Testing the Addition of High Dose, Targeted Radiation to the Usual Treatment for Locally-Advanced Inoperable Non-small Cell Lung Cancer
Purpose
This phase III trial compares the effect of adding stereotactic body radiation therapy (SBRT) to the usual treatment (conventional image guided radiation therapy [IGRT] and chemotherapy followed by immunotherapy with durvalumab or osimertinib) versus the usual treatment alone in treating patients with non-small cell lung cancer that has spread to nearby tissue or lymph nodes (locally advanced) and cannot be treated by surgery (inoperable). SBRT uses special equipment to position a patient and deliver radiation to tumors with high precision. This method may kill tumor cells with fewer doses over a shorter period and cause less damage to normal tissue. IGRT is a type of radiation that uses a computer to create a picture of the tumor, to help guide the radiation beam during therapy, making it more accurate and causing less damage to healthy tissue. Usual chemotherapy used in this trial consists of combinations of the following drugs: cisplatin, carboplatin, paclitaxel, nab-paclitaxel, pemetrexed, and etoposide. Cisplatin and carboplatin are in a class of medications known as platinum-containing compounds. Cisplatin works by killing, stopping, or slowing the growth of tumor cells. Carboplatin works in a way similar to the anticancer drug cisplatin but may be better tolerated than cisplatin. Carboplatin works by killing, stopping, or slowing the growth of tumor cells as well. Paclitaxel is in a class of medications called antimicrotubule agents. It works by stopping the growth and spread of tumor cells. Nab-paclitaxel is an albumin-stabilized nanoparticle formulation of paclitaxel which may have fewer side effects and work better than other forms of paclitaxel. Pemetrexed is in a class of medications called antifolate antineoplastic agents. It works by blocking the action of a certain substance in the body that may help tumor cells multiply. Etoposide is in a class of medications known as podophyllotoxin derivatives. It blocks a certain enzyme needed for cell division and deoxyribonucleic acid (DNA) repair and may kill tumor cells. Immunotherapy with durvalumab, may induce changes in the body's immune system and may interfere with the ability of tumor cells to grow and spread. Osimertinib is in a class of medications called kinase inhibitors. It works by blocking the action of a protein called EGFR that signals cancer cells to multiply. This helps slow or stop the spread of tumor cells. Adding SBRT to the usual treatment of IGRT with chemotherapy and immunotherapy may be more effective at treating patients with locally-advanced non-small cell lung cancer than giving the usual treatment alone.
Conditions
- Locally Advanced Lung Non-Small Cell Carcinoma
- Stage IIB Lung Cancer AJCC v8
- Stage III Lung Cancer AJCC v8
Eligibility
- Eligible Ages
- Over 18 Years
- Eligible Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- Pathologically (histologically or cytologically) proven diagnosis of non-operable stage IIB or III, node positive (American Joint Committee on Cancer [AJCC] eighth edition) non-small cell lung cancer (NSCLC) with known PD-L1 status prior to registration - Patients must have an identified primary tumor and at least one nodal metastasis (peribronchial/hilar/intrapulmonary, mediastinal/subcarinal, supraclavicular/scalene) - Up to 4 cycles of systemic therapy received prior to registration for the current study cancer is allowable; any prior chemotherapy for a different cancer is also permissible - Patients who refuse surgery, in addition to those who are technically unresectable or medically inoperable, are eligible. - Patients with separate tumor nodules in the same lobe of the primary tumor are eligible - The patient must be deemed clinically appropriate for curative intent definitive combined modality therapy, based on the following staging assessments: - History/physical examination prior to registration; - Magnetic resonance imaging (MRI) scan of the brain (preferred) or CT scan of the brain (if available, contrast is preferred for all neuroimaging) prior to registration; - CT chest with IV contrast (if contrast is available and unless contraindicated, such as for abnormal kidney function) prior to registration. PET/CT may be used if the CT portion is of identical diagnostic quality as achieved in a stand-alone CT - No evidence of distant metastases based on FDG PET/CT scan obtained within 60 days of registration - Primary tumor =< 7 cm - Age >= 18 - Eastern Cooperative Oncology Group (ECOG) performance status 0-2 - Hematologic function (e.g. platelets, leukocytes, hemoglobin) amenable, at the discretion of the treating physician, to allow for treatment with chemotherapy and concurrent radiation therapy - Creatinine clearance >= 25 mL/min by the Cockcroft-Gault (C-G) equation - Subjects with non-malignant pleural effusion are eligible provided the effusion is not known or demonstrated to be an exudative effusion - If a pleural effusion is present, the following criteria must be met to exclude malignant involvement: - When pleural fluid is visible on both the CT scan and on a chest x-ray, a pleuracentesis is required to confirm that the pleural fluid is cytologically negative; - Effusions that are minimal (i.e., not visible on chest x-ray) that are too small to safely tap are eligible - Medical history consistent with the patient being amenable, at the discretion of the treating physician, to allow for treating with consolidation immunotherapy. Patients with known EGFR/ALK/other driver mutation at the time of registration are eligible, and these patients can be treated with consolidation systemic therapy at the discretion of the treating physician - Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen - Negative pregnancy test =< 14 days prior to registration for participants of childbearing potential - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry and, for patients treated in the United States (U.S.), authorization permitting release of personal health information
Exclusion Criteria
- Prior radiotherapy to the study cancer (local recurrence). Prior radiotherapy for a different cancer/condition to the region of the study cancer that would result in overlap of radiation therapy fields that is determined by the treating physician to impede the treatment of the study malignancy - Patients without identifiable primary tumor and at least 1 pathologically enlarged lymph node are not eligible (T3-4N0 or T0N1-3 patients are not eligible). At least 1 radiographically-involved lymph node is required, but pathologic confirmation of involvement is not mandated - Centrally located primary tumor < 2 cm from involved nodal disease that would result in significant overlap of the primary SBRT and nodal radiation fields. This does not include proximity to involved segmental and subsegmental lymph nodes (levels 13 and 14) that would not result in overlap of dose to the proximal bronchial tree or esophagus. Centrally located is defined as within or touching the zone of the proximal bronchial tree, which is a volume 2 cm in all directions around the proximal bronchial tree (carina, right and left main bronchi, right and left upper lobe bronchi, intermedius bronchus, right middle lobe bronchus, lingular bronchus right and left lower lobe bronchi) - Participants who are pregnant or unwilling to discontinue nursing - Participants of childbearing potential (participants who may become pregnant or who may impregnate a partner) unwilling to use highly effective contraceptives during therapy and for the Food and Drug Administration (FDA)-labeled contraception timeframe required after the final dose of the selected systemic therapy regimen, because the treatment in this study may be significantly teratogenic
Study Design
- Phase
- Phase 3
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel Assignment
- Primary Purpose
- Treatment
- Masking
- None (Open Label)
Arm Groups
| Arm | Description | Assigned Intervention |
|---|---|---|
|
Active Comparator Arm I (image guided RT, chemotherapy, immunotherapy) |
Patients undergo conventional IGRT and receive usual care chemotherapy consisting of paclitaxel IV followed by carboplatin IV Q7D during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT during follow-up. |
|
|
Experimental Arm II (SBRT, image guided RT, chemotherapy, immunotherapy) |
Patients undergo SBRT and conventional IGRT and receive standard-of-care chemotherapy consisting of paclitaxel IV followed by carboplatin IV Q7D during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT during follow-up. |
|
Recruiting Locations
University of Alabama at Birmingham Cancer Center
Birmingham 4049979, Alabama 4829764 35233
Birmingham 4049979, Alabama 4829764 35233
The Kirklin Clinic at Acton Road
