalidomide PO on days 1-21 of each cycle, and dexamethasone PO on days 1, 8, 15, and 22 of each cycle. Treatment repeats every 28 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE CYCLES 10+: Patients receive lenalidomide PO on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. |
|
|
Experimental Arm II (DRd-R) |
INDUCTION CYCLES 1-9: Patients receive daratumumab and hyaluronidase-fihj SC on days 1, 8, 15, and 22 of cycles 1-2, days 1 and 15 of cycles 3-6, and day 1 of cycles 7-9, lenalidomide PO on days 1-21 of each cycle, and dexamethasone PO on days 1, 8, 15, and 22 of each cycle. Treatment repeats every 28 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE CYCLES 10+: Patients receive lenalidomide PO on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. |
|
|
Experimental Arm III (DRd-DR): |
INDUCTION CYCLES 1-9: Patients receive daratumumab and hyaluronidase-fihj SC on days 1, 8, 15, and 22 of cycles 1-2, days 1 and 15 of cycles 3-6, and day 1 of cycles 7-9, lenalidomide PO on days 1-21 of each cycle, and dexamethasone PO on days 1, 8, 15, and 22 of each cycle. Treatment repeats every 28 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE CYCLES 10+: Patients receive daratumumab and hyaluronidase-fihj SC on day 1 of each cycle and lenalidomide PO on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. |
|
Recruiting Locations
Anchorage Associates in Radiation Medicine
Anchorage 5879400, Alaska 5879092 98508
Anchorage 5879400, Alaska 5879092 98508
Anchorage Radiation Therapy Center
Anchorage 5879400, Alaska 5879092 99504
Anchorage 5879400, Alaska 5879092 99504
Alaska Breast Care and Surgery LLC
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Alaska Oncology and Hematology LLC
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Alaska Women's Cancer Care
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Anchorage Oncology Centre
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Katmai Oncology Group
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Providence Alaska Medical Center
Anchorage 5879400, Alaska 5879092 99508
Anchorage 5879400, Alaska 5879092 99508
Cancer Center at Saint Joseph's
Phoenix 5308655, Arizona 5551752 85004
Phoenix 5308655, Arizona 5551752 85004
Mercy Hospital Fort Smith
Fort Smith 4111410, Arkansas 4099753 72903
Fort Smith 4111410, Arkansas 4099753 72903
Contact:
Site Public Contact
800-378-9373
Site Public Contact
800-378-9373
CARTI Cancer Center
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
Mission Hope Medical Oncology - Arroyo Grande
Arroyo Grande 5324802, California 5332921 93420
Arroyo Grande 5324802, California 5332921 93420
Providence Saint Joseph Medical Center/Disney Family Cancer Center
Burbank 5331835, California 5332921 91505
Burbank 5331835, California 5332921 91505
Marshall Cancer Center
Cameron Park 5333282, California 5332921 95682
Cameron Park 5333282, California 5332921 95682
Mercy Cancer Center - Carmichael
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy San Juan Medical Center
Carmichael 5334336, California 5332921 95608
Carmichael 5334336, California 5332921 95608
Mercy Cancer Center - Elk Grove
Elk Grove 5346111, California 5332921 95758
Elk Grove 5346111, California 5332921 95758
Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Mercy UC Davis Cancer Center
Merced 5372253, California 5332921 95340
Merced 5372253, California 5332921 95340
Providence Queen of The Valley
Napa 5376095, California 5332921 94558
Napa 5376095, California 5332921 94558
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
Mercy Cancer Center - Rocklin
Rocklin 5388319, California 5332921 95765
Rocklin 5388319, California 5332921 95765
Mercy Cancer Center - Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
University of California Davis Comprehensive Cancer Center
Sacramento 5389489, California 5332921 95817
Sacramento 5389489, California 5332921 95817
Contact:
Site Public Contact
916-734-3089
Site Public Contact
916-734-3089
Pacific Central Coast Health Center-San Luis Obispo
San Luis Obispo 5392323, California 5332921 93401
San Luis Obispo 5392323, California 5332921 93401
Mission Hope Medical Oncology - Santa Maria
Santa Maria 5393180, California 5332921 93444
Santa Maria 5393180, California 5332921 93444
Providence Medical Foundation - Santa Rosa
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
Providence Santa Rosa Memorial Hospital
Santa Rosa 5393287, California 5332921 95405
Santa Rosa 5393287, California 5332921 95405
Contact:
Site Public Contact
707-521-3830
Site Public Contact
707-521-3830
Gene Upshaw Memorial Tahoe Forest Cancer Center
Truckee 5403676, California 5332921 96161
Truckee 5403676, California 5332921 96161
Contact:
Site Public Contact
530-582-6450
Site Public Contact
530-582-6450
Woodland Memorial Hospital
Woodland 5410430, California 5332921 95695
Woodland 5410430, California 5332921 95695
Rocky Mountain Regional VA Medical Center
Aurora 5412347, Colorado 5417618 80045
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
888-336-8262
Site Public Contact
888-336-8262
Penrose-Saint Francis Healthcare
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80907
Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80907
Saint Francis Cancer Center
Colorado Springs 5417598, Colorado 5417618 80923
Colorado Springs 5417598, Colorado 5417618 80923
Mercy Medical Center
Durango 5420241, Colorado 5417618 81301
Durango 5420241, Colorado 5417618 81301
Southwest Oncology PC
Durango 5420241, Colorado 5417618 81301
Durango 5420241, Colorado 5417618 81301
Saint Anthony Hospital
Lakewood 5427946, Colorado 5417618 80228
Lakewood 5427946, Colorado 5417618 80228
Longmont United Hospital
Longmont 5579276, Colorado 5417618 80501
Longmont 5579276, Colorado 5417618 80501
Saint Mary Corwin Medical Center
Pueblo 5435464, Colorado 5417618 81004
Pueblo 5435464, Colorado 5417618 81004
Smilow Cancer Hospital-Derby Care Center
Derby 4832745, Connecticut 4831725 06418
Derby 4832745, Connecticut 4831725 06418
Smilow Cancer Hospital Care Center-Fairfield
Fairfield 4834157, Connecticut 4831725 06824