Birmingham 4049979, Alabama 4829764 35243
Birmingham 4049979, Alabama 4829764 35243
Kingman Regional Medical Center
Kingman 5301067, Arizona 5551752 86401
Kingman 5301067, Arizona 5551752 86401
Cancer Center at Saint Joseph's
Phoenix 5308655, Arizona 5551752 85004
Phoenix 5308655, Arizona 5551752 85004
Banner University Medical Center - Tucson
Tucson 5318313, Arizona 5551752 85719
Tucson 5318313, Arizona 5551752 85719
University of Arizona Cancer Center-North Campus
Tucson 5318313, Arizona 5551752 85719
Tucson 5318313, Arizona 5551752 85719
NEA Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro
Jonesboro 4116834, Arkansas 4099753 72401
Jonesboro 4116834, Arkansas 4099753 72401
University of Arkansas for Medical Sciences
Little Rock 4119403, Arkansas 4099753 72205
Little Rock 4119403, Arkansas 4099753 72205
Contact:
Site Public Contact
501-686-8274
Site Public Contact
501-686-8274
AIS Cancer Center at San Joaquin Community Hospital
Bakersfield 5325738, California 5332921 93301
Bakersfield 5325738, California 5332921 93301
Contact:
Site Public Contact
661-323-4673
Site Public Contact
661-323-4673
Mills-Peninsula Medical Center
Burlingame 5331920, California 5332921 94010
Burlingame 5331920, California 5332921 94010
Palo Alto Medical Foundation-Fremont
Fremont 5350734, California 5332921 94538
Fremont 5350734, California 5332921 94538
Los Angeles General Medical Center
Los Angeles 5368361, California 5332921 90033
Los Angeles 5368361, California 5332921 90033
USC / Norris Comprehensive Cancer Center
Los Angeles 5368361, California 5332921 90033
Los Angeles 5368361, California 5332921 90033
Contact:
Site Public Contact
323-865-0451
Site Public Contact
323-865-0451
Fremont - Rideout Cancer Center
Marysville 5370984, California 5332921 95901
Marysville 5370984, California 5332921 95901
Contact:
Site Public Contact
530-749-4400
Site Public Contact
530-749-4400
Memorial Medical Center
Modesto 5373900, California 5332921 95355
Modesto 5373900, California 5332921 95355
Palo Alto Medical Foundation-Camino Division
Mountain View 5375480, California 5332921 94040
Mountain View 5375480, California 5332921 94040
Palo Alto Medical Foundation Health Care
Palo Alto 5380748, California 5332921 94301
Palo Alto 5380748, California 5332921 94301
Sutter Cancer Centers Radiation Oncology Services-Roseville
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sutter Roseville Medical Center
Roseville 5388881, California 5332921 95661
Roseville 5388881, California 5332921 95661
Sutter Medical Center Sacramento
Sacramento 5389489, California 5332921 95816
Sacramento 5389489, California 5332921 95816
California Pacific Medical Center-Pacific Campus
San Francisco 5391959, California 5332921 94115
San Francisco 5391959, California 5332921 94115
Mills Health Center
San Mateo 5392423, California 5332921 94401
San Mateo 5392423, California 5332921 94401
Sutter Pacific Medical Foundation
Santa Rosa 5393287, California 5332921 95403
Santa Rosa 5393287, California 5332921 95403
Palo Alto Medical Foundation-Sunnyvale
Sunnyvale 5400075, California 5332921 94086
Sunnyvale 5400075, California 5332921 94086
Sutter Solano Medical Center/Cancer Center
Vallejo 5405380, California 5332921 94589
Vallejo 5405380, California 5332921 94589
UCHealth University of Colorado Hospital
Aurora 5412347, Colorado 5417618 80045
Aurora 5412347, Colorado 5417618 80045
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
Rocky Mountain Cancer Centers-Penrose
Colorado Springs 5417598, Colorado 5417618 80907
Colorado Springs 5417598, Colorado 5417618 80907
UCHealth Memorial Hospital Central
Colorado Springs 5417598, Colorado 5417618 80909
Colorado Springs 5417598, Colorado 5417618 80909
Contact:
Site Public Contact
719-365-2406
Site Public Contact
719-365-2406
Memorial Hospital North
Colorado Springs 5417598, Colorado 5417618 80920
Colorado Springs 5417598, Colorado 5417618 80920
Contact:
Site Public Contact
719-364-6700
Site Public Contact
719-364-6700
UCHealth - Cherry Creek
Denver 5419384, Colorado 5417618 80206
Denver 5419384, Colorado 5417618 80206
Poudre Valley Hospital
Fort Collins 5577147, Colorado 5417618 80524
Fort Collins 5577147, Colorado 5417618 80524
Contact:
Site Public Contact
970-297-6150
Site Public Contact
970-297-6150
Cancer Care and Hematology-Fort Collins
Fort Collins 5577147, Colorado 5417618 80528
Fort Collins 5577147, Colorado 5417618 80528
UCHealth Greeley Hospital
Greeley 5577592, Colorado 5417618 80631
Greeley 5577592, Colorado 5417618 80631
UCHealth Highlands Ranch Hospital
Highlands Ranch 5425043, Colorado 5417618 80129
Highlands Ranch 5425043, Colorado 5417618 80129
Contact:
Site Public Contact
720-848-0650
Site Public Contact
720-848-0650
UCHealth Lone Tree Health Center
Lone Tree 5429208, Colorado 5417618 80124
Lone Tree 5429208, Colorado 5417618 80124
Medical Center of the Rockies
Loveland 5579368, Colorado 5417618 80538
Loveland 5579368, Colorado 5417618 80538
Contact:
Site Public Contact
970-203-7083
Site Public Contact
970-203-7083
Beebe Medical Center
Lewes 4143354, Delaware 4142224 19958
Lewes 4143354, Delaware 4142224 19958
Beebe South Coastal Health Campus
Millville 4143696, Delaware 4142224 19967
Millville 4143696, Delaware 4142224 19967
Helen F Graham Cancer Center
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Medical Oncology Hematology Consultants PA
Newark 4143861, Delaware 4142224 19713
Newark 4143861, Delaware 4142224 19713
Christiana Care Health System-Christiana Hospital
Newark 4143861, Delaware 4142224 19718
Newark 4143861, Delaware 4142224 19718
Beebe Health Campus
Rehoboth Beach 4144284, Delaware 4142224 19971
Rehoboth Beach 4144284, Delaware 4142224 19971
Christiana Care Health System-Wilmington Hospital
Wilmington 4145381, Delaware 4142224 19801
Wilmington 4145381, Delaware 4142224 19801
Morton Plant Hospital
Clearwater 4151316, Florida 4155751 33756
Clearwater 4151316, Florida 4155751 33756
Contact:
Site Public Contact
855-314-8646
Site Public Contact
855-314-8646
Halifax Health Medical Center-Centers for Oncology
Daytona Beach 4152872, Florida 4155751 32114
Daytona Beach 4152872, Florida 4155751 32114
Contact:
Site Public Contact
386-254-4211
Site Public Contact
386-254-4211
Mayo Clinic in Florida
Jacksonville 4160021, Florida 4155751 32224-9980
Jacksonville 4160021, Florida 4155751 32224-9980
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Jupiter Medical Center
Jupiter 4160610, Florida 4155751 33458
Jupiter 4160610, Florida 4155751 33458
Contact:
Site Public Contact
561-745-5768
Site Public Contact
561-745-5768
Orlando Health Cancer Institute
Orlando 4167147, Florida 4155751 32806
Orlando 4167147, Florida 4155751 32806
Saint Joseph's Hospital/Children's Hospital-Tampa
Tampa 4174757, Florida 4155751 33607
Tampa 4174757, Florida 4155751 33607
Winter Haven Hospital
Winter Haven 4178552, Florida 4155751 33881
Winter Haven 4178552, Florida 4155751 33881
Grady Health System
Atlanta 4180439, Georgia 4197000 30303
Atlanta 4180439, Georgia 4197000 30303
Contact:
Site Public Contact
404-778-1868
Site Public Contact
404-778-1868
Emory Proton Therapy Center
Atlanta 4180439, Georgia 4197000 30308
Atlanta 4180439, Georgia 4197000 30308
Emory University Hospital Midtown
Atlanta 4180439, Georgia 4197000 30308
Atlanta 4180439, Georgia 4197000 30308
Contact:
Site Public Contact
888-946-7447
Site Public Contact
888-946-7447
Emory University Hospital/Winship Cancer Institute
Atlanta 4180439, Georgia 4197000 30322
Atlanta 4180439, Georgia 4197000 30322
Contact:
Site Public Contact
404-778-1868
Site Public Contact
404-778-1868
Emory Saint Joseph's Hospital
Atlanta 4180439, Georgia 4197000 30342
Atlanta 4180439, Georgia 4197000 30342
Contact:
Site Public Contact
404-851-7115
Site Public Contact
404-851-7115
Augusta University Medical Center
Augusta 4180531, Georgia 4197000 30912
Augusta 4180531, Georgia 4197000 30912
WellStar Cobb Hospital
Austell 4180564, Georgia 4197000 30106
Austell 4180564, Georgia 4197000 30106
Hamilton Medical Center - Peeples Cancer Institute
Dalton 4190581, Georgia 4197000 30720
Dalton 4190581, Georgia 4197000 30720
Wellstar Kennestone Hospital
Marietta 4207783, Georgia 4197000 30060
Marietta 4207783, Georgia 4197000 30060
CTCA at Southeastern Regional Medical Center
Newnan 4212684, Georgia 4197000 30265
Newnan 4212684, Georgia 4197000 30265
Contact:
Site Public Contact
770-400-6629
Site Public Contact
770-400-6629
Hawaii Cancer Care Inc - Waterfront Plaza
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Queen's Cancer Cenrer - POB I
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-532-0315
Site Public Contact
808-532-0315
Queen's Medical Center
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-545-8548
Site Public Contact
808-545-8548
Straub Clinic and Hospital
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-522-4333
Site Public Contact
808-522-4333
University of Hawaii Cancer Center
Honolulu 5856195, Hawaii 5855797 96813
Honolulu 5856195, Hawaii 5855797 96813
Contact:
Site Public Contact
808-586-2979
Site Public Contact
808-586-2979
Kuakini Medical Center
Honolulu 5856195, Hawaii 5855797 96817
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-9816
Site Public Contact
808-547-9816
Queen's Cancer Center - Kuakini
Honolulu 5856195, Hawaii 5855797 96817
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-531-8521
Site Public Contact
808-531-8521
The Cancer Center of Hawaii-Liliha
Honolulu 5856195, Hawaii 5855797 96817
Honolulu 5856195, Hawaii 5855797 96817
Contact:
Site Public Contact
808-547-6881
Site Public Contact
808-547-6881
Hawaii Cancer Care - Westridge
‘Aiea 5856430, Hawaii 5855797 96701
‘Aiea 5856430, Hawaii 5855797 96701
Pali Momi Medical Center
‘Aiea 5856430, Hawaii 5855797 96701
‘Aiea 5856430, Hawaii 5855797 96701
Contact:
Site Public Contact
808-486-6000
Site Public Contact
808-486-6000
Rush-Copley Medical Center
Aurora 4883817, Illinois 4896861 60504
Aurora 4883817, Illinois 4896861 60504
Advocate Outpatient Center - Aurora
Aurora 4883817, Illinois 4896861 60506
Aurora 4883817, Illinois 4896861 60506
Advocate Good Shepherd Hospital
Barrington 4884116, Illinois 4896861 60010
Barrington 4884116, Illinois 4896861 60010
Contact:
Site Public Contact
847-842-4847
Site Public Contact
847-842-4847
OSF Saint Joseph Medical Center
Bloomington 4885164, Illinois 4896861 61701
Bloomington 4885164, Illinois 4896861 61701
Illinois CancerCare-Bloomington
Bloomington 4885164, Illinois 4896861 61704
Bloomington 4885164, Illinois 4896861 61704
Illinois CancerCare-Canton
Canton 4831990, Illinois 4896861 61520
Canton 4831990, Illinois 4896861 61520
Illinois CancerCare-Carthage
Carthage 4886716, Illinois 4896861 62321
Carthage 4886716, Illinois 4896861 62321
Centralia Oncology Clinic
Centralia 4235587, Illinois 4896861 62801
Centralia 4235587, Illinois 4896861 62801
Northwestern University
Chicago 4887398, Illinois 4896861 60611
Chicago 4887398, Illinois 4896861 60611
Advocate Illinois Masonic Medical Center
Chicago 4887398, Illinois 4896861 60657
Chicago 4887398, Illinois 4896861 60657
Contact:
Site Public Contact
773-296-5360
Site Public Contact
773-296-5360
AMG Crystal Lake - Oncology
Crystal Lake 4889229, Illinois 4896861 60014
Crystal Lake 4889229, Illinois 4896861 60014
Carle at The Riverfront
Danville 4889426, Illinois 4896861 61832
Danville 4889426, Illinois 4896861 61832
Cancer Care Specialists of Illinois - Decatur
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Decatur Memorial Hospital
Decatur 4236895, Illinois 4896861 62526
Decatur 4236895, Illinois 4896861 62526
Northwestern Medicine Cancer Center Kishwaukee
DeKalb 4889553, Illinois 4896861 60115
DeKalb 4889553, Illinois 4896861 60115
Advocate Good Samaritan Hospital
Downers Grove 4890119, Illinois 4896861 60515
Downers Grove 4890119, Illinois 4896861 60515
Carle Physician Group-Effingham
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Crossroads Cancer Center
Effingham 4237727, Illinois 4896861 62401
Effingham 4237727, Illinois 4896861 62401
Advocate Sherman Hospital
Elgin 4890864, Illinois 4896861 60123
Elgin 4890864, Illinois 4896861 60123
Contact:
Site Public Contact
847-429-2907
Site Public Contact
847-429-2907
Illinois CancerCare-Eureka
Eureka 4891310, Illinois 4896861 61530
Eureka 4891310, Illinois 4896861 61530
Illinois CancerCare-Galesburg
Galesburg 4893392, Illinois 4896861 61401
Galesburg 4893392, Illinois 4896861 61401
Northwestern Medicine Cancer Center Delnor
Geneva 4893591, Illinois 4896861 60134
Geneva 4893591, Illinois 4896861 60134
Advocate South Suburban Hospital
Hazel Crest 4895416, Illinois 4896861 60429
Hazel Crest 4895416, Illinois 4896861 60429
Contact:
Site Public Contact
708-799-9995
Site Public Contact
708-799-9995
Illinois CancerCare-Kewanee Clinic
Kewanee 4898433, Illinois 4896861 61443
Kewanee 4898433, Illinois 4896861 61443
AMG Libertyville - Oncology
Libertyville 4899739, Illinois 4896861 60048
Libertyville 4899739, Illinois 4896861 60048
Condell Memorial Hospital
Libertyville 4899739, Illinois 4896861 60048
Libertyville 4899739, Illinois 4896861 60048
Illinois CancerCare-Macomb
Macomb 4900817, Illinois 4896861 61455
Macomb 4900817, Illinois 4896861 61455
Carle Physician Group-Mattoon/Charleston
Mattoon 4244099, Illinois 4896861 61938
Mattoon 4244099, Illinois 4896861 61938
Cancer Care Center of O'Fallon
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
HSHS Saint Elizabeth's Hospital
O'Fallon 4245926, Illinois 4896861 62269
O'Fallon 4245926, Illinois 4896861 62269
Advocate Christ Medical Center
Oak Lawn 4904365, Illinois 4896861 60453-2699
Oak Lawn 4904365, Illinois 4896861 60453-2699
Contact:
Site Public Contact
800-323-8622
Site Public Contact
800-323-8622
Illinois CancerCare-Ottawa Clinic
Ottawa 4905006, Illinois 4896861 61350
Ottawa 4905006, Illinois 4896861 61350
Advocate High Tech Medical Park
Palos Heights 4905259, Illinois 4896861 60463
Palos Heights 4905259, Illinois 4896861 60463
Advocate Lutheran General Hospital
Park Ridge 4905367, Illinois 4896861 60068
Park Ridge 4905367, Illinois 4896861 60068
Contact:
Site Public Contact
847-384-3621
Site Public Contact
847-384-3621
Illinois CancerCare-Pekin
Pekin 4905599, Illinois 4896861 61554
Pekin 4905599, Illinois 4896861 61554
Illinois CancerCare-Peoria
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
OSF Saint Francis Radiation Oncology at Peoria Cancer Center
Peoria 4905687, Illinois 4896861 61615
Peoria 4905687, Illinois 4896861 61615
Methodist Medical Center of Illinois
Peoria 4905687, Illinois 4896861 61636
Peoria 4905687, Illinois 4896861 61636
OSF Saint Francis Medical Center
Peoria 4905687, Illinois 4896861 61637
Peoria 4905687, Illinois 4896861 61637
Illinois CancerCare-Peru
Peru 4905770, Illinois 4896861 61354
Peru 4905770, Illinois 4896861 61354
Illinois CancerCare-Princeton
Princeton 4906818, Illinois 4896861 61356
Princeton 4906818, Illinois 4896861 61356
UW Health Carbone Cancer Center Rockford
Rockford 4907959, Illinois 4896861 61114
Rockford 4907959, Illinois 4896861 61114
Southern Illinois University School of Medicine
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
217-545-7929
Site Public Contact
217-545-7929
Springfield Clinic
Springfield 4250542, Illinois 4896861 62702
Springfield 4250542, Illinois 4896861 62702
Contact:
Site Public Contact
800-444-7541
Site Public Contact
800-444-7541
Springfield Memorial Hospital
Springfield 4250542, Illinois 4896861 62781
Springfield 4250542, Illinois 4896861 62781
Carle Cancer Center
Urbana 4914570, Illinois 4896861 61801
Urbana 4914570, Illinois 4896861 61801
Northwestern Medicine Cancer Center Warrenville
Warrenville 4915525, Illinois 4896861 60555
Warrenville 4915525, Illinois 4896861 60555
Illinois CancerCare - Washington
Washington 4915545, Illinois 4896861 61571
Washington 4915545, Illinois 4896861 61571
Midwestern Regional Medical Center
Zion 4917358, Illinois 4896861 60099
Zion 4917358, Illinois 4896861 60099
Contact:
Site Public Contact
844-793-0745
Site Public Contact
844-793-0745
Northwest Cancer Center - Main Campus
Crown Point 4919451, Indiana 4921868 46307
Crown Point 4919451, Indiana 4921868 46307
Contact:
Site Public Contact
219-310-2550
Site Public Contact
219-310-2550
Northwest Oncology LLC
Dyer 4919820, Indiana 4921868 46311
Dyer 4919820, Indiana 4921868 46311
Contact:
Site Public Contact
219-924-8178
Site Public Contact
219-924-8178
Northwest Cancer Center - Hobart
Hobart 4921476, Indiana 4921868 46342
Hobart 4921476, Indiana 4921868 46342
Contact:
Site Public Contact
219-947-1795
Site Public Contact
219-947-1795
Saint Mary Medical Center
Hobart 4921476, Indiana 4921868 46342
Hobart 4921476, Indiana 4921868 46342
The Community Hospital
Munster 4924014, Indiana 4921868 46321
Munster 4924014, Indiana 4921868 46321
Contact:
Site Public Contact
219-836-3349
Site Public Contact
219-836-3349
Women's Diagnostic Center - Munster
Munster 4924014, Indiana 4921868 46321
Munster 4924014, Indiana 4921868 46321
Northwest Cancer Center - Valparaiso
Valparaiso 4927537, Indiana 4921868 46383
Valparaiso 4927537, Indiana 4921868 46383
Mary Greeley Medical Center
Ames 4846834, Iowa 4862182 50010
Ames 4846834, Iowa 4862182 50010
Contact:
Site Public Contact
515-956-4132
Site Public Contact
515-956-4132
McFarland Clinic - Ames
Ames 4846834, Iowa 4862182 50010
Ames 4846834, Iowa 4862182 50010
UI Health Care Mission Cancer and Blood - Ankeny Clinic
Ankeny 4846960, Iowa 4862182 50023
Ankeny 4846960, Iowa 4862182 50023
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Saint Luke's Hospital
Cedar Rapids 4850751, Iowa 4862182 52402
Cedar Rapids 4850751, Iowa 4862182 52402
UI Health Care Mission Cancer and Blood - West Des Moines Clinic
Clive 4852065, Iowa 4862182 50325
Clive 4852065, Iowa 4862182 50325
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