Fairfield 4834157, Connecticut 4831725 06824
Smilow Cancer Hospital Care Center at Glastonbury
Glastonbury 4835003, Connecticut 4831725 06033
Glastonbury 4835003, Connecticut 4831725 06033
Smilow Cancer Hospital Care Center at Greenwich
Greenwich 4835395, Connecticut 4831725 06830
Greenwich 4835395, Connecticut 4831725 06830
Smilow Cancer Hospital Care Center - Guilford
Guilford 4835512, Connecticut 4831725 06437
Guilford 4835512, Connecticut 4831725 06437
Smilow Cancer Hospital Care Center at Saint Francis
Hartford 4835797, Connecticut 4831725 06105
Hartford 4835797, Connecticut 4831725 06105
Smilow Cancer Center/Yale-New Haven Hospital
New Haven 4839366, Connecticut 4831725 06510
New Haven 4839366, Connecticut 4831725 06510
Yale University
New Haven 4839366, Connecticut 4831725 06520
New Haven 4839366, Connecticut 4831725 06520
Yale-New Haven Hospital North Haven Medical Center
North Haven 4839704, Connecticut 4831725 06473
North Haven 4839704, Connecticut 4831725 06473
Smilow Cancer Hospital Care Center at Long Ridge
Stamford 4843564, Connecticut 4831725 06902
Stamford 4843564, Connecticut 4831725 06902
Smilow Cancer Hospital-Torrington Care Center
Torrington 4844309, Connecticut 4831725 06790
Torrington 4844309, Connecticut 4831725 06790
Smilow Cancer Hospital Care Center-Trumbull
Trumbull 4844459, Connecticut 4831725 06611
Trumbull 4844459, Connecticut 4831725 06611
Smilow Cancer Hospital-Waterbury Care Center
Waterbury 4845193, Connecticut 4831725 06708
Waterbury 4845193, Connecticut 4831725 06708
Smilow Cancer Hospital Care Center - Waterford
Waterford 8480031, Connecticut 4831725 06385
Waterford 8480031, Connecticut 4831725 06385
Holy Cross Hospital
Fort Lauderdale 4155966, Florida 4155751 33308
Fort Lauderdale 4155966, Florida 4155751 33308
Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751 32224-9980
Jacksonville 4160021, Florida 4155751 32224-9980
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Jupiter Medical Center
Jupiter 4160610, Florida 4155751 33458
Jupiter 4160610, Florida 4155751 33458
Contact:
Site Public Contact
561-745-5768
Site Public Contact
561-745-5768
Saint Luke's Cancer Institute - Boise
Boise 5586437, Idaho 5596512 83712
Boise 5586437, Idaho 5596512 83712
Saint Luke's Cancer Institute - Fruitland
Fruitland 5593708, Idaho 5596512 83619
Fruitland 5593708, Idaho 5596512 83619
Saint Luke's Cancer Institute - Meridian
Meridian 5600685, Idaho 5596512 83642
Meridian 5600685, Idaho 5596512 83642
Saint Luke's Cancer Institute - Nampa
Nampa 5601933, Idaho 5596512 83686
Nampa 5601933, Idaho 5596512 83686
Saint Luke's Cancer Institute - Twin Falls
Twin Falls 5610810, Idaho 5596512 83301
Twin Falls 5610810, Idaho 5596512 83301
Saint Anthony's Health
Alton 4232679, Illinois 4896861 62002
Alton 4232679, Illinois 4896861 62002
Contact:
Site Public Contact
618-463-5623
Site Public Contact
618-463-5623
Rush - Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Aurora 4883817, Illinois 4896861 60504
Saint Joseph Medical Center
Bloomington 4885164, Illinois 4896861 61701
Bloomington 4885164, Illinois 4896861 61701
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Loyola Center for Health at Burr Ridge
Burr Ridge 4886090, Illinois 4896861 60527
Burr Ridge 4886090, Illinois 4896861 60527
Contact:
Site Public Contact
708-216-9000
Site Public Contact
708-216-9000
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
Memorial Hospital of Carbondale
Carbondale 4235193, Illinois 4896861 62902
Carbondale 4235193, Illinois 4896861 62902
SIH Cancer Institute
Carterville 4235311, Illinois 4896861 62918
Carterville 4235311, Illinois 4896861 62918
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Saint Mary's Hospital
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Danville 4889426, Illinois 4896861 61832
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Illinois CancerCare-Dixon
Dixon 4889959, Illinois 4896861 61021
Dixon 4889959, Illinois 4896861 61021
Contact:
Site Public Contact
815-285-7800
Site Public Contact
815-285-7800
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Western Illinois Cancer Treatment Center
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Contact:
Site Public Contact
309-344-2831
Site Public Contact
309-344-2831
Edward Hines Jr VA Hospital
Hines 4896005, Illinois 4896861 60141
Hines 4896005, Illinois 4896861 60141
Contact:
Site Public Contact
708-202-8387
Site Public Contact
708-202-8387
Loyola Medicine Homer Glen
Homer Glen 4896336, Illinois 4896861 60491
Homer Glen 4896336, Illinois 4896861 60491
Contact:
Site Public Contact
708-216-9000
Site Public Contact
708-216-9000
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Mattoon 4244099, Illinois 4896861 61938
Loyola University Medical Center
Maywood 4901514, Illinois 4896861 60153
Maywood 4901514, Illinois 4896861 60153
Contact:
Site Public Contact
708-226-4357
Site Public Contact
708-226-4357
Marjorie Weinberg Cancer Center at Loyola-Gottlieb
Melrose Park 4901868, Illinois 4896861 60160
Melrose Park 4901868, Illinois 4896861 60160
Contact:
Site Public Contact
708-450-4554
Site Public Contact
708-450-4554
Good Samaritan Regional Health Center
Mount Vernon 4245152, Illinois 4896861 62864
Mount Vernon 4245152, Illinois 4896861 62864
Contact:
Site Public Contact
618-242-4600
Site Public Contact
618-242-4600
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Peoria 4905687, Illinois 4896861 61636
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Valley Radiation Oncology
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Contact:
Site Public Contact
815-664-4141
Site Public Contact
815-664-4141
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Memorial Medical Center
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
The Carle Foundation Hospital
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
Rush-Copley Healthcare Center
Yorkville 4917298, Illinois 4896861 60560
Yorkville 4917298, Illinois 4896861 60560
IU Health North Hospital
Carmel 4255466, Indiana 4921868 46032
Carmel 4255466, Indiana 4921868 46032