Heartland Oncology and Hematology LLP
Council Bluffs 4852832, Iowa 4862182 51503
Council Bluffs 4852832, Iowa 4862182 51503
Contact:
Site Public Contact
712-322-4136
Site Public Contact
712-322-4136
Methodist Jennie Edmundson Hospital
Council Bluffs 4852832, Iowa 4862182 51503
Council Bluffs 4852832, Iowa 4862182 51503
Iowa Methodist Medical Center
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-6727
Site Public Contact
515-241-6727
UI Health Care Mission Cancer and Blood - Des Moines Clinic
Des Moines 4853828, Iowa 4862182 50309
Des Moines 4853828, Iowa 4862182 50309
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
UI Health Care Mission Cancer and Blood - Laurel Clinic
Des Moines 4853828, Iowa 4862182 50314
Des Moines 4853828, Iowa 4862182 50314
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
UI Health Care Mission Cancer and Blood - Waukee Clinic
Waukee 4880981, Iowa 4862182 50263
Waukee 4880981, Iowa 4862182 50263
Contact:
Site Public Contact
515-241-3305
Site Public Contact
515-241-3305
University of Kansas Cancer Center
Kansas City 4273837, Kansas 4273857 66160
Kansas City 4273837, Kansas 4273857 66160
The University of Kansas Cancer Center - Olathe
Olathe 4276614, Kansas 4273857 66061
Olathe 4276614, Kansas 4273857 66061
University of Kansas Cancer Center-Overland Park
Overland Park 4276873, Kansas 4273857 66210
Overland Park 4276873, Kansas 4273857 66210
Salina Regional Health Center
Salina 4278890, Kansas 4273857 67401
Salina 4278890, Kansas 4273857 67401
University of Kansas Health System Saint Francis Campus
Topeka 4280539, Kansas 4273857 66606
Topeka 4280539, Kansas 4273857 66606
Contact:
Site Public Contact
785-295-8000
Site Public Contact
785-295-8000
University of Kansas Hospital-Westwood Cancer Center
Westwood 4281639, Kansas 4273857 66205
Westwood 4281639, Kansas 4273857 66205
Ascension Via Christi Hospitals Wichita
Wichita 4281730, Kansas 4273857 67214
Wichita 4281730, Kansas 4273857 67214
University of Kentucky/Markey Cancer Center
Lexington 4297983, Kentucky 6254925 40536
Lexington 4297983, Kentucky 6254925 40536
Contact:
Site Public Contact
859-257-3379
Site Public Contact
859-257-3379
Louisiana State University Health Science Center
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
University Medical Center New Orleans
New Orleans 4335045, Louisiana 4331987 70112
New Orleans 4335045, Louisiana 4331987 70112
MaineHealth Maine Medical Center - Portland
Portland 4975802, Maine 4971068 04102
Portland 4975802, Maine 4971068 04102
MaineHealth Cancer Care Center of York County
Sanford 4977762, Maine 4971068 04073
Sanford 4977762, Maine 4971068 04073
Contact:
Site Public Contact
207-459-1600
Site Public Contact
207-459-1600
MaineHealth Maine Medical Center- Scarborough
Scarborough 4977882, Maine 4971068 04074
Scarborough 4977882, Maine 4971068 04074
MaineHealth Cancer Care and IV Therapy - South Portland
South Portland 4979244, Maine 4971068 04106
South Portland 4979244, Maine 4971068 04106
Greater Baltimore Medical Center
Baltimore 4347778, Maryland 4361885 21204
Baltimore 4347778, Maryland 4361885 21204
Contact:
Site Public Contact
443-849-3706
Site Public Contact
443-849-3706
Sinai Hospital of Baltimore
Baltimore 4347778, Maryland 4361885 21215
Baltimore 4347778, Maryland 4361885 21215
Contact:
Site Public Contact
410-601-9083
Site Public Contact
410-601-9083
TidalHealth Richard A Henson Cancer Institute
Ocean Pines 4364326, Maryland 4361885 21811
Ocean Pines 4364326, Maryland 4361885 21811
TidalHealth Peninsula Regional
Salisbury 4368711, Maryland 4361885 21801
Salisbury 4368711, Maryland 4361885 21801
William E Kahlert Regional Cancer Center/Sinai Hospital
Westminster 4373238, Maryland 4361885 21157
Westminster 4373238, Maryland 4361885 21157
Contact:
Site Public Contact
410-871-6400
Site Public Contact
410-871-6400
UMass Memorial Medical Center - University Campus
Worcester 4956184, Massachusetts 6254926 01655
Worcester 4956184, Massachusetts 6254926 01655
Trinity Health Saint Joseph Mercy Hospital Ann Arbor
Ann Arbor 4984247, Michigan 5001836 48106
Ann Arbor 4984247, Michigan 5001836 48106
McLaren Cancer Institute-Bay City
Bay City 4985180, Michigan 5001836 48706
Bay City 4985180, Michigan 5001836 48706
Trinity Health IHA Medical Group Hematology Oncology - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Trinity Health Medical Center - Brighton
Brighton 4986994, Michigan 5001836 48114
Brighton 4986994, Michigan 5001836 48114
Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
Chelsea 4988628, Michigan 5001836 48118
Chelsea 4988628, Michigan 5001836 48118
McLaren Cancer Institute-Clarkston
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
Michigan Healthcare Professionals Clarkston
Clarkston 4988997, Michigan 5001836 48346
Clarkston 4988997, Michigan 5001836 48346
Wayne State University/Karmanos Cancer Institute
Detroit 4990729, Michigan 5001836 48201
Detroit 4990729, Michigan 5001836 48201
Michigan Healthcare Professionals Farmington
Farmington Hills 4992523, Michigan 5001836 48334
Farmington Hills 4992523, Michigan 5001836 48334
Weisberg Cancer Treatment Center
Farmington Hills 4992523, Michigan 5001836 48334
Farmington Hills 4992523, Michigan 5001836 48334
Corewell Health Farmington Hills Hospital
Farmington Hills 4992523, Michigan 5001836 48336
Farmington Hills 4992523, Michigan 5001836 48336
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
McLaren Cancer Institute-Flint
Flint 4992982, Michigan 5001836 48532
Flint 4992982, Michigan 5001836 48532
Trinity Health Grand Rapids Hospital
Grand Rapids 4994358, Michigan 5001836 49503
Grand Rapids 4994358, Michigan 5001836 49503
Bronson Methodist Hospital
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
West Michigan Cancer Center
Kalamazoo 4997787, Michigan 5001836 49007
Kalamazoo 4997787, Michigan 5001836 49007
Beacon Kalamazoo
Kalamazoo 4997787, Michigan 5001836 49048
Kalamazoo 4997787, Michigan 5001836 49048
Contact:
Site Public Contact
574-647-7370
Site Public Contact
574-647-7370
Karmanos Cancer Institute at McLaren Greater Lansing
Lansing 4998830, Michigan 5001836 48910
Lansing 4998830, Michigan 5001836 48910
University of Michigan Health - Sparrow Lansing
Lansing 4998830, Michigan 5001836 48912
Lansing 4998830, Michigan 5001836 48912
McLaren Cancer Institute-Lapeer Region
Lapeer 4998842, Michigan 5001836 48446
Lapeer 4998842, Michigan 5001836 48446
Trinity Health Saint Mary Mercy Livonia Hospital
Livonia 4999837, Michigan 5001836 48154
Livonia 4999837, Michigan 5001836 48154
Michigan Healthcare Professionals Macomb
Macomb 5000473, Michigan 5001836 48044
Macomb 5000473, Michigan 5001836 48044
Michigan Healthcare Professionals Madison Heights
Madison Heights 5000500, Michigan 5001836 48071
Madison Heights 5000500, Michigan 5001836 48071
McLaren Cancer Institute-Macomb
Mount Clemens 5002656, Michigan 5001836 48043
Mount Clemens 5002656, Michigan 5001836 48043
McLaren Cancer Institute-Northern Michigan
Petoskey 5005484, Michigan 5001836 49770
Petoskey 5005484, Michigan 5001836 49770
Michigan Healthcare Professionals Pontiac
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
Trinity Health Saint Joseph Mercy Oakland Hospital
Pontiac 5006166, Michigan 5001836 48341
Pontiac 5006166, Michigan 5001836 48341
McLaren-Port Huron
Port Huron 5006233, Michigan 5001836 48060
Port Huron 5006233, Michigan 5001836 48060
Corewell Health William Beaumont University Hospital
Royal Oak 5007804, Michigan 5001836 48073
Royal Oak 5007804, Michigan 5001836 48073
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Munson Medical Center
Traverse City 5012495, Michigan 5001836 49684
Traverse City 5012495, Michigan 5001836 49684
Corewell Health Beaumont Troy Hospital
Troy 5012639, Michigan 5001836 48085
Troy 5012639, Michigan 5001836 48085
Contact:
Site Public Contact
248-551-7695
Site Public Contact
248-551-7695
Michigan Healthcare Professionals Troy
Troy 5012639, Michigan 5001836 48098
Troy 5012639, Michigan 5001836 48098
Henry Ford Health Warren Hospital
Warren 5014051, Michigan 5001836 48093
Warren 5014051, Michigan 5001836 48093
University of Michigan Health - West
Wyoming 5015618, Michigan 5001836 49519
Wyoming 5015618, Michigan 5001836 49519
Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
Ypsilanti 5015688, Michigan 5001836 48197
Ypsilanti 5015688, Michigan 5001836 48197
Sanford Joe Lueken Cancer Center
Bemidji 5017822, Minnesota 5037779 56601
Bemidji 5017822, Minnesota 5037779 56601
Essentia Health Saint Joseph's Medical Center
Brainerd 5019116, Minnesota 5037779 56401
Brainerd 5019116, Minnesota 5037779 56401
Essentia Health - Deer River Clinic
Deer River 5024099, Minnesota 5037779 56636
Deer River 5024099, Minnesota 5037779 56636
Essentia Health Cancer Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Essentia Health Saint Mary's Medical Center
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Miller-Dwan Hospital