Northwest Cancer Center - Main Campus
Crown Point 4919451, Indiana 4921868 46307
Crown Point 4919451, Indiana 4921868 46307
Contact:
Site Public Contact
219-310-2550
Site Public Contact
219-310-2550
Northwest Oncology LLC
Dyer 4919820, Indiana 4921868 46311
Dyer 4919820, Indiana 4921868 46311
Contact:
Site Public Contact
219-924-8178
Site Public Contact
219-924-8178
Northwest Cancer Center - Hobart
Hobart 4921476, Indiana 4921868 46342
Hobart 4921476, Indiana 4921868 46342
Contact:
Site Public Contact
219-947-1795
Site Public Contact
219-947-1795
Saint Mary Medical Center
Hobart 4921476, Indiana 4921868 46342
Hobart 4921476, Indiana 4921868 46342
Indiana University/Melvin and Bren Simon Cancer Center
Indianapolis 4259418, Indiana 4921868 46202
Indianapolis 4259418, Indiana 4921868 46202
Saint Catherine Hospital
Indianapolis 4259418, Indiana 4921868 46312
Indianapolis 4259418, Indiana 4921868 46312
The Community Hospital
Munster 4924014, Indiana 4921868 46321
Munster 4924014, Indiana 4921868 46321
Contact:
Site Public Contact
219-836-3349
Site Public Contact
219-836-3349
Women's Diagnostic Center - Munster
Munster 4924014, Indiana 4921868 46321
Munster 4924014, Indiana 4921868 46321
Reid Health
Richmond 4263681, Indiana 4921868 47374
Richmond 4263681, Indiana 4921868 47374
Northwest Cancer Center - Valparaiso
Valparaiso 4927537, Indiana 4921868 46383
Valparaiso 4927537, Indiana 4921868 46383
Mission Cancer and Blood - Ankeny
Ankeny 4846960, Iowa 4862182 50023
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-282-2921
Site Public Contact
515-282-2921
University of Iowa Healthcare Cancer Services Quad Cities
Bettendorf 4848489, Iowa 4862182 52722
Bettendorf 4848489, Iowa 4862182 52722
Physicians' Clinic of Iowa PC
Cedar Rapids 4850751, Iowa 4862182 52402
Cedar Rapids 4850751, Iowa 4862182 52402
Contact:
Site Public Contact
319-297-2900
Site Public Contact
319-297-2900
Medical Oncology and Hematology Associates-West Des Moines
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Mercy Cancer Center-West Lakes
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Greater Regional Medical Center
Creston 4853078, Iowa 4862182 50801
Creston 4853078, Iowa 4862182 50801
Mercy Medical Center - Des Moines
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Mission Cancer and Blood - Laurel
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
University of Iowa/Holden Comprehensive Cancer Center
Iowa City 4862034, Iowa 4862182 52242
Iowa City 4862034, Iowa 4862182 52242
Contact:
Site Public Contact
800-237-1225
Site Public Contact
800-237-1225
Mercy Medical Center-West Lakes
West Des Moines 4881346, Iowa 4862182 50266
West Des Moines 4881346, Iowa 4862182 50266
Central Care Cancer Center - Garden City
Garden City 5445439, Kansas 4273857 67846
Garden City 5445439, Kansas 4273857 67846
Central Care Cancer Center - Great Bend
Great Bend 4272340, Kansas 4273857 67530
Great Bend 4272340, Kansas 4273857 67530
Flaget Memorial Hospital
Bardstown 4283133, Kentucky 6254925 40004
Bardstown 4283133, Kentucky 6254925 40004
Commonwealth Cancer Center-Corbin
Corbin 4288656, Kentucky 6254925 40701
Corbin 4288656, Kentucky 6254925 40701
Saint Joseph Hospital
Lexington 4297983, Kentucky 6254925 40504
Lexington 4297983, Kentucky 6254925 40504
Saint Joseph Radiation Oncology Resource Center
Lexington 4297983, Kentucky 6254925 40504
Lexington 4297983, Kentucky 6254925 40504
Saint Joseph Hospital East
Lexington 4297983, Kentucky 6254925 40509
Lexington 4297983, Kentucky 6254925 40509
Saint Joseph London
London 4298960, Kentucky 6254925 40741
London 4298960, Kentucky 6254925 40741
Saint Joseph Mount Sterling
Mount Sterling 4301683, Kentucky 6254925 40353
Mount Sterling 4301683, Kentucky 6254925 40353
Greater Baltimore Medical Center
Baltimore 4347778, Maryland 4361885 21204
Baltimore 4347778, Maryland 4361885 21204
Contact:
Site Public Contact
443-849-3706
Site Public Contact
443-849-3706
Saint Joseph Mercy Hospital
Ann Arbor 4984247, Michigan 5001836 48106
Ann Arbor 4984247, Michigan 5001836 48106
Bronson Battle Creek
Battle Creek 4985153, Michigan 5001836 49017
Battle Creek 4985153, Michigan 5001836 49017
Saint Joseph Mercy Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Saint Joseph Mercy Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Trinity Health IHA Medical Group Hematology Oncology - Canton
Canton 4987990, Michigan 5001836 48188
Canton 4987990, Michigan 5001836 48188
Caro Cancer Center
Caro 4988059, Michigan 5001836 48723
Caro 4988059, Michigan 5001836 48723
Saint Joseph Mercy Chelsea
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Hematology Oncology Consultants-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
Newland Medical Associates-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
Ascension Saint John Hospital
Detroit 4990729, Michigan 5001836 48236
Detroit 4990729, Michigan 5001836 48236
Great Lakes Cancer Management Specialists-Doctors Park
East China Township, Michigan 5001836 48054
East China Township, Michigan 5001836 48054
Genesee Cancer and Blood Disease Treatment Center
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Genesee Hematology Oncology PC
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Genesys Hurley Cancer Institute
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Hurley Medical Center
Flint 4992982, Michigan 5001836 48503
Flint 4992982, Michigan 5001836 48503
Helen DeVos Children's Hospital at Spectrum Health
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Spectrum Health at Butterworth Campus
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Academic Hematology Oncology Specialists
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Great Lakes Cancer Management Specialists-Van Elslander Cancer Center
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Grosse Pointe Woods 4994871, Michigan 5001836 48236
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
Ascension Borgess Cancer Center
Kalamazoo 4997787, Michigan 5001836 49009
Kalamazoo 4997787, Michigan 5001836 49009
Borgess Medical Center
Kalamazoo 4997787, Michigan 5001836 49048
Kalamazoo 4997787, Michigan 5001836 49048
University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Lansing 4998830, Michigan 5001836 48912
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Livonia 4999837, Michigan 5001836 48154
Great Lakes Cancer Management Specialists-Macomb Medical Campus
Macomb 5000473, Michigan 5001836 48044
Macomb 5000473, Michigan 5001836 48044
Saint Mary's Oncology/Hematology Associates of Marlette
Marlette 5000938, Michigan 5001836 48453
Marlette 5000938, Michigan 5001836 48453
Trinity Health Muskegon Hospital
Muskegon 5003132, Michigan 5001836 49444
Muskegon 5003132, Michigan 5001836 49444
Corewell Health Lakeland Hospitals - Niles Hospital
Niles 5003514, Michigan 5001836 49120
Niles 5003514, Michigan 5001836 49120
Contact:
Site Public Contact
616-391-1230
Site Public Contact
616-391-1230
Cancer and Hematology Centers of Western Michigan - Norton Shores
Norton Shores 5004005, Michigan 5001836 49444
Norton Shores 5004005, Michigan 5001836 49444
21st Century Oncology-Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Hope Cancer Center
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Newland Medical Associates-Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Saint Joseph Mercy Oakland
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Corewell Health Reed City Hospital
Reed City 5006946, Michigan 5001836 49677
Reed City 5006946, Michigan 5001836 49677
Ascension Saint Mary's Hospital
Saginaw 5007989, Michigan 5001836 48601
Saginaw 5007989, Michigan 5001836 48601
Oncology Hematology Associates of Saginaw Valley PC
Saginaw 5007989, Michigan 5001836 48604
Saginaw 5007989, Michigan 5001836 48604
Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Lakeland Medical Center Saint Joseph
Saint Joseph 5008327, Michigan 5001836 49085
Saint Joseph 5008327, Michigan 5001836 49085
Bhadresh Nayak MD PC-Sterling Heights
Sterling Heights 5011148, Michigan 5001836 48312
Sterling Heights 5011148, Michigan 5001836 48312
Ascension Saint Joseph Hospital
Tawas City 5011900, Michigan 5001836 48764
Tawas City 5011900, Michigan 5001836 48764
Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Traverse City 5012495, Michigan 5001836 49684
Advanced Breast Care Center PLLC
Warren 5014051, Michigan 5001836 48088
Warren 5014051, Michigan 5001836 48088
Great Lakes Cancer Management Specialists-Macomb Professional Building
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
Macomb Hematology Oncology PC
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
Michigan Breast Specialists-Warren
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
Saint John Macomb-Oakland Hospital
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
Saint Mary's Oncology/Hematology Associates of West Branch
West Branch 5014413, Michigan 5001836 48661
West Branch 5014413, Michigan 5001836 48661
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Wyoming 5015618, Michigan 5001836 49519
Huron Gastroenterology PC
Ypsilanti 5015688, Michigan 5001836 48106
Ypsilanti 5015688, Michigan 5001836 48106
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Ypsilanti 5015688, Michigan 5001836 48197
Riverwood Healthcare Center
Aitkin 5015978, Minnesota 5037779 56431
Aitkin 5015978, Minnesota 5037779 56431
Essentia Health - Baxter Clinic
Baxter 5017396, Minnesota 5037779 56425
Baxter 5017396, Minnesota 5037779 56425
Contact:
Site Public Contact
218-828-2880
Site Public Contact
218-828-2880
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Essentia Health Saint Joseph's Medical Center
Brainerd 5019116, Minnesota 5037779 56401
Brainerd 5019116, Minnesota 5037779 56401
Minnesota Oncology - Burnsville
Burnsville 5019767, Minnesota 5037779 55337
Burnsville 5019767, Minnesota 5037779 55337
Cambridge Medical Center
Cambridge 5020068, Minnesota 5037779 55008
Cambridge 5020068, Minnesota 5037779 55008
Mercy Hospital
Coon Rapids 5022025, Minnesota 5037779 55433
Coon Rapids 5022025, Minnesota 5037779 55433
Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779 56636
Deer River 5024099, Minnesota 5037779 56636
Essentia Health Saint Mary's - Detroit Lakes Clinic
Detroit Lakes 5024237, Minnesota 5037779 56501
Detroit Lakes 5024237, Minnesota 5037779 56501
Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Essentia Health Saint Mary's Medical Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Fairview Southdale Hospital
Edina 5025264, Minnesota 5037779 55435
Edina 5025264, Minnesota 5037779 55435
Essentia Health - Ely Clinic
Ely 5025627, Minnesota 5037779 55731
Ely 5025627, Minnesota 5037779 55731
Contact:
Site Public Contact
218-365-7900
Site Public Contact
218-365-7900
Essentia Health - Fosston
Fosston 5027191, Minnesota 5037779 56542
Fosston 5027191, Minnesota 5037779 56542
Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779 55746
Hibbing 5030005, Minnesota 5037779 55746
Contact:
Site Public Contact
218-786-3308
Site Public Contact
218-786-3308
Essentia Health - International Falls Clinic
International Falls 5031404, Minnesota 5037779 56649
International Falls 5031404, Minnesota 5037779 56649
Contact:
Site Public Contact
218-283-9431
Site Public Contact
218-283-9431
Fairview Clinics and Surgery Center Maple Grove
Maple Grove 5036493, Minnesota 5037779 55369
Maple Grove 5036493, Minnesota 5037779 55369
Minnesota Oncology Hematology PA-Maplewood
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Saint John's Hospital - Healtheast
Maplewood 5036588, Minnesota 5037779 55109
Maplewood 5036588, Minnesota 5037779 55109
Abbott-Northwestern Hospital
Minneapolis 5037649, Minnesota 5037779 55407
Minneapolis 5037649, Minnesota 5037779 55407
Hennepin County Medical Center
Minneapolis 5037649, Minnesota 5037779 55415
Minneapolis 5037649, Minnesota 5037779 55415
Health Partners Inc
Minneapolis 5037649, Minnesota 5037779 55454
Minneapolis 5037649, Minnesota 5037779 55454
Monticello Cancer Center
Monticello 5038045, Minnesota 5037779 55362
Monticello 5038045, Minnesota 5037779 55362
Essentia Health - Moose Lake Clinic
Moose Lake 5038132, Minnesota 5037779 55767