Duluth 5024719, Minnesota 5037779 55805
Duluth 5024719, Minnesota 5037779 55805
Essentia Health Hibbing Clinic
Hibbing 5030005, Minnesota 5037779 55746
Hibbing 5030005, Minnesota 5037779 55746
Contact:
Site Public Contact
218-786-3308
Site Public Contact
218-786-3308
Mayo Clinic in Rochester
Rochester 5043473, Minnesota 5037779 55905
Rochester 5043473, Minnesota 5037779 55905
Contact:
Site Public Contact
855-776-0015
Site Public Contact
855-776-0015
Coborn Cancer Center at Saint Cloud Hospital
Saint Cloud 5044407, Minnesota 5037779 56303
Saint Cloud 5044407, Minnesota 5037779 56303
Essentia Health Sandstone
Sandstone 5045908, Minnesota 5037779 55072
Sandstone 5045908, Minnesota 5037779 55072
Essentia Health Virginia Clinic
Virginia 5051468, Minnesota 5037779 55792
Virginia 5051468, Minnesota 5037779 55792
Baptist Memorial Hospital and Cancer Center-Desoto
Southhaven 4446702, Mississippi 4436296 38671
Southhaven 4446702, Mississippi 4436296 38671
Saint Francis Medical Center
Cape Girardeau 4379966, Missouri 4398678 63703
Cape Girardeau 4379966, Missouri 4398678 63703
Parkland Health Center - Farmington
Farmington 4386289, Missouri 4398678 63640
Farmington 4386289, Missouri 4398678 63640
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Freeman Health System
Joplin 4392768, Missouri 4398678 64804
Joplin 4392768, Missouri 4398678 64804
University of Kansas Cancer Center - North
Kansas City 4393217, Missouri 4398678 64154
Kansas City 4393217, Missouri 4398678 64154
University of Kansas Cancer Center - Lee's Summit
Lee's Summit 4394870, Missouri 4398678 64064
Lee's Summit 4394870, Missouri 4398678 64064
Sainte Genevieve County Memorial Hospital
Sainte Genevieve 4407294, Missouri 4398678 63670
Sainte Genevieve 4407294, Missouri 4398678 63670
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Springfield
Springfield 4409896, Missouri 4398678 65804
Springfield 4409896, Missouri 4398678 65804
Contact:
Site Public Contact
417-269-4520
Site Public Contact
417-269-4520
Mercy Hospital South
St Louis 4407066, Missouri 4398678 63128
St Louis 4407066, Missouri 4398678 63128
Missouri Baptist Medical Center
St Louis 4407066, Missouri 4398678 63131
St Louis 4407066, Missouri 4398678 63131
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Mercy Hospital Saint Louis
St Louis 4407066, Missouri 4398678 63141
St Louis 4407066, Missouri 4398678 63141
Contact:
Site Public Contact
314-251-7066
Site Public Contact
314-251-7066
Missouri Baptist Sullivan Hospital
Sullivan 4410669, Missouri 4398678 63080
Sullivan 4410669, Missouri 4398678 63080
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
BJC Outpatient Center at Sunset Hills
Sunset Hills 4410836, Missouri 4398678 63127
Sunset Hills 4410836, Missouri 4398678 63127
Contact:
Site Public Contact
314-996-5569
Site Public Contact
314-996-5569
Billings Clinic Cancer Center
Billings 5640350, Montana 5667009 59101
Billings 5640350, Montana 5667009 59101
Bozeman Health Deaconess Hospital
Bozeman 5641727, Montana 5667009 59715
Bozeman 5641727, Montana 5667009 59715
Benefis Sletten Cancer Institute
Great Falls 5655240, Montana 5667009 59405
Great Falls 5655240, Montana 5667009 59405
Nebraska Cancer Specialists/Oncology Hematology West PC - MECC
Omaha 5074472, Nebraska 5073708 68114
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-334-4773
Site Public Contact
402-334-4773
Nebraska Methodist Hospital
Omaha 5074472, Nebraska 5073708 68114
Omaha 5074472, Nebraska 5073708 68114
Contact:
Site Public Contact
402-354-5144
Site Public Contact
402-354-5144
Renown Regional Medical Center
Reno 5511077, Nevada 5509151 89502
Reno 5511077, Nevada 5509151 89502
Dartmouth Hitchcock Medical Center/Dartmouth Cancer Center
Lebanon 5088597, New Hampshire 5090174 03756
Lebanon 5088597, New Hampshire 5090174 03756
Memorial Sloan Kettering Basking Ridge
Basking Ridge 5095409, New Jersey 5101760 07920
Basking Ridge 5095409, New Jersey 5101760 07920
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Cooper Hospital University Medical Center
Camden 4501018, New Jersey 5101760 08103
Camden 4501018, New Jersey 5101760 08103
Contact:
Site Public Contact
856-325-6757
Site Public Contact
856-325-6757
The Cancer Institute of New Jersey Hamilton
Hamilton 5098765, New Jersey 5101760 08690
Hamilton 5098765, New Jersey 5101760 08690
Contact:
Site Public Contact
609-631-6946
Site Public Contact
609-631-6946
Jersey City Medical Center
Jersey City 5099836, New Jersey 5101760 07302
Jersey City 5099836, New Jersey 5101760 07302
Monmouth Medical Center Southern Campus
Lakewood 5100280, New Jersey 5101760 08701
Lakewood 5100280, New Jersey 5101760 08701
Saint Barnabas Medical Center
Livingston 5100572, New Jersey 5101760 07039
Livingston 5100572, New Jersey 5101760 07039
Monmouth Medical Center
Long Branch 5100619, New Jersey 5101760 07740
Long Branch 5100619, New Jersey 5101760 07740
Memorial Sloan Kettering Monmouth
Middletown 5101170, New Jersey 5101760 07748
Middletown 5101170, New Jersey 5101760 07748
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Memorial Sloan Kettering Bergen
Montvale 5101361, New Jersey 5101760 07645
Montvale 5101361, New Jersey 5101760 07645
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Rutgers Cancer Institute of New Jersey
New Brunswick 5101717, New Jersey 5101760 08903
New Brunswick 5101717, New Jersey 5101760 08903
Contact:
Site Public Contact
732-235-7356
Site Public Contact
732-235-7356
Rutgers New Jersey Medical School
Newark 5101798, New Jersey 5101760 07101
Newark 5101798, New Jersey 5101760 07101
Contact:
Site Public Contact
732-235-7356
Site Public Contact
732-235-7356
Sidney Kimmel Cancer Center Washington Township
Sewell 4504048, New Jersey 5101760 08080
Sewell 4504048, New Jersey 5101760 08080
Robert Wood Johnson University Hospital Somerset
Somerville 5104774, New Jersey 5101760 08876
Somerville 5104774, New Jersey 5101760 08876
Community Medical Center
Toms River 4504476, New Jersey 5101760 08755
Toms River 4504476, New Jersey 5101760 08755
University of New Mexico Cancer Center
Albuquerque 5454711, New Mexico 5481136 87106
Albuquerque 5454711, New Mexico 5481136 87106
Presbyterian Kaseman Hospital
Albuquerque 5454711, New Mexico 5481136 87110
Albuquerque 5454711, New Mexico 5481136 87110
Memorial Medical Center-Las Cruces
Las Cruces 5475352, New Mexico 5481136 88011
Las Cruces 5475352, New Mexico 5481136 88011
Presbyterian Rust Medical Center/Jorgensen Cancer Center
Rio Rancho 5487811, New Mexico 5481136 87124
Rio Rancho 5487811, New Mexico 5481136 87124
Wilmot Cancer Center at Batavia
Batavia 5108093, New York 5128638 14020
Batavia 5108093, New York 5128638 14020
Sands Cancer Center
Canandaigua 5111405, New York 5128638 14424
Canandaigua 5111405, New York 5128638 14424
Contact:
Site Public Contact
585-396-6161
Site Public Contact
585-396-6161
Memorial Sloan Kettering Commack
Commack 5113412, New York 5128638 11725
Commack 5113412, New York 5128638 11725
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Glens Falls Hospital
Glens Falls 5118693, New York 5128638 12801
Glens Falls 5118693, New York 5128638 12801
Contact:
Site Public Contact
518-926-6700
Site Public Contact
518-926-6700
Memorial Sloan Kettering Westchester
Harrison 5120095, New York 5128638 10604
Harrison 5120095, New York 5128638 10604
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
New York Proton Center
New York 5128581, New York 5128638 10035
New York 5128581, New York 5128638 10035
Memorial Sloan Kettering Cancer Center
New York 5128581, New York 5128638 10065
New York 5128581, New York 5128638 10065
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Wilmot Cancer Institute Radiation Oncology at Greece
Rochester 5134086, New York 5128638 14606
Rochester 5134086, New York 5128638 14606
Contact:
Site Public Contact
585-758-7877
Site Public Contact
585-758-7877
Highland Hospital
Rochester 5134086, New York 5128638 14620
Rochester 5134086, New York 5128638 14620
Contact:
Site Public Contact
585-341-8113
Site Public Contact
585-341-8113
University of Rochester
Rochester 5134086, New York 5128638 14642
Rochester 5134086, New York 5128638 14642
Contact:
Site Public Contact
585-275-5830
Site Public Contact
585-275-5830
Stony Brook University Medical Center
Stony Brook 5139865, New York 5128638 11794
Stony Brook 5139865, New York 5128638 11794
Contact:
Site Public Contact
800-862-2215
Site Public Contact
800-862-2215
State University of New York Upstate Medical University
Syracuse 5140405, New York 5128638 13210
Syracuse 5140405, New York 5128638 13210
Contact:
Site Public Contact
315-464-5476
Site Public Contact
315-464-5476
Montefiore Medical Center-Einstein Campus
The Bronx 5110266, New York 5128638 10461
The Bronx 5110266, New York 5128638 10461
Montefiore Medical Center-Weiler Hospital
The Bronx 5110266, New York 5128638 10461
The Bronx 5110266, New York 5128638 10461
Montefiore Medical Center - Moses Campus