Moose Lake 5038132, Minnesota 5037779 55767
Contact:
Site Public Contact
218-485-4481
Site Public Contact
218-485-4481
New Ulm Medical Center
New Ulm 5039173, Minnesota 5037779 56073
New Ulm 5039173, Minnesota 5037779 56073
Essentia Health - Park Rapids
Park Rapids 5040822, Minnesota 5037779 56470
Park Rapids 5040822, Minnesota 5037779 56470
Fairview Northland Medical Center
Princeton 5042360, Minnesota 5037779 55371
Princeton 5042360, Minnesota 5037779 55371
North Memorial Medical Health Center
Robbinsdale 5043439, Minnesota 5037779 55422
Robbinsdale 5043439, Minnesota 5037779 55422
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park 5045021, Minnesota 5037779 55416
Saint Louis Park 5045021, Minnesota 5037779 55416
Regions Hospital
Saint Paul 5045360, Minnesota 5037779 55101
Saint Paul 5045360, Minnesota 5037779 55101
United Hospital
Saint Paul 5045360, Minnesota 5037779 55102
Saint Paul 5045360, Minnesota 5037779 55102
Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779 55072
Sandstone 5045908, Minnesota 5037779 55072
Saint Francis Regional Medical Center
Shakopee 5046997, Minnesota 5037779 55379
Shakopee 5046997, Minnesota 5037779 55379
Lakeview Hospital
Stillwater 5048814, Minnesota 5037779 55082
Stillwater 5048814, Minnesota 5037779 55082
Sanford Thief River Falls Medical Center
Thief River Falls 5049970, Minnesota 5037779 56701
Thief River Falls 5049970, Minnesota 5037779 56701
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779 55792
Virginia 5051468, Minnesota 5037779 55792
Ridgeview Medical Center
Waconia 5051640, Minnesota 5037779 55387
Waconia 5051640, Minnesota 5037779 55387
Rice Memorial Hospital
Willmar 5052916, Minnesota 5037779 56201
Willmar 5052916, Minnesota 5037779 56201
Minnesota Oncology Hematology PA-Woodbury
Woodbury 5053358, Minnesota 5037779 55125
Woodbury 5053358, Minnesota 5037779 55125
Sanford Cancer Center Worthington
Worthington 5053460, Minnesota 5037779 56187
Worthington 5053460, Minnesota 5037779 56187
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Fairview Lakes Medical Center
Wyoming 5053526, Minnesota 5037779 55092
Wyoming 5053526, Minnesota 5037779 55092
Saint Louis Cancer and Breast Institute-Ballwin
Ballwin 4375663, Missouri 4398678 63011
Ballwin 4375663, Missouri 4398678 63011
Contact:
Site Public Contact
314-251-7058
Site Public Contact
314-251-7058
Central Care Cancer Center - Bolivar
Bolivar 4377835, Missouri 4398678 65613
Bolivar 4377835, Missouri 4398678 65613
Cox Cancer Center Branson
Branson 4378219, Missouri 4398678 65616
Branson 4378219, Missouri 4398678 65616
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Southeast Cancer Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Contact:
Site Public Contact
573-651-5550
Site Public Contact
573-651-5550
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Capital Region Southwest Campus
Jefferson City 4392388, Missouri 4398678 65109
Jefferson City 4392388, Missouri 4398678 65109
Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Joplin 4392768, Missouri 4398678 64804
Mercy Hospital Joplin
Joplin 4392768, Missouri 4398678 64804
Joplin 4392768, Missouri 4398678 64804
Research Medical Center
Kansas City 4393217, Missouri 4398678 64132
Kansas City 4393217, Missouri 4398678 64132
Lake Regional Hospital
Osage Beach 4402040, Missouri 4398678 65065
Osage Beach 4402040, Missouri 4398678 65065
Delbert Day Cancer Institute at PCRMC
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Mercy Clinic-Rolla-Cancer and Hematology
Rolla 4406282, Missouri 4398678 65401
Rolla 4406282, Missouri 4398678 65401
Contact:
Site Public Contact
573-458-6379
Site Public Contact
573-458-6379
Heartland Regional Medical Center
Saint Joseph 4407010, Missouri 4398678 64506
Saint Joseph 4407010, Missouri 4398678 64506
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
CoxHealth South Hospital
Springfield 4409896, Missouri 4398678 65807
Springfield 4409896, Missouri 4398678 65807
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Saint Louis Cancer and Breast Institute-South City
St Louis 4407066, Missouri 4398678 63109
St Louis 4407066, Missouri 4398678 63109
Contact:
Site Public Contact
314-353-1870
Site Public Contact
314-353-1870
Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
St Louis 4407066, Missouri 4398678 63128
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Washington
Washington 4413621, Missouri 4398678 63090
Washington 4413621, Missouri 4398678 63090
Contact:
Site Public Contact
636-390-1600
Site Public Contact
636-390-1600
Saint Patrick Hospital - Community Hospital
Missoula 5666639, Montana 5667009 59802
Missoula 5666639, Montana 5667009 59802
CHI Health Good Samaritan
Kearney 5071348, Nebraska 5073708 68847
Kearney 5071348, Nebraska 5073708 68847
Alegent Health Immanuel Medical Center
Omaha 5074472, Nebraska 5073708 68122
Omaha 5074472, Nebraska 5073708 68122
Alegent Health Bergan Mercy Medical Center
Omaha 5074472, Nebraska 5073708 68124
Omaha 5074472, Nebraska 5073708 68124
Alegent Health Lakeside Hospital
Omaha 5074472, Nebraska 5073708 68130
Omaha 5074472, Nebraska 5073708 68130
Creighton University Medical Center
Omaha 5074472, Nebraska 5073708 68131
Omaha 5074472, Nebraska 5073708 68131
Exeter Hospital
Exeter 5085966, New Hampshire 5090174 03833
Exeter 5085966, New Hampshire 5090174 03833
Contact:
Site Public Contact
800-439-3837
Site Public Contact
800-439-3837
Lovelace Medical Center-Saint Joseph Square
Albuquerque 5454711, New Mexico 5481136 87102
Albuquerque 5454711, New Mexico 5481136 87102
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87102
Albuquerque 5454711, New Mexico 5481136 87102
Presbyterian Kaseman Hospital
Albuquerque 5454711, New Mexico 5481136 87110
Albuquerque 5454711, New Mexico 5481136 87110
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Rio Rancho 5487811, New Mexico 5481136 87124
NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York 5128581, New York 5128638 10032
New York 5128581, New York 5128638 10032
University of Rochester
Rochester 5134086, New York 5128638 14642
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Essentia Health Cancer Center-South University Clinic
Fargo 5059163, North Dakota 5690763 58103
Fargo 5059163, North Dakota 5690763 58103
Sanford South University Medical Center
Fargo 5059163, North Dakota 5690763 58103
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
701-234-6161
Site Public Contact
701-234-6161
Southpointe-Sanford Medical Center Fargo
Fargo 5059163, North Dakota 5690763 58103
Fargo 5059163, North Dakota 5690763 58103
Contact:
Site Public Contact
605-312-3320
Site Public Contact
605-312-3320
Sanford Medical Center Fargo
Fargo 5059163, North Dakota 5690763 58104
Fargo 5059163, North Dakota 5690763 58104
Contact:
Site Public Contact
800-437-4010
Site Public Contact
800-437-4010
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Essentia Health - Jamestown Clinic
Jamestown 5059836, North Dakota 5690763 58401
Jamestown 5059836, North Dakota 5690763 58401
Indu and Raj Soin Medical Center
Beavercreek 4506008, Ohio 5165418 45431
Beavercreek 4506008, Ohio 5165418 45431
Saint Elizabeth Boardman Hospital
Boardman 5147784, Ohio 5165418 44512
Boardman 5147784, Ohio 5165418 44512
Dayton Physicians LLC-Miami Valley South
Centerville 4508204, Ohio 5165418 45459
Centerville 4508204, Ohio 5165418 45459
Good Samaritan Hospital - Cincinnati
Cincinnati 4508722, Ohio 5165418 45220
Cincinnati 4508722, Ohio 5165418 45220
Oncology Hematology Care Inc-Kenwood
Cincinnati 4508722, Ohio 5165418 45236
Cincinnati 4508722, Ohio 5165418 45236
Bethesda North Hospital
Cincinnati 4508722, Ohio 5165418 45242
Cincinnati 4508722, Ohio 5165418 45242
TriHealth Cancer Institute-Westside
Cincinnati 4508722, Ohio 5165418 45247
Cincinnati 4508722, Ohio 5165418 45247
TriHealth Cancer Institute-Anderson
Cincinnati 4508722, Ohio 5165418 45255
Cincinnati 4508722, Ohio 5165418 45255
Dayton Physician LLC-Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Dayton 4509884, Ohio 5165418 45415
Armes Family Cancer Center
Findlay 5153924, Ohio 5165418 45840
Findlay 5153924, Ohio 5165418 45840
Blanchard Valley Hospital
Findlay 5153924, Ohio 5165418 45840
Findlay 5153924, Ohio 5165418 45840
Orion Cancer Care
Findlay 5153924, Ohio 5165418 45840
Findlay 5153924, Ohio 5165418 45840
Dayton Physicians LLC-Atrium
Franklin 4512203, Ohio 5165418 45005
Franklin 4512203, Ohio 5165418 45005
Dayton Physicians LLC-Wayne
Greenville 5156493, Ohio 5165418 45331
Greenville 5156493, Ohio 5165418 45331
Wayne Hospital
Greenville 5156493, Ohio 5165418 45331
Greenville 5156493, Ohio 5165418 45331
Greater Dayton Cancer Center
Kettering 4515843, Ohio 5165418 45409
Kettering 4515843, Ohio 5165418 45409
Kettering Medical Center
Kettering 4515843, Ohio 5165418 45429
Kettering 4515843, Ohio 5165418 45429
Dayton Physicians LLC - Troy
Troy 5174358, Ohio 5165418 45373
Troy 5174358, Ohio 5165418 45373
Saint Joseph Warren Hospital
Warren 5175865, Ohio 5165418 44484
Warren 5175865, Ohio 5165418 44484
Saint Elizabeth Youngstown Hospital
Youngstown 5177568, Ohio 5165418 44501
Youngstown 5177568, Ohio 5165418 44501
Mercy Hospital Oklahoma City
Oklahoma City 4544349, Oklahoma 4544379 73120
Oklahoma City 4544349, Oklahoma 4544379 73120
Contact:
Site Public Contact
405-752-3402
Site Public Contact
405-752-3402
Saint Charles Health System
Bend 5713587, Oregon 5744337 97701
Bend 5713587, Oregon 5744337 97701
Clackamas Radiation Oncology Center
Clackamas 5719308, Oregon 5744337 97015
Clackamas 5719308, Oregon 5744337 97015
Providence Cancer Institute Clackamas Clinic
Clackamas 5719308, Oregon 5744337 97015
Clackamas 5719308, Oregon 5744337 97015
Bay Area Hospital
Coos Bay 5720495, Oregon 5744337 97420
Coos Bay 5720495, Oregon 5744337 97420
Rogue Valley Medical Center
Medford 5740099, Oregon 5744337 97504
Medford 5740099, Oregon 5744337 97504
Providence Newberg Medical Center
Newberg 5742726, Oregon 5744337 97132
Newberg 5742726, Oregon 5744337 97132
Providence Willamette Falls Medical Center
Oregon City 5744253, Oregon 5744337 97045
Oregon City 5744253, Oregon 5744337 97045
Providence Portland Medical Center
Portland 5746545, Oregon 5744337 97213
Portland 5746545, Oregon 5744337 97213
Providence Saint Vincent Medical Center
Portland 5746545, Oregon 5744337 97225
Portland 5746545, Oregon 5744337 97225
Saint Charles Health System-Redmond
Redmond 5747882, Oregon 5744337 97756
Redmond 5747882, Oregon 5744337 97756
Contact:
Site Public Contact
541-706-2909
Site Public Contact
541-706-2909
Lehigh Valley Hospital-Cedar Crest
Allentown 5178127, Pennsylvania 6254927 18103
Allentown 5178127, Pennsylvania 6254927 18103
Lehigh Valley Hospital - Muhlenberg
Bethlehem 5180225, Pennsylvania 6254927 18017
Bethlehem 5180225, Pennsylvania 6254927 18017
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Danville 5186327, Pennsylvania 6254927 17822
Pocono Medical Center
East Stroudsburg 5188075, Pennsylvania 6254927 18301
East Stroudsburg 5188075, Pennsylvania 6254927 18301
Lehigh Valley Hospital-Hazleton
Hazleton 5193011, Pennsylvania 6254927 18201
Hazleton 5193011, Pennsylvania 6254927 18201
Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927 17837
Lewisburg 5197842, Pennsylvania 6254927 17837
Community Medical Center
Scranton 5211303, Pennsylvania 6254927 18510
Scranton 5211303, Pennsylvania 6254927 18510
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Smilow Cancer Hospital Care Center - Westerly
Westerly 5225631, Rhode Island 5224323 02891
Westerly 5225631, Rhode Island 5224323 02891
Prisma Health Cancer Institute - Spartanburg
Boiling Springs 4571805, South Carolina 4597040 29316
Boiling Springs 4571805, South Carolina 4597040 29316
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Easley
Easley 4577263, South Carolina 4597040 29640
Easley 4577263, South Carolina 4597040 29640
Prisma Health Cancer Institute - Butternut
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Faris
Greenville 4580543, South Carolina 4597040 29605
Greenville 4580543, South Carolina 4597040 29605
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Eastside
Greenville 4580543, South Carolina 4597040 29615