The Bronx 5110266, New York 5128638 10467
The Bronx 5110266, New York 5128638 10467
Memorial Sloan Kettering Nassau
Uniondale 5141927, New York 5128638 11553
Uniondale 5141927, New York 5128638 11553
Contact:
Site Public Contact
212-639-7592
Site Public Contact
212-639-7592
Westchester Medical Center
Valhalla 5142090, New York 5128638 10595
Valhalla 5142090, New York 5128638 10595
Wilmot Cancer Institute at Webster
Webster 5143495, New York 5128638 14580
Webster 5143495, New York 5128638 14580
Atrium Health Stanly/LCI-Albemarle
Albemarle 4452303, North Carolina 4482348 28002
Albemarle 4452303, North Carolina 4482348 28002
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Duke Cancer Center Cary
Cary 4459467, North Carolina 4482348 27518
Cary 4459467, North Carolina 4482348 27518
UNC Lineberger Comprehensive Cancer Center
Chapel Hill 4460162, North Carolina 4482348 27599
Chapel Hill 4460162, North Carolina 4482348 27599
Carolinas Medical Center/Levine Cancer Institute
Charlotte 4460243, North Carolina 4482348 28203
Charlotte 4460243, North Carolina 4482348 28203
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Novant Health Presbyterian Medical Center
Charlotte 4460243, North Carolina 4482348 28204
Charlotte 4460243, North Carolina 4482348 28204
Atrium Health Pineville/LCI-Pineville
Charlotte 4460243, North Carolina 4482348 28210
Charlotte 4460243, North Carolina 4482348 28210
Contact:
Site Public Contact
980-442-2000
Site Public Contact
980-442-2000
Atrium Health University City/LCI-University
Charlotte 4460243, North Carolina 4482348 28262
Charlotte 4460243, North Carolina 4482348 28262
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Wake Forest University at Clemmons
Clemmons 4461015, North Carolina 4482348 27012
Clemmons 4461015, North Carolina 4482348 27012
Contact:
Site Public Contact
888-716-9259
Site Public Contact
888-716-9259
Atrium Health Cabarrus/LCI-Concord
Concord 4461574, North Carolina 4482348 28025
Concord 4461574, North Carolina 4482348 28025
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Duke University Medical Center
Durham 4464368, North Carolina 4482348 27710
Durham 4464368, North Carolina 4482348 27710
Contact:
Site Public Contact
888-275-3853
Site Public Contact
888-275-3853
Levine Cancer Institute - Rutherford
Forest City 4466720, North Carolina 4482348 28043
Forest City 4466720, North Carolina 4482348 28043
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
CaroMont Regional Medical Center
Gastonia 4467732, North Carolina 4482348 28054
Gastonia 4467732, North Carolina 4482348 28054
Novant Health Breast Surgery - Greensboro
Greensboro 4469146, North Carolina 4482348 27403
Greensboro 4469146, North Carolina 4482348 27403
Novant Health Cancer Institute - Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Huntersville 4472370, North Carolina 4482348 28078
Novant Health Presbyterian Medical Center Huntersville
Huntersville 4472370, North Carolina 4482348 28078
Huntersville 4472370, North Carolina 4482348 28078
Novant Health Cancer Institute - Kernersville
Kernersville 4474221, North Carolina 4482348 27284
Kernersville 4474221, North Carolina 4482348 27284
Levine Cancer Institute - Union West
Matthews 4478334, North Carolina 4482348 28104
Matthews 4478334, North Carolina 4482348 28104
Contact:
Site Public Contact
980-442-0600
Site Public Contact
980-442-0600
Matthews Radiation Oncology Center
Matthews 4478334, North Carolina 4482348 28105
Matthews 4478334, North Carolina 4482348 28105
Novant Health Cancer Institute - Matthews
Matthews 4478334, North Carolina 4482348 28105
Matthews 4478334, North Carolina 4482348 28105
Atrium Health Union/LCI-Union
Monroe 4479946, North Carolina 4482348 28112
Monroe 4479946, North Carolina 4482348 28112
Contact:
Site Public Contact
980-442-2000
Site Public Contact
980-442-2000
Novant Health Cancer Institute - Mooresville
Mooresville 4480125, North Carolina 4482348 28117
Mooresville 4480125, North Carolina 4482348 28117
Novant Health Cancer Institute - Mount Airy
Mount Airy 4480378, North Carolina 4482348 27030
Mount Airy 4480378, North Carolina 4482348 27030
Novant Health Cancer Institute - Wilkesboro
North Wilkesboro 4482577, North Carolina 4482348 28659
North Wilkesboro 4482577, North Carolina 4482348 28659
Duke Cancer Center Raleigh
Raleigh 4487042, North Carolina 4482348 27609
Raleigh 4487042, North Carolina 4482348 27609
Novant Health Cancer Institute - Rowan
Salisbury 4489985, North Carolina 4482348 28144
Salisbury 4489985, North Carolina 4482348 28144
Rowan Regional Medical Center
Salisbury 4489985, North Carolina 4482348 28144
Salisbury 4489985, North Carolina 4482348 28144
Atrium Health Cleveland/LCI-Cleveland
Shelby 4491180, North Carolina 4482348 28150
Shelby 4491180, North Carolina 4482348 28150
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Novant Health Cancer Institute - Statesville
Statesville 4493316, North Carolina 4482348 28625
Statesville 4493316, North Carolina 4482348 28625
Wake Forest Baptist Health - Hematology Oncology - Statesville
Statesville 4493316, North Carolina 4482348 28677
Statesville 4493316, North Carolina 4482348 28677
Contact:
Site Public Contact
704-872-3630
Site Public Contact
704-872-3630
Novant Cancer Institute Radiation Oncology - Supply
Supply 4830472, North Carolina 4482348 28462
Supply 4830472, North Carolina 4482348 28462
Contact:
Site Public Contact
910-754-4716
Site Public Contact
910-754-4716
Novant Health Cancer Institute - Thomasville
Thomasville 4494942, North Carolina 4482348 27360
Thomasville 4494942, North Carolina 4482348 27360
Wake Forest Baptist Health - Wilkes Medical Center
Wilkesboro 4499138, North Carolina 4482348 28659
Wilkesboro 4499138, North Carolina 4482348 28659
Contact:
Site Public Contact
888-716-9253
Site Public Contact
888-716-9253
Novant Health Cancer Institute Radiation Oncology - Wilmington
Wilmington 4499379, North Carolina 4482348 28401
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-251-1839
Site Public Contact
910-251-1839
Novant Health New Hanover Regional Medical Center
Wilmington 4499379, North Carolina 4482348 28401
Wilmington 4499379, North Carolina 4482348 28401
Contact:
Site Public Contact
910-342-3000
Site Public Contact
910-342-3000
Novant Health Forsyth Medical Center
Winston-Salem 4499612, North Carolina 4482348 27103
Winston-Salem 4499612, North Carolina 4482348 27103
Wake Forest University Health Sciences
Winston-Salem 4499612, North Carolina 4482348 27157
Winston-Salem 4499612, North Carolina 4482348 27157
Contact:
Site Public Contact
336-713-6771
Site Public Contact
336-713-6771
Sanford Bismarck Medical Center
Bismarck 5688025, North Dakota 5690763 58501
Bismarck 5688025, North Dakota 5690763 58501
Sanford Broadway Medical Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Sanford Roger Maris Cancer Center
Fargo 5059163, North Dakota 5690763 58122
Fargo 5059163, North Dakota 5690763 58122
Altru Cancer Center
Grand Forks 5059429, North Dakota 5690763 58201
Grand Forks 5059429, North Dakota 5690763 58201
Contact:
Site Public Contact
701-780-6520
Site Public Contact
701-780-6520
Cleveland Clinic Akron General
Akron 5145476, Ohio 5165418 44307
Akron 5145476, Ohio 5165418 44307
UH Seidman Cancer Center at UH Avon Health Center
Avon 5146277, Ohio 5165418 44011
Avon 5146277, Ohio 5165418 44011
Contact:
Site Public Contact
800-641-2422
Site Public Contact
800-641-2422
UHHS-Chagrin Highlands Medical Center
Beachwood 5146711, Ohio 5165418 44122
Beachwood 5146711, Ohio 5165418 44122
Cleveland Clinic Mercy Hospital
Canton 5149222, Ohio 5165418 44708
Canton 5149222, Ohio 5165418 44708
Contact:
Site Public Contact
888-293-4673
Site Public Contact
888-293-4673
Aultman Health Foundation
Canton 5149222, Ohio 5165418 44710
Canton 5149222, Ohio 5165418 44710
Miami Valley Hospital South
Centerville 4508204, Ohio 5165418 45459
Centerville 4508204, Ohio 5165418 45459
Case Western Reserve University
Cleveland 5150529, Ohio 5165418 44106
Cleveland 5150529, Ohio 5165418 44106
Riverside Methodist Hospital
Columbus 4509177, Ohio 5165418 43214
Columbus 4509177, Ohio 5165418 43214
Grant Medical Center
Columbus 4509177, Ohio 5165418 43215
Columbus 4509177, Ohio 5165418 43215
Doctors Hospital
Columbus 4509177, Ohio 5165418 43228
Columbus 4509177, Ohio 5165418 43228
Miami Valley Hospital
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Premier Blood and Cancer Center
Dayton 4509884, Ohio 5165418 45409
Dayton 4509884, Ohio 5165418 45409
Contact:
Site Public Contact
937-276-8320
Site Public Contact
937-276-8320
Miami Valley Hospital North
Dayton 4509884, Ohio 5165418 45415
Dayton 4509884, Ohio 5165418 45415
Delaware Health Center-Grady Cancer Center
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Grady Memorial Hospital
Delaware 5151891, Ohio 5165418 43015
Delaware 5151891, Ohio 5165418 43015
Dublin Methodist Hospital
Dublin 5152333, Ohio 5165418 43016
Dublin 5152333, Ohio 5165418 43016
Atrium Medical Center-Middletown Regional Hospital
Franklin 4512203, Ohio 5165418 45005-1066
Franklin 4512203, Ohio 5165418 45005-1066
Miami Valley Cancer Care and Infusion
Greenville 5156493, Ohio 5165418 45331
Greenville 5156493, Ohio 5165418 45331
Contact:
Site Public Contact
937-569-7515
Site Public Contact
937-569-7515
OhioHealth Mansfield Hospital
Mansfield 5161723, Ohio 5165418 44903
Mansfield 5161723, Ohio 5165418 44903
OhioHealth Marion General Hospital
Marion 5161902, Ohio 5165418 43302
Marion 5161902, Ohio 5165418 43302
UH Seidman Cancer Center at Lake Health Mentor Campus
Mentor 5162645, Ohio 5165418 44060
Mentor 5162645, Ohio 5165418 44060
Mercy Health - Perrysburg Hospital
Perrysburg 5166516, Ohio 5165418 43551
Perrysburg 5166516, Ohio 5165418 43551
Upper Valley Medical Center
Troy 5174358, Ohio 5165418 45373
Troy 5174358, Ohio 5165418 45373
University of Oklahoma Health Sciences Center
Oklahoma City 4544349, Oklahoma 4544379 73104
Oklahoma City 4544349, Oklahoma 4544379 73104
Legacy Mount Hood Medical Center
Gresham 5729485, Oregon 5744337 97030
Gresham 5729485, Oregon 5744337 97030
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Legacy Good Samaritan Hospital and Medical Center
Portland 5746545, Oregon 5744337 97210
Portland 5746545, Oregon 5744337 97210
Legacy Meridian Park Hospital
Tualatin 5757506, Oregon 5744337 97062
Tualatin 5757506, Oregon 5744337 97062
Contact:
Site Public Contact
503-413-1742
Site Public Contact
503-413-1742
Christiana Care Health System-Concord Health Center
Chadds Ford 4557084, Pennsylvania 6254927 19317
Chadds Ford 4557084, Pennsylvania 6254927 19317
Chambersburg Hospital
Chambersburg 4557109, Pennsylvania 6254927 17201
Chambersburg 4557109, Pennsylvania 6254927 17201
Geisinger Medical Center
Danville 5186327, Pennsylvania 6254927 17822
Danville 5186327, Pennsylvania 6254927 17822
Ephrata Cancer Center
Ephrata 5188815, Pennsylvania 6254927 17522
Ephrata 5188815, Pennsylvania 6254927 17522
Contact:
Site Public Contact
717-721-4840
Site Public Contact
717-721-4840
Adams Cancer Center
Gettysburg 4558183, Pennsylvania 6254927 17325
Gettysburg 4558183, Pennsylvania 6254927 17325
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
Penn State Milton S Hershey Medical Center
Hershey 5193342, Pennsylvania 6254927 17033-0850
Hershey 5193342, Pennsylvania 6254927 17033-0850
Lancaster General Ann B Barshinger Cancer Institute
Lancaster 5197079, Pennsylvania 6254927 17601
Lancaster 5197079, Pennsylvania 6254927 17601
Sechler Family Cancer Center
Lebanon 5197517, Pennsylvania 6254927 17042
Lebanon 5197517, Pennsylvania 6254927 17042
Geisinger Medical Oncology-Lewisburg
Lewisburg 5197842, Pennsylvania 6254927 17837
Lewisburg 5197842, Pennsylvania 6254927 17837
University of Pennsylvania/Abramson Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19104
Philadelphia 4560349, Pennsylvania 6254927 19104
Thomas Jefferson University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19107
Philadelphia 4560349, Pennsylvania 6254927 19107
Fox Chase Cancer Center
Philadelphia 4560349, Pennsylvania 6254927 19111
Philadelphia 4560349, Pennsylvania 6254927 19111
Contact:
Site Public Contact
215-728-4790
Site Public Contact
215-728-4790
Temple University Hospital
Philadelphia 4560349, Pennsylvania 6254927 19140
Philadelphia 4560349, Pennsylvania 6254927 19140
Contact:
Site Public Contact
215-728-2983
Site Public Contact
215-728-2983
Reading Hospital
West Reading 5218867, Pennsylvania 6254927 19611
West Reading 5218867, Pennsylvania 6254927 19611
Contact:
Site Public Contact
610-988-9323
Site Public Contact
610-988-9323
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Wilkes-Barre 5219488, Pennsylvania 6254927 18711
Asplundh Cancer Pavilion
Willow Grove 5219619, Pennsylvania 6254927 19090
Willow Grove 5219619, Pennsylvania 6254927 19090
Lankenau Medical Center
Wynnewood 5220230, Pennsylvania 6254927 19096
Wynnewood 5220230, Pennsylvania 6254927 19096
WellSpan Health-York Cancer Center
York 4562407, Pennsylvania 6254927 17403
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
WellSpan Health-York Hospital
York 4562407, Pennsylvania 6254927 17403
York 4562407, Pennsylvania 6254927 17403
Contact:
Site Public Contact
877-441-7957
Site Public Contact
877-441-7957
Gibbs Cancer Center-Gaffney
Gaffney 4579418, South Carolina 4597040 29341
Gaffney 4579418, South Carolina 4597040 29341
Gibbs Cancer Center-Pelham
Greer 4580599, South Carolina 4597040 29651
Greer 4580599, South Carolina 4597040 29651
Lancaster Radiation Therapy Center
Lancaster 4584556, South Carolina 4597040 29720
Lancaster 4584556, South Carolina 4597040 29720
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Rock Hill Radiation Therapy Center
Rock Hill 4593142, South Carolina 4597040 29730
Rock Hill 4593142, South Carolina 4597040 29730
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Levine Cancer Institute-Rock Hill
Rock Hill 4593142, South Carolina 4597040 29732
Rock Hill 4593142, South Carolina 4597040 29732
Contact:
Site Public Contact
800-804-9376
Site Public Contact
800-804-9376
Spartanburg Medical Center
Spartanburg 4597200, South Carolina 4597040 29303
Spartanburg 4597200, South Carolina 4597040 29303
SMC Center for Hematology Oncology Union
Union 4599214, South Carolina 4597040 29379
Union 4599214, South Carolina 4597040 29379
Lexington Medical Center
West Columbia 4600541, South Carolina 4597040 29169
West Columbia 4600541, South Carolina 4597040 29169
Sanford Cancer Center Oncology Clinic
Sioux Falls 5231851, South Dakota 5769223 57104
Sioux Falls 5231851, South Dakota 5769223 57104
Sanford USD Medical Center - Sioux Falls
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Sioux Falls 5231851, South Dakota 5769223 57117-5134
Baptist Memorial Hospital and Cancer Center-Collierville
Collierville 4614748, Tennessee 4662168 38017
Collierville 4614748, Tennessee 4662168 38017
Baptist Memorial Hospital and Cancer Center-Memphis
Memphis 4641239, Tennessee 4662168 38120
Memphis 4641239, Tennessee 4662168 38120
MD Anderson in The Woodlands
Conroe 4682991, Texas 4736286 77384
Conroe 4682991, Texas 4736286 77384
M D Anderson Cancer Center
Houston 4699066, Texas 4736286 77030
Houston 4699066, Texas 4736286 77030
MD Anderson West Houston
Houston 4699066, Texas 4736286 77079
Houston 4699066, Texas 4736286 77079
MD Anderson League City
League City 4705692, Texas 4736286 77573
League City 4705692, Texas 4736286 77573
MD Anderson in Sugar Land
Sugar Land 4734825, Texas 4736286 77478
Sugar Land 4734825, Texas 4736286 77478
Central Vermont Medical Center/National Life Cancer Treatment
Berlin Corners 5233780, Vermont 5242283 05602
Berlin Corners 5233780, Vermont 5242283 05602
Contact:
Site Public Contact
802-225-5400
Site Public Contact
802-225-5400
University of Vermont Medical Center
Burlington 5234372, Vermont 5242283 05401
Burlington 5234372, Vermont 5242283 05401
University of Vermont and State Agricultural College
Burlington 5234372, Vermont 5242283 05405
Burlington 5234372, Vermont 5242283 05405
Dartmouth Cancer Center - North
Saint Johnsbury 5240656, Vermont 5242283 05819
Saint Johnsbury 5240656, Vermont 5242283 05819
Legacy Cancer Institute Medical Oncology and Day Treatment
Vancouver 5814616, Washington 5815135 98684
Vancouver 5814616, Washington 5815135 98684
Legacy Salmon Creek Hospital
Vancouver 5814616, Washington 5815135 98686
Vancouver 5814616, Washington 5815135 98686
Contact:
Site Public Contact
503-413-2150
Site Public Contact
503-413-2150
Edwards Comprehensive Cancer Center
Huntington 4809537, West Virginia 4826850 25701
Huntington 4809537, West Virginia 4826850 25701
West Virginia University Healthcare
Morgantown 4815352, West Virginia 4826850 26506
Morgantown 4815352, West Virginia 4826850 26506
Langlade Hospital and Cancer Center
Antigo 5244010, Wisconsin 5279468 54409
Antigo 5244010, Wisconsin 5279468 54409
Duluth Clinic Ashland
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
Northwest Wisconsin Cancer Center
Ashland 5244247, Wisconsin 5279468 54806
Ashland 5244247, Wisconsin 5279468 54806
Aurora Cancer Care-Southern Lakes VLCC
Burlington 5247214, Wisconsin 5279468 53105
Burlington 5247214, Wisconsin 5279468 53105
Marshfield Medical Center-EC Cancer Center
Eau Claire 5251436, Wisconsin 5279468 54701
Eau Claire 5251436, Wisconsin 5279468 54701
Aurora Health Care Germantown Health Center
Germantown 5254218, Wisconsin 5279468 53022
Germantown 5254218, Wisconsin 5279468 53022
Aurora Cancer Care-Grafton
Grafton 5254739, Wisconsin 5279468 53024
Grafton 5254739, Wisconsin 5279468 53024
Saint Vincent Hospital Cancer Center Green Bay
Green Bay 5254962, Wisconsin 5279468 54301
Green Bay 5254962, Wisconsin 5279468 54301
Aurora BayCare Medical Center
Green Bay 5254962, Wisconsin 5279468 54311
Green Bay 5254962, Wisconsin 5279468 54311
Essentia Health-Hayward Clinic
Hayward 5255882, Wisconsin 5279468 54843