Greenville 4580543, South Carolina 4597040 29615
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Greer
Greer 4580599, South Carolina 4597040 29650
Greer 4580599, South Carolina 4597040 29650
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Prisma Health Cancer Institute - Seneca
Seneca 4595346, South Carolina 4597040 29672
Seneca 4595346, South Carolina 4597040 29672
Contact:
Site Public Contact
864-241-6251
Site Public Contact
864-241-6251
Avera Cancer Institute-Aberdeen
Aberdeen 5225857, South Dakota 5769223 57401
Aberdeen 5225857, South Dakota 5769223 57401
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Avera Cancer Institute
Sioux Falls 5231851, South Dakota 5769223 57105
Sioux Falls 5231851, South Dakota 5769223 57105
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Avera Cancer Institute at Yankton
Yankton 5233053, South Dakota 5769223 57078
Yankton 5233053, South Dakota 5769223 57078
MD Anderson in The Woodlands
Conroe 4682991, Texas 4736286 77384
Conroe 4682991, Texas 4736286 77384
Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Ben Taub General Hospital
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
713-873-2000
Site Public Contact
713-873-2000
M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Michael E DeBakey VA Medical Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
Contact:
Site Public Contact
800-553-2278
Site Public Contact
800-553-2278
MD Anderson West Houston
Houston 4699066, Texas 4736286 77079
Houston 4699066, Texas 4736286 77079
MD Anderson League City
League City 4705692, Texas 4736286 77573
League City 4705692, Texas 4736286 77573
University of Texas Health Science Center at San Antonio
San Antonio 4726206, Texas 4736286 78229
San Antonio 4726206, Texas 4736286 78229
MD Anderson in Sugar Land
Sugar Land 4734825, Texas 4736286 77478
Sugar Land 4734825, Texas 4736286 77478
Sovah Health Martinsville
Martinsville 4771808, Virginia 6254928 24115
Martinsville 4771808, Virginia 6254928 24115
Virginia Cancer Institute
Richmond 4781708, Virginia 6254928 23229
Richmond 4781708, Virginia 6254928 23229
VCU Massey Cancer Center at Stony Point
Richmond 4781708, Virginia 6254928 23235
Richmond 4781708, Virginia 6254928 23235
Virginia Commonwealth University/Massey Cancer Center
Richmond 4781708, Virginia 6254928 23298
Richmond 4781708, Virginia 6254928 23298
VCU Community Memorial Health Center
South Hill 4786619, Virginia 6254928 23970
South Hill 4786619, Virginia 6254928 23970
Providence Regional Cancer System-Aberdeen
Aberdeen 5785243, Washington 5815135 98520
Aberdeen 5785243, Washington 5815135 98520
PeaceHealth Saint Joseph Medical Center
Bellingham 5786899, Washington 5815135 98225
Bellingham 5786899, Washington 5815135 98225
Contact:
Site Public Contact
360-788-8223
Site Public Contact
360-788-8223
Harrison Medical Center
Bremerton 5788054, Washington 5815135 98310
Bremerton 5788054, Washington 5815135 98310
Providence Regional Cancer System-Centralia
Centralia 5789683, Washington 5815135 98531
Centralia 5789683, Washington 5815135 98531
Swedish Cancer Institute-Edmonds
Edmonds 5793427, Washington 5815135 98026
Edmonds 5793427, Washington 5815135 98026
Providence Regional Cancer Partnership
Everett 5793933, Washington 5815135 98201
Everett 5793933, Washington 5815135 98201
Swedish Cancer Institute-Issaquah
Issaquah 5798487, Washington 5815135 98029
Issaquah 5798487, Washington 5815135 98029
Kadlec Clinic Hematology and Oncology
Kennewick 5799610, Washington 5815135 99336
Kennewick 5799610, Washington 5815135 99336
Providence Regional Cancer System-Lacey
Lacey 5800112, Washington 5815135 98503
Lacey 5800112, Washington 5815135 98503
PeaceHealth Saint John Medical Center
Longview 5801617, Washington 5815135 98632
Longview 5801617, Washington 5815135 98632
Swedish Medical Center-Ballard Campus
Seattle 5809844, Washington 5815135 98107
Seattle 5809844, Washington 5815135 98107
Swedish Medical Center-Cherry Hill
Seattle 5809844, Washington 5815135 98122-5711
Seattle 5809844, Washington 5815135 98122-5711
Swedish Medical Center-First Hill
Seattle 5809844, Washington 5815135 98122
Seattle 5809844, Washington 5815135 98122
PeaceHealth United General Medical Center
Sedro-Woolley 5809902, Washington 5815135 98284
Sedro-Woolley 5809902, Washington 5815135 98284
Providence Regional Cancer System-Shelton
Shelton 5810176, Washington 5815135 98584
Shelton 5810176, Washington 5815135 98584
PeaceHealth Southwest Medical Center
Vancouver 5814616, Washington 5815135 98664
Vancouver 5814616, Washington 5815135 98664
Providence Saint Mary Regional Cancer Center
Walla Walla 5814916, Washington 5815135 99362
Walla Walla 5814916, Washington 5815135 99362
Providence Regional Cancer System-Yelm
Yelm 5816656, Washington 5815135 98597
Yelm 5816656, Washington 5815135 98597
West Virginia University Charleston Division
Charleston 4801859, West Virginia 4826850 25304
Charleston 4801859, West Virginia 4826850 25304
Contact:
Site Public Contact
304-388-9944
Site Public Contact
304-388-9944
Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Antigo 5244010, Wisconsin 5279468 54409
ThedaCare Regional Cancer Center
Appleton 5244080, Wisconsin 5279468 54911
Appleton 5244080, Wisconsin 5279468 54911
Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
Marshfield Clinic-Chippewa Center
Chippewa Falls 5248511, Wisconsin 5279468 54729
Chippewa Falls 5248511, Wisconsin 5279468 54729
Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Eau Claire 5251436, Wisconsin 5279468 54701
Essentia Health-Hayward Clinic
Hayward 5255882, Wisconsin 5279468 54843
Hayward 5255882, Wisconsin 5279468 54843
Gundersen Lutheran Medical Center
La Crosse 5258957, Wisconsin 5279468 54601
La Crosse 5258957, Wisconsin 5279468 54601
Marshfield Clinic - Ladysmith Center
Ladysmith 5259048, Wisconsin 5279468 54848
Ladysmith 5259048, Wisconsin 5279468 54848
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Marshfield 5261969, Wisconsin 5279468 54449
Aspirus Medford Hospital
Medford 5262475, Wisconsin 5279468 54451
Medford 5262475, Wisconsin 5279468 54451
Marshfield Clinic-Minocqua Center
Minocqua 5263156, Wisconsin 5279468 54548
Minocqua 5263156, Wisconsin 5279468 54548
Marshfield Medical Center - Neillsville
Neillsville 5264241, Wisconsin 5279468 54456
Neillsville 5264241, Wisconsin 5279468 54456
Cancer Center of Western Wisconsin
New Richmond 5264475, Wisconsin 5279468 54017
New Richmond 5264475, Wisconsin 5279468 54017
Ascension Saint Mary's Hospital
Rhinelander 5268720, Wisconsin 5279468 54501
Rhinelander 5268720, Wisconsin 5279468 54501
Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Rice Lake 5268798, Wisconsin 5279468 54868
Essentia Health-Spooner Clinic
Spooner 5274034, Wisconsin 5279468 54801
Spooner 5274034, Wisconsin 5279468 54801
Ascension Saint Michael's Hospital
Stevens Point 5274644, Wisconsin 5279468 54481
Stevens Point 5274644, Wisconsin 5279468 54481
Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Stevens Point 5274644, Wisconsin 5279468 54482
Essentia Health Saint Mary's Hospital - Superior
Superior 5275191, Wisconsin 5279468 54880
Superior 5275191, Wisconsin 5279468 54880
Contact:
Site Public Contact
701-364-6272
Site Public Contact
701-364-6272
Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Marshfield Clinic-Wausau Center
Wausau 5278120, Wisconsin 5279468 54401
Wausau 5278120, Wisconsin 5279468 54401
Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Weston 5278693, Wisconsin 5279468 54476
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
Marshfield Clinic - Wisconsin Rapids Center
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
More Details
- NCT ID
- NCT05561387
- Status
- Recruiting
- Sponsor
- SWOG Cancer Research Network
Detailed Description
PRIMARY OBJECTIVES: I. To compare progression-free survival (PFS) in frail or selected intermediate fit newly diagnosed multiple myeloma (NDMM) participants treated with bortezomib with lenalidomide and dexamethasone at reduced dosing (VRd-Lite) induction followed by lenalidomide maintenance (Arm 1) versus daratumumab and hyaluronidase-fihj with lenalidomide and dexamethasone (DRd) induction followed by lenalidomide maintenance (Arm 2). II. To compare overall survival (OS) in frail or selected intermediate fit NDMM participants treated with VRd-Lite induction followed by lenalidomide maintenance (Arm 1) versus DRd induction followed by lenalidomide and daratumumab and hyaluronidase-fihj maintenance (Arm 3). SECONDARY OBJECTIVES: I. To compare PFS in Arm 1 versus Arm 3 II. To compare OS in Arm 1 versus Arm 2. III. To compare PFS in Arm 2 versus 3. IV. To compare the overall response rate (ORR) of Arm 1 against the ORR of Arm 2 and Arm 3. V. To compare the safety of Arm 1 with the safety of Arm 2 and Arm 3. VI. To explore veinous thrombo-embolism (VTE) incidence in participants receiving lenalidomide during induction across the three study arms. VII. To describe median time to response (complete response [CR] or better per International Myeloma Working Group [IMWG] criteria, very good partial response [VGPR] or better per IMWG criteria, partial response [PR] or better per IMWG criteria) on the three study arms. PRIMARY QUALITY OF LIFE (QOL) OBJECTIVE: I. To compare patient-reported global health status between treatment arms (Arm 1 versus the combination of Arms 2 and 3) at 9 months after randomization (end of induction therapy) using the European Organization for Research and Treatment of Cancer (EORTC) Core Quality of Life Questionnaire (QLQ-C30). SECONDARY QOL OBJECTIVE: II. To compare longitudinal changes in global health status between treatment arms (Arm 1 versus the combination of Arms 2 and 3) from baseline to 9 months after randomization (end of induction therapy). PATIENT REPORTED OUTCOMES-COMMON TERMINOLOGY CRITERIA FOR ADVERSE EVENTS (PRO-CTCAE) OBJECTIVE: I. To compare selected patient-reported outcome symptoms using PRO-CTCAE items among the 3 study arms. ADDITIONAL OBJECTIVES: I. To compare the rate of minimal residual disease (MRD) by clonoSEQ after 9 cycles of induction in Arm 1 versus Arm 2 and Arm 3, respectively. II. To compare the rate of MRD conversion after 1 year of maintenance in participants who were MRD positive after induction in Arm 1 versus Arm 2 and Arm 3, respectively. III. To compare the rate of sustained MRD negativity at time points of post-induction, post-1 year maintenance in Arm 1 versus Arm 2 and Arm 3, respectively. BANKING OBJECTIVES: I. To bank specimens for future correlative studies. OUTLINE: Patients are randomized to 1 of 3 arms. ARM I (VRd-Lite): INDUCTION CYCLES 1-9: Patients receive bortezomib subcutaneously (SC) on days 1, 8, 15, and 22 of each cycle, lenalidomide orally (PO) on days 1-21 of each cycle, and dexamethasone PO on days 1, 8, 15, and 22 of each cycle. Treatment repeats every 28 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE CYCLES 10+: Patients receive lenalidomide PO on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. ARM II (DRd-R): INDUCTION CYCLES 1-9: Patients receive daratumumab and hyaluronidase-fihj SC on days 1, 8, 15, and 22 of cycles 1-2, days 1 and 15 of cycles 3-6, and day 1 of cycles 7-9, lenalidomide PO on days 1-21 of each cycle, and dexamethasone PO on days 1, 8, 15, and 22 of each cycle. Treatment repeats every 28 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE CYCLES 10+: Patients receive lenalidomide PO on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. ARM III (DRd-DR): INDUCTION CYCLES 1-9: Patients receive daratumumab and hyaluronidase-fihj SC on days 1, 8, 15, and 22 of cycles 1-2, days 1 and 15 of cycles 3-6, and day 1 of cycles 7-9, lenalidomide PO on days 1-21 of each cycle, and dexamethasone PO on days 1, 8, 15, and 22 of each cycle. Treatment repeats every 28 days for up to 9 cycles in the absence of disease progression or unacceptable toxicity. MAINTENANCE CYCLES 10+: Patients receive daratumumab and hyaluronidase-fihj SC on day 1 of each cycle and lenalidomide PO on days 1-21 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months for 1 year, every 6 months for 2 years, and then annually for up to 10 years.