Hayward 5255882, Wisconsin 5279468 54843
University of Wisconsin Carbone Cancer Center - Johnson Creek
Johnson Creek 5257996, Wisconsin 5279468 53038
Johnson Creek 5257996, Wisconsin 5279468 53038
Aurora Cancer Care-Kenosha South
Kenosha 5258393, Wisconsin 5279468 53142
Kenosha 5258393, Wisconsin 5279468 53142
William S Middleton VA Medical Center
Madison 5261457, Wisconsin 5279468 53705
Madison 5261457, Wisconsin 5279468 53705
Contact:
Site Public Contact
608-256-1901
Site Public Contact
608-256-1901
University of Wisconsin Carbone Cancer Center - Eastpark Medical Center
Madison 5261457, Wisconsin 5279468 53718
Madison 5261457, Wisconsin 5279468 53718
University of Wisconsin Carbone Cancer Center - University Hospital
Madison 5261457, Wisconsin 5279468 53792
Madison 5261457, Wisconsin 5279468 53792
Aurora Bay Area Medical Group-Marinette
Marinette 5261852, Wisconsin 5279468 54143
Marinette 5261852, Wisconsin 5279468 54143
Marshfield Medical Center-Marshfield
Marshfield 5261969, Wisconsin 5279468 54449
Marshfield 5261969, Wisconsin 5279468 54449
Froedtert Menomonee Falls Hospital
Menomonee Falls 5262630, Wisconsin 5279468 53051
Menomonee Falls 5262630, Wisconsin 5279468 53051
Contact:
Site Public Contact
262-257-5100
Site Public Contact
262-257-5100
Aurora Cancer Care-Milwaukee
Milwaukee 5263045, Wisconsin 5279468 53209
Milwaukee 5263045, Wisconsin 5279468 53209
Aurora Saint Luke's Medical Center
Milwaukee 5263045, Wisconsin 5279468 53215
Milwaukee 5263045, Wisconsin 5279468 53215
Medical College of Wisconsin
Milwaukee 5263045, Wisconsin 5279468 53226
Milwaukee 5263045, Wisconsin 5279468 53226
Contact:
Site Public Contact
414-805-3666
Site Public Contact
414-805-3666
Aurora Sinai Medical Center
Milwaukee 5263045, Wisconsin 5279468 53233
Milwaukee 5263045, Wisconsin 5279468 53233
Zablocki Veterans Administration Medical Center
Milwaukee 5263045, Wisconsin 5279468 53295
Milwaukee 5263045, Wisconsin 5279468 53295
Contact:
Site Public Contact
888-469-6614
Site Public Contact
888-469-6614
Marshfield Medical Center - Minocqua
Minocqua 5263156, Wisconsin 5279468 54548
Minocqua 5263156, Wisconsin 5279468 54548
ProHealth D N Greenwald Center
Mukwonago 5263965, Wisconsin 5279468 53149
Mukwonago 5263965, Wisconsin 5279468 53149
Drexel Town Square Health Center
Oak Creek 5265228, Wisconsin 5279468 53154
Oak Creek 5265228, Wisconsin 5279468 53154
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
ProHealth Oconomowoc Memorial Hospital
Oconomowoc 5265499, Wisconsin 5279468 53066
Oconomowoc 5265499, Wisconsin 5279468 53066
Contact:
Site Public Contact
262-928-7878
Site Public Contact
262-928-7878
Vince Lombardi Cancer Clinic - Oshkosh
Oshkosh 5265838, Wisconsin 5279468 54904
Oshkosh 5265838, Wisconsin 5279468 54904
Aurora Cancer Care-Racine
Racine 5268249, Wisconsin 5279468 53406
Racine 5268249, Wisconsin 5279468 53406
Aspirus Cancer Care - James Beck Cancer Center
Rhinelander 5268720, Wisconsin 5279468 54501
Rhinelander 5268720, Wisconsin 5279468 54501
Marshfield Medical Center-Rice Lake
Rice Lake 5268798, Wisconsin 5279468 54868
Rice Lake 5268798, Wisconsin 5279468 54868
Saint Vincent Hospital Cancer Center at Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan 5272893, Wisconsin 5279468 53081
Sheboygan 5272893, Wisconsin 5279468 53081
Essentia Health-Spooner Clinic
Spooner 5274034, Wisconsin 5279468 54801
Spooner 5274034, Wisconsin 5279468 54801
Aspirus Cancer Care - Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54481
Stevens Point 5274644, Wisconsin 5279468 54481
Marshfield Medical Center-River Region at Stevens Point
Stevens Point 5274644, Wisconsin 5279468 54482
Stevens Point 5274644, Wisconsin 5279468 54482
Saint Vincent Hospital Cancer Center at Sturgeon Bay
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Sturgeon Bay 5274867, Wisconsin 5279468 54235-1495
Aurora Medical Center in Summit
Summit, Wisconsin 5279468 53066
Summit, Wisconsin 5279468 53066
Essentia Health Saint Mary's Hospital - Superior
Superior 5275191, Wisconsin 5279468 54880
Superior 5275191, Wisconsin 5279468 54880
Contact:
Site Public Contact
701-364-6272
Site Public Contact
701-364-6272
UW Cancer Center at ProHealth Care
Waukesha 5278052, Wisconsin 5279468 53188
Waukesha 5278052, Wisconsin 5279468 53188
Aspirus Regional Cancer Center
Wausau 5278120, Wisconsin 5279468 54401
Wausau 5278120, Wisconsin 5279468 54401
Contact:
Site Public Contact
877-405-6866
Site Public Contact
877-405-6866
Aurora Cancer Care-Milwaukee West
Wauwatosa 5278159, Wisconsin 5279468 53226
Wauwatosa 5278159, Wisconsin 5279468 53226
Aurora West Allis Medical Center
West Allis 5278420, Wisconsin 5279468 53227
West Allis 5278420, Wisconsin 5279468 53227
Froedtert West Bend Hospital/Kraemer Cancer Center
West Bend 5278422, Wisconsin 5279468 53095
West Bend 5278422, Wisconsin 5279468 53095
Contact:
Site Public Contact
414-805-0505
Site Public Contact
414-805-0505
Marshfield Medical Center - Weston
Weston 5278693, Wisconsin 5279468 54476
Weston 5278693, Wisconsin 5279468 54476
Aspirus Cancer Care - Wisconsin Rapids
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Wisconsin Rapids 5279436, Wisconsin 5279468 54494
Contact:
Site Public Contact
715-422-7718
Site Public Contact
715-422-7718
More Details
- NCT ID
- NCT05624996
- Status
- Recruiting
- Sponsor
- NRG Oncology
Detailed Description
PRIMARY OBJECTIVES: I. To compare the overall survival in patients with stage II-IIIC inoperable node-positive non-small cell lung cancer (NSCLC) after image guided, motion-managed conventional radiotherapy to the primary tumor and nodal metastases (Arm 1) or after image guided, motion-managed stereotactic body radiation therapy (SBRT) to the primary tumor followed by conventionally fractionated radiotherapy to nodal metastases (Arm 2) both given with concurrent platinum-based chemotherapy. II. To compare progression-free survival between the experimental arm (Arm 2) and control arm (Arm 1). SECONDARY OBJECTIVES: I. To compare objective response rate (as defined by Response Evaluation Criteria in Solid Tumors [RECIST] version [v] 1.1) between the experimental arm and control arm. II. To compare the rate of local control between the experimental arm and control arm. III. To compare patterns of failure (primary, locoregional, or distant) between the experimental arm and control arm. IV. To compare changes in pulmonary function (forced expiratory volume in 1 second [FEV1] and diffusion capacity of the lung for carbon monoxide [DLCO] assessed at randomization and at 6- and 12- months following completion of radiation therapy) between the experimental arm and control arm. V. To compare changes in quality of life and patient-reported outcomes assessed from pre-treatment to 3 months following radiation therapy of each treatment arm. VI. To determine acute and late toxicity profiles of each treatment arm as measured by the Common Terminology Criteria for Adverse Events (CTCAE) v5. EXPLORATORY OBJECTIVES: I. To characterize and compare longitudinal quality of life and patient-reported outcomes of each treatment arm. II. To collect biospecimens at baseline, after SBRT (for Arm 2 patients), during last 2 weeks of chemoradiation, and after first dose of consolidation therapy, to allow for future analyses. III. To collect 4-dimensional (4D) computed tomography (CT) planning scans and radiation dose to calculate regional lung ventilation and explore pre-treatment 4D-CT based ventilation to predict pulmonary toxicity. IV. To characterize clinical outcomes, toxicities and changes in pulmonary function and quality of life among patients receiving proton and photon radiotherapy. V. To develop and characterize a machine learning/artificial intelligence algorithm for radiotherapy planning and/or quality assurance. OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients undergo conventional IGRT and receive usual care chemotherapy consisting of paclitaxel intravenously (IV) followed by carboplatin IV weekly (Q7D) during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or positron emission tomography (PET)/CT during follow-up. ARM II: Patients undergo SBRT and conventional IGRT and receive standard-of-care chemotherapy consisting of paclitaxel IV followed by carboplatin IV Q7D during radiotherapy or pemetrexed IV followed by carboplatin IV every 21 days during radiotherapy or etoposide IV on days 1 to 5 and days 29 to 33 followed by cisplatin IV on days 1, 8, 29, and 36 or pemetrexed IV followed by cisplatin IV every 21 days during radiotherapy. Patients then receive consolidation durvalumab IV every 2 or 4 weeks for up to one year in the absence of disease progression or unacceptable toxicity. Patients also undergo CT and/or PET/CT during follow-up. Patients are followed up every 3 months for 1 year, every 6 months during years 2 and 3, and then yearly after that for the duration of the study